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Protein

Glutamate receptor ionotropic, NMDA 3B

Gene

GRIN3B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine.

GO - Molecular functioni

  1. calcium channel activity Source: Ensembl
  2. cation channel activity Source: UniProtKB
  3. extracellular-glutamate-gated ion channel activity Source: GO_Central
  4. glycine binding Source: UniProtKB
  5. neurotransmitter binding Source: UniProtKB
  6. neurotransmitter receptor activity Source: UniProtKB
  7. N-methyl-D-aspartate selective glutamate receptor activity Source: GO_Central

GO - Biological processi

  1. ionotropic glutamate receptor signaling pathway Source: UniProtKB
  2. ion transmembrane transport Source: GO_Central
  3. protein insertion into membrane Source: UniProtKB
  4. regulation of calcium ion transport Source: UniProtKB
  5. synaptic transmission, glutamatergic Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Calcium, Magnesium

Enzyme and pathway databases

SignaLinkiO60391.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate receptor ionotropic, NMDA 3B
Short name:
GluN3B
Alternative name(s):
N-methyl-D-aspartate receptor subtype 3B
Short name:
NMDAR3B
Short name:
NR3B
Gene namesi
Name:GRIN3B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:16768. GRIN3B.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity. Cell junctionsynapsepostsynaptic cell membrane By similarity
Note: Requires the presence of GRIN1 to be targeted at the plasma membrane.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 564542ExtracellularSequence AnalysisAdd
BLAST
Transmembranei565 – 58521HelicalSequence AnalysisAdd
BLAST
Topological domaini586 – 64863CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei649 – 66921HelicalSequence AnalysisAdd
BLAST
Topological domaini670 – 830161ExtracellularSequence AnalysisAdd
BLAST
Transmembranei831 – 85121HelicalSequence AnalysisAdd
BLAST
Topological domaini852 – 1043192CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. dendrite Source: GO_Central
  3. neuronal cell body Source: UniProtKB
  4. N-methyl-D-aspartate selective glutamate receptor complex Source: UniProtKB
  5. postsynaptic membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28984.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 10431021Glutamate receptor ionotropic, NMDA 3BPRO_0000011570Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi69 – 691N-linked (GlcNAc...)Sequence Analysis
Glycosylationi344 – 3441N-linked (GlcNAc...)Sequence Analysis
Glycosylationi451 – 4511N-linked (GlcNAc...)Sequence Analysis
Glycosylationi465 – 4651N-linked (GlcNAc...)Sequence Analysis
Glycosylationi786 – 7861N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO60391.
PRIDEiO60391.

PTM databases

PhosphoSiteiO60391.

Expressioni

Gene expression databases

BgeeiO60391.
CleanExiHS_GRIN3B.
GenevestigatoriO60391.

Interactioni

Subunit structurei

Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Does not form functional homomeric channels. Found in a complex containing GRIN1 and GRIN2A (By similarity).By similarity

Protein-protein interaction databases

BioGridi125509. 2 interactions.
MINTiMINT-6630966.
STRINGi9606.ENSP00000234389.

Structurei

3D structure databases

SMRiO60391. Positions 66-857.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG320645.
GeneTreeiENSGT00760000119186.
HOGENOMiHOG000231528.
HOVERGENiHBG052634.
InParanoidiO60391.
KOiK05214.
OMAiHLQLDWA.
OrthoDBiEOG7QK0B4.
PhylomeDBiO60391.
TreeFamiTF314731.

Family and domain databases

InterProiIPR019594. Glu/Gly-bd.
IPR001508. Iono_rcpt_met.
IPR001320. Iontro_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00060. Lig_chan. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O60391-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFVRALWLG LALALGPGSA GGHPQPCGVL ARLGGSVRLG ALLPRAPLAR
60 70 80 90 100
ARARAALARA ALAPRLPHNL SLELVVAAPP ARDPASLTRG LCQALVPPGV
110 120 130 140 150
AALLAFPEAR PELLQLHFLA AATETPVLSL LRREARAPLG APNPFHLQLH
160 170 180 190 200
WASPLETLLD VLVAVLQAHA WEDVGLALCR TQDPGGLVAL WTSRAGRPPQ
210 220 230 240 250
LVLDLSRRDT GDAGLRARLA PMAAPVGGEA PVPAAVLLGC DIARARRVLE
260 270 280 290 300
AVPPGPHWLL GTPLPPKALP TAGLPPGLLA LGEVARPPLE AAIHDIVQLV
310 320 330 340 350
ARALGSAAQV QPKRALLPAP VNCGDLQPAG PESPGRFLAR FLANTSFQGR
360 370 380 390 400
TGPVWVTGSS QVHMSRHFKV WSLRRDPRGA PAWATVGSWR DGQLDLEPGG
410 420 430 440 450
ASARPPPPQG AQVWPKLRVV TLLEHPFVFA RDPDEDGQCP AGQLCLDPGT
460 470 480 490 500
NDSATLDALF AALANGSAPR ALRKCCYGYC IDLLERLAED TPFDFELYLV
510 520 530 540 550
GDGKYGALRD GRWTGLVGDL LAGRAHMAVT SFSINSARSQ VVDFTSPFFS
560 570 580 590 600
TSLGIMVRAR DTASPIGAFM WPLHWSTWLG VFAALHLTAL FLTVYEWRSP
610 620 630 640 650
YGLTPRGRNR STVFSYSSAL NLCYAILFRR TVSSKTPKCP TGRLLMNLWA
660 670 680 690 700
IFCLLVLSSY TANLAAVMVG DKTFEELSGI HDPKLHHPAQ GFRFGTVWES
710 720 730 740 750
SAEAYIKKSF PDMHAHMRRH SAPTTPRGVA MLTSDPPKLN AFIMDKSLLD
760 770 780 790 800
YEVSIDADCK LLTVGKPFAI EGYGIGLPQN SPLTSNLSEF ISRYKSSGFI
810 820 830 840 850
DLLHDKWYKM VPCGKRVFAV TETLQMSIYH FAGLFVLLCL GLGSALLSSL
860 870 880 890 900
GEHAFFRLAL PRIRKGSRLQ YWLHTSQKIH RALNTEPPEG SKEETAEAEP
910 920 930 940 950
SGPEVEQQQQ QQDQPTAPEG WKRARRAVDK ERRVRFLLEP AVVVAPEADA
960 970 980 990 1000
EAEAAPREGP VWLCSYGRPP AARPTGAPQP GELQELERRI EVARERLRQA
1010 1020 1030 1040
LVRRGQLLAQ LGDSARHRPR RLLQARAAPA EAPPHSGRPG SQE
Length:1,043
Mass (Da):112,992
Last modified:July 18, 2005 - v2
Checksum:iB7DEB2BEECD6AFEC
GO

Sequence cautioni

The sequence AAC12680.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti157 – 1571T → M.
Corresponds to variant rs2240154 [ dbSNP | Ensembl ].
VAR_019676
Natural varianti404 – 4041R → W.
Corresponds to variant rs4807399 [ dbSNP | Ensembl ].
VAR_019677
Natural varianti414 – 4141W → R.
Corresponds to variant rs2240157 [ dbSNP | Ensembl ].
VAR_019678
Natural varianti577 – 5771T → M.
Corresponds to variant rs2240158 [ dbSNP | Ensembl ].
VAR_019679
Natural varianti612 – 6121T → A.
Corresponds to variant rs60621387 [ dbSNP | Ensembl ].
VAR_061188
Natural varianti845 – 8451A → T.
Corresponds to variant rs2285906 [ dbSNP | Ensembl ].
VAR_019680

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004528 Genomic DNA. Translation: AAC12680.1. Sequence problems.
BK000070 mRNA. Translation: DAA00018.1.
BK004079 mRNA. Translation: DAA04570.1.
CCDSiCCDS32861.1.
RefSeqiNP_619635.1. NM_138690.1.
UniGeneiHs.660378.

Genome annotation databases

EnsembliENST00000234389; ENSP00000234389; ENSG00000116032.
GeneIDi116444.
KEGGihsa:116444.
UCSCiuc002lqo.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004528 Genomic DNA. Translation: AAC12680.1. Sequence problems.
BK000070 mRNA. Translation: DAA00018.1.
BK004079 mRNA. Translation: DAA04570.1.
CCDSiCCDS32861.1.
RefSeqiNP_619635.1. NM_138690.1.
UniGeneiHs.660378.

3D structure databases

SMRiO60391. Positions 66-857.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125509. 2 interactions.
MINTiMINT-6630966.
STRINGi9606.ENSP00000234389.

Chemistry

ChEMBLiCHEMBL2094124.
DrugBankiDB00659. Acamprosate.
DB00289. Atomoxetine.
DB00996. Gabapentin.
DB00145. Glycine.
DB01159. Halothane.
DB06738. Ketobemidone.
DB04896. Milnacipran.
DB01173. Orphenadrine.
DB00312. Pentobarbital.
DB01174. Phenobarbital.
DB00418. Secobarbital.
GuidetoPHARMACOLOGYi461.

PTM databases

PhosphoSiteiO60391.

Proteomic databases

PaxDbiO60391.
PRIDEiO60391.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000234389; ENSP00000234389; ENSG00000116032.
GeneIDi116444.
KEGGihsa:116444.
UCSCiuc002lqo.1. human.

Organism-specific databases

CTDi116444.
GeneCardsiGC19P001000.
HGNCiHGNC:16768. GRIN3B.
MIMi606651. gene.
neXtProtiNX_O60391.
PharmGKBiPA28984.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG320645.
GeneTreeiENSGT00760000119186.
HOGENOMiHOG000231528.
HOVERGENiHBG052634.
InParanoidiO60391.
KOiK05214.
OMAiHLQLDWA.
OrthoDBiEOG7QK0B4.
PhylomeDBiO60391.
TreeFamiTF314731.

Enzyme and pathway databases

SignaLinkiO60391.

Miscellaneous databases

GeneWikiiGRIN3B.
GenomeRNAii116444.
NextBioi79923.
PROiO60391.
SOURCEiSearch...

Gene expression databases

BgeeiO60391.
CleanExiHS_GRIN3B.
GenevestigatoriO60391.

Family and domain databases

InterProiIPR019594. Glu/Gly-bd.
IPR001508. Iono_rcpt_met.
IPR001320. Iontro_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00060. Lig_chan. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Nucleotide sequence, genomic organization, and chromosomal localization of genes encoding the human NMDA receptor subunits NR3A and NR3B."
    Andersson O., Stenqvist A., Attersand A., von Euler G.
    Genomics 78:178-184(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  3. "Motoneuron-specific expression of NR3B, a novel NMDA-type glutamate receptor subunit that works in a dominant-negative manner."
    Nishi M., Hinds H., Lu H.-P., Kawata M., Hayashi Y.
    J. Neurosci. 21:RC185.1-RC185.6(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  4. "Cloning and expression of the human NMDA receptor subunit NR3B in the adult human hippocampus."
    Bendel O., Meijer B., Hurd Y., von Euler G.
    Neurosci. Lett. 377:31-36(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiNMD3B_HUMAN
AccessioniPrimary (citable) accession number: O60391
Secondary accession number(s): Q5EAK7, Q7RTW9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2004
Last sequence update: July 18, 2005
Last modified: March 31, 2015
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.