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O60404

- O10H3_HUMAN

UniProt

O60404 - O10H3_HUMAN

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Protein

Olfactory receptor 10H3

Gene

OR10H3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10H3
Alternative name(s):
Olfactory receptor OR19-24
Gene namesi
Name:OR10H3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:8174. OR10H3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini47 – 548CytoplasmicSequence Analysis
Transmembranei55 – 7521Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini76 – 9924ExtracellularSequence AnalysisAdd
BLAST
Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini161 – 19737ExtracellularSequence AnalysisAdd
BLAST
Transmembranei198 – 21821Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini219 – 23820CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei239 – 25921Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini260 – 27213ExtracellularSequence AnalysisAdd
BLAST
Transmembranei273 – 29321Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini294 – 31623CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31979.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316Olfactory receptor 10H3PRO_0000150704Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiO60404.

Expressioni

Gene expression databases

BgeeiO60404.
CleanExiHS_OR10H3.
GenevestigatoriO60404.

Interactioni

Protein-protein interaction databases

BioGridi117734. 5 interactions.
STRINGi9606.ENSP00000307130.

Structurei

3D structure databases

ProteinModelPortaliO60404.
SMRiO60404. Positions 31-163.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG79272.
GeneTreeiENSGT00760000119043.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiO60404.
KOiK04257.
OMAiTVWIERR.
OrthoDBiEOG78PV9F.
PhylomeDBiO60404.
TreeFamiTF338279.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O60404-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPGQNYRTIS EFILSGFSAF PQQLLPVLFL LYLLMFLFTL LGNLLIMATV
60 70 80 90 100
WIERRLHTPM YLFLCALSIS EILFTVAITP RMLADLLFTH RSITFVACAI
110 120 130 140 150
QMFFSFMFGF THSFLLMVMG YDHYVTICHP LHYNMLMSPR GCAHLVAWTW
160 170 180 190 200
AGGSVMGMMV TMMVFHLTFC GSNVIHHFLC HVLSLLKLAC GSKTSSVIMG
210 220 230 240 250
VMLVCVTALI GCLFLIILSF VFIVAAILRI PSAEGRHKTF STCVSHLTVV
260 270 280 290 300
VMHYSFASLI YLKPKGLHSM YSDALMATTY TVFTPFLSPI IFSLRNKELK
310
NAINKNFCRR FCPLSS
Length:316
Mass (Da):35,721
Last modified:August 1, 1998 - v1
Checksum:iD055291FB9B49BC3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti7 – 71R → S.
Corresponds to variant rs1966357 [ dbSNP | Ensembl ].
VAR_024128
Natural varianti14 – 141L → I.
Corresponds to variant rs2240227 [ dbSNP | Ensembl ].
VAR_034288
Natural varianti54 – 541R → H.
Corresponds to variant rs11670007 [ dbSNP | Ensembl ].
VAR_034289
Natural varianti224 – 2241V → M.1 Publication
Corresponds to variant rs2240228 [ dbSNP | Ensembl ].
VAR_020381
Natural varianti293 – 2931S → N.
Corresponds to variant rs2240229 [ dbSNP | Ensembl ].
VAR_020382

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004597 Genomic DNA. Translation: AAC14389.1.
BC106707 mRNA. Translation: AAI06708.1.
BC113844 mRNA. Translation: AAI13845.1.
BK004212 Genomic DNA. Translation: DAA04610.1.
CCDSiCCDS12334.1.
RefSeqiNP_039226.1. NM_013938.1.
UniGeneiHs.553524.

Genome annotation databases

EnsembliENST00000305892; ENSP00000307130; ENSG00000171936.
GeneIDi26532.
KEGGihsa:26532.
UCSCiuc010xoq.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004597 Genomic DNA. Translation: AAC14389.1 .
BC106707 mRNA. Translation: AAI06708.1 .
BC113844 mRNA. Translation: AAI13845.1 .
BK004212 Genomic DNA. Translation: DAA04610.1 .
CCDSi CCDS12334.1.
RefSeqi NP_039226.1. NM_013938.1.
UniGenei Hs.553524.

3D structure databases

ProteinModelPortali O60404.
SMRi O60404. Positions 31-163.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117734. 5 interactions.
STRINGi 9606.ENSP00000307130.

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PRIDEi O60404.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000305892 ; ENSP00000307130 ; ENSG00000171936 .
GeneIDi 26532.
KEGGi hsa:26532.
UCSCi uc010xoq.2. human.

Organism-specific databases

CTDi 26532.
GeneCardsi GC19P015852.
HGNCi HGNC:8174. OR10H3.
neXtProti NX_O60404.
PharmGKBi PA31979.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG79272.
GeneTreei ENSGT00760000119043.
HOGENOMi HOG000041365.
HOVERGENi HBG017625.
InParanoidi O60404.
KOi K04257.
OMAi TVWIERR.
OrthoDBi EOG78PV9F.
PhylomeDBi O60404.
TreeFami TF338279.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR10H3.
GenomeRNAii 26532.
NextBioi 48880.
PROi O60404.

Gene expression databases

Bgeei O60404.
CleanExi HS_OR10H3.
Genevestigatori O60404.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-224.
  3. Cited for: IDENTIFICATION.
  4. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO10H3_HUMAN
AccessioniPrimary (citable) accession number: O60404
Secondary accession number(s): Q2HIZ3, Q6IFQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: August 1, 1998
Last modified: October 29, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3