O60423 (AT8B3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable phospholipid-transporting ATPase IK
EC=3.6.3.1

Alternative name(s):
ATPase class I type 8B member 3

Gene names

Name:	ATP8B3
Synonyms:	ATP1K, FOS37502_2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1300 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + H2O + phospholipid(side 1) = ADP + phosphate + phospholipid(side 2).
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Isoform 3 was only detected in testis. Ref.1
Sequence similarities	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. [View classification]
Sequence caution	The sequence AAC17601.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence BAB71492.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	binding of sperm to zona pellucida Inferred from electronic annotation. Source: Compara phospholipid translocation Inferred from electronic annotation. Source: Compara
Cellular_component	acrosomal vesicle Inferred from electronic annotation. Source: Compara integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cation-transporting ATPase activity Inferred from electronic annotation. Source: InterPro magnesium ion binding Inferred from electronic annotation. Source: InterPro phospholipid-translocating ATPase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O60423-2)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O60423-1)

The sequence of this isoform differs from the canonical sequence as follows:
     730-730: Q → QVYNEMEQDLR

Note: No experimental confirmation available.

Isoform 3 (identifier: O60423-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: Missing.
     354-354: A → ADGYMFV
     730-730: Q → QVYNEMEQDLR

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1300	1300	Probable phospholipid-transporting ATPase IK		PRO_0000046367
Regions
	Topological domain	1 – 149	149	Cytoplasmic Potential
	Transmembrane	150 – 171	22	Helical; Potential
	Topological domain	172 – 177	6	Extracellular Potential
	Transmembrane	178 – 197	20	Helical; Potential
	Topological domain	198 – 381	184	Cytoplasmic Potential
	Transmembrane	382 – 403	22	Helical; Potential
	Topological domain	404 – 430	27	Extracellular Potential
	Transmembrane	431 – 452	22	Helical; Potential
	Topological domain	453 – 995	543	Cytoplasmic Potential
	Transmembrane	996 – 1016	21	Helical; Potential
	Topological domain	1017 – 1028	12	Extracellular Potential
	Transmembrane	1029 – 1048	20	Helical; Potential
	Topological domain	1049 – 1078	30	Cytoplasmic Potential
	Transmembrane	1079 – 1100	22	Helical; Potential
	Topological domain	1101 – 1112	12	Extracellular Potential
	Transmembrane	1113 – 1135	23	Helical; Potential
	Topological domain	1136 – 1141	6	Cytoplasmic Potential
	Transmembrane	1142 – 1162	21	Helical; Potential
	Topological domain	1163 – 1182	20	Extracellular Potential
	Transmembrane	1183 – 1207	25	Helical; Potential
	Topological domain	1208 – 1300	93	Cytoplasmic Potential
Sites
	Active site	495	1	4-aspartylphosphate intermediate By similarity
	Metal binding	939	1	Magnesium By similarity
	Metal binding	943	1	Magnesium By similarity
Natural variations
	Alternative sequence	1 – 53	53	Missing in isoform 3.		VSP_043554
	Alternative sequence	354	1	A → ADGYMFV in isoform 3.		VSP_043555
	Alternative sequence	730	1	Q → QVYNEMEQDLR in isoform 2 and isoform 3.		VSP_039716
	Natural variant	45	1	G → R. Corresponds to variant rs7250872 [ dbSNP | Ensembl ].		VAR_055544
	Natural variant	618	1	V → I. Corresponds to variant rs8100856 [ dbSNP | Ensembl ].		VAR_055545

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 5, 2010. Version 4. Checksum: 356B1972DD49DFF5	FASTA	1,300	146,752
	10 20 30 40 50 60 MGTGPAQTPR STRAGPEPSP APPGPGDTGD SDVTQEGSGP AGIRGGETVI RAGMGDSPGR 70 80 90 100 110 120 GAPERRHKAQ PGRARKYEWR PEGPTSMGSL GQREDLQDED RNSAFTWKVQ ANNRAYNGQF 130 140 150 160 170 180 KEKVILCWQR KKYKTNVIRT AKYNFYSFLP LNLYEQFHRV SNLFFLIIII LQSIPDISTL 190 200 210 220 230 240 PWFSLSTPMV CLLFIRATRD LVDDMGRHKS DRAINNRPCQ ILMGKSFKQK KWQDLCVGDV 250 260 270 280 290 300 VCLRKDNIVP ADMLLLASTE PSSLCYVETV DIDGETNLKF RQALMVTHKE LATIKKMASF 310 320 330 340 350 360 QGTVTCEAPN SRMHHFVGCL EWNDKKYSLD IGNLLLRGCR IRNTDTCYGL VIYAGFDTKI 370 380 390 400 410 420 MKNCGKIHLK RTKLDLLMNK LVVVIFISVV LVCLVLAFGF GFSVKEFKDH HYYLSGVHGS 430 440 450 460 470 480 SVAAESFFVF WSFLILLSVT IPMSMFILSE FIYLGNSVFI DWDVQMYYKP QDVPAKARST 490 500 510 520 530 540 SLNDHLGQVE YIFSDKTGTL TQNILTFNKC CISGRVYGPD SEATTRPKEN PYLWNKFADG 550 560 570 580 590 600 KLLFHNAALL HLVRTNGDEA VREFWRLLAI CHTVMVRESP RERPDQLLYQ AASPDEGALV 610 620 630 640 650 660 TAARNFGYVF LSRTQDTVTI MELGEERVYQ VLAIMDFNST RKRMSVLVRK PEGAICLYTK 670 680 690 700 710 720 GADTVIFERL HRRGAMEFAT EEALAAFAQE TLRTLCLAYR EVAEDIYEDW QQRHQEASLL 730 740 750 760 770 780 LQNRAQALQQ LLGATAIEDR LQDGVPETIK CLKKSNIKIW VLTGDKQETA VNIGFACELL 790 800 810 820 830 840 SENMLILEEK EISRILETYW ENSNNLLTRE SLSQVKLALV INGDFLDKLL VSLRKEPRAL 850 860 870 880 890 900 AQNVNMDEAW QELGQSRRDF LYARRLSLLC RRFGLPLAAP PAQDSRARRS SEVLQERAFV 910 920 930 940 950 960 DLASKCQAVI CCRVTPKQKA LIVALVKKYH QVVTLAIGDG ANDINMIKTA DVGVGLAGQE 970 980 990 1000 1010 1020 GMQAVQNSDF VLGQFCFLQR LLLVHGRWSY VRICKFLRYF FYKSMASMMV QVWFACYNGF 1030 1040 1050 1060 1070 1080 TGQPLYEGWF LALFNLLYST LPVLYIGLFE QDVSAEQSLE KPELYVVGQK DELFNYWVFV 1090 1100 1110 1120 1130 1140 QAIAHGVTTS LVNFFMTLWI SRDTAGPASF SDHQSFAVVV ALSCLLSITM EVILIIKYWT 1150 1160 1170 1180 1190 1200 ALCVATILLS LGFYAIMTTT TQSFWLFRVS PTTFPFLYAD LSVMSSPSIL LVVLLSVSIN 1210 1220 1230 1240 1250 1260 TFPVLALRVI FPALKELRAK EEKVEEGPSE EIFTMEPLPH VHRESRARRS SYAFSHREGY 1270 1280 1290 1300 ANLITQGTIL RRGPGVSSDI ASESLDPSDE EAASSPKESQ
	Isoform 2 [UniParc]. Checksum: F1A1C25A8DE696FC	FASTA	1,310	148,031
	10 20 30 40 50 60 MGTGPAQTPR STRAGPEPSP APPGPGDTGD SDVTQEGSGP AGIRGGETVI RAGMGDSPGR 70 80 90 100 110 120 GAPERRHKAQ PGRARKYEWR PEGPTSMGSL GQREDLQDED RNSAFTWKVQ ANNRAYNGQF 130 140 150 160 170 180 KEKVILCWQR KKYKTNVIRT AKYNFYSFLP LNLYEQFHRV SNLFFLIIII LQSIPDISTL 190 200 210 220 230 240 PWFSLSTPMV CLLFIRATRD LVDDMGRHKS DRAINNRPCQ ILMGKSFKQK KWQDLCVGDV 250 260 270 280 290 300 VCLRKDNIVP ADMLLLASTE PSSLCYVETV DIDGETNLKF RQALMVTHKE LATIKKMASF 310 320 330 340 350 360 QGTVTCEAPN SRMHHFVGCL EWNDKKYSLD IGNLLLRGCR IRNTDTCYGL VIYAGFDTKI 370 380 390 400 410 420 MKNCGKIHLK RTKLDLLMNK LVVVIFISVV LVCLVLAFGF GFSVKEFKDH HYYLSGVHGS 430 440 450 460 470 480 SVAAESFFVF WSFLILLSVT IPMSMFILSE FIYLGNSVFI DWDVQMYYKP QDVPAKARST 490 500 510 520 530 540 SLNDHLGQVE YIFSDKTGTL TQNILTFNKC CISGRVYGPD SEATTRPKEN PYLWNKFADG 550 560 570 580 590 600 KLLFHNAALL HLVRTNGDEA VREFWRLLAI CHTVMVRESP RERPDQLLYQ AASPDEGALV 610 620 630 640 650 660 TAARNFGYVF LSRTQDTVTI MELGEERVYQ VLAIMDFNST RKRMSVLVRK PEGAICLYTK 670 680 690 700 710 720 GADTVIFERL HRRGAMEFAT EEALAAFAQE TLRTLCLAYR EVAEDIYEDW QQRHQEASLL 730 740 750 760 770 780 LQNRAQALQQ VYNEMEQDLR LLGATAIEDR LQDGVPETIK CLKKSNIKIW VLTGDKQETA 790 800 810 820 830 840 VNIGFACELL SENMLILEEK EISRILETYW ENSNNLLTRE SLSQVKLALV INGDFLDKLL 850 860 870 880 890 900 VSLRKEPRAL AQNVNMDEAW QELGQSRRDF LYARRLSLLC RRFGLPLAAP PAQDSRARRS 910 920 930 940 950 960 SEVLQERAFV DLASKCQAVI CCRVTPKQKA LIVALVKKYH QVVTLAIGDG ANDINMIKTA 970 980 990 1000 1010 1020 DVGVGLAGQE GMQAVQNSDF VLGQFCFLQR LLLVHGRWSY VRICKFLRYF FYKSMASMMV 1030 1040 1050 1060 1070 1080 QVWFACYNGF TGQPLYEGWF LALFNLLYST LPVLYIGLFE QDVSAEQSLE KPELYVVGQK 1090 1100 1110 1120 1130 1140 DELFNYWVFV QAIAHGVTTS LVNFFMTLWI SRDTAGPASF SDHQSFAVVV ALSCLLSITM 1150 1160 1170 1180 1190 1200 EVILIIKYWT ALCVATILLS LGFYAIMTTT TQSFWLFRVS PTTFPFLYAD LSVMSSPSIL 1210 1220 1230 1240 1250 1260 LVVLLSVSIN TFPVLALRVI FPALKELRAK EEKVEEGPSE EIFTMEPLPH VHRESRARRS 1270 1280 1290 1300 1310 SYAFSHREGY ANLITQGTIL RRGPGVSSDI ASESLDPSDE EAASSPKESQ
	Isoform 3 [UniParc]. Checksum: 246752DB1DAC2E44	FASTA	1,263	143,705
	10 20 30 40 50 60 MGDSPGRGAP ERRHKAQPGR ARKYEWRPEG PTSMGSLGQR EDLQDEDRNS AFTWKVQANN 70 80 90 100 110 120 RAYNGQFKEK VILCWQRKKY KTNVIRTAKY NFYSFLPLNL YEQFHRVSNL FFLIIIILQS 130 140 150 160 170 180 IPDISTLPWF SLSTPMVCLL FIRATRDLVD DMGRHKSDRA INNRPCQILM GKSFKQKKWQ 190 200 210 220 230 240 DLCVGDVVCL RKDNIVPADM LLLASTEPSS LCYVETVDID GETNLKFRQA LMVTHKELAT 250 260 270 280 290 300 IKKMASFQGT VTCEAPNSRM HHFVGCLEWN DKKYSLDIGN LLLRGCRIRN TDTCYGLVIY 310 320 330 340 350 360 ADGYMFVGFD TKIMKNCGKI HLKRTKLDLL MNKLVVVIFI SVVLVCLVLA FGFGFSVKEF 370 380 390 400 410 420 KDHHYYLSGV HGSSVAAESF FVFWSFLILL SVTIPMSMFI LSEFIYLGNS VFIDWDVQMY 430 440 450 460 470 480 YKPQDVPAKA RSTSLNDHLG QVEYIFSDKT GTLTQNILTF NKCCISGRVY GPDSEATTRP 490 500 510 520 530 540 KENPYLWNKF ADGKLLFHNA ALLHLVRTNG DEAVREFWRL LAICHTVMVR ESPRERPDQL 550 560 570 580 590 600 LYQAASPDEG ALVTAARNFG YVFLSRTQDT VTIMELGEER VYQVLAIMDF NSTRKRMSVL 610 620 630 640 650 660 VRKPEGAICL YTKGADTVIF ERLHRRGAME FATEEALAAF AQETLRTLCL AYREVAEDIY 670 680 690 700 710 720 EDWQQRHQEA SLLLQNRAQA LQQVYNEMEQ DLRLLGATAI EDRLQDGVPE TIKCLKKSNI 730 740 750 760 770 780 KIWVLTGDKQ ETAVNIGFAC ELLSENMLIL EEKEISRILE TYWENSNNLL TRESLSQVKL 790 800 810 820 830 840 ALVINGDFLD KLLVSLRKEP RALAQNVNMD EAWQELGQSR RDFLYARRLS LLCRRFGLPL 850 860 870 880 890 900 AAPPAQDSRA RRSSEVLQER AFVDLASKCQ AVICCRVTPK QKALIVALVK KYHQVVTLAI 910 920 930 940 950 960 GDGANDINMI KTADVGVGLA GQEGMQAVQN SDFVLGQFCF LQRLLLVHGR WSYVRICKFL 970 980 990 1000 1010 1020 RYFFYKSMAS MMVQVWFACY NGFTGQPLYE GWFLALFNLL YSTLPVLYIG LFEQDVSAEQ 1030 1040 1050 1060 1070 1080 SLEKPELYVV GQKDELFNYW VFVQAIAHGV TTSLVNFFMT LWISRDTAGP ASFSDHQSFA 1090 1100 1110 1120 1130 1140 VVVALSCLLS ITMEVILIIK YWTALCVATI LLSLGFYAIM TTTTQSFWLF RVSPTTFPFL 1150 1160 1170 1180 1190 1200 YADLSVMSSP SILLVVLLSV SINTFPVLAL RVIFPALKEL RAKEEKVEEG PSEEIFTMEP 1210 1220 1230 1240 1250 1260 LPHVHRESRA RRSSYAFSHR EGYANLITQG TILRRGPGVS SDIASESLDP SDEEAASSPK ESQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"FIC1, a P-type ATPase linked to cholestatic liver disease, has homologues (ATP8B2 and ATP8B3) expressed throughout the body." Harris M.J., Arias I.M. Biochim. Biophys. Acta 1633:127-131(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY.
[2]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Eye and Testis.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 968-1300. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY302538 mRNA. Translation: AAQ19028.1. AC004755 Genomic DNA. Translation: AAC17601.1. Sequence problems. AC012615 Genomic DNA. No translation available. CH471139 Genomic DNA. Translation: EAW69455.1. AK057452 mRNA. Translation: BAB71492.1. Different initiation. BC035162 mRNA. Translation: AAH35162.3.
IPI	IPI00216974. IPI00237913.
RefSeq	NP_001171473.1. NM_001178002.2. NP_620168.1. NM_138813.3.
UniGene	Hs.306212.
3D structure databases
ProteinModelPortal	O60423.
SMR	O60423. Positions 869-1086.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000311336.
PTM databases
PhosphoSite	O60423.
Proteomic databases
PaxDb	O60423.
PRIDE	O60423.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000310127; ENSP00000311336; ENSG00000130270. ENST00000525591; ENSP00000437115; ENSG00000130270. ENST00000539485; ENSP00000443574; ENSG00000130270.
GeneID	148229.
KEGG	hsa:148229.
UCSC	uc002ltw.3. human.
Organism-specific databases
CTD	148229.
GeneCards	GC19M001733.
H-InvDB	HIX0202756.
HGNC	HGNC:13535. ATP8B3.
MIM	605866. gene.
neXtProt	NX_O60423.
PharmGKB	PA25168.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0474.
HOGENOM	HOG000202528.
HOVERGEN	HBG050601.
InParanoid	O60423.
KO	K01530.
OMA	VLAQFCF.
OrthoDB	EOG43BMN2.
Enzyme and pathway databases
Reactome	REACT_15518. Transmembrane transport of small molecules.
Gene expression databases
ArrayExpress	O60423.
Bgee	O60423.
CleanEx	HS_ATP8B3.
Genevestigator	O60423.
GermOnline	ENSG00000130270. Homo sapiens.
Family and domain databases
Gene3D	2.70.150.10. 2 hits. 3.40.1110.10. 1 hit. 3.40.50.1000. 2 hits.
InterPro	IPR023299. ATPase_P-typ_cyto_domN. IPR018303. ATPase_P-typ_P_site. IPR006539. ATPase_P-typ_Plipid-transp. IPR008250. ATPase_P-typ_transduc_dom_A. IPR001757. Cation_transp_P_typ_ATPase. IPR023214. HAD-like_dom. [Graphical view]
PANTHER	PTHR24092. PTHR24092. 1 hit.
Pfam	PF00122. E1-E2_ATPase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE.
SUPFAM	SSF81660. ATPase_cation_domN. 1 hit. SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR01652. ATPase-Plipid. 1 hit. TIGR01494. ATPase_P-type. 1 hit.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ATP8B3. human.
GenomeRNAi	148229.
NextBio	85875.
SOURCE	Search...

Entry information

Entry name

AT8B3_HUMAN

Accession

Primary (citable) accession number: O60423
Secondary accession number(s): Q7Z485 , Q8IVB8, Q8N4Y8, Q96M22

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	October 5, 2010
Last modified:	May 1, 2013
This is version 124 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.