O60353 (FZD6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Frizzled-6
Short name=Fz-6
Short name=hFz6

Gene names

Name:

FZD6

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	706 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
Subcellular location	Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein By similarity.
Tissue specificity	Detected in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, thymus, prostate, testis, ovary, small intestine and colon. In the fetus, expressed in brain, lung, liver and kidney.
Domain	Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway By similarity. The FZ domain is involved in binding with Wnt ligands By similarity.
Post-translational modification	Ubiquitinated by ZNRF3, leading to its degradation by the proteasome By similarity. Ref.12
Involvement in disease	Nail disorder, non-syndromic congenital, 10 (NDNC10) [MIM:614157]: A nail disorder characterized by a variable degree of onychauxis (thick nails), hyponychia, and onycholysis of all nails, with claw-shaped fingernails in some individuals. No other anomalies of ectodermal tissues, including hair, teeth, sweat glands, or skin, are noted, and individuals with dysplastic nails have normal hearing and normal psychomotor development. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.13 Rare non-synonymous variants in FZD6 may contribute to neural tube defects, congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy.
Sequence similarities	Belongs to the G-protein coupled receptor Fz/Smo family. Contains 1 FZ (frizzled) domain.

Ontologies

Keywords
Biological process	Wnt signaling pathway
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Disease mutation
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Developmental protein G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger Inferred from Biological aspect of Ancestor. Source: RefGenome Wnt receptor signaling pathway, planar cell polarity pathway Inferred from electronic annotation. Source: Compara angiogenesis Inferred from Biological aspect of Ancestor. Source: RefGenome axonogenesis Inferred from Biological aspect of Ancestor. Source: RefGenome cell proliferation in midbrain Inferred from Biological aspect of Ancestor. Source: RefGenome establishment of planar polarity Inferred from Biological aspect of Ancestor. Source: RefGenome gonad development Inferred from Biological aspect of Ancestor. Source: RefGenome hair follicle development Inferred from electronic annotation. Source: Compara inner ear morphogenesis Inferred from Biological aspect of Ancestor. Source: RefGenome negative regulation of canonical Wnt receptor signaling pathway Inferred from mutant phenotype PubMed 14747478. Source: BHF-UCL negative regulation of sequence-specific DNA binding transcription factor activity Inferred from direct assay PubMed 14747478. Source: BHF-UCL neural tube closure Inferred from Biological aspect of Ancestor. Source: RefGenome non-canonical Wnt receptor signaling pathway Inferred from direct assay PubMed 14747478. Source: BHF-UCL platelet activation Inferred from electronic annotation. Source: Compara
Cellular_component	apical part of cell Inferred from Biological aspect of Ancestor. Source: RefGenome apicolateral plasma membrane Inferred from Biological aspect of Ancestor. Source: RefGenome cytoplasm Inferred from Biological aspect of Ancestor. Source: RefGenome integral to plasma membrane Inferred from sequence or structural similarity PubMed 15265686. Source: BHF-UCL neuron projection membrane Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW PDZ domain binding Inferred from Biological aspect of Ancestor. Source: RefGenome Wnt-activated receptor activity Inferred from direct assay PubMed 10347172. Source: BHF-UCL Wnt-protein binding Inferred from sequence or structural similarity PubMed 15265686. Source: BHF-UCL
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O60353-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O60353-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 706	688	Frizzled-6		PRO_0000012994
Regions
	Topological domain	19 – 201	183	Extracellular Potential
	Transmembrane	202 – 222	21	Helical; Name=1; Potential
	Topological domain	223 – 233	11	Cytoplasmic Potential
	Transmembrane	234 – 254	21	Helical; Name=2; Potential
	Topological domain	255 – 284	30	Extracellular Potential
	Transmembrane	285 – 305	21	Helical; Name=3; Potential
	Topological domain	306 – 324	19	Cytoplasmic Potential
	Transmembrane	325 – 345	21	Helical; Name=4; Potential
	Topological domain	346 – 370	25	Extracellular Potential
	Transmembrane	371 – 391	21	Helical; Name=5; Potential
	Topological domain	392 – 416	25	Cytoplasmic Potential
	Transmembrane	417 – 437	21	Helical; Name=6; Potential
	Topological domain	438 – 473	36	Extracellular Potential
	Transmembrane	474 – 494	21	Helical; Name=7; Potential
	Topological domain	495 – 706	212	Cytoplasmic Potential
	Domain	19 – 132	114	FZ
	Motif	498 – 503	6	Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members By similarity
Amino acid modifications
	Glycosylation	38	1	N-linked (GlcNAc...) Potential
	Glycosylation	352	1	N-linked (GlcNAc...) Potential
	Disulfide bond	24 ↔ 85		By similarity
	Disulfide bond	32 ↔ 78		By similarity
	Disulfide bond	69 ↔ 106		By similarity
	Disulfide bond	95 ↔ 129		By similarity
	Disulfide bond	99 ↔ 123		By similarity
Natural variations
	Alternative sequence	1 – 32	32	Missing in isoform 2.		VSP_044291
	Natural variant	33	1	M → V. Ref.6 Ref.11 Corresponds to variant rs827528 [ dbSNP | Ensembl ].		VAR_047440
	Natural variant	140	1	H → Y. Ref.11 Corresponds to variant rs80216383 [ dbSNP | Ensembl ].		VAR_066963
	Natural variant	152	1	Q → E. Ref.11 Corresponds to variant rs61753730 [ dbSNP | Ensembl ].		VAR_066964
	Natural variant	345	1	M → L. Ref.1 Ref.2 Ref.9 Ref.11 Corresponds to variant rs3808553 [ dbSNP | Ensembl ].		VAR_047441
	Natural variant	388	1	A → D. Ref.11 Corresponds to variant rs142694816 [ dbSNP | Ensembl ].		VAR_066965
	Natural variant	405	1	R → Q. Ref.11 Corresponds to variant rs150760762 [ dbSNP | Ensembl ].		VAR_066966
	Natural variant	511	1	R → C in NDNC10; also found in a patient with neural tube defects; the mutant protein localizes to the lysosomes compared to wild-type. Ref.11 Ref.13		VAR_066398
	Natural variant	511	1	R → H in a patient with neural tube defects. Ref.11		VAR_066967
	Natural variant	604	1	G → R. Ref.11 Corresponds to variant rs79408516 [ dbSNP | Ensembl ].		VAR_066968
	Natural variant	620	1	S → T. Ref.11 Corresponds to variant rs116195528 [ dbSNP | Ensembl ].		VAR_066969
	Natural variant	664	1	A → E. Ref.11 Corresponds to variant rs12549394 [ dbSNP | Ensembl ].		VAR_047442

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 25, 2008. Version 2. Checksum: FBFF5844D6AB0223	FASTA	706	79,292
	10 20 30 40 50 60 MEMFTFLLTC IFLPLLRGHS LFTCEPITVP RCMKMAYNMT FFPNLMGHYD QSIAAVEMEH 70 80 90 100 110 120 FLPLANLECS PNIETFLCKA FVPTCIEQIH VVPPCRKLCE KVYSDCKKLI DTFGIRWPEE 130 140 150 160 170 180 LECDRLQYCD ETVPVTFDPH TEFLGPQKKT EQVQRDIGFW CPRHLKTSGG QGYKFLGIDQ 190 200 210 220 230 240 CAPPCPNMYF KSDELEFAKS FIGTVSIFCL CATLFTFLTF LIDVRRFRYP ERPIIYYSVC 250 260 270 280 290 300 YSIVSLMYFI GFLLGDSTAC NKADEKLELG DTVVLGSQNK ACTVLFMLLY FFTMAGTVWW 310 320 330 340 350 360 VILTITWFLA AGRKWSCEAI EQKAVWFHAV AWGTPGFLTV MLLAMNKVEG DNISGVCFVG 370 380 390 400 410 420 LYDLDASRYF VLLPLCLCVF VGLSLLLAGI ISLNHVRQVI QHDGRNQEKL KKFMIRIGVF 430 440 450 460 470 480 SGLYLVPLVT LLGCYVYEQV NRITWEITWV SDHCRQYHIP CPYQAKAKAR PELALFMIKY 490 500 510 520 530 540 LMTLIVGISA VFWVGSKKTC TEWAGFFKRN RKRDPISESR RVLQESCEFF LKHNSKVKHK 550 560 570 580 590 600 KKHYKPSSHK LKVISKSMGT STGATANHGT SAVAITSHDY LGQETLTEIQ TSPETSMREV 610 620 630 640 650 660 KADGASTPRL REQDCGEPAS PAASISRLSG EQVDGKGQAG SVSESARSEG RISPKSDITD 670 680 690 700 TGLAQSNNLQ VPSSSEPSSL KGSTSLLVHP VSGVRKEQGG GCHSDT
	Isoform 2 [UniParc]. Checksum: 43860DD6918CBBCD	FASTA	674	75,579
	10 20 30 40 50 60 MKMAYNMTFF PNLMGHYDQS IAAVEMEHFL PLANLECSPN IETFLCKAFV PTCIEQIHVV 70 80 90 100 110 120 PPCRKLCEKV YSDCKKLIDT FGIRWPEELE CDRLQYCDET VPVTFDPHTE FLGPQKKTEQ 130 140 150 160 170 180 VQRDIGFWCP RHLKTSGGQG YKFLGIDQCA PPCPNMYFKS DELEFAKSFI GTVSIFCLCA 190 200 210 220 230 240 TLFTFLTFLI DVRRFRYPER PIIYYSVCYS IVSLMYFIGF LLGDSTACNK ADEKLELGDT 250 260 270 280 290 300 VVLGSQNKAC TVLFMLLYFF TMAGTVWWVI LTITWFLAAG RKWSCEAIEQ KAVWFHAVAW 310 320 330 340 350 360 GTPGFLTVML LAMNKVEGDN ISGVCFVGLY DLDASRYFVL LPLCLCVFVG LSLLLAGIIS 370 380 390 400 410 420 LNHVRQVIQH DGRNQEKLKK FMIRIGVFSG LYLVPLVTLL GCYVYEQVNR ITWEITWVSD 430 440 450 460 470 480 HCRQYHIPCP YQAKAKARPE LALFMIKYLM TLIVGISAVF WVGSKKTCTE WAGFFKRNRK 490 500 510 520 530 540 RDPISESRRV LQESCEFFLK HNSKVKHKKK HYKPSSHKLK VISKSMGTST GATANHGTSA 550 560 570 580 590 600 VAITSHDYLG QETLTEIQTS PETSMREVKA DGASTPRLRE QDCGEPASPA ASISRLSGEQ 610 620 630 640 650 660 VDGKGQAGSV SESARSEGRI SPKSDITDTG LAQSNNLQVP SSSEPSSLKG STSLLVHPVS 670 GVRKEQGGGC HSDT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of human frizzled-6." Tokuhara M., Hirai M., Atomi Y., Terada M., Katoh M. Biochem. Biophys. Res. Commun. 243:622-627(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT LEU-345. Tissue: Fetal lung.
[2]	"Molecular cloning of the human Frizzled 6." Gazit A., Yaniv A., Aaronson S.A. Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT LEU-345.
[3]	"BAALC, the human member of a novel mammalian neuroectoderm gene lineage, is implicated in hematopoiesis and acute leukemia." Tanner S.M., Austin J.L., Leone G., Rush L.J., Plass C., Heinonen K., Mrozek K., Sill H., Knuutila S., Kolitz J.E., Archer K.J., Caligiuri M.A., Bloomfield C.D., de La Chapelle A. Proc. Natl. Acad. Sci. U.S.A. 98:13901-13906(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[6]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT VAL-33. Tissue: Uterine endothelium.
[7]	"DNA sequence and analysis of human chromosome 8." Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S. Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LEU-345. Tissue: Placenta.
[10]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[11]	"FZD6 is a novel gene for human neural tube defects." De Marco P., Merello E., Rossi A., Piatelli G., Cama A., Kibar Z., Capra V. Hum. Mutat. 33:384-390(2012) [PubMed] [Europe PMC] [Abstract] Cited for: POSSIBLE INVOLVEMENT IN NEURAL TUBE DEFECTS, VARIANTS VAL-33; TYR-140; GLU-152; LEU-345; ASP-388; GLN-405; CYS-511; HIS-511; ARG-604; THR-620 AND GLU-664.
[12]	"ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner." Hao H.X., Xie Y., Zhang Y., Charlat O., Oster E., Avello M., Lei H., Mickanin C., Liu D., Ruffner H., Mao X., Ma Q., Zamponi R., Bouwmeester T., Finan P.M., Kirschner M.W., Porter J.A., Serluca F.C., Cong F. Nature 485:195-200(2012) [PubMed] [Europe PMC] [Abstract] Cited for: UBIQUITINATION BY ZNRF3.
[13]	"Mutations in Frizzled 6 cause isolated autosomal-recessive nail dysplasia." Frojmark A.S., Schuster J., Sobol M., Entesarian M., Kilander M.B., Gabrikova D., Nawaz S., Baig S.M., Schulte G., Klar J., Dahl N. Am. J. Hum. Genet. 88:852-860(2011) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT NDNC10 CYS-511, CHARACTERIZATION OF VARIANT NDNC10 CYS-511.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB012911 mRNA. Translation: BAA25686.1. AF072873 mRNA. Translation: AAD41637.1. AF363578 Genomic DNA. Translation: AAL50384.1. AB065702 Genomic DNA. Translation: BAC05925.1. AK299341 mRNA. Translation: BAG61342.1. BX640609 mRNA. Translation: CAE45715.1. AC025370 Genomic DNA. No translation available. CH471060 Genomic DNA. Translation: EAW91867.1. BC060836 mRNA. Translation: AAH60836.2.
IPI	IPI00020228.
PIR	JE0164.
RefSeq	NP_001158087.1. NM_001164615.1. NP_001158088.1. NM_001164616.1. NP_003497.2. NM_003506.3.
UniGene	Hs.591863.
3D structure databases
ProteinModelPortal	O60353.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-59893N.
STRING	9606.ENSP00000351605.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	O60353.
Proteomic databases
PaxDb	O60353.
PRIDE	O60353.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000358755; ENSP00000351605; ENSG00000164930. ENST00000522566; ENSP00000429055; ENSG00000164930. ENST00000523739; ENSP00000429528; ENSG00000164930.
GeneID	8323.
KEGG	hsa:8323.
UCSC	uc003ylh.3. human.
Organism-specific databases
CTD	8323.
GeneCards	GC08P104267.
H-InvDB	HIX0201314.
HGNC	HGNC:4044. FZD6.
HPA	HPA017991.
MIM	603409. gene. 614157. phenotype.
neXtProt	NX_O60353.
Orphanet	280654. Autosomal recessive nail dysplasia.
PharmGKB	PA28461.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG262811.
HOGENOM	HOG000233237.
HOVERGEN	HBG006977.
InParanoid	O60353.
KO	K02376.
OMA	CPYQAKA.
OrthoDB	EOG4QC153.
PhylomeDB	O60353.
Enzyme and pathway databases
Pathway_Interaction_DB	wnt_calcium_pathway. Noncanonical Wnt signaling pathway. wnt_signaling_pathway. Wnt signaling.
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	O60353.
Bgee	O60353.
CleanEx	HS_FZD6.
Genevestigator	O60353.
GermOnline	ENSG00000164930. Homo sapiens.
Family and domain databases
Gene3D	1.10.2000.10. 1 hit.
InterPro	IPR000539. Frizzled. IPR015526. Frizzled/SFRP. IPR020067. Frizzled_dom. IPR026543. FZD6. IPR017981. GPCR_2-like. [Graphical view]
PANTHER	PTHR11309. PTHR11309. 1 hit. PTHR11309:SF21. PTHR11309:SF21. 1 hit.
Pfam	PF01534. Frizzled. 1 hit. PF01392. Fz. 1 hit. [Graphical view]
PRINTS	PR00489. FRIZZLED.
SMART	SM00063. FRI. 1 hit. [Graphical view]
SUPFAM	SSF63501. Frizzled_Cys-rich. 1 hit.
PROSITE	PS50038. FZ. 1 hit. PS50261. G_PROTEIN_RECEP_F2_4. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	8323.
NextBio	31167.
SOURCE	Search...

Entry information

Entry name

FZD6_HUMAN

Accession

Primary (citable) accession number: O60353
Secondary accession number(s): B4DRN0 , Q6N0A5, Q6P9C3, Q8WXR9

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 5, 2001
Last sequence update:	November 25, 2008
Last modified:	May 1, 2013
This is version 122 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.