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O60462

- NRP2_HUMAN

UniProt

O60462 - NRP2_HUMAN

Protein

Neuropilin-2

Gene

NRP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 137 (01 Oct 2014)
      Sequence version 2 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi197 – 1971Calcium
    Metal bindingi211 – 2111Calcium
    Metal bindingi252 – 2521Calcium

    GO - Molecular functioni

    1. cytokine binding Source: BHF-UCL
    2. growth factor binding Source: BHF-UCL
    3. heparin binding Source: UniProtKB-KW
    4. metal ion binding Source: UniProtKB-KW
    5. receptor activity Source: ProtInc
    6. semaphorin receptor activity Source: UniProtKB
    7. vascular endothelial growth factor-activated receptor activity Source: UniProtKB

    GO - Biological processi

    1. angiogenesis Source: UniProtKB
    2. axon extension involved in axon guidance Source: BHF-UCL
    3. axon guidance Source: BHF-UCL
    4. cell adhesion Source: UniProtKB
    5. heart development Source: Ensembl
    6. negative chemotaxis Source: Ensembl
    7. nerve development Source: BHF-UCL
    8. neural crest cell migration Source: Ensembl
    9. positive regulation of endothelial cell migration Source: BHF-UCL
    10. positive regulation of endothelial cell proliferation Source: BHF-UCL
    11. semaphorin-plexin signaling pathway involved in neuron projection guidance Source: BHF-UCL
    12. sympathetic ganglion development Source: BHF-UCL
    13. sympathetic neuron projection extension Source: BHF-UCL
    14. sympathetic neuron projection guidance Source: BHF-UCL
    15. vascular endothelial growth factor receptor signaling pathway Source: Reactome

    Keywords - Molecular functioni

    Developmental protein, Receptor

    Keywords - Biological processi

    Differentiation, Neurogenesis

    Keywords - Ligandi

    Calcium, Heparin-binding, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_12473. Neurophilin interactions with VEGF and VEGFR.
    REACT_22329. NrCAM interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuropilin-2
    Alternative name(s):
    Vascular endothelial cell growth factor 165 receptor 2
    Gene namesi
    Name:NRP2
    Synonyms:VEGF165R2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:8005. NRP2.

    Subcellular locationi

    Isoform s9 : Secreted 1 Publication

    GO - Cellular componenti

    1. axon Source: Ensembl
    2. extracellular region Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB
    4. membrane Source: ProtInc
    5. plasma membrane Source: Reactome
    6. semaphorin receptor complex Source: BHF-UCL

    Keywords - Cellular componenti

    Membrane, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31784.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Or 22Sequence AnalysisAdd
    BLAST
    Chaini21 – 931911Neuropilin-2PRO_0000021863Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi28 ↔ 551 Publication
    Disulfide bondi83 ↔ 1051 Publication
    Disulfide bondi149 ↔ 1751 Publication
    Glycosylationi152 – 1521N-linked (GlcNAc...)
    Glycosylationi157 – 1571N-linked (GlcNAc...)
    Disulfide bondi208 ↔ 2301 Publication
    Disulfide bondi277 ↔ 4271 Publication
    Disulfide bondi434 ↔ 5921 Publication
    Glycosylationi629 – 6291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi839 – 8391N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiO60462.
    PaxDbiO60462.
    PRIDEiO60462.

    PTM databases

    PhosphoSiteiO60462.

    Expressioni

    Gene expression databases

    ArrayExpressiO60462.
    BgeeiO60462.
    CleanExiHS_NRP2.
    GenevestigatoriO60462.

    Organism-specific databases

    HPAiHPA039980.

    Interactioni

    Subunit structurei

    Heterodimer with NRP1. Binds PLXNB1.1 Publication

    Protein-protein interaction databases

    BioGridi114355. 2 interactions.
    DIPiDIP-5745N.
    STRINGi9606.ENSP00000353582.

    Structurei

    Secondary structure

    1
    931
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi30 – 334
    Beta strandi38 – 414
    Turni43 – 464
    Beta strandi55 – 606
    Beta strandi66 – 727
    Beta strandi83 – 9513
    Beta strandi98 – 1047
    Beta strandi116 – 12510
    Beta strandi136 – 1427
    Beta strandi151 – 1533
    Beta strandi155 – 1617
    Turni163 – 1664
    Beta strandi174 – 1807
    Beta strandi186 – 19510
    Beta strandi210 – 21910
    Turni220 – 2223
    Beta strandi225 – 2295
    Beta strandi231 – 2333
    Beta strandi238 – 2403
    Beta strandi242 – 2509
    Beta strandi255 – 2573
    Beta strandi259 – 2679
    Turni283 – 2853
    Beta strandi286 – 2883
    Helixi290 – 2923
    Beta strandi293 – 2964
    Beta strandi302 – 3043
    Helixi306 – 3083
    Beta strandi324 – 3263
    Beta strandi329 – 34517
    Turni350 – 3523
    Beta strandi355 – 37117
    Beta strandi376 – 3816
    Beta strandi388 – 3914
    Beta strandi394 – 41724
    Beta strandi420 – 4278
    Helixi429 – 4313
    Beta strandi432 – 4343
    Turni440 – 4423
    Beta strandi443 – 4453
    Helixi447 – 4493
    Beta strandi450 – 4534
    Beta strandi457 – 4593
    Helixi462 – 4654
    Turni467 – 4693
    Beta strandi470 – 4723
    Beta strandi477 – 4804
    Turni483 – 4853
    Beta strandi488 – 50417
    Helixi515 – 5173
    Beta strandi521 – 53414
    Turni541 – 5444
    Beta strandi553 – 5575
    Beta strandi559 – 57820
    Beta strandi585 – 5939

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2QQJX-ray1.95A275-595[»]
    2QQKX-ray2.75A23-595[»]
    2QQLX-ray3.10A23-595[»]
    2QQOX-ray2.30A/B145-595[»]
    ProteinModelPortaliO60462.
    SMRiO60462. Positions 26-595.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO60462.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 864844ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini890 – 93142CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei865 – 88925HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini28 – 142115CUB 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini149 – 267119CUB 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini277 – 427151F5/8 type C 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini434 – 592159F5/8 type C 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini642 – 802161MAMPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi671 – 6744Poly-Ser

    Domaini

    The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin and VEGF binding.

    Sequence similaritiesi

    Belongs to the neuropilin family.Curated
    Contains 2 CUB domains.PROSITE-ProRule annotation
    Contains 2 F5/8 type C domains.PROSITE-ProRule annotation
    Contains 1 MAM domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG150152.
    HOVERGENiHBG000502.
    InParanoidiO60462.
    KOiK06819.
    OMAiNKLHTPL.
    OrthoDBiEOG7ZWD1D.
    PhylomeDBiO60462.
    TreeFamiTF316506.

    Family and domain databases

    Gene3Di2.60.120.260. 2 hits.
    2.60.120.290. 2 hits.
    InterProiIPR000421. Coagulation_fac_5/8-C_type_dom.
    IPR008985. ConA-like_lec_gl_sf.
    IPR000859. CUB_dom.
    IPR008979. Galactose-bd-like.
    IPR000998. MAM_dom.
    IPR014648. Neuropilin.
    IPR022579. Neuropilin1_C.
    [Graphical view]
    PfamiPF00431. CUB. 2 hits.
    PF11980. DUF3481. 1 hit.
    PF00754. F5_F8_type_C. 2 hits.
    PF00629. MAM. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036960. Neuropilin. 1 hit.
    PRINTSiPR00020. MAMDOMAIN.
    SMARTiSM00042. CUB. 2 hits.
    SM00231. FA58C. 2 hits.
    SM00137. MAM. 1 hit.
    [Graphical view]
    SUPFAMiSSF49785. SSF49785. 2 hits.
    SSF49854. SSF49854. 2 hits.
    SSF49899. SSF49899. 1 hit.
    PROSITEiPS01180. CUB. 2 hits.
    PS01285. FA58C_1. 2 hits.
    PS01286. FA58C_2. 2 hits.
    PS50022. FA58C_3. 2 hits.
    PS50060. MAM_2. 1 hit.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform A22 (identifier: O60462-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDMFPLTWVF LALYFSRHQV RGQPDPPCGG RLNSKDAGYI TSPGYPQDYP    50
    SHQNCEWIVY APEPNQKIVL NFNPHFEIEK HDCKYDFIEI RDGDSESADL 100
    LGKHCGNIAP PTIISSGSML YIRFTSDYAR QGAGFSLRYE IFKTGSEDCS 150
    KNFTSPNGTI ESPGFPEKYP HNLDCTFTIL AKPKMEIILQ FLIFDLEHDP 200
    LQVGEGDCKY DWLDIWDGIP HVGPLIGKYC GTKTPSELRS STGILSLTFH 250
    TDMAVAKDGF SARYYLVHQE PLENFQCNVP LGMESGRIAN EQISASSTYS 300
    DGRWTPQQSR LHGDDNGWTP NLDSNKEYLQ VDLRFLTMLT AIATQGAISR 350
    ETQNGYYVKS YKLEVSTNGE DWMVYRHGKN HKVFQANNDA TEVVLNKLHA 400
    PLLTRFVRIR PQTWHSGIAL RLELFGCRVT DAPCSNMLGM LSGLIADSQI 450
    SASSTQEYLW SPSAARLVSS RSGWFPRIPQ AQPGEEWLQV DLGTPKTVKG 500
    VIIQGARGGD SITAVEARAF VRKFKVSYSL NGKDWEYIQD PRTQQPKLFE 550
    GNMHYDTPDI RRFDPIPAQY VRVYPERWSP AGIGMRLEVL GCDWTDSKPT 600
    VETLGPTVKS EETTTPYPTE EEATECGENC SFEDDKDLQL PSGFNCNFDF 650
    LEEPCGWMYD HAKWLRTTWA SSSSPNDRTF PDDRNFLRLQ SDSQREGQYA 700
    RLISPPVHLP RSPVCMEFQY QATGGRGVAL QVVREASQES KLLWVIREDQ 750
    GGEWKHGRII LPSYDMEYQI VFEGVIGKGR SGEIAIDDIR ISTDVPLENC 800
    MEPISAFAGE NFKVDIPEIH EREGYEDEID DEYEVDWSNS SSATSGSGAP 850
    STDKEKSWLY TLDPILITII AMSSLGVLLG ATCAGLLLYC TCSYSGLSSR 900
    SCTTLENYNF ELYDGLKHKV KMNHQKCCSE A 931
    Length:931
    Mass (Da):104,859
    Last modified:November 25, 2008 - v2
    Checksum:iEA5CDBB67F3C4B7D
    GO
    Isoform A0 (identifier: O60462-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         809-830: Missing.

    Show »
    Length:909
    Mass (Da):102,243
    Checksum:i7B0CE20AB8157EE8
    GO
    Isoform A17 (identifier: O60462-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         809-813: Missing.

    Show »
    Length:926
    Mass (Da):104,283
    Checksum:iA6320C5DFA7785A5
    GO
    Isoform B0 (identifier: O60462-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         809-813: Missing.
         814-931: VDIPEIHERE...MNHQKCCSEA → GGTLLPGTEP...KLEQDRGSHC

    Show »
    Length:901
    Mass (Da):101,409
    Checksum:iD9F51B545CEC6DD8
    GO
    Isoform B5 (identifier: O60462-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         814-931: VDIPEIHERE...MNHQKCCSEA → GGTLLPGTEP...KLEQDRGSHC

    Show »
    Length:906
    Mass (Da):101,985
    Checksum:i9C83C9EB47FF74A1
    GO
    Isoform s9 (identifier: O60462-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         548-555: LFEGNMHY → VGCSWRPL
         556-931: Missing.

    Show »
    Length:555
    Mass (Da):62,458
    Checksum:i32CFC8C974D6358E
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti123 – 1231R → K.5 Publications
    Corresponds to variant rs849541 [ dbSNP | Ensembl ].
    VAR_047754
    Natural varianti334 – 3341R → C Rare variant; may act as a phenotype modifier in EIEE13 patients carrying SCN8A mutations. 1 Publication
    Corresponds to variant rs114144673 [ dbSNP | Ensembl ].
    VAR_067537
    Natural varianti428 – 4281R → W Rare variant; may act as a phenotype modifier in EIEE13 patients carrying SCN8A mutations. 1 Publication
    Corresponds to variant rs139711818 [ dbSNP | Ensembl ].
    VAR_067538
    Natural varianti602 – 6021E → K.2 Publications
    Corresponds to variant rs1128169 [ dbSNP | Ensembl ].
    VAR_065167

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei548 – 5558LFEGNMHY → VGCSWRPL in isoform s9. 1 PublicationVSP_044908
    Alternative sequencei556 – 931376Missing in isoform s9. 1 PublicationVSP_044909Add
    BLAST
    Alternative sequencei809 – 83022Missing in isoform A0. 1 PublicationVSP_004342Add
    BLAST
    Alternative sequencei809 – 8135Missing in isoform A17 and isoform B0. 3 PublicationsVSP_004341
    Alternative sequencei814 – 931118VDIPE…CCSEA → GGTLLPGTEPTVDTVPMQPI PAYWYYVMAAGGAVLVLVSV ALALVLHYHRFRYAAKKTDH SITYKTSHYTNGAPLAVEPT LTIKLEQDRGSHC in isoform B0 and isoform B5. 2 PublicationsVSP_041160Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF022859 mRNA. Translation: AAC51788.1.
    AF022860 mRNA. Translation: AAC51789.1.
    AF016098 mRNA. Translation: AAC12922.1.
    AF280544 mRNA. Translation: AAG41403.1.
    AF280545 mRNA. Translation: AAG41404.1.
    AF280546 mRNA. Translation: AAG41405.1.
    AF281074 Genomic DNA. Translation: AAG41898.1.
    AF281074 Genomic DNA. Translation: AAG41899.1.
    AF281074 Genomic DNA. Translation: AAG41900.1.
    AC007362 Genomic DNA. Translation: AAX93216.1.
    AC007561 Genomic DNA. Translation: AAY14875.1.
    CH471063 Genomic DNA. Translation: EAW70362.1.
    CH471063 Genomic DNA. Translation: EAW70364.1.
    CH471063 Genomic DNA. Translation: EAW70366.1.
    CH471063 Genomic DNA. Translation: EAW70368.1.
    BC101525 mRNA. Translation: AAI01526.1.
    BC104770 mRNA. Translation: AAI04771.1.
    BC143238 mRNA. Translation: AAI43239.1.
    CCDSiCCDS2364.1. [O60462-1]
    CCDS2365.1. [O60462-5]
    CCDS46496.1. [O60462-3]
    CCDS46497.1. [O60462-2]
    CCDS46498.1. [O60462-4]
    CCDS46499.1. [O60462-6]
    RefSeqiNP_003863.2. NM_003872.2.
    NP_061004.3. NM_018534.3.
    NP_957716.1. NM_201264.1.
    NP_957718.1. NM_201266.1.
    NP_957719.1. NM_201267.1.
    NP_958436.1. NM_201279.1.
    XP_005246990.2. XM_005246933.2.
    XP_005246991.2. XM_005246934.2.
    UniGeneiHs.471200.

    Genome annotation databases

    EnsembliENST00000272849; ENSP00000272849; ENSG00000118257. [O60462-5]
    ENST00000357118; ENSP00000349632; ENSG00000118257. [O60462-4]
    ENST00000357785; ENSP00000350432; ENSG00000118257. [O60462-3]
    ENST00000360409; ENSP00000353582; ENSG00000118257. [O60462-1]
    ENST00000412873; ENSP00000407626; ENSG00000118257. [O60462-2]
    ENST00000417189; ENSP00000387519; ENSG00000118257. [O60462-6]
    GeneIDi8828.
    KEGGihsa:8828.
    UCSCiuc002vat.3. human.
    uc002vau.3. human. [O60462-5]
    uc002vav.3. human. [O60462-4]
    uc002vaw.3. human. [O60462-1]
    uc002vay.3. human. [O60462-2]
    uc010fud.3. human.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF022859 mRNA. Translation: AAC51788.1 .
    AF022860 mRNA. Translation: AAC51789.1 .
    AF016098 mRNA. Translation: AAC12922.1 .
    AF280544 mRNA. Translation: AAG41403.1 .
    AF280545 mRNA. Translation: AAG41404.1 .
    AF280546 mRNA. Translation: AAG41405.1 .
    AF281074 Genomic DNA. Translation: AAG41898.1 .
    AF281074 Genomic DNA. Translation: AAG41899.1 .
    AF281074 Genomic DNA. Translation: AAG41900.1 .
    AC007362 Genomic DNA. Translation: AAX93216.1 .
    AC007561 Genomic DNA. Translation: AAY14875.1 .
    CH471063 Genomic DNA. Translation: EAW70362.1 .
    CH471063 Genomic DNA. Translation: EAW70364.1 .
    CH471063 Genomic DNA. Translation: EAW70366.1 .
    CH471063 Genomic DNA. Translation: EAW70368.1 .
    BC101525 mRNA. Translation: AAI01526.1 .
    BC104770 mRNA. Translation: AAI04771.1 .
    BC143238 mRNA. Translation: AAI43239.1 .
    CCDSi CCDS2364.1. [O60462-1 ]
    CCDS2365.1. [O60462-5 ]
    CCDS46496.1. [O60462-3 ]
    CCDS46497.1. [O60462-2 ]
    CCDS46498.1. [O60462-4 ]
    CCDS46499.1. [O60462-6 ]
    RefSeqi NP_003863.2. NM_003872.2.
    NP_061004.3. NM_018534.3.
    NP_957716.1. NM_201264.1.
    NP_957718.1. NM_201266.1.
    NP_957719.1. NM_201267.1.
    NP_958436.1. NM_201279.1.
    XP_005246990.2. XM_005246933.2.
    XP_005246991.2. XM_005246934.2.
    UniGenei Hs.471200.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2QQJ X-ray 1.95 A 275-595 [» ]
    2QQK X-ray 2.75 A 23-595 [» ]
    2QQL X-ray 3.10 A 23-595 [» ]
    2QQO X-ray 2.30 A/B 145-595 [» ]
    ProteinModelPortali O60462.
    SMRi O60462. Positions 26-595.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114355. 2 interactions.
    DIPi DIP-5745N.
    STRINGi 9606.ENSP00000353582.

    PTM databases

    PhosphoSitei O60462.

    Proteomic databases

    MaxQBi O60462.
    PaxDbi O60462.
    PRIDEi O60462.

    Protocols and materials databases

    DNASUi 8828.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000272849 ; ENSP00000272849 ; ENSG00000118257 . [O60462-5 ]
    ENST00000357118 ; ENSP00000349632 ; ENSG00000118257 . [O60462-4 ]
    ENST00000357785 ; ENSP00000350432 ; ENSG00000118257 . [O60462-3 ]
    ENST00000360409 ; ENSP00000353582 ; ENSG00000118257 . [O60462-1 ]
    ENST00000412873 ; ENSP00000407626 ; ENSG00000118257 . [O60462-2 ]
    ENST00000417189 ; ENSP00000387519 ; ENSG00000118257 . [O60462-6 ]
    GeneIDi 8828.
    KEGGi hsa:8828.
    UCSCi uc002vat.3. human.
    uc002vau.3. human. [O60462-5 ]
    uc002vav.3. human. [O60462-4 ]
    uc002vaw.3. human. [O60462-1 ]
    uc002vay.3. human. [O60462-2 ]
    uc010fud.3. human.

    Organism-specific databases

    CTDi 8828.
    GeneCardsi GC02P206510.
    HGNCi HGNC:8005. NRP2.
    HPAi HPA039980.
    MIMi 602070. gene.
    neXtProti NX_O60462.
    PharmGKBi PA31784.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG150152.
    HOVERGENi HBG000502.
    InParanoidi O60462.
    KOi K06819.
    OMAi NKLHTPL.
    OrthoDBi EOG7ZWD1D.
    PhylomeDBi O60462.
    TreeFami TF316506.

    Enzyme and pathway databases

    Reactomei REACT_12473. Neurophilin interactions with VEGF and VEGFR.
    REACT_22329. NrCAM interactions.

    Miscellaneous databases

    ChiTaRSi NRP2. human.
    EvolutionaryTracei O60462.
    GeneWikii NRP2.
    GenomeRNAii 8828.
    NextBioi 33120.
    PROi O60462.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O60462.
    Bgeei O60462.
    CleanExi HS_NRP2.
    Genevestigatori O60462.

    Family and domain databases

    Gene3Di 2.60.120.260. 2 hits.
    2.60.120.290. 2 hits.
    InterProi IPR000421. Coagulation_fac_5/8-C_type_dom.
    IPR008985. ConA-like_lec_gl_sf.
    IPR000859. CUB_dom.
    IPR008979. Galactose-bd-like.
    IPR000998. MAM_dom.
    IPR014648. Neuropilin.
    IPR022579. Neuropilin1_C.
    [Graphical view ]
    Pfami PF00431. CUB. 2 hits.
    PF11980. DUF3481. 1 hit.
    PF00754. F5_F8_type_C. 2 hits.
    PF00629. MAM. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036960. Neuropilin. 1 hit.
    PRINTSi PR00020. MAMDOMAIN.
    SMARTi SM00042. CUB. 2 hits.
    SM00231. FA58C. 2 hits.
    SM00137. MAM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49785. SSF49785. 2 hits.
    SSF49854. SSF49854. 2 hits.
    SSF49899. SSF49899. 1 hit.
    PROSITEi PS01180. CUB. 2 hits.
    PS01285. FA58C_1. 2 hits.
    PS01286. FA58C_2. 2 hits.
    PS50022. FA58C_3. 2 hits.
    PS50060. MAM_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III."
      Chen H., Chedotal A., He Z.-G., Goodman C.S., Tessier-Lavigne M.
      Neuron 19:547-559(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A0 AND A17), VARIANTS LYS-123 AND LYS-602.
    2. "Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor."
      Soker S., Takashima S., Miao H.-Q., Neufeld G., Klagsbrun M.
      Cell 92:735-745(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A22), VARIANT LYS-123.
      Tissue: Mammary gland.
    3. "Genomic organization of human neuropilin-1 and neuropilin-2 genes: identification and distribution of splice variants and soluble isoforms."
      Rossignol M., Gagnon M.L., Klagsbrun M.
      Genomics 70:211-222(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS B0; B5 AND S9), VARIANTS LYS-123 AND LYS-602, ALTERNATIVE SPLICING, SUBCELLULAR LOCATION (ISOFORM S9).
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LYS-123.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS B0 AND B5), VARIANT LYS-123.
      Tissue: Brain.
    7. "Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165."
      Gluzman-Poltorak Z., Cohen T., Herzog Y., Neufeld G.
      J. Biol. Chem. 275:18040-18045(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    8. "Plexins are a large family of receptors for transmembrane, secreted and GPI-anchored semaphorins in vertebrates."
      Tamagnone L., Artigiani S., Chen H., He Z., Ming G.-L., Song H.-L., Chedotal A., Winberg M.L., Goodman C.S., Poo M.-M., Tessier-Lavigne M., Comoglio P.M.
      Cell 99:71-80(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PLXNB1.
    9. Cited for: X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS) OF 23-595 ALONE AND IN COMPLEX WITH ANTIBODY, SUBUNIT, CALCIUM-BINDING SITES, DISULFIDE BONDS.
    10. "De Novo Pathogenic SCN8A Mutation Identified by Whole-Genome Sequencing of a Family Quartet Affected by Infantile Epileptic Encephalopathy and SUDEP."
      Veeramah K.R., O'Brien J.E., Meisler M.H., Cheng X., Dib-Hajj S.D., Waxman S.G., Talwar D., Girirajan S., Eichler E.E., Restifo L.L., Erickson R.P., Hammer M.F.
      Am. J. Hum. Genet. 90:502-510(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS CYS-334 AND TRP-428.

    Entry informationi

    Entry nameiNRP2_HUMAN
    AccessioniPrimary (citable) accession number: O60462
    Secondary accession number(s): E9PF66
    , O14820, O14821, Q53TQ4, Q53TS3, Q7LBX7, Q9H2D4, Q9H2D5, Q9H2E2, Q9H2E3, Q9H2E4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 137 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3