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O60403

- O10H2_HUMAN

UniProt

O60403 - O10H2_HUMAN

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Protein

Olfactory receptor 10H2

Gene
OR10H2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10H2
Alternative name(s):
Olfactory receptor OR19-23
Gene namesi
Name:OR10H2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:8173. OR10H2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525Extracellular Reviewed predictionAdd
BLAST
Transmembranei26 – 4621Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini47 – 548Cytoplasmic Reviewed prediction
Transmembranei55 – 7521Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini76 – 9924Extracellular Reviewed predictionAdd
BLAST
Transmembranei100 – 12021Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini121 – 13919Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei140 – 16021Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini161 – 19737Extracellular Reviewed predictionAdd
BLAST
Transmembranei198 – 21821Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini219 – 23820Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei239 – 25921Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini260 – 27213Extracellular Reviewed predictionAdd
BLAST
Transmembranei273 – 29321Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini294 – 31522Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31978.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 315315Olfactory receptor 10H2PRO_0000150703Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi97 ↔ 189 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO60403.
PRIDEiO60403.

Expressioni

Gene expression databases

CleanExiHS_OR10H2.
GenevestigatoriO60403.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000306095.

Structurei

3D structure databases

ProteinModelPortaliO60403.
SMRiO60403. Positions 23-218.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG79272.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiO60403.
KOiK04257.
OMAiGPHSQEG.
OrthoDBiEOG78PV9F.
PhylomeDBiO60403.
TreeFamiTF337675.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR019424. 7TM_GPCR_olfarory/Srsx.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PfamiPF10320. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O60403-1 [UniParc]FASTAAdd to Basket

« Hide

MLGLNHTSMS EFILVGFSAF PHLQLMLFLL FLLMYLFTLL GNLLIMATVW    50
SERSLHTPMY LFLCVLSVSE ILYTVAIIPR MLADLLSTQR SIAFLACASQ 100
MFFSFSFGFT HSFLLTVMGY DRYVAICHPL RYNVLMSPRG CACLVGCSWA 150
GGSVMGMVVT SAIFQLTFCG SHEIQHFLCH VPPLLKLACG NNVPAVALGV 200
GLVCIMALLG CFLLILLSYA FIVADILKIP SAEGRNKAFS TCASHLIVVI 250
VHYGFASVIY LKPKGPHSQE GDTLMATTYA VLTPFLSPII FSLRNKELKV 300
AMKRTFLSTL YSSGT 315
Length:315
Mass (Da):34,663
Last modified:August 1, 1998 - v1
Checksum:iC68387742D3B9382
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti40 – 401L → Q.
Corresponds to variant rs4569397 [ dbSNP | Ensembl ].
VAR_062062
Natural varianti171 – 1711S → F.
Corresponds to variant rs1806931 [ dbSNP | Ensembl ].
VAR_022049

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC004597 Genomic DNA. Translation: AAC14388.1.
BC069085 mRNA. Translation: AAH69085.1.
BC069457 mRNA. Translation: AAH69457.1.
BC112178 mRNA. Translation: AAI12179.1.
BC113647 mRNA. Translation: AAI13648.1.
AF399585 Genomic DNA. Translation: AAK95070.1.
BK004211 Genomic DNA. Translation: DAA04609.1.
CCDSiCCDS12333.1.
RefSeqiNP_039227.1. NM_013939.2.
UniGeneiHs.247694.

Genome annotation databases

EnsembliENST00000305899; ENSP00000306095; ENSG00000171942.
GeneIDi26538.
KEGGihsa:26538.
UCSCiuc002nbm.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC004597 Genomic DNA. Translation: AAC14388.1 .
BC069085 mRNA. Translation: AAH69085.1 .
BC069457 mRNA. Translation: AAH69457.1 .
BC112178 mRNA. Translation: AAI12179.1 .
BC113647 mRNA. Translation: AAI13648.1 .
AF399585 Genomic DNA. Translation: AAK95070.1 .
BK004211 Genomic DNA. Translation: DAA04609.1 .
CCDSi CCDS12333.1.
RefSeqi NP_039227.1. NM_013939.2.
UniGenei Hs.247694.

3D structure databases

ProteinModelPortali O60403.
SMRi O60403. Positions 23-218.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000306095.

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PaxDbi O60403.
PRIDEi O60403.

Protocols and materials databases

DNASUi 26538.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000305899 ; ENSP00000306095 ; ENSG00000171942 .
GeneIDi 26538.
KEGGi hsa:26538.
UCSCi uc002nbm.2. human.

Organism-specific databases

CTDi 26538.
GeneCardsi GC19P015838.
HGNCi HGNC:8173. OR10H2.
neXtProti NX_O60403.
PharmGKBi PA31978.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG79272.
HOGENOMi HOG000041364.
HOVERGENi HBG017625.
InParanoidi O60403.
KOi K04257.
OMAi GPHSQEG.
OrthoDBi EOG78PV9F.
PhylomeDBi O60403.
TreeFami TF337675.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR10H2.
GenomeRNAii 26538.
NextBioi 48894.
PROi O60403.

Gene expression databases

CleanExi HS_OR10H2.
Genevestigatori O60403.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR019424. 7TM_GPCR_olfarory/Srsx.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
Pfami PF10320. 7TM_GPCR_Srsx. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-284.
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO10H2_HUMAN
AccessioniPrimary (citable) accession number: O60403
Secondary accession number(s): Q6IFQ1, Q96R58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: August 1, 1998
Last modified: September 3, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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