Frizzled-6 precursor - Homo sapiens (Human)

Contribute

Send feedback

Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot O60353 (FZD6_HUMAN)

Last modified January 19, 2010. Version 87. History...

Clusters with 100%, 90%, 50% identity |

Documents (6) |

Third-party data |

Customize display

text xml rdf/xml gff fasta

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein names

Recommended name:
    Frizzled-6
      Short name=Fz-6
      Short name=hFz6

Gene names

Name:

FZD6

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Hide | Top

Protein attributes

Sequence length	706 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

Hide | Top

General annotation (Comments)

Function	Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Detected in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, thymus, prostate, testis, ovary, small intestine and colon. In the fetus, expressed in brain, lung, liver and kidney.
Domain	Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway By similarity. The FZ domain is involved in binding with Wnt ligands By similarity.
Sequence similarities	Belongs to the G-protein coupled receptor Fz/Smo family. Contains 1 FZ (frizzled) domain.

Hide | Top

Ontologies

Keywords
Biological process	Wnt signaling pathway
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane
Molecular function	Developmental protein G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW Wnt receptor signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to plasma membrane Ref.1 Traceable author statement. Source: ProtInc
Molecular function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW Wnt receptor activity Ref.1 Traceable author statement. Source: ProtInc non-G-protein coupled 7TM receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Hide | Top

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 18

Potential

Chain

19 – 706

688

Frizzled-6

PRO_0000012994

Regions

Topological domain

19 – 201

183

Extracellular Potential

Transmembrane

202 – 222

1 Potential

Topological domain

223 – 233

Cytoplasmic Potential

Transmembrane

234 – 254

2 Potential

Topological domain

255 – 284

Extracellular Potential

Transmembrane

285 – 305

3 Potential

Topological domain

306 – 324

Cytoplasmic Potential

Transmembrane

325 – 345

4 Potential

Topological domain

346 – 370

Extracellular Potential

Transmembrane

371 – 391

5 Potential

Topological domain

392 – 416

Cytoplasmic Potential

Transmembrane

417 – 437

6 Potential

Topological domain

438 – 473

Extracellular Potential

Transmembrane

474 – 494

7 Potential

Topological domain

495 – 706

212

Cytoplasmic Potential

Domain

19 – 132

114

Motif

498 – 503

Lys-Thr-X-X-X-Trp motif

Amino acid modifications

Modified residue

606

Phosphoserine Ref.8

Modified residue

607

Phosphothreonine Ref.8

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

352

N-linked (GlcNAc...) Potential

Disulfide bond

24 ↔ 85

By similarity

Disulfide bond

32 ↔ 78

By similarity

Disulfide bond

69 ↔ 106

By similarity

Disulfide bond

95 ↔ 129

By similarity

Disulfide bond

99 ↔ 123

By similarity

Natural variations

Natural variant

M → V: dbSNP rs827528. Ref.5

VAR_047440

Natural variant

345

M → L: dbSNP rs3808553. Ref.1 Ref.2 Ref.7

VAR_047441

Natural variant

664

A → E: dbSNP rs12549394.

VAR_047442

Hide | Top

Sequences

Sequence

Length

Mass (Da)

Tools

O60353-1 [UniParc].

Last modified November 25, 2008. Version 2.
Checksum: FBFF5844D6AB0223
Show »

FASTA

706

79,292

        10         20         30         40         50         60 
MEMFTFLLTC IFLPLLRGHS LFTCEPITVP RCMKMAYNMT FFPNLMGHYD QSIAAVEMEH 

        70         80         90        100        110        120 
FLPLANLECS PNIETFLCKA FVPTCIEQIH VVPPCRKLCE KVYSDCKKLI DTFGIRWPEE 

       130        140        150        160        170        180 
LECDRLQYCD ETVPVTFDPH TEFLGPQKKT EQVQRDIGFW CPRHLKTSGG QGYKFLGIDQ 

       190        200        210        220        230        240 
CAPPCPNMYF KSDELEFAKS FIGTVSIFCL CATLFTFLTF LIDVRRFRYP ERPIIYYSVC 

       250        260        270        280        290        300 
YSIVSLMYFI GFLLGDSTAC NKADEKLELG DTVVLGSQNK ACTVLFMLLY FFTMAGTVWW 

       310        320        330        340        350        360 
VILTITWFLA AGRKWSCEAI EQKAVWFHAV AWGTPGFLTV MLLAMNKVEG DNISGVCFVG 

       370        380        390        400        410        420 
LYDLDASRYF VLLPLCLCVF VGLSLLLAGI ISLNHVRQVI QHDGRNQEKL KKFMIRIGVF 

       430        440        450        460        470        480 
SGLYLVPLVT LLGCYVYEQV NRITWEITWV SDHCRQYHIP CPYQAKAKAR PELALFMIKY 

       490        500        510        520        530        540 
LMTLIVGISA VFWVGSKKTC TEWAGFFKRN RKRDPISESR RVLQESCEFF LKHNSKVKHK 

       550        560        570        580        590        600 
KKHYKPSSHK LKVISKSMGT STGATANHGT SAVAITSHDY LGQETLTEIQ TSPETSMREV 

       610        620        630        640        650        660 
KADGASTPRL REQDCGEPAS PAASISRLSG EQVDGKGQAG SVSESARSEG RISPKSDITD 

       670        680        690        700 
TGLAQSNNLQ VPSSSEPSSL KGSTSLLVHP VSGVRKEQGG GCHSDT

« Hide

Hide | Top

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of human frizzled-6." Tokuhara M., Hirai M., Atomi Y., Terada M., Katoh M. Biochem. Biophys. Res. Commun. 243:622-627(1998) [PubMed: 9480858] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT LEU-345. Tissue: Fetal lung.
[2]	"Molecular cloning of the human Frizzled 6." Gazit A., Yaniv A., Aaronson S.A. Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT LEU-345.
[3]	"BAALC, the human member of a novel mammalian neuroectoderm gene lineage, is implicated in hematopoiesis and acute leukemia." Tanner S.M., Austin J.L., Leone G., Rush L.J., Plass C., Heinonen K., Mrozek K., Sill H., Knuutila S., Kolitz J.E., Archer K.J., Caligiuri M.A., Bloomfield C.D., de La Chapelle A. Proc. Natl. Acad. Sci. U.S.A. 98:13901-13906(2001) [PubMed: 11707601] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-33. Tissue: Uterine endothelium.
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-345. Tissue: Placenta.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-606 AND THR-607, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Hide | Top

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB012911 mRNA. Translation: BAA25686.1. AF072873 mRNA. Translation: AAD41637.1. AF363578 Genomic DNA. Translation: AAL50384.1. AB065702 Genomic DNA. Translation: BAC05925.1. BX640609 mRNA. Translation: CAE45715.1. CH471060 Genomic DNA. Translation: EAW91867.1. BC060836 mRNA. Translation: AAH60836.2.
IPI	IPI00020228.
PIR	JE0164.
RefSeq	NP_001158087.1. NP_003497.2.
UniGene	Hs.591863
3D structure databases
SMR	O60353. Positions 23-131.
ModBase	Search...
Protein-protein interaction databases
STRING	O60353.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	O60353.
Genome annotation databases
Ensembl	ENST00000358755; ENSP00000351605; ENSG00000164930; Homo sapiens. [Genome view]
GeneID	8323.
KEGG	hsa:8323.
Organism-specific databases
CTD	8323.
GeneCards	GC08P104379.
H-InvDB	HIX0025535.
HGNC	HGNC:4044. FZD6.
HPA	HPA017991.
MIM	603409. gene.
PharmGKB	PA28461.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG06251.
HOGENOM	HBG447413.
HOVERGEN	O60353.
InParanoid	O60353.
OMA	ITSHDYL.
OrthoDB	EOG92FW2Q.
PhylomeDB	O60353.
Enzyme and pathway databases
Pathway_Interaction_DB	wnt_calcium_pathway. Noncanonical Wnt signaling pathway. wnt_signaling_pathway. Wnt signaling.
Gene expression databases
ArrayExpress	O60353.
Bgee	O60353.
CleanEx	HS_FZD6.
Genevestigator	O60353.
GermOnline	ENSG00000164930. Homo sapiens.
Family and domain databases
InterPro	IPR000539. Frizzled. IPR020067. Frizzled-like_dom. IPR000024. Frizzled_Cys-rich. IPR020068. Frizzled_dom_subgr. IPR015526. Frizzled_related. IPR017981. GPCR_2-like. [Graphical view]
Gene3D	G3DSA:1.10.2000.10. Frizzled_Cys-rich. 1 hit.
PANTHER	PTHR11309. Fz_related. 1 hit.
Pfam	PF01534. Frizzled. 1 hit. PF01392. Fz. 1 hit. [Graphical view]
PRINTS	PR00489. FRIZZLED.
SMART	SM00063. FRI. 1 hit. [Graphical view]
PROSITE	PS50038. FZ. 1 hit. PS50261. G_PROTEIN_RECEP_F2_4. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Hide | Top

Entry information

Entry name

FZD6_HUMAN

Accession

Primary (citable) accession number: O60353
Secondary accession number(s): Q6N0A5, Q6P9C3, Q8WXR9

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 5, 2001
Last sequence update:	November 25, 2008
Last modified:	January 19, 2010
This is version 87 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Hide | Top