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Protein

HMG box-containing protein 1

Gene

HBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the H1F0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi434 – 502HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

  • cell cycle arrest Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
  • Wnt signaling pathway Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation, Wnt signaling pathway

Enzyme and pathway databases

SIGNORiO60381

Names & Taxonomyi

Protein namesi
Recommended name:
HMG box-containing protein 1
Alternative name(s):
HMG box transcription factor 1
High mobility group box transcription factor 1
Gene namesi
Name:HBP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000105856.13
HGNCiHGNC:23200 HBP1
neXtProtiNX_O60381

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi26959
OpenTargetsiENSG00000105856
PharmGKBiPA134901346

Polymorphism and mutation databases

BioMutaiHBP1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000485461 – 514HMG box-containing protein 1Add BLAST514

Proteomic databases

EPDiO60381
MaxQBiO60381
PaxDbiO60381
PeptideAtlasiO60381
PRIDEiO60381

PTM databases

iPTMnetiO60381
PhosphoSitePlusiO60381

Expressioni

Gene expression databases

BgeeiENSG00000105856
CleanExiHS_HBP1
ExpressionAtlasiO60381 baseline and differential
GenevisibleiO60381 HS

Organism-specific databases

HPAiCAB032824
HPA020225

Interactioni

Subunit structurei

Binds the second PAH repeat of SIN3A (By similarity). Binds TCF4 and RB1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
RB1P064002EBI-954175,EBI-491274

Protein-protein interaction databases

BioGridi117927, 21 interactors
IntActiO60381, 11 interactors
MINTiO60381
STRINGi9606.ENSP00000222574

Structurei

Secondary structure

1514
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi220 – 227Combined sources8
Helixi234 – 240Combined sources7
Turni253 – 260Combined sources8
Beta strandi262 – 272Combined sources11
Beta strandi275 – 283Combined sources9
Helixi287 – 289Combined sources3
Beta strandi292 – 297Combined sources6
Beta strandi301 – 304Combined sources4
Turni305 – 307Combined sources3
Beta strandi308 – 313Combined sources6
Helixi314 – 321Combined sources8
Helixi440 – 447Combined sources8
Helixi449 – 455Combined sources7
Helixi461 – 474Combined sources14
Helixi477 – 497Combined sources21

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E6ONMR-A424-503[»]
3QVEX-ray2.04A/B/C206-342[»]
ProteinModelPortaliO60381
SMRiO60381
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO60381

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini203 – 345AXHPROSITE-ProRule annotationAdd BLAST143

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi156 – 161Poly-Ser6
Compositional biasi197 – 200Poly-Asp4

Phylogenomic databases

eggNOGiENOG410IFNF Eukaryota
ENOG410XPPV LUCA
GeneTreeiENSGT00390000011239
HOVERGENiHBG052810
InParanoidiO60381
KOiK21644
OMAiIPCCEIH
OrthoDBiEOG091G0SF1
PhylomeDBiO60381
TreeFamiTF105381

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR003652 Ataxin_AXH_dom
IPR036096 Ataxin_AXH_dom_sf
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
PfamiView protein in Pfam
PF08517 AXH, 1 hit
PF00505 HMG_box, 1 hit
SMARTiView protein in SMART
SM00536 AXH, 1 hit
SM00398 HMG, 1 hit
SUPFAMiSSF102031 SSF102031, 1 hit
SSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS51148 AXH, 1 hit
PS50118 HMG_BOX_2, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O60381-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVWEVKTNQM PNAVQKLLLV MDKRASGMND SLELLQCNEN LPSSPGYNSC
60 70 80 90 100
DEHMELDDLP ELQAVQSDPT QSGMYQLSSD VSHQEYPRSS WNQNTSDIPE
110 120 130 140 150
TTYRENEVDW LTELANIATS PQSPLMQCSF YNRSSPVHII ATSKSLHSYA
160 170 180 190 200
RPPPVSSSSK SEPAFPHHHW KEETPVRHER ANSESESGIF CMSSLSDDDD
210 220 230 240 250
LGWCNSWPST VWHCFLKGTR LCFHKGSNKE WQDVEDFARA EGCDNEEDLQ
260 270 280 290 300
MGIHKGYGSD GLKLLSHEES VSFGESVLKL TFDPGTVEDG LLTVECKLDH
310 320 330 340 350
PFYVKNKGWS SFYPSLTVVQ HGIPCCEVHI GDVCLPPGHP DAINFDDSGV
360 370 380 390 400
FDTFKSYDFT PMDSSAVYVL SSMARQRRAS LSCGGPGGQD FARSGFSKNC
410 420 430 440 450
GSPGSSQLSS NSLYAKAVKN HSSGTVSATS PNKCKRPMNA FMLFAKKYRV
460 470 480 490 500
EYTQMYPGKD NRAISVILGD RWKKMKNEER RMYTLEAKAL AEEQKRLNPD
510
CWKRKRTNSG SQQH
Length:514
Mass (Da):57,645
Last modified:July 19, 2005 - v2
Checksum:i2AFADC995F73A031
GO
Isoform 2 (identifier: O60381-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     463-514: Missing.

Note: No experimental confirmation available.
Show »
Length:462
Mass (Da):51,433
Checksum:iF2972041A89482BC
GO
Isoform 3 (identifier: O60381-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     510-514: GSQQH → VCFNK

Show »
Length:514
Mass (Da):57,699
Checksum:i2838539245C3A031
GO

Sequence cautioni

The sequence BAB85059 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti127Q → L in AAH22329 (PubMed:15489334).Curated1
Sequence conflicti348S → P in AAH22329 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014655463 – 514Missing in isoform 2. 1 PublicationAdd BLAST52
Alternative sequenceiVSP_014656510 – 514GSQQH → VCFNK in isoform 3. 1 Publication5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182038 mRNA Translation: AAD56225.1
AK074353 mRNA Translation: BAB85059.1 Different initiation.
AK122785 mRNA Translation: BAG53729.1
AC004492 Genomic DNA Translation: AAC08317.1
CH471070 Genomic DNA Translation: EAW83392.1
BC017069 mRNA Translation: AAH17069.1
BC022329 mRNA Translation: AAH22329.1
CCDSiCCDS5741.1 [O60381-1]
RefSeqiNP_001231191.1, NM_001244262.1
NP_036389.2, NM_012257.3 [O60381-1]
XP_005250323.1, XM_005250266.2 [O60381-1]
XP_005250324.1, XM_005250267.2 [O60381-1]
XP_016867456.1, XM_017011967.1 [O60381-1]
UniGeneiHs.162032

Genome annotation databases

EnsembliENST00000222574; ENSP00000222574; ENSG00000105856 [O60381-1]
ENST00000468410; ENSP00000420500; ENSG00000105856 [O60381-1]
ENST00000485846; ENSP00000418738; ENSG00000105856 [O60381-1]
ENST00000638303; ENSP00000491311; ENSG00000283847 [O60381-1]
ENST00000638893; ENSP00000492167; ENSG00000283847 [O60381-1]
ENST00000640195; ENSP00000492343; ENSG00000283847 [O60381-1]
GeneIDi26959
KEGGihsa:26959
UCSCiuc003vdy.3 human [O60381-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiHBP1_HUMAN
AccessioniPrimary (citable) accession number: O60381
Secondary accession number(s): B3KVB7
, Q8TBM1, Q8TE93, Q96AJ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: May 23, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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