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O60391

- NMD3B_HUMAN

UniProt

O60391 - NMD3B_HUMAN

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Protein

Glutamate receptor ionotropic, NMDA 3B

Gene
GRIN3B
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine.

GO - Molecular functioni

  1. calcium channel activity Source: Ensembl
  2. cation channel activity Source: UniProtKB
  3. extracellular-glutamate-gated ion channel activity Source: RefGenome
  4. glycine binding Source: UniProtKB
  5. neurotransmitter binding Source: UniProtKB
  6. neurotransmitter receptor activity Source: UniProtKB
  7. N-methyl-D-aspartate selective glutamate receptor activity Source: RefGenome

GO - Biological processi

  1. ionotropic glutamate receptor signaling pathway Source: UniProtKB
  2. ion transmembrane transport Source: RefGenome
  3. protein insertion into membrane Source: UniProtKB
  4. regulation of calcium ion transport Source: UniProtKB
  5. synaptic transmission, glutamatergic Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Calcium, Magnesium

Enzyme and pathway databases

SignaLinkiO60391.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate receptor ionotropic, NMDA 3B
Short name:
GluN3B
Alternative name(s):
N-methyl-D-aspartate receptor subtype 3B
Short name:
NMDAR3B
Short name:
NR3B
Gene namesi
Name:GRIN3B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:16768. GRIN3B.

Subcellular locationi

Cell membrane; Multi-pass membrane protein By similarity. Cell junctionsynapsepostsynaptic cell membrane By similarity
Note: Requires the presence of GRIN1 to be targeted at the plasma membrane By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 564542Extracellular Reviewed predictionAdd
BLAST
Transmembranei565 – 58521Helical; Reviewed predictionAdd
BLAST
Topological domaini586 – 64863Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei649 – 66921Helical; Reviewed predictionAdd
BLAST
Topological domaini670 – 830161Extracellular Reviewed predictionAdd
BLAST
Transmembranei831 – 85121Helical; Reviewed predictionAdd
BLAST
Topological domaini852 – 1043192Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. dendrite Source: RefGenome
  3. neuronal cell body Source: UniProtKB
  4. N-methyl-D-aspartate selective glutamate receptor complex Source: UniProtKB
  5. postsynaptic membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28984.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed predictionAdd
BLAST
Chaini23 – 10431021Glutamate receptor ionotropic, NMDA 3BPRO_0000011570Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi69 – 691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi344 – 3441N-linked (GlcNAc...) Reviewed prediction
Glycosylationi451 – 4511N-linked (GlcNAc...) Reviewed prediction
Glycosylationi465 – 4651N-linked (GlcNAc...) Reviewed prediction
Glycosylationi786 – 7861N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO60391.
PRIDEiO60391.

PTM databases

PhosphoSiteiO60391.

Expressioni

Gene expression databases

BgeeiO60391.
CleanExiHS_GRIN3B.
GenevestigatoriO60391.

Interactioni

Subunit structurei

Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Does not form functional homomeric channels. Found in a complex containing GRIN1 and GRIN2A By similarity.

Protein-protein interaction databases

BioGridi125509. 2 interactions.
MINTiMINT-6630966.
STRINGi9606.ENSP00000234389.

Structurei

3D structure databases

ProteinModelPortaliO60391.
SMRiO60391. Positions 415-855.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG320645.
HOGENOMiHOG000231528.
HOVERGENiHBG052634.
InParanoidiO60391.
KOiK05214.
OMAiHLQLDWA.
OrthoDBiEOG7QK0B4.
PhylomeDBiO60391.
TreeFamiTF314731.

Family and domain databases

InterProiIPR019594. Glu_rcpt_Glu/Gly-bd.
IPR001320. Iontro_glu_rcpt.
IPR001508. NMDA_rcpt.
IPR028082. Peripla_BP_I.
IPR001638. SBP_bac_3.
[Graphical view]
PfamiPF00060. Lig_chan. 1 hit.
PF00497. SBP_bac_3. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O60391-1 [UniParc]FASTAAdd to Basket

« Hide

MEFVRALWLG LALALGPGSA GGHPQPCGVL ARLGGSVRLG ALLPRAPLAR     50
ARARAALARA ALAPRLPHNL SLELVVAAPP ARDPASLTRG LCQALVPPGV 100
AALLAFPEAR PELLQLHFLA AATETPVLSL LRREARAPLG APNPFHLQLH 150
WASPLETLLD VLVAVLQAHA WEDVGLALCR TQDPGGLVAL WTSRAGRPPQ 200
LVLDLSRRDT GDAGLRARLA PMAAPVGGEA PVPAAVLLGC DIARARRVLE 250
AVPPGPHWLL GTPLPPKALP TAGLPPGLLA LGEVARPPLE AAIHDIVQLV 300
ARALGSAAQV QPKRALLPAP VNCGDLQPAG PESPGRFLAR FLANTSFQGR 350
TGPVWVTGSS QVHMSRHFKV WSLRRDPRGA PAWATVGSWR DGQLDLEPGG 400
ASARPPPPQG AQVWPKLRVV TLLEHPFVFA RDPDEDGQCP AGQLCLDPGT 450
NDSATLDALF AALANGSAPR ALRKCCYGYC IDLLERLAED TPFDFELYLV 500
GDGKYGALRD GRWTGLVGDL LAGRAHMAVT SFSINSARSQ VVDFTSPFFS 550
TSLGIMVRAR DTASPIGAFM WPLHWSTWLG VFAALHLTAL FLTVYEWRSP 600
YGLTPRGRNR STVFSYSSAL NLCYAILFRR TVSSKTPKCP TGRLLMNLWA 650
IFCLLVLSSY TANLAAVMVG DKTFEELSGI HDPKLHHPAQ GFRFGTVWES 700
SAEAYIKKSF PDMHAHMRRH SAPTTPRGVA MLTSDPPKLN AFIMDKSLLD 750
YEVSIDADCK LLTVGKPFAI EGYGIGLPQN SPLTSNLSEF ISRYKSSGFI 800
DLLHDKWYKM VPCGKRVFAV TETLQMSIYH FAGLFVLLCL GLGSALLSSL 850
GEHAFFRLAL PRIRKGSRLQ YWLHTSQKIH RALNTEPPEG SKEETAEAEP 900
SGPEVEQQQQ QQDQPTAPEG WKRARRAVDK ERRVRFLLEP AVVVAPEADA 950
EAEAAPREGP VWLCSYGRPP AARPTGAPQP GELQELERRI EVARERLRQA 1000
LVRRGQLLAQ LGDSARHRPR RLLQARAAPA EAPPHSGRPG SQE 1043
Length:1,043
Mass (Da):112,992
Last modified:July 19, 2005 - v2
Checksum:iB7DEB2BEECD6AFEC
GO

Sequence cautioni

The sequence AAC12680.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti157 – 1571T → M.
Corresponds to variant rs2240154 [ dbSNP | Ensembl ].
VAR_019676
Natural varianti404 – 4041R → W.
Corresponds to variant rs4807399 [ dbSNP | Ensembl ].
VAR_019677
Natural varianti414 – 4141W → R.
Corresponds to variant rs2240157 [ dbSNP | Ensembl ].
VAR_019678
Natural varianti577 – 5771T → M.
Corresponds to variant rs2240158 [ dbSNP | Ensembl ].
VAR_019679
Natural varianti612 – 6121T → A.
Corresponds to variant rs60621387 [ dbSNP | Ensembl ].
VAR_061188
Natural varianti845 – 8451A → T.
Corresponds to variant rs2285906 [ dbSNP | Ensembl ].
VAR_019680

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC004528 Genomic DNA. Translation: AAC12680.1. Sequence problems.
BK000070 mRNA. Translation: DAA00018.1.
BK004079 mRNA. Translation: DAA04570.1.
CCDSiCCDS32861.1.
RefSeqiNP_619635.1. NM_138690.1.
UniGeneiHs.660378.

Genome annotation databases

EnsembliENST00000234389; ENSP00000234389; ENSG00000116032.
GeneIDi116444.
KEGGihsa:116444.
UCSCiuc002lqo.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC004528 Genomic DNA. Translation: AAC12680.1 . Sequence problems.
BK000070 mRNA. Translation: DAA00018.1 .
BK004079 mRNA. Translation: DAA04570.1 .
CCDSi CCDS32861.1.
RefSeqi NP_619635.1. NM_138690.1.
UniGenei Hs.660378.

3D structure databases

ProteinModelPortali O60391.
SMRi O60391. Positions 415-855.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125509. 2 interactions.
MINTi MINT-6630966.
STRINGi 9606.ENSP00000234389.

Chemistry

BindingDBi O60391.
ChEMBLi CHEMBL2094124.
DrugBanki DB00145. Glycine.
DB00142. L-Glutamic Acid.
DB01173. Orphenadrine.
GuidetoPHARMACOLOGYi 461.

PTM databases

PhosphoSitei O60391.

Proteomic databases

PaxDbi O60391.
PRIDEi O60391.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000234389 ; ENSP00000234389 ; ENSG00000116032 .
GeneIDi 116444.
KEGGi hsa:116444.
UCSCi uc002lqo.1. human.

Organism-specific databases

CTDi 116444.
GeneCardsi GC19P001000.
HGNCi HGNC:16768. GRIN3B.
MIMi 606651. gene.
neXtProti NX_O60391.
PharmGKBi PA28984.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG320645.
HOGENOMi HOG000231528.
HOVERGENi HBG052634.
InParanoidi O60391.
KOi K05214.
OMAi HLQLDWA.
OrthoDBi EOG7QK0B4.
PhylomeDBi O60391.
TreeFami TF314731.

Enzyme and pathway databases

SignaLinki O60391.

Miscellaneous databases

GeneWikii GRIN3B.
GenomeRNAii 116444.
NextBioi 79923.
PROi O60391.
SOURCEi Search...

Gene expression databases

Bgeei O60391.
CleanExi HS_GRIN3B.
Genevestigatori O60391.

Family and domain databases

InterProi IPR019594. Glu_rcpt_Glu/Gly-bd.
IPR001320. Iontro_glu_rcpt.
IPR001508. NMDA_rcpt.
IPR028082. Peripla_BP_I.
IPR001638. SBP_bac_3.
[Graphical view ]
Pfami PF00060. Lig_chan. 1 hit.
PF00497. SBP_bac_3. 1 hit.
[Graphical view ]
PRINTSi PR00177. NMDARECEPTOR.
SMARTi SM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view ]
SUPFAMi SSF53822. SSF53822. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Nucleotide sequence, genomic organization, and chromosomal localization of genes encoding the human NMDA receptor subunits NR3A and NR3B."
    Andersson O., Stenqvist A., Attersand A., von Euler G.
    Genomics 78:178-184(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  3. "Motoneuron-specific expression of NR3B, a novel NMDA-type glutamate receptor subunit that works in a dominant-negative manner."
    Nishi M., Hinds H., Lu H.-P., Kawata M., Hayashi Y.
    J. Neurosci. 21:RC185.1-RC185.6(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  4. "Cloning and expression of the human NMDA receptor subunit NR3B in the adult human hippocampus."
    Bendel O., Meijer B., Hurd Y., von Euler G.
    Neurosci. Lett. 377:31-36(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiNMD3B_HUMAN
AccessioniPrimary (citable) accession number: O60391
Secondary accession number(s): Q5EAK7, Q7RTW9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 19, 2005
Last modified: July 9, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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