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Protein

Frizzled-6

Gene

FZD6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear (By similarity).By similarity

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: GO_Central
  2. ubiquitin protein ligase binding Source: UniProtKB
  3. Wnt-activated receptor activity Source: BHF-UCL
  4. Wnt-protein binding Source: BHF-UCL

GO - Biological processi

  1. cell proliferation in midbrain Source: Ensembl
  2. embryonic nail plate morphogenesis Source: Ensembl
  3. establishment of planar polarity Source: Ensembl
  4. hair follicle development Source: Ensembl
  5. inner ear morphogenesis Source: Ensembl
  6. negative regulation of canonical Wnt signaling pathway Source: BHF-UCL
  7. negative regulation of sequence-specific DNA binding transcription factor activity Source: BHF-UCL
  8. neural tube closure Source: Ensembl
  9. non-canonical Wnt signaling pathway Source: BHF-UCL
  10. platelet activation Source: Ensembl
  11. Wnt signaling pathway, planar cell polarity pathway Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_18372. Class B/2 (Secretin family receptors).
REACT_263982. Ca2+ pathway.
REACT_264199. PCP/CE pathway.
REACT_264378. RNF mutants show enhanced WNT signaling and proliferation.
REACT_264580. regulation of FZD by ubiquitination.

Names & Taxonomyi

Protein namesi
Recommended name:
Frizzled-6
Short name:
Fz-6
Short name:
hFz6
Gene namesi
Name:FZD6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:4044. FZD6.

Subcellular locationi

Membrane By similarity; Multi-pass membrane protein Sequence Analysis. Cell membrane By similarity; Multi-pass membrane protein Sequence Analysis. Cell surface By similarity. Apical cell membrane; Multi-pass membrane protein Sequence Analysis. Cytoplasmic vesicle membrane By similarity; Multi-pass membrane protein Sequence Analysis
Note: Colocalizes with FZD3 at the apical face of cells (By similarity).By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 201183ExtracellularSequence AnalysisAdd
BLAST
Transmembranei202 – 22221Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini223 – 23311CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei234 – 25421Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini255 – 28430ExtracellularSequence AnalysisAdd
BLAST
Transmembranei285 – 30521Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini306 – 32419CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei325 – 34521Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini346 – 37025ExtracellularSequence AnalysisAdd
BLAST
Transmembranei371 – 39121Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini392 – 41625CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei417 – 43721Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini438 – 47336ExtracellularSequence AnalysisAdd
BLAST
Transmembranei474 – 49421Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini495 – 706212CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: UniProtKB-SubCell
  2. apicolateral plasma membrane Source: Ensembl
  3. cell surface Source: UniProtKB-SubCell
  4. cytoplasmic vesicle membrane Source: UniProtKB-SubCell
  5. integral component of membrane Source: GO_Central
  6. integral component of plasma membrane Source: BHF-UCL
  7. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Involvement in diseasei

Nail disorder, non-syndromic congenital, 10 (NDNC10)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA nail disorder characterized by a variable degree of onychauxis (thick nails), hyponychia, and onycholysis of all nails, with claw-shaped fingernails in some individuals. No other anomalies of ectodermal tissues, including hair, teeth, sweat glands, or skin, are noted, and individuals with dysplastic nails have normal hearing and normal psychomotor development.

See also OMIM:614157
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti511 – 5111R → C in NDNC10; also found in a patient with neural tube defects; the mutant protein localizes to the lysosomes compared to wild-type. 2 Publications
VAR_066398

Rare non-synonymous variants in FZD6 may contribute to neural tube defects, congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy.

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi614157. phenotype.
Orphaneti280654. Autosomal recessive nail dysplasia.
PharmGKBiPA28461.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 706688Frizzled-6PRO_0000012994Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi24 ↔ 85PROSITE-ProRule annotation
Disulfide bondi32 ↔ 78PROSITE-ProRule annotation
Glycosylationi38 – 381N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi69 ↔ 106PROSITE-ProRule annotation
Disulfide bondi95 ↔ 129PROSITE-ProRule annotation
Disulfide bondi99 ↔ 123PROSITE-ProRule annotation
Glycosylationi352 – 3521N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

MaxQBiO60353.
PaxDbiO60353.
PRIDEiO60353.

PTM databases

PhosphoSiteiO60353.

Expressioni

Tissue specificityi

Detected in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, thymus, prostate, testis, ovary, small intestine and colon. In the fetus, expressed in brain, lung, liver and kidney.

Gene expression databases

BgeeiO60353.
CleanExiHS_FZD6.
ExpressionAtlasiO60353. baseline and differential.
GenevestigatoriO60353.

Organism-specific databases

HPAiHPA017991.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SFRP1Q8N4743EBI-8754490,EBI-3940687

Protein-protein interaction databases

BioGridi113919. 6 interactions.
DIPiDIP-59893N.
IntActiO60353. 1 interaction.
STRINGi9606.ENSP00000351605.

Structurei

3D structure databases

ProteinModelPortaliO60353.
SMRiO60353. Positions 24-126, 178-503.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 132114FZPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi498 – 5036Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family membersBy similarity

Domaini

Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.By similarity
The FZ domain is involved in binding with Wnt ligands.By similarity

Sequence similaritiesi

Contains 1 FZ (frizzled) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG262811.
GeneTreeiENSGT00760000118864.
HOGENOMiHOG000233237.
HOVERGENiHBG006977.
InParanoidiO60353.
KOiK02376.
OMAiKKTCSEW.
OrthoDBiEOG7M3J01.
PhylomeDBiO60353.
TreeFamiTF317907.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026543. FZD6.
IPR017981. GPCR_2-like.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF75. PTHR11309:SF75. 1 hit.
PfamiPF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view]
PRINTSiPR00489. FRIZZLED.
SMARTiSM00063. FRI. 1 hit.
[Graphical view]
SUPFAMiSSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O60353-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEMFTFLLTC IFLPLLRGHS LFTCEPITVP RCMKMAYNMT FFPNLMGHYD
60 70 80 90 100
QSIAAVEMEH FLPLANLECS PNIETFLCKA FVPTCIEQIH VVPPCRKLCE
110 120 130 140 150
KVYSDCKKLI DTFGIRWPEE LECDRLQYCD ETVPVTFDPH TEFLGPQKKT
160 170 180 190 200
EQVQRDIGFW CPRHLKTSGG QGYKFLGIDQ CAPPCPNMYF KSDELEFAKS
210 220 230 240 250
FIGTVSIFCL CATLFTFLTF LIDVRRFRYP ERPIIYYSVC YSIVSLMYFI
260 270 280 290 300
GFLLGDSTAC NKADEKLELG DTVVLGSQNK ACTVLFMLLY FFTMAGTVWW
310 320 330 340 350
VILTITWFLA AGRKWSCEAI EQKAVWFHAV AWGTPGFLTV MLLAMNKVEG
360 370 380 390 400
DNISGVCFVG LYDLDASRYF VLLPLCLCVF VGLSLLLAGI ISLNHVRQVI
410 420 430 440 450
QHDGRNQEKL KKFMIRIGVF SGLYLVPLVT LLGCYVYEQV NRITWEITWV
460 470 480 490 500
SDHCRQYHIP CPYQAKAKAR PELALFMIKY LMTLIVGISA VFWVGSKKTC
510 520 530 540 550
TEWAGFFKRN RKRDPISESR RVLQESCEFF LKHNSKVKHK KKHYKPSSHK
560 570 580 590 600
LKVISKSMGT STGATANHGT SAVAITSHDY LGQETLTEIQ TSPETSMREV
610 620 630 640 650
KADGASTPRL REQDCGEPAS PAASISRLSG EQVDGKGQAG SVSESARSEG
660 670 680 690 700
RISPKSDITD TGLAQSNNLQ VPSSSEPSSL KGSTSLLVHP VSGVRKEQGG

GCHSDT
Length:706
Mass (Da):79,292
Last modified:November 25, 2008 - v2
Checksum:iFBFF5844D6AB0223
GO
Isoform 2 (identifier: O60353-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: Missing.

Show »
Length:674
Mass (Da):75,579
Checksum:i43860DD6918CBBCD
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti33 – 331M → V.2 Publications
Corresponds to variant rs827528 [ dbSNP | Ensembl ].
VAR_047440
Natural varianti140 – 1401H → Y.1 Publication
Corresponds to variant rs80216383 [ dbSNP | Ensembl ].
VAR_066963
Natural varianti152 – 1521Q → E.1 Publication
Corresponds to variant rs61753730 [ dbSNP | Ensembl ].
VAR_066964
Natural varianti345 – 3451M → L.4 Publications
Corresponds to variant rs3808553 [ dbSNP | Ensembl ].
VAR_047441
Natural varianti388 – 3881A → D.1 Publication
Corresponds to variant rs142694816 [ dbSNP | Ensembl ].
VAR_066965
Natural varianti405 – 4051R → Q.1 Publication
Corresponds to variant rs150760762 [ dbSNP | Ensembl ].
VAR_066966
Natural varianti511 – 5111R → C in NDNC10; also found in a patient with neural tube defects; the mutant protein localizes to the lysosomes compared to wild-type. 2 Publications
VAR_066398
Natural varianti511 – 5111R → H in a patient with neural tube defects. 1 Publication
VAR_066967
Natural varianti604 – 6041G → R.1 Publication
Corresponds to variant rs79408516 [ dbSNP | Ensembl ].
VAR_066968
Natural varianti620 – 6201S → T.1 Publication
Corresponds to variant rs116195528 [ dbSNP | Ensembl ].
VAR_066969
Natural varianti664 – 6641A → E.1 Publication
Corresponds to variant rs12549394 [ dbSNP | Ensembl ].
VAR_047442

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3232Missing in isoform 2. 1 PublicationVSP_044291Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012911 mRNA. Translation: BAA25686.1.
AF072873 mRNA. Translation: AAD41637.1.
AF363578 Genomic DNA. Translation: AAL50384.1.
AB065702 Genomic DNA. Translation: BAC05925.1.
AK299341 mRNA. Translation: BAG61342.1.
BX640609 mRNA. Translation: CAE45715.1.
AC025370 Genomic DNA. No translation available.
CH471060 Genomic DNA. Translation: EAW91867.1.
BC060836 mRNA. Translation: AAH60836.2.
CCDSiCCDS55268.1. [O60353-2]
CCDS6298.1. [O60353-1]
PIRiJE0164.
RefSeqiNP_001158087.1. NM_001164615.1. [O60353-1]
NP_001158088.1. NM_001164616.1. [O60353-2]
NP_003497.2. NM_003506.3. [O60353-1]
UniGeneiHs.591863.
Hs.676099.

Genome annotation databases

EnsembliENST00000358755; ENSP00000351605; ENSG00000164930. [O60353-1]
ENST00000522566; ENSP00000429055; ENSG00000164930. [O60353-1]
ENST00000523739; ENSP00000429528; ENSG00000164930. [O60353-2]
GeneIDi8323.
KEGGihsa:8323.
UCSCiuc003ylh.3. human. [O60353-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012911 mRNA. Translation: BAA25686.1.
AF072873 mRNA. Translation: AAD41637.1.
AF363578 Genomic DNA. Translation: AAL50384.1.
AB065702 Genomic DNA. Translation: BAC05925.1.
AK299341 mRNA. Translation: BAG61342.1.
BX640609 mRNA. Translation: CAE45715.1.
AC025370 Genomic DNA. No translation available.
CH471060 Genomic DNA. Translation: EAW91867.1.
BC060836 mRNA. Translation: AAH60836.2.
CCDSiCCDS55268.1. [O60353-2]
CCDS6298.1. [O60353-1]
PIRiJE0164.
RefSeqiNP_001158087.1. NM_001164615.1. [O60353-1]
NP_001158088.1. NM_001164616.1. [O60353-2]
NP_003497.2. NM_003506.3. [O60353-1]
UniGeneiHs.591863.
Hs.676099.

3D structure databases

ProteinModelPortaliO60353.
SMRiO60353. Positions 24-126, 178-503.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113919. 6 interactions.
DIPiDIP-59893N.
IntActiO60353. 1 interaction.
STRINGi9606.ENSP00000351605.

Chemistry

GuidetoPHARMACOLOGYi234.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiO60353.

Proteomic databases

MaxQBiO60353.
PaxDbiO60353.
PRIDEiO60353.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358755; ENSP00000351605; ENSG00000164930. [O60353-1]
ENST00000522566; ENSP00000429055; ENSG00000164930. [O60353-1]
ENST00000523739; ENSP00000429528; ENSG00000164930. [O60353-2]
GeneIDi8323.
KEGGihsa:8323.
UCSCiuc003ylh.3. human. [O60353-1]

Organism-specific databases

CTDi8323.
GeneCardsiGC08P104267.
H-InvDBHIX0201314.
HGNCiHGNC:4044. FZD6.
HPAiHPA017991.
MIMi603409. gene.
614157. phenotype.
neXtProtiNX_O60353.
Orphaneti280654. Autosomal recessive nail dysplasia.
PharmGKBiPA28461.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG262811.
GeneTreeiENSGT00760000118864.
HOGENOMiHOG000233237.
HOVERGENiHBG006977.
InParanoidiO60353.
KOiK02376.
OMAiKKTCSEW.
OrthoDBiEOG7M3J01.
PhylomeDBiO60353.
TreeFamiTF317907.

Enzyme and pathway databases

ReactomeiREACT_18372. Class B/2 (Secretin family receptors).
REACT_263982. Ca2+ pathway.
REACT_264199. PCP/CE pathway.
REACT_264378. RNF mutants show enhanced WNT signaling and proliferation.
REACT_264580. regulation of FZD by ubiquitination.

Miscellaneous databases

GeneWikiiFZD6.
GenomeRNAii8323.
NextBioi31167.
PROiO60353.
SOURCEiSearch...

Gene expression databases

BgeeiO60353.
CleanExiHS_FZD6.
ExpressionAtlasiO60353. baseline and differential.
GenevestigatoriO60353.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026543. FZD6.
IPR017981. GPCR_2-like.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF75. PTHR11309:SF75. 1 hit.
PfamiPF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view]
PRINTSiPR00489. FRIZZLED.
SMARTiSM00063. FRI. 1 hit.
[Graphical view]
SUPFAMiSSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT LEU-345.
    Tissue: Fetal lung.
  2. "Molecular cloning of the human Frizzled 6."
    Gazit A., Yaniv A., Aaronson S.A.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT LEU-345.
  3. "BAALC, the human member of a novel mammalian neuroectoderm gene lineage, is implicated in hematopoiesis and acute leukemia."
    Tanner S.M., Austin J.L., Leone G., Rush L.J., Plass C., Heinonen K., Mrozek K., Sill H., Knuutila S., Kolitz J.E., Archer K.J., Caligiuri M.A., Bloomfield C.D., de La Chapelle A.
    Proc. Natl. Acad. Sci. U.S.A. 98:13901-13906(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT VAL-33.
    Tissue: Uterine endothelium.
  7. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LEU-345.
    Tissue: Placenta.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. Cited for: POSSIBLE INVOLVEMENT IN NEURAL TUBE DEFECTS, VARIANTS VAL-33; TYR-140; GLU-152; LEU-345; ASP-388; GLN-405; CYS-511; HIS-511; ARG-604; THR-620 AND GLU-664.
  12. Cited for: UBIQUITINATION BY ZNRF3.
  13. Cited for: VARIANT NDNC10 CYS-511, CHARACTERIZATION OF VARIANT NDNC10 CYS-511.

Entry informationi

Entry nameiFZD6_HUMAN
AccessioniPrimary (citable) accession number: O60353
Secondary accession number(s): B4DRN0
, Q6N0A5, Q6P9C3, Q8WXR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: November 25, 2008
Last modified: April 1, 2015
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.