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O60404

- O10H3_HUMAN

UniProt

O60404 - O10H3_HUMAN

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Protein
Olfactory receptor 10H3
Gene
OR10H3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 10H3
    Alternative name(s):
    Olfactory receptor OR19-24
    Gene namesi
    Name:OR10H3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:8174. OR10H3.

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei26 – 4621Helical; Name=1; Reviewed prediction
    Add
    BLAST
    Topological domaini47 – 548Cytoplasmic Reviewed prediction
    Transmembranei55 – 7521Helical; Name=2; Reviewed prediction
    Add
    BLAST
    Topological domaini76 – 9924Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei100 – 12021Helical; Name=3; Reviewed prediction
    Add
    BLAST
    Topological domaini121 – 13919Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei140 – 16021Helical; Name=4; Reviewed prediction
    Add
    BLAST
    Topological domaini161 – 19737Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei198 – 21821Helical; Name=5; Reviewed prediction
    Add
    BLAST
    Topological domaini219 – 23820Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei239 – 25921Helical; Name=6; Reviewed prediction
    Add
    BLAST
    Topological domaini260 – 27213Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei273 – 29321Helical; Name=7; Reviewed prediction
    Add
    BLAST
    Topological domaini294 – 31623Cytoplasmic Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31979.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 316316Olfactory receptor 10H3
    PRO_0000150704Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi98 ↔ 190 By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiO60404.

    Expressioni

    Gene expression databases

    BgeeiO60404.
    CleanExiHS_OR10H3.
    GenevestigatoriO60404.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000307130.

    Structurei

    3D structure databases

    ProteinModelPortaliO60404.
    SMRiO60404. Positions 31-163.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG79272.
    HOGENOMiHOG000041365.
    HOVERGENiHBG017625.
    InParanoidiO60404.
    KOiK04257.
    OMAiTVWIERR.
    OrthoDBiEOG78PV9F.
    PhylomeDBiO60404.
    TreeFamiTF338279.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O60404-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPGQNYRTIS EFILSGFSAF PQQLLPVLFL LYLLMFLFTL LGNLLIMATV    50
    WIERRLHTPM YLFLCALSIS EILFTVAITP RMLADLLFTH RSITFVACAI 100
    QMFFSFMFGF THSFLLMVMG YDHYVTICHP LHYNMLMSPR GCAHLVAWTW 150
    AGGSVMGMMV TMMVFHLTFC GSNVIHHFLC HVLSLLKLAC GSKTSSVIMG 200
    VMLVCVTALI GCLFLIILSF VFIVAAILRI PSAEGRHKTF STCVSHLTVV 250
    VMHYSFASLI YLKPKGLHSM YSDALMATTY TVFTPFLSPI IFSLRNKELK 300
    NAINKNFCRR FCPLSS 316
    Length:316
    Mass (Da):35,721
    Last modified:August 1, 1998 - v1
    Checksum:iD055291FB9B49BC3
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti7 – 71R → S.
    Corresponds to variant rs1966357 [ dbSNP | Ensembl ].
    VAR_024128
    Natural varianti14 – 141L → I.
    Corresponds to variant rs2240227 [ dbSNP | Ensembl ].
    VAR_034288
    Natural varianti54 – 541R → H.
    Corresponds to variant rs11670007 [ dbSNP | Ensembl ].
    VAR_034289
    Natural varianti224 – 2241V → M.1 Publication
    Corresponds to variant rs2240228 [ dbSNP | Ensembl ].
    VAR_020381
    Natural varianti293 – 2931S → N.
    Corresponds to variant rs2240229 [ dbSNP | Ensembl ].
    VAR_020382

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC004597 Genomic DNA. Translation: AAC14389.1.
    BC106707 mRNA. Translation: AAI06708.1.
    BC113844 mRNA. Translation: AAI13845.1.
    BK004212 Genomic DNA. Translation: DAA04610.1.
    CCDSiCCDS12334.1.
    RefSeqiNP_039226.1. NM_013938.1.
    UniGeneiHs.553524.

    Genome annotation databases

    EnsembliENST00000305892; ENSP00000307130; ENSG00000171936.
    GeneIDi26532.
    KEGGihsa:26532.
    UCSCiuc010xoq.2. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC004597 Genomic DNA. Translation: AAC14389.1 .
    BC106707 mRNA. Translation: AAI06708.1 .
    BC113844 mRNA. Translation: AAI13845.1 .
    BK004212 Genomic DNA. Translation: DAA04610.1 .
    CCDSi CCDS12334.1.
    RefSeqi NP_039226.1. NM_013938.1.
    UniGenei Hs.553524.

    3D structure databases

    ProteinModelPortali O60404.
    SMRi O60404. Positions 31-163.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000307130.

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PRIDEi O60404.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000305892 ; ENSP00000307130 ; ENSG00000171936 .
    GeneIDi 26532.
    KEGGi hsa:26532.
    UCSCi uc010xoq.2. human.

    Organism-specific databases

    CTDi 26532.
    GeneCardsi GC19P015852.
    HGNCi HGNC:8174. OR10H3.
    neXtProti NX_O60404.
    PharmGKBi PA31979.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG79272.
    HOGENOMi HOG000041365.
    HOVERGENi HBG017625.
    InParanoidi O60404.
    KOi K04257.
    OMAi TVWIERR.
    OrthoDBi EOG78PV9F.
    PhylomeDBi O60404.
    TreeFami TF338279.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR10H3.
    GenomeRNAii 26532.
    NextBioi 48880.
    PROi O60404.

    Gene expression databases

    Bgeei O60404.
    CleanExi HS_OR10H3.
    Genevestigatori O60404.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-224.
    3. Cited for: IDENTIFICATION.
    4. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO10H3_HUMAN
    AccessioniPrimary (citable) accession number: O60404
    Secondary accession number(s): Q2HIZ3, Q6IFQ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: August 1, 1998
    Last modified: September 3, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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