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O60359

- CCG3_HUMAN

UniProt

O60359 - CCG3_HUMAN

Protein

Voltage-dependent calcium channel gamma-3 subunit

Gene

CACNG3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state By similarity.By similarity

    GO - Molecular functioni

    1. voltage-gated calcium channel activity Source: UniProtKB

    GO - Biological processi

    1. calcium ion transport Source: UniProtKB
    2. regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Source: UniProtKB
    3. synaptic transmission Source: Reactome

    Keywords - Molecular functioni

    Calcium channel, Ion channel, Voltage-gated channel

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    Calcium

    Enzyme and pathway databases

    ReactomeiREACT_18307. Trafficking of AMPA receptors.

    Protein family/group databases

    TCDBi8.A.16.2.2. the ca(+) channel auxiliary subunit 1-8 (cca) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Voltage-dependent calcium channel gamma-3 subunit
    Alternative name(s):
    Neuronal voltage-gated calcium channel gamma-3 subunit
    Transmembrane AMPAR regulatory protein gamma-3
    Short name:
    TARP gamma-3
    Gene namesi
    Name:CACNG3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:1407. CACNG3.

    Subcellular locationi

    GO - Cellular componenti

    1. alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex Source: UniProtKB
    2. endocytic vesicle membrane Source: Reactome
    3. plasma membrane Source: Reactome
    4. voltage-gated calcium channel complex Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26017.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 315315Voltage-dependent calcium channel gamma-3 subunitPRO_0000164675Add
    BLAST

    Proteomic databases

    PaxDbiO60359.
    PRIDEiO60359.

    PTM databases

    PhosphoSiteiO60359.

    Expressioni

    Gene expression databases

    BgeeiO60359.
    CleanExiHS_CACNG3.
    GenevestigatoriO60359.

    Organism-specific databases

    HPAiHPA059010.

    Interactioni

    Subunit structurei

    The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG4, CACNG5, CACNG7 and CACNG8 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi115647. 1 interaction.
    STRINGi9606.ENSP00000005284.

    Structurei

    3D structure databases

    ProteinModelPortaliO60359.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei8 – 2821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei104 – 12421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei135 – 15521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei181 – 20121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG48125.
    HOGENOMiHOG000233440.
    HOVERGENiHBG003682.
    InParanoidiO60359.
    KOiK04868.
    OMAiKHNVILS.
    OrthoDBiEOG7TQV1Q.
    PhylomeDBiO60359.
    TreeFamiTF327980.

    Family and domain databases

    InterProiIPR004031. PMP22/EMP/MP20/Claudin.
    IPR008368. VDCC_gsu.
    [Graphical view]
    PfamiPF00822. PMP22_Claudin. 1 hit.
    [Graphical view]
    PRINTSiPR01792. VDCCGAMMA.

    Sequencei

    Sequence statusi: Complete.

    O60359-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRMCDRGIQM LITTVGAFAA FSLMTIAVGT DYWLYSRGVC RTKSTSDNET    50
    SRKNEEVMTH SGLWRTCCLE GAFRGVCKKI DHFPEDADYE QDTAEYLLRA 100
    VRASSVFPIL SVTLLFFGGL CVAASEFHRS RHNVILSAGI FFVSAGLSNI 150
    IGIIVYISAN AGDPGQRDSK KSYSYGWSFY FGAFSFIIAE IVGVVAVHIY 200
    IEKHQQLRAK SHSEFLKKST FARLPPYRYR FRRRSSSRST EPRSRDLSPI 250
    SKGFHTIPST DISMFTLSRD PSKITMGTLL NSDRDHAFLQ FHNSTPKEFK 300
    ESLHNNPANR RTTPV 315
    Length:315
    Mass (Da):35,549
    Last modified:August 1, 1998 - v1
    Checksum:i5DCFB9FB44B5A2F4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF100346 mRNA. Translation: AAD22739.1.
    AC004125 Genomic DNA. Translation: AAC15246.1.
    AF134640 mRNA. Translation: AAF42975.1.
    AF114832 mRNA. Translation: AAP97231.1.
    BC037899 mRNA. Translation: AAH37899.1.
    BC040005 mRNA. Translation: AAH40005.1.
    CCDSiCCDS10620.1.
    RefSeqiNP_006530.1. NM_006539.3.
    UniGeneiHs.7235.

    Genome annotation databases

    EnsembliENST00000005284; ENSP00000005284; ENSG00000006116.
    GeneIDi10368.
    KEGGihsa:10368.
    UCSCiuc002dmf.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF100346 mRNA. Translation: AAD22739.1 .
    AC004125 Genomic DNA. Translation: AAC15246.1 .
    AF134640 mRNA. Translation: AAF42975.1 .
    AF114832 mRNA. Translation: AAP97231.1 .
    BC037899 mRNA. Translation: AAH37899.1 .
    BC040005 mRNA. Translation: AAH40005.1 .
    CCDSi CCDS10620.1.
    RefSeqi NP_006530.1. NM_006539.3.
    UniGenei Hs.7235.

    3D structure databases

    ProteinModelPortali O60359.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115647. 1 interaction.
    STRINGi 9606.ENSP00000005284.

    Chemistry

    ChEMBLi CHEMBL2363032.

    Protein family/group databases

    TCDBi 8.A.16.2.2. the ca(+) channel auxiliary subunit 1-8 (cca) family.

    PTM databases

    PhosphoSitei O60359.

    Proteomic databases

    PaxDbi O60359.
    PRIDEi O60359.

    Protocols and materials databases

    DNASUi 10368.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000005284 ; ENSP00000005284 ; ENSG00000006116 .
    GeneIDi 10368.
    KEGGi hsa:10368.
    UCSCi uc002dmf.3. human.

    Organism-specific databases

    CTDi 10368.
    GeneCardsi GC16P024267.
    HGNCi HGNC:1407. CACNG3.
    HPAi HPA059010.
    MIMi 606403. gene.
    neXtProti NX_O60359.
    PharmGKBi PA26017.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG48125.
    HOGENOMi HOG000233440.
    HOVERGENi HBG003682.
    InParanoidi O60359.
    KOi K04868.
    OMAi KHNVILS.
    OrthoDBi EOG7TQV1Q.
    PhylomeDBi O60359.
    TreeFami TF327980.

    Enzyme and pathway databases

    Reactomei REACT_18307. Trafficking of AMPA receptors.

    Miscellaneous databases

    GeneWikii CACNG3.
    GenomeRNAii 10368.
    NextBioi 39299.
    PROi O60359.
    SOURCEi Search...

    Gene expression databases

    Bgeei O60359.
    CleanExi HS_CACNG3.
    Genevestigatori O60359.

    Family and domain databases

    InterProi IPR004031. PMP22/EMP/MP20/Claudin.
    IPR008368. VDCC_gsu.
    [Graphical view ]
    Pfami PF00822. PMP22_Claudin. 1 hit.
    [Graphical view ]
    PRINTSi PR01792. VDCCGAMMA.
    ProtoNeti Search...

    Publicationsi

    1. "Identification and cloning of putative human neuronal voltage-gated calcium channel gamma-2 and gamma-3 subunits: neurologic implications."
      Black J.L. III, Lennon V.A.
      Mayo Clin. Proc. 74:357-361(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Cerebellum.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Cloning of human calcium channel gamma-3 subunit."
      Xia J.-H., Zhang H.-L., Tang X.-X., Yu K.-P., Pan Q., Dai H.-P.
      Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain cortex.
    4. "Cloning and characterization of a new human cDNA homologous to murine gamma-2 subunit of voltage-gated Ca2+ channel (Cacng2) mRNA."
      Yang J., Yu L., Zhou Y., Dai F.Y., Xin Y.R., Zhao S.Y.
      Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiCCG3_HUMAN
    AccessioniPrimary (citable) accession number: O60359
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3