ID   O10H2_HUMAN             Reviewed;         315 AA.
AC   O60403; Q6IFQ1; Q96R58;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   24-JAN-2024, entry version 176.
DE   RecName: Full=Olfactory receptor 10H2;
DE   AltName: Full=Olfactory receptor OR19-23;
GN   Name=OR10H2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-284.
RX   PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA   Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA   Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA   Lehrach H., Lancet D., Shamir R.;
RT   "DEFOG: a practical scheme for deciphering families of genes.";
RL   Genomics 80:295-302(2002).
RN   [4]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [5]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
RN   [6]
RP   VARIANT HIS-131.
RX   PubMed=23647072; DOI=10.1111/epi.12201;
RA   Veeramah K.R., Johnstone L., Karafet T.M., Wolf D., Sprissler R.,
RA   Salogiannis J., Barth-Maron A., Greenberg M.E., Stuhlmann T., Weinert S.,
RA   Jentsch T.J., Pazzi M., Restifo L.L., Talwar D., Erickson R.P.,
RA   Hammer M.F.;
RT   "Exome sequencing reveals new causal mutations in children with epileptic
RT   encephalopathies.";
RL   Epilepsia 54:1270-1281(2013).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="https://genome.weizmann.ac.il/horde/card/index/symbol:OR10H2/term:OR10H2/type:keyword";
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DR   EMBL; AC004597; AAC14388.1; -; Genomic_DNA.
DR   EMBL; BC069085; AAH69085.1; -; mRNA.
DR   EMBL; BC069457; AAH69457.1; -; mRNA.
DR   EMBL; BC112178; AAI12179.1; -; mRNA.
DR   EMBL; BC113647; AAI13648.1; -; mRNA.
DR   EMBL; AF399585; AAK95070.1; -; Genomic_DNA.
DR   EMBL; BK004211; DAA04609.1; -; Genomic_DNA.
DR   CCDS; CCDS12333.1; -.
DR   RefSeq; NP_039227.1; NM_013939.2.
DR   AlphaFoldDB; O60403; -.
DR   SMR; O60403; -.
DR   BioGRID; 117738; 72.
DR   STRING; 9606.ENSP00000306095; -.
DR   GlyCosmos; O60403; 1 site, No reported glycans.
DR   GlyGen; O60403; 1 site.
DR   BioMuta; OR10H2; -.
DR   MassIVE; O60403; -.
DR   PaxDb; 9606-ENSP00000306095; -.
DR   PeptideAtlas; O60403; -.
DR   Antibodypedia; 57126; 45 antibodies from 16 providers.
DR   DNASU; 26538; -.
DR   Ensembl; ENST00000305899.5; ENSP00000306095.3; ENSG00000171942.5.
DR   GeneID; 26538; -.
DR   KEGG; hsa:26538; -.
DR   MANE-Select; ENST00000305899.5; ENSP00000306095.3; NM_013939.2; NP_039227.1.
DR   UCSC; uc002nbm.3; human.
DR   AGR; HGNC:8173; -.
DR   CTD; 26538; -.
DR   GeneCards; OR10H2; -.
DR   HGNC; HGNC:8173; OR10H2.
DR   HPA; ENSG00000171942; Not detected.
DR   neXtProt; NX_O60403; -.
DR   OpenTargets; ENSG00000171942; -.
DR   PharmGKB; PA31978; -.
DR   VEuPathDB; HostDB:ENSG00000171942; -.
DR   eggNOG; ENOG502SJHK; Eukaryota.
DR   GeneTree; ENSGT01100000263561; -.
DR   HOGENOM; CLU_012526_1_0_1; -.
DR   InParanoid; O60403; -.
DR   OMA; FMSPRAC; -.
DR   OrthoDB; 4514128at2759; -.
DR   PhylomeDB; O60403; -.
DR   TreeFam; TF337675; -.
DR   PathwayCommons; O60403; -.
DR   Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 26538; 13 hits in 709 CRISPR screens.
DR   GeneWiki; OR10H2; -.
DR   GenomeRNAi; 26538; -.
DR   Pharos; O60403; Tdark.
DR   PRO; PR:O60403; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; O60403; Protein.
DR   ExpressionAtlas; O60403; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR   CDD; cd15225; 7tmA_OR10A-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR26453; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR26453:SF712; OLFACTORY RECEPTOR 10H1-RELATED; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   Genevisible; O60403; HS.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..315
FT                   /note="Olfactory receptor 10H2"
FT                   /id="PRO_0000150703"
FT   TOPO_DOM        1..25
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..46
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        47..54
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        76..99
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        121..139
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..160
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        161..197
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        198..218
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        219..238
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..259
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        260..272
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        273..293
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        294..315
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        97..189
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         40
FT                   /note="L -> Q (in dbSNP:rs4569397)"
FT                   /id="VAR_062062"
FT   VARIANT         131
FT                   /note="R -> H (found in a child with sporadic epilepsy;
FT                   uncertain significance; dbSNP:rs756001079)"
FT                   /evidence="ECO:0000269|PubMed:23647072"
FT                   /id="VAR_077833"
FT   VARIANT         171
FT                   /note="S -> F (in dbSNP:rs1806931)"
FT                   /id="VAR_022049"
SQ   SEQUENCE   315 AA;  34663 MW;  C68387742D3B9382 CRC64;
     MLGLNHTSMS EFILVGFSAF PHLQLMLFLL FLLMYLFTLL GNLLIMATVW SERSLHTPMY
     LFLCVLSVSE ILYTVAIIPR MLADLLSTQR SIAFLACASQ MFFSFSFGFT HSFLLTVMGY
     DRYVAICHPL RYNVLMSPRG CACLVGCSWA GGSVMGMVVT SAIFQLTFCG SHEIQHFLCH
     VPPLLKLACG NNVPAVALGV GLVCIMALLG CFLLILLSYA FIVADILKIP SAEGRNKAFS
     TCASHLIVVI VHYGFASVIY LKPKGPHSQE GDTLMATTYA VLTPFLSPII FSLRNKELKV
     AMKRTFLSTL YSSGT
//