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Protein

One cut domain family member 3

Gene

ONECUT3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transcriptional activator. Binds the consensus DNA sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi312 – 398CUTPROSITE-ProRule annotationAdd BLAST87
DNA bindingi414 – 473HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
R-HSA-210747 Regulation of gene expression in early pancreatic precursor cells

Names & Taxonomyi

Protein namesi
Recommended name:
One cut domain family member 3
Alternative name(s):
One cut homeobox 3
Transcription factor ONECUT-3
Short name:
OC-3
Gene namesi
Name:ONECUT3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000205922.4
HGNCiHGNC:13399 ONECUT3
MIMi611294 gene
neXtProtiNX_O60422

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000205922
PharmGKBiPA31926

Polymorphism and mutation databases

BioMutaiONECUT3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002712181 – 494One cut domain family member 3Add BLAST494

Proteomic databases

PaxDbiO60422
PeptideAtlasiO60422
PRIDEiO60422

PTM databases

iPTMnetiO60422
PhosphoSitePlusiO60422

Expressioni

Gene expression databases

BgeeiENSG00000205922
CleanExiHS_ONECUT3
GenevisibleiO60422 HS

Organism-specific databases

HPAiHPA059936

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000371786

Structurei

3D structure databases

ProteinModelPortaliO60422
SMRiO60422
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi37 – 315Gly-richAdd BLAST279
Compositional biasi141 – 247Pro-richAdd BLAST107

Sequence similaritiesi

Belongs to the CUT homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG2252 Eukaryota
ENOG410YWY4 LUCA
GeneTreeiENSGT00530000063019
HOGENOMiHOG000232114
HOVERGENiHBG005981
InParanoidiO60422
OMAiAMTMSCD
OrthoDBiEOG091G0E7H
PhylomeDBiO60422
TreeFamiTF318206

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR003350 CUT_dom
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR010982 Lambda_DNA-bd_dom_sf
PfamiView protein in Pfam
PF02376 CUT, 1 hit
PF00046 Homeobox, 1 hit
SMARTiView protein in SMART
SM01109 CUT, 1 hit
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF47413 SSF47413, 1 hit
PROSITEiView protein in PROSITE
PS51042 CUT, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

O60422-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELSLESLGG LHSVAHAQAG ELLSPGHARS AAAQHRGLVA PGRPGLVAGM
60 70 80 90 100
ASLLDGGGGG GGGGAGGAGG AGSAGGGADF RGELAGPLHP AMGMACEAPG
110 120 130 140 150
LGGTYTTLTP LQHLPPLAAV ADKFHQHAAA AAVAGAHGGH PHAHPHPAAA
160 170 180 190 200
PPPPPPPQRL AASVSGSFTL MRDERAALAS VGHLYGPYGK ELPAMGSPLS
210 220 230 240 250
PLPNALPPAL HGAPQPPPPP PPPPLAAYGP PGHLAGDKLL PPAAFEPHAA
260 270 280 290 300
LLGRAEDALA RGLPGGGGGT GSGGAGSGSA AGLLAPLGGL AAAGAHGPHG
310 320 330 340 350
GGGGPGGSGG GPSAGAAAEE INTKEVAQRI TAELKRYSIP QAIFAQRILC
360 370 380 390 400
RSQGTLSDLL RNPKPWSKLK SGRETFRRMW KWLQEPEFQR MSALRLAACK
410 420 430 440 450
RKEQEQQKER ALQPKKQRLV FTDLQRRTLI AIFKENKRPS KEMQVTISQQ
460 470 480 490
LGLELNTVSN FFMNARRRCM NRWAEEPSTA PGGPAGATAT FSKA
Length:494
Mass (Da):50,037
Last modified:January 9, 2007 - v2
Checksum:iFB97DF2CBA336B82
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004755 Genomic DNA Translation: AAC17602.1
AC005256 Genomic DNA No translation available.
CCDSiCCDS45900.1
RefSeqiNP_001073957.1, NM_001080488.1
UniGeneiHs.654347

Genome annotation databases

EnsembliENST00000382349; ENSP00000371786; ENSG00000205922
GeneIDi390874
KEGGihsa:390874
UCSCiuc010xgr.3 human

Similar proteinsi

Entry informationi

Entry nameiONEC3_HUMAN
AccessioniPrimary (citable) accession number: O60422
Secondary accession number(s): A8MZM7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: May 23, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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