O60431 (OR1I1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 1I1

Alternative name(s):
Olfactory receptor 19-20
Short name=OR19-20

Gene names

Name:

OR1I1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	355 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 355	355	Olfactory receptor 1I1		PRO_0000150437
Regions
	Topological domain	1 – 25	25	Extracellular Potential
	Transmembrane	26 – 49	24	Helical; Name=1; Potential
	Topological domain	50 – 57	8	Cytoplasmic Potential
	Transmembrane	58 – 79	22	Helical; Name=2; Potential
	Topological domain	80 – 100	21	Extracellular Potential
	Transmembrane	101 – 120	20	Helical; Name=3; Potential
	Topological domain	121 – 139	19	Cytoplasmic Potential
	Transmembrane	140 – 158	19	Helical; Name=4; Potential
	Topological domain	159 – 195	37	Extracellular Potential
	Transmembrane	196 – 219	24	Helical; Name=5; Potential
	Topological domain	220 – 236	17	Cytoplasmic Potential
	Transmembrane	237 – 259	23	Helical; Name=6; Potential
	Topological domain	260 – 272	13	Extracellular Potential
	Transmembrane	273 – 292	20	Helical; Name=7; Potential
	Topological domain	293 – 355	63	Cytoplasmic Potential
Natural variations
	Natural variant	50	1	I → F. Corresponds to variant rs59166286 [ dbSNP | Ensembl ].		VAR_062009
	Natural variant	139	1	P → R. Corresponds to variant rs8104843 [ dbSNP | Ensembl ].		VAR_034164
	Natural variant	211	1	F → L. Corresponds to variant rs8108721 [ dbSNP | Ensembl ].		VAR_034165
	Natural variant	252	1	Y → S. Corresponds to variant rs8105737 [ dbSNP | Ensembl ].		VAR_034166
	Natural variant	292	1	I → T. Corresponds to variant rs16980312 [ dbSNP | Ensembl ].		VAR_034167

Sequences

	Sequence		Length	Mass (Da)
	O60431 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 0C210102C186E413	FASTA	355	39,297
	10 20 30 40 50 60 MEPEKQTEIS EFFLQGLSEK PEHQTLLFTM FLSTYLVTII GNALIILAII TDSHLHTPMY 70 80 90 100 110 120 FFLFNLSLVD TLLSSTTVPK MLANIQAQSR AIPFVGCLTQ MYAFHLFGTM DSFLLAVMAI 130 140 150 160 170 180 DRFVAIVHPQ RYLVLMCSPV CGLLLGASWM ITNLQSLIHT CLMAQLTFCA GSEISHFFCD 190 200 210 220 230 240 LMPLLKLSGS DTHTNELVIF AFGIVVGTSP FSCILLSYIR IFWTVFKIPS TRGKWKAFST 250 260 270 280 290 300 CGLHLTVVSL SYGTIFAVYL QPTSPSSSQK DKAAALMCGV FIPMLNPFIY SIRNKDMKAA 310 320 330 340 350 LGKLIGKVAV PCPRPEQLLD VYHVPGSLLA ARDTEMHPIP YPGGVQSLAG NRDME

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"DEFOG: a practical scheme for deciphering families of genes." Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R. Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC004794 Genomic DNA. Translation: AAC18915.1. AF399548 Genomic DNA. Translation: AAK95033.1.
IPI	IPI00029620.
RefSeq	NP_001004713.1. NM_001004713.1.
UniGene	Hs.631610.
3D structure databases
ProteinModelPortal	O60431.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000209540.
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PaxDb	O60431.
PRIDE	O60431.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000209540; ENSP00000209540; ENSG00000094661.
GeneID	126370.
KEGG	hsa:126370.
UCSC	uc010xoe.2. human.
Organism-specific databases
CTD	126370.
GeneCards	GC19P015197.
H-InvDB	HIX0202915.
HGNC	HGNC:8207. OR1I1.
neXtProt	NX_O60431.
PharmGKB	PA32078.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG44361.
HOGENOM	HOG000041364.
HOVERGEN	HBG017625.
InParanoid	O60431.
KO	K04257.
OMA	LQSLIHT.
OrthoDB	EOG4N04FB.
PhylomeDB	O60431.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
Bgee	O60431.
CleanEx	HS_OR1I1.
Genevestigator	O60431.
GermOnline	ENSG00000094661. Homo sapiens.
Family and domain databases
InterPro	IPR019424. 7TM_GPCR_olfarory/Srsx. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PANTHER	PTHR24236. PTHR24236. 1 hit.
Pfam	PF10320. 7TM_GPCR_Srsx. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	126370.
NextBio	81797.

Entry information

Entry name

OR1I1_HUMAN

Accession

Primary (citable) accession number: O60431
Secondary accession number(s): Q96R92

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	August 1, 1998
Last modified:	May 1, 2013
This is version 106 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.