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O60403 (O10H2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 10H2
Alternative name(s):
Olfactory receptor OR19-23
Gene names
Name:OR10H2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length315 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 315315Olfactory receptor 10H2
PRO_0000150703

Regions

Topological domain1 – 2525Extracellular Potential
Transmembrane26 – 4621Helical; Name=1; Potential
Topological domain47 – 548Cytoplasmic Potential
Transmembrane55 – 7521Helical; Name=2; Potential
Topological domain76 – 9924Extracellular Potential
Transmembrane100 – 12021Helical; Name=3; Potential
Topological domain121 – 13919Cytoplasmic Potential
Transmembrane140 – 16021Helical; Name=4; Potential
Topological domain161 – 19737Extracellular Potential
Transmembrane198 – 21821Helical; Name=5; Potential
Topological domain219 – 23820Cytoplasmic Potential
Transmembrane239 – 25921Helical; Name=6; Potential
Topological domain260 – 27213Extracellular Potential
Transmembrane273 – 29321Helical; Name=7; Potential
Topological domain294 – 31522Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Disulfide bond97 ↔ 189 By similarity

Natural variations

Natural variant401L → Q.
Corresponds to variant rs4569397 [ dbSNP | Ensembl ].
VAR_062062
Natural variant1711S → F.
Corresponds to variant rs1806931 [ dbSNP | Ensembl ].
VAR_022049

Sequences

Sequence LengthMass (Da)Tools
O60403 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: C68387742D3B9382

FASTA31534,663
        10         20         30         40         50         60 
MLGLNHTSMS EFILVGFSAF PHLQLMLFLL FLLMYLFTLL GNLLIMATVW SERSLHTPMY 

        70         80         90        100        110        120 
LFLCVLSVSE ILYTVAIIPR MLADLLSTQR SIAFLACASQ MFFSFSFGFT HSFLLTVMGY 

       130        140        150        160        170        180 
DRYVAICHPL RYNVLMSPRG CACLVGCSWA GGSVMGMVVT SAIFQLTFCG SHEIQHFLCH 

       190        200        210        220        230        240 
VPPLLKLACG NNVPAVALGV GLVCIMALLG CFLLILLSYA FIVADILKIP SAEGRNKAFS 

       250        260        270        280        290        300 
TCASHLIVVI VHYGFASVIY LKPKGPHSQE GDTLMATTYA VLTPFLSPII FSLRNKELKV 

       310 
AMKRTFLSTL YSSGT

« Hide

References

« Hide 'large scale' references
[1]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"DEFOG: a practical scheme for deciphering families of genes."
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R.
Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-284.
[4]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[5]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AC004597 Genomic DNA. Translation: AAC14388.1.
BC069085 mRNA. Translation: AAH69085.1.
BC069457 mRNA. Translation: AAH69457.1.
BC112178 mRNA. Translation: AAI12179.1.
BC113647 mRNA. Translation: AAI13648.1.
AF399585 Genomic DNA. Translation: AAK95070.1.
BK004211 Genomic DNA. Translation: DAA04609.1.
IPIIPI00029535.
RefSeqNP_039227.1. NM_013939.2.
UniGeneHs.247694.

3D structure databases

ProteinModelPortalO60403.
ModBaseSearch...

Protein-protein interaction databases

STRING9606.ENSP00000306095.

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PaxDbO60403.
PRIDEO60403.

Protocols and materials databases

DNASU26538.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000305899; ENSP00000306095; ENSG00000171942.
GeneID26538.
KEGGhsa:26538.
UCSCuc002nbm.2. human.

Organism-specific databases

CTD26538.
GeneCardsGC19P015838.
HGNCHGNC:8173. OR10H2.
neXtProtNX_O60403.
PharmGKBPA31978.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG79272.
HOGENOMHOG000041364.
HOVERGENHBG017625.
InParanoidO60403.
KOK04257.
OMAYAFIVAD.
OrthoDBEOG42V8H0.
PhylomeDBO60403.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR10H2.
GenevestigatorO60403.
GermOnlineENSG00000171942. Homo sapiens.

Family and domain databases

InterProIPR019424. 7TM_GPCR_olfarory/Srsx.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PfamPF10320. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. False negative.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi26538.
NextBio48894.

Entry information

Entry nameO10H2_HUMAN
AccessionPrimary (citable) accession number: O60403
Secondary accession number(s): Q6IFQ1, Q96R58
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: August 1, 1998
Last modified: May 1, 2013
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents