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O60431

- OR1I1_HUMAN

UniProt

O60431 - OR1I1_HUMAN

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Protein

Olfactory receptor 1I1

Gene

OR1I1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1I1
Alternative name(s):
Olfactory receptor 19-20
Short name:
OR19-20
Gene namesi
Name:OR1I1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:8207. OR1I1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Transmembranei26 – 4924Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini50 – 578CytoplasmicSequence Analysis
Transmembranei58 – 7922Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini80 – 10021ExtracellularSequence AnalysisAdd
BLAST
Transmembranei101 – 12020Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei140 – 15819Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini159 – 19537ExtracellularSequence AnalysisAdd
BLAST
Transmembranei196 – 21924Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini220 – 23617CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei237 – 25923Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini260 – 27213ExtracellularSequence AnalysisAdd
BLAST
Transmembranei273 – 29220Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini293 – 35563CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32078.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 355355Olfactory receptor 1I1PRO_0000150437Add
BLAST

Proteomic databases

PaxDbiO60431.
PRIDEiO60431.

Expressioni

Gene expression databases

BgeeiO60431.
CleanExiHS_OR1I1.
GenevestigatoriO60431.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000209540.

Structurei

3D structure databases

ProteinModelPortaliO60431.
SMRiO60431. Positions 25-222.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG44361.
GeneTreeiENSGT00760000118845.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiO60431.
KOiK04257.
OMAiYIRIFWT.
OrthoDBiEOG71K63J.
PhylomeDBiO60431.
TreeFamiTF337210.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O60431-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEPEKQTEIS EFFLQGLSEK PEHQTLLFTM FLSTYLVTII GNALIILAII
60 70 80 90 100
TDSHLHTPMY FFLFNLSLVD TLLSSTTVPK MLANIQAQSR AIPFVGCLTQ
110 120 130 140 150
MYAFHLFGTM DSFLLAVMAI DRFVAIVHPQ RYLVLMCSPV CGLLLGASWM
160 170 180 190 200
ITNLQSLIHT CLMAQLTFCA GSEISHFFCD LMPLLKLSGS DTHTNELVIF
210 220 230 240 250
AFGIVVGTSP FSCILLSYIR IFWTVFKIPS TRGKWKAFST CGLHLTVVSL
260 270 280 290 300
SYGTIFAVYL QPTSPSSSQK DKAAALMCGV FIPMLNPFIY SIRNKDMKAA
310 320 330 340 350
LGKLIGKVAV PCPRPEQLLD VYHVPGSLLA ARDTEMHPIP YPGGVQSLAG

NRDME
Length:355
Mass (Da):39,297
Last modified:August 1, 1998 - v1
Checksum:i0C210102C186E413
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti50 – 501I → F.
Corresponds to variant rs59166286 [ dbSNP | Ensembl ].
VAR_062009
Natural varianti139 – 1391P → R.
Corresponds to variant rs8104843 [ dbSNP | Ensembl ].
VAR_034164
Natural varianti211 – 2111F → L.
Corresponds to variant rs8108721 [ dbSNP | Ensembl ].
VAR_034165
Natural varianti252 – 2521Y → S.
Corresponds to variant rs8105737 [ dbSNP | Ensembl ].
VAR_034166
Natural varianti292 – 2921I → T.
Corresponds to variant rs16980312 [ dbSNP | Ensembl ].
VAR_034167

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004794 Genomic DNA. Translation: AAC18915.1.
AF399548 Genomic DNA. Translation: AAK95033.1.
CCDSiCCDS32937.1.
RefSeqiNP_001004713.1. NM_001004713.1.
UniGeneiHs.631610.

Genome annotation databases

EnsembliENST00000209540; ENSP00000209540; ENSG00000094661.
GeneIDi126370.
KEGGihsa:126370.
UCSCiuc010xoe.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004794 Genomic DNA. Translation: AAC18915.1 .
AF399548 Genomic DNA. Translation: AAK95033.1 .
CCDSi CCDS32937.1.
RefSeqi NP_001004713.1. NM_001004713.1.
UniGenei Hs.631610.

3D structure databases

ProteinModelPortali O60431.
SMRi O60431. Positions 25-222.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000209540.

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PaxDbi O60431.
PRIDEi O60431.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000209540 ; ENSP00000209540 ; ENSG00000094661 .
GeneIDi 126370.
KEGGi hsa:126370.
UCSCi uc010xoe.2. human.

Organism-specific databases

CTDi 126370.
GeneCardsi GC19P015197.
H-InvDB HIX0202915.
HGNCi HGNC:8207. OR1I1.
neXtProti NX_O60431.
PharmGKBi PA32078.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG44361.
GeneTreei ENSGT00760000118845.
HOGENOMi HOG000041364.
HOVERGENi HBG017625.
InParanoidi O60431.
KOi K04257.
OMAi YIRIFWT.
OrthoDBi EOG71K63J.
PhylomeDBi O60431.
TreeFami TF337210.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR1I1.
GenomeRNAii 126370.
NextBioi 81797.
PROi O60431.

Gene expression databases

Bgeei O60431.
CleanExi HS_OR1I1.
Genevestigatori O60431.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.

Entry informationi

Entry nameiOR1I1_HUMAN
AccessioniPrimary (citable) accession number: O60431
Secondary accession number(s): Q96R92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: August 1, 1998
Last modified: October 29, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3