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O60403

- O10H2_HUMAN

UniProt

O60403 - O10H2_HUMAN

Protein

Olfactory receptor 10H2

Gene

OR10H2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 10H2
    Alternative name(s):
    Olfactory receptor OR19-23
    Gene namesi
    Name:OR10H2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:8173. OR10H2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31978.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 315315Olfactory receptor 10H2PRO_0000150703Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO60403.
    PRIDEiO60403.

    Expressioni

    Gene expression databases

    CleanExiHS_OR10H2.
    GenevestigatoriO60403.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000306095.

    Structurei

    3D structure databases

    ProteinModelPortaliO60403.
    SMRiO60403. Positions 23-218.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini47 – 548CytoplasmicSequence Analysis
    Topological domaini76 – 9924ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini161 – 19737ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini219 – 23820CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini260 – 27213ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini294 – 31522CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei55 – 7521Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei198 – 21821Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei239 – 25921Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei273 – 29321Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG79272.
    HOGENOMiHOG000041364.
    HOVERGENiHBG017625.
    InParanoidiO60403.
    KOiK04257.
    OMAiGPHSQEG.
    OrthoDBiEOG78PV9F.
    PhylomeDBiO60403.
    TreeFamiTF337675.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR019424. 7TM_GPCR_olfarory/Srsx.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PfamiPF10320. 7TM_GPCR_Srsx. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O60403-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLGLNHTSMS EFILVGFSAF PHLQLMLFLL FLLMYLFTLL GNLLIMATVW    50
    SERSLHTPMY LFLCVLSVSE ILYTVAIIPR MLADLLSTQR SIAFLACASQ 100
    MFFSFSFGFT HSFLLTVMGY DRYVAICHPL RYNVLMSPRG CACLVGCSWA 150
    GGSVMGMVVT SAIFQLTFCG SHEIQHFLCH VPPLLKLACG NNVPAVALGV 200
    GLVCIMALLG CFLLILLSYA FIVADILKIP SAEGRNKAFS TCASHLIVVI 250
    VHYGFASVIY LKPKGPHSQE GDTLMATTYA VLTPFLSPII FSLRNKELKV 300
    AMKRTFLSTL YSSGT 315
    Length:315
    Mass (Da):34,663
    Last modified:August 1, 1998 - v1
    Checksum:iC68387742D3B9382
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti40 – 401L → Q.
    Corresponds to variant rs4569397 [ dbSNP | Ensembl ].
    VAR_062062
    Natural varianti171 – 1711S → F.
    Corresponds to variant rs1806931 [ dbSNP | Ensembl ].
    VAR_022049

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC004597 Genomic DNA. Translation: AAC14388.1.
    BC069085 mRNA. Translation: AAH69085.1.
    BC069457 mRNA. Translation: AAH69457.1.
    BC112178 mRNA. Translation: AAI12179.1.
    BC113647 mRNA. Translation: AAI13648.1.
    AF399585 Genomic DNA. Translation: AAK95070.1.
    BK004211 Genomic DNA. Translation: DAA04609.1.
    CCDSiCCDS12333.1.
    RefSeqiNP_039227.1. NM_013939.2.
    UniGeneiHs.247694.

    Genome annotation databases

    EnsembliENST00000305899; ENSP00000306095; ENSG00000171942.
    GeneIDi26538.
    KEGGihsa:26538.
    UCSCiuc002nbm.2. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC004597 Genomic DNA. Translation: AAC14388.1 .
    BC069085 mRNA. Translation: AAH69085.1 .
    BC069457 mRNA. Translation: AAH69457.1 .
    BC112178 mRNA. Translation: AAI12179.1 .
    BC113647 mRNA. Translation: AAI13648.1 .
    AF399585 Genomic DNA. Translation: AAK95070.1 .
    BK004211 Genomic DNA. Translation: DAA04609.1 .
    CCDSi CCDS12333.1.
    RefSeqi NP_039227.1. NM_013939.2.
    UniGenei Hs.247694.

    3D structure databases

    ProteinModelPortali O60403.
    SMRi O60403. Positions 23-218.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000306095.

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PaxDbi O60403.
    PRIDEi O60403.

    Protocols and materials databases

    DNASUi 26538.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000305899 ; ENSP00000306095 ; ENSG00000171942 .
    GeneIDi 26538.
    KEGGi hsa:26538.
    UCSCi uc002nbm.2. human.

    Organism-specific databases

    CTDi 26538.
    GeneCardsi GC19P015838.
    HGNCi HGNC:8173. OR10H2.
    neXtProti NX_O60403.
    PharmGKBi PA31978.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG79272.
    HOGENOMi HOG000041364.
    HOVERGENi HBG017625.
    InParanoidi O60403.
    KOi K04257.
    OMAi GPHSQEG.
    OrthoDBi EOG78PV9F.
    PhylomeDBi O60403.
    TreeFami TF337675.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR10H2.
    GenomeRNAii 26538.
    NextBioi 48894.
    PROi O60403.

    Gene expression databases

    CleanExi HS_OR10H2.
    Genevestigatori O60403.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR019424. 7TM_GPCR_olfarory/Srsx.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    Pfami PF10320. 7TM_GPCR_Srsx. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-284.
    4. Cited for: IDENTIFICATION.
    5. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO10H2_HUMAN
    AccessioniPrimary (citable) accession number: O60403
    Secondary accession number(s): Q6IFQ1, Q96R58
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3