O60462 (NRP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neuropilin-2

Alternative name(s):
Vascular endothelial cell growth factor 165 receptor 2

Gene names

Name:	NRP2
Synonyms:	VEGF165R2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	931 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.
Subunit structure	Heterodimer with NRP1. Binds PLXNB1. Ref.9
Subcellular location	Membrane; Single-pass type I membrane protein Ref.3. Isoform s9: Secreted Ref.3.
Domain	The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin and VEGF binding.
Sequence similarities	Belongs to the neuropilin family. Contains 2 CUB domains. Contains 2 F5/8 type C domains. Contains 1 MAM domain.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis
Cellular component	Membrane Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Signal Transmembrane Transmembrane helix
Ligand	Calcium Heparin-binding Metal-binding
Molecular function	Developmental protein Receptor
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	angiogenesis Non-traceable author statement Ref.3. Source: UniProtKB axon guidance Non-traceable author statement PubMed 19909241. Source: BHF-UCL cell adhesion Non-traceable author statement Ref.3. Source: UniProtKB heart development Inferred from electronic annotation. Source: Compara negative chemotaxis Inferred from electronic annotation. Source: Compara neural crest cell migration Inferred from electronic annotation. Source: Compara positive regulation of endothelial cell migration Traceable author statement PubMed 21245381. Source: BHF-UCL positive regulation of endothelial cell proliferation Traceable author statement PubMed 21245381. Source: BHF-UCL vascular endothelial growth factor receptor signaling pathway Traceable author statement. Source: Reactome
Cellular_component	axon Inferred from electronic annotation. Source: Compara extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Non-traceable author statement Ref.3. Source: UniProtKB plasma membrane Traceable author statement. Source: Reactome semaphorin receptor complex Non-traceable author statement PubMed 19909241. Source: BHF-UCL
Molecular_function	cytokine binding Non-traceable author statement PubMed 19909241. Source: BHF-UCL growth factor binding Traceable author statement PubMed 21245381. Source: BHF-UCL heparin binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW semaphorin receptor activity Non-traceable author statement Ref.3. Source: UniProtKB vascular endothelial growth factor-activated receptor activity Non-traceable author statement Ref.3. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform A22 (identifier: O60462-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform A0 (identifier: O60462-2)

The sequence of this isoform differs from the canonical sequence as follows:
     809-830: Missing.

Isoform A17 (identifier: O60462-3)

The sequence of this isoform differs from the canonical sequence as follows:
     809-813: Missing.

Isoform B0 (identifier: O60462-4)

The sequence of this isoform differs from the canonical sequence as follows:
     809-813: Missing.
     814-931: VDIPEIHERE...MNHQKCCSEA → GGTLLPGTEP...KLEQDRGSHC

Isoform B5 (identifier: O60462-5)

The sequence of this isoform differs from the canonical sequence as follows:
     814-931: VDIPEIHERE...MNHQKCCSEA → GGTLLPGTEP...KLEQDRGSHC

Isoform s9 (identifier: O60462-6)

The sequence of this isoform differs from the canonical sequence as follows:
     548-555: LFEGNMHY → VGCSWRPL
     556-931: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 20

20

Or 22 Potential

Chain

21 – 931

911

Neuropilin-2

PRO_0000021863

Regions

Topological domain

21 – 864

844

Extracellular Potential

Transmembrane

865 – 889

25

Helical; Potential

Topological domain

890 – 931

42

Cytoplasmic Potential

Domain

28 – 142

115

CUB 1

Domain

149 – 267

119

CUB 2

Domain

277 – 427

151

F5/8 type C 1

Domain

434 – 592

159

F5/8 type C 2

Domain

642 – 802

161

MAM

Compositional bias

671 – 674

4

Poly-Ser

Sites

Metal binding

197

1

Calcium

Metal binding

211

1

Calcium

Metal binding

252

1

Calcium

Amino acid modifications

Glycosylation

152

1

N-linked (GlcNAc...)

Glycosylation

157

1

N-linked (GlcNAc...)

Glycosylation

629

1

N-linked (GlcNAc...) Potential

Glycosylation

839

1

N-linked (GlcNAc...) Potential

Disulfide bond

28 ↔ 55

Ref.9

Disulfide bond

83 ↔ 105

Ref.9

Disulfide bond

149 ↔ 175

Ref.9

Disulfide bond

208 ↔ 230

Ref.9

Disulfide bond

277 ↔ 427

Ref.9

Disulfide bond

434 ↔ 592

Ref.9

Natural variations

Alternative sequence

548 – 555

8

LFEGNMHY → VGCSWRPL in isoform s9.

VSP_044908

Alternative sequence

556 – 931

376

Missing in isoform s9.

VSP_044909

Alternative sequence

809 – 830

22

Missing in isoform A0.

VSP_004342

Alternative sequence

809 – 813

5

Missing in isoform A17 and isoform B0.

VSP_004341

Alternative sequence

814 – 931

118

VDIPE…CCSEA → GGTLLPGTEPTVDTVPMQPI PAYWYYVMAAGGAVLVLVSV ALALVLHYHRFRYAAKKTDH SITYKTSHYTNGAPLAVEPT LTIKLEQDRGSHC in isoform B0 and isoform B5.

VSP_041160

Natural variant

123

1

R → K. Ref.1 Ref.2 Ref.3 Ref.5 Ref.6
Corresponds to variant rs849541 [ dbSNP | Ensembl ].

VAR_047754

Natural variant

334

1

R → C Rare variant; may act as a phenotype modifier in EIEE13 patients carrying SCN8A mutations. Ref.10
Corresponds to variant rs114144673 [ dbSNP | Ensembl ].

VAR_067537

Natural variant

428

1

R → W Rare variant; may act as a phenotype modifier in EIEE13 patients carrying SCN8A mutations. Ref.10
Corresponds to variant rs139711818 [ dbSNP | Ensembl ].

VAR_067538

Natural variant

602

1

E → K. Ref.1 Ref.3
Corresponds to variant rs1128169 [ dbSNP | Ensembl ].

VAR_065167

Secondary structure

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931

Helix Strand Turn

Details...

Beta strand

30 – 33

4

Beta strand

38 – 41

4

Turn

43 – 46

4

Beta strand

55 – 60

6

Beta strand

66 – 72

7

Beta strand

83 – 95

13

Beta strand

98 – 104

7

Beta strand

116 – 125

10

Beta strand

136 – 142

7

Beta strand

151 – 153

3

Beta strand

155 – 161

7

Turn

163 – 166

4

Beta strand

174 – 180

7

Beta strand

186 – 195

10

Beta strand

210 – 219

10

Turn

220 – 222

3

Beta strand

225 – 229

5

Beta strand

231 – 233

3

Beta strand

238 – 240

3

Beta strand

242 – 250

9

Beta strand

255 – 257

3

Beta strand

259 – 267

9

Turn

283 – 285

3

Beta strand

286 – 288

3

Helix

290 – 292

3

Beta strand

293 – 296

4

Beta strand

302 – 304

3

Helix

306 – 308

3

Beta strand

324 – 326

3

Beta strand

329 – 345

17

Turn

350 – 352

3

Beta strand

355 – 371

17

Beta strand

376 – 381

6

Beta strand

388 – 391

4

Beta strand

394 – 417

24

Beta strand

420 – 427

8

Helix

429 – 431

3

Beta strand

432 – 434

3

Turn

440 – 442

3

Beta strand

443 – 445

3

Helix

447 – 449

3

Beta strand

450 – 453

4

Beta strand

457 – 459

3

Helix

462 – 465

4

Turn

467 – 469

3

Beta strand

470 – 472

3

Beta strand

477 – 480

4

Turn

483 – 485

3

Beta strand

488 – 504

17

Helix

515 – 517

3

Beta strand

521 – 534

14

Turn

541 – 544

4

Beta strand

553 – 557

5

Beta strand

559 – 578

20

Beta strand

585 – 593

9

Sequences

	Sequence		Length	Mass (Da)
	Isoform A22 [UniParc]. Last modified November 25, 2008. Version 2. Checksum: EA5CDBB67F3C4B7D	FASTA	931	104,859
	10 20 30 40 50 60 MDMFPLTWVF LALYFSRHQV RGQPDPPCGG RLNSKDAGYI TSPGYPQDYP SHQNCEWIVY 70 80 90 100 110 120 APEPNQKIVL NFNPHFEIEK HDCKYDFIEI RDGDSESADL LGKHCGNIAP PTIISSGSML 130 140 150 160 170 180 YIRFTSDYAR QGAGFSLRYE IFKTGSEDCS KNFTSPNGTI ESPGFPEKYP HNLDCTFTIL 190 200 210 220 230 240 AKPKMEIILQ FLIFDLEHDP LQVGEGDCKY DWLDIWDGIP HVGPLIGKYC GTKTPSELRS 250 260 270 280 290 300 STGILSLTFH TDMAVAKDGF SARYYLVHQE PLENFQCNVP LGMESGRIAN EQISASSTYS 310 320 330 340 350 360 DGRWTPQQSR LHGDDNGWTP NLDSNKEYLQ VDLRFLTMLT AIATQGAISR ETQNGYYVKS 370 380 390 400 410 420 YKLEVSTNGE DWMVYRHGKN HKVFQANNDA TEVVLNKLHA PLLTRFVRIR PQTWHSGIAL 430 440 450 460 470 480 RLELFGCRVT DAPCSNMLGM LSGLIADSQI SASSTQEYLW SPSAARLVSS RSGWFPRIPQ 490 500 510 520 530 540 AQPGEEWLQV DLGTPKTVKG VIIQGARGGD SITAVEARAF VRKFKVSYSL NGKDWEYIQD 550 560 570 580 590 600 PRTQQPKLFE GNMHYDTPDI RRFDPIPAQY VRVYPERWSP AGIGMRLEVL GCDWTDSKPT 610 620 630 640 650 660 VETLGPTVKS EETTTPYPTE EEATECGENC SFEDDKDLQL PSGFNCNFDF LEEPCGWMYD 670 680 690 700 710 720 HAKWLRTTWA SSSSPNDRTF PDDRNFLRLQ SDSQREGQYA RLISPPVHLP RSPVCMEFQY 730 740 750 760 770 780 QATGGRGVAL QVVREASQES KLLWVIREDQ GGEWKHGRII LPSYDMEYQI VFEGVIGKGR 790 800 810 820 830 840 SGEIAIDDIR ISTDVPLENC MEPISAFAGE NFKVDIPEIH EREGYEDEID DEYEVDWSNS 850 860 870 880 890 900 SSATSGSGAP STDKEKSWLY TLDPILITII AMSSLGVLLG ATCAGLLLYC TCSYSGLSSR 910 920 930 SCTTLENYNF ELYDGLKHKV KMNHQKCCSE A
	Isoform A0 [UniParc]. Checksum: 7B0CE20AB8157EE8	FASTA	909	102,243
	10 20 30 40 50 60 MDMFPLTWVF LALYFSRHQV RGQPDPPCGG RLNSKDAGYI TSPGYPQDYP SHQNCEWIVY 70 80 90 100 110 120 APEPNQKIVL NFNPHFEIEK HDCKYDFIEI RDGDSESADL LGKHCGNIAP PTIISSGSML 130 140 150 160 170 180 YIRFTSDYAR QGAGFSLRYE IFKTGSEDCS KNFTSPNGTI ESPGFPEKYP HNLDCTFTIL 190 200 210 220 230 240 AKPKMEIILQ FLIFDLEHDP LQVGEGDCKY DWLDIWDGIP HVGPLIGKYC GTKTPSELRS 250 260 270 280 290 300 STGILSLTFH TDMAVAKDGF SARYYLVHQE PLENFQCNVP LGMESGRIAN EQISASSTYS 310 320 330 340 350 360 DGRWTPQQSR LHGDDNGWTP NLDSNKEYLQ VDLRFLTMLT AIATQGAISR ETQNGYYVKS 370 380 390 400 410 420 YKLEVSTNGE DWMVYRHGKN HKVFQANNDA TEVVLNKLHA PLLTRFVRIR PQTWHSGIAL 430 440 450 460 470 480 RLELFGCRVT DAPCSNMLGM LSGLIADSQI SASSTQEYLW SPSAARLVSS RSGWFPRIPQ 490 500 510 520 530 540 AQPGEEWLQV DLGTPKTVKG VIIQGARGGD SITAVEARAF VRKFKVSYSL NGKDWEYIQD 550 560 570 580 590 600 PRTQQPKLFE GNMHYDTPDI RRFDPIPAQY VRVYPERWSP AGIGMRLEVL GCDWTDSKPT 610 620 630 640 650 660 VETLGPTVKS EETTTPYPTE EEATECGENC SFEDDKDLQL PSGFNCNFDF LEEPCGWMYD 670 680 690 700 710 720 HAKWLRTTWA SSSSPNDRTF PDDRNFLRLQ SDSQREGQYA RLISPPVHLP RSPVCMEFQY 730 740 750 760 770 780 QATGGRGVAL QVVREASQES KLLWVIREDQ GGEWKHGRII LPSYDMEYQI VFEGVIGKGR 790 800 810 820 830 840 SGEIAIDDIR ISTDVPLENC MEPISAFADE YEVDWSNSSS ATSGSGAPST DKEKSWLYTL 850 860 870 880 890 900 DPILITIIAM SSLGVLLGAT CAGLLLYCTC SYSGLSSRSC TTLENYNFEL YDGLKHKVKM NHQKCCSEA
	Isoform A17 [UniParc]. Checksum: A6320C5DFA7785A5	FASTA	926	104,283
	10 20 30 40 50 60 MDMFPLTWVF LALYFSRHQV RGQPDPPCGG RLNSKDAGYI TSPGYPQDYP SHQNCEWIVY 70 80 90 100 110 120 APEPNQKIVL NFNPHFEIEK HDCKYDFIEI RDGDSESADL LGKHCGNIAP PTIISSGSML 130 140 150 160 170 180 YIRFTSDYAR QGAGFSLRYE IFKTGSEDCS KNFTSPNGTI ESPGFPEKYP HNLDCTFTIL 190 200 210 220 230 240 AKPKMEIILQ FLIFDLEHDP LQVGEGDCKY DWLDIWDGIP HVGPLIGKYC GTKTPSELRS 250 260 270 280 290 300 STGILSLTFH TDMAVAKDGF SARYYLVHQE PLENFQCNVP LGMESGRIAN EQISASSTYS 310 320 330 340 350 360 DGRWTPQQSR LHGDDNGWTP NLDSNKEYLQ VDLRFLTMLT AIATQGAISR ETQNGYYVKS 370 380 390 400 410 420 YKLEVSTNGE DWMVYRHGKN HKVFQANNDA TEVVLNKLHA PLLTRFVRIR PQTWHSGIAL 430 440 450 460 470 480 RLELFGCRVT DAPCSNMLGM LSGLIADSQI SASSTQEYLW SPSAARLVSS RSGWFPRIPQ 490 500 510 520 530 540 AQPGEEWLQV DLGTPKTVKG VIIQGARGGD SITAVEARAF VRKFKVSYSL NGKDWEYIQD 550 560 570 580 590 600 PRTQQPKLFE GNMHYDTPDI RRFDPIPAQY VRVYPERWSP AGIGMRLEVL GCDWTDSKPT 610 620 630 640 650 660 VETLGPTVKS EETTTPYPTE EEATECGENC SFEDDKDLQL PSGFNCNFDF LEEPCGWMYD 670 680 690 700 710 720 HAKWLRTTWA SSSSPNDRTF PDDRNFLRLQ SDSQREGQYA RLISPPVHLP RSPVCMEFQY 730 740 750 760 770 780 QATGGRGVAL QVVREASQES KLLWVIREDQ GGEWKHGRII LPSYDMEYQI VFEGVIGKGR 790 800 810 820 830 840 SGEIAIDDIR ISTDVPLENC MEPISAFAVD IPEIHEREGY EDEIDDEYEV DWSNSSSATS 850 860 870 880 890 900 GSGAPSTDKE KSWLYTLDPI LITIIAMSSL GVLLGATCAG LLLYCTCSYS GLSSRSCTTL 910 920 ENYNFELYDG LKHKVKMNHQ KCCSEA
	Isoform B0 [UniParc]. Checksum: D9F51B545CEC6DD8	FASTA	901	101,409
	10 20 30 40 50 60 MDMFPLTWVF LALYFSRHQV RGQPDPPCGG RLNSKDAGYI TSPGYPQDYP SHQNCEWIVY 70 80 90 100 110 120 APEPNQKIVL NFNPHFEIEK HDCKYDFIEI RDGDSESADL LGKHCGNIAP PTIISSGSML 130 140 150 160 170 180 YIRFTSDYAR QGAGFSLRYE IFKTGSEDCS KNFTSPNGTI ESPGFPEKYP HNLDCTFTIL 190 200 210 220 230 240 AKPKMEIILQ FLIFDLEHDP LQVGEGDCKY DWLDIWDGIP HVGPLIGKYC GTKTPSELRS 250 260 270 280 290 300 STGILSLTFH TDMAVAKDGF SARYYLVHQE PLENFQCNVP LGMESGRIAN EQISASSTYS 310 320 330 340 350 360 DGRWTPQQSR LHGDDNGWTP NLDSNKEYLQ VDLRFLTMLT AIATQGAISR ETQNGYYVKS 370 380 390 400 410 420 YKLEVSTNGE DWMVYRHGKN HKVFQANNDA TEVVLNKLHA PLLTRFVRIR PQTWHSGIAL 430 440 450 460 470 480 RLELFGCRVT DAPCSNMLGM LSGLIADSQI SASSTQEYLW SPSAARLVSS RSGWFPRIPQ 490 500 510 520 530 540 AQPGEEWLQV DLGTPKTVKG VIIQGARGGD SITAVEARAF VRKFKVSYSL NGKDWEYIQD 550 560 570 580 590 600 PRTQQPKLFE GNMHYDTPDI RRFDPIPAQY VRVYPERWSP AGIGMRLEVL GCDWTDSKPT 610 620 630 640 650 660 VETLGPTVKS EETTTPYPTE EEATECGENC SFEDDKDLQL PSGFNCNFDF LEEPCGWMYD 670 680 690 700 710 720 HAKWLRTTWA SSSSPNDRTF PDDRNFLRLQ SDSQREGQYA RLISPPVHLP RSPVCMEFQY 730 740 750 760 770 780 QATGGRGVAL QVVREASQES KLLWVIREDQ GGEWKHGRII LPSYDMEYQI VFEGVIGKGR 790 800 810 820 830 840 SGEIAIDDIR ISTDVPLENC MEPISAFAGG TLLPGTEPTV DTVPMQPIPA YWYYVMAAGG 850 860 870 880 890 900 AVLVLVSVAL ALVLHYHRFR YAAKKTDHSI TYKTSHYTNG APLAVEPTLT IKLEQDRGSH C
	Isoform B5 [UniParc]. Checksum: 9C83C9EB47FF74A1	FASTA	906	101,985
	10 20 30 40 50 60 MDMFPLTWVF LALYFSRHQV RGQPDPPCGG RLNSKDAGYI TSPGYPQDYP SHQNCEWIVY 70 80 90 100 110 120 APEPNQKIVL NFNPHFEIEK HDCKYDFIEI RDGDSESADL LGKHCGNIAP PTIISSGSML 130 140 150 160 170 180 YIRFTSDYAR QGAGFSLRYE IFKTGSEDCS KNFTSPNGTI ESPGFPEKYP HNLDCTFTIL 190 200 210 220 230 240 AKPKMEIILQ FLIFDLEHDP LQVGEGDCKY DWLDIWDGIP HVGPLIGKYC GTKTPSELRS 250 260 270 280 290 300 STGILSLTFH TDMAVAKDGF SARYYLVHQE PLENFQCNVP LGMESGRIAN EQISASSTYS 310 320 330 340 350 360 DGRWTPQQSR LHGDDNGWTP NLDSNKEYLQ VDLRFLTMLT AIATQGAISR ETQNGYYVKS 370 380 390 400 410 420 YKLEVSTNGE DWMVYRHGKN HKVFQANNDA TEVVLNKLHA PLLTRFVRIR PQTWHSGIAL 430 440 450 460 470 480 RLELFGCRVT DAPCSNMLGM LSGLIADSQI SASSTQEYLW SPSAARLVSS RSGWFPRIPQ 490 500 510 520 530 540 AQPGEEWLQV DLGTPKTVKG VIIQGARGGD SITAVEARAF VRKFKVSYSL NGKDWEYIQD 550 560 570 580 590 600 PRTQQPKLFE GNMHYDTPDI RRFDPIPAQY VRVYPERWSP AGIGMRLEVL GCDWTDSKPT 610 620 630 640 650 660 VETLGPTVKS EETTTPYPTE EEATECGENC SFEDDKDLQL PSGFNCNFDF LEEPCGWMYD 670 680 690 700 710 720 HAKWLRTTWA SSSSPNDRTF PDDRNFLRLQ SDSQREGQYA RLISPPVHLP RSPVCMEFQY 730 740 750 760 770 780 QATGGRGVAL QVVREASQES KLLWVIREDQ GGEWKHGRII LPSYDMEYQI VFEGVIGKGR 790 800 810 820 830 840 SGEIAIDDIR ISTDVPLENC MEPISAFAGE NFKGGTLLPG TEPTVDTVPM QPIPAYWYYV 850 860 870 880 890 900 MAAGGAVLVL VSVALALVLH YHRFRYAAKK TDHSITYKTS HYTNGAPLAV EPTLTIKLEQ DRGSHC
	Isoform s9 [UniParc]. Checksum: 32CFC8C974D6358E	FASTA	555	62,458
	10 20 30 40 50 60 MDMFPLTWVF LALYFSRHQV RGQPDPPCGG RLNSKDAGYI TSPGYPQDYP SHQNCEWIVY 70 80 90 100 110 120 APEPNQKIVL NFNPHFEIEK HDCKYDFIEI RDGDSESADL LGKHCGNIAP PTIISSGSML 130 140 150 160 170 180 YIRFTSDYAR QGAGFSLRYE IFKTGSEDCS KNFTSPNGTI ESPGFPEKYP HNLDCTFTIL 190 200 210 220 230 240 AKPKMEIILQ FLIFDLEHDP LQVGEGDCKY DWLDIWDGIP HVGPLIGKYC GTKTPSELRS 250 260 270 280 290 300 STGILSLTFH TDMAVAKDGF SARYYLVHQE PLENFQCNVP LGMESGRIAN EQISASSTYS 310 320 330 340 350 360 DGRWTPQQSR LHGDDNGWTP NLDSNKEYLQ VDLRFLTMLT AIATQGAISR ETQNGYYVKS 370 380 390 400 410 420 YKLEVSTNGE DWMVYRHGKN HKVFQANNDA TEVVLNKLHA PLLTRFVRIR PQTWHSGIAL 430 440 450 460 470 480 RLELFGCRVT DAPCSNMLGM LSGLIADSQI SASSTQEYLW SPSAARLVSS RSGWFPRIPQ 490 500 510 520 530 540 AQPGEEWLQV DLGTPKTVKG VIIQGARGGD SITAVEARAF VRKFKVSYSL NGKDWEYIQD 550 PRTQQPKVGC SWRPL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III." Chen H., Chedotal A., He Z.-G., Goodman C.S., Tessier-Lavigne M. Neuron 19:547-559(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A0 AND A17), VARIANTS LYS-123 AND LYS-602.
[2]	"Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor." Soker S., Takashima S., Miao H.-Q., Neufeld G., Klagsbrun M. Cell 92:735-745(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A22), VARIANT LYS-123. Tissue: Mammary gland.
[3]	"Genomic organization of human neuropilin-1 and neuropilin-2 genes: identification and distribution of splice variants and soluble isoforms." Rossignol M., Gagnon M.L., Klagsbrun M. Genomics 70:211-222(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS B0; B5 AND S9), VARIANTS LYS-123 AND LYS-602, ALTERNATIVE SPLICING, SUBCELLULAR LOCATION (ISOFORM S9).
[4]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LYS-123.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS B0 AND B5), VARIANT LYS-123. Tissue: Brain.
[7]	"Neuropilin-2 and neuropilin-1 are receptors for the 165-amino acid form of vascular endothelial growth factor (VEGF) and of placenta growth factor-2, but only neuropilin-2 functions as a receptor for the 145-amino acid form of VEGF." Gluzman-Poltorak Z., Cohen T., Herzog Y., Neufeld G. J. Biol. Chem. 275:18040-18045(2000) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION.
[8]	"Plexins are a large family of receptors for transmembrane, secreted and GPI-anchored semaphorins in vertebrates." Tamagnone L., Artigiani S., Chen H., He Z., Ming G.-L., Song H.-L., Chedotal A., Winberg M.L., Goodman C.S., Poo M.-M., Tessier-Lavigne M., Comoglio P.M. Cell 99:71-80(1999) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH PLXNB1.
[9]	"Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding." Appleton B.A., Wu P., Maloney J., Yin J., Liang W.C., Stawicki S., Mortara K., Bowman K.K., Elliott J.M., Desmarais W., Bazan J.F., Bagri A., Tessier-Lavigne M., Koch A.W., Wu Y., Watts R.J., Wiesmann C. EMBO J. 26:4902-4912(2007) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS) OF 23-595 ALONE AND IN COMPLEX WITH ANTIBODY, SUBUNIT, CALCIUM-BINDING SITES, DISULFIDE BONDS.
[10]	"De Novo Pathogenic SCN8A Mutation Identified by Whole-Genome Sequencing of a Family Quartet Affected by Infantile Epileptic Encephalopathy and SUDEP." Veeramah K.R., O'Brien J.E., Meisler M.H., Cheng X., Dib-Hajj S.D., Waxman S.G., Talwar D., Girirajan S., Eichler E.E., Restifo L.L., Erickson R.P., Hammer M.F. Am. J. Hum. Genet. 90:502-510(2012) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS CYS-334 AND TRP-428.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF022859 mRNA. Translation: AAC51788.1.
AF022860 mRNA. Translation: AAC51789.1.
AF016098 mRNA. Translation: AAC12922.1.
AF280544 mRNA. Translation: AAG41403.1.
AF280545 mRNA. Translation: AAG41404.1.
AF280546 mRNA. Translation: AAG41405.1.
AF281074 Genomic DNA. Translation: AAG41898.1.
AF281074 Genomic DNA. Translation: AAG41899.1.
AF281074 Genomic DNA. Translation: AAG41900.1.
AC007362 Genomic DNA. Translation: AAX93216.1.
AC007561 Genomic DNA. Translation: AAY14875.1.
CH471063 Genomic DNA. Translation: EAW70362.1.
CH471063 Genomic DNA. Translation: EAW70364.1.
CH471063 Genomic DNA. Translation: EAW70366.1.
CH471063 Genomic DNA. Translation: EAW70368.1.
BC101525 mRNA. Translation: AAI01526.1.
BC104770 mRNA. Translation: AAI04771.1.
BC143238 mRNA. Translation: AAI43239.1.

IPI

IPI00029693.
IPI00218781.
IPI00300890.
IPI00300891.
IPI00398766.
IPI00914842.

RefSeq

NP_003863.2. NM_003872.2.
NP_061004.3. NM_018534.3.
NP_957716.1. NM_201264.1.
NP_957718.1. NM_201266.1.
NP_957719.1. NM_201267.1.
NP_958436.1. NM_201279.1.

UniGene

Hs.471200.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2QQJ	X-ray	1.95	A	275-595	[»]
2QQK	X-ray	2.75	A	23-595	[»]
2QQL	X-ray	3.10	A	23-595	[»]
2QQO	X-ray	2.30	A/B	145-595	[»]

ProteinModelPortal

O60462.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-5745N.

STRING

9606.ENSP00000353582.

PTM databases

PhosphoSite

O60462.

Proteomic databases

PaxDb

O60462.

PRIDE

O60462.

Protocols and materials databases

DNASU

8828.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000272849; ENSP00000272849; ENSG00000118257.
ENST00000355117; ENSP00000347238; ENSG00000118257.
ENST00000357118; ENSP00000349632; ENSG00000118257.
ENST00000357785; ENSP00000350432; ENSG00000118257.
ENST00000360409; ENSP00000353582; ENSG00000118257.
ENST00000412873; ENSP00000407626; ENSG00000118257.
ENST00000417189; ENSP00000387519; ENSG00000118257.

GeneID

8828.

KEGG

hsa:8828.

UCSC

uc002vau.3. human.
uc002vav.3. human.
uc002vay.3. human.

Organism-specific databases

CTD

8828.

GeneCards

GC02P206510.

HGNC

HGNC:8005. NRP2.

HPA

HPA039980.

MIM

602070. gene.

neXtProt

NX_O60462.

PharmGKB

PA31784.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG150152.

HOVERGEN

HBG000502.

InParanoid

O60462.

KO

K06819.

OMA

GHEVRGQ.

OrthoDB

EOG4K6G3M.

PhylomeDB

O60462.

Enzyme and pathway databases

Pathway_Interaction_DB

vegfr1_2_pathway. Signaling events mediated by VEGFR1 and VEGFR2.
vegfr1_pathway. VEGFR1 specific signals.

Reactome

REACT_111045. Developmental Biology.
REACT_111102. Signal Transduction.

Gene expression databases

ArrayExpress

O60462.

Bgee

O60462.

CleanEx

HS_NRP2.

Genevestigator

O60462.

GermOnline

ENSG00000118257. Homo sapiens.

Family and domain databases

Gene3D

2.60.120.290. 2 hits.

InterPro

IPR000421. Coagulation_fac_5/8-C_type_dom.
IPR008985. ConA-like_lec_gl_sf.
IPR000859. CUB_dom.
IPR008979. Galactose-bd-like.
IPR000998. MAM_dom.
IPR014648. Neuropilin.
IPR027143. Neuropilin-2.
IPR022579. Neuropilin1_C.
[Graphical view]

PANTHER

PTHR10127:SF30. PTHR10127:SF30. 1 hit.

Pfam

PF00431. CUB. 2 hits.
PF11980. DUF3481. 1 hit.
PF00754. F5_F8_type_C. 2 hits.
PF00629. MAM. 1 hit.
[Graphical view]

PIRSF

PIRSF036960. Neuropilin. 1 hit.

PRINTS

PR00020. MAMDOMAIN.

SMART

SM00042. CUB. 2 hits.
SM00231. FA58C. 2 hits.
SM00137. MAM. 1 hit.
[Graphical view]

SUPFAM

SSF49899. ConA_like_lec_gl. 1 hit.
SSF49854. CUB. 2 hits.
SSF49785. Gal_bind_like. 2 hits.

PROSITE

PS01180. CUB. 2 hits.
PS01285. FA58C_1. 2 hits.
PS01286. FA58C_2. 2 hits.
PS50022. FA58C_3. 2 hits.
PS50060. MAM_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

NRP2. human.

EvolutionaryTrace

O60462.

GenomeRNAi

8828.

NextBio

33120.

SOURCE

Search...

Entry information

Entry name

NRP2_HUMAN

Accession

Primary (citable) accession number: O60462
Secondary accession number(s): E9PF66 , O14820, O14821, Q53TQ4, Q53TS3, Q7LBX7, Q9H2D4, Q9H2D5, Q9H2E2, Q9H2E3, Q9H2E4

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	November 25, 2008
Last modified:	May 1, 2013
This is version 124 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.