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Protein

Olfactory receptor 7C2

Gene

OR7C2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 7C2
Alternative name(s):
Olfactory receptor 19-18
Short name:
OR19-18
Olfactory receptor 7C3
Olfactory receptor OR19-22
Gene namesi
Name:OR7C2
Synonyms:OR7C3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:8374. OR7C2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence analysisAdd
BLAST
Transmembranei26 – 4621Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini47 – 548CytoplasmicSequence analysis
Transmembranei55 – 7521Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini76 – 9924ExtracellularSequence analysisAdd
BLAST
Transmembranei100 – 12021Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence analysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini161 – 19737ExtracellularSequence analysisAdd
BLAST
Transmembranei198 – 21720Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini218 – 23619CytoplasmicSequence analysisAdd
BLAST
Transmembranei237 – 25721Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini258 – 27013ExtracellularSequence analysisAdd
BLAST
Transmembranei271 – 29121Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini292 – 31928CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32625.

Polymorphism and mutation databases

BioMutaiOR7C2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 319319Olfactory receptor 7C2PRO_0000150647Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO60412.
PRIDEiO60412.

Expressioni

Gene expression databases

CleanExiHS_OR7C2.
GenevisibleiO60412. HS.

Organism-specific databases

HPAiHPA047295.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000248072.

Structurei

3D structure databases

ProteinModelPortaliO60412.
SMRiO60412. Positions 29-304.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVB1. Eukaryota.
ENOG410YBQN. LUCA.
GeneTreeiENSGT00760000118801.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiO60412.
KOiK04257.
OMAiMITFAGC.
OrthoDBiEOG7HXCR6.
PhylomeDBiO60412.
TreeFamiTF337210.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O60412-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERGNQTEVG NFLLLGFAED SDMQLLLHGL FLSMYLVTII GNLLIILTIS
60 70 80 90 100
SDSHLHTPMY FFLSNLSFAD ICFTSTTVPK MLVNIQTQSK MITFAGCLTQ
110 120 130 140 150
IFFFIAFGCL DNLLLTMTAY DRFVAICYPL HYTVIMNPRL CGLLVLGSWC
160 170 180 190 200
ISVMGSLLET LTILRLSFCT NMEIPHFFCD PSEVLKLACS DTFINNIVMY
210 220 230 240 250
FVTIVLGVFP LCGILFSYSQ IFSSVLRVSA RGQHKAFSTC GSHLSVVSLF
260 270 280 290 300
YGTGLGVYLS SAVTPPSRTS LAASVMYTMV TPMLNPFIYS LRNKDMKGSL
310
GRLLLRATSL KEGTIAKLS
Length:319
Mass (Da):35,323
Last modified:October 17, 2006 - v4
Checksum:i1FAF5A196B2B566C
GO

Sequence cautioni

The sequence DAA04611.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti168 – 1681F → S in AAC39626 (PubMed:9500546).Curated
Sequence conflicti168 – 1681F → S in AAK95030 (PubMed:12213199).Curated
Sequence conflicti200 – 2001Y → C in AAC39626 (PubMed:9500546).Curated
Sequence conflicti200 – 2001Y → C in AAK95030 (PubMed:12213199).Curated
Sequence conflicti229 – 2291S → SS in AAC39626 (PubMed:9500546).Curated
Sequence conflicti229 – 2291S → SS in AAK95030 (PubMed:12213199).Curated
Sequence conflicti238 – 2381S → T in AAC39626 (PubMed:9500546).Curated
Sequence conflicti238 – 2381S → T in AAK95030 (PubMed:12213199).Curated
Sequence conflicti277 – 2771Y → H in AAC39626 (PubMed:9500546).Curated
Sequence conflicti277 – 2771Y → H in AAK95030 (PubMed:12213199).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti118 – 1181T → M.
Corresponds to variant rs8113325 [ dbSNP | Ensembl ].
VAR_027808
Natural varianti122 – 1221R → H.
Corresponds to variant rs11883178 [ dbSNP | Ensembl ].
VAR_053234

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004659 Genomic DNA. Translation: AAC15755.1.
U86255 Genomic DNA. Translation: AAC39626.1.
AF399545 Genomic DNA. Translation: AAK95030.1.
BK004213 Genomic DNA. Translation: DAA04611.1. Different initiation.
CCDSiCCDS12320.1.
RefSeqiNP_036509.1. NM_012377.1.
UniGeneiHs.589620.

Genome annotation databases

EnsembliENST00000248072; ENSP00000248072; ENSG00000127529.
GeneIDi26658.
KEGGihsa:26658.
UCSCiuc010xoc.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004659 Genomic DNA. Translation: AAC15755.1.
U86255 Genomic DNA. Translation: AAC39626.1.
AF399545 Genomic DNA. Translation: AAK95030.1.
BK004213 Genomic DNA. Translation: DAA04611.1. Different initiation.
CCDSiCCDS12320.1.
RefSeqiNP_036509.1. NM_012377.1.
UniGeneiHs.589620.

3D structure databases

ProteinModelPortaliO60412.
SMRiO60412. Positions 29-304.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000248072.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR7C2.

Proteomic databases

PaxDbiO60412.
PRIDEiO60412.

Protocols and materials databases

DNASUi26658.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000248072; ENSP00000248072; ENSG00000127529.
GeneIDi26658.
KEGGihsa:26658.
UCSCiuc010xoc.2. human.

Organism-specific databases

CTDi26658.
GeneCardsiOR7C2.
HGNCiHGNC:8374. OR7C2.
HPAiHPA047295.
neXtProtiNX_O60412.
PharmGKBiPA32625.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVB1. Eukaryota.
ENOG410YBQN. LUCA.
GeneTreeiENSGT00760000118801.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiO60412.
KOiK04257.
OMAiMITFAGC.
OrthoDBiEOG7HXCR6.
PhylomeDBiO60412.
TreeFamiTF337210.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR7C2.
GenomeRNAii26658.
NextBioi49013.
PROiO60412.

Gene expression databases

CleanExiHS_OR7C2.
GenevisibleiO60412. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-282.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-282.
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR7C2_HUMAN
AccessioniPrimary (citable) accession number: O60412
Secondary accession number(s): O43881, Q6IFP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: October 17, 2006
Last modified: November 11, 2015
This is version 131 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.