Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Voltage-dependent calcium channel gamma-3 subunit

Gene

CACNG3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity).By similarity

GO - Molecular functioni

  1. voltage-gated calcium channel activity Source: UniProtKB

GO - Biological processi

  1. calcium ion transport Source: UniProtKB
  2. regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Source: UniProtKB
  3. synaptic transmission Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_18307. Trafficking of AMPA receptors.

Protein family/group databases

TCDBi8.A.16.2.2. the ca(+) channel auxiliary subunit 1-8 (cca) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent calcium channel gamma-3 subunit
Alternative name(s):
Neuronal voltage-gated calcium channel gamma-3 subunit
Transmembrane AMPAR regulatory protein gamma-3
Short name:
TARP gamma-3
Gene namesi
Name:CACNG3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:1407. CACNG3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei8 – 2821HelicalSequence AnalysisAdd
BLAST
Transmembranei104 – 12421HelicalSequence AnalysisAdd
BLAST
Transmembranei135 – 15521HelicalSequence AnalysisAdd
BLAST
Transmembranei181 – 20121HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex Source: UniProtKB
  2. endocytic vesicle membrane Source: Reactome
  3. plasma membrane Source: Reactome
  4. voltage-gated calcium channel complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26017.

Polymorphism and mutation databases

BioMutaiCACNG3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 315315Voltage-dependent calcium channel gamma-3 subunitPRO_0000164675Add
BLAST

Proteomic databases

PaxDbiO60359.
PRIDEiO60359.

PTM databases

PhosphoSiteiO60359.

Expressioni

Gene expression databases

BgeeiO60359.
CleanExiHS_CACNG3.
GenevestigatoriO60359.

Organism-specific databases

HPAiHPA059010.

Interactioni

Subunit structurei

The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG4, CACNG5, CACNG7 and CACNG8 (By similarity).By similarity

Protein-protein interaction databases

BioGridi115647. 3 interactions.
STRINGi9606.ENSP00000005284.

Structurei

3D structure databases

ProteinModelPortaliO60359.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG48125.
GeneTreeiENSGT00550000074547.
HOGENOMiHOG000233440.
HOVERGENiHBG003682.
InParanoidiO60359.
KOiK04868.
OMAiKHNVILS.
OrthoDBiEOG7TQV1Q.
PhylomeDBiO60359.
TreeFamiTF327980.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
IPR008368. VDCC_gsu.
[Graphical view]
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01792. VDCCGAMMA.

Sequencei

Sequence statusi: Complete.

O60359-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRMCDRGIQM LITTVGAFAA FSLMTIAVGT DYWLYSRGVC RTKSTSDNET
60 70 80 90 100
SRKNEEVMTH SGLWRTCCLE GAFRGVCKKI DHFPEDADYE QDTAEYLLRA
110 120 130 140 150
VRASSVFPIL SVTLLFFGGL CVAASEFHRS RHNVILSAGI FFVSAGLSNI
160 170 180 190 200
IGIIVYISAN AGDPGQRDSK KSYSYGWSFY FGAFSFIIAE IVGVVAVHIY
210 220 230 240 250
IEKHQQLRAK SHSEFLKKST FARLPPYRYR FRRRSSSRST EPRSRDLSPI
260 270 280 290 300
SKGFHTIPST DISMFTLSRD PSKITMGTLL NSDRDHAFLQ FHNSTPKEFK
310
ESLHNNPANR RTTPV
Length:315
Mass (Da):35,549
Last modified:August 1, 1998 - v1
Checksum:i5DCFB9FB44B5A2F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF100346 mRNA. Translation: AAD22739.1.
AC004125 Genomic DNA. Translation: AAC15246.1.
AF134640 mRNA. Translation: AAF42975.1.
AF114832 mRNA. Translation: AAP97231.1.
BC037899 mRNA. Translation: AAH37899.1.
BC040005 mRNA. Translation: AAH40005.1.
CCDSiCCDS10620.1.
RefSeqiNP_006530.1. NM_006539.3.
UniGeneiHs.7235.

Genome annotation databases

EnsembliENST00000005284; ENSP00000005284; ENSG00000006116.
GeneIDi10368.
KEGGihsa:10368.
UCSCiuc002dmf.3. human.

Polymorphism and mutation databases

BioMutaiCACNG3.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF100346 mRNA. Translation: AAD22739.1.
AC004125 Genomic DNA. Translation: AAC15246.1.
AF134640 mRNA. Translation: AAF42975.1.
AF114832 mRNA. Translation: AAP97231.1.
BC037899 mRNA. Translation: AAH37899.1.
BC040005 mRNA. Translation: AAH40005.1.
CCDSiCCDS10620.1.
RefSeqiNP_006530.1. NM_006539.3.
UniGeneiHs.7235.

3D structure databases

ProteinModelPortaliO60359.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115647. 3 interactions.
STRINGi9606.ENSP00000005284.

Chemistry

ChEMBLiCHEMBL2363032.

Protein family/group databases

TCDBi8.A.16.2.2. the ca(+) channel auxiliary subunit 1-8 (cca) family.

PTM databases

PhosphoSiteiO60359.

Polymorphism and mutation databases

BioMutaiCACNG3.

Proteomic databases

PaxDbiO60359.
PRIDEiO60359.

Protocols and materials databases

DNASUi10368.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000005284; ENSP00000005284; ENSG00000006116.
GeneIDi10368.
KEGGihsa:10368.
UCSCiuc002dmf.3. human.

Organism-specific databases

CTDi10368.
GeneCardsiGC16P024267.
HGNCiHGNC:1407. CACNG3.
HPAiHPA059010.
MIMi606403. gene.
neXtProtiNX_O60359.
PharmGKBiPA26017.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG48125.
GeneTreeiENSGT00550000074547.
HOGENOMiHOG000233440.
HOVERGENiHBG003682.
InParanoidiO60359.
KOiK04868.
OMAiKHNVILS.
OrthoDBiEOG7TQV1Q.
PhylomeDBiO60359.
TreeFamiTF327980.

Enzyme and pathway databases

ReactomeiREACT_18307. Trafficking of AMPA receptors.

Miscellaneous databases

GeneWikiiCACNG3.
GenomeRNAii10368.
NextBioi39299.
PROiO60359.
SOURCEiSearch...

Gene expression databases

BgeeiO60359.
CleanExiHS_CACNG3.
GenevestigatoriO60359.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
IPR008368. VDCC_gsu.
[Graphical view]
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01792. VDCCGAMMA.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and cloning of putative human neuronal voltage-gated calcium channel gamma-2 and gamma-3 subunits: neurologic implications."
    Black J.L. III, Lennon V.A.
    Mayo Clin. Proc. 74:357-361(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Cerebellum.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Cloning of human calcium channel gamma-3 subunit."
    Xia J.-H., Zhang H.-L., Tang X.-X., Yu K.-P., Pan Q., Dai H.-P.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain cortex.
  4. "Cloning and characterization of a new human cDNA homologous to murine gamma-2 subunit of voltage-gated Ca2+ channel (Cacng2) mRNA."
    Yang J., Yu L., Zhou Y., Dai F.Y., Xin Y.R., Zhao S.Y.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCCG3_HUMAN
AccessioniPrimary (citable) accession number: O60359
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: April 29, 2015
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.