O60359 (CCG3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Voltage-dependent calcium channel gamma-3 subunit

Alternative name(s):
Neuronal voltage-gated calcium channel gamma-3 subunit
Transmembrane AMPAR regulatory protein gamma-3
Short name=TARP gamma-3

Gene names

Name:

CACNG3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	315 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state By similarity.
Subunit structure	The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG4, CACNG5, CACNG7 and CACNG8 By similarity.
Subcellular location	Membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Calcium
Molecular function	Calcium channel Ion channel Voltage-gated channel
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Inferred from sequence or structural similarity. Source: UniProtKB synaptic transmission Traceable author statement. Source: Reactome
Cellular_component	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex Inferred from sequence or structural similarity. Source: UniProtKB endocytic vesicle membrane Traceable author statement. Source: Reactome voltage-gated calcium channel complex Non-traceable author statement Ref.1. Source: UniProtKB
Molecular_function	voltage-gated calcium channel activity Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 315	315	Voltage-dependent calcium channel gamma-3 subunit		PRO_0000164675
Regions
	Transmembrane	8 – 28	21	Helical; Potential
	Transmembrane	104 – 124	21	Helical; Potential
	Transmembrane	135 – 155	21	Helical; Potential
	Transmembrane	181 – 201	21	Helical; Potential
Amino acid modifications
	Modified residue	248	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	O60359 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 5DCFB9FB44B5A2F4	FASTA	315	35,549
	10 20 30 40 50 60 MRMCDRGIQM LITTVGAFAA FSLMTIAVGT DYWLYSRGVC RTKSTSDNET SRKNEEVMTH 70 80 90 100 110 120 SGLWRTCCLE GAFRGVCKKI DHFPEDADYE QDTAEYLLRA VRASSVFPIL SVTLLFFGGL 130 140 150 160 170 180 CVAASEFHRS RHNVILSAGI FFVSAGLSNI IGIIVYISAN AGDPGQRDSK KSYSYGWSFY 190 200 210 220 230 240 FGAFSFIIAE IVGVVAVHIY IEKHQQLRAK SHSEFLKKST FARLPPYRYR FRRRSSSRST 250 260 270 280 290 300 EPRSRDLSPI SKGFHTIPST DISMFTLSRD PSKITMGTLL NSDRDHAFLQ FHNSTPKEFK 310 ESLHNNPANR RTTPV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and cloning of putative human neuronal voltage-gated calcium channel gamma-2 and gamma-3 subunits: neurologic implications." Black J.L. III, Lennon V.A. Mayo Clin. Proc. 74:357-361(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Cerebellum.
[2]	"Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q." Loftus B.J., Kim U.-J., Sneddon V.P., Kalush F., Brandon R., Fuhrmann J., Mason T., Crosby M.L., Barnstead M., Cronin L., Mays A.D., Cao Y., Xu R.X., Kang H.-L., Mitchell S., Eichler E.E., Harris P.C., Venter J.C., Adams M.D. Genomics 60:295-308(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Cloning of human calcium channel gamma-3 subunit." Xia J.-H., Zhang H.-L., Tang X.-X., Yu K.-P., Pan Q., Dai H.-P. Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain cortex.
[4]	"Cloning and characterization of a new human cDNA homologous to murine gamma-2 subunit of voltage-gated Ca2+ channel (Cacng2) mRNA." Yang J., Yu L., Zhou Y., Dai F.Y., Xin Y.R., Zhao S.Y. Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF100346 mRNA. Translation: AAD22739.1. AC004125 Genomic DNA. Translation: AAC15246.1. AF134640 mRNA. Translation: AAF42975.1. AF114832 mRNA. Translation: AAP97231.1. BC037899 mRNA. Translation: AAH37899.1. BC040005 mRNA. Translation: AAH40005.1.
IPI	IPI00029074.
RefSeq	NP_006530.1. NM_006539.3.
UniGene	Hs.7235.
3D structure databases
ProteinModelPortal	O60359.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000005284.
Protein family/group databases
TCDB	8.A.16.2.2. Ca+ channel auxiliary subunit gamma1-gamma8 (CCAgamma) family.
PTM databases
PhosphoSite	O60359.
Proteomic databases
PaxDb	O60359.
PRIDE	O60359.
Protocols and materials databases
DNASU	10368.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000005284; ENSP00000005284; ENSG00000006116.
GeneID	10368.
KEGG	hsa:10368.
UCSC	uc002dmf.3. human.
Organism-specific databases
CTD	10368.
GeneCards	GC16P024267.
HGNC	HGNC:1407. CACNG3.
MIM	606403. gene.
neXtProt	NX_O60359.
PharmGKB	PA26017.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG48125.
HOGENOM	HOG000233440.
HOVERGEN	HBG003682.
InParanoid	O60359.
KO	K04868.
OMA	DSLHNNP.
OrthoDB	EOG4P5K9M.
PhylomeDB	O60359.
Enzyme and pathway databases
Reactome	REACT_13685. Neuronal System.
Gene expression databases
Bgee	O60359.
CleanEx	HS_CACNG3.
Genevestigator	O60359.
GermOnline	ENSG00000006116. Homo sapiens.
Family and domain databases
InterPro	IPR004031. PMP22/EMP/MP20/Claudin. IPR008368. VDCC_gsu. [Graphical view]
Pfam	PF00822. PMP22_Claudin. 1 hit. [Graphical view]
PRINTS	PR01792. VDCCGAMMA.
ProtoNet	Search...
Other
GenomeRNAi	10368.
NextBio	39299.
SOURCE	Search...

Entry information

Entry name

CCG3_HUMAN

Accession

Primary (citable) accession number: O60359

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	August 1, 1998
Last modified:	April 3, 2013
This is version 105 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.