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O60381

- HBP1_HUMAN

UniProt

O60381 - HBP1_HUMAN

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Protein
HMG box-containing protein 1
Gene
HBP1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the H1F0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.3 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi434 – 50269HMG box
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. RNA binding Source: InterPro
  3. protein binding Source: IntAct
Complete GO annotation...

GO - Biological processi

  1. Wnt signaling pathway Source: UniProtKB-KW
  2. cell cycle arrest Source: UniProtKB
  3. positive regulation of potassium ion transport Source: Ensembl
  4. regulation of transcription, DNA-templated Source: UniProtKB-KW
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation, Wnt signaling pathway

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HMG box-containing protein 1
Alternative name(s):
HMG box transcription factor 1
High mobility group box transcription factor 1
Gene namesi
Name:HBP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:23200. HBP1.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134901346.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 514514HMG box-containing protein 1
PRO_0000048546Add
BLAST

Proteomic databases

MaxQBiO60381.
PaxDbiO60381.
PRIDEiO60381.

PTM databases

PhosphoSiteiO60381.

Expressioni

Gene expression databases

ArrayExpressiO60381.
BgeeiO60381.
CleanExiHS_HBP1.
GenevestigatoriO60381.

Organism-specific databases

HPAiCAB032824.
HPA020225.

Interactioni

Subunit structurei

Binds the second PAH repeat of SIN3A By similarity. Binds TCF4 and RB1.

Binary interactionsi

WithEntry#Exp.IntActNotes
RB1P064002EBI-954175,EBI-491274

Protein-protein interaction databases

BioGridi117927. 17 interactions.
IntActiO60381. 7 interactions.
MINTiMINT-1185770.
STRINGi9606.ENSP00000222574.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi220 – 2278
Helixi234 – 2407
Turni253 – 2608
Beta strandi262 – 27211
Beta strandi275 – 2839
Helixi287 – 2893
Beta strandi292 – 2976
Beta strandi301 – 3044
Turni305 – 3073
Beta strandi308 – 3136
Helixi314 – 3218
Helixi440 – 4478
Helixi449 – 4557
Helixi461 – 47414
Helixi477 – 49721

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2E6ONMR-A424-503[»]
3QVEX-ray2.04A/B/C206-342[»]
ProteinModelPortaliO60381.
SMRiO60381. Positions 208-345, 425-503.

Miscellaneous databases

EvolutionaryTraceiO60381.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini203 – 345143AXH
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi156 – 1616Poly-Ser
Compositional biasi197 – 2004Poly-Asp

Sequence similaritiesi

Contains 1 AXH domain.

Phylogenomic databases

eggNOGiNOG149693.
HOVERGENiHBG052810.
InParanoidiO60381.
OMAiCCEIHIG.
OrthoDBiEOG7VX8VK.
PhylomeDBiO60381.
TreeFamiTF105381.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR013723. Ataxin-1_HBP1.
IPR003652. Ataxin_AXH_dom.
IPR009071. HMG_box_dom.
[Graphical view]
PfamiPF08517. AXH. 1 hit.
PF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00536. AXH. 1 hit.
SM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF102031. SSF102031. 1 hit.
SSF47095. SSF47095. 1 hit.
PROSITEiPS51148. AXH. 1 hit.
PS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O60381-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVWEVKTNQM PNAVQKLLLV MDKRASGMND SLELLQCNEN LPSSPGYNSC    50
DEHMELDDLP ELQAVQSDPT QSGMYQLSSD VSHQEYPRSS WNQNTSDIPE 100
TTYRENEVDW LTELANIATS PQSPLMQCSF YNRSSPVHII ATSKSLHSYA 150
RPPPVSSSSK SEPAFPHHHW KEETPVRHER ANSESESGIF CMSSLSDDDD 200
LGWCNSWPST VWHCFLKGTR LCFHKGSNKE WQDVEDFARA EGCDNEEDLQ 250
MGIHKGYGSD GLKLLSHEES VSFGESVLKL TFDPGTVEDG LLTVECKLDH 300
PFYVKNKGWS SFYPSLTVVQ HGIPCCEVHI GDVCLPPGHP DAINFDDSGV 350
FDTFKSYDFT PMDSSAVYVL SSMARQRRAS LSCGGPGGQD FARSGFSKNC 400
GSPGSSQLSS NSLYAKAVKN HSSGTVSATS PNKCKRPMNA FMLFAKKYRV 450
EYTQMYPGKD NRAISVILGD RWKKMKNEER RMYTLEAKAL AEEQKRLNPD 500
CWKRKRTNSG SQQH 514
Length:514
Mass (Da):57,645
Last modified:July 19, 2005 - v2
Checksum:i2AFADC995F73A031
GO
Isoform 2 (identifier: O60381-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     463-514: Missing.

Note: No experimental confirmation available.

Show »
Length:462
Mass (Da):51,433
Checksum:iF2972041A89482BC
GO
Isoform 3 (identifier: O60381-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     510-514: GSQQH → VCFNK

Show »
Length:514
Mass (Da):57,699
Checksum:i2838539245C3A031
GO

Sequence cautioni

The sequence BAB85059.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei463 – 51452Missing in isoform 2.
VSP_014655Add
BLAST
Alternative sequencei510 – 5145GSQQH → VCFNK in isoform 3.
VSP_014656

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti127 – 1271Q → L in AAH22329. 1 Publication
Sequence conflicti348 – 3481S → P in AAH22329. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF182038 mRNA. Translation: AAD56225.1.
AK074353 mRNA. Translation: BAB85059.1. Different initiation.
AK122785 mRNA. Translation: BAG53729.1.
AC004492 Genomic DNA. Translation: AAC08317.1.
CH471070 Genomic DNA. Translation: EAW83392.1.
BC017069 mRNA. Translation: AAH17069.1.
BC022329 mRNA. Translation: AAH22329.1.
CCDSiCCDS5741.1. [O60381-1]
RefSeqiNP_001231191.1. NM_001244262.1.
NP_036389.2. NM_012257.3. [O60381-1]
XP_005250323.1. XM_005250266.2. [O60381-1]
XP_005250324.1. XM_005250267.2. [O60381-1]
UniGeneiHs.162032.

Genome annotation databases

EnsembliENST00000222574; ENSP00000222574; ENSG00000105856. [O60381-1]
ENST00000468410; ENSP00000420500; ENSG00000105856. [O60381-1]
ENST00000485846; ENSP00000418738; ENSG00000105856. [O60381-1]
GeneIDi26959.
KEGGihsa:26959.
UCSCiuc003vdy.3. human. [O60381-1]
uc003veb.1. human. [O60381-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF182038 mRNA. Translation: AAD56225.1 .
AK074353 mRNA. Translation: BAB85059.1 . Different initiation.
AK122785 mRNA. Translation: BAG53729.1 .
AC004492 Genomic DNA. Translation: AAC08317.1 .
CH471070 Genomic DNA. Translation: EAW83392.1 .
BC017069 mRNA. Translation: AAH17069.1 .
BC022329 mRNA. Translation: AAH22329.1 .
CCDSi CCDS5741.1. [O60381-1 ]
RefSeqi NP_001231191.1. NM_001244262.1.
NP_036389.2. NM_012257.3. [O60381-1 ]
XP_005250323.1. XM_005250266.2. [O60381-1 ]
XP_005250324.1. XM_005250267.2. [O60381-1 ]
UniGenei Hs.162032.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2E6O NMR - A 424-503 [» ]
3QVE X-ray 2.04 A/B/C 206-342 [» ]
ProteinModelPortali O60381.
SMRi O60381. Positions 208-345, 425-503.
ModBasei Search...

Protein-protein interaction databases

BioGridi 117927. 17 interactions.
IntActi O60381. 7 interactions.
MINTi MINT-1185770.
STRINGi 9606.ENSP00000222574.

PTM databases

PhosphoSitei O60381.

Proteomic databases

MaxQBi O60381.
PaxDbi O60381.
PRIDEi O60381.

Protocols and materials databases

DNASUi 26959.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000222574 ; ENSP00000222574 ; ENSG00000105856 . [O60381-1 ]
ENST00000468410 ; ENSP00000420500 ; ENSG00000105856 . [O60381-1 ]
ENST00000485846 ; ENSP00000418738 ; ENSG00000105856 . [O60381-1 ]
GeneIDi 26959.
KEGGi hsa:26959.
UCSCi uc003vdy.3. human. [O60381-1 ]
uc003veb.1. human. [O60381-3 ]

Organism-specific databases

CTDi 26959.
GeneCardsi GC07P106809.
HGNCi HGNC:23200. HBP1.
HPAi CAB032824.
HPA020225.
neXtProti NX_O60381.
PharmGKBi PA134901346.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG149693.
HOVERGENi HBG052810.
InParanoidi O60381.
OMAi CCEIHIG.
OrthoDBi EOG7VX8VK.
PhylomeDBi O60381.
TreeFami TF105381.

Miscellaneous databases

ChiTaRSi HBP1. human.
EvolutionaryTracei O60381.
GeneWikii HBP1.
GenomeRNAii 26959.
NextBioi 49416.
PROi O60381.

Gene expression databases

ArrayExpressi O60381.
Bgeei O60381.
CleanExi HS_HBP1.
Genevestigatori O60381.

Family and domain databases

Gene3Di 1.10.30.10. 1 hit.
InterProi IPR013723. Ataxin-1_HBP1.
IPR003652. Ataxin_AXH_dom.
IPR009071. HMG_box_dom.
[Graphical view ]
Pfami PF08517. AXH. 1 hit.
PF00505. HMG_box. 1 hit.
[Graphical view ]
SMARTi SM00536. AXH. 1 hit.
SM00398. HMG. 1 hit.
[Graphical view ]
SUPFAMi SSF102031. SSF102031. 1 hit.
SSF47095. SSF47095. 1 hit.
PROSITEi PS51148. AXH. 1 hit.
PS50118. HMG_BOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Involvement of retinoblastoma protein and HBP1 in histone H1(0) gene expression."
    Lemercier C., Duncliffe K., Boibessot I., Zhang H., Verdel A., Angelov D., Khochbin S.
    Mol. Cell. Biol. 20:6627-6637(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), FUNCTION, INTERACTION WITH RB1.
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-514 (ISOFORM 2).
    Tissue: Hepatoma and Testis.
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Uterus.
  6. Cited for: FUNCTION, SUBCELLULAR LOCATION.
  7. "Negative regulation of the Wnt-beta-catenin pathway by the transcriptional repressor HBP1."
    Sampson E.M., Haque Z.K., Ku M.-C., Tevosian S.G., Albanese C., Pestell R.G., Paulson K.E., Yee A.S.
    EMBO J. 20:4500-4511(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH TCF4.
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Solution structure of the HMG box domain from human HMG-box transcription factor 1."
    RIKEN structural genomics initiative (RSGI)
    Submitted (JUL-2007) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 422-503.

Entry informationi

Entry nameiHBP1_HUMAN
AccessioniPrimary (citable) accession number: O60381
Secondary accession number(s): B3KVB7
, Q8TBM1, Q8TE93, Q96AJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: July 9, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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