Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

One cut domain family member 3

Gene

ONECUT3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Transcriptional activator. Binds the consensus DNA sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi312 – 398CUTPROSITE-ProRule annotationAdd BLAST87
DNA bindingi414 – 473HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:G66-31057-MONOMER.
ReactomeiR-HSA-210744. Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells.
R-HSA-210747. Regulation of gene expression in early pancreatic precursor cells.

Names & Taxonomyi

Protein namesi
Recommended name:
One cut domain family member 3
Alternative name(s):
One cut homeobox 3
Transcription factor ONECUT-3
Short name:
OC-3
Gene namesi
Name:ONECUT3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:13399. ONECUT3.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000205922.
PharmGKBiPA31926.

Polymorphism and mutation databases

BioMutaiONECUT3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002712181 – 494One cut domain family member 3Add BLAST494

Proteomic databases

PaxDbiO60422.
PeptideAtlasiO60422.
PRIDEiO60422.

PTM databases

iPTMnetiO60422.
PhosphoSitePlusiO60422.

Expressioni

Gene expression databases

BgeeiENSG00000205922.
CleanExiHS_ONECUT3.
GenevisibleiO60422. HS.

Organism-specific databases

HPAiHPA059936.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000371786.

Structurei

3D structure databases

ProteinModelPortaliO60422.
SMRiO60422.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi37 – 315Gly-richAdd BLAST279
Compositional biasi141 – 247Pro-richAdd BLAST107

Sequence similaritiesi

Belongs to the CUT homeobox family.Curated
Contains 1 CUT DNA-binding domain.PROSITE-ProRule annotation
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG2252. Eukaryota.
ENOG410YWY4. LUCA.
GeneTreeiENSGT00530000063019.
HOGENOMiHOG000232114.
HOVERGENiHBG005981.
InParanoidiO60422.
OMAiAHGPHGG.
OrthoDBiEOG091G0E7H.
PhylomeDBiO60422.
TreeFamiTF318206.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR003350. CUT_dom.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view]
PfamiPF02376. CUT. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM01109. CUT. 1 hit.
SM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS51042. CUT. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O60422-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELSLESLGG LHSVAHAQAG ELLSPGHARS AAAQHRGLVA PGRPGLVAGM
60 70 80 90 100
ASLLDGGGGG GGGGAGGAGG AGSAGGGADF RGELAGPLHP AMGMACEAPG
110 120 130 140 150
LGGTYTTLTP LQHLPPLAAV ADKFHQHAAA AAVAGAHGGH PHAHPHPAAA
160 170 180 190 200
PPPPPPPQRL AASVSGSFTL MRDERAALAS VGHLYGPYGK ELPAMGSPLS
210 220 230 240 250
PLPNALPPAL HGAPQPPPPP PPPPLAAYGP PGHLAGDKLL PPAAFEPHAA
260 270 280 290 300
LLGRAEDALA RGLPGGGGGT GSGGAGSGSA AGLLAPLGGL AAAGAHGPHG
310 320 330 340 350
GGGGPGGSGG GPSAGAAAEE INTKEVAQRI TAELKRYSIP QAIFAQRILC
360 370 380 390 400
RSQGTLSDLL RNPKPWSKLK SGRETFRRMW KWLQEPEFQR MSALRLAACK
410 420 430 440 450
RKEQEQQKER ALQPKKQRLV FTDLQRRTLI AIFKENKRPS KEMQVTISQQ
460 470 480 490
LGLELNTVSN FFMNARRRCM NRWAEEPSTA PGGPAGATAT FSKA
Length:494
Mass (Da):50,037
Last modified:January 9, 2007 - v2
Checksum:iFB97DF2CBA336B82
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004755 Genomic DNA. Translation: AAC17602.1.
AC005256 Genomic DNA. No translation available.
CCDSiCCDS45900.1.
RefSeqiNP_001073957.1. NM_001080488.1.
UniGeneiHs.654347.

Genome annotation databases

EnsembliENST00000382349; ENSP00000371786; ENSG00000205922.
GeneIDi390874.
KEGGihsa:390874.
UCSCiuc010xgr.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004755 Genomic DNA. Translation: AAC17602.1.
AC005256 Genomic DNA. No translation available.
CCDSiCCDS45900.1.
RefSeqiNP_001073957.1. NM_001080488.1.
UniGeneiHs.654347.

3D structure databases

ProteinModelPortaliO60422.
SMRiO60422.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000371786.

PTM databases

iPTMnetiO60422.
PhosphoSitePlusiO60422.

Polymorphism and mutation databases

BioMutaiONECUT3.

Proteomic databases

PaxDbiO60422.
PeptideAtlasiO60422.
PRIDEiO60422.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382349; ENSP00000371786; ENSG00000205922.
GeneIDi390874.
KEGGihsa:390874.
UCSCiuc010xgr.3. human.

Organism-specific databases

CTDi390874.
GeneCardsiONECUT3.
HGNCiHGNC:13399. ONECUT3.
HPAiHPA059936.
MIMi611294. gene.
neXtProtiNX_O60422.
OpenTargetsiENSG00000205922.
PharmGKBiPA31926.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2252. Eukaryota.
ENOG410YWY4. LUCA.
GeneTreeiENSGT00530000063019.
HOGENOMiHOG000232114.
HOVERGENiHBG005981.
InParanoidiO60422.
OMAiAHGPHGG.
OrthoDBiEOG091G0E7H.
PhylomeDBiO60422.
TreeFamiTF318206.

Enzyme and pathway databases

BioCyciZFISH:G66-31057-MONOMER.
ReactomeiR-HSA-210744. Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells.
R-HSA-210747. Regulation of gene expression in early pancreatic precursor cells.

Miscellaneous databases

GenomeRNAii390874.
PROiO60422.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000205922.
CleanExiHS_ONECUT3.
GenevisibleiO60422. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR003350. CUT_dom.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view]
PfamiPF02376. CUT. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM01109. CUT. 1 hit.
SM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS51042. CUT. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiONEC3_HUMAN
AccessioniPrimary (citable) accession number: O60422
Secondary accession number(s): A8MZM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: November 2, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.