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O60391 (NMD3B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutamate receptor ionotropic, NMDA 3B

Short name=GluN3B
Alternative name(s):
N-methyl-D-aspartate receptor subtype 3B
Short name=NMDAR3B
Short name=NR3B
Gene names
Name:GRIN3B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1043 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine.

Subunit structure

Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Does not form functional homomeric channels. Found in a complex containing GRIN1 and GRIN2A By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity. Cell junctionsynapsepostsynaptic cell membrane By similarity. Note: Requires the presence of GRIN1 to be targeted at the plasma membrane By similarity.

Sequence similarities

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR3B/GRIN3B subfamily. [View classification]

Sequence caution

The sequence AAC12680.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Biological processIon transport
Transport
   Cellular componentCell junction
Cell membrane
Membrane
Postsynaptic cell membrane
Synapse
   Coding sequence diversityPolymorphism
   DomainSignal
Transmembrane
Transmembrane helix
   LigandCalcium
Magnesium
   Molecular functionIon channel
Ligand-gated ion channel
Receptor
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_procession transmembrane transport

Inferred from Biological aspect of Ancestor. Source: RefGenome

ionotropic glutamate receptor signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

protein insertion into membrane

Inferred from sequence or structural similarity Ref.2. Source: UniProtKB

regulation of calcium ion transport

Inferred from sequence or structural similarity Ref.2. Source: UniProtKB

synaptic transmission, glutamatergic

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Cellular_componentN-methyl-D-aspartate selective glutamate receptor complex

Inferred from sequence or structural similarity Ref.2. Source: UniProtKB

cell junction

Inferred from electronic annotation. Source: UniProtKB-KW

dendrite

Inferred from Biological aspect of Ancestor. Source: RefGenome

neuronal cell body

Inferred from sequence or structural similarity Ref.2. Source: UniProtKB

postsynaptic membrane

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functionN-methyl-D-aspartate selective glutamate receptor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

calcium channel activity

Inferred from electronic annotation. Source: Ensembl

cation channel activity

Inferred from sequence or structural similarity. Source: UniProtKB

extracellular-glutamate-gated ion channel activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

glycine binding

Inferred from sequence or structural similarity. Source: UniProtKB

neurotransmitter binding

Inferred from sequence or structural similarity. Source: UniProtKB

neurotransmitter receptor activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 10431021Glutamate receptor ionotropic, NMDA 3B
PRO_0000011570

Regions

Topological domain23 – 564542Extracellular Potential
Transmembrane565 – 58521Helical; Potential
Topological domain586 – 64863Cytoplasmic Potential
Transmembrane649 – 66921Helical; Potential
Topological domain670 – 830161Extracellular Potential
Transmembrane831 – 85121Helical; Potential
Topological domain852 – 1043192Cytoplasmic Potential

Amino acid modifications

Glycosylation691N-linked (GlcNAc...) Potential
Glycosylation3441N-linked (GlcNAc...) Potential
Glycosylation4511N-linked (GlcNAc...) Potential
Glycosylation4651N-linked (GlcNAc...) Potential
Glycosylation7861N-linked (GlcNAc...) Potential

Natural variations

Natural variant1571T → M.
Corresponds to variant rs2240154 [ dbSNP | Ensembl ].
VAR_019676
Natural variant4041R → W.
Corresponds to variant rs4807399 [ dbSNP | Ensembl ].
VAR_019677
Natural variant4141W → R.
Corresponds to variant rs2240157 [ dbSNP | Ensembl ].
VAR_019678
Natural variant5771T → M.
Corresponds to variant rs2240158 [ dbSNP | Ensembl ].
VAR_019679
Natural variant6121T → A.
Corresponds to variant rs60621387 [ dbSNP | Ensembl ].
VAR_061188
Natural variant8451A → T.
Corresponds to variant rs2285906 [ dbSNP | Ensembl ].
VAR_019680

Sequences

Sequence LengthMass (Da)Tools
O60391 [UniParc].

Last modified July 19, 2005. Version 2.
Checksum: B7DEB2BEECD6AFEC

FASTA1,043112,992
        10         20         30         40         50         60 
MEFVRALWLG LALALGPGSA GGHPQPCGVL ARLGGSVRLG ALLPRAPLAR ARARAALARA 

        70         80         90        100        110        120 
ALAPRLPHNL SLELVVAAPP ARDPASLTRG LCQALVPPGV AALLAFPEAR PELLQLHFLA 

       130        140        150        160        170        180 
AATETPVLSL LRREARAPLG APNPFHLQLH WASPLETLLD VLVAVLQAHA WEDVGLALCR 

       190        200        210        220        230        240 
TQDPGGLVAL WTSRAGRPPQ LVLDLSRRDT GDAGLRARLA PMAAPVGGEA PVPAAVLLGC 

       250        260        270        280        290        300 
DIARARRVLE AVPPGPHWLL GTPLPPKALP TAGLPPGLLA LGEVARPPLE AAIHDIVQLV 

       310        320        330        340        350        360 
ARALGSAAQV QPKRALLPAP VNCGDLQPAG PESPGRFLAR FLANTSFQGR TGPVWVTGSS 

       370        380        390        400        410        420 
QVHMSRHFKV WSLRRDPRGA PAWATVGSWR DGQLDLEPGG ASARPPPPQG AQVWPKLRVV 

       430        440        450        460        470        480 
TLLEHPFVFA RDPDEDGQCP AGQLCLDPGT NDSATLDALF AALANGSAPR ALRKCCYGYC 

       490        500        510        520        530        540 
IDLLERLAED TPFDFELYLV GDGKYGALRD GRWTGLVGDL LAGRAHMAVT SFSINSARSQ 

       550        560        570        580        590        600 
VVDFTSPFFS TSLGIMVRAR DTASPIGAFM WPLHWSTWLG VFAALHLTAL FLTVYEWRSP 

       610        620        630        640        650        660 
YGLTPRGRNR STVFSYSSAL NLCYAILFRR TVSSKTPKCP TGRLLMNLWA IFCLLVLSSY 

       670        680        690        700        710        720 
TANLAAVMVG DKTFEELSGI HDPKLHHPAQ GFRFGTVWES SAEAYIKKSF PDMHAHMRRH 

       730        740        750        760        770        780 
SAPTTPRGVA MLTSDPPKLN AFIMDKSLLD YEVSIDADCK LLTVGKPFAI EGYGIGLPQN 

       790        800        810        820        830        840 
SPLTSNLSEF ISRYKSSGFI DLLHDKWYKM VPCGKRVFAV TETLQMSIYH FAGLFVLLCL 

       850        860        870        880        890        900 
GLGSALLSSL GEHAFFRLAL PRIRKGSRLQ YWLHTSQKIH RALNTEPPEG SKEETAEAEP 

       910        920        930        940        950        960 
SGPEVEQQQQ QQDQPTAPEG WKRARRAVDK ERRVRFLLEP AVVVAPEADA EAEAAPREGP 

       970        980        990       1000       1010       1020 
VWLCSYGRPP AARPTGAPQP GELQELERRI EVARERLRQA LVRRGQLLAQ LGDSARHRPR 

      1030       1040 
RLLQARAAPA EAPPHSGRPG SQE 

« Hide

References

« Hide 'large scale' references
[1]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Nucleotide sequence, genomic organization, and chromosomal localization of genes encoding the human NMDA receptor subunits NR3A and NR3B."
Andersson O., Stenqvist A., Attersand A., von Euler G.
Genomics 78:178-184(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[3]"Motoneuron-specific expression of NR3B, a novel NMDA-type glutamate receptor subunit that works in a dominant-negative manner."
Nishi M., Hinds H., Lu H.-P., Kawata M., Hayashi Y.
J. Neurosci. 21:RC185.1-RC185.6(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[4]"Cloning and expression of the human NMDA receptor subunit NR3B in the adult human hippocampus."
Bendel O., Meijer B., Hurd Y., von Euler G.
Neurosci. Lett. 377:31-36(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC004528 Genomic DNA. Translation: AAC12680.1. Sequence problems.
BK000070 mRNA. Translation: DAA00018.1.
BK004079 mRNA. Translation: DAA04570.1.
CCDSCCDS32861.1.
RefSeqNP_619635.1. NM_138690.1.
UniGeneHs.660378.

3D structure databases

ProteinModelPortalO60391.
SMRO60391. Positions 415-855.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125509. 2 interactions.
MINTMINT-6630966.
STRING9606.ENSP00000234389.

Chemistry

BindingDBO60391.
ChEMBLCHEMBL2094124.
DrugBankDB00145. Glycine.
DB00142. L-Glutamic Acid.
DB01173. Orphenadrine.
GuidetoPHARMACOLOGY461.

PTM databases

PhosphoSiteO60391.

Proteomic databases

PaxDbO60391.
PRIDEO60391.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000234389; ENSP00000234389; ENSG00000116032.
GeneID116444.
KEGGhsa:116444.
UCSCuc002lqo.1. human.

Organism-specific databases

CTD116444.
GeneCardsGC19P001000.
HGNCHGNC:16768. GRIN3B.
MIM606651. gene.
neXtProtNX_O60391.
PharmGKBPA28984.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG320645.
HOGENOMHOG000231528.
HOVERGENHBG052634.
InParanoidO60391.
KOK05214.
OMAHLQLDWA.
OrthoDBEOG7QK0B4.
PhylomeDBO60391.
TreeFamTF314731.

Enzyme and pathway databases

SignaLinkO60391.

Gene expression databases

BgeeO60391.
CleanExHS_GRIN3B.
GenevestigatorO60391.

Family and domain databases

InterProIPR019594. Glu_rcpt_Glu/Gly-bd.
IPR001320. Iontro_glu_rcpt.
IPR001508. NMDA_rcpt.
IPR028082. Peripla_BP_I.
IPR001638. SBP_bac_3.
[Graphical view]
PfamPF00060. Lig_chan. 1 hit.
PF00497. SBP_bac_3. 1 hit.
[Graphical view]
PRINTSPR00177. NMDARECEPTOR.
SMARTSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMSSF53822. SSF53822. 1 hit.
ProtoNetSearch...

Other

GeneWikiGRIN3B.
GenomeRNAi116444.
NextBio79923.
PROO60391.
SOURCESearch...

Entry information

Entry nameNMD3B_HUMAN
AccessionPrimary (citable) accession number: O60391
Secondary accession number(s): Q5EAK7, Q7RTW9
Entry history
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 19, 2005
Last modified: July 9, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM