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O60404 (O10H3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 10H3
Alternative name(s):
Olfactory receptor OR19-24
Gene names
Name:OR10H3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length316 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 316316Olfactory receptor 10H3
PRO_0000150704

Regions

Topological domain1 – 2525Extracellular Potential
Transmembrane26 – 4621Helical; Name=1; Potential
Topological domain47 – 548Cytoplasmic Potential
Transmembrane55 – 7521Helical; Name=2; Potential
Topological domain76 – 9924Extracellular Potential
Transmembrane100 – 12021Helical; Name=3; Potential
Topological domain121 – 13919Cytoplasmic Potential
Transmembrane140 – 16021Helical; Name=4; Potential
Topological domain161 – 19737Extracellular Potential
Transmembrane198 – 21821Helical; Name=5; Potential
Topological domain219 – 23820Cytoplasmic Potential
Transmembrane239 – 25921Helical; Name=6; Potential
Topological domain260 – 27213Extracellular Potential
Transmembrane273 – 29321Helical; Name=7; Potential
Topological domain294 – 31623Cytoplasmic Potential

Amino acid modifications

Disulfide bond98 ↔ 190 By similarity

Natural variations

Natural variant71R → S.
Corresponds to variant rs1966357 [ dbSNP | Ensembl ].
VAR_024128
Natural variant141L → I.
Corresponds to variant rs2240227 [ dbSNP | Ensembl ].
VAR_034288
Natural variant541R → H.
Corresponds to variant rs11670007 [ dbSNP | Ensembl ].
VAR_034289
Natural variant2241V → M. Ref.2
Corresponds to variant rs2240228 [ dbSNP | Ensembl ].
VAR_020381
Natural variant2931S → N.
Corresponds to variant rs2240229 [ dbSNP | Ensembl ].
VAR_020382

Sequences

Sequence LengthMass (Da)Tools
O60404 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: D055291FB9B49BC3

FASTA31635,721
        10         20         30         40         50         60 
MPGQNYRTIS EFILSGFSAF PQQLLPVLFL LYLLMFLFTL LGNLLIMATV WIERRLHTPM 

        70         80         90        100        110        120 
YLFLCALSIS EILFTVAITP RMLADLLFTH RSITFVACAI QMFFSFMFGF THSFLLMVMG 

       130        140        150        160        170        180 
YDHYVTICHP LHYNMLMSPR GCAHLVAWTW AGGSVMGMMV TMMVFHLTFC GSNVIHHFLC 

       190        200        210        220        230        240 
HVLSLLKLAC GSKTSSVIMG VMLVCVTALI GCLFLIILSF VFIVAAILRI PSAEGRHKTF 

       250        260        270        280        290        300 
STCVSHLTVV VMHYSFASLI YLKPKGLHSM YSDALMATTY TVFTPFLSPI IFSLRNKELK 

       310 
NAINKNFCRR FCPLSS 

« Hide

References

« Hide 'large scale' references
[1]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-224.
[3]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[4]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC004597 Genomic DNA. Translation: AAC14389.1.
BC106707 mRNA. Translation: AAI06708.1.
BC113844 mRNA. Translation: AAI13845.1.
BK004212 Genomic DNA. Translation: DAA04610.1.
CCDSCCDS12334.1.
RefSeqNP_039226.1. NM_013938.1.
UniGeneHs.553524.

3D structure databases

ProteinModelPortalO60404.
SMRO60404. Positions 31-163.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000307130.

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PRIDEO60404.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000305892; ENSP00000307130; ENSG00000171936.
GeneID26532.
KEGGhsa:26532.
UCSCuc010xoq.2. human.

Organism-specific databases

CTD26532.
GeneCardsGC19P015852.
HGNCHGNC:8174. OR10H3.
neXtProtNX_O60404.
PharmGKBPA31979.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG79272.
HOGENOMHOG000041365.
HOVERGENHBG017625.
InParanoidO60404.
KOK04257.
OMATVWIERR.
OrthoDBEOG78PV9F.
PhylomeDBO60404.
TreeFamTF338279.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeO60404.
CleanExHS_OR10H3.
GenevestigatorO60404.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR10H3.
GenomeRNAi26532.
NextBio48880.
PROO60404.

Entry information

Entry nameO10H3_HUMAN
AccessionPrimary (citable) accession number: O60404
Secondary accession number(s): Q2HIZ3, Q6IFQ0
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: August 1, 1998
Last modified: July 9, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries