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Protein

Olfactory receptor 10H3

Gene

OR10H3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171936-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10H3
Alternative name(s):
Olfactory receptor OR19-24
Gene namesi
Name:OR10H3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:8174. OR10H3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 197ExtracellularSequence analysisAdd BLAST37
Transmembranei198 – 218Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini219 – 238CytoplasmicSequence analysisAdd BLAST20
Transmembranei239 – 259Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini260 – 272ExtracellularSequence analysisAdd BLAST13
Transmembranei273 – 293Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini294 – 316CytoplasmicSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000171936.
PharmGKBiPA31979.

Polymorphism and mutation databases

BioMutaiOR10H3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507041 – 316Olfactory receptor 10H3Add BLAST316

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO60404.
PRIDEiO60404.

PTM databases

iPTMnetiO60404.
PhosphoSitePlusiO60404.

Expressioni

Gene expression databases

BgeeiENSG00000171936.
CleanExiHS_OR10H3.
ExpressionAtlasiO60404. baseline.
GenevisibleiO60404. HS.

Interactioni

Protein-protein interaction databases

BioGridi117734. 7 interactors.
STRINGi9606.ENSP00000307130.

Structurei

3D structure databases

ProteinModelPortaliO60404.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J91Z. Eukaryota.
ENOG4111CKD. LUCA.
GeneTreeiENSGT00760000119043.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiO60404.
KOiK04257.
OMAiTVWIERR.
OrthoDBiEOG091G0EWJ.
PhylomeDBiO60404.
TreeFamiTF338279.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O60404-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGQNYRTIS EFILSGFSAF PQQLLPVLFL LYLLMFLFTL LGNLLIMATV
60 70 80 90 100
WIERRLHTPM YLFLCALSIS EILFTVAITP RMLADLLFTH RSITFVACAI
110 120 130 140 150
QMFFSFMFGF THSFLLMVMG YDHYVTICHP LHYNMLMSPR GCAHLVAWTW
160 170 180 190 200
AGGSVMGMMV TMMVFHLTFC GSNVIHHFLC HVLSLLKLAC GSKTSSVIMG
210 220 230 240 250
VMLVCVTALI GCLFLIILSF VFIVAAILRI PSAEGRHKTF STCVSHLTVV
260 270 280 290 300
VMHYSFASLI YLKPKGLHSM YSDALMATTY TVFTPFLSPI IFSLRNKELK
310
NAINKNFCRR FCPLSS
Length:316
Mass (Da):35,721
Last modified:August 1, 1998 - v1
Checksum:iD055291FB9B49BC3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0241287R → S.Corresponds to variant rs1966357dbSNPEnsembl.1
Natural variantiVAR_03428814L → I.Corresponds to variant rs2240227dbSNPEnsembl.1
Natural variantiVAR_03428954R → H.Corresponds to variant rs11670007dbSNPEnsembl.1
Natural variantiVAR_020381224V → M.1 PublicationCorresponds to variant rs2240228dbSNPEnsembl.1
Natural variantiVAR_020382293S → N.Corresponds to variant rs2240229dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004597 Genomic DNA. Translation: AAC14389.1.
BC106707 mRNA. Translation: AAI06708.1.
BC113844 mRNA. Translation: AAI13845.1.
BK004212 Genomic DNA. Translation: DAA04610.1.
CCDSiCCDS12334.1.
RefSeqiNP_039226.1. NM_013938.1.
UniGeneiHs.553524.

Genome annotation databases

EnsembliENST00000305892; ENSP00000307130; ENSG00000171936.
GeneIDi26532.
KEGGihsa:26532.
UCSCiuc010xoq.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004597 Genomic DNA. Translation: AAC14389.1.
BC106707 mRNA. Translation: AAI06708.1.
BC113844 mRNA. Translation: AAI13845.1.
BK004212 Genomic DNA. Translation: DAA04610.1.
CCDSiCCDS12334.1.
RefSeqiNP_039226.1. NM_013938.1.
UniGeneiHs.553524.

3D structure databases

ProteinModelPortaliO60404.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117734. 7 interactors.
STRINGi9606.ENSP00000307130.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO60404.
PhosphoSitePlusiO60404.

Polymorphism and mutation databases

BioMutaiOR10H3.

Proteomic databases

PaxDbiO60404.
PRIDEiO60404.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305892; ENSP00000307130; ENSG00000171936.
GeneIDi26532.
KEGGihsa:26532.
UCSCiuc010xoq.2. human.

Organism-specific databases

CTDi26532.
GeneCardsiOR10H3.
HGNCiHGNC:8174. OR10H3.
neXtProtiNX_O60404.
OpenTargetsiENSG00000171936.
PharmGKBiPA31979.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J91Z. Eukaryota.
ENOG4111CKD. LUCA.
GeneTreeiENSGT00760000119043.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiO60404.
KOiK04257.
OMAiTVWIERR.
OrthoDBiEOG091G0EWJ.
PhylomeDBiO60404.
TreeFamiTF338279.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171936-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR10H3.
GenomeRNAii26532.
PROiO60404.

Gene expression databases

BgeeiENSG00000171936.
CleanExiHS_OR10H3.
ExpressionAtlasiO60404. baseline.
GenevisibleiO60404. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO10H3_HUMAN
AccessioniPrimary (citable) accession number: O60404
Secondary accession number(s): Q2HIZ3, Q6IFQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: August 1, 1998
Last modified: November 30, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.