ID   O10H3_HUMAN             Reviewed;         316 AA.
AC   O60404; Q2HIZ3; Q6IFQ0;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   24-JAN-2024, entry version 175.
DE   RecName: Full=Olfactory receptor 10H3;
DE   AltName: Full=Olfactory receptor OR19-24;
GN   Name=OR10H3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT MET-224.
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [4]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR10H3";
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DR   EMBL; AC004597; AAC14389.1; -; Genomic_DNA.
DR   EMBL; BC106707; AAI06708.1; -; mRNA.
DR   EMBL; BC113844; AAI13845.1; -; mRNA.
DR   EMBL; BK004212; DAA04610.1; -; Genomic_DNA.
DR   CCDS; CCDS12334.1; -.
DR   RefSeq; NP_039226.1; NM_013938.1.
DR   AlphaFoldDB; O60404; -.
DR   SMR; O60404; -.
DR   BioGRID; 117734; 8.
DR   IntAct; O60404; 6.
DR   STRING; 9606.ENSP00000493287; -.
DR   iPTMnet; O60404; -.
DR   PhosphoSitePlus; O60404; -.
DR   BioMuta; OR10H3; -.
DR   PaxDb; 9606-ENSP00000307130; -.
DR   PeptideAtlas; O60404; -.
DR   Antibodypedia; 54307; 29 antibodies from 11 providers.
DR   DNASU; 26532; -.
DR   Ensembl; ENST00000641646.1; ENSP00000493287.1; ENSG00000171936.3.
DR   GeneID; 26532; -.
DR   KEGG; hsa:26532; -.
DR   MANE-Select; ENST00000641646.1; ENSP00000493287.1; NM_013938.2; NP_039226.1.
DR   UCSC; uc010xoq.2; human.
DR   AGR; HGNC:8174; -.
DR   CTD; 26532; -.
DR   GeneCards; OR10H3; -.
DR   HGNC; HGNC:8174; OR10H3.
DR   HPA; ENSG00000171936; Not detected.
DR   neXtProt; NX_O60404; -.
DR   PharmGKB; PA31979; -.
DR   VEuPathDB; HostDB:ENSG00000171936; -.
DR   eggNOG; ENOG502SJHK; Eukaryota.
DR   GeneTree; ENSGT01060000248581; -.
DR   HOGENOM; CLU_012526_1_0_1; -.
DR   InParanoid; O60404; -.
DR   OMA; FVACAIQ; -.
DR   OrthoDB; 4514128at2759; -.
DR   PhylomeDB; O60404; -.
DR   TreeFam; TF338279; -.
DR   PathwayCommons; O60404; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   SignaLink; O60404; -.
DR   BioGRID-ORCS; 26532; 8 hits in 707 CRISPR screens.
DR   GeneWiki; OR10H3; -.
DR   GenomeRNAi; 26532; -.
DR   Pharos; O60404; Tdark.
DR   PRO; PR:O60404; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; O60404; Protein.
DR   Bgee; ENSG00000171936; Expressed in pancreatic ductal cell and 5 other cell types or tissues.
DR   ExpressionAtlas; O60404; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR26453; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR26453:SF705; OLFACTORY RECEPTOR 10H3; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   Genevisible; O60404; HS.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Membrane;
KW   Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..316
FT                   /note="Olfactory receptor 10H3"
FT                   /id="PRO_0000150704"
FT   TOPO_DOM        1..25
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..46
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        47..54
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        76..99
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        121..139
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..160
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        161..197
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        198..218
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        219..238
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..259
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        260..272
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        273..293
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        294..316
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DISULFID        98..190
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         7
FT                   /note="R -> S (in dbSNP:rs1966357)"
FT                   /id="VAR_024128"
FT   VARIANT         14
FT                   /note="L -> I (in dbSNP:rs2240227)"
FT                   /id="VAR_034288"
FT   VARIANT         54
FT                   /note="R -> H (in dbSNP:rs11670007)"
FT                   /id="VAR_034289"
FT   VARIANT         224
FT                   /note="V -> M (in dbSNP:rs2240228)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_020381"
FT   VARIANT         293
FT                   /note="S -> N (in dbSNP:rs2240229)"
FT                   /id="VAR_020382"
SQ   SEQUENCE   316 AA;  35721 MW;  D055291FB9B49BC3 CRC64;
     MPGQNYRTIS EFILSGFSAF PQQLLPVLFL LYLLMFLFTL LGNLLIMATV WIERRLHTPM
     YLFLCALSIS EILFTVAITP RMLADLLFTH RSITFVACAI QMFFSFMFGF THSFLLMVMG
     YDHYVTICHP LHYNMLMSPR GCAHLVAWTW AGGSVMGMMV TMMVFHLTFC GSNVIHHFLC
     HVLSLLKLAC GSKTSSVIMG VMLVCVTALI GCLFLIILSF VFIVAAILRI PSAEGRHKTF
     STCVSHLTVV VMHYSFASLI YLKPKGLHSM YSDALMATTY TVFTPFLSPI IFSLRNKELK
     NAINKNFCRR FCPLSS
//