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Protein

Olfactory receptor 1I1

Gene

OR1I1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000094661-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1I1
Alternative name(s):
Olfactory receptor 19-20
Short name:
OR19-20
Gene namesi
Name:OR1I1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:8207. OR1I1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 49Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 79Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 158Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini159 – 195ExtracellularSequence analysisAdd BLAST37
Transmembranei196 – 219Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini220 – 236CytoplasmicSequence analysisAdd BLAST17
Transmembranei237 – 259Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini260 – 272ExtracellularSequence analysisAdd BLAST13
Transmembranei273 – 292Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini293 – 355CytoplasmicSequence analysisAdd BLAST63

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000094661.
PharmGKBiPA32078.

Polymorphism and mutation databases

BioMutaiOR1I1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504371 – 355Olfactory receptor 1I1Add BLAST355

Proteomic databases

PaxDbiO60431.
PRIDEiO60431.

Expressioni

Gene expression databases

BgeeiENSG00000094661.
CleanExiHS_OR1I1.
GenevisibleiO60431. HS.

Organism-specific databases

HPAiCAB004236.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000209540.

Structurei

3D structure databases

ProteinModelPortaliO60431.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEC4. Eukaryota.
ENOG4111DX9. LUCA.
GeneTreeiENSGT00860000133676.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiO60431.
KOiK04257.
OMAiPCPRPEQ.
OrthoDBiEOG091G0B53.
PhylomeDBiO60431.
TreeFamiTF337210.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O60431-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPEKQTEIS EFFLQGLSEK PEHQTLLFTM FLSTYLVTII GNALIILAII
60 70 80 90 100
TDSHLHTPMY FFLFNLSLVD TLLSSTTVPK MLANIQAQSR AIPFVGCLTQ
110 120 130 140 150
MYAFHLFGTM DSFLLAVMAI DRFVAIVHPQ RYLVLMCSPV CGLLLGASWM
160 170 180 190 200
ITNLQSLIHT CLMAQLTFCA GSEISHFFCD LMPLLKLSGS DTHTNELVIF
210 220 230 240 250
AFGIVVGTSP FSCILLSYIR IFWTVFKIPS TRGKWKAFST CGLHLTVVSL
260 270 280 290 300
SYGTIFAVYL QPTSPSSSQK DKAAALMCGV FIPMLNPFIY SIRNKDMKAA
310 320 330 340 350
LGKLIGKVAV PCPRPEQLLD VYHVPGSLLA ARDTEMHPIP YPGGVQSLAG

NRDME
Length:355
Mass (Da):39,297
Last modified:August 1, 1998 - v1
Checksum:i0C210102C186E413
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06200950I → F.Corresponds to variant rs59166286dbSNPEnsembl.1
Natural variantiVAR_034164139P → R.Corresponds to variant rs8104843dbSNPEnsembl.1
Natural variantiVAR_034165211F → L.Corresponds to variant rs8108721dbSNPEnsembl.1
Natural variantiVAR_034166252Y → S.Corresponds to variant rs8105737dbSNPEnsembl.1
Natural variantiVAR_034167292I → T.Corresponds to variant rs16980312dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004794 Genomic DNA. Translation: AAC18915.1.
AF399548 Genomic DNA. Translation: AAK95033.1.
CCDSiCCDS32937.1.
RefSeqiNP_001004713.1. NM_001004713.1.
UniGeneiHs.631610.

Genome annotation databases

EnsembliENST00000209540; ENSP00000209540; ENSG00000094661.
GeneIDi126370.
KEGGihsa:126370.
UCSCiuc010xoe.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004794 Genomic DNA. Translation: AAC18915.1.
AF399548 Genomic DNA. Translation: AAK95033.1.
CCDSiCCDS32937.1.
RefSeqiNP_001004713.1. NM_001004713.1.
UniGeneiHs.631610.

3D structure databases

ProteinModelPortaliO60431.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000209540.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR1I1.

Proteomic databases

PaxDbiO60431.
PRIDEiO60431.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000209540; ENSP00000209540; ENSG00000094661.
GeneIDi126370.
KEGGihsa:126370.
UCSCiuc010xoe.3. human.

Organism-specific databases

CTDi126370.
GeneCardsiOR1I1.
H-InvDBHIX0202915.
HGNCiHGNC:8207. OR1I1.
HPAiCAB004236.
neXtProtiNX_O60431.
OpenTargetsiENSG00000094661.
PharmGKBiPA32078.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEC4. Eukaryota.
ENOG4111DX9. LUCA.
GeneTreeiENSGT00860000133676.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiO60431.
KOiK04257.
OMAiPCPRPEQ.
OrthoDBiEOG091G0B53.
PhylomeDBiO60431.
TreeFamiTF337210.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000094661-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR1I1.
GenomeRNAii126370.
PROiO60431.

Gene expression databases

BgeeiENSG00000094661.
CleanExiHS_OR1I1.
GenevisibleiO60431. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR1I1_HUMAN
AccessioniPrimary (citable) accession number: O60431
Secondary accession number(s): Q96R92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: August 1, 1998
Last modified: November 30, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.