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Protein

BMP/retinoic acid-inducible neural-specific protein 1

Gene

BRINP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits cell proliferation by negative regulation of the G1/S transition. Mediates cell death which is not of the classical apoptotic type and regulates expression of components of the plasminogen pathway.3 Publications

Miscellaneous

Silenced by methylation in 50% of bladder cancer cell lines.

GO - Biological processi

Keywordsi

Biological processCell cycle, Growth arrest

Protein family/group databases

TCDBi1.C.39.17.1 the membrane attack complex/perforin (macpf) family

Names & Taxonomyi

Protein namesi
Recommended name:
BMP/retinoic acid-inducible neural-specific protein 1
Alternative name(s):
Deleted in bladder cancer protein 1
Gene namesi
Name:BRINP1
Synonyms:DBC1, DBCCR1, FAM5A
ORF Names:IB3089A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000078725.12
HGNCiHGNC:2687 BRINP1
MIMi602865 gene
neXtProtiNX_O60477

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi1620
OpenTargetsiENSG00000078725
PharmGKBiPA27156

Polymorphism and mutation databases

BioMutaiDBC1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000004576620 – 761BMP/retinoic acid-inducible neural-specific protein 1Add BLAST742

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi156N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi433N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi443N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi553N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi599N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi631N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi677N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO60477
PeptideAtlasiO60477
PRIDEiO60477
ProteomicsDBi49417
49418 [O60477-2]
49419 [O60477-3]

PTM databases

iPTMnetiO60477
PhosphoSitePlusiO60477

Expressioni

Tissue specificityi

Highly expressed in brain. Weakly expressed in heart, lung, skeletal muscle, kidney, thymus, prostate, testis and small intestine.1 Publication

Gene expression databases

BgeeiENSG00000078725
CleanExiHS_DBC1
GenevisibleiO60477 HS

Organism-specific databases

HPAiHPA038828

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ZNF326Q5BKZ15EBI-3904864,EBI-2560158

Protein-protein interaction databases

BioGridi107988, 31 interactors
IntActiO60477, 22 interactors
STRINGi9606.ENSP00000265922

Structurei

3D structure databases

ProteinModelPortaliO60477
SMRiO60477
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini68 – 251MACPFAdd BLAST184

Sequence similaritiesi

Belongs to the BRINP family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IF4X Eukaryota
ENOG410XQ74 LUCA
GeneTreeiENSGT00390000008571
HOGENOMiHOG000049122
HOVERGENiHBG081412
InParanoidiO60477
OMAiPNHQMPR
OrthoDBiEOG091G02AS
PhylomeDBiO60477
TreeFamiTF331600

Family and domain databases

InterProiView protein in InterPro
IPR033237 BRINP
IPR020864 MACPF
PANTHERiPTHR15564 PTHR15564, 1 hit
PfamiView protein in Pfam
PF01823 MACPF, 1 hit
SMARTiView protein in SMART
SM00457 MACPF, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O60477-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNWRFVELLY FLFIWGRISV QPSHQEPAGT DQHVSKEFDW LISDRGPFHH
60 70 80 90 100
SRSYLSFVER HRQGFTTRYK IYREFARWKV RNTAIERRDL VRHPVPLMPE
110 120 130 140 150
FQRSIRLLGR RPTTQQFIDT IIKKYGTHLL ISATLGGEEA LTMYMDKSRL
160 170 180 190 200
DRKSGNATQS VEALHQLASS YFVDRDGTMR RLHEIQISTG AIKVTETRTG
210 220 230 240 250
PLGCNSYDNL DSVSSVLLQS TESKLHLQGL QIIFPQYLQE KFVQSALSYI
260 270 280 290 300
MCNGEGEYLC QNSQCRCQCA EEFPQCNCPI TDIQIMEYTL ANMAKSWAEA
310 320 330 340 350
YKDLENSDEF KSFMKRLPSN HFLTIGSIHQ HWGNDWDLQN RYKLLQSATE
360 370 380 390 400
AQRQKIQRTA RKLFGLSVRC RHNPNHQLPR ERTIQQWLAR VQSLLYCNEN
410 420 430 440 450
GFWGTFLESQ RSCVCHGSTT LCQRPIPCVI GGNNSCAMCS LANISLCGSC
460 470 480 490 500
NKGYKLYRGR CEPQNVDSER SEQFISFETD LDFQDLELKY LLQKMDSRLY
510 520 530 540 550
VHTTFISNEI RLDTFFDPRW RKRMSLTLKS NKNRMDFIHM VIGMSMRICQ
560 570 580 590 600
MRNSSLDPMF FVYVNPFSGS HSEGWNMPFG EFGYPRWEKI RLQNSQCYNW
610 620 630 640 650
TLLLGNRWKT FFETVHIYLR SRTRLPTLLR NETGQGPVDL SDPSKRQFYI
660 670 680 690 700
KISDVQVFGY SLRFNADLLR SAVQQVNQSY TQGGQFYSSS SVMLLLLDIR
710 720 730 740 750
DRINRLAPPV APGKPQLDLF SCMLKHRLKL TNSEIIRVNH ALDLYNTEIL
760
KQSDQMTAKL C
Length:761
Mass (Da):88,760
Last modified:January 24, 2006 - v2
Checksum:i16FF47082FD52252
GO
Isoform 2 (identifier: O60477-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     308-320: DEFKSFMKRLPSN → GRESHSVPLHEWP
     321-761: Missing.

Note: No experimental confirmation available.
Show »
Length:320
Mass (Da):37,168
Checksum:i216A4CB3D764C5C3
GO
Isoform 3 (identifier: O60477-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-285: Missing.

Note: No experimental confirmation available.
Show »
Length:476
Mass (Da):55,671
Checksum:iC27A7EF8373CAA04
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_029989347S → R Common polymorphism. 1 Publication1
Natural variantiVAR_029990358R → H Common polymorphism. 1 PublicationCorresponds to variant dbSNP:rs17476783Ensembl.1
Natural variantiVAR_024930437A → T2 PublicationsCorresponds to variant dbSNP:rs1043377Ensembl.1
Natural variantiVAR_036336712P → T in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0170211 – 285Missing in isoform 3. 1 PublicationAdd BLAST285
Alternative sequenceiVSP_017022308 – 320DEFKS…RLPSN → GRESHSVPLHEWP in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_017023321 – 761Missing in isoform 2. 1 PublicationAdd BLAST441

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF027734 mRNA Translation: AAC39691.1
AL138894 Genomic DNA No translation available.
AL353773 Genomic DNA No translation available.
BC021560 mRNA Translation: AAH21560.1
BC065196 mRNA Translation: AAH65196.1
BC071702 mRNA Translation: AAH71702.1
CCDSiCCDS6822.1 [O60477-1]
PIRiT09052
RefSeqiNP_055433.2, NM_014618.2 [O60477-1]
UniGeneiHs.532316

Genome annotation databases

EnsembliENST00000265922; ENSP00000265922; ENSG00000078725 [O60477-1]
ENST00000373964; ENSP00000363075; ENSG00000078725 [O60477-2]
GeneIDi1620
KEGGihsa:1620
UCSCiuc004bkc.3 human [O60477-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiBRNP1_HUMAN
AccessioniPrimary (citable) accession number: O60477
Secondary accession number(s): Q6IPV6, Q6P1A0, Q8WU22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: January 24, 2006
Last modified: June 20, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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