ID   CCG3_HUMAN              Reviewed;         315 AA.
AC   O60359;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   24-JAN-2024, entry version 177.
DE   RecName: Full=Voltage-dependent calcium channel gamma-3 subunit;
DE   AltName: Full=Neuronal voltage-gated calcium channel gamma-3 subunit;
DE   AltName: Full=Transmembrane AMPAR regulatory protein gamma-3;
DE            Short=TARP gamma-3;
GN   Name=CACNG3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Cerebellum;
RX   PubMed=10221464; DOI=10.4065/74.4.357;
RA   Black J.L. III, Lennon V.A.;
RT   "Identification and cloning of putative human neuronal voltage-gated
RT   calcium channel gamma-2 and gamma-3 subunits: neurologic implications.";
RL   Mayo Clin. Proc. 74:357-361(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10493829; DOI=10.1006/geno.1999.5927;
RA   Loftus B.J., Kim U.-J., Sneddon V.P., Kalush F., Brandon R., Fuhrmann J.,
RA   Mason T., Crosby M.L., Barnstead M., Cronin L., Mays A.D., Cao Y., Xu R.X.,
RA   Kang H.-L., Mitchell S., Eichler E.E., Harris P.C., Venter J.C.,
RA   Adams M.D.;
RT   "Genome duplications and other features in 12 Mb of DNA sequence from human
RT   chromosome 16p and 16q.";
RL   Genomics 60:295-308(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain cortex;
RA   Xia J.-H., Zhang H.-L., Tang X.-X., Yu K.-P., Pan Q., Dai H.-P.;
RT   "Cloning of human calcium channel gamma-3 subunit.";
RL   Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Yang J., Yu L., Zhou Y., Dai F.Y., Xin Y.R., Zhao S.Y.;
RT   "Cloning and characterization of a new human cDNA homologous to murine
RT   gamma-2 subunit of voltage-gated Ca2+ channel (Cacng2) mRNA.";
RL   Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Regulates the trafficking to the somatodendritic compartment
CC       and gating properties of AMPA-selective glutamate receptors (AMPARs).
CC       Promotes their targeting to the cell membrane and synapses and
CC       modulates their gating properties by slowing their rates of activation,
CC       deactivation and desensitization. Does not show subunit-specific AMPA
CC       receptor regulation and regulates all AMPAR subunits. Thought to
CC       stabilize the calcium channel in an inactivated (closed) state.
CC       {ECO:0000250|UniProtKB:Q8VHX0}.
CC   -!- SUBUNIT: The L-type calcium channel is composed of five subunits:
CC       alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit
CC       for AMPA-selective glutamate receptors (AMPARs). Found in a complex
CC       with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG4, CACNG5,
CC       CACNG7 and CACNG8. Interacts with AP4M1 and GRIA1; associates GRIA1
CC       with the adaptor protein complex 4 (AP-4) to target GRIA1 to the
CC       somatodendritic compartment of neurons. {ECO:0000250|UniProtKB:Q8VHX0,
CC       ECO:0000250|UniProtKB:Q9JJV5}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}. Note=Displays a somatodendritic localization and
CC       is excluded from axons in neurons. {ECO:0000250|UniProtKB:Q9JJV5}.
CC   -!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AF100346; AAD22739.1; -; mRNA.
DR   EMBL; AC004125; AAC15246.1; -; Genomic_DNA.
DR   EMBL; AF134640; AAF42975.1; -; mRNA.
DR   EMBL; AF114832; AAP97231.1; -; mRNA.
DR   EMBL; BC037899; AAH37899.1; -; mRNA.
DR   EMBL; BC040005; AAH40005.1; -; mRNA.
DR   CCDS; CCDS10620.1; -.
DR   RefSeq; NP_006530.1; NM_006539.3.
DR   AlphaFoldDB; O60359; -.
DR   SMR; O60359; -.
DR   BioGRID; 115647; 11.
DR   IntAct; O60359; 3.
DR   MINT; O60359; -.
DR   STRING; 9606.ENSP00000005284; -.
DR   ChEMBL; CHEMBL2363032; -.
DR   DrugBank; DB13746; Bioallethrin.
DR   DrugBank; DB11148; Butamben.
DR   DrugBank; DB09235; Efonidipine.
DR   DrugBank; DB00228; Enflurane.
DR   DrugBank; DB00153; Ergocalciferol.
DR   DrugBank; DB00622; Nicardipine.
DR   DrugBank; DB00421; Spironolactone.
DR   DrugBank; DB00661; Verapamil.
DR   TCDB; 8.A.16.2.2; the ca(+) channel auxiliary subunit Gama1-Gama8 (ccaGama) family.
DR   GlyGen; O60359; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; O60359; -.
DR   PhosphoSitePlus; O60359; -.
DR   BioMuta; CACNG3; -.
DR   MassIVE; O60359; -.
DR   PaxDb; 9606-ENSP00000005284; -.
DR   PeptideAtlas; O60359; -.
DR   ProteomicsDB; 49380; -.
DR   Antibodypedia; 26064; 270 antibodies from 28 providers.
DR   DNASU; 10368; -.
DR   Ensembl; ENST00000005284.4; ENSP00000005284.4; ENSG00000006116.4.
DR   GeneID; 10368; -.
DR   KEGG; hsa:10368; -.
DR   MANE-Select; ENST00000005284.4; ENSP00000005284.4; NM_006539.4; NP_006530.1.
DR   UCSC; uc002dmf.4; human.
DR   AGR; HGNC:1407; -.
DR   CTD; 10368; -.
DR   DisGeNET; 10368; -.
DR   GeneCards; CACNG3; -.
DR   HGNC; HGNC:1407; CACNG3.
DR   HPA; ENSG00000006116; Group enriched (brain, retina).
DR   MIM; 606403; gene.
DR   neXtProt; NX_O60359; -.
DR   OpenTargets; ENSG00000006116; -.
DR   PharmGKB; PA26017; -.
DR   VEuPathDB; HostDB:ENSG00000006116; -.
DR   eggNOG; ENOG502QVF5; Eukaryota.
DR   GeneTree; ENSGT01050000244893; -.
DR   HOGENOM; CLU_053704_0_1_1; -.
DR   InParanoid; O60359; -.
DR   OMA; GICKQIN; -.
DR   OrthoDB; 2957055at2759; -.
DR   PhylomeDB; O60359; -.
DR   TreeFam; TF327980; -.
DR   PathwayCommons; O60359; -.
DR   Reactome; R-HSA-399719; Trafficking of AMPA receptors.
DR   Reactome; R-HSA-5682910; LGI-ADAM interactions.
DR   SignaLink; O60359; -.
DR   BioGRID-ORCS; 10368; 16 hits in 1140 CRISPR screens.
DR   ChiTaRS; CACNG3; human.
DR   GeneWiki; CACNG3; -.
DR   GenomeRNAi; 10368; -.
DR   Pharos; O60359; Tbio.
DR   PRO; PR:O60359; -.
DR   Proteomes; UP000005640; Chromosome 16.
DR   RNAct; O60359; Protein.
DR   Bgee; ENSG00000006116; Expressed in Brodmann (1909) area 10 and 69 other cell types or tissues.
DR   GO; GO:0032281; C:AMPA glutamate receptor complex; ISS:UniProtKB.
DR   GO; GO:0030425; C:dendrite; IEA:Ensembl.
DR   GO; GO:0030666; C:endocytic vesicle membrane; TAS:Reactome.
DR   GO; GO:0060076; C:excitatory synapse; IEA:Ensembl.
DR   GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0098839; C:postsynaptic density membrane; IBA:GO_Central.
DR   GO; GO:0098685; C:Schaffer collateral - CA1 synapse; IEA:Ensembl.
DR   GO; GO:0036477; C:somatodendritic compartment; ISS:UniProtKB.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; NAS:UniProtKB.
DR   GO; GO:0016247; F:channel regulator activity; IBA:GO_Central.
DR   GO; GO:0035255; F:ionotropic glutamate receptor binding; IEA:Ensembl.
DR   GO; GO:0030165; F:PDZ domain binding; IEA:Ensembl.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IBA:GO_Central.
DR   GO; GO:0006816; P:calcium ion transport; NAS:UniProtKB.
DR   GO; GO:0099590; P:neurotransmitter receptor internalization; IBA:GO_Central.
DR   GO; GO:0099645; P:neurotransmitter receptor localization to postsynaptic specialization membrane; IEA:Ensembl.
DR   GO; GO:0098943; P:neurotransmitter receptor transport, postsynaptic endosome to lysosome; IBA:GO_Central.
DR   GO; GO:0051968; P:positive regulation of synaptic transmission, glutamatergic; IBA:GO_Central.
DR   GO; GO:0098970; P:postsynaptic neurotransmitter receptor diffusion trapping; IBA:GO_Central.
DR   GO; GO:0008104; P:protein localization; ISS:UniProtKB.
DR   GO; GO:0006605; P:protein targeting; ISS:UniProtKB.
DR   GO; GO:2000311; P:regulation of AMPA receptor activity; ISS:UniProtKB.
DR   GO; GO:0019226; P:transmission of nerve impulse; IBA:GO_Central.
DR   Gene3D; 1.20.140.150; -; 1.
DR   InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR   InterPro; IPR008368; VDCC_gsu.
DR   PANTHER; PTHR12107; VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA SUBUNIT; 1.
DR   PANTHER; PTHR12107:SF5; VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-3 SUBUNIT; 1.
DR   Pfam; PF00822; PMP22_Claudin; 1.
DR   PRINTS; PR01792; VDCCGAMMA.
DR   Genevisible; O60359; HS.
PE   2: Evidence at transcript level;
KW   Calcium; Calcium channel; Calcium transport; Ion channel; Ion transport;
KW   Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport; Voltage-gated channel.
FT   CHAIN           1..315
FT                   /note="Voltage-dependent calcium channel gamma-3 subunit"
FT                   /id="PRO_0000164675"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        181..201
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         248
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8VHX0"
SQ   SEQUENCE   315 AA;  35549 MW;  5DCFB9FB44B5A2F4 CRC64;
     MRMCDRGIQM LITTVGAFAA FSLMTIAVGT DYWLYSRGVC RTKSTSDNET SRKNEEVMTH
     SGLWRTCCLE GAFRGVCKKI DHFPEDADYE QDTAEYLLRA VRASSVFPIL SVTLLFFGGL
     CVAASEFHRS RHNVILSAGI FFVSAGLSNI IGIIVYISAN AGDPGQRDSK KSYSYGWSFY
     FGAFSFIIAE IVGVVAVHIY IEKHQQLRAK SHSEFLKKST FARLPPYRYR FRRRSSSRST
     EPRSRDLSPI SKGFHTIPST DISMFTLSRD PSKITMGTLL NSDRDHAFLQ FHNSTPKEFK
     ESLHNNPANR RTTPV
//