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Protein

Glutamate receptor ionotropic, NMDA 3B

Gene

GRIN3B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine.

GO - Molecular functioni

GO - Biological processi

  • ionotropic glutamate receptor signaling pathway Source: UniProtKB
  • protein insertion into membrane Source: UniProtKB
  • regulation of calcium ion transport Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Calcium, Magnesium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000116032-MONOMER.
SignaLinkiO60391.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate receptor ionotropic, NMDA 3B
Short name:
GluN3B
Alternative name(s):
N-methyl-D-aspartate receptor subtype 3B
Short name:
NMDAR3B
Short name:
NR3B
Gene namesi
Name:GRIN3B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:16768. GRIN3B.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 564ExtracellularSequence analysisAdd BLAST542
Transmembranei565 – 585HelicalSequence analysisAdd BLAST21
Topological domaini586 – 648CytoplasmicSequence analysisAdd BLAST63
Transmembranei649 – 669HelicalSequence analysisAdd BLAST21
Topological domaini670 – 830ExtracellularSequence analysisAdd BLAST161
Transmembranei831 – 851HelicalSequence analysisAdd BLAST21
Topological domaini852 – 1043CytoplasmicSequence analysisAdd BLAST192

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • neuronal cell body Source: UniProtKB
  • NMDA selective glutamate receptor complex Source: UniProtKB
  • postsynaptic membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi116444.
OpenTargetsiENSG00000116032.
PharmGKBiPA28984.

Chemistry databases

ChEMBLiCHEMBL2094124.
DrugBankiDB00659. Acamprosate.
DB00289. Atomoxetine.
DB00996. Gabapentin.
DB00145. Glycine.
DB01159. Halothane.
DB06738. Ketobemidone.
DB04896. Milnacipran.
DB01173. Orphenadrine.
DB00312. Pentobarbital.
DB01174. Phenobarbital.
DB00418. Secobarbital.

Polymorphism and mutation databases

BioMutaiGRIN3B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001157023 – 1043Glutamate receptor ionotropic, NMDA 3BAdd BLAST1021

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi69N-linked (GlcNAc...)Sequence analysis1
Glycosylationi344N-linked (GlcNAc...)Sequence analysis1
Glycosylationi451N-linked (GlcNAc...)Sequence analysis1
Glycosylationi465N-linked (GlcNAc...)Sequence analysis1
Glycosylationi786N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO60391.
PeptideAtlasiO60391.
PRIDEiO60391.

PTM databases

iPTMnetiO60391.
PhosphoSitePlusiO60391.

Expressioni

Gene expression databases

BgeeiENSG00000116032.
CleanExiHS_GRIN3B.
GenevisibleiO60391. HS.

Organism-specific databases

HPAiCAB004269.

Interactioni

Subunit structurei

Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Does not form functional homomeric channels. Found in a complex containing GRIN1 and GRIN2A (By similarity).By similarity

Protein-protein interaction databases

BioGridi125509. 2 interactors.
MINTiMINT-6630966.
STRINGi9606.ENSP00000234389.

Structurei

3D structure databases

ProteinModelPortaliO60391.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1053. Eukaryota.
ENOG410XNUR. LUCA.
GeneTreeiENSGT00760000119186.
HOGENOMiHOG000231528.
HOVERGENiHBG052634.
InParanoidiO60391.
KOiK05214.
OMAiHLQLDWA.
OrthoDBiEOG091G00PT.
PhylomeDBiO60391.
TreeFamiTF314731.

Family and domain databases

InterProiIPR019594. Glu/Gly-bd.
IPR001508. Iono_rcpt_met.
IPR001320. Iontro_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O60391-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFVRALWLG LALALGPGSA GGHPQPCGVL ARLGGSVRLG ALLPRAPLAR
60 70 80 90 100
ARARAALARA ALAPRLPHNL SLELVVAAPP ARDPASLTRG LCQALVPPGV
110 120 130 140 150
AALLAFPEAR PELLQLHFLA AATETPVLSL LRREARAPLG APNPFHLQLH
160 170 180 190 200
WASPLETLLD VLVAVLQAHA WEDVGLALCR TQDPGGLVAL WTSRAGRPPQ
210 220 230 240 250
LVLDLSRRDT GDAGLRARLA PMAAPVGGEA PVPAAVLLGC DIARARRVLE
260 270 280 290 300
AVPPGPHWLL GTPLPPKALP TAGLPPGLLA LGEVARPPLE AAIHDIVQLV
310 320 330 340 350
ARALGSAAQV QPKRALLPAP VNCGDLQPAG PESPGRFLAR FLANTSFQGR
360 370 380 390 400
TGPVWVTGSS QVHMSRHFKV WSLRRDPRGA PAWATVGSWR DGQLDLEPGG
410 420 430 440 450
ASARPPPPQG AQVWPKLRVV TLLEHPFVFA RDPDEDGQCP AGQLCLDPGT
460 470 480 490 500
NDSATLDALF AALANGSAPR ALRKCCYGYC IDLLERLAED TPFDFELYLV
510 520 530 540 550
GDGKYGALRD GRWTGLVGDL LAGRAHMAVT SFSINSARSQ VVDFTSPFFS
560 570 580 590 600
TSLGIMVRAR DTASPIGAFM WPLHWSTWLG VFAALHLTAL FLTVYEWRSP
610 620 630 640 650
YGLTPRGRNR STVFSYSSAL NLCYAILFRR TVSSKTPKCP TGRLLMNLWA
660 670 680 690 700
IFCLLVLSSY TANLAAVMVG DKTFEELSGI HDPKLHHPAQ GFRFGTVWES
710 720 730 740 750
SAEAYIKKSF PDMHAHMRRH SAPTTPRGVA MLTSDPPKLN AFIMDKSLLD
760 770 780 790 800
YEVSIDADCK LLTVGKPFAI EGYGIGLPQN SPLTSNLSEF ISRYKSSGFI
810 820 830 840 850
DLLHDKWYKM VPCGKRVFAV TETLQMSIYH FAGLFVLLCL GLGSALLSSL
860 870 880 890 900
GEHAFFRLAL PRIRKGSRLQ YWLHTSQKIH RALNTEPPEG SKEETAEAEP
910 920 930 940 950
SGPEVEQQQQ QQDQPTAPEG WKRARRAVDK ERRVRFLLEP AVVVAPEADA
960 970 980 990 1000
EAEAAPREGP VWLCSYGRPP AARPTGAPQP GELQELERRI EVARERLRQA
1010 1020 1030 1040
LVRRGQLLAQ LGDSARHRPR RLLQARAAPA EAPPHSGRPG SQE
Length:1,043
Mass (Da):112,992
Last modified:July 19, 2005 - v2
Checksum:iB7DEB2BEECD6AFEC
GO

Sequence cautioni

The sequence AAC12680 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019676157T → M.Corresponds to variant rs2240154dbSNPEnsembl.1
Natural variantiVAR_019677404R → W.Corresponds to variant rs4807399dbSNPEnsembl.1
Natural variantiVAR_019678414W → R.Corresponds to variant rs2240157dbSNPEnsembl.1
Natural variantiVAR_019679577T → M.Corresponds to variant rs2240158dbSNPEnsembl.1
Natural variantiVAR_061188612T → A.Corresponds to variant rs60621387dbSNPEnsembl.1
Natural variantiVAR_019680845A → T.Corresponds to variant rs2285906dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004528 Genomic DNA. Translation: AAC12680.1. Sequence problems.
BK000070 mRNA. Translation: DAA00018.1.
BK004079 mRNA. Translation: DAA04570.1.
CCDSiCCDS32861.1.
RefSeqiNP_619635.1. NM_138690.2.
UniGeneiHs.660378.

Genome annotation databases

EnsembliENST00000234389; ENSP00000234389; ENSG00000116032.
GeneIDi116444.
KEGGihsa:116444.
UCSCiuc002lqo.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004528 Genomic DNA. Translation: AAC12680.1. Sequence problems.
BK000070 mRNA. Translation: DAA00018.1.
BK004079 mRNA. Translation: DAA04570.1.
CCDSiCCDS32861.1.
RefSeqiNP_619635.1. NM_138690.2.
UniGeneiHs.660378.

3D structure databases

ProteinModelPortaliO60391.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125509. 2 interactors.
MINTiMINT-6630966.
STRINGi9606.ENSP00000234389.

Chemistry databases

ChEMBLiCHEMBL2094124.
DrugBankiDB00659. Acamprosate.
DB00289. Atomoxetine.
DB00996. Gabapentin.
DB00145. Glycine.
DB01159. Halothane.
DB06738. Ketobemidone.
DB04896. Milnacipran.
DB01173. Orphenadrine.
DB00312. Pentobarbital.
DB01174. Phenobarbital.
DB00418. Secobarbital.

PTM databases

iPTMnetiO60391.
PhosphoSitePlusiO60391.

Polymorphism and mutation databases

BioMutaiGRIN3B.

Proteomic databases

PaxDbiO60391.
PeptideAtlasiO60391.
PRIDEiO60391.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000234389; ENSP00000234389; ENSG00000116032.
GeneIDi116444.
KEGGihsa:116444.
UCSCiuc002lqo.2. human.

Organism-specific databases

CTDi116444.
DisGeNETi116444.
GeneCardsiGRIN3B.
HGNCiHGNC:16768. GRIN3B.
HPAiCAB004269.
MIMi606651. gene.
neXtProtiNX_O60391.
OpenTargetsiENSG00000116032.
PharmGKBiPA28984.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1053. Eukaryota.
ENOG410XNUR. LUCA.
GeneTreeiENSGT00760000119186.
HOGENOMiHOG000231528.
HOVERGENiHBG052634.
InParanoidiO60391.
KOiK05214.
OMAiHLQLDWA.
OrthoDBiEOG091G00PT.
PhylomeDBiO60391.
TreeFamiTF314731.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000116032-MONOMER.
SignaLinkiO60391.

Miscellaneous databases

GeneWikiiGRIN3B.
GenomeRNAii116444.
PROiO60391.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000116032.
CleanExiHS_GRIN3B.
GenevisibleiO60391. HS.

Family and domain databases

InterProiIPR019594. Glu/Gly-bd.
IPR001508. Iono_rcpt_met.
IPR001320. Iontro_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNMD3B_HUMAN
AccessioniPrimary (citable) accession number: O60391
Secondary accession number(s): Q5EAK7, Q7RTW9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 19, 2005
Last modified: November 2, 2016
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.