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Protein

Periplakin

Gene

PPL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling.1 Publication

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • structural constituent of cytoskeleton Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Keratinization

Enzyme and pathway databases

BioCyciZFISH:ENSG00000118898-MONOMER.
ReactomeiR-HSA-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Periplakin
Alternative name(s):
190 kDa paraneoplastic pemphigus antigen
195 kDa cornified envelope precursor protein
Gene namesi
Name:PPL
Synonyms:KIAA0568
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:9273. PPL.

Subcellular locationi

GO - Cellular componenti

  • cell-cell adherens junction Source: BHF-UCL
  • cytoskeleton Source: ProtInc
  • desmosome Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
  • mitochondrion Source: UniProtKB-SubCell
  • nucleus Source: UniProtKB-SubCell
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Mitochondrion, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi5493.
OpenTargetsiENSG00000118898.
PharmGKBiPA33602.

Polymorphism and mutation databases

BioMutaiPPL.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000781491 – 1756PeriplakinAdd BLAST1756

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineCombined sources1
Modified residuei465PhosphoserineCombined sources1
Modified residuei887PhosphoserineCombined sources1
Modified residuei949PhosphoserineCombined sources1
Modified residuei1584PhosphoserineCombined sources1
Modified residuei1657PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO60437.
MaxQBiO60437.
PaxDbiO60437.
PeptideAtlasiO60437.
PRIDEiO60437.

PTM databases

iPTMnetiO60437.
PhosphoSitePlusiO60437.
SwissPalmiO60437.

Expressioni

Tissue specificityi

Expressed in stratified squamous epithelia and in some other epithelia.2 Publications

Inductioni

During differentiation of epidermal keratinocytes.1 Publication

Gene expression databases

BgeeiENSG00000118898.
CleanExiHS_PPL.
ExpressionAtlasiO60437. baseline and differential.
GenevisibleiO60437. HS.

Organism-specific databases

HPAiHPA042550.
HPA059859.

Interactioni

Subunit structurei

Homodimer or a heterodimer with EVPL. Interacts with PPHLN1 and VIM. Binds to the PH domain of AKT1. Interacts with FCGR1A.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AHCYL1O438653EBI-368321,EBI-2371423
AKT1P317492EBI-368321,EBI-296087
ALAS1P131965EBI-368321,EBI-3905054
ANXA9O760276EBI-368321,EBI-720960
CEP57L1Q8IYX8-23EBI-368321,EBI-10181988
RAB3IPQ96QF03EBI-368321,EBI-747844
RALBP1Q153113EBI-368321,EBI-749285
TRAF2Q129335EBI-368321,EBI-355744
TRIM27P143733EBI-368321,EBI-719493
TSC22D4Q9Y3Q83EBI-368321,EBI-739485
VIMP086703EBI-368321,EBI-353844
ZSCAN1Q8NBB43EBI-368321,EBI-5292994

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL

Protein-protein interaction databases

BioGridi111488. 57 interactors.
IntActiO60437. 30 interactors.
MINTiMINT-1181651.
STRINGi9606.ENSP00000340510.

Structurei

Secondary structure

11756
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi1655 – 1661Combined sources7
Turni1663 – 1665Combined sources3
Helixi1671 – 1676Combined sources6
Helixi1682 – 1689Combined sources8
Beta strandi1693 – 1701Combined sources9
Beta strandi1706 – 1712Combined sources7
Turni1713 – 1716Combined sources4
Beta strandi1717 – 1721Combined sources5
Helixi1722 – 1726Combined sources5
Helixi1732 – 1739Combined sources8
Helixi1745 – 1753Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4Q28X-ray2.64A/B/C/D1655-1756[»]
ProteinModelPortaliO60437.
SMRiO60437.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati216 – 317Spectrin 1Add BLAST102
Repeati323 – 485Spectrin 2Add BLAST163
Repeati505 – 612Spectrin 3Add BLAST108
Repeati733 – 861Spectrin 4Add BLAST129
Repeati1651 – 1685Plectin 1Add BLAST35
Repeati1700 – 1735Plectin 2Add BLAST36

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili16 – 125Sequence analysisAdd BLAST110
Coiled coili188 – 389Sequence analysisAdd BLAST202
Coiled coili585 – 820Sequence analysisAdd BLAST236
Coiled coili886 – 1645Sequence analysisAdd BLAST760

Sequence similaritiesi

Belongs to the plakin or cytolinker family.Curated
Contains 2 plectin repeats.Curated
Contains 4 spectrin repeats.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IQBN. Eukaryota.
ENOG410YHVZ. LUCA.
GeneTreeiENSGT00760000119163.
HOGENOMiHOG000168302.
HOVERGENiHBG053564.
InParanoidiO60437.
KOiK10386.
OMAiSYEPQET.
OrthoDBiEOG091G00CT.
PhylomeDBiO60437.
TreeFamiTF342779.

Family and domain databases

InterProiIPR001101. Plectin_repeat.
IPR018159. Spectrin/alpha-actinin.
[Graphical view]
SMARTiSM00250. PLEC. 2 hits.
SM00150. SPEC. 5 hits.
[Graphical view]
SUPFAMiSSF75399. SSF75399. 1 hit.

Sequencei

Sequence statusi: Complete.

O60437-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSLFRKRNK GKYSPTVQTR SISNKELSEL IEQLQKNADQ VEKNIVDTEA
60 70 80 90 100
KMQSDLARLQ EGRQPEHRDV TLQKVLDSEK LLYVLEADAA IAKHMKHPQG
110 120 130 140 150
DMIAEDIRQL KERVTNLRGK HKQIYRLAVK EVDPQVNWAA LVEEKLDKLN
160 170 180 190 200
NQSFGTDLPL VDHQVEEHNI FHNEVKAIGP HLAKDGDKEQ NSELRAKYQK
210 220 230 240 250
LLAASQARQQ HLSSLQDYMQ RCTNELYWLD QQAKGRMQYD WSDRNLDYPS
260 270 280 290 300
RRRQYENFIN RNLEAKEERI NKLHSEGDQL LAAEHPGRNS IEAHMEAVHA
310 320 330 340 350
DWKEYLNLLI CEESHLKYME DYHQFHEDVK DAQELLRKVD SDLNQKYGPD
360 370 380 390 400
FKDRYQIELL LRELDDQEKV LDKYEDVVQG LQKRGQQVVP LKYRRETPLK
410 420 430 440 450
PIPVEALCDF EGEQGLISRG YSYTLQKNNG ESWELMDSAG NKLIAPAVCF
460 470 480 490 500
VIPPTDPEAL ALADSLGSQY RSVRQKAAGS KRTLQQRYEV LKTENPGDAS
510 520 530 540 550
DLQGRQLLAG LDKVASDLDR QEKAITGILR PPLEQGRAVQ DSAERAKDLK
560 570 580 590 600
NITNELLRIE PEKTRSTAEG EAFIQALPGS GTTPLLRTRV EDTNRKYEHL
610 620 630 640 650
LQLLDLAQEK VDVANRLEKS LQQSWELLAT HENHLNQDDT VPESSRVLDS
660 670 680 690 700
KGQELAAMAC ELQAQKSLLG EVEQNLQAAK QCSSTLASRF QEHCPDLERQ
710 720 730 740 750
EAEVHKLGQR FNNLRQQVER RAQSLQSAKA AYEHFHRGHD HVLQFLVSIP
760 770 780 790 800
SYEPQETDSL SQMETKLKNQ KNLLDEIASR EQEVQKICAN SQQYQQAVKD
810 820 830 840 850
YELEAEKLRS LLDLENGRRS HVSKRARLQS PATKVKEEEA ALAAKFTEVY
860 870 880 890 900
AINRQRLQNL EFALNLLRQQ PEVEVTHETL QRNRPDSGVE EAWKIRKELD
910 920 930 940 950
EETERRRQLE NEVKSTQEEI WTLRNQGPQE SVVRKEVLKK VPDPVLEESF
960 970 980 990 1000
QQLQRTLAEE QHKNQLLQEE LEALQLQLRA LEQETRDGGQ EYVVKEVLRI
1010 1020 1030 1040 1050
EPDRAQADEV LQLREELEAL RRQKGAREAE VLLLQQRVAA LAEEKSRAQE
1060 1070 1080 1090 1100
KVTEKEVVKL QNDPQLEAEY QQLQEDHQRQ DQLREKQEEE LSFLQDKLKR
1110 1120 1130 1140 1150
LEKERAMAEG KITVKEVLKV EKDAATEREV SDLTRQYEDE AAKARASQRE
1160 1170 1180 1190 1200
KTELLRKIWA LEEENAKVVV QEKVREIVRP DPKAESEVAN LRLELVEQER
1210 1220 1230 1240 1250
KYRGAEEQLR SYQSELEALR RRGPQVEVKE VTKEVIKYKT DPEMEKELQR
1260 1270 1280 1290 1300
LREEIVDKTR LIERCDLEIY QLKKEIQALK DTKPQVQTKE VVQEILQFQE
1310 1320 1330 1340 1350
DPQTKEEVAS LRAKLSEEQK KQVDLERERA SQEEQIARKE EELSRVKERV
1360 1370 1380 1390 1400
VQQEVVRYEE EPGLRAEASA FAESIDVELR QIDKLRAELR RLQRRRTELE
1410 1420 1430 1440 1450
RQLEELERER QARREAEREV QRLQQRLAAL EQEEAEAREK VTHTQKVVLQ
1460 1470 1480 1490 1500
QDPQQAREHA LLRLQLEEEQ HRRQLLEGEL ETLRRKLAAL EKAEVKEKVV
1510 1520 1530 1540 1550
LSESVQVEKG DTEQEIQRLK SSLEEESRSK RELDVEVSRL EARLSELEFH
1560 1570 1580 1590 1600
NSKSSKELDF LREENHKLQL ERQNLQLETR RLQSEINMAA TETRDLRNMT
1610 1620 1630 1640 1650
VADSGTNHDS RLWSLERELD DLKRLSKDKD LEIDELQKRL GSVAVKREQR
1660 1670 1680 1690 1700
ENHLRRSIVV IHPDTGRELS PEEAHRAGLI DWNMFVKLRS QECDWEEISV
1710 1720 1730 1740 1750
KGPNGESSVI HDRKSGKKFS IEEALQSGRL TPAQYDRYVN KDMSIQELAV

LVSGQK
Length:1,756
Mass (Da):204,747
Last modified:January 11, 2011 - v4
Checksum:iEA7EAF3E756D78B4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti657A → P in AAC39668 (PubMed:9521878).Curated1
Sequence conflicti657A → P in AAD17459 (PubMed:10051401).Curated1
Sequence conflicti994V → F in AAC17738 (PubMed:9412476).Curated1
Sequence conflicti1663P → L in AAC17738 (PubMed:9412476).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055125520R → Q.Corresponds to variant rs8063727dbSNPEnsembl.1
Natural variantiVAR_055126572A → S.Corresponds to variant rs35300633dbSNPEnsembl.1
Natural variantiVAR_055127589R → Q.4 PublicationsCorresponds to variant rs1049205dbSNPEnsembl.1
Natural variantiVAR_055128631H → Y.Corresponds to variant rs34936263dbSNPEnsembl.1
Natural variantiVAR_055129819R → S.6 PublicationsCorresponds to variant rs2734742dbSNPEnsembl.1
Natural variantiVAR_055130891E → Q.Corresponds to variant rs35869286dbSNPEnsembl.1
Natural variantiVAR_0551311007A → V.Corresponds to variant rs2075639dbSNPEnsembl.1
Natural variantiVAR_0551321199E → Q.Corresponds to variant rs12446946dbSNPEnsembl.1
Natural variantiVAR_0551331573Q → E.3 PublicationsCorresponds to variant rs2037912dbSNPEnsembl.1
Natural variantiVAR_0551341754G → R.Corresponds to variant rs35865314dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001691 mRNA. Translation: AAC17738.1.
AF013717 mRNA. Translation: AAC39668.1.
AF041004
, AF040999, AF041000, AF041002, AF041003 Genomic DNA. Translation: AAD17459.1.
AC027687 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85248.1.
BC114620 mRNA. Translation: AAI14621.1.
AB011140 mRNA. Translation: BAA25494.1.
CCDSiCCDS10526.1.
PIRiT00337.
RefSeqiNP_002696.3. NM_002705.4.
UniGeneiHs.192233.

Genome annotation databases

EnsembliENST00000345988; ENSP00000340510; ENSG00000118898.
GeneIDi5493.
KEGGihsa:5493.
UCSCiuc002cyd.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001691 mRNA. Translation: AAC17738.1.
AF013717 mRNA. Translation: AAC39668.1.
AF041004
, AF040999, AF041000, AF041002, AF041003 Genomic DNA. Translation: AAD17459.1.
AC027687 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85248.1.
BC114620 mRNA. Translation: AAI14621.1.
AB011140 mRNA. Translation: BAA25494.1.
CCDSiCCDS10526.1.
PIRiT00337.
RefSeqiNP_002696.3. NM_002705.4.
UniGeneiHs.192233.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4Q28X-ray2.64A/B/C/D1655-1756[»]
ProteinModelPortaliO60437.
SMRiO60437.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111488. 57 interactors.
IntActiO60437. 30 interactors.
MINTiMINT-1181651.
STRINGi9606.ENSP00000340510.

PTM databases

iPTMnetiO60437.
PhosphoSitePlusiO60437.
SwissPalmiO60437.

Polymorphism and mutation databases

BioMutaiPPL.

Proteomic databases

EPDiO60437.
MaxQBiO60437.
PaxDbiO60437.
PeptideAtlasiO60437.
PRIDEiO60437.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000345988; ENSP00000340510; ENSG00000118898.
GeneIDi5493.
KEGGihsa:5493.
UCSCiuc002cyd.1. human.

Organism-specific databases

CTDi5493.
DisGeNETi5493.
GeneCardsiPPL.
H-InvDBHIX0012794.
HGNCiHGNC:9273. PPL.
HPAiHPA042550.
HPA059859.
MIMi602871. gene.
neXtProtiNX_O60437.
OpenTargetsiENSG00000118898.
PharmGKBiPA33602.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQBN. Eukaryota.
ENOG410YHVZ. LUCA.
GeneTreeiENSGT00760000119163.
HOGENOMiHOG000168302.
HOVERGENiHBG053564.
InParanoidiO60437.
KOiK10386.
OMAiSYEPQET.
OrthoDBiEOG091G00CT.
PhylomeDBiO60437.
TreeFamiTF342779.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000118898-MONOMER.
ReactomeiR-HSA-6809371. Formation of the cornified envelope.

Miscellaneous databases

GeneWikiiPeriplakin.
GenomeRNAii5493.
PROiO60437.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000118898.
CleanExiHS_PPL.
ExpressionAtlasiO60437. baseline and differential.
GenevisibleiO60437. HS.

Family and domain databases

InterProiIPR001101. Plectin_repeat.
IPR018159. Spectrin/alpha-actinin.
[Graphical view]
SMARTiSM00250. PLEC. 2 hits.
SM00150. SPEC. 5 hits.
[Graphical view]
SUPFAMiSSF75399. SSF75399. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPEPL_HUMAN
AccessioniPrimary (citable) accession number: O60437
Secondary accession number(s): O60314, O60454, Q14C98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: January 11, 2011
Last modified: November 30, 2016
This is version 153 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.