Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O60353 (FZD6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 132. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Frizzled-6

Short name=Fz-6
Short name=hFz6
Gene names
Name:FZD6
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length706 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

Subcellular location

Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein By similarity.

Tissue specificity

Detected in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, thymus, prostate, testis, ovary, small intestine and colon. In the fetus, expressed in brain, lung, liver and kidney.

Domain

Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway By similarity.

The FZ domain is involved in binding with Wnt ligands By similarity.

Post-translational modification

Ubiquitinated by ZNRF3, leading to its degradation by the proteasome By similarity. Ref.12

Involvement in disease

Nail disorder, non-syndromic congenital, 10 (NDNC10) [MIM:614157]: A nail disorder characterized by a variable degree of onychauxis (thick nails), hyponychia, and onycholysis of all nails, with claw-shaped fingernails in some individuals. No other anomalies of ectodermal tissues, including hair, teeth, sweat glands, or skin, are noted, and individuals with dysplastic nails have normal hearing and normal psychomotor development.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.13

Rare non-synonymous variants in FZD6 may contribute to neural tube defects, congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy.

Sequence similarities

Belongs to the G-protein coupled receptor Fz/Smo family.

Contains 1 FZ (frizzled) domain.

Ontologies

Keywords
   Biological processWnt signaling pathway
   Cellular componentCell membrane
Membrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DiseaseDisease mutation
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionDevelopmental protein
G-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
Ubl conjugation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger

Inferred from Biological aspect of Ancestor. Source: RefGenome

Wnt signaling pathway, planar cell polarity pathway

Inferred from electronic annotation. Source: Ensembl

angiogenesis

Inferred from Biological aspect of Ancestor. Source: RefGenome

axonogenesis

Inferred from Biological aspect of Ancestor. Source: RefGenome

cell proliferation in midbrain

Inferred from Biological aspect of Ancestor. Source: RefGenome

establishment of planar polarity

Inferred from Biological aspect of Ancestor. Source: RefGenome

gonad development

Inferred from Biological aspect of Ancestor. Source: RefGenome

hair follicle development

Inferred from electronic annotation. Source: Ensembl

inner ear morphogenesis

Inferred from Biological aspect of Ancestor. Source: RefGenome

negative regulation of canonical Wnt signaling pathway

Inferred from mutant phenotype PubMed 14747478. Source: BHF-UCL

negative regulation of sequence-specific DNA binding transcription factor activity

Inferred from direct assay PubMed 14747478. Source: BHF-UCL

neural tube closure

Inferred from Biological aspect of Ancestor. Source: RefGenome

non-canonical Wnt signaling pathway

Inferred from direct assay PubMed 14747478. Source: BHF-UCL

platelet activation

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentapical part of cell

Inferred from Biological aspect of Ancestor. Source: RefGenome

apicolateral plasma membrane

Inferred from Biological aspect of Ancestor. Source: RefGenome

cytoplasm

Inferred from Biological aspect of Ancestor. Source: RefGenome

integral component of plasma membrane

Inferred from sequence or structural similarity PubMed 15265686. Source: BHF-UCL

neuron projection membrane

Inferred from Biological aspect of Ancestor. Source: RefGenome

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionG-protein coupled receptor activity

Inferred from electronic annotation. Source: UniProtKB-KW

PDZ domain binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

Wnt-activated receptor activity

Inferred from direct assay PubMed 10347172. Source: BHF-UCL

Wnt-protein binding

Inferred from sequence or structural similarity PubMed 15265686. Source: BHF-UCL

ubiquitin protein ligase binding

Inferred from physical interaction Ref.12. Source: UniProtKB

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

SFRP1Q8N4743EBI-8754490,EBI-3940687

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O60353-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O60353-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 706688Frizzled-6
PRO_0000012994

Regions

Topological domain19 – 201183Extracellular Potential
Transmembrane202 – 22221Helical; Name=1; Potential
Topological domain223 – 23311Cytoplasmic Potential
Transmembrane234 – 25421Helical; Name=2; Potential
Topological domain255 – 28430Extracellular Potential
Transmembrane285 – 30521Helical; Name=3; Potential
Topological domain306 – 32419Cytoplasmic Potential
Transmembrane325 – 34521Helical; Name=4; Potential
Topological domain346 – 37025Extracellular Potential
Transmembrane371 – 39121Helical; Name=5; Potential
Topological domain392 – 41625Cytoplasmic Potential
Transmembrane417 – 43721Helical; Name=6; Potential
Topological domain438 – 47336Extracellular Potential
Transmembrane474 – 49421Helical; Name=7; Potential
Topological domain495 – 706212Cytoplasmic Potential
Domain19 – 132114FZ
Motif498 – 5036Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members By similarity

Amino acid modifications

Glycosylation381N-linked (GlcNAc...) Potential
Glycosylation3521N-linked (GlcNAc...) Potential
Disulfide bond24 ↔ 85 By similarity
Disulfide bond32 ↔ 78 By similarity
Disulfide bond69 ↔ 106 By similarity
Disulfide bond95 ↔ 129 By similarity
Disulfide bond99 ↔ 123 By similarity

Natural variations

Alternative sequence1 – 3232Missing in isoform 2.
VSP_044291
Natural variant331M → V. Ref.6 Ref.11
Corresponds to variant rs827528 [ dbSNP | Ensembl ].
VAR_047440
Natural variant1401H → Y. Ref.11
Corresponds to variant rs80216383 [ dbSNP | Ensembl ].
VAR_066963
Natural variant1521Q → E. Ref.11
Corresponds to variant rs61753730 [ dbSNP | Ensembl ].
VAR_066964
Natural variant3451M → L. Ref.1 Ref.2 Ref.9 Ref.11
Corresponds to variant rs3808553 [ dbSNP | Ensembl ].
VAR_047441
Natural variant3881A → D. Ref.11
Corresponds to variant rs142694816 [ dbSNP | Ensembl ].
VAR_066965
Natural variant4051R → Q. Ref.11
Corresponds to variant rs150760762 [ dbSNP | Ensembl ].
VAR_066966
Natural variant5111R → C in NDNC10; also found in a patient with neural tube defects; the mutant protein localizes to the lysosomes compared to wild-type. Ref.11 Ref.13
VAR_066398
Natural variant5111R → H in a patient with neural tube defects. Ref.11
VAR_066967
Natural variant6041G → R. Ref.11
Corresponds to variant rs79408516 [ dbSNP | Ensembl ].
VAR_066968
Natural variant6201S → T. Ref.11
Corresponds to variant rs116195528 [ dbSNP | Ensembl ].
VAR_066969
Natural variant6641A → E. Ref.11
Corresponds to variant rs12549394 [ dbSNP | Ensembl ].
VAR_047442

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 25, 2008. Version 2.
Checksum: FBFF5844D6AB0223

FASTA70679,292
        10         20         30         40         50         60 
MEMFTFLLTC IFLPLLRGHS LFTCEPITVP RCMKMAYNMT FFPNLMGHYD QSIAAVEMEH 

        70         80         90        100        110        120 
FLPLANLECS PNIETFLCKA FVPTCIEQIH VVPPCRKLCE KVYSDCKKLI DTFGIRWPEE 

       130        140        150        160        170        180 
LECDRLQYCD ETVPVTFDPH TEFLGPQKKT EQVQRDIGFW CPRHLKTSGG QGYKFLGIDQ 

       190        200        210        220        230        240 
CAPPCPNMYF KSDELEFAKS FIGTVSIFCL CATLFTFLTF LIDVRRFRYP ERPIIYYSVC 

       250        260        270        280        290        300 
YSIVSLMYFI GFLLGDSTAC NKADEKLELG DTVVLGSQNK ACTVLFMLLY FFTMAGTVWW 

       310        320        330        340        350        360 
VILTITWFLA AGRKWSCEAI EQKAVWFHAV AWGTPGFLTV MLLAMNKVEG DNISGVCFVG 

       370        380        390        400        410        420 
LYDLDASRYF VLLPLCLCVF VGLSLLLAGI ISLNHVRQVI QHDGRNQEKL KKFMIRIGVF 

       430        440        450        460        470        480 
SGLYLVPLVT LLGCYVYEQV NRITWEITWV SDHCRQYHIP CPYQAKAKAR PELALFMIKY 

       490        500        510        520        530        540 
LMTLIVGISA VFWVGSKKTC TEWAGFFKRN RKRDPISESR RVLQESCEFF LKHNSKVKHK 

       550        560        570        580        590        600 
KKHYKPSSHK LKVISKSMGT STGATANHGT SAVAITSHDY LGQETLTEIQ TSPETSMREV 

       610        620        630        640        650        660 
KADGASTPRL REQDCGEPAS PAASISRLSG EQVDGKGQAG SVSESARSEG RISPKSDITD 

       670        680        690        700 
TGLAQSNNLQ VPSSSEPSSL KGSTSLLVHP VSGVRKEQGG GCHSDT 

« Hide

Isoform 2 [UniParc].

Checksum: 43860DD6918CBBCD
Show »

FASTA67475,579

References

« Hide 'large scale' references
[1]"Molecular cloning of human frizzled-6."
Tokuhara M., Hirai M., Atomi Y., Terada M., Katoh M.
Biochem. Biophys. Res. Commun. 243:622-627(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT LEU-345.
Tissue: Fetal lung.
[2]"Molecular cloning of the human Frizzled 6."
Gazit A., Yaniv A., Aaronson S.A.
Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT LEU-345.
[3]"BAALC, the human member of a novel mammalian neuroectoderm gene lineage, is implicated in hematopoiesis and acute leukemia."
Tanner S.M., Austin J.L., Leone G., Rush L.J., Plass C., Heinonen K., Mrozek K., Sill H., Knuutila S., Kolitz J.E., Archer K.J., Caligiuri M.A., Bloomfield C.D., de La Chapelle A.
Proc. Natl. Acad. Sci. U.S.A. 98:13901-13906(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[6]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT VAL-33.
Tissue: Uterine endothelium.
[7]"DNA sequence and analysis of human chromosome 8."
Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. expand/collapse author list , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LEU-345.
Tissue: Placenta.
[10]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[11]"FZD6 is a novel gene for human neural tube defects."
De Marco P., Merello E., Rossi A., Piatelli G., Cama A., Kibar Z., Capra V.
Hum. Mutat. 33:384-390(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: POSSIBLE INVOLVEMENT IN NEURAL TUBE DEFECTS, VARIANTS VAL-33; TYR-140; GLU-152; LEU-345; ASP-388; GLN-405; CYS-511; HIS-511; ARG-604; THR-620 AND GLU-664.
[12]"ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner."
Hao H.X., Xie Y., Zhang Y., Charlat O., Oster E., Avello M., Lei H., Mickanin C., Liu D., Ruffner H., Mao X., Ma Q., Zamponi R., Bouwmeester T., Finan P.M., Kirschner M.W., Porter J.A., Serluca F.C., Cong F.
Nature 485:195-200(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: UBIQUITINATION BY ZNRF3.
[13]"Mutations in Frizzled 6 cause isolated autosomal-recessive nail dysplasia."
Frojmark A.S., Schuster J., Sobol M., Entesarian M., Kilander M.B., Gabrikova D., Nawaz S., Baig S.M., Schulte G., Klar J., Dahl N.
Am. J. Hum. Genet. 88:852-860(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT NDNC10 CYS-511, CHARACTERIZATION OF VARIANT NDNC10 CYS-511.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB012911 mRNA. Translation: BAA25686.1.
AF072873 mRNA. Translation: AAD41637.1.
AF363578 Genomic DNA. Translation: AAL50384.1.
AB065702 Genomic DNA. Translation: BAC05925.1.
AK299341 mRNA. Translation: BAG61342.1.
BX640609 mRNA. Translation: CAE45715.1.
AC025370 Genomic DNA. No translation available.
CH471060 Genomic DNA. Translation: EAW91867.1.
BC060836 mRNA. Translation: AAH60836.2.
PIRJE0164.
RefSeqNP_001158087.1. NM_001164615.1.
NP_001158088.1. NM_001164616.1.
NP_003497.2. NM_003506.3.
UniGeneHs.591863.
Hs.676099.

3D structure databases

ProteinModelPortalO60353.
SMRO60353. Positions 24-126, 178-503.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113919. 3 interactions.
DIPDIP-59893N.
IntActO60353. 1 interaction.
STRING9606.ENSP00000351605.

Chemistry

GuidetoPHARMACOLOGY234.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteO60353.

Proteomic databases

PaxDbO60353.
PRIDEO60353.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000358755; ENSP00000351605; ENSG00000164930. [O60353-1]
ENST00000522566; ENSP00000429055; ENSG00000164930. [O60353-1]
ENST00000523739; ENSP00000429528; ENSG00000164930. [O60353-2]
GeneID8323.
KEGGhsa:8323.
UCSCuc003ylh.3. human. [O60353-1]

Organism-specific databases

CTD8323.
GeneCardsGC08P104267.
H-InvDBHIX0201314.
HGNCHGNC:4044. FZD6.
HPAHPA017991.
MIM603409. gene.
614157. phenotype.
neXtProtNX_O60353.
Orphanet280654. Autosomal recessive nail dysplasia.
PharmGKBPA28461.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG262811.
HOGENOMHOG000233237.
HOVERGENHBG006977.
InParanoidO60353.
KOK02376.
OMAFDPHTEF.
OrthoDBEOG7M3J01.
PhylomeDBO60353.
TreeFamTF317907.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressO60353.
BgeeO60353.
CleanExHS_FZD6.
GenevestigatorO60353.

Family and domain databases

Gene3D1.10.2000.10. 1 hit.
InterProIPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026543. FZD6.
IPR017981. GPCR_2-like.
[Graphical view]
PANTHERPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF21. PTHR11309:SF21. 1 hit.
PfamPF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view]
PRINTSPR00489. FRIZZLED.
SMARTSM00063. FRI. 1 hit.
[Graphical view]
SUPFAMSSF63501. SSF63501. 1 hit.
PROSITEPS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiFZD6.
GenomeRNAi8323.
NextBio31167.
PROO60353.
SOURCESearch...

Entry information

Entry nameFZD6_HUMAN
AccessionPrimary (citable) accession number: O60353
Secondary accession number(s): B4DRN0 expand/collapse secondary AC list , Q6N0A5, Q6P9C3, Q8WXR9
Entry history
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: November 25, 2008
Last modified: April 16, 2014
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries