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Protein

Olfactory receptor 10H3

Gene

OR10H3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10H3
Alternative name(s):
Olfactory receptor OR19-24
Gene namesi
Name:OR10H3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi

Organism-specific databases

EuPathDBiHostDB:ENSG00000171936.1
HGNCiHGNC:8174 OR10H3
neXtProtiNX_O60404

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 197ExtracellularSequence analysisAdd BLAST37
Transmembranei198 – 218Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini219 – 238CytoplasmicSequence analysisAdd BLAST20
Transmembranei239 – 259Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini260 – 272ExtracellularSequence analysisAdd BLAST13
Transmembranei273 – 293Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini294 – 316CytoplasmicSequence analysisAdd BLAST23

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31979

Polymorphism and mutation databases

BioMutaiOR10H3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507041 – 316Olfactory receptor 10H3Add BLAST316

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO60404
PeptideAtlasiO60404
PRIDEiO60404

PTM databases

iPTMnetiO60404
PhosphoSitePlusiO60404

Expressioni

Gene expression databases

BgeeiENSG00000171936
CleanExiHS_OR10H3
ExpressionAtlasiO60404 baseline and differential
GenevisibleiO60404 HS

Interactioni

Protein-protein interaction databases

BioGridi117734, 8 interactors
STRINGi9606.ENSP00000307130

Structurei

3D structure databases

ProteinModelPortaliO60404
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J91Z Eukaryota
ENOG4111CKD LUCA
GeneTreeiENSGT00760000119043
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiO60404
KOiK04257
OMAiTVWIERR
OrthoDBiEOG091G0EWJ
PhylomeDBiO60404
TreeFamiTF338279

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

O60404-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGQNYRTIS EFILSGFSAF PQQLLPVLFL LYLLMFLFTL LGNLLIMATV
60 70 80 90 100
WIERRLHTPM YLFLCALSIS EILFTVAITP RMLADLLFTH RSITFVACAI
110 120 130 140 150
QMFFSFMFGF THSFLLMVMG YDHYVTICHP LHYNMLMSPR GCAHLVAWTW
160 170 180 190 200
AGGSVMGMMV TMMVFHLTFC GSNVIHHFLC HVLSLLKLAC GSKTSSVIMG
210 220 230 240 250
VMLVCVTALI GCLFLIILSF VFIVAAILRI PSAEGRHKTF STCVSHLTVV
260 270 280 290 300
VMHYSFASLI YLKPKGLHSM YSDALMATTY TVFTPFLSPI IFSLRNKELK
310
NAINKNFCRR FCPLSS
Length:316
Mass (Da):35,721
Last modified:August 1, 1998 - v1
Checksum:iD055291FB9B49BC3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0241287R → S. Corresponds to variant dbSNP:rs1966357Ensembl.1
Natural variantiVAR_03428814L → I. Corresponds to variant dbSNP:rs2240227Ensembl.1
Natural variantiVAR_03428954R → H. Corresponds to variant dbSNP:rs11670007Ensembl.1
Natural variantiVAR_020381224V → M1 PublicationCorresponds to variant dbSNP:rs2240228Ensembl.1
Natural variantiVAR_020382293S → N. Corresponds to variant dbSNP:rs2240229Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004597 Genomic DNA Translation: AAC14389.1
BC106707 mRNA Translation: AAI06708.1
BC113844 mRNA Translation: AAI13845.1
BK004212 Genomic DNA Translation: DAA04610.1
CCDSiCCDS12334.1
RefSeqiNP_039226.1, NM_013938.1
UniGeneiHs.553524

Genome annotation databases

EnsembliENST00000305892; ENSP00000307130; ENSG00000171936
ENST00000641646; ENSP00000493287; ENSG00000171936
GeneIDi26532
KEGGihsa:26532
UCSCiuc010xoq.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiO10H3_HUMAN
AccessioniPrimary (citable) accession number: O60404
Secondary accession number(s): Q2HIZ3, Q6IFQ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: August 1, 1998
Last modified: February 28, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

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