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Protein

Olfactory receptor 10H2

Gene

OR10H2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10H2
Alternative name(s):
Olfactory receptor OR19-23
Gene namesi
Name:OR10H2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:8173. OR10H2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini47 – 548CytoplasmicSequence Analysis
Transmembranei55 – 7521Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini76 – 9924ExtracellularSequence AnalysisAdd
BLAST
Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini161 – 19737ExtracellularSequence AnalysisAdd
BLAST
Transmembranei198 – 21821Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini219 – 23820CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei239 – 25921Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini260 – 27213ExtracellularSequence AnalysisAdd
BLAST
Transmembranei273 – 29321Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini294 – 31522CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31978.

Polymorphism and mutation databases

BioMutaiOR10H2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 315315Olfactory receptor 10H2PRO_0000150703Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO60403.
PRIDEiO60403.

Expressioni

Gene expression databases

CleanExiHS_OR10H2.
GenevestigatoriO60403.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000306095.

Structurei

3D structure databases

ProteinModelPortaliO60403.
SMRiO60403. Positions 23-218.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG79272.
GeneTreeiENSGT00760000119043.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiO60403.
KOiK04257.
OMAiGPHSQEG.
OrthoDBiEOG78PV9F.
PhylomeDBiO60403.
TreeFamiTF337675.

Family and domain databases

InterProiIPR019424. 7TM_GPCR_olfarory/Srsx.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PfamiPF10320. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O60403-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGLNHTSMS EFILVGFSAF PHLQLMLFLL FLLMYLFTLL GNLLIMATVW
60 70 80 90 100
SERSLHTPMY LFLCVLSVSE ILYTVAIIPR MLADLLSTQR SIAFLACASQ
110 120 130 140 150
MFFSFSFGFT HSFLLTVMGY DRYVAICHPL RYNVLMSPRG CACLVGCSWA
160 170 180 190 200
GGSVMGMVVT SAIFQLTFCG SHEIQHFLCH VPPLLKLACG NNVPAVALGV
210 220 230 240 250
GLVCIMALLG CFLLILLSYA FIVADILKIP SAEGRNKAFS TCASHLIVVI
260 270 280 290 300
VHYGFASVIY LKPKGPHSQE GDTLMATTYA VLTPFLSPII FSLRNKELKV
310
AMKRTFLSTL YSSGT
Length:315
Mass (Da):34,663
Last modified:August 1, 1998 - v1
Checksum:iC68387742D3B9382
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti40 – 401L → Q.
Corresponds to variant rs4569397 [ dbSNP | Ensembl ].
VAR_062062
Natural varianti171 – 1711S → F.
Corresponds to variant rs1806931 [ dbSNP | Ensembl ].
VAR_022049

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004597 Genomic DNA. Translation: AAC14388.1.
BC069085 mRNA. Translation: AAH69085.1.
BC069457 mRNA. Translation: AAH69457.1.
BC112178 mRNA. Translation: AAI12179.1.
BC113647 mRNA. Translation: AAI13648.1.
AF399585 Genomic DNA. Translation: AAK95070.1.
BK004211 Genomic DNA. Translation: DAA04609.1.
CCDSiCCDS12333.1.
RefSeqiNP_039227.1. NM_013939.2.
UniGeneiHs.247694.

Genome annotation databases

EnsembliENST00000305899; ENSP00000306095; ENSG00000171942.
GeneIDi26538.
KEGGihsa:26538.
UCSCiuc002nbm.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004597 Genomic DNA. Translation: AAC14388.1.
BC069085 mRNA. Translation: AAH69085.1.
BC069457 mRNA. Translation: AAH69457.1.
BC112178 mRNA. Translation: AAI12179.1.
BC113647 mRNA. Translation: AAI13648.1.
AF399585 Genomic DNA. Translation: AAK95070.1.
BK004211 Genomic DNA. Translation: DAA04609.1.
CCDSiCCDS12333.1.
RefSeqiNP_039227.1. NM_013939.2.
UniGeneiHs.247694.

3D structure databases

ProteinModelPortaliO60403.
SMRiO60403. Positions 23-218.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000306095.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR10H2.

Proteomic databases

PaxDbiO60403.
PRIDEiO60403.

Protocols and materials databases

DNASUi26538.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305899; ENSP00000306095; ENSG00000171942.
GeneIDi26538.
KEGGihsa:26538.
UCSCiuc002nbm.2. human.

Organism-specific databases

CTDi26538.
GeneCardsiGC19P015838.
HGNCiHGNC:8173. OR10H2.
neXtProtiNX_O60403.
PharmGKBiPA31978.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG79272.
GeneTreeiENSGT00760000119043.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiO60403.
KOiK04257.
OMAiGPHSQEG.
OrthoDBiEOG78PV9F.
PhylomeDBiO60403.
TreeFamiTF337675.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR10H2.
GenomeRNAii26538.
NextBioi48894.
PROiO60403.

Gene expression databases

CleanExiHS_OR10H2.
GenevestigatoriO60403.

Family and domain databases

InterProiIPR019424. 7TM_GPCR_olfarory/Srsx.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PfamiPF10320. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-284.
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO10H2_HUMAN
AccessioniPrimary (citable) accession number: O60403
Secondary accession number(s): Q6IFQ1, Q96R58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: August 1, 1998
Last modified: April 29, 2015
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.