Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Neuropilin-2

Gene

NRP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi197CalciumCombined sources1 Publication1
Metal bindingi211CalciumCombined sources1 Publication1
Metal bindingi252CalciumCombined sources1 Publication1

GO - Molecular functioni

  • cytokine binding Source: BHF-UCL
  • growth factor binding Source: BHF-UCL
  • heparin binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • receptor activity Source: ProtInc
  • semaphorin receptor activity Source: UniProtKB
  • vascular endothelial growth factor-activated receptor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Receptor

Keywords - Biological processi

Differentiation, Neurogenesis

Keywords - Ligandi

Calcium, Heparin-binding, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000118257-MONOMER.
ReactomeiR-HSA-194306. Neurophilin interactions with VEGF and VEGFR.
R-HSA-447038. NrCAM interactions.
SIGNORiO60462.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropilin-2
Alternative name(s):
Vascular endothelial cell growth factor 165 receptor 2
Gene namesi
Name:NRP2
Synonyms:VEGF165R2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:8005. NRP2.

Subcellular locationi

  • Membrane 1 Publication; Single-pass type I membrane protein 1 Publication
Isoform s9 :
  • Secreted 1 Publication

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 864ExtracellularSequence analysisAdd BLAST844
Transmembranei865 – 889HelicalSequence analysisAdd BLAST25
Topological domaini890 – 931CytoplasmicSequence analysisAdd BLAST42

GO - Cellular componenti

  • extracellular region Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB
  • membrane Source: ProtInc
  • plasma membrane Source: Reactome
  • semaphorin receptor complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi8828.
PharmGKBiPA31784.

Polymorphism and mutation databases

BioMutaiNRP2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Or 22Sequence analysisAdd BLAST20
ChainiPRO_000002186321 – 931Neuropilin-2Add BLAST911

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 551 Publication
Disulfide bondi83 ↔ 1051 Publication
Disulfide bondi149 ↔ 1751 Publication
Glycosylationi152N-linked (GlcNAc...)Combined sources1
Glycosylationi157N-linked (GlcNAc...)Combined sources1
Disulfide bondi208 ↔ 2301 Publication
Disulfide bondi277 ↔ 4271 Publication
Disulfide bondi434 ↔ 5921 Publication
Glycosylationi629N-linked (GlcNAc...)Sequence analysis1
Glycosylationi839N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO60462.
PaxDbiO60462.
PeptideAtlasiO60462.
PRIDEiO60462.

PTM databases

iPTMnetiO60462.
PhosphoSitePlusiO60462.
SwissPalmiO60462.

Expressioni

Gene expression databases

BgeeiENSG00000118257.
CleanExiHS_NRP2.
ExpressionAtlasiO60462. baseline and differential.
GenevisibleiO60462. HS.

Organism-specific databases

HPAiHPA039980.

Interactioni

Subunit structurei

Heterodimer with NRP1. Binds PLXNB1.1 Publication

GO - Molecular functioni

  • cytokine binding Source: BHF-UCL
  • growth factor binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi114355. 16 interactors.
DIPiDIP-5745N.
STRINGi9606.ENSP00000353582.

Structurei

Secondary structure

1931
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi30 – 33Combined sources4
Beta strandi38 – 41Combined sources4
Turni43 – 46Combined sources4
Beta strandi55 – 60Combined sources6
Beta strandi66 – 72Combined sources7
Beta strandi83 – 95Combined sources13
Beta strandi98 – 104Combined sources7
Beta strandi116 – 125Combined sources10
Beta strandi136 – 142Combined sources7
Beta strandi151 – 153Combined sources3
Beta strandi155 – 161Combined sources7
Turni163 – 166Combined sources4
Beta strandi174 – 180Combined sources7
Beta strandi186 – 195Combined sources10
Beta strandi210 – 219Combined sources10
Turni220 – 222Combined sources3
Beta strandi225 – 229Combined sources5
Beta strandi231 – 233Combined sources3
Beta strandi238 – 240Combined sources3
Beta strandi242 – 250Combined sources9
Beta strandi255 – 257Combined sources3
Beta strandi259 – 267Combined sources9
Turni283 – 285Combined sources3
Beta strandi286 – 288Combined sources3
Helixi290 – 292Combined sources3
Beta strandi293 – 296Combined sources4
Beta strandi302 – 304Combined sources3
Helixi306 – 308Combined sources3
Beta strandi324 – 326Combined sources3
Beta strandi329 – 345Combined sources17
Turni350 – 352Combined sources3
Beta strandi355 – 371Combined sources17
Beta strandi376 – 381Combined sources6
Beta strandi388 – 391Combined sources4
Beta strandi394 – 417Combined sources24
Beta strandi420 – 427Combined sources8
Helixi429 – 431Combined sources3
Beta strandi432 – 434Combined sources3
Turni440 – 442Combined sources3
Beta strandi443 – 445Combined sources3
Helixi447 – 449Combined sources3
Beta strandi450 – 453Combined sources4
Beta strandi456 – 459Combined sources4
Helixi462 – 465Combined sources4
Turni467 – 469Combined sources3
Beta strandi470 – 472Combined sources3
Beta strandi477 – 480Combined sources4
Turni483 – 485Combined sources3
Beta strandi488 – 504Combined sources17
Helixi515 – 517Combined sources3
Beta strandi521 – 534Combined sources14
Turni541 – 544Combined sources4
Beta strandi553 – 557Combined sources5
Beta strandi559 – 578Combined sources20
Beta strandi585 – 593Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QQJX-ray1.95A275-595[»]
2QQKX-ray2.75A23-595[»]
2QQLX-ray3.10A23-595[»]
2QQOX-ray2.30A/B145-595[»]
4QDQX-ray1.95A/B276-595[»]
4QDRX-ray2.40A276-595[»]
4QDSX-ray2.40A/B275-457[»]
5DN2X-ray1.95A/B/C/D275-429[»]
5DQ0X-ray1.80A275-430[»]
ProteinModelPortaliO60462.
SMRiO60462.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO60462.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 142CUB 1PROSITE-ProRule annotationAdd BLAST115
Domaini149 – 267CUB 2PROSITE-ProRule annotationAdd BLAST119
Domaini277 – 427F5/8 type C 1PROSITE-ProRule annotationAdd BLAST151
Domaini434 – 592F5/8 type C 2PROSITE-ProRule annotationAdd BLAST159
Domaini642 – 802MAMPROSITE-ProRule annotationAdd BLAST161

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi671 – 674Poly-Ser4

Domaini

The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin and VEGF binding.

Sequence similaritiesi

Belongs to the neuropilin family.Curated
Contains 2 CUB domains.PROSITE-ProRule annotation
Contains 2 F5/8 type C domains.PROSITE-ProRule annotation
Contains 1 MAM domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHB5. Eukaryota.
ENOG410ZPIE. LUCA.
HOVERGENiHBG000502.
InParanoidiO60462.
KOiK06819.
PhylomeDBiO60462.
TreeFamiTF316506.

Family and domain databases

CDDicd00041. CUB. 2 hits.
cd06263. MAM. 1 hit.
Gene3Di2.60.120.260. 2 hits.
2.60.120.290. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR000859. CUB_dom.
IPR000421. FA58C.
IPR008979. Galactose-bd-like.
IPR000998. MAM_dom.
IPR014648. Neuropilin.
IPR027143. Neuropilin-2.
IPR022579. Neuropilin_C.
[Graphical view]
PANTHERiPTHR10127:SF30. PTHR10127:SF30. 1 hit.
PfamiPF00431. CUB. 2 hits.
PF11980. DUF3481. 1 hit.
PF00754. F5_F8_type_C. 2 hits.
PF00629. MAM. 1 hit.
[Graphical view]
PIRSFiPIRSF036960. Neuropilin. 1 hit.
PRINTSiPR00020. MAMDOMAIN.
SMARTiSM00042. CUB. 2 hits.
SM00231. FA58C. 2 hits.
SM00137. MAM. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 2 hits.
SSF49854. SSF49854. 2 hits.
SSF49899. SSF49899. 1 hit.
PROSITEiPS01180. CUB. 2 hits.
PS01285. FA58C_1. 2 hits.
PS01286. FA58C_2. 2 hits.
PS50022. FA58C_3. 2 hits.
PS50060. MAM_2. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A22 (identifier: O60462-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDMFPLTWVF LALYFSRHQV RGQPDPPCGG RLNSKDAGYI TSPGYPQDYP
60 70 80 90 100
SHQNCEWIVY APEPNQKIVL NFNPHFEIEK HDCKYDFIEI RDGDSESADL
110 120 130 140 150
LGKHCGNIAP PTIISSGSML YIRFTSDYAR QGAGFSLRYE IFKTGSEDCS
160 170 180 190 200
KNFTSPNGTI ESPGFPEKYP HNLDCTFTIL AKPKMEIILQ FLIFDLEHDP
210 220 230 240 250
LQVGEGDCKY DWLDIWDGIP HVGPLIGKYC GTKTPSELRS STGILSLTFH
260 270 280 290 300
TDMAVAKDGF SARYYLVHQE PLENFQCNVP LGMESGRIAN EQISASSTYS
310 320 330 340 350
DGRWTPQQSR LHGDDNGWTP NLDSNKEYLQ VDLRFLTMLT AIATQGAISR
360 370 380 390 400
ETQNGYYVKS YKLEVSTNGE DWMVYRHGKN HKVFQANNDA TEVVLNKLHA
410 420 430 440 450
PLLTRFVRIR PQTWHSGIAL RLELFGCRVT DAPCSNMLGM LSGLIADSQI
460 470 480 490 500
SASSTQEYLW SPSAARLVSS RSGWFPRIPQ AQPGEEWLQV DLGTPKTVKG
510 520 530 540 550
VIIQGARGGD SITAVEARAF VRKFKVSYSL NGKDWEYIQD PRTQQPKLFE
560 570 580 590 600
GNMHYDTPDI RRFDPIPAQY VRVYPERWSP AGIGMRLEVL GCDWTDSKPT
610 620 630 640 650
VETLGPTVKS EETTTPYPTE EEATECGENC SFEDDKDLQL PSGFNCNFDF
660 670 680 690 700
LEEPCGWMYD HAKWLRTTWA SSSSPNDRTF PDDRNFLRLQ SDSQREGQYA
710 720 730 740 750
RLISPPVHLP RSPVCMEFQY QATGGRGVAL QVVREASQES KLLWVIREDQ
760 770 780 790 800
GGEWKHGRII LPSYDMEYQI VFEGVIGKGR SGEIAIDDIR ISTDVPLENC
810 820 830 840 850
MEPISAFAGE NFKVDIPEIH EREGYEDEID DEYEVDWSNS SSATSGSGAP
860 870 880 890 900
STDKEKSWLY TLDPILITII AMSSLGVLLG ATCAGLLLYC TCSYSGLSSR
910 920 930
SCTTLENYNF ELYDGLKHKV KMNHQKCCSE A
Length:931
Mass (Da):104,859
Last modified:November 25, 2008 - v2
Checksum:iEA5CDBB67F3C4B7D
GO
Isoform A0 (identifier: O60462-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     809-830: Missing.

Show »
Length:909
Mass (Da):102,243
Checksum:i7B0CE20AB8157EE8
GO
Isoform A17 (identifier: O60462-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     809-813: Missing.

Show »
Length:926
Mass (Da):104,283
Checksum:iA6320C5DFA7785A5
GO
Isoform B0 (identifier: O60462-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     809-813: Missing.
     814-931: VDIPEIHERE...MNHQKCCSEA → GGTLLPGTEP...KLEQDRGSHC

Show »
Length:901
Mass (Da):101,409
Checksum:iD9F51B545CEC6DD8
GO
Isoform B5 (identifier: O60462-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     814-931: VDIPEIHERE...MNHQKCCSEA → GGTLLPGTEP...KLEQDRGSHC

Show »
Length:906
Mass (Da):101,985
Checksum:i9C83C9EB47FF74A1
GO
Isoform s9 (identifier: O60462-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     548-555: LFEGNMHY → VGCSWRPL
     556-931: Missing.

Show »
Length:555
Mass (Da):62,458
Checksum:i32CFC8C974D6358E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047754123R → K.5 PublicationsCorresponds to variant rs849541dbSNPEnsembl.1
Natural variantiVAR_067537334R → C Rare variant; may act as a phenotype modifier in EIEE13 patients carrying SCN8A mutations. 1 PublicationCorresponds to variant rs114144673dbSNPEnsembl.1
Natural variantiVAR_067538428R → W Rare variant; may act as a phenotype modifier in EIEE13 patients carrying SCN8A mutations. 1 PublicationCorresponds to variant rs139711818dbSNPEnsembl.1
Natural variantiVAR_065167602E → K.2 PublicationsCorresponds to variant rs1128169dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_044908548 – 555LFEGNMHY → VGCSWRPL in isoform s9. 1 Publication8
Alternative sequenceiVSP_044909556 – 931Missing in isoform s9. 1 PublicationAdd BLAST376
Alternative sequenceiVSP_004342809 – 830Missing in isoform A0. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_004341809 – 813Missing in isoform A17 and isoform B0. 3 Publications5
Alternative sequenceiVSP_041160814 – 931VDIPE…CCSEA → GGTLLPGTEPTVDTVPMQPI PAYWYYVMAAGGAVLVLVSV ALALVLHYHRFRYAAKKTDH SITYKTSHYTNGAPLAVEPT LTIKLEQDRGSHC in isoform B0 and isoform B5. 2 PublicationsAdd BLAST118

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022859 mRNA. Translation: AAC51788.1.
AF022860 mRNA. Translation: AAC51789.1.
AF016098 mRNA. Translation: AAC12922.1.
AF280544 mRNA. Translation: AAG41403.1.
AF280545 mRNA. Translation: AAG41404.1.
AF280546 mRNA. Translation: AAG41405.1.
AF281074 Genomic DNA. Translation: AAG41898.1.
AF281074 Genomic DNA. Translation: AAG41899.1.
AF281074 Genomic DNA. Translation: AAG41900.1.
AC007362 Genomic DNA. Translation: AAX93216.1.
AC007561 Genomic DNA. Translation: AAY14875.1.
CH471063 Genomic DNA. Translation: EAW70362.1.
CH471063 Genomic DNA. Translation: EAW70364.1.
CH471063 Genomic DNA. Translation: EAW70366.1.
CH471063 Genomic DNA. Translation: EAW70368.1.
BC101525 mRNA. Translation: AAI01526.1.
BC104770 mRNA. Translation: AAI04771.1.
BC143238 mRNA. Translation: AAI43239.1.
CCDSiCCDS2364.1. [O60462-1]
CCDS2365.1. [O60462-5]
CCDS46496.1. [O60462-3]
CCDS46497.1. [O60462-2]
CCDS46498.1. [O60462-4]
CCDS46499.1. [O60462-6]
RefSeqiNP_003863.2. NM_003872.2.
NP_061004.3. NM_018534.3.
NP_957716.1. NM_201264.1.
NP_957718.1. NM_201266.1.
NP_957719.1. NM_201267.1.
NP_958436.1. NM_201279.1.
XP_005246990.2. XM_005246933.3.
XP_005246991.2. XM_005246934.3.
XP_016860675.1. XM_017005186.1.
UniGeneiHs.471200.
Hs.660596.

Genome annotation databases

EnsembliENST00000272849; ENSP00000272849; ENSG00000118257.
ENST00000417189; ENSP00000387519; ENSG00000118257.
GeneIDi8828.
KEGGihsa:8828.
UCSCiuc002vau.4. human. [O60462-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022859 mRNA. Translation: AAC51788.1.
AF022860 mRNA. Translation: AAC51789.1.
AF016098 mRNA. Translation: AAC12922.1.
AF280544 mRNA. Translation: AAG41403.1.
AF280545 mRNA. Translation: AAG41404.1.
AF280546 mRNA. Translation: AAG41405.1.
AF281074 Genomic DNA. Translation: AAG41898.1.
AF281074 Genomic DNA. Translation: AAG41899.1.
AF281074 Genomic DNA. Translation: AAG41900.1.
AC007362 Genomic DNA. Translation: AAX93216.1.
AC007561 Genomic DNA. Translation: AAY14875.1.
CH471063 Genomic DNA. Translation: EAW70362.1.
CH471063 Genomic DNA. Translation: EAW70364.1.
CH471063 Genomic DNA. Translation: EAW70366.1.
CH471063 Genomic DNA. Translation: EAW70368.1.
BC101525 mRNA. Translation: AAI01526.1.
BC104770 mRNA. Translation: AAI04771.1.
BC143238 mRNA. Translation: AAI43239.1.
CCDSiCCDS2364.1. [O60462-1]
CCDS2365.1. [O60462-5]
CCDS46496.1. [O60462-3]
CCDS46497.1. [O60462-2]
CCDS46498.1. [O60462-4]
CCDS46499.1. [O60462-6]
RefSeqiNP_003863.2. NM_003872.2.
NP_061004.3. NM_018534.3.
NP_957716.1. NM_201264.1.
NP_957718.1. NM_201266.1.
NP_957719.1. NM_201267.1.
NP_958436.1. NM_201279.1.
XP_005246990.2. XM_005246933.3.
XP_005246991.2. XM_005246934.3.
XP_016860675.1. XM_017005186.1.
UniGeneiHs.471200.
Hs.660596.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QQJX-ray1.95A275-595[»]
2QQKX-ray2.75A23-595[»]
2QQLX-ray3.10A23-595[»]
2QQOX-ray2.30A/B145-595[»]
4QDQX-ray1.95A/B276-595[»]
4QDRX-ray2.40A276-595[»]
4QDSX-ray2.40A/B275-457[»]
5DN2X-ray1.95A/B/C/D275-429[»]
5DQ0X-ray1.80A275-430[»]
ProteinModelPortaliO60462.
SMRiO60462.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114355. 16 interactors.
DIPiDIP-5745N.
STRINGi9606.ENSP00000353582.

PTM databases

iPTMnetiO60462.
PhosphoSitePlusiO60462.
SwissPalmiO60462.

Polymorphism and mutation databases

BioMutaiNRP2.

Proteomic databases

MaxQBiO60462.
PaxDbiO60462.
PeptideAtlasiO60462.
PRIDEiO60462.

Protocols and materials databases

DNASUi8828.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000272849; ENSP00000272849; ENSG00000118257.
ENST00000417189; ENSP00000387519; ENSG00000118257.
GeneIDi8828.
KEGGihsa:8828.
UCSCiuc002vau.4. human. [O60462-1]

Organism-specific databases

CTDi8828.
DisGeNETi8828.
GeneCardsiNRP2.
HGNCiHGNC:8005. NRP2.
HPAiHPA039980.
MIMi602070. gene.
neXtProtiNX_O60462.
PharmGKBiPA31784.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHB5. Eukaryota.
ENOG410ZPIE. LUCA.
HOVERGENiHBG000502.
InParanoidiO60462.
KOiK06819.
PhylomeDBiO60462.
TreeFamiTF316506.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000118257-MONOMER.
ReactomeiR-HSA-194306. Neurophilin interactions with VEGF and VEGFR.
R-HSA-447038. NrCAM interactions.
SIGNORiO60462.

Miscellaneous databases

ChiTaRSiNRP2. human.
EvolutionaryTraceiO60462.
GeneWikiiNRP2.
GenomeRNAii8828.
PROiO60462.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000118257.
CleanExiHS_NRP2.
ExpressionAtlasiO60462. baseline and differential.
GenevisibleiO60462. HS.

Family and domain databases

CDDicd00041. CUB. 2 hits.
cd06263. MAM. 1 hit.
Gene3Di2.60.120.260. 2 hits.
2.60.120.290. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR000859. CUB_dom.
IPR000421. FA58C.
IPR008979. Galactose-bd-like.
IPR000998. MAM_dom.
IPR014648. Neuropilin.
IPR027143. Neuropilin-2.
IPR022579. Neuropilin_C.
[Graphical view]
PANTHERiPTHR10127:SF30. PTHR10127:SF30. 1 hit.
PfamiPF00431. CUB. 2 hits.
PF11980. DUF3481. 1 hit.
PF00754. F5_F8_type_C. 2 hits.
PF00629. MAM. 1 hit.
[Graphical view]
PIRSFiPIRSF036960. Neuropilin. 1 hit.
PRINTSiPR00020. MAMDOMAIN.
SMARTiSM00042. CUB. 2 hits.
SM00231. FA58C. 2 hits.
SM00137. MAM. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 2 hits.
SSF49854. SSF49854. 2 hits.
SSF49899. SSF49899. 1 hit.
PROSITEiPS01180. CUB. 2 hits.
PS01285. FA58C_1. 2 hits.
PS01286. FA58C_2. 2 hits.
PS50022. FA58C_3. 2 hits.
PS50060. MAM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNRP2_HUMAN
AccessioniPrimary (citable) accession number: O60462
Secondary accession number(s): E9PF66
, O14820, O14821, Q53TQ4, Q53TS3, Q7LBX7, Q9H2D4, Q9H2D5, Q9H2E2, Q9H2E3, Q9H2E4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 25, 2008
Last modified: November 30, 2016
This is version 158 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.