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O60381

- HBP1_HUMAN

UniProt

O60381 - HBP1_HUMAN

Protein

HMG box-containing protein 1

Gene

HBP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 2 (19 Jul 2005)
      Previous versions | rss
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    Functioni

    Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the H1F0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.3 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi434 – 50269HMG boxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. RNA binding Source: InterPro

    GO - Biological processi

    1. cell cycle arrest Source: UniProtKB
    2. positive regulation of potassium ion transport Source: Ensembl
    3. regulation of transcription, DNA-templated Source: UniProtKB-KW
    4. transcription, DNA-templated Source: UniProtKB-KW
    5. Wnt signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation, Wnt signaling pathway

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    HMG box-containing protein 1
    Alternative name(s):
    HMG box transcription factor 1
    High mobility group box transcription factor 1
    Gene namesi
    Name:HBP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:23200. HBP1.

    Subcellular locationi

    Nucleus 1 PublicationPROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134901346.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 514514HMG box-containing protein 1PRO_0000048546Add
    BLAST

    Proteomic databases

    MaxQBiO60381.
    PaxDbiO60381.
    PRIDEiO60381.

    PTM databases

    PhosphoSiteiO60381.

    Expressioni

    Gene expression databases

    ArrayExpressiO60381.
    BgeeiO60381.
    CleanExiHS_HBP1.
    GenevestigatoriO60381.

    Organism-specific databases

    HPAiCAB032824.
    HPA020225.

    Interactioni

    Subunit structurei

    Binds the second PAH repeat of SIN3A By similarity. Binds TCF4 and RB1.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    RB1P064002EBI-954175,EBI-491274

    Protein-protein interaction databases

    BioGridi117927. 17 interactions.
    IntActiO60381. 7 interactions.
    MINTiMINT-1185770.
    STRINGi9606.ENSP00000222574.

    Structurei

    Secondary structure

    1
    514
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi220 – 2278
    Helixi234 – 2407
    Turni253 – 2608
    Beta strandi262 – 27211
    Beta strandi275 – 2839
    Helixi287 – 2893
    Beta strandi292 – 2976
    Beta strandi301 – 3044
    Turni305 – 3073
    Beta strandi308 – 3136
    Helixi314 – 3218
    Helixi440 – 4478
    Helixi449 – 4557
    Helixi461 – 47414
    Helixi477 – 49721

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2E6ONMR-A424-503[»]
    3QVEX-ray2.04A/B/C206-342[»]
    ProteinModelPortaliO60381.
    SMRiO60381. Positions 208-345, 425-503.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO60381.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini203 – 345143AXHPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi156 – 1616Poly-Ser
    Compositional biasi197 – 2004Poly-Asp

    Sequence similaritiesi

    Contains 1 AXH domain.PROSITE-ProRule annotation
    Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG149693.
    HOVERGENiHBG052810.
    InParanoidiO60381.
    OMAiCCEIHIG.
    OrthoDBiEOG7VX8VK.
    PhylomeDBiO60381.
    TreeFamiTF105381.

    Family and domain databases

    Gene3Di1.10.30.10. 1 hit.
    InterProiIPR013723. Ataxin-1_HBP1.
    IPR003652. Ataxin_AXH_dom.
    IPR009071. HMG_box_dom.
    [Graphical view]
    PfamiPF08517. AXH. 1 hit.
    PF00505. HMG_box. 1 hit.
    [Graphical view]
    SMARTiSM00536. AXH. 1 hit.
    SM00398. HMG. 1 hit.
    [Graphical view]
    SUPFAMiSSF102031. SSF102031. 1 hit.
    SSF47095. SSF47095. 1 hit.
    PROSITEiPS51148. AXH. 1 hit.
    PS50118. HMG_BOX_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O60381-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVWEVKTNQM PNAVQKLLLV MDKRASGMND SLELLQCNEN LPSSPGYNSC    50
    DEHMELDDLP ELQAVQSDPT QSGMYQLSSD VSHQEYPRSS WNQNTSDIPE 100
    TTYRENEVDW LTELANIATS PQSPLMQCSF YNRSSPVHII ATSKSLHSYA 150
    RPPPVSSSSK SEPAFPHHHW KEETPVRHER ANSESESGIF CMSSLSDDDD 200
    LGWCNSWPST VWHCFLKGTR LCFHKGSNKE WQDVEDFARA EGCDNEEDLQ 250
    MGIHKGYGSD GLKLLSHEES VSFGESVLKL TFDPGTVEDG LLTVECKLDH 300
    PFYVKNKGWS SFYPSLTVVQ HGIPCCEVHI GDVCLPPGHP DAINFDDSGV 350
    FDTFKSYDFT PMDSSAVYVL SSMARQRRAS LSCGGPGGQD FARSGFSKNC 400
    GSPGSSQLSS NSLYAKAVKN HSSGTVSATS PNKCKRPMNA FMLFAKKYRV 450
    EYTQMYPGKD NRAISVILGD RWKKMKNEER RMYTLEAKAL AEEQKRLNPD 500
    CWKRKRTNSG SQQH 514
    Length:514
    Mass (Da):57,645
    Last modified:July 19, 2005 - v2
    Checksum:i2AFADC995F73A031
    GO
    Isoform 2 (identifier: O60381-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         463-514: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:462
    Mass (Da):51,433
    Checksum:iF2972041A89482BC
    GO
    Isoform 3 (identifier: O60381-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         510-514: GSQQH → VCFNK

    Show »
    Length:514
    Mass (Da):57,699
    Checksum:i2838539245C3A031
    GO

    Sequence cautioni

    The sequence BAB85059.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti127 – 1271Q → L in AAH22329. (PubMed:15489334)Curated
    Sequence conflicti348 – 3481S → P in AAH22329. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei463 – 51452Missing in isoform 2. 1 PublicationVSP_014655Add
    BLAST
    Alternative sequencei510 – 5145GSQQH → VCFNK in isoform 3. 1 PublicationVSP_014656

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF182038 mRNA. Translation: AAD56225.1.
    AK074353 mRNA. Translation: BAB85059.1. Different initiation.
    AK122785 mRNA. Translation: BAG53729.1.
    AC004492 Genomic DNA. Translation: AAC08317.1.
    CH471070 Genomic DNA. Translation: EAW83392.1.
    BC017069 mRNA. Translation: AAH17069.1.
    BC022329 mRNA. Translation: AAH22329.1.
    CCDSiCCDS5741.1. [O60381-1]
    RefSeqiNP_001231191.1. NM_001244262.1.
    NP_036389.2. NM_012257.3. [O60381-1]
    XP_005250323.1. XM_005250266.2. [O60381-1]
    XP_005250324.1. XM_005250267.2. [O60381-1]
    UniGeneiHs.162032.

    Genome annotation databases

    EnsembliENST00000222574; ENSP00000222574; ENSG00000105856. [O60381-1]
    ENST00000468410; ENSP00000420500; ENSG00000105856. [O60381-1]
    ENST00000485846; ENSP00000418738; ENSG00000105856. [O60381-1]
    GeneIDi26959.
    KEGGihsa:26959.
    UCSCiuc003vdy.3. human. [O60381-1]
    uc003veb.1. human. [O60381-3]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF182038 mRNA. Translation: AAD56225.1 .
    AK074353 mRNA. Translation: BAB85059.1 . Different initiation.
    AK122785 mRNA. Translation: BAG53729.1 .
    AC004492 Genomic DNA. Translation: AAC08317.1 .
    CH471070 Genomic DNA. Translation: EAW83392.1 .
    BC017069 mRNA. Translation: AAH17069.1 .
    BC022329 mRNA. Translation: AAH22329.1 .
    CCDSi CCDS5741.1. [O60381-1 ]
    RefSeqi NP_001231191.1. NM_001244262.1.
    NP_036389.2. NM_012257.3. [O60381-1 ]
    XP_005250323.1. XM_005250266.2. [O60381-1 ]
    XP_005250324.1. XM_005250267.2. [O60381-1 ]
    UniGenei Hs.162032.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2E6O NMR - A 424-503 [» ]
    3QVE X-ray 2.04 A/B/C 206-342 [» ]
    ProteinModelPortali O60381.
    SMRi O60381. Positions 208-345, 425-503.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117927. 17 interactions.
    IntActi O60381. 7 interactions.
    MINTi MINT-1185770.
    STRINGi 9606.ENSP00000222574.

    PTM databases

    PhosphoSitei O60381.

    Proteomic databases

    MaxQBi O60381.
    PaxDbi O60381.
    PRIDEi O60381.

    Protocols and materials databases

    DNASUi 26959.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000222574 ; ENSP00000222574 ; ENSG00000105856 . [O60381-1 ]
    ENST00000468410 ; ENSP00000420500 ; ENSG00000105856 . [O60381-1 ]
    ENST00000485846 ; ENSP00000418738 ; ENSG00000105856 . [O60381-1 ]
    GeneIDi 26959.
    KEGGi hsa:26959.
    UCSCi uc003vdy.3. human. [O60381-1 ]
    uc003veb.1. human. [O60381-3 ]

    Organism-specific databases

    CTDi 26959.
    GeneCardsi GC07P106809.
    HGNCi HGNC:23200. HBP1.
    HPAi CAB032824.
    HPA020225.
    neXtProti NX_O60381.
    PharmGKBi PA134901346.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG149693.
    HOVERGENi HBG052810.
    InParanoidi O60381.
    OMAi CCEIHIG.
    OrthoDBi EOG7VX8VK.
    PhylomeDBi O60381.
    TreeFami TF105381.

    Miscellaneous databases

    ChiTaRSi HBP1. human.
    EvolutionaryTracei O60381.
    GeneWikii HBP1.
    GenomeRNAii 26959.
    NextBioi 49416.
    PROi O60381.

    Gene expression databases

    ArrayExpressi O60381.
    Bgeei O60381.
    CleanExi HS_HBP1.
    Genevestigatori O60381.

    Family and domain databases

    Gene3Di 1.10.30.10. 1 hit.
    InterProi IPR013723. Ataxin-1_HBP1.
    IPR003652. Ataxin_AXH_dom.
    IPR009071. HMG_box_dom.
    [Graphical view ]
    Pfami PF08517. AXH. 1 hit.
    PF00505. HMG_box. 1 hit.
    [Graphical view ]
    SMARTi SM00536. AXH. 1 hit.
    SM00398. HMG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF102031. SSF102031. 1 hit.
    SSF47095. SSF47095. 1 hit.
    PROSITEi PS51148. AXH. 1 hit.
    PS50118. HMG_BOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Involvement of retinoblastoma protein and HBP1 in histone H1(0) gene expression."
      Lemercier C., Duncliffe K., Boibessot I., Zhang H., Verdel A., Angelov D., Khochbin S.
      Mol. Cell. Biol. 20:6627-6637(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), FUNCTION, INTERACTION WITH RB1.
      Tissue: Brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-514 (ISOFORM 2).
      Tissue: Hepatoma and Testis.
    3. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain and Uterus.
    6. Cited for: FUNCTION, SUBCELLULAR LOCATION.
    7. "Negative regulation of the Wnt-beta-catenin pathway by the transcriptional repressor HBP1."
      Sampson E.M., Haque Z.K., Ku M.-C., Tevosian S.G., Albanese C., Pestell R.G., Paulson K.E., Yee A.S.
      EMBO J. 20:4500-4511(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH TCF4.
    8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Solution structure of the HMG box domain from human HMG-box transcription factor 1."
      RIKEN structural genomics initiative (RSGI)
      Submitted (JUL-2007) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 422-503.

    Entry informationi

    Entry nameiHBP1_HUMAN
    AccessioniPrimary (citable) accession number: O60381
    Secondary accession number(s): B3KVB7
    , Q8TBM1, Q8TE93, Q96AJ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: July 19, 2005
    Last modified: October 1, 2014
    This is version 113 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3