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Protein

Lymphocyte antigen 75

Gene

LY75

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment (By similarity). Causes reduced proliferation of B-lymphocytes.By similarity

GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB-KW
  • receptor activity Source: ProtInc

GO - Biological processi

  • endocytosis Source: UniProtKB-KW
  • immune response Source: ProtInc
  • inflammatory response Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Endocytosis

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Lymphocyte antigen 75
Short name:
Ly-75
Alternative name(s):
C-type lectin domain family 13 member B
DEC-205
gp200-MR6
CD_antigen: CD205
Gene namesi
Name:LY75
Synonyms:CD205, CLEC13B
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:6729. LY75.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 16661639ExtracellularSequence analysisAdd
BLAST
Transmembranei1667 – 169125HelicalSequence analysisAdd
BLAST
Topological domaini1692 – 172231CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30493.

Polymorphism and mutation databases

BioMutaiLY75.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 27271 PublicationAdd
BLAST
Chaini28 – 17221695Lymphocyte antigen 75PRO_0000017552Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi135 – 1351N-linked (GlcNAc...)Sequence analysis
Disulfide bondi169 ↔ 194By similarity
Disulfide bondi183 ↔ 209By similarity
Disulfide bondi247 ↔ 340By similarity
Disulfide bondi317 ↔ 332By similarity
Glycosylationi345 – 3451N-linked (GlcNAc...)Sequence analysis
Glycosylationi377 – 3771N-linked (GlcNAc...)Sequence analysis
Disulfide bondi389 ↔ 485By similarity
Disulfide bondi462 ↔ 477By similarity
Glycosylationi529 – 5291N-linked (GlcNAc...)Sequence analysis
Disulfide bondi597 ↔ 614By similarity
Disulfide bondi840 ↔ 930By similarity
Glycosylationi843 – 8431N-linked (GlcNAc...)Sequence analysis
Glycosylationi865 – 8651N-linked (GlcNAc...)Sequence analysis
Disulfide bondi904 ↔ 922By similarity
Modified residuei933 – 9331PhosphotyrosineCombined sources
Glycosylationi934 – 9341N-linked (GlcNAc...)Sequence analysis
Disulfide bondi1060 ↔ 1080By similarity
Glycosylationi1076 – 10761N-linked (GlcNAc...)Sequence analysis
Glycosylationi1103 – 11031N-linked (GlcNAc...)Sequence analysis
Disulfide bondi1197 ↔ 1211By similarity
Glycosylationi1225 – 12251N-linked (GlcNAc...)Sequence analysis
Glycosylationi1320 – 13201N-linked (GlcNAc...)Sequence analysis
Glycosylationi1392 – 13921N-linked (GlcNAc...)Sequence analysis
Disulfide bondi1488 ↔ 1502By similarity
Glycosylationi1593 – 15931N-linked (GlcNAc...)Sequence analysis
Glycosylationi1626 – 16261N-linked (GlcNAc...)Sequence analysis
Disulfide bondi1635 ↔ 1650By similarity
Modified residuei1703 – 17031PhosphoserineBy similarity
Modified residuei1719 – 17191PhosphoserineBy similarity

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiO60449.
MaxQBiO60449.
PaxDbiO60449.
PRIDEiO60449.

PTM databases

iPTMnetiO60449.
PhosphoSiteiO60449.

Expressioni

Tissue specificityi

Expressed in spleen, thymus, colon and peripheral blood lymphocytes. Detected in myeloid and B-lymphoid cell lines. Isoform 2 and isoform 3 are expressed in malignant Hodgkin lymphoma cells called Hodgkin and Reed-Sternberg (HRS) cells.2 Publications

Gene expression databases

BgeeiO60449.
CleanExiHS_LY75.
GenevisibleiO60449. HS.

Organism-specific databases

HPAiCAB001450.
HPA049108.
HPA054073.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FATE1Q969F03EBI-10186753,EBI-743099

Protein-protein interaction databases

IntActiO60449. 2 interactions.
MINTiMINT-2796723.
STRINGi9606.ENSP00000451511.

Structurei

3D structure databases

ProteinModelPortaliO60449.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 156124Ricin B-type lectinPROSITE-ProRule annotationAdd
BLAST
Domaini164 – 21148Fibronectin type-IIPROSITE-ProRule annotationAdd
BLAST
Domaini225 – 341117C-type lectin 1PROSITE-ProRule annotationAdd
BLAST
Domaini368 – 486119C-type lectin 2PROSITE-ProRule annotationAdd
BLAST
Domaini493 – 625133C-type lectin 3PROSITE-ProRule annotationAdd
BLAST
Domaini652 – 778127C-type lectin 4PROSITE-ProRule annotationAdd
BLAST
Domaini818 – 931114C-type lectin 5PROSITE-ProRule annotationAdd
BLAST
Domaini958 – 1091134C-type lectin 6PROSITE-ProRule annotationAdd
BLAST
Domaini1110 – 1222113C-type lectin 7PROSITE-ProRule annotationAdd
BLAST
Domaini1251 – 1374124C-type lectin 8PROSITE-ProRule annotationAdd
BLAST
Domaini1401 – 1513113C-type lectin 9PROSITE-ProRule annotationAdd
BLAST
Domaini1542 – 1661120C-type lectin 10PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 10 C-type lectin domains.PROSITE-ProRule annotation
Contains 1 fibronectin type-II domain.PROSITE-ProRule annotation
Contains 1 ricin B-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00720000108514.
HOGENOMiHOG000232050.
HOVERGENiHBG045579.
InParanoidiO60449.
KOiK06559.
OMAiGWEWSDH.
OrthoDBiEOG7FFMQR.
PhylomeDBiO60449.
TreeFamiTF316663.

Family and domain databases

Gene3Di2.10.10.10. 1 hit.
3.10.100.10. 10 hits.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR000562. FN_type2_col-bd.
IPR013806. Kringle-like.
IPR000772. Ricin_B_lectin.
[Graphical view]
PfamiPF00040. fn2. 1 hit.
PF00059. Lectin_C. 10 hits.
[Graphical view]
SMARTiSM00034. CLECT. 10 hits.
SM00059. FN2. 1 hit.
SM00458. RICIN. 1 hit.
[Graphical view]
SUPFAMiSSF50370. SSF50370. 1 hit.
SSF56436. SSF56436. 10 hits.
SSF57440. SSF57440. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 10 hits.
PS00023. FN2_1. 1 hit.
PS51092. FN2_2. 1 hit.
PS50231. RICIN_B_LECTIN. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 4 (identifier: O60449-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRTGWATPRR PAGLLMLLFW FFDLAEPSGR AANDPFTIVH GNTGKCIKPV
60 70 80 90 100
YGWIVADDCD ETEDKLWKWV SQHRLFHLHS QKCLGLDITK SVNELRMFSC
110 120 130 140 150
DSSAMLWWKC EHHSLYGAAR YRLALKDGHG TAISNASDVW KKGGSEESLC
160 170 180 190 200
DQPYHEIYTR DGNSYGRPCE FPFLIDGTWH HDCILDEDHS GPWCATTLNY
210 220 230 240 250
EYDRKWGICL KPENGCEDNW EKNEQFGSCY QFNTQTALSW KEAYVSCQNQ
260 270 280 290 300
GADLLSINSA AELTYLKEKE GIAKIFWIGL NQLYSARGWE WSDHKPLNFL
310 320 330 340 350
NWDPDRPSAP TIGGSSCARM DAESGLWQSF SCEAQLPYVC RKPLNNTVEL
360 370 380 390 400
TDVWTYSDTR CDAGWLPNNG FCYLLVNESN SWDKAHAKCK AFSSDLISIH
410 420 430 440 450
SLADVEVVVT KLHNEDIKEE VWIGLKNINI PTLFQWSDGT EVTLTYWDEN
460 470 480 490 500
EPNVPYNKTP NCVSYLGELG QWKVQSCEEK LKYVCKRKGE KLNDASSDKM
510 520 530 540 550
CPPDEGWKRH GETCYKIYED EVPFGTNCNL TITSRFEQEY LNDLMKKYDK
560 570 580 590 600
SLRKYFWTGL RDVDSCGEYN WATVGGRRRA VTFSNWNFLE PASPGGCVAM
610 620 630 640 650
STGKSVGKWE VKDCRSFKAL SICKKMSGPL GPEEASPKPD DPCPEGWQSF
660 670 680 690 700
PASLSCYKVF HAERIVRKRN WEEAERFCQA LGAHLSSFSH VDEIKEFLHF
710 720 730 740 750
LTDQFSGQHW LWIGLNKRSP DLQGSWQWSD RTPVSTIIMP NEFQQDYDIR
760 770 780 790 800
DCAAVKVFHR PWRRGWHFYD DREFIYLRPF ACDTKLEWVC QIPKGRTPKT
810 820 830 840 850
PDWYNPDRAG IHGPPLIIEG SEYWFVADLH LNYEEAVLYC ASNHSFLATI
860 870 880 890 900
TSFVGLKAIK NKIANISGDG QKWWIRISEW PIDDHFTYSR YPWHRFPVTF
910 920 930 940 950
GEECLYMSAK TWLIDLGKPT DCSTKLPFIC EKYNVSSLEK YSPDSAAKVQ
960 970 980 990 1000
CSEQWIPFQN KCFLKIKPVS LTFSQASDTC HSYGGTLPSV LSQIEQDFIT
1010 1020 1030 1040 1050
SLLPDMEATL WIGLRWTAYE KINKWTDNRE LTYSNFHPLL VSGRLRIPEN
1060 1070 1080 1090 1100
FFEEESRYHC ALILNLQKSP FTGTWNFTSC SERHFVSLCQ KYSEVKSRQT
1110 1120 1130 1140 1150
LQNASETVKY LNNLYKIIPK TLTWHSAKRE CLKSNMQLVS ITDPYQQAFL
1160 1170 1180 1190 1200
SVQALLHNSS LWIGLFSQDD ELNFGWSDGK RLHFSRWAET NGQLEDCVVL
1210 1220 1230 1240 1250
DTDGFWKTVD CNDNQPGAIC YYSGNETEKE VKPVDSVKCP SPVLNTPWIP
1260 1270 1280 1290 1300
FQNCCYNFII TKNRHMATTQ DEVHTKCQKL NPKSHILSIR DEKENNFVLE
1310 1320 1330 1340 1350
QLLYFNYMAS WVMLGITYRN KSLMWFDKTP LSYTHWRAGR PTIKNEKFLA
1360 1370 1380 1390 1400
GLSTDGFWDI QTFKVIEEAV YFHQHSILAC KIEMVDYKEE YNTTLPQFMP
1410 1420 1430 1440 1450
YEDGIYSVIQ KKVTWYEALN MCSQSGGHLA SVHNQNGQLF LEDIVKRDGF
1460 1470 1480 1490 1500
PLWVGLSSHD GSESSFEWSD GSTFDYIPWK GQTSPGNCVL LDPKGTWKHE
1510 1520 1530 1540 1550
KCNSVKDGAI CYKPTKSKKL SRLTYSSRCP AAKENGSRWI QYKGHCYKSD
1560 1570 1580 1590 1600
QALHSFSEAK KLCSKHDHSA TIVSIKDEDE NKFVSRLMRE NNNITMRVWL
1610 1620 1630 1640 1650
GLSQHSVDQS WSWLDGSEVT FVKWENKSKS GVGRCSMLIA SNETWKKVEC
1660 1670 1680 1690 1700
EHGFGRVVCK VPLGPDYTAI AIIVATLSIL VLMGGLIWFL FQRHRLHLAG
1710 1720
FSSVRYAQGV NEDEIMLPSF HD
Length:1,722
Mass (Da):198,311
Last modified:January 11, 2011 - v3
Checksum:i4BC17EC646BF016F
GO
Isoform 2 (identifier: O60449-2) [UniParc]FASTAAdd to basket

Also known as: Fusion protein variant V34-2

The sequence of this isoform differs from the canonical sequence as follows:
     1664-1722: GPDYTAIAII...DEIMLPSFHD → DCPSSTWIQF...EENEYPVQFD

Note: Produced by intergenic splicing of LY75 and CD302.
Show »
Length:1,873
Mass (Da):215,781
Checksum:iFCB3376C05559AD1
GO
Isoform 5 (identifier: Q8IX05-2) [UniParc]FASTAAdd to basket

The sequence of this isoform can be found in the external entry Q8IX05.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:174
Mass (Da):19,562
GO
Isoform 3 (identifier: O60449-3) [UniParc]FASTAAdd to basket

Also known as: Fusion protein variant V33-2

The sequence of this isoform differs from the canonical sequence as follows:
     1608-1722: DQSWSWLDGS...DEIMLPSFHD → DCPSSTWIQF...EENEYPVQFD

Note: Produced by intergenic splicing of LY75 and CD302.
Show »
Length:1,817
Mass (Da):209,438
Checksum:iA9B77FE92CC444D4
GO
Isoform 1 (identifier: Q8IX05-1) [UniParc]FASTAAdd to basket

The sequence of this isoform can be found in the external entry Q8IX05.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Produced by intergenic splicing of LY75 and CD302.
Length:232
Mass (Da):26,183
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti20 – 201W → R.
Corresponds to variant rs35284483 [ dbSNP | Ensembl ].
VAR_056156
Natural varianti268 – 2681E → D.1 Publication
Corresponds to variant rs2271381 [ dbSNP | Ensembl ].
VAR_027824
Natural varianti486 – 4861K → M.
Corresponds to variant rs2729709 [ dbSNP | Ensembl ].
VAR_027825
Natural varianti666 – 6661V → A.
Corresponds to variant rs34020639 [ dbSNP | Ensembl ].
VAR_056157
Natural varianti692 – 6921D → N.
Corresponds to variant rs1397706 [ dbSNP | Ensembl ].
VAR_024522
Natural varianti807 – 8071D → E.1 Publication
Corresponds to variant rs3951216 [ dbSNP | Ensembl ].
VAR_027826
Natural varianti884 – 8841D → A.
Corresponds to variant rs3815875 [ dbSNP | Ensembl ].
VAR_027827
Natural varianti1202 – 12021T → S.
Corresponds to variant rs2303549 [ dbSNP | Ensembl ].
VAR_027828
Natural varianti1321 – 13211K → N.2 Publications
Corresponds to variant rs12692566 [ dbSNP | Ensembl ].
VAR_027829
Natural varianti1347 – 13471K → R.
Corresponds to variant rs17827158 [ dbSNP | Ensembl ].
VAR_027830
Natural varianti1391 – 13911Y → H.
Corresponds to variant rs2059696 [ dbSNP | Ensembl ].
VAR_027831
Natural varianti1393 – 13931T → I.
Corresponds to variant rs35941588 [ dbSNP | Ensembl ].
VAR_056158

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1608 – 1722115DQSWS…PSFHD → DCPSSTWIQFQDSCYIFLQE AIKVESIEDVRNQCTDHGAD MISIHNEEENAFILDTLKKQ WKGPDDILLGMFYDTDDASF KWFDNSNMTFDKWTDQDDDE DLVDTCAFLHIKTGEWKKGN CEVSSVEGTLCKTAIPYKRK YLSDNHILISALVIASTVIL TVLGAIIWFLYKKHSDSRFT TVFSTAPQSPYNEDCVLVVG EENEYPVQFD in isoform 3. 1 PublicationVSP_020908Add
BLAST
Alternative sequencei1664 – 172259GPDYT…PSFHD → DCPSSTWIQFQDSCYIFLQE AIKVESIEDVRNQCTDHGAD MISIHNEEENAFILDTLKKQ WKGPDDILLGMFYDTDDASF KWFDNSNMTFDKWTDQDDDE DLVDTCAFLHIKTGEWKKGN CEVSSVEGTLCKTAIPYKRK YLSDNHILISALVIASTVIL TVLGAIIWFLYKKHSDSRFT TVFSTAPQSPYNEDCVLVVG EENEYPVQFD in isoform 2. 1 PublicationVSP_020909Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF064827 mRNA. Translation: AAC62622.1.
AF011333 mRNA. Translation: AAC17636.1.
AY184222 mRNA. Translation: AAN85434.1.
AY314006 mRNA. Translation: AAP79899.1.
AC009961 Genomic DNA. Translation: AAY14943.1.
AC093873 Genomic DNA. Translation: AAY24189.1.
CCDSiCCDS2211.1. [O60449-1]
RefSeqiNP_001185688.1. NM_001198759.1. [O60449-2]
NP_001185689.1. NM_001198760.1. [O60449-3]
NP_002340.2. NM_002349.3. [O60449-1]
UniGeneiHs.153563.

Genome annotation databases

EnsembliENST00000263636; ENSP00000263636; ENSG00000054219. [O60449-1]
GeneIDi100526664.
4065.
KEGGihsa:100526664.
hsa:4065.
UCSCiuc002ubc.6. human. [O60449-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

DEC-205

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF064827 mRNA. Translation: AAC62622.1.
AF011333 mRNA. Translation: AAC17636.1.
AY184222 mRNA. Translation: AAN85434.1.
AY314006 mRNA. Translation: AAP79899.1.
AC009961 Genomic DNA. Translation: AAY14943.1.
AC093873 Genomic DNA. Translation: AAY24189.1.
CCDSiCCDS2211.1. [O60449-1]
RefSeqiNP_001185688.1. NM_001198759.1. [O60449-2]
NP_001185689.1. NM_001198760.1. [O60449-3]
NP_002340.2. NM_002349.3. [O60449-1]
UniGeneiHs.153563.

3D structure databases

ProteinModelPortaliO60449.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO60449. 2 interactions.
MINTiMINT-2796723.
STRINGi9606.ENSP00000451511.

PTM databases

iPTMnetiO60449.
PhosphoSiteiO60449.

Polymorphism and mutation databases

BioMutaiLY75.

Proteomic databases

EPDiO60449.
MaxQBiO60449.
PaxDbiO60449.
PRIDEiO60449.

Protocols and materials databases

DNASUi4065.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263636; ENSP00000263636; ENSG00000054219. [O60449-1]
GeneIDi100526664.
4065.
KEGGihsa:100526664.
hsa:4065.
UCSCiuc002ubc.6. human. [O60449-1]

Organism-specific databases

CTDi100526664.
4065.
GeneCardsiLY75.
H-InvDBHIX0024086.
HGNCiHGNC:6729. LY75.
HPAiCAB001450.
HPA049108.
HPA054073.
MIMi604524. gene.
neXtProtiNX_O60449.
PharmGKBiPA30493.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00720000108514.
HOGENOMiHOG000232050.
HOVERGENiHBG045579.
InParanoidiO60449.
KOiK06559.
OMAiGWEWSDH.
OrthoDBiEOG7FFMQR.
PhylomeDBiO60449.
TreeFamiTF316663.

Miscellaneous databases

GeneWikiiLY75.
NextBioi15936.
SOURCEiSearch...

Gene expression databases

BgeeiO60449.
CleanExiHS_LY75.
GenevisibleiO60449. HS.

Family and domain databases

Gene3Di2.10.10.10. 1 hit.
3.10.100.10. 10 hits.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR000562. FN_type2_col-bd.
IPR013806. Kringle-like.
IPR000772. Ricin_B_lectin.
[Graphical view]
PfamiPF00040. fn2. 1 hit.
PF00059. Lectin_C. 10 hits.
[Graphical view]
SMARTiSM00034. CLECT. 10 hits.
SM00059. FN2. 1 hit.
SM00458. RICIN. 1 hit.
[Graphical view]
SUPFAMiSSF50370. SSF50370. 1 hit.
SSF56436. SSF56436. 10 hits.
SSF57440. SSF57440. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 10 hits.
PS00023. FN2_1. 1 hit.
PS51092. FN2_2. 1 hit.
PS50231. RICIN_B_LECTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The gp200-MR6 molecule which is functionally associated with the IL-4 receptor modulates B cell phenotype and is a novel member of the human macrophage mannose receptor family."
    McKay P.F., Imami N., Johns M., Taylor-Fishwick D.A., Sedibane L.M., Totty N.F., Hsuan J.J., Palmer D.B., George A.J.T., Foxwell B.M.J., Ritter M.A.
    Eur. J. Immunol. 28:4071-4083(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), PARTIAL PROTEIN SEQUENCE, TISSUE SPECIFICITY, GLYCOSYLATION, VARIANTS ASP-268 AND GLU-807.
    Tissue: Thymus.
  2. "cDNA cloning of human DEC-205, a putative antigen-uptake receptor on dendritic cells."
    Kato M., Neil T.K., Clark G.J., Morris C.M., Sorg R.V., Hart D.N.J.
    Immunogenetics 47:442-450(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), VARIANT ASN-1321.
  3. "Hodgkin's lymphoma cell lines express a fusion protein encoded by intergenically spliced mRNA for the multilectin receptor DEC-205 (CD205) and a novel C-type lectin receptor DCL-1."
    Kato M., Khan S., Gonzalez N., O'Neill B.P., McDonald K.J., Cooper B.J., Angel N.Z., Hart D.N.J.
    J. Biol. Chem. 278:34035-34041(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), TISSUE SPECIFICITY, VARIANT ASN-1321.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-933, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiLY75_HUMAN
AccessioniPrimary (citable) accession number: O60449
Secondary accession number(s): O75913
, Q53R46, Q53TF5, Q7Z575, Q7Z577
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: January 11, 2011
Last modified: March 16, 2016
This is version 141 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Isoform 2 and isoform 3 are produced in HRS cells by a transcriptional control mechanism which cotranscribe an mRNA containing LY75 and CD302 prior to generating the intergenically spliced mRNA to produce LY75/CD302 fusion proteins.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.