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O60431

- OR1I1_HUMAN

UniProt

O60431 - OR1I1_HUMAN

Protein

Olfactory receptor 1I1

Gene

OR1I1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 1I1
    Alternative name(s):
    Olfactory receptor 19-20
    Short name:
    OR19-20
    Gene namesi
    Name:OR1I1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:8207. OR1I1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32078.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 355355Olfactory receptor 1I1PRO_0000150437Add
    BLAST

    Proteomic databases

    PaxDbiO60431.
    PRIDEiO60431.

    Expressioni

    Gene expression databases

    BgeeiO60431.
    CleanExiHS_OR1I1.
    GenevestigatoriO60431.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000209540.

    Structurei

    3D structure databases

    ProteinModelPortaliO60431.
    SMRiO60431. Positions 25-222.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini50 – 578CytoplasmicSequence Analysis
    Topological domaini80 – 10021ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini159 – 19537ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini220 – 23617CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini260 – 27213ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini293 – 35563CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4924Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei58 – 7922Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei101 – 12020Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei140 – 15819Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei196 – 21924Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei237 – 25923Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei273 – 29220Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG44361.
    HOGENOMiHOG000041364.
    HOVERGENiHBG017625.
    InParanoidiO60431.
    KOiK04257.
    OMAiYIRIFWT.
    OrthoDBiEOG71K63J.
    PhylomeDBiO60431.
    TreeFamiTF337210.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O60431-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPEKQTEIS EFFLQGLSEK PEHQTLLFTM FLSTYLVTII GNALIILAII    50
    TDSHLHTPMY FFLFNLSLVD TLLSSTTVPK MLANIQAQSR AIPFVGCLTQ 100
    MYAFHLFGTM DSFLLAVMAI DRFVAIVHPQ RYLVLMCSPV CGLLLGASWM 150
    ITNLQSLIHT CLMAQLTFCA GSEISHFFCD LMPLLKLSGS DTHTNELVIF 200
    AFGIVVGTSP FSCILLSYIR IFWTVFKIPS TRGKWKAFST CGLHLTVVSL 250
    SYGTIFAVYL QPTSPSSSQK DKAAALMCGV FIPMLNPFIY SIRNKDMKAA 300
    LGKLIGKVAV PCPRPEQLLD VYHVPGSLLA ARDTEMHPIP YPGGVQSLAG 350
    NRDME 355
    Length:355
    Mass (Da):39,297
    Last modified:August 1, 1998 - v1
    Checksum:i0C210102C186E413
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti50 – 501I → F.
    Corresponds to variant rs59166286 [ dbSNP | Ensembl ].
    VAR_062009
    Natural varianti139 – 1391P → R.
    Corresponds to variant rs8104843 [ dbSNP | Ensembl ].
    VAR_034164
    Natural varianti211 – 2111F → L.
    Corresponds to variant rs8108721 [ dbSNP | Ensembl ].
    VAR_034165
    Natural varianti252 – 2521Y → S.
    Corresponds to variant rs8105737 [ dbSNP | Ensembl ].
    VAR_034166
    Natural varianti292 – 2921I → T.
    Corresponds to variant rs16980312 [ dbSNP | Ensembl ].
    VAR_034167

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC004794 Genomic DNA. Translation: AAC18915.1.
    AF399548 Genomic DNA. Translation: AAK95033.1.
    CCDSiCCDS32937.1.
    RefSeqiNP_001004713.1. NM_001004713.1.
    UniGeneiHs.631610.

    Genome annotation databases

    EnsembliENST00000209540; ENSP00000209540; ENSG00000094661.
    GeneIDi126370.
    KEGGihsa:126370.
    UCSCiuc010xoe.2. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC004794 Genomic DNA. Translation: AAC18915.1 .
    AF399548 Genomic DNA. Translation: AAK95033.1 .
    CCDSi CCDS32937.1.
    RefSeqi NP_001004713.1. NM_001004713.1.
    UniGenei Hs.631610.

    3D structure databases

    ProteinModelPortali O60431.
    SMRi O60431. Positions 25-222.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000209540.

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PaxDbi O60431.
    PRIDEi O60431.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000209540 ; ENSP00000209540 ; ENSG00000094661 .
    GeneIDi 126370.
    KEGGi hsa:126370.
    UCSCi uc010xoe.2. human.

    Organism-specific databases

    CTDi 126370.
    GeneCardsi GC19P015197.
    H-InvDB HIX0202915.
    HGNCi HGNC:8207. OR1I1.
    neXtProti NX_O60431.
    PharmGKBi PA32078.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG44361.
    HOGENOMi HOG000041364.
    HOVERGENi HBG017625.
    InParanoidi O60431.
    KOi K04257.
    OMAi YIRIFWT.
    OrthoDBi EOG71K63J.
    PhylomeDBi O60431.
    TreeFami TF337210.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR1I1.
    GenomeRNAii 126370.
    NextBioi 81797.
    PROi O60431.

    Gene expression databases

    Bgeei O60431.
    CleanExi HS_OR1I1.
    Genevestigatori O60431.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.

    Entry informationi

    Entry nameiOR1I1_HUMAN
    AccessioniPrimary (citable) accession number: O60431
    Secondary accession number(s): Q96R92
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3