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Protein

BMP/retinoic acid-inducible neural-specific protein 1

Gene

BRINP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits cell proliferation by negative regulation of the G1/S transition. Mediates cell death which is not of the classical apoptotic type and regulates expression of components of the plasminogen pathway.3 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Growth arrest

Names & Taxonomyi

Protein namesi
Recommended name:
BMP/retinoic acid-inducible neural-specific protein 1
Alternative name(s):
Deleted in bladder cancer protein 1
Gene namesi
Name:BRINP1
Synonyms:DBC1, DBCCR1, FAM5A
ORF Names:IB3089A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:2687. BRINP1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27156.

Polymorphism and mutation databases

BioMutaiDBC1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 761742BMP/retinoic acid-inducible neural-specific protein 1PRO_0000045766Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi156 – 1561N-linked (GlcNAc...)Sequence analysis
Glycosylationi433 – 4331N-linked (GlcNAc...)Sequence analysis
Glycosylationi443 – 4431N-linked (GlcNAc...)Sequence analysis
Glycosylationi553 – 5531N-linked (GlcNAc...)Sequence analysis
Glycosylationi599 – 5991N-linked (GlcNAc...)Sequence analysis
Glycosylationi631 – 6311N-linked (GlcNAc...)Sequence analysis
Glycosylationi677 – 6771N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO60477.
PRIDEiO60477.

PTM databases

iPTMnetiO60477.
PhosphoSiteiO60477.

Expressioni

Tissue specificityi

Highly expressed in brain. Weakly expressed in heart, lung, skeletal muscle, kidney, thymus, prostate, testis and small intestine.1 Publication

Gene expression databases

BgeeiO60477.
CleanExiHS_DBC1.
GenevisibleiO60477. HS.

Organism-specific databases

HPAiHPA038828.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ZNF326Q5BKZ15EBI-3904864,EBI-2560158

Protein-protein interaction databases

BioGridi107988. 29 interactions.
IntActiO60477. 22 interactions.
STRINGi9606.ENSP00000265922.

Structurei

3D structure databases

ProteinModelPortaliO60477.
SMRiO60477. Positions 92-153.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini68 – 251184MACPFAdd
BLAST

Sequence similaritiesi

Belongs to the BRINP family.Curated
Contains 1 MACPF domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IF4X. Eukaryota.
ENOG410XQ74. LUCA.
GeneTreeiENSGT00390000008571.
HOGENOMiHOG000049122.
HOVERGENiHBG081412.
InParanoidiO60477.
OMAiPNHQMPR.
OrthoDBiEOG764720.
PhylomeDBiO60477.
TreeFamiTF331600.

Family and domain databases

InterProiIPR033237. BRINP.
IPR020864. MACPF.
[Graphical view]
PANTHERiPTHR15564. PTHR15564. 1 hit.
PfamiPF01823. MACPF. 1 hit.
[Graphical view]
SMARTiSM00457. MACPF. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O60477-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNWRFVELLY FLFIWGRISV QPSHQEPAGT DQHVSKEFDW LISDRGPFHH
60 70 80 90 100
SRSYLSFVER HRQGFTTRYK IYREFARWKV RNTAIERRDL VRHPVPLMPE
110 120 130 140 150
FQRSIRLLGR RPTTQQFIDT IIKKYGTHLL ISATLGGEEA LTMYMDKSRL
160 170 180 190 200
DRKSGNATQS VEALHQLASS YFVDRDGTMR RLHEIQISTG AIKVTETRTG
210 220 230 240 250
PLGCNSYDNL DSVSSVLLQS TESKLHLQGL QIIFPQYLQE KFVQSALSYI
260 270 280 290 300
MCNGEGEYLC QNSQCRCQCA EEFPQCNCPI TDIQIMEYTL ANMAKSWAEA
310 320 330 340 350
YKDLENSDEF KSFMKRLPSN HFLTIGSIHQ HWGNDWDLQN RYKLLQSATE
360 370 380 390 400
AQRQKIQRTA RKLFGLSVRC RHNPNHQLPR ERTIQQWLAR VQSLLYCNEN
410 420 430 440 450
GFWGTFLESQ RSCVCHGSTT LCQRPIPCVI GGNNSCAMCS LANISLCGSC
460 470 480 490 500
NKGYKLYRGR CEPQNVDSER SEQFISFETD LDFQDLELKY LLQKMDSRLY
510 520 530 540 550
VHTTFISNEI RLDTFFDPRW RKRMSLTLKS NKNRMDFIHM VIGMSMRICQ
560 570 580 590 600
MRNSSLDPMF FVYVNPFSGS HSEGWNMPFG EFGYPRWEKI RLQNSQCYNW
610 620 630 640 650
TLLLGNRWKT FFETVHIYLR SRTRLPTLLR NETGQGPVDL SDPSKRQFYI
660 670 680 690 700
KISDVQVFGY SLRFNADLLR SAVQQVNQSY TQGGQFYSSS SVMLLLLDIR
710 720 730 740 750
DRINRLAPPV APGKPQLDLF SCMLKHRLKL TNSEIIRVNH ALDLYNTEIL
760
KQSDQMTAKL C
Length:761
Mass (Da):88,760
Last modified:January 24, 2006 - v2
Checksum:i16FF47082FD52252
GO
Isoform 2 (identifier: O60477-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     308-320: DEFKSFMKRLPSN → GRESHSVPLHEWP
     321-761: Missing.

Note: No experimental confirmation available.
Show »
Length:320
Mass (Da):37,168
Checksum:i216A4CB3D764C5C3
GO
Isoform 3 (identifier: O60477-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-285: Missing.

Note: No experimental confirmation available.
Show »
Length:476
Mass (Da):55,671
Checksum:iC27A7EF8373CAA04
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti347 – 3471S → R Common polymorphism. 1 Publication
VAR_029989
Natural varianti358 – 3581R → H Common polymorphism. 1 Publication
Corresponds to variant rs17476783 [ dbSNP | Ensembl ].
VAR_029990
Natural varianti437 – 4371A → T.2 Publications
Corresponds to variant rs1043377 [ dbSNP | Ensembl ].
VAR_024930
Natural varianti712 – 7121P → T in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036336

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 285285Missing in isoform 3. 1 PublicationVSP_017021Add
BLAST
Alternative sequencei308 – 32013DEFKS…RLPSN → GRESHSVPLHEWP in isoform 2. 1 PublicationVSP_017022Add
BLAST
Alternative sequencei321 – 761441Missing in isoform 2. 1 PublicationVSP_017023Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF027734 mRNA. Translation: AAC39691.1.
AL138894, AL353773 Genomic DNA. Translation: CAH72027.1.
AL138894, AL353773 Genomic DNA. Translation: CAH72028.1.
AL353773, AL138894 Genomic DNA. Translation: CAI16000.1.
AL353773, AL138894 Genomic DNA. Translation: CAI16001.1.
BC021560 mRNA. Translation: AAH21560.1.
BC065196 mRNA. Translation: AAH65196.1.
BC071702 mRNA. Translation: AAH71702.1.
CCDSiCCDS6822.1. [O60477-1]
PIRiT09052.
RefSeqiNP_055433.2. NM_014618.2. [O60477-1]
UniGeneiHs.532316.

Genome annotation databases

EnsembliENST00000265922; ENSP00000265922; ENSG00000078725. [O60477-1]
ENST00000373964; ENSP00000363075; ENSG00000078725. [O60477-2]
GeneIDi1620.
KEGGihsa:1620.
UCSCiuc004bkc.3. human. [O60477-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF027734 mRNA. Translation: AAC39691.1.
AL138894, AL353773 Genomic DNA. Translation: CAH72027.1.
AL138894, AL353773 Genomic DNA. Translation: CAH72028.1.
AL353773, AL138894 Genomic DNA. Translation: CAI16000.1.
AL353773, AL138894 Genomic DNA. Translation: CAI16001.1.
BC021560 mRNA. Translation: AAH21560.1.
BC065196 mRNA. Translation: AAH65196.1.
BC071702 mRNA. Translation: AAH71702.1.
CCDSiCCDS6822.1. [O60477-1]
PIRiT09052.
RefSeqiNP_055433.2. NM_014618.2. [O60477-1]
UniGeneiHs.532316.

3D structure databases

ProteinModelPortaliO60477.
SMRiO60477. Positions 92-153.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107988. 29 interactions.
IntActiO60477. 22 interactions.
STRINGi9606.ENSP00000265922.

PTM databases

iPTMnetiO60477.
PhosphoSiteiO60477.

Polymorphism and mutation databases

BioMutaiDBC1.

Proteomic databases

PaxDbiO60477.
PRIDEiO60477.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265922; ENSP00000265922; ENSG00000078725. [O60477-1]
ENST00000373964; ENSP00000363075; ENSG00000078725. [O60477-2]
GeneIDi1620.
KEGGihsa:1620.
UCSCiuc004bkc.3. human. [O60477-1]

Organism-specific databases

CTDi1620.
GeneCardsiBRINP1.
H-InvDBHIX0034750.
HGNCiHGNC:2687. BRINP1.
HPAiHPA038828.
MIMi602865. gene.
neXtProtiNX_O60477.
PharmGKBiPA27156.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF4X. Eukaryota.
ENOG410XQ74. LUCA.
GeneTreeiENSGT00390000008571.
HOGENOMiHOG000049122.
HOVERGENiHBG081412.
InParanoidiO60477.
OMAiPNHQMPR.
OrthoDBiEOG764720.
PhylomeDBiO60477.
TreeFamiTF331600.

Miscellaneous databases

GeneWikiiDBC1.
GenomeRNAii1620.
NextBioi6650.
PROiO60477.
SOURCEiSearch...

Gene expression databases

BgeeiO60477.
CleanExiHS_DBC1.
GenevisibleiO60477. HS.

Family and domain databases

InterProiIPR033237. BRINP.
IPR020864. MACPF.
[Graphical view]
PANTHERiPTHR15564. PTHR15564. 1 hit.
PfamiPF01823. MACPF. 1 hit.
[Graphical view]
SMARTiSM00457. MACPF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and methylation-based silencing of a gene (DBCCR1) within a candidate bladder cancer tumor suppressor region at 9q32-q33."
    Habuchi T., Luscombe M., Elder P.A., Knowles M.A.
    Genomics 48:277-288(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT THR-437, TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Brain and Kidney.
  4. "Negative regulation of G(1)/S transition by the candidate bladder tumour suppressor gene DBCCR1."
    Nishiyama H., Gill J.H., Pitt E., Kennedy W., Knowles M.A.
    Oncogene 20:2956-2964(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, VARIANTS ARG-347; HIS-358 AND THR-437.
  5. "DBCCR1 mediates death in cultured bladder tumor cells."
    Wright K.O., Messing E.M., Reeder J.E.
    Oncogene 23:82-90(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "DBC1 re-expression alters the expression of multiple components of the plasminogen pathway."
    Louhelainen J.P., Hurst C.D., Pitt E., Nishiyama H., Pickett H.A., Knowles M.A.
    Oncogene 25:2409-2419(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-712.

Entry informationi

Entry nameiBRNP1_HUMAN
AccessioniPrimary (citable) accession number: O60477
Secondary accession number(s): Q6IPV6, Q6P1A0, Q8WU22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: January 24, 2006
Last modified: May 11, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Silenced by methylation in 50% of bladder cancer cell lines.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.