Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O60353

- FZD6_HUMAN

UniProt

O60353 - FZD6_HUMAN

Protein

Frizzled-6

Gene

FZD6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 137 (01 Oct 2014)
      Sequence version 2 (25 Nov 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. PDZ domain binding Source: RefGenome
    3. protein binding Source: UniProtKB
    4. ubiquitin protein ligase binding Source: UniProtKB
    5. Wnt-activated receptor activity Source: BHF-UCL
    6. Wnt-protein binding Source: BHF-UCL

    GO - Biological processi

    1. angiogenesis Source: RefGenome
    2. axonogenesis Source: RefGenome
    3. cell proliferation in midbrain Source: RefGenome
    4. establishment of planar polarity Source: RefGenome
    5. gonad development Source: RefGenome
    6. G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger Source: RefGenome
    7. hair follicle development Source: Ensembl
    8. inner ear morphogenesis Source: RefGenome
    9. negative regulation of canonical Wnt signaling pathway Source: BHF-UCL
    10. negative regulation of sequence-specific DNA binding transcription factor activity Source: BHF-UCL
    11. neural tube closure Source: RefGenome
    12. non-canonical Wnt signaling pathway Source: BHF-UCL
    13. platelet activation Source: Ensembl
    14. Wnt signaling pathway, planar cell polarity pathway Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein, G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Wnt signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_172581. PCP/CE pathway.
    REACT_172761. Ca2+ pathway.
    REACT_18372. Class B/2 (Secretin family receptors).
    REACT_200716. regulation of FZD by ubiquitination.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Frizzled-6
    Short name:
    Fz-6
    Short name:
    hFz6
    Gene namesi
    Name:FZD6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:4044. FZD6.

    Subcellular locationi

    GO - Cellular componenti

    1. apical part of cell Source: RefGenome
    2. apicolateral plasma membrane Source: RefGenome
    3. cytoplasm Source: RefGenome
    4. integral component of plasma membrane Source: BHF-UCL
    5. neuron projection membrane Source: RefGenome
    6. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Nail disorder, non-syndromic congenital, 10 (NDNC10) [MIM:614157]: A nail disorder characterized by a variable degree of onychauxis (thick nails), hyponychia, and onycholysis of all nails, with claw-shaped fingernails in some individuals. No other anomalies of ectodermal tissues, including hair, teeth, sweat glands, or skin, are noted, and individuals with dysplastic nails have normal hearing and normal psychomotor development.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti511 – 5111R → C in NDNC10; also found in a patient with neural tube defects; the mutant protein localizes to the lysosomes compared to wild-type. 2 Publications
    VAR_066398
    Rare non-synonymous variants in FZD6 may contribute to neural tube defects, congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy.

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi614157. phenotype.
    Orphaneti280654. Autosomal recessive nail dysplasia.
    PharmGKBiPA28461.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 706688Frizzled-6PRO_0000012994Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi24 ↔ 85PROSITE-ProRule annotation
    Disulfide bondi32 ↔ 78PROSITE-ProRule annotation
    Glycosylationi38 – 381N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi69 ↔ 106PROSITE-ProRule annotation
    Disulfide bondi95 ↔ 129PROSITE-ProRule annotation
    Disulfide bondi99 ↔ 123PROSITE-ProRule annotation
    Glycosylationi352 – 3521N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiO60353.
    PaxDbiO60353.
    PRIDEiO60353.

    PTM databases

    PhosphoSiteiO60353.

    Expressioni

    Tissue specificityi

    Detected in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, thymus, prostate, testis, ovary, small intestine and colon. In the fetus, expressed in brain, lung, liver and kidney.

    Gene expression databases

    ArrayExpressiO60353.
    BgeeiO60353.
    CleanExiHS_FZD6.
    GenevestigatoriO60353.

    Organism-specific databases

    HPAiHPA017991.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    SFRP1Q8N4743EBI-8754490,EBI-3940687

    Protein-protein interaction databases

    BioGridi113919. 3 interactions.
    DIPiDIP-59893N.
    IntActiO60353. 1 interaction.
    STRINGi9606.ENSP00000351605.

    Structurei

    3D structure databases

    ProteinModelPortaliO60353.
    SMRiO60353. Positions 24-126, 178-503.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini19 – 201183ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini223 – 23311CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini255 – 28430ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini306 – 32419CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini346 – 37025ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini392 – 41625CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini438 – 47336ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini495 – 706212CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei202 – 22221Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei234 – 25421Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei285 – 30521Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei325 – 34521Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei371 – 39121Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei417 – 43721Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei474 – 49421Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini19 – 132114FZPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi498 – 5036Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family membersBy similarity

    Domaini

    Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.By similarity
    The FZ domain is involved in binding with Wnt ligands.By similarity

    Sequence similaritiesi

    Contains 1 FZ (frizzled) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG262811.
    HOGENOMiHOG000233237.
    HOVERGENiHBG006977.
    InParanoidiO60353.
    KOiK02376.
    OMAiCPYQAKA.
    OrthoDBiEOG7M3J01.
    PhylomeDBiO60353.
    TreeFamiTF317907.

    Family and domain databases

    Gene3Di1.10.2000.10. 1 hit.
    InterProiIPR000539. Frizzled.
    IPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR026543. FZD6.
    IPR017981. GPCR_2-like.
    [Graphical view]
    PANTHERiPTHR11309. PTHR11309. 1 hit.
    PTHR11309:SF75. PTHR11309:SF75. 1 hit.
    PfamiPF01534. Frizzled. 1 hit.
    PF01392. Fz. 1 hit.
    [Graphical view]
    PRINTSiPR00489. FRIZZLED.
    SMARTiSM00063. FRI. 1 hit.
    [Graphical view]
    SUPFAMiSSF63501. SSF63501. 1 hit.
    PROSITEiPS50038. FZ. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O60353-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEMFTFLLTC IFLPLLRGHS LFTCEPITVP RCMKMAYNMT FFPNLMGHYD    50
    QSIAAVEMEH FLPLANLECS PNIETFLCKA FVPTCIEQIH VVPPCRKLCE 100
    KVYSDCKKLI DTFGIRWPEE LECDRLQYCD ETVPVTFDPH TEFLGPQKKT 150
    EQVQRDIGFW CPRHLKTSGG QGYKFLGIDQ CAPPCPNMYF KSDELEFAKS 200
    FIGTVSIFCL CATLFTFLTF LIDVRRFRYP ERPIIYYSVC YSIVSLMYFI 250
    GFLLGDSTAC NKADEKLELG DTVVLGSQNK ACTVLFMLLY FFTMAGTVWW 300
    VILTITWFLA AGRKWSCEAI EQKAVWFHAV AWGTPGFLTV MLLAMNKVEG 350
    DNISGVCFVG LYDLDASRYF VLLPLCLCVF VGLSLLLAGI ISLNHVRQVI 400
    QHDGRNQEKL KKFMIRIGVF SGLYLVPLVT LLGCYVYEQV NRITWEITWV 450
    SDHCRQYHIP CPYQAKAKAR PELALFMIKY LMTLIVGISA VFWVGSKKTC 500
    TEWAGFFKRN RKRDPISESR RVLQESCEFF LKHNSKVKHK KKHYKPSSHK 550
    LKVISKSMGT STGATANHGT SAVAITSHDY LGQETLTEIQ TSPETSMREV 600
    KADGASTPRL REQDCGEPAS PAASISRLSG EQVDGKGQAG SVSESARSEG 650
    RISPKSDITD TGLAQSNNLQ VPSSSEPSSL KGSTSLLVHP VSGVRKEQGG 700
    GCHSDT 706
    Length:706
    Mass (Da):79,292
    Last modified:November 25, 2008 - v2
    Checksum:iFBFF5844D6AB0223
    GO
    Isoform 2 (identifier: O60353-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-32: Missing.

    Show »
    Length:674
    Mass (Da):75,579
    Checksum:i43860DD6918CBBCD
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti33 – 331M → V.2 Publications
    Corresponds to variant rs827528 [ dbSNP | Ensembl ].
    VAR_047440
    Natural varianti140 – 1401H → Y.1 Publication
    Corresponds to variant rs80216383 [ dbSNP | Ensembl ].
    VAR_066963
    Natural varianti152 – 1521Q → E.1 Publication
    Corresponds to variant rs61753730 [ dbSNP | Ensembl ].
    VAR_066964
    Natural varianti345 – 3451M → L.4 Publications
    Corresponds to variant rs3808553 [ dbSNP | Ensembl ].
    VAR_047441
    Natural varianti388 – 3881A → D.1 Publication
    Corresponds to variant rs142694816 [ dbSNP | Ensembl ].
    VAR_066965
    Natural varianti405 – 4051R → Q.1 Publication
    Corresponds to variant rs150760762 [ dbSNP | Ensembl ].
    VAR_066966
    Natural varianti511 – 5111R → C in NDNC10; also found in a patient with neural tube defects; the mutant protein localizes to the lysosomes compared to wild-type. 2 Publications
    VAR_066398
    Natural varianti511 – 5111R → H in a patient with neural tube defects. 1 Publication
    VAR_066967
    Natural varianti604 – 6041G → R.1 Publication
    Corresponds to variant rs79408516 [ dbSNP | Ensembl ].
    VAR_066968
    Natural varianti620 – 6201S → T.1 Publication
    Corresponds to variant rs116195528 [ dbSNP | Ensembl ].
    VAR_066969
    Natural varianti664 – 6641A → E.1 Publication
    Corresponds to variant rs12549394 [ dbSNP | Ensembl ].
    VAR_047442

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 3232Missing in isoform 2. 1 PublicationVSP_044291Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB012911 mRNA. Translation: BAA25686.1.
    AF072873 mRNA. Translation: AAD41637.1.
    AF363578 Genomic DNA. Translation: AAL50384.1.
    AB065702 Genomic DNA. Translation: BAC05925.1.
    AK299341 mRNA. Translation: BAG61342.1.
    BX640609 mRNA. Translation: CAE45715.1.
    AC025370 Genomic DNA. No translation available.
    CH471060 Genomic DNA. Translation: EAW91867.1.
    BC060836 mRNA. Translation: AAH60836.2.
    CCDSiCCDS55268.1. [O60353-2]
    CCDS6298.1. [O60353-1]
    PIRiJE0164.
    RefSeqiNP_001158087.1. NM_001164615.1. [O60353-1]
    NP_001158088.1. NM_001164616.1. [O60353-2]
    NP_003497.2. NM_003506.3. [O60353-1]
    UniGeneiHs.591863.
    Hs.676099.

    Genome annotation databases

    EnsembliENST00000358755; ENSP00000351605; ENSG00000164930. [O60353-1]
    ENST00000522566; ENSP00000429055; ENSG00000164930. [O60353-1]
    ENST00000523739; ENSP00000429528; ENSG00000164930. [O60353-2]
    GeneIDi8323.
    KEGGihsa:8323.
    UCSCiuc003ylh.3. human. [O60353-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB012911 mRNA. Translation: BAA25686.1 .
    AF072873 mRNA. Translation: AAD41637.1 .
    AF363578 Genomic DNA. Translation: AAL50384.1 .
    AB065702 Genomic DNA. Translation: BAC05925.1 .
    AK299341 mRNA. Translation: BAG61342.1 .
    BX640609 mRNA. Translation: CAE45715.1 .
    AC025370 Genomic DNA. No translation available.
    CH471060 Genomic DNA. Translation: EAW91867.1 .
    BC060836 mRNA. Translation: AAH60836.2 .
    CCDSi CCDS55268.1. [O60353-2 ]
    CCDS6298.1. [O60353-1 ]
    PIRi JE0164.
    RefSeqi NP_001158087.1. NM_001164615.1. [O60353-1 ]
    NP_001158088.1. NM_001164616.1. [O60353-2 ]
    NP_003497.2. NM_003506.3. [O60353-1 ]
    UniGenei Hs.591863.
    Hs.676099.

    3D structure databases

    ProteinModelPortali O60353.
    SMRi O60353. Positions 24-126, 178-503.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113919. 3 interactions.
    DIPi DIP-59893N.
    IntActi O60353. 1 interaction.
    STRINGi 9606.ENSP00000351605.

    Chemistry

    GuidetoPHARMACOLOGYi 234.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei O60353.

    Proteomic databases

    MaxQBi O60353.
    PaxDbi O60353.
    PRIDEi O60353.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000358755 ; ENSP00000351605 ; ENSG00000164930 . [O60353-1 ]
    ENST00000522566 ; ENSP00000429055 ; ENSG00000164930 . [O60353-1 ]
    ENST00000523739 ; ENSP00000429528 ; ENSG00000164930 . [O60353-2 ]
    GeneIDi 8323.
    KEGGi hsa:8323.
    UCSCi uc003ylh.3. human. [O60353-1 ]

    Organism-specific databases

    CTDi 8323.
    GeneCardsi GC08P104267.
    H-InvDB HIX0201314.
    HGNCi HGNC:4044. FZD6.
    HPAi HPA017991.
    MIMi 603409. gene.
    614157. phenotype.
    neXtProti NX_O60353.
    Orphaneti 280654. Autosomal recessive nail dysplasia.
    PharmGKBi PA28461.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG262811.
    HOGENOMi HOG000233237.
    HOVERGENi HBG006977.
    InParanoidi O60353.
    KOi K02376.
    OMAi CPYQAKA.
    OrthoDBi EOG7M3J01.
    PhylomeDBi O60353.
    TreeFami TF317907.

    Enzyme and pathway databases

    Reactomei REACT_172581. PCP/CE pathway.
    REACT_172761. Ca2+ pathway.
    REACT_18372. Class B/2 (Secretin family receptors).
    REACT_200716. regulation of FZD by ubiquitination.

    Miscellaneous databases

    GeneWikii FZD6.
    GenomeRNAii 8323.
    NextBioi 31167.
    PROi O60353.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O60353.
    Bgeei O60353.
    CleanExi HS_FZD6.
    Genevestigatori O60353.

    Family and domain databases

    Gene3Di 1.10.2000.10. 1 hit.
    InterProi IPR000539. Frizzled.
    IPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR026543. FZD6.
    IPR017981. GPCR_2-like.
    [Graphical view ]
    PANTHERi PTHR11309. PTHR11309. 1 hit.
    PTHR11309:SF75. PTHR11309:SF75. 1 hit.
    Pfami PF01534. Frizzled. 1 hit.
    PF01392. Fz. 1 hit.
    [Graphical view ]
    PRINTSi PR00489. FRIZZLED.
    SMARTi SM00063. FRI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF63501. SSF63501. 1 hit.
    PROSITEi PS50038. FZ. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT LEU-345.
      Tissue: Fetal lung.
    2. "Molecular cloning of the human Frizzled 6."
      Gazit A., Yaniv A., Aaronson S.A.
      Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT LEU-345.
    3. "BAALC, the human member of a novel mammalian neuroectoderm gene lineage, is implicated in hematopoiesis and acute leukemia."
      Tanner S.M., Austin J.L., Leone G., Rush L.J., Plass C., Heinonen K., Mrozek K., Sill H., Knuutila S., Kolitz J.E., Archer K.J., Caligiuri M.A., Bloomfield C.D., de La Chapelle A.
      Proc. Natl. Acad. Sci. U.S.A. 98:13901-13906(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT VAL-33.
      Tissue: Uterine endothelium.
    7. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LEU-345.
      Tissue: Placenta.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. Cited for: POSSIBLE INVOLVEMENT IN NEURAL TUBE DEFECTS, VARIANTS VAL-33; TYR-140; GLU-152; LEU-345; ASP-388; GLN-405; CYS-511; HIS-511; ARG-604; THR-620 AND GLU-664.
    12. Cited for: UBIQUITINATION BY ZNRF3.
    13. Cited for: VARIANT NDNC10 CYS-511, CHARACTERIZATION OF VARIANT NDNC10 CYS-511.

    Entry informationi

    Entry nameiFZD6_HUMAN
    AccessioniPrimary (citable) accession number: O60353
    Secondary accession number(s): B4DRN0
    , Q6N0A5, Q6P9C3, Q8WXR9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 5, 2001
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 137 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3