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Reviewed, UniProtKB/Swiss-Prot O60423 (AT8B3_HUMAN)

Last modified November 3, 2009. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Probable phospholipid-transporting ATPase IK
    EC=3.6.3.1
Alternative name(s):
    ATPase class I type 8B member 3
Gene names
Name: ATP8B3
Synonyms: ATP1K, FOS37502_2
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1310 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Catalytic activity

ATP + H2O + phospholipid(In) = ADP + phosphate + phospholipid(Out).

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cation transport ATPase (P-type) family. Type IV subfamily.

Sequence caution

The sequence AAC17601.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O60423-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform 2 (identifier: O60423-2)

The sequence of this isoform differs from the canonical sequence as follows:
     731-740: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13101310Probable phospholipid-transporting ATPase IK
PRO_0000046367

Regions

Topological domain1 – 149149Cytoplasmic Potential
Transmembrane150 – 17122 Potential
Topological domain172 – 1776Extracellular Potential
Transmembrane178 – 19720 Potential
Topological domain198 – 381184Cytoplasmic Potential
Transmembrane382 – 40322 Potential
Topological domain404 – 43027Extracellular Potential
Transmembrane431 – 45222 Potential
Topological domain453 – 1005553Cytoplasmic Potential
Transmembrane1006 – 102621 Potential
Topological domain1027 – 103812Extracellular Potential
Transmembrane1039 – 105820 Potential
Topological domain1059 – 108830Cytoplasmic Potential
Transmembrane1089 – 111022 Potential
Topological domain1111 – 112212Extracellular Potential
Transmembrane1123 – 114523 Potential
Topological domain1146 – 11516Cytoplasmic Potential
Transmembrane1152 – 117221 Potential
Topological domain1173 – 119220Extracellular Potential
Transmembrane1193 – 121725 Potential
Topological domain1218 – 131093Cytoplasmic Potential

Sites

Active site49514-aspartylphosphate intermediate By similarity
Metal binding9491Magnesium By similarity
Metal binding9531Magnesium By similarity

Natural variations

Alternative sequence731 – 74010Missing in isoform 2.
VSP_007304
Natural variant451G → R: dbSNP rs7250872.
VAR_055544
Natural variant6181V → I: dbSNP rs8100856.
VAR_055545

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 30, 2003. Version 3.
Checksum: F1A1C25A8DE696FC

FASTA1,310148,031
        10         20         30         40         50         60 
MGTGPAQTPR STRAGPEPSP APPGPGDTGD SDVTQEGSGP AGIRGGETVI RAGMGDSPGR 

        70         80         90        100        110        120 
GAPERRHKAQ PGRARKYEWR PEGPTSMGSL GQREDLQDED RNSAFTWKVQ ANNRAYNGQF 

       130        140        150        160        170        180 
KEKVILCWQR KKYKTNVIRT AKYNFYSFLP LNLYEQFHRV SNLFFLIIII LQSIPDISTL 

       190        200        210        220        230        240 
PWFSLSTPMV CLLFIRATRD LVDDMGRHKS DRAINNRPCQ ILMGKSFKQK KWQDLCVGDV 

       250        260        270        280        290        300 
VCLRKDNIVP ADMLLLASTE PSSLCYVETV DIDGETNLKF RQALMVTHKE LATIKKMASF 

       310        320        330        340        350        360 
QGTVTCEAPN SRMHHFVGCL EWNDKKYSLD IGNLLLRGCR IRNTDTCYGL VIYAGFDTKI 

       370        380        390        400        410        420 
MKNCGKIHLK RTKLDLLMNK LVVVIFISVV LVCLVLAFGF GFSVKEFKDH HYYLSGVHGS 

       430        440        450        460        470        480 
SVAAESFFVF WSFLILLSVT IPMSMFILSE FIYLGNSVFI DWDVQMYYKP QDVPAKARST 

       490        500        510        520        530        540 
SLNDHLGQVE YIFSDKTGTL TQNILTFNKC CISGRVYGPD SEATTRPKEN PYLWNKFADG 

       550        560        570        580        590        600 
KLLFHNAALL HLVRTNGDEA VREFWRLLAI CHTVMVRESP RERPDQLLYQ AASPDEGALV 

       610        620        630        640        650        660 
TAARNFGYVF LSRTQDTVTI MELGEERVYQ VLAIMDFNST RKRMSVLVRK PEGAICLYTK 

       670        680        690        700        710        720 
GADTVIFERL HRRGAMEFAT EEALAAFAQE TLRTLCLAYR EVAEDIYEDW QQRHQEASLL 

       730        740        750        760        770        780 
LQNRAQALQQ VYNEMEQDLR LLGATAIEDR LQDGVPETIK CLKKSNIKIW VLTGDKQETA 

       790        800        810        820        830        840 
VNIGFACELL SENMLILEEK EISRILETYW ENSNNLLTRE SLSQVKLALV INGDFLDKLL 

       850        860        870        880        890        900 
VSLRKEPRAL AQNVNMDEAW QELGQSRRDF LYARRLSLLC RRFGLPLAAP PAQDSRARRS 

       910        920        930        940        950        960 
SEVLQERAFV DLASKCQAVI CCRVTPKQKA LIVALVKKYH QVVTLAIGDG ANDINMIKTA 

       970        980        990       1000       1010       1020 
DVGVGLAGQE GMQAVQNSDF VLGQFCFLQR LLLVHGRWSY VRICKFLRYF FYKSMASMMV 

      1030       1040       1050       1060       1070       1080 
QVWFACYNGF TGQPLYEGWF LALFNLLYST LPVLYIGLFE QDVSAEQSLE KPELYVVGQK 

      1090       1100       1110       1120       1130       1140 
DELFNYWVFV QAIAHGVTTS LVNFFMTLWI SRDTAGPASF SDHQSFAVVV ALSCLLSITM 

      1150       1160       1170       1180       1190       1200 
EVILIIKYWT ALCVATILLS LGFYAIMTTT TQSFWLFRVS PTTFPFLYAD LSVMSSPSIL 

      1210       1220       1230       1240       1250       1260 
LVVLLSVSIN TFPVLALRVI FPALKELRAK EEKVEEGPSE EIFTMEPLPH VHRESRARRS 

      1270       1280       1290       1300       1310 
SYAFSHREGY ANLITQGTIL RRGPGVSSDI ASESLDPSDE EAASSPKESQ 

« Hide

Isoform 2.

Checksum: 356B1972DD49DFF5
Show »

FASTA1,300146,752

References

[1]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed: 15057824] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Eye and Testis.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 978-1310.
Tissue: Testis.

Cross-references

Sequence databases

AC004755 Genomic DNA. Translation: AAC17601.1. Sequence problems.
AC012615 Genomic DNA. No translation available.
AK057452 mRNA. Translation: BAB71492.1. Different initiation.
BC035162 mRNA. Translation: AAH35162.3.
IPIIPI00216974.
IPI00237913.
RefSeqNP_620168.1.
UniGeneHs.306212

3D structure databases

ModBaseSearch...

PTM databases

PhosphoSiteO60423.

Proteomic databases

PRIDEO60423.

Genome annotation databases

EnsemblENST00000310127; ENSP00000311336; ENSG00000130270; Homo sapiens. [Genome view]
ENST00000382339; ENSP00000371776; ENSG00000130270; Homo sapiens. [Genome view]
GeneID148229.
KEGGhsa:148229.
UCSCuc002ltw.1. human.

Organism-specific databases

CTD148229.
GeneCardsGC19M001733.
HGNCHGNC:13535. ATP8B3.
MIM605866. gene.
PharmGKBPA25168.
GenAtlasSearch...

Phylogenomic databases

HOGENOMO60423.
HOVERGENO60423.
OMARVYQVLA.

Enzyme and pathway databases

BRENDA3.6.3.1. 247.

Gene expression databases

ArrayExpressO60423.
BgeeO60423.
CleanExHS_ATP8B3.
GenevestigatorO60423.
GermOnlineENSG00000130270. Homo sapiens.

Family and domain databases

InterProIPR008250. ATPase_P-typ_ATPase-assoc-reg.
IPR001757. ATPase_P-typ_ion-transptr.
IPR018303. ATPase_P-typ_P_site.
IPR006539. ATPase_P-typ_Plipid-transl.
IPR013200. HAD-SF_hydro-like_3.
[Graphical view]
PANTHERPTHR11939. ATPase_P. 1 hit.
PfamPF00122. E1-E2_ATPase. 1 hit.
PF08282. Hydrolase_3. 1 hit.
[Graphical view]
PRINTSPR00119. CATATPASE.
TIGRFAMsTIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio85875.
SOURCESearch...

Entry information

Entry nameAT8B3_HUMAN
AccessionPrimary (citable) accession number: O60423
Secondary accession number(s): Q8IVB8, Q8N4Y8, Q96M22
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 30, 2003
Last modified: November 3, 2009
This is version 89 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents