Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O60423

- AT8B3_HUMAN

UniProt

O60423 - AT8B3_HUMAN

Protein

Phospholipid-transporting ATPase IK

Gene

ATP8B3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 137 (01 Oct 2014)
      Sequence version 4 (05 Oct 2010)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    P4-ATPase flippase which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. May be responsible for the maintenance of asymmetric distribution of phosphatidylserine (PS) in spermatozoa membranes. Involved in acrosome reactions and binding of spermatozoa to zona pellucida By similarity.By similarity

    Catalytic activityi

    ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei495 – 49514-aspartylphosphate intermediateBy similarity
    Metal bindingi939 – 9391MagnesiumBy similarity
    Metal bindingi943 – 9431MagnesiumBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cation-transporting ATPase activity Source: InterPro
    3. magnesium ion binding Source: InterPro
    4. phospholipid-translocating ATPase activity Source: UniProtKB-EC

    GO - Biological processi

    1. binding of sperm to zona pellucida Source: Ensembl

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid transport, Transport

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_25149. Ion transport by P-type ATPases.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phospholipid-transporting ATPase IK (EC:3.6.3.1)
    Alternative name(s):
    ATPase class I type 8B member 3
    Gene namesi
    Name:ATP8B3
    Synonyms:ATP1K, FOS37502_2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:13535. ATP8B3.

    Subcellular locationi

    Cytoplasmic vesiclesecretory vesicleacrosome membrane By similarity; Multi-pass membrane protein By similarity. Endoplasmic reticulum 1 Publication

    GO - Cellular componenti

    1. acrosomal membrane Source: UniProtKB-SubCell
    2. endoplasmic reticulum Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25168.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13001300Phospholipid-transporting ATPase IKPRO_0000046367Add
    BLAST

    Proteomic databases

    PaxDbiO60423.
    PRIDEiO60423.

    PTM databases

    PhosphoSiteiO60423.

    Expressioni

    Tissue specificityi

    Isoform 3 was only detected in testis.1 Publication

    Gene expression databases

    ArrayExpressiO60423.
    BgeeiO60423.
    CleanExiHS_ATP8B3.
    GenevestigatoriO60423.

    Organism-specific databases

    HPAiHPA041992.
    HPA043582.

    Interactioni

    Protein-protein interaction databases

    BioGridi127132. 1 interaction.
    MINTiMINT-4656966.
    STRINGi9606.ENSP00000311336.

    Structurei

    3D structure databases

    ProteinModelPortaliO60423.
    SMRiO60423. Positions 740-779, 912-974.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 149149CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini172 – 1776Exoplasmic loopSequence Analysis
    Topological domaini198 – 381184CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini404 – 43027Exoplasmic loopSequence AnalysisAdd
    BLAST
    Topological domaini453 – 995543CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1017 – 102812Exoplasmic loopSequence AnalysisAdd
    BLAST
    Topological domaini1049 – 107830CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1101 – 111212Exoplasmic loopSequence AnalysisAdd
    BLAST
    Topological domaini1136 – 11416CytoplasmicSequence Analysis
    Topological domaini1163 – 118220Exoplasmic loopSequence AnalysisAdd
    BLAST
    Topological domaini1208 – 130093CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei150 – 17122HelicalSequence AnalysisAdd
    BLAST
    Transmembranei178 – 19720HelicalSequence AnalysisAdd
    BLAST
    Transmembranei382 – 40322HelicalSequence AnalysisAdd
    BLAST
    Transmembranei431 – 45222HelicalSequence AnalysisAdd
    BLAST
    Transmembranei996 – 101621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1029 – 104820HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1079 – 110022HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1113 – 113523HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1142 – 116221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1183 – 120725HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0474.
    HOGENOMiHOG000202528.
    HOVERGENiHBG050601.
    InParanoidiO60423.
    KOiK01530.
    OMAiKENPYLW.
    OrthoDBiEOG7RRF68.
    PhylomeDBiO60423.
    TreeFamiTF300654.

    Family and domain databases

    Gene3Di2.70.150.10. 2 hits.
    3.40.1110.10. 1 hit.
    3.40.50.1000. 2 hits.
    InterProiIPR023299. ATPase_P-typ_cyto_domN.
    IPR018303. ATPase_P-typ_P_site.
    IPR006539. ATPase_P-typ_Plipid-transp.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view]
    PANTHERiPTHR24092. PTHR24092. 1 hit.
    PfamiPF00122. E1-E2_ATPase. 1 hit.
    [Graphical view]
    PRINTSiPR00119. CATATPASE.
    SUPFAMiSSF56784. SSF56784. 3 hits.
    SSF81660. SSF81660. 2 hits.
    TIGRFAMsiTIGR01652. ATPase-Plipid. 1 hit.
    TIGR01494. ATPase_P-type. 1 hit.
    PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O60423-2) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGTGPAQTPR STRAGPEPSP APPGPGDTGD SDVTQEGSGP AGIRGGETVI     50
    RAGMGDSPGR GAPERRHKAQ PGRARKYEWR PEGPTSMGSL GQREDLQDED 100
    RNSAFTWKVQ ANNRAYNGQF KEKVILCWQR KKYKTNVIRT AKYNFYSFLP 150
    LNLYEQFHRV SNLFFLIIII LQSIPDISTL PWFSLSTPMV CLLFIRATRD 200
    LVDDMGRHKS DRAINNRPCQ ILMGKSFKQK KWQDLCVGDV VCLRKDNIVP 250
    ADMLLLASTE PSSLCYVETV DIDGETNLKF RQALMVTHKE LATIKKMASF 300
    QGTVTCEAPN SRMHHFVGCL EWNDKKYSLD IGNLLLRGCR IRNTDTCYGL 350
    VIYAGFDTKI MKNCGKIHLK RTKLDLLMNK LVVVIFISVV LVCLVLAFGF 400
    GFSVKEFKDH HYYLSGVHGS SVAAESFFVF WSFLILLSVT IPMSMFILSE 450
    FIYLGNSVFI DWDVQMYYKP QDVPAKARST SLNDHLGQVE YIFSDKTGTL 500
    TQNILTFNKC CISGRVYGPD SEATTRPKEN PYLWNKFADG KLLFHNAALL 550
    HLVRTNGDEA VREFWRLLAI CHTVMVRESP RERPDQLLYQ AASPDEGALV 600
    TAARNFGYVF LSRTQDTVTI MELGEERVYQ VLAIMDFNST RKRMSVLVRK 650
    PEGAICLYTK GADTVIFERL HRRGAMEFAT EEALAAFAQE TLRTLCLAYR 700
    EVAEDIYEDW QQRHQEASLL LQNRAQALQQ LLGATAIEDR LQDGVPETIK 750
    CLKKSNIKIW VLTGDKQETA VNIGFACELL SENMLILEEK EISRILETYW 800
    ENSNNLLTRE SLSQVKLALV INGDFLDKLL VSLRKEPRAL AQNVNMDEAW 850
    QELGQSRRDF LYARRLSLLC RRFGLPLAAP PAQDSRARRS SEVLQERAFV 900
    DLASKCQAVI CCRVTPKQKA LIVALVKKYH QVVTLAIGDG ANDINMIKTA 950
    DVGVGLAGQE GMQAVQNSDF VLGQFCFLQR LLLVHGRWSY VRICKFLRYF 1000
    FYKSMASMMV QVWFACYNGF TGQPLYEGWF LALFNLLYST LPVLYIGLFE 1050
    QDVSAEQSLE KPELYVVGQK DELFNYWVFV QAIAHGVTTS LVNFFMTLWI 1100
    SRDTAGPASF SDHQSFAVVV ALSCLLSITM EVILIIKYWT ALCVATILLS 1150
    LGFYAIMTTT TQSFWLFRVS PTTFPFLYAD LSVMSSPSIL LVVLLSVSIN 1200
    TFPVLALRVI FPALKELRAK EEKVEEGPSE EIFTMEPLPH VHRESRARRS 1250
    SYAFSHREGY ANLITQGTIL RRGPGVSSDI ASESLDPSDE EAASSPKESQ 1300
    Length:1,300
    Mass (Da):146,752
    Last modified:October 5, 2010 - v4
    Checksum:i356B1972DD49DFF5
    GO
    Isoform 2 (identifier: O60423-1) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         730-730: Q → QVYNEMEQDLR

    Note: No experimental confirmation available.

    Show »
    Length:1,310
    Mass (Da):148,031
    Checksum:iF1A1C25A8DE696FC
    GO
    Isoform 3 (identifier: O60423-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-53: Missing.
         354-354: A → ADGYMFV
         730-730: Q → QVYNEMEQDLR

    Note: No experimental confirmation available.

    Show »
    Length:1,263
    Mass (Da):143,705
    Checksum:i246752DB1DAC2E44
    GO

    Sequence cautioni

    The sequence BAB71492.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAC17601.1 differs from that shown. Reason: Erroneous gene model prediction.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti45 – 451G → R.
    Corresponds to variant rs7250872 [ dbSNP | Ensembl ].
    VAR_055544
    Natural varianti618 – 6181V → I.
    Corresponds to variant rs8100856 [ dbSNP | Ensembl ].
    VAR_055545

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 5353Missing in isoform 3. 1 PublicationVSP_043554Add
    BLAST
    Alternative sequencei354 – 3541A → ADGYMFV in isoform 3. 1 PublicationVSP_043555
    Alternative sequencei730 – 7301Q → QVYNEMEQDLR in isoform 2 and isoform 3. 1 PublicationVSP_039716

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY302538 mRNA. Translation: AAQ19028.1.
    AC004755 Genomic DNA. Translation: AAC17601.1. Sequence problems.
    AC012615 Genomic DNA. No translation available.
    CH471139 Genomic DNA. Translation: EAW69455.1.
    AK057452 mRNA. Translation: BAB71492.1. Different initiation.
    BC035162 mRNA. Translation: AAH35162.3.
    CCDSiCCDS45901.1. [O60423-2]
    CCDS54196.1. [O60423-3]
    RefSeqiNP_001171473.1. NM_001178002.2. [O60423-3]
    NP_620168.1. NM_138813.3. [O60423-2]
    XP_006722717.1. XM_006722654.1. [O60423-1]
    XP_006722718.1. XM_006722655.1. [O60423-1]
    UniGeneiHs.306212.

    Genome annotation databases

    EnsembliENST00000310127; ENSP00000311336; ENSG00000130270. [O60423-2]
    ENST00000525591; ENSP00000437115; ENSG00000130270. [O60423-3]
    GeneIDi148229.
    KEGGihsa:148229.
    UCSCiuc002ltv.4. human. [O60423-3]
    uc002ltw.4. human. [O60423-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY302538 mRNA. Translation: AAQ19028.1 .
    AC004755 Genomic DNA. Translation: AAC17601.1 . Sequence problems.
    AC012615 Genomic DNA. No translation available.
    CH471139 Genomic DNA. Translation: EAW69455.1 .
    AK057452 mRNA. Translation: BAB71492.1 . Different initiation.
    BC035162 mRNA. Translation: AAH35162.3 .
    CCDSi CCDS45901.1. [O60423-2 ]
    CCDS54196.1. [O60423-3 ]
    RefSeqi NP_001171473.1. NM_001178002.2. [O60423-3 ]
    NP_620168.1. NM_138813.3. [O60423-2 ]
    XP_006722717.1. XM_006722654.1. [O60423-1 ]
    XP_006722718.1. XM_006722655.1. [O60423-1 ]
    UniGenei Hs.306212.

    3D structure databases

    ProteinModelPortali O60423.
    SMRi O60423. Positions 740-779, 912-974.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127132. 1 interaction.
    MINTi MINT-4656966.
    STRINGi 9606.ENSP00000311336.

    PTM databases

    PhosphoSitei O60423.

    Proteomic databases

    PaxDbi O60423.
    PRIDEi O60423.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000310127 ; ENSP00000311336 ; ENSG00000130270 . [O60423-2 ]
    ENST00000525591 ; ENSP00000437115 ; ENSG00000130270 . [O60423-3 ]
    GeneIDi 148229.
    KEGGi hsa:148229.
    UCSCi uc002ltv.4. human. [O60423-3 ]
    uc002ltw.4. human. [O60423-2 ]

    Organism-specific databases

    CTDi 148229.
    GeneCardsi GC19M001733.
    H-InvDB HIX0202756.
    HGNCi HGNC:13535. ATP8B3.
    HPAi HPA041992.
    HPA043582.
    MIMi 605866. gene.
    neXtProti NX_O60423.
    PharmGKBi PA25168.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0474.
    HOGENOMi HOG000202528.
    HOVERGENi HBG050601.
    InParanoidi O60423.
    KOi K01530.
    OMAi KENPYLW.
    OrthoDBi EOG7RRF68.
    PhylomeDBi O60423.
    TreeFami TF300654.

    Enzyme and pathway databases

    Reactomei REACT_25149. Ion transport by P-type ATPases.

    Miscellaneous databases

    ChiTaRSi ATP8B3. human.
    GeneWikii ATP8B3.
    GenomeRNAii 148229.
    NextBioi 85875.
    PROi O60423.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O60423.
    Bgeei O60423.
    CleanExi HS_ATP8B3.
    Genevestigatori O60423.

    Family and domain databases

    Gene3Di 2.70.150.10. 2 hits.
    3.40.1110.10. 1 hit.
    3.40.50.1000. 2 hits.
    InterProi IPR023299. ATPase_P-typ_cyto_domN.
    IPR018303. ATPase_P-typ_P_site.
    IPR006539. ATPase_P-typ_Plipid-transp.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view ]
    PANTHERi PTHR24092. PTHR24092. 1 hit.
    Pfami PF00122. E1-E2_ATPase. 1 hit.
    [Graphical view ]
    PRINTSi PR00119. CATATPASE.
    SUPFAMi SSF56784. SSF56784. 3 hits.
    SSF81660. SSF81660. 2 hits.
    TIGRFAMsi TIGR01652. ATPase-Plipid. 1 hit.
    TIGR01494. ATPase_P-type. 1 hit.
    PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "FIC1, a P-type ATPase linked to cholestatic liver disease, has homologues (ATP8B2 and ATP8B3) expressed throughout the body."
      Harris M.J., Arias I.M.
      Biochim. Biophys. Acta 1633:127-131(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY.
    2. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Eye and Testis.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 968-1300.
      Tissue: Testis.
    6. "Heteromeric interactions required for abundance and subcellular localization of human CDC50 proteins and class 1 P4-ATPases."
      van der Velden L.M., Wichers C.G., van Breevoort A.E., Coleman J.A., Molday R.S., Berger R., Klomp L.W., van de Graaf S.F.
      J. Biol. Chem. 285:40088-40096(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiAT8B3_HUMAN
    AccessioniPrimary (citable) accession number: O60423
    Secondary accession number(s): Q7Z485
    , Q8IVB8, Q8N4Y8, Q96M22
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 137 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Association with flippase complex beta subunits TMEM30A and TMEM30A has not been detected, neither did their coexpression change the localization in ER.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3