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O60391

- NMD3B_HUMAN

UniProt

O60391 - NMD3B_HUMAN

Protein

Glutamate receptor ionotropic, NMDA 3B

Gene

GRIN3B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 2 (19 Jul 2005)
      Previous versions | rss
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    Functioni

    NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine.

    GO - Molecular functioni

    1. calcium channel activity Source: Ensembl
    2. cation channel activity Source: UniProtKB
    3. extracellular-glutamate-gated ion channel activity Source: RefGenome
    4. glycine binding Source: UniProtKB
    5. neurotransmitter binding Source: UniProtKB
    6. neurotransmitter receptor activity Source: UniProtKB
    7. N-methyl-D-aspartate selective glutamate receptor activity Source: RefGenome

    GO - Biological processi

    1. ionotropic glutamate receptor signaling pathway Source: UniProtKB
    2. ion transmembrane transport Source: RefGenome
    3. protein insertion into membrane Source: UniProtKB
    4. regulation of calcium ion transport Source: UniProtKB
    5. synaptic transmission, glutamatergic Source: RefGenome

    Keywords - Molecular functioni

    Ion channel, Ligand-gated ion channel, Receptor

    Keywords - Biological processi

    Ion transport, Transport

    Keywords - Ligandi

    Calcium, Magnesium

    Enzyme and pathway databases

    SignaLinkiO60391.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate receptor ionotropic, NMDA 3B
    Short name:
    GluN3B
    Alternative name(s):
    N-methyl-D-aspartate receptor subtype 3B
    Short name:
    NMDAR3B
    Short name:
    NR3B
    Gene namesi
    Name:GRIN3B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:16768. GRIN3B.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity. Cell junctionsynapsepostsynaptic cell membrane By similarity
    Note: Requires the presence of GRIN1 to be targeted at the plasma membrane.By similarity

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. dendrite Source: RefGenome
    3. neuronal cell body Source: UniProtKB
    4. N-methyl-D-aspartate selective glutamate receptor complex Source: UniProtKB
    5. postsynaptic membrane Source: RefGenome

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28984.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 10431021Glutamate receptor ionotropic, NMDA 3BPRO_0000011570Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi69 – 691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi344 – 3441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi451 – 4511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi465 – 4651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi786 – 7861N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiO60391.
    PRIDEiO60391.

    PTM databases

    PhosphoSiteiO60391.

    Expressioni

    Gene expression databases

    BgeeiO60391.
    CleanExiHS_GRIN3B.
    GenevestigatoriO60391.

    Interactioni

    Subunit structurei

    Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Does not form functional homomeric channels. Found in a complex containing GRIN1 and GRIN2A By similarity.By similarity

    Protein-protein interaction databases

    BioGridi125509. 2 interactions.
    MINTiMINT-6630966.
    STRINGi9606.ENSP00000234389.

    Structurei

    3D structure databases

    ProteinModelPortaliO60391.
    SMRiO60391. Positions 415-855.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini23 – 564542ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini586 – 64863CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini670 – 830161ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini852 – 1043192CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei565 – 58521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei649 – 66921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei831 – 85121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG320645.
    HOGENOMiHOG000231528.
    HOVERGENiHBG052634.
    InParanoidiO60391.
    KOiK05214.
    OMAiHLQLDWA.
    OrthoDBiEOG7QK0B4.
    PhylomeDBiO60391.
    TreeFamiTF314731.

    Family and domain databases

    InterProiIPR019594. Glu_rcpt_Glu/Gly-bd.
    IPR001320. Iontro_glu_rcpt.
    IPR001508. NMDA_rcpt.
    IPR028082. Peripla_BP_I.
    IPR001638. SBP_bac_3.
    [Graphical view]
    PfamiPF00060. Lig_chan. 1 hit.
    PF00497. SBP_bac_3. 1 hit.
    [Graphical view]
    PRINTSiPR00177. NMDARECEPTOR.
    SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
    SM00079. PBPe. 1 hit.
    [Graphical view]
    SUPFAMiSSF53822. SSF53822. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O60391-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEFVRALWLG LALALGPGSA GGHPQPCGVL ARLGGSVRLG ALLPRAPLAR     50
    ARARAALARA ALAPRLPHNL SLELVVAAPP ARDPASLTRG LCQALVPPGV 100
    AALLAFPEAR PELLQLHFLA AATETPVLSL LRREARAPLG APNPFHLQLH 150
    WASPLETLLD VLVAVLQAHA WEDVGLALCR TQDPGGLVAL WTSRAGRPPQ 200
    LVLDLSRRDT GDAGLRARLA PMAAPVGGEA PVPAAVLLGC DIARARRVLE 250
    AVPPGPHWLL GTPLPPKALP TAGLPPGLLA LGEVARPPLE AAIHDIVQLV 300
    ARALGSAAQV QPKRALLPAP VNCGDLQPAG PESPGRFLAR FLANTSFQGR 350
    TGPVWVTGSS QVHMSRHFKV WSLRRDPRGA PAWATVGSWR DGQLDLEPGG 400
    ASARPPPPQG AQVWPKLRVV TLLEHPFVFA RDPDEDGQCP AGQLCLDPGT 450
    NDSATLDALF AALANGSAPR ALRKCCYGYC IDLLERLAED TPFDFELYLV 500
    GDGKYGALRD GRWTGLVGDL LAGRAHMAVT SFSINSARSQ VVDFTSPFFS 550
    TSLGIMVRAR DTASPIGAFM WPLHWSTWLG VFAALHLTAL FLTVYEWRSP 600
    YGLTPRGRNR STVFSYSSAL NLCYAILFRR TVSSKTPKCP TGRLLMNLWA 650
    IFCLLVLSSY TANLAAVMVG DKTFEELSGI HDPKLHHPAQ GFRFGTVWES 700
    SAEAYIKKSF PDMHAHMRRH SAPTTPRGVA MLTSDPPKLN AFIMDKSLLD 750
    YEVSIDADCK LLTVGKPFAI EGYGIGLPQN SPLTSNLSEF ISRYKSSGFI 800
    DLLHDKWYKM VPCGKRVFAV TETLQMSIYH FAGLFVLLCL GLGSALLSSL 850
    GEHAFFRLAL PRIRKGSRLQ YWLHTSQKIH RALNTEPPEG SKEETAEAEP 900
    SGPEVEQQQQ QQDQPTAPEG WKRARRAVDK ERRVRFLLEP AVVVAPEADA 950
    EAEAAPREGP VWLCSYGRPP AARPTGAPQP GELQELERRI EVARERLRQA 1000
    LVRRGQLLAQ LGDSARHRPR RLLQARAAPA EAPPHSGRPG SQE 1043
    Length:1,043
    Mass (Da):112,992
    Last modified:July 19, 2005 - v2
    Checksum:iB7DEB2BEECD6AFEC
    GO

    Sequence cautioni

    The sequence AAC12680.1 differs from that shown. Reason: Erroneous gene model prediction.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti157 – 1571T → M.
    Corresponds to variant rs2240154 [ dbSNP | Ensembl ].
    VAR_019676
    Natural varianti404 – 4041R → W.
    Corresponds to variant rs4807399 [ dbSNP | Ensembl ].
    VAR_019677
    Natural varianti414 – 4141W → R.
    Corresponds to variant rs2240157 [ dbSNP | Ensembl ].
    VAR_019678
    Natural varianti577 – 5771T → M.
    Corresponds to variant rs2240158 [ dbSNP | Ensembl ].
    VAR_019679
    Natural varianti612 – 6121T → A.
    Corresponds to variant rs60621387 [ dbSNP | Ensembl ].
    VAR_061188
    Natural varianti845 – 8451A → T.
    Corresponds to variant rs2285906 [ dbSNP | Ensembl ].
    VAR_019680

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC004528 Genomic DNA. Translation: AAC12680.1. Sequence problems.
    BK000070 mRNA. Translation: DAA00018.1.
    BK004079 mRNA. Translation: DAA04570.1.
    CCDSiCCDS32861.1.
    RefSeqiNP_619635.1. NM_138690.1.
    UniGeneiHs.660378.

    Genome annotation databases

    EnsembliENST00000234389; ENSP00000234389; ENSG00000116032.
    GeneIDi116444.
    KEGGihsa:116444.
    UCSCiuc002lqo.1. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC004528 Genomic DNA. Translation: AAC12680.1 . Sequence problems.
    BK000070 mRNA. Translation: DAA00018.1 .
    BK004079 mRNA. Translation: DAA04570.1 .
    CCDSi CCDS32861.1.
    RefSeqi NP_619635.1. NM_138690.1.
    UniGenei Hs.660378.

    3D structure databases

    ProteinModelPortali O60391.
    SMRi O60391. Positions 415-855.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125509. 2 interactions.
    MINTi MINT-6630966.
    STRINGi 9606.ENSP00000234389.

    Chemistry

    BindingDBi O60391.
    ChEMBLi CHEMBL2094124.
    DrugBanki DB00145. Glycine.
    DB00142. L-Glutamic Acid.
    DB01173. Orphenadrine.
    GuidetoPHARMACOLOGYi 461.

    PTM databases

    PhosphoSitei O60391.

    Proteomic databases

    PaxDbi O60391.
    PRIDEi O60391.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000234389 ; ENSP00000234389 ; ENSG00000116032 .
    GeneIDi 116444.
    KEGGi hsa:116444.
    UCSCi uc002lqo.1. human.

    Organism-specific databases

    CTDi 116444.
    GeneCardsi GC19P001000.
    HGNCi HGNC:16768. GRIN3B.
    MIMi 606651. gene.
    neXtProti NX_O60391.
    PharmGKBi PA28984.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG320645.
    HOGENOMi HOG000231528.
    HOVERGENi HBG052634.
    InParanoidi O60391.
    KOi K05214.
    OMAi HLQLDWA.
    OrthoDBi EOG7QK0B4.
    PhylomeDBi O60391.
    TreeFami TF314731.

    Enzyme and pathway databases

    SignaLinki O60391.

    Miscellaneous databases

    GeneWikii GRIN3B.
    GenomeRNAii 116444.
    NextBioi 79923.
    PROi O60391.
    SOURCEi Search...

    Gene expression databases

    Bgeei O60391.
    CleanExi HS_GRIN3B.
    Genevestigatori O60391.

    Family and domain databases

    InterProi IPR019594. Glu_rcpt_Glu/Gly-bd.
    IPR001320. Iontro_glu_rcpt.
    IPR001508. NMDA_rcpt.
    IPR028082. Peripla_BP_I.
    IPR001638. SBP_bac_3.
    [Graphical view ]
    Pfami PF00060. Lig_chan. 1 hit.
    PF00497. SBP_bac_3. 1 hit.
    [Graphical view ]
    PRINTSi PR00177. NMDARECEPTOR.
    SMARTi SM00918. Lig_chan-Glu_bd. 1 hit.
    SM00079. PBPe. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53822. SSF53822. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Nucleotide sequence, genomic organization, and chromosomal localization of genes encoding the human NMDA receptor subunits NR3A and NR3B."
      Andersson O., Stenqvist A., Attersand A., von Euler G.
      Genomics 78:178-184(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    3. "Motoneuron-specific expression of NR3B, a novel NMDA-type glutamate receptor subunit that works in a dominant-negative manner."
      Nishi M., Hinds H., Lu H.-P., Kawata M., Hayashi Y.
      J. Neurosci. 21:RC185.1-RC185.6(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    4. "Cloning and expression of the human NMDA receptor subunit NR3B in the adult human hippocampus."
      Bendel O., Meijer B., Hurd Y., von Euler G.
      Neurosci. Lett. 377:31-36(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiNMD3B_HUMAN
    AccessioniPrimary (citable) accession number: O60391
    Secondary accession number(s): Q5EAK7, Q7RTW9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 31, 2004
    Last sequence update: July 19, 2005
    Last modified: October 1, 2014
    This is version 117 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3