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Protein

Integral membrane protein GPR137B

Gene

GPR137B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000077585-MONOMER.

Protein family/group databases

TCDBi9.B.123.1.1. the lysosomal 7-tms (tm7sf1) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Integral membrane protein GPR137B
Alternative name(s):
Transmembrane 7 superfamily member 1 protein
Gene namesi
Name:GPR137B
Synonyms:TM7SF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:11862. GPR137B.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 46ExtracellularSequence analysisAdd BLAST46
Transmembranei47 – 67HelicalSequence analysisAdd BLAST21
Topological domaini68 – 79CytoplasmicSequence analysisAdd BLAST12
Transmembranei80 – 100HelicalSequence analysisAdd BLAST21
Topological domaini101 – 111ExtracellularSequence analysisAdd BLAST11
Transmembranei112 – 132HelicalSequence analysisAdd BLAST21
Topological domaini133 – 159CytoplasmicSequence analysisAdd BLAST27
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Topological domaini181 – 188ExtracellularSequence analysis8
Transmembranei189 – 209HelicalSequence analysisAdd BLAST21
Topological domaini210 – 237CytoplasmicSequence analysisAdd BLAST28
Transmembranei238 – 258HelicalSequence analysisAdd BLAST21
Topological domaini259 – 292ExtracellularSequence analysisAdd BLAST34
Transmembranei293 – 313HelicalSequence analysisAdd BLAST21
Topological domaini314 – 399CytoplasmicSequence analysisAdd BLAST86

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • lysosomal membrane Source: UniProtKB-SubCell
  • membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000077585.
PharmGKBiPA36563.

Polymorphism and mutation databases

BioMutaiGPR137B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000725831 – 399Integral membrane protein GPR137BAdd BLAST399

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi26N-linked (GlcNAc...)Sequence analysis1
Glycosylationi263N-linked (GlcNAc...)Sequence analysis1
Glycosylationi275N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO60478.
PeptideAtlasiO60478.
PRIDEiO60478.

PTM databases

iPTMnetiO60478.
PhosphoSitePlusiO60478.

Expressioni

Tissue specificityi

Expressed in kidney, heart, brain and placenta.1 Publication

Gene expression databases

BgeeiENSG00000077585.
CleanExiHS_GPR137B.
ExpressionAtlasiO60478. baseline and differential.
GenevisibleiO60478. HS.

Organism-specific databases

HPAiHPA026422.

Interactioni

Protein-protein interaction databases

BioGridi112962. 6 interactors.
STRINGi9606.ENSP00000355551.

Structurei

3D structure databases

ProteinModelPortaliO60478.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPR137 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGBD. Eukaryota.
ENOG410XQNA. LUCA.
GeneTreeiENSGT00390000008320.
HOGENOMiHOG000286020.
HOVERGENiHBG058911.
InParanoidiO60478.
OMAiYKIAKMS.
OrthoDBiEOG091G08XG.
PhylomeDBiO60478.
TreeFamiTF329003.

Family and domain databases

InterProiIPR029723. GPR137.
[Graphical view]
PANTHERiPTHR15146. PTHR15146. 1 hit.

Sequencei

Sequence statusi: Complete.

O60478-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPERPRPRG SAPGPMETPP WDPARNDSLP PTLTPAVPPY VKLGLTVVYT
60 70 80 90 100
VFYALLFVFI YVQLWLVLRY RHKRLSYQSV FLFLCLFWAS LRTVLFSFYF
110 120 130 140 150
KDFVAANSLS PFVFWLLYCF PVCLQFFTLT LMNLYFTQVI FKAKSKYSPE
160 170 180 190 200
LLKYRLPLYL ASLFISLVFL LVNLTCAVLV KTGNWERKVI VSVRVAINDT
210 220 230 240 250
LFVLCAVSLS ICLYKISKMS LANIYLESKG SSVCQVTAIG VTVILLYTSR
260 270 280 290 300
ACYNLFILSF SQNKSVHSFD YDWYNVSDQA DLKNQLGDAG YVLFGVVLFV
310 320 330 340 350
WELLPTTLVV YFFRVRNPTK DLTNPGMVPS HGFSPRSYFF DNPRRYDSDD
360 370 380 390
DLAWNIAPQG LQGGFAPDYY DWGQQTNSFL AQAGTLQDST LDPDKPSLG
Length:399
Mass (Da):45,599
Last modified:August 1, 1998 - v1
Checksum:iFE788D618A590604
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7R → G in CAG46569 (Ref. 3) Curated1
Sequence conflicti54A → S in CAG46569 (Ref. 3) Curated1
Sequence conflicti178V → M in BAD97352 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF027826 mRNA. Translation: AAC39669.1.
AY242135 mRNA. Translation: AAO92302.1.
CR541770 mRNA. Translation: CAG46569.1.
AK223632 mRNA. Translation: BAD97352.1.
AL122018, AL139162 Genomic DNA. Translation: CAI22684.1.
AL139162, AL122018 Genomic DNA. Translation: CAI23528.1.
CH471098 Genomic DNA. Translation: EAW70043.1.
BC012100 mRNA. Translation: AAH12100.1.
CCDSiCCDS1609.1.
RefSeqiNP_003263.1. NM_003272.3.
UniGeneiHs.498160.

Genome annotation databases

EnsembliENST00000366592; ENSP00000355551; ENSG00000077585.
GeneIDi7107.
KEGGihsa:7107.
UCSCiuc001hxq.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF027826 mRNA. Translation: AAC39669.1.
AY242135 mRNA. Translation: AAO92302.1.
CR541770 mRNA. Translation: CAG46569.1.
AK223632 mRNA. Translation: BAD97352.1.
AL122018, AL139162 Genomic DNA. Translation: CAI22684.1.
AL139162, AL122018 Genomic DNA. Translation: CAI23528.1.
CH471098 Genomic DNA. Translation: EAW70043.1.
BC012100 mRNA. Translation: AAH12100.1.
CCDSiCCDS1609.1.
RefSeqiNP_003263.1. NM_003272.3.
UniGeneiHs.498160.

3D structure databases

ProteinModelPortaliO60478.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112962. 6 interactors.
STRINGi9606.ENSP00000355551.

Protein family/group databases

TCDBi9.B.123.1.1. the lysosomal 7-tms (tm7sf1) family.

PTM databases

iPTMnetiO60478.
PhosphoSitePlusiO60478.

Polymorphism and mutation databases

BioMutaiGPR137B.

Proteomic databases

PaxDbiO60478.
PeptideAtlasiO60478.
PRIDEiO60478.

Protocols and materials databases

DNASUi7107.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366592; ENSP00000355551; ENSG00000077585.
GeneIDi7107.
KEGGihsa:7107.
UCSCiuc001hxq.3. human.

Organism-specific databases

CTDi7107.
GeneCardsiGPR137B.
HGNCiHGNC:11862. GPR137B.
HPAiHPA026422.
MIMi604658. gene.
neXtProtiNX_O60478.
OpenTargetsiENSG00000077585.
PharmGKBiPA36563.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGBD. Eukaryota.
ENOG410XQNA. LUCA.
GeneTreeiENSGT00390000008320.
HOGENOMiHOG000286020.
HOVERGENiHBG058911.
InParanoidiO60478.
OMAiYKIAKMS.
OrthoDBiEOG091G08XG.
PhylomeDBiO60478.
TreeFamiTF329003.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000077585-MONOMER.

Miscellaneous databases

ChiTaRSiGPR137B. human.
GenomeRNAii7107.
PROiO60478.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000077585.
CleanExiHS_GPR137B.
ExpressionAtlasiO60478. baseline and differential.
GenevisibleiO60478. HS.

Family and domain databases

InterProiIPR029723. GPR137.
[Graphical view]
PANTHERiPTHR15146. PTHR15146. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiG137B_HUMAN
AccessioniPrimary (citable) accession number: O60478
Secondary accession number(s): Q53EK7, Q5TAE6, Q6FHI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: August 1, 1998
Last modified: November 2, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.