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O60462

- NRP2_HUMAN

UniProt

O60462 - NRP2_HUMAN

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Protein

Neuropilin-2

Gene

NRP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi197 – 1971Calcium
Metal bindingi211 – 2111Calcium
Metal bindingi252 – 2521Calcium

GO - Molecular functioni

  1. cytokine binding Source: BHF-UCL
  2. growth factor binding Source: BHF-UCL
  3. heparin binding Source: UniProtKB-KW
  4. metal ion binding Source: UniProtKB-KW
  5. receptor activity Source: ProtInc
  6. semaphorin receptor activity Source: UniProtKB
  7. vascular endothelial growth factor-activated receptor activity Source: UniProtKB

GO - Biological processi

  1. angiogenesis Source: UniProtKB
  2. axon extension involved in axon guidance Source: BHF-UCL
  3. axon guidance Source: BHF-UCL
  4. cell adhesion Source: UniProtKB
  5. gonadotrophin-releasing hormone neuronal migration to the hypothalamus Source: Ensembl
  6. heart development Source: Ensembl
  7. negative chemotaxis Source: Ensembl
  8. nerve development Source: BHF-UCL
  9. neural crest cell migration Source: Ensembl
  10. positive regulation of endothelial cell migration Source: BHF-UCL
  11. positive regulation of endothelial cell proliferation Source: BHF-UCL
  12. semaphorin-plexin signaling pathway involved in neuron projection guidance Source: BHF-UCL
  13. sympathetic ganglion development Source: BHF-UCL
  14. sympathetic neuron projection extension Source: BHF-UCL
  15. sympathetic neuron projection guidance Source: BHF-UCL
  16. vascular endothelial growth factor receptor signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Receptor

Keywords - Biological processi

Differentiation, Neurogenesis

Keywords - Ligandi

Calcium, Heparin-binding, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_12473. Neurophilin interactions with VEGF and VEGFR.
REACT_22329. NrCAM interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropilin-2
Alternative name(s):
Vascular endothelial cell growth factor 165 receptor 2
Gene namesi
Name:NRP2
Synonyms:VEGF165R2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:8005. NRP2.

Subcellular locationi

Isoform s9 : Secreted 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 864844ExtracellularSequence AnalysisAdd
BLAST
Transmembranei865 – 88925HelicalSequence AnalysisAdd
BLAST
Topological domaini890 – 93142CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. axon Source: Ensembl
  2. extracellular region Source: UniProtKB-KW
  3. integral component of membrane Source: UniProtKB
  4. membrane Source: ProtInc
  5. plasma membrane Source: Reactome
  6. semaphorin receptor complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31784.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Or 22Sequence AnalysisAdd
BLAST
Chaini21 – 931911Neuropilin-2PRO_0000021863Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi28 ↔ 551 Publication
Disulfide bondi83 ↔ 1051 Publication
Disulfide bondi149 ↔ 1751 Publication
Glycosylationi152 – 1521N-linked (GlcNAc...)
Glycosylationi157 – 1571N-linked (GlcNAc...)
Disulfide bondi208 ↔ 2301 Publication
Disulfide bondi277 ↔ 4271 Publication
Disulfide bondi434 ↔ 5921 Publication
Glycosylationi629 – 6291N-linked (GlcNAc...)Sequence Analysis
Glycosylationi839 – 8391N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO60462.
PaxDbiO60462.
PRIDEiO60462.

PTM databases

PhosphoSiteiO60462.

Expressioni

Gene expression databases

BgeeiO60462.
CleanExiHS_NRP2.
ExpressionAtlasiO60462. baseline and differential.
GenevestigatoriO60462.

Organism-specific databases

HPAiHPA039980.

Interactioni

Subunit structurei

Heterodimer with NRP1. Binds PLXNB1.1 Publication

Protein-protein interaction databases

BioGridi114355. 8 interactions.
DIPiDIP-5745N.
STRINGi9606.ENSP00000353582.

Structurei

Secondary structure

1
931
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi30 – 334Combined sources
Beta strandi38 – 414Combined sources
Turni43 – 464Combined sources
Beta strandi55 – 606Combined sources
Beta strandi66 – 727Combined sources
Beta strandi83 – 9513Combined sources
Beta strandi98 – 1047Combined sources
Beta strandi116 – 12510Combined sources
Beta strandi136 – 1427Combined sources
Beta strandi151 – 1533Combined sources
Beta strandi155 – 1617Combined sources
Turni163 – 1664Combined sources
Beta strandi174 – 1807Combined sources
Beta strandi186 – 19510Combined sources
Beta strandi210 – 21910Combined sources
Turni220 – 2223Combined sources
Beta strandi225 – 2295Combined sources
Beta strandi231 – 2333Combined sources
Beta strandi238 – 2403Combined sources
Beta strandi242 – 2509Combined sources
Beta strandi255 – 2573Combined sources
Beta strandi259 – 2679Combined sources
Turni283 – 2853Combined sources
Beta strandi286 – 2883Combined sources
Helixi290 – 2923Combined sources
Beta strandi293 – 2964Combined sources
Beta strandi302 – 3043Combined sources
Helixi306 – 3083Combined sources
Beta strandi324 – 3263Combined sources
Beta strandi329 – 34517Combined sources
Turni350 – 3523Combined sources
Beta strandi355 – 37117Combined sources
Beta strandi376 – 3816Combined sources
Beta strandi388 – 3914Combined sources
Beta strandi394 – 41724Combined sources
Beta strandi420 – 4278Combined sources
Helixi429 – 4313Combined sources
Beta strandi432 – 4343Combined sources
Turni440 – 4423Combined sources
Beta strandi443 – 4453Combined sources
Helixi447 – 4493Combined sources
Beta strandi450 – 4534Combined sources
Beta strandi457 – 4593Combined sources
Helixi462 – 4654Combined sources
Turni467 – 4693Combined sources
Beta strandi470 – 4723Combined sources
Beta strandi477 – 4804Combined sources
Turni483 – 4853Combined sources
Beta strandi488 – 50417Combined sources
Helixi515 – 5173Combined sources
Beta strandi521 – 53414Combined sources
Turni541 – 5444Combined sources
Beta strandi553 – 5575Combined sources
Beta strandi559 – 57820Combined sources
Beta strandi585 – 5939Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2QQJX-ray1.95A275-595[»]
2QQKX-ray2.75A23-595[»]
2QQLX-ray3.10A23-595[»]
2QQOX-ray2.30A/B145-595[»]
ProteinModelPortaliO60462.
SMRiO60462. Positions 26-595.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO60462.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 142115CUB 1PROSITE-ProRule annotationAdd
BLAST
Domaini149 – 267119CUB 2PROSITE-ProRule annotationAdd
BLAST
Domaini277 – 427151F5/8 type C 1PROSITE-ProRule annotationAdd
BLAST
Domaini434 – 592159F5/8 type C 2PROSITE-ProRule annotationAdd
BLAST
Domaini642 – 802161MAMPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi671 – 6744Poly-Ser

Domaini

The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin and VEGF binding.

Sequence similaritiesi

Belongs to the neuropilin family.Curated
Contains 2 CUB domains.PROSITE-ProRule annotation
Contains 2 F5/8 type C domains.PROSITE-ProRule annotation
Contains 1 MAM domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG150152.
GeneTreeiENSGT00760000119073.
HOVERGENiHBG000502.
InParanoidiO60462.
KOiK06819.
OMAiNKLHTPL.
OrthoDBiEOG7ZWD1D.
PhylomeDBiO60462.
TreeFamiTF316506.

Family and domain databases

Gene3Di2.60.120.260. 2 hits.
2.60.120.290. 2 hits.
InterProiIPR000421. Coagulation_fac_5/8-C_type_dom.
IPR013320. ConA-like_dom.
IPR000859. CUB_dom.
IPR008979. Galactose-bd-like.
IPR000998. MAM_dom.
IPR014648. Neuropilin.
IPR022579. Neuropilin1_C.
[Graphical view]
PfamiPF00431. CUB. 2 hits.
PF11980. DUF3481. 1 hit.
PF00754. F5_F8_type_C. 2 hits.
PF00629. MAM. 1 hit.
[Graphical view]
PIRSFiPIRSF036960. Neuropilin. 1 hit.
PRINTSiPR00020. MAMDOMAIN.
SMARTiSM00042. CUB. 2 hits.
SM00231. FA58C. 2 hits.
SM00137. MAM. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 2 hits.
SSF49854. SSF49854. 2 hits.
SSF49899. SSF49899. 1 hit.
PROSITEiPS01180. CUB. 2 hits.
PS01285. FA58C_1. 2 hits.
PS01286. FA58C_2. 2 hits.
PS50022. FA58C_3. 2 hits.
PS50060. MAM_2. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. Align

Isoform A22 (identifier: O60462-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDMFPLTWVF LALYFSRHQV RGQPDPPCGG RLNSKDAGYI TSPGYPQDYP
60 70 80 90 100
SHQNCEWIVY APEPNQKIVL NFNPHFEIEK HDCKYDFIEI RDGDSESADL
110 120 130 140 150
LGKHCGNIAP PTIISSGSML YIRFTSDYAR QGAGFSLRYE IFKTGSEDCS
160 170 180 190 200
KNFTSPNGTI ESPGFPEKYP HNLDCTFTIL AKPKMEIILQ FLIFDLEHDP
210 220 230 240 250
LQVGEGDCKY DWLDIWDGIP HVGPLIGKYC GTKTPSELRS STGILSLTFH
260 270 280 290 300
TDMAVAKDGF SARYYLVHQE PLENFQCNVP LGMESGRIAN EQISASSTYS
310 320 330 340 350
DGRWTPQQSR LHGDDNGWTP NLDSNKEYLQ VDLRFLTMLT AIATQGAISR
360 370 380 390 400
ETQNGYYVKS YKLEVSTNGE DWMVYRHGKN HKVFQANNDA TEVVLNKLHA
410 420 430 440 450
PLLTRFVRIR PQTWHSGIAL RLELFGCRVT DAPCSNMLGM LSGLIADSQI
460 470 480 490 500
SASSTQEYLW SPSAARLVSS RSGWFPRIPQ AQPGEEWLQV DLGTPKTVKG
510 520 530 540 550
VIIQGARGGD SITAVEARAF VRKFKVSYSL NGKDWEYIQD PRTQQPKLFE
560 570 580 590 600
GNMHYDTPDI RRFDPIPAQY VRVYPERWSP AGIGMRLEVL GCDWTDSKPT
610 620 630 640 650
VETLGPTVKS EETTTPYPTE EEATECGENC SFEDDKDLQL PSGFNCNFDF
660 670 680 690 700
LEEPCGWMYD HAKWLRTTWA SSSSPNDRTF PDDRNFLRLQ SDSQREGQYA
710 720 730 740 750
RLISPPVHLP RSPVCMEFQY QATGGRGVAL QVVREASQES KLLWVIREDQ
760 770 780 790 800
GGEWKHGRII LPSYDMEYQI VFEGVIGKGR SGEIAIDDIR ISTDVPLENC
810 820 830 840 850
MEPISAFAGE NFKVDIPEIH EREGYEDEID DEYEVDWSNS SSATSGSGAP
860 870 880 890 900
STDKEKSWLY TLDPILITII AMSSLGVLLG ATCAGLLLYC TCSYSGLSSR
910 920 930
SCTTLENYNF ELYDGLKHKV KMNHQKCCSE A
Length:931
Mass (Da):104,859
Last modified:November 25, 2008 - v2
Checksum:iEA5CDBB67F3C4B7D
GO
Isoform A0 (identifier: O60462-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     809-830: Missing.

Show »
Length:909
Mass (Da):102,243
Checksum:i7B0CE20AB8157EE8
GO
Isoform A17 (identifier: O60462-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     809-813: Missing.

Show »
Length:926
Mass (Da):104,283
Checksum:iA6320C5DFA7785A5
GO
Isoform B0 (identifier: O60462-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     809-813: Missing.
     814-931: VDIPEIHERE...MNHQKCCSEA → GGTLLPGTEP...KLEQDRGSHC

Show »
Length:901
Mass (Da):101,409
Checksum:iD9F51B545CEC6DD8
GO
Isoform B5 (identifier: O60462-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     814-931: VDIPEIHERE...MNHQKCCSEA → GGTLLPGTEP...KLEQDRGSHC

Show »
Length:906
Mass (Da):101,985
Checksum:i9C83C9EB47FF74A1
GO
Isoform s9 (identifier: O60462-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     548-555: LFEGNMHY → VGCSWRPL
     556-931: Missing.

Show »
Length:555
Mass (Da):62,458
Checksum:i32CFC8C974D6358E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti123 – 1231R → K.5 Publications
Corresponds to variant rs849541 [ dbSNP | Ensembl ].
VAR_047754
Natural varianti334 – 3341R → C Rare variant; may act as a phenotype modifier in EIEE13 patients carrying SCN8A mutations. 1 Publication
Corresponds to variant rs114144673 [ dbSNP | Ensembl ].
VAR_067537
Natural varianti428 – 4281R → W Rare variant; may act as a phenotype modifier in EIEE13 patients carrying SCN8A mutations. 1 Publication
Corresponds to variant rs139711818 [ dbSNP | Ensembl ].
VAR_067538
Natural varianti602 – 6021E → K.2 Publications
Corresponds to variant rs1128169 [ dbSNP | Ensembl ].
VAR_065167

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei548 – 5558LFEGNMHY → VGCSWRPL in isoform s9. 1 PublicationVSP_044908
Alternative sequencei556 – 931376Missing in isoform s9. 1 PublicationVSP_044909Add
BLAST
Alternative sequencei809 – 83022Missing in isoform A0. 1 PublicationVSP_004342Add
BLAST
Alternative sequencei809 – 8135Missing in isoform A17 and isoform B0. 3 PublicationsVSP_004341
Alternative sequencei814 – 931118VDIPE…CCSEA → GGTLLPGTEPTVDTVPMQPI PAYWYYVMAAGGAVLVLVSV ALALVLHYHRFRYAAKKTDH SITYKTSHYTNGAPLAVEPT LTIKLEQDRGSHC in isoform B0 and isoform B5. 2 PublicationsVSP_041160Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022859 mRNA. Translation: AAC51788.1.
AF022860 mRNA. Translation: AAC51789.1.
AF016098 mRNA. Translation: AAC12922.1.
AF280544 mRNA. Translation: AAG41403.1.
AF280545 mRNA. Translation: AAG41404.1.
AF280546 mRNA. Translation: AAG41405.1.
AF281074 Genomic DNA. Translation: AAG41898.1.
AF281074 Genomic DNA. Translation: AAG41899.1.
AF281074 Genomic DNA. Translation: AAG41900.1.
AC007362 Genomic DNA. Translation: AAX93216.1.
AC007561 Genomic DNA. Translation: AAY14875.1.
CH471063 Genomic DNA. Translation: EAW70362.1.
CH471063 Genomic DNA. Translation: EAW70364.1.
CH471063 Genomic DNA. Translation: EAW70366.1.
CH471063 Genomic DNA. Translation: EAW70368.1.
BC101525 mRNA. Translation: AAI01526.1.
BC104770 mRNA. Translation: AAI04771.1.
BC143238 mRNA. Translation: AAI43239.1.
CCDSiCCDS2364.1. [O60462-1]
CCDS2365.1. [O60462-5]
CCDS46496.1. [O60462-3]
CCDS46497.1. [O60462-2]
CCDS46498.1. [O60462-4]
CCDS46499.1. [O60462-6]
RefSeqiNP_003863.2. NM_003872.2.
NP_061004.3. NM_018534.3.
NP_957716.1. NM_201264.1.
NP_957718.1. NM_201266.1.
NP_957719.1. NM_201267.1.
NP_958436.1. NM_201279.1.
XP_005246990.2. XM_005246933.2.
XP_005246991.2. XM_005246934.2.
UniGeneiHs.471200.

Genome annotation databases

EnsembliENST00000272849; ENSP00000272849; ENSG00000118257.
ENST00000417189; ENSP00000387519; ENSG00000118257.
GeneIDi8828.
KEGGihsa:8828.
UCSCiuc002vat.3. human.
uc002vau.3. human. [O60462-5]
uc002vav.3. human. [O60462-4]
uc002vaw.3. human. [O60462-1]
uc002vay.3. human. [O60462-2]
uc010fud.3. human.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022859 mRNA. Translation: AAC51788.1 .
AF022860 mRNA. Translation: AAC51789.1 .
AF016098 mRNA. Translation: AAC12922.1 .
AF280544 mRNA. Translation: AAG41403.1 .
AF280545 mRNA. Translation: AAG41404.1 .
AF280546 mRNA. Translation: AAG41405.1 .
AF281074 Genomic DNA. Translation: AAG41898.1 .
AF281074 Genomic DNA. Translation: AAG41899.1 .
AF281074 Genomic DNA. Translation: AAG41900.1 .
AC007362 Genomic DNA. Translation: AAX93216.1 .
AC007561 Genomic DNA. Translation: AAY14875.1 .
CH471063 Genomic DNA. Translation: EAW70362.1 .
CH471063 Genomic DNA. Translation: EAW70364.1 .
CH471063 Genomic DNA. Translation: EAW70366.1 .
CH471063 Genomic DNA. Translation: EAW70368.1 .
BC101525 mRNA. Translation: AAI01526.1 .
BC104770 mRNA. Translation: AAI04771.1 .
BC143238 mRNA. Translation: AAI43239.1 .
CCDSi CCDS2364.1. [O60462-1 ]
CCDS2365.1. [O60462-5 ]
CCDS46496.1. [O60462-3 ]
CCDS46497.1. [O60462-2 ]
CCDS46498.1. [O60462-4 ]
CCDS46499.1. [O60462-6 ]
RefSeqi NP_003863.2. NM_003872.2.
NP_061004.3. NM_018534.3.
NP_957716.1. NM_201264.1.
NP_957718.1. NM_201266.1.
NP_957719.1. NM_201267.1.
NP_958436.1. NM_201279.1.
XP_005246990.2. XM_005246933.2.
XP_005246991.2. XM_005246934.2.
UniGenei Hs.471200.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2QQJ X-ray 1.95 A 275-595 [» ]
2QQK X-ray 2.75 A 23-595 [» ]
2QQL X-ray 3.10 A 23-595 [» ]
2QQO X-ray 2.30 A/B 145-595 [» ]
ProteinModelPortali O60462.
SMRi O60462. Positions 26-595.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114355. 8 interactions.
DIPi DIP-5745N.
STRINGi 9606.ENSP00000353582.

PTM databases

PhosphoSitei O60462.

Proteomic databases

MaxQBi O60462.
PaxDbi O60462.
PRIDEi O60462.

Protocols and materials databases

DNASUi 8828.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000272849 ; ENSP00000272849 ; ENSG00000118257 .
ENST00000417189 ; ENSP00000387519 ; ENSG00000118257 .
GeneIDi 8828.
KEGGi hsa:8828.
UCSCi uc002vat.3. human.
uc002vau.3. human. [O60462-5 ]
uc002vav.3. human. [O60462-4 ]
uc002vaw.3. human. [O60462-1 ]
uc002vay.3. human. [O60462-2 ]
uc010fud.3. human.

Organism-specific databases

CTDi 8828.
GeneCardsi GC02P206510.
HGNCi HGNC:8005. NRP2.
HPAi HPA039980.
MIMi 602070. gene.
neXtProti NX_O60462.
PharmGKBi PA31784.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG150152.
GeneTreei ENSGT00760000119073.
HOVERGENi HBG000502.
InParanoidi O60462.
KOi K06819.
OMAi NKLHTPL.
OrthoDBi EOG7ZWD1D.
PhylomeDBi O60462.
TreeFami TF316506.

Enzyme and pathway databases

Reactomei REACT_12473. Neurophilin interactions with VEGF and VEGFR.
REACT_22329. NrCAM interactions.

Miscellaneous databases

ChiTaRSi NRP2. human.
EvolutionaryTracei O60462.
GeneWikii NRP2.
GenomeRNAii 8828.
NextBioi 33120.
PROi O60462.
SOURCEi Search...

Gene expression databases

Bgeei O60462.
CleanExi HS_NRP2.
ExpressionAtlasi O60462. baseline and differential.
Genevestigatori O60462.

Family and domain databases

Gene3Di 2.60.120.260. 2 hits.
2.60.120.290. 2 hits.
InterProi IPR000421. Coagulation_fac_5/8-C_type_dom.
IPR013320. ConA-like_dom.
IPR000859. CUB_dom.
IPR008979. Galactose-bd-like.
IPR000998. MAM_dom.
IPR014648. Neuropilin.
IPR022579. Neuropilin1_C.
[Graphical view ]
Pfami PF00431. CUB. 2 hits.
PF11980. DUF3481. 1 hit.
PF00754. F5_F8_type_C. 2 hits.
PF00629. MAM. 1 hit.
[Graphical view ]
PIRSFi PIRSF036960. Neuropilin. 1 hit.
PRINTSi PR00020. MAMDOMAIN.
SMARTi SM00042. CUB. 2 hits.
SM00231. FA58C. 2 hits.
SM00137. MAM. 1 hit.
[Graphical view ]
SUPFAMi SSF49785. SSF49785. 2 hits.
SSF49854. SSF49854. 2 hits.
SSF49899. SSF49899. 1 hit.
PROSITEi PS01180. CUB. 2 hits.
PS01285. FA58C_1. 2 hits.
PS01286. FA58C_2. 2 hits.
PS50022. FA58C_3. 2 hits.
PS50060. MAM_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III."
    Chen H., Chedotal A., He Z.-G., Goodman C.S., Tessier-Lavigne M.
    Neuron 19:547-559(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A0 AND A17), VARIANTS LYS-123 AND LYS-602.
  2. "Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor."
    Soker S., Takashima S., Miao H.-Q., Neufeld G., Klagsbrun M.
    Cell 92:735-745(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A22), VARIANT LYS-123.
    Tissue: Mammary gland.
  3. "Genomic organization of human neuropilin-1 and neuropilin-2 genes: identification and distribution of splice variants and soluble isoforms."
    Rossignol M., Gagnon M.L., Klagsbrun M.
    Genomics 70:211-222(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS B0; B5 AND S9), VARIANTS LYS-123 AND LYS-602, ALTERNATIVE SPLICING, SUBCELLULAR LOCATION (ISOFORM S9).
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LYS-123.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS B0 AND B5), VARIANT LYS-123.
    Tissue: Brain.
  7. "Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165."
    Gluzman-Poltorak Z., Cohen T., Herzog Y., Neufeld G.
    J. Biol. Chem. 275:18040-18045(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  8. "Plexins are a large family of receptors for transmembrane, secreted and GPI-anchored semaphorins in vertebrates."
    Tamagnone L., Artigiani S., Chen H., He Z., Ming G.-L., Song H.-L., Chedotal A., Winberg M.L., Goodman C.S., Poo M.-M., Tessier-Lavigne M., Comoglio P.M.
    Cell 99:71-80(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PLXNB1.
  9. Cited for: X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS) OF 23-595 ALONE AND IN COMPLEX WITH ANTIBODY, SUBUNIT, CALCIUM-BINDING SITES, DISULFIDE BONDS.
  10. "de novo pathogenic SCN8A mutation identified by whole-genome sequencing of a family quartet affected by infantile epileptic encephalopathy and SUDEP."
    Veeramah K.R., O'Brien J.E., Meisler M.H., Cheng X., Dib-Hajj S.D., Waxman S.G., Talwar D., Girirajan S., Eichler E.E., Restifo L.L., Erickson R.P., Hammer M.F.
    Am. J. Hum. Genet. 90:502-510(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS CYS-334 AND TRP-428.

Entry informationi

Entry nameiNRP2_HUMAN
AccessioniPrimary (citable) accession number: O60462
Secondary accession number(s): E9PF66
, O14820, O14821, Q53TQ4, Q53TS3, Q7LBX7, Q9H2D4, Q9H2D5, Q9H2E2, Q9H2E3, Q9H2E4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 25, 2008
Last modified: November 26, 2014
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3