Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O60431 (OR1I1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 1I1
Alternative name(s):
Olfactory receptor 19-20
Short name=OR19-20
Gene names
Name:OR1I1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length355 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 355355Olfactory receptor 1I1
PRO_0000150437

Regions

Topological domain1 – 2525Extracellular Potential
Transmembrane26 – 4924Helical; Name=1; Potential
Topological domain50 – 578Cytoplasmic Potential
Transmembrane58 – 7922Helical; Name=2; Potential
Topological domain80 – 10021Extracellular Potential
Transmembrane101 – 12020Helical; Name=3; Potential
Topological domain121 – 13919Cytoplasmic Potential
Transmembrane140 – 15819Helical; Name=4; Potential
Topological domain159 – 19537Extracellular Potential
Transmembrane196 – 21924Helical; Name=5; Potential
Topological domain220 – 23617Cytoplasmic Potential
Transmembrane237 – 25923Helical; Name=6; Potential
Topological domain260 – 27213Extracellular Potential
Transmembrane273 – 29220Helical; Name=7; Potential
Topological domain293 – 35563Cytoplasmic Potential

Natural variations

Natural variant501I → F.
Corresponds to variant rs59166286 [ dbSNP | Ensembl ].
VAR_062009
Natural variant1391P → R.
Corresponds to variant rs8104843 [ dbSNP | Ensembl ].
VAR_034164
Natural variant2111F → L.
Corresponds to variant rs8108721 [ dbSNP | Ensembl ].
VAR_034165
Natural variant2521Y → S.
Corresponds to variant rs8105737 [ dbSNP | Ensembl ].
VAR_034166
Natural variant2921I → T.
Corresponds to variant rs16980312 [ dbSNP | Ensembl ].
VAR_034167

Sequences

Sequence LengthMass (Da)Tools
O60431 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 0C210102C186E413

FASTA35539,297
        10         20         30         40         50         60 
MEPEKQTEIS EFFLQGLSEK PEHQTLLFTM FLSTYLVTII GNALIILAII TDSHLHTPMY 

        70         80         90        100        110        120 
FFLFNLSLVD TLLSSTTVPK MLANIQAQSR AIPFVGCLTQ MYAFHLFGTM DSFLLAVMAI 

       130        140        150        160        170        180 
DRFVAIVHPQ RYLVLMCSPV CGLLLGASWM ITNLQSLIHT CLMAQLTFCA GSEISHFFCD 

       190        200        210        220        230        240 
LMPLLKLSGS DTHTNELVIF AFGIVVGTSP FSCILLSYIR IFWTVFKIPS TRGKWKAFST 

       250        260        270        280        290        300 
CGLHLTVVSL SYGTIFAVYL QPTSPSSSQK DKAAALMCGV FIPMLNPFIY SIRNKDMKAA 

       310        320        330        340        350 
LGKLIGKVAV PCPRPEQLLD VYHVPGSLLA ARDTEMHPIP YPGGVQSLAG NRDME 

« Hide

References

« Hide 'large scale' references
[1]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"DEFOG: a practical scheme for deciphering families of genes."
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R.
Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC004794 Genomic DNA. Translation: AAC18915.1.
AF399548 Genomic DNA. Translation: AAK95033.1.
CCDSCCDS32937.1.
RefSeqNP_001004713.1. NM_001004713.1.
UniGeneHs.631610.

3D structure databases

ProteinModelPortalO60431.
SMRO60431. Positions 25-222.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000209540.

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PaxDbO60431.
PRIDEO60431.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000209540; ENSP00000209540; ENSG00000094661.
GeneID126370.
KEGGhsa:126370.
UCSCuc010xoe.2. human.

Organism-specific databases

CTD126370.
GeneCardsGC19P015197.
H-InvDBHIX0202915.
HGNCHGNC:8207. OR1I1.
neXtProtNX_O60431.
PharmGKBPA32078.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG44361.
HOGENOMHOG000041364.
HOVERGENHBG017625.
InParanoidO60431.
KOK04257.
OMAYIRIFWT.
OrthoDBEOG71K63J.
PhylomeDBO60431.
TreeFamTF337210.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeO60431.
CleanExHS_OR1I1.
GenevestigatorO60431.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR1I1.
GenomeRNAi126370.
NextBio81797.
PROO60431.

Entry information

Entry nameOR1I1_HUMAN
AccessionPrimary (citable) accession number: O60431
Secondary accession number(s): Q96R92
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: August 1, 1998
Last modified: July 9, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries