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O60423

- AT8B3_HUMAN

UniProt

O60423 - AT8B3_HUMAN

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Protein

Phospholipid-transporting ATPase IK

Gene

ATP8B3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

P4-ATPase flippase which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. May be responsible for the maintenance of asymmetric distribution of phosphatidylserine (PS) in spermatozoa membranes. Involved in acrosome reactions and binding of spermatozoa to zona pellucida (By similarity).By similarity

Catalytic activityi

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei495 – 49514-aspartylphosphate intermediateBy similarity
Metal bindingi939 – 9391MagnesiumBy similarity
Metal bindingi943 – 9431MagnesiumBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cation-transporting ATPase activity Source: InterPro
  3. magnesium ion binding Source: InterPro
  4. phospholipid-translocating ATPase activity Source: UniProtKB-EC

GO - Biological processi

  1. binding of sperm to zona pellucida Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_25149. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid-transporting ATPase IK (EC:3.6.3.1)
Alternative name(s):
ATPase class I type 8B member 3
Gene namesi
Name:ATP8B3
Synonyms:ATP1K, FOS37502_2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:13535. ATP8B3.

Subcellular locationi

Cytoplasmic vesiclesecretory vesicleacrosome membrane By similarity; Multi-pass membrane protein By similarity. Endoplasmic reticulum 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 149149CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei150 – 17122HelicalSequence AnalysisAdd
BLAST
Topological domaini172 – 1776Exoplasmic loopSequence Analysis
Transmembranei178 – 19720HelicalSequence AnalysisAdd
BLAST
Topological domaini198 – 381184CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei382 – 40322HelicalSequence AnalysisAdd
BLAST
Topological domaini404 – 43027Exoplasmic loopSequence AnalysisAdd
BLAST
Transmembranei431 – 45222HelicalSequence AnalysisAdd
BLAST
Topological domaini453 – 995543CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei996 – 101621HelicalSequence AnalysisAdd
BLAST
Topological domaini1017 – 102812Exoplasmic loopSequence AnalysisAdd
BLAST
Transmembranei1029 – 104820HelicalSequence AnalysisAdd
BLAST
Topological domaini1049 – 107830CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei1079 – 110022HelicalSequence AnalysisAdd
BLAST
Topological domaini1101 – 111212Exoplasmic loopSequence AnalysisAdd
BLAST
Transmembranei1113 – 113523HelicalSequence AnalysisAdd
BLAST
Topological domaini1136 – 11416CytoplasmicSequence Analysis
Transmembranei1142 – 116221HelicalSequence AnalysisAdd
BLAST
Topological domaini1163 – 118220Exoplasmic loopSequence AnalysisAdd
BLAST
Transmembranei1183 – 120725HelicalSequence AnalysisAdd
BLAST
Topological domaini1208 – 130093CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. acrosomal vesicle Source: Ensembl
  2. endoplasmic reticulum Source: UniProtKB-KW
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25168.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13001300Phospholipid-transporting ATPase IKPRO_0000046367Add
BLAST

Proteomic databases

PaxDbiO60423.
PRIDEiO60423.

PTM databases

PhosphoSiteiO60423.

Expressioni

Tissue specificityi

Isoform 3 was only detected in testis.1 Publication

Gene expression databases

BgeeiO60423.
CleanExiHS_ATP8B3.
ExpressionAtlasiO60423. baseline and differential.
GenevestigatoriO60423.

Organism-specific databases

HPAiHPA041992.
HPA043582.

Interactioni

Protein-protein interaction databases

BioGridi127132. 1 interaction.
MINTiMINT-4656966.
STRINGi9606.ENSP00000311336.

Structurei

3D structure databases

ProteinModelPortaliO60423.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0474.
GeneTreeiENSGT00770000120474.
HOGENOMiHOG000202528.
HOVERGENiHBG050601.
InParanoidiO60423.
KOiK01530.
OMAiKENPYLW.
OrthoDBiEOG7RRF68.
PhylomeDBiO60423.
TreeFamiTF300654.

Family and domain databases

Gene3Di2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR006539. ATPase_P-typ_Plipid-transp.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view]
PANTHERiPTHR24092. PTHR24092. 1 hit.
PfamiPF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 2 hits.
TIGRFAMsiTIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O60423-2) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGTGPAQTPR STRAGPEPSP APPGPGDTGD SDVTQEGSGP AGIRGGETVI
60 70 80 90 100
RAGMGDSPGR GAPERRHKAQ PGRARKYEWR PEGPTSMGSL GQREDLQDED
110 120 130 140 150
RNSAFTWKVQ ANNRAYNGQF KEKVILCWQR KKYKTNVIRT AKYNFYSFLP
160 170 180 190 200
LNLYEQFHRV SNLFFLIIII LQSIPDISTL PWFSLSTPMV CLLFIRATRD
210 220 230 240 250
LVDDMGRHKS DRAINNRPCQ ILMGKSFKQK KWQDLCVGDV VCLRKDNIVP
260 270 280 290 300
ADMLLLASTE PSSLCYVETV DIDGETNLKF RQALMVTHKE LATIKKMASF
310 320 330 340 350
QGTVTCEAPN SRMHHFVGCL EWNDKKYSLD IGNLLLRGCR IRNTDTCYGL
360 370 380 390 400
VIYAGFDTKI MKNCGKIHLK RTKLDLLMNK LVVVIFISVV LVCLVLAFGF
410 420 430 440 450
GFSVKEFKDH HYYLSGVHGS SVAAESFFVF WSFLILLSVT IPMSMFILSE
460 470 480 490 500
FIYLGNSVFI DWDVQMYYKP QDVPAKARST SLNDHLGQVE YIFSDKTGTL
510 520 530 540 550
TQNILTFNKC CISGRVYGPD SEATTRPKEN PYLWNKFADG KLLFHNAALL
560 570 580 590 600
HLVRTNGDEA VREFWRLLAI CHTVMVRESP RERPDQLLYQ AASPDEGALV
610 620 630 640 650
TAARNFGYVF LSRTQDTVTI MELGEERVYQ VLAIMDFNST RKRMSVLVRK
660 670 680 690 700
PEGAICLYTK GADTVIFERL HRRGAMEFAT EEALAAFAQE TLRTLCLAYR
710 720 730 740 750
EVAEDIYEDW QQRHQEASLL LQNRAQALQQ LLGATAIEDR LQDGVPETIK
760 770 780 790 800
CLKKSNIKIW VLTGDKQETA VNIGFACELL SENMLILEEK EISRILETYW
810 820 830 840 850
ENSNNLLTRE SLSQVKLALV INGDFLDKLL VSLRKEPRAL AQNVNMDEAW
860 870 880 890 900
QELGQSRRDF LYARRLSLLC RRFGLPLAAP PAQDSRARRS SEVLQERAFV
910 920 930 940 950
DLASKCQAVI CCRVTPKQKA LIVALVKKYH QVVTLAIGDG ANDINMIKTA
960 970 980 990 1000
DVGVGLAGQE GMQAVQNSDF VLGQFCFLQR LLLVHGRWSY VRICKFLRYF
1010 1020 1030 1040 1050
FYKSMASMMV QVWFACYNGF TGQPLYEGWF LALFNLLYST LPVLYIGLFE
1060 1070 1080 1090 1100
QDVSAEQSLE KPELYVVGQK DELFNYWVFV QAIAHGVTTS LVNFFMTLWI
1110 1120 1130 1140 1150
SRDTAGPASF SDHQSFAVVV ALSCLLSITM EVILIIKYWT ALCVATILLS
1160 1170 1180 1190 1200
LGFYAIMTTT TQSFWLFRVS PTTFPFLYAD LSVMSSPSIL LVVLLSVSIN
1210 1220 1230 1240 1250
TFPVLALRVI FPALKELRAK EEKVEEGPSE EIFTMEPLPH VHRESRARRS
1260 1270 1280 1290 1300
SYAFSHREGY ANLITQGTIL RRGPGVSSDI ASESLDPSDE EAASSPKESQ
Length:1,300
Mass (Da):146,752
Last modified:October 5, 2010 - v4
Checksum:i356B1972DD49DFF5
GO
Isoform 2 (identifier: O60423-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     730-730: Q → QVYNEMEQDLR

Note: No experimental confirmation available.

Show »
Length:1,310
Mass (Da):148,031
Checksum:iF1A1C25A8DE696FC
GO
Isoform 3 (identifier: O60423-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: Missing.
     354-354: A → ADGYMFV
     730-730: Q → QVYNEMEQDLR

Note: No experimental confirmation available.

Show »
Length:1,263
Mass (Da):143,705
Checksum:i246752DB1DAC2E44
GO

Sequence cautioni

The sequence AAC17601.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence BAB71492.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti45 – 451G → R.
Corresponds to variant rs7250872 [ dbSNP | Ensembl ].
VAR_055544
Natural varianti618 – 6181V → I.
Corresponds to variant rs8100856 [ dbSNP | Ensembl ].
VAR_055545

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5353Missing in isoform 3. 1 PublicationVSP_043554Add
BLAST
Alternative sequencei354 – 3541A → ADGYMFV in isoform 3. 1 PublicationVSP_043555
Alternative sequencei730 – 7301Q → QVYNEMEQDLR in isoform 2 and isoform 3. 1 PublicationVSP_039716

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY302538 mRNA. Translation: AAQ19028.1.
AC004755 Genomic DNA. Translation: AAC17601.1. Sequence problems.
AC012615 Genomic DNA. No translation available.
CH471139 Genomic DNA. Translation: EAW69455.1.
AK057452 mRNA. Translation: BAB71492.1. Different initiation.
BC035162 mRNA. Translation: AAH35162.3.
CCDSiCCDS45901.1. [O60423-2]
CCDS54196.1. [O60423-3]
RefSeqiNP_001171473.1. NM_001178002.2. [O60423-3]
NP_620168.1. NM_138813.3. [O60423-2]
XP_006722717.1. XM_006722654.1. [O60423-1]
XP_006722718.1. XM_006722655.1. [O60423-1]
UniGeneiHs.306212.

Genome annotation databases

EnsembliENST00000310127; ENSP00000311336; ENSG00000130270. [O60423-2]
ENST00000525591; ENSP00000437115; ENSG00000130270. [O60423-3]
GeneIDi148229.
KEGGihsa:148229.
UCSCiuc002ltv.4. human. [O60423-3]
uc002ltw.4. human. [O60423-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY302538 mRNA. Translation: AAQ19028.1 .
AC004755 Genomic DNA. Translation: AAC17601.1 . Sequence problems.
AC012615 Genomic DNA. No translation available.
CH471139 Genomic DNA. Translation: EAW69455.1 .
AK057452 mRNA. Translation: BAB71492.1 . Different initiation.
BC035162 mRNA. Translation: AAH35162.3 .
CCDSi CCDS45901.1. [O60423-2 ]
CCDS54196.1. [O60423-3 ]
RefSeqi NP_001171473.1. NM_001178002.2. [O60423-3 ]
NP_620168.1. NM_138813.3. [O60423-2 ]
XP_006722717.1. XM_006722654.1. [O60423-1 ]
XP_006722718.1. XM_006722655.1. [O60423-1 ]
UniGenei Hs.306212.

3D structure databases

ProteinModelPortali O60423.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127132. 1 interaction.
MINTi MINT-4656966.
STRINGi 9606.ENSP00000311336.

PTM databases

PhosphoSitei O60423.

Proteomic databases

PaxDbi O60423.
PRIDEi O60423.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000310127 ; ENSP00000311336 ; ENSG00000130270 . [O60423-2 ]
ENST00000525591 ; ENSP00000437115 ; ENSG00000130270 . [O60423-3 ]
GeneIDi 148229.
KEGGi hsa:148229.
UCSCi uc002ltv.4. human. [O60423-3 ]
uc002ltw.4. human. [O60423-2 ]

Organism-specific databases

CTDi 148229.
GeneCardsi GC19M001783.
H-InvDB HIX0202756.
HGNCi HGNC:13535. ATP8B3.
HPAi HPA041992.
HPA043582.
MIMi 605866. gene.
neXtProti NX_O60423.
PharmGKBi PA25168.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0474.
GeneTreei ENSGT00770000120474.
HOGENOMi HOG000202528.
HOVERGENi HBG050601.
InParanoidi O60423.
KOi K01530.
OMAi KENPYLW.
OrthoDBi EOG7RRF68.
PhylomeDBi O60423.
TreeFami TF300654.

Enzyme and pathway databases

Reactomei REACT_25149. Ion transport by P-type ATPases.

Miscellaneous databases

ChiTaRSi ATP8B3. human.
GeneWikii ATP8B3.
GenomeRNAii 148229.
NextBioi 85875.
PROi O60423.
SOURCEi Search...

Gene expression databases

Bgeei O60423.
CleanExi HS_ATP8B3.
ExpressionAtlasi O60423. baseline and differential.
Genevestigatori O60423.

Family and domain databases

Gene3Di 2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProi IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR006539. ATPase_P-typ_Plipid-transp.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view ]
PANTHERi PTHR24092. PTHR24092. 1 hit.
Pfami PF00122. E1-E2_ATPase. 1 hit.
[Graphical view ]
PRINTSi PR00119. CATATPASE.
SUPFAMi SSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 2 hits.
TIGRFAMsi TIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "FIC1, a P-type ATPase linked to cholestatic liver disease, has homologues (ATP8B2 and ATP8B3) expressed throughout the body."
    Harris M.J., Arias I.M.
    Biochim. Biophys. Acta 1633:127-131(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Eye and Testis.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 968-1300.
    Tissue: Testis.
  6. "Heteromeric interactions required for abundance and subcellular localization of human CDC50 proteins and class 1 P4-ATPases."
    van der Velden L.M., Wichers C.G., van Breevoort A.E., Coleman J.A., Molday R.S., Berger R., Klomp L.W., van de Graaf S.F.
    J. Biol. Chem. 285:40088-40096(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiAT8B3_HUMAN
AccessioniPrimary (citable) accession number: O60423
Secondary accession number(s): Q7Z485
, Q8IVB8, Q8N4Y8, Q96M22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 5, 2010
Last modified: November 26, 2014
This is version 139 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Association with flippase complex beta subunits TMEM30A and TMEM30A has not been detected, neither did their coexpression change the localization in ER.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3