SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O60359

- CCG3_HUMAN

UniProt

O60359 - CCG3_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Voltage-dependent calcium channel gamma-3 subunit

Gene
CACNG3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state By similarity.

GO - Molecular functioni

  1. voltage-gated calcium channel activity Source: UniProtKB

GO - Biological processi

  1. calcium ion transport Source: UniProtKB
  2. regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Source: UniProtKB
  3. synaptic transmission Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_18307. Trafficking of AMPA receptors.

Protein family/group databases

TCDBi8.A.16.2.2. the ca(+) channel auxiliary subunit 1-8 (cca) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent calcium channel gamma-3 subunit
Alternative name(s):
Neuronal voltage-gated calcium channel gamma-3 subunit
Transmembrane AMPAR regulatory protein gamma-3
Short name:
TARP gamma-3
Gene namesi
Name:CACNG3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:1407. CACNG3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei8 – 2821Helical; Reviewed predictionAdd
BLAST
Transmembranei104 – 12421Helical; Reviewed predictionAdd
BLAST
Transmembranei135 – 15521Helical; Reviewed predictionAdd
BLAST
Transmembranei181 – 20121Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex Source: UniProtKB
  2. endocytic vesicle membrane Source: Reactome
  3. plasma membrane Source: Reactome
  4. voltage-gated calcium channel complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26017.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 315315Voltage-dependent calcium channel gamma-3 subunitPRO_0000164675Add
BLAST

Proteomic databases

PaxDbiO60359.
PRIDEiO60359.

PTM databases

PhosphoSiteiO60359.

Expressioni

Gene expression databases

BgeeiO60359.
CleanExiHS_CACNG3.
GenevestigatoriO60359.

Organism-specific databases

HPAiHPA059010.

Interactioni

Subunit structurei

The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG4, CACNG5, CACNG7 and CACNG8 By similarity.

Protein-protein interaction databases

BioGridi115647. 1 interaction.
STRINGi9606.ENSP00000005284.

Structurei

3D structure databases

ProteinModelPortaliO60359.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG48125.
HOGENOMiHOG000233440.
HOVERGENiHBG003682.
InParanoidiO60359.
KOiK04868.
OMAiKHNVILS.
OrthoDBiEOG7TQV1Q.
PhylomeDBiO60359.
TreeFamiTF327980.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
IPR008368. VDCC_gsu.
[Graphical view]
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01792. VDCCGAMMA.

Sequencei

Sequence statusi: Complete.

O60359-1 [UniParc]FASTAAdd to Basket

« Hide

MRMCDRGIQM LITTVGAFAA FSLMTIAVGT DYWLYSRGVC RTKSTSDNET    50
SRKNEEVMTH SGLWRTCCLE GAFRGVCKKI DHFPEDADYE QDTAEYLLRA 100
VRASSVFPIL SVTLLFFGGL CVAASEFHRS RHNVILSAGI FFVSAGLSNI 150
IGIIVYISAN AGDPGQRDSK KSYSYGWSFY FGAFSFIIAE IVGVVAVHIY 200
IEKHQQLRAK SHSEFLKKST FARLPPYRYR FRRRSSSRST EPRSRDLSPI 250
SKGFHTIPST DISMFTLSRD PSKITMGTLL NSDRDHAFLQ FHNSTPKEFK 300
ESLHNNPANR RTTPV 315
Length:315
Mass (Da):35,549
Last modified:August 1, 1998 - v1
Checksum:i5DCFB9FB44B5A2F4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF100346 mRNA. Translation: AAD22739.1.
AC004125 Genomic DNA. Translation: AAC15246.1.
AF134640 mRNA. Translation: AAF42975.1.
AF114832 mRNA. Translation: AAP97231.1.
BC037899 mRNA. Translation: AAH37899.1.
BC040005 mRNA. Translation: AAH40005.1.
CCDSiCCDS10620.1.
RefSeqiNP_006530.1. NM_006539.3.
UniGeneiHs.7235.

Genome annotation databases

EnsembliENST00000005284; ENSP00000005284; ENSG00000006116.
GeneIDi10368.
KEGGihsa:10368.
UCSCiuc002dmf.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF100346 mRNA. Translation: AAD22739.1 .
AC004125 Genomic DNA. Translation: AAC15246.1 .
AF134640 mRNA. Translation: AAF42975.1 .
AF114832 mRNA. Translation: AAP97231.1 .
BC037899 mRNA. Translation: AAH37899.1 .
BC040005 mRNA. Translation: AAH40005.1 .
CCDSi CCDS10620.1.
RefSeqi NP_006530.1. NM_006539.3.
UniGenei Hs.7235.

3D structure databases

ProteinModelPortali O60359.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115647. 1 interaction.
STRINGi 9606.ENSP00000005284.

Chemistry

ChEMBLi CHEMBL2363032.

Protein family/group databases

TCDBi 8.A.16.2.2. the ca(+) channel auxiliary subunit 1-8 (cca) family.

PTM databases

PhosphoSitei O60359.

Proteomic databases

PaxDbi O60359.
PRIDEi O60359.

Protocols and materials databases

DNASUi 10368.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000005284 ; ENSP00000005284 ; ENSG00000006116 .
GeneIDi 10368.
KEGGi hsa:10368.
UCSCi uc002dmf.3. human.

Organism-specific databases

CTDi 10368.
GeneCardsi GC16P024267.
HGNCi HGNC:1407. CACNG3.
HPAi HPA059010.
MIMi 606403. gene.
neXtProti NX_O60359.
PharmGKBi PA26017.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG48125.
HOGENOMi HOG000233440.
HOVERGENi HBG003682.
InParanoidi O60359.
KOi K04868.
OMAi KHNVILS.
OrthoDBi EOG7TQV1Q.
PhylomeDBi O60359.
TreeFami TF327980.

Enzyme and pathway databases

Reactomei REACT_18307. Trafficking of AMPA receptors.

Miscellaneous databases

GeneWikii CACNG3.
GenomeRNAii 10368.
NextBioi 39299.
PROi O60359.
SOURCEi Search...

Gene expression databases

Bgeei O60359.
CleanExi HS_CACNG3.
Genevestigatori O60359.

Family and domain databases

InterProi IPR004031. PMP22/EMP/MP20/Claudin.
IPR008368. VDCC_gsu.
[Graphical view ]
Pfami PF00822. PMP22_Claudin. 1 hit.
[Graphical view ]
PRINTSi PR01792. VDCCGAMMA.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and cloning of putative human neuronal voltage-gated calcium channel gamma-2 and gamma-3 subunits: neurologic implications."
    Black J.L. III, Lennon V.A.
    Mayo Clin. Proc. 74:357-361(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Cerebellum.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Cloning of human calcium channel gamma-3 subunit."
    Xia J.-H., Zhang H.-L., Tang X.-X., Yu K.-P., Pan Q., Dai H.-P.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain cortex.
  4. "Cloning and characterization of a new human cDNA homologous to murine gamma-2 subunit of voltage-gated Ca2+ channel (Cacng2) mRNA."
    Yang J., Yu L., Zhou Y., Dai F.Y., Xin Y.R., Zhao S.Y.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCCG3_HUMAN
AccessioniPrimary (citable) accession number: O60359
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: September 3, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi