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Protein

TBC1 domain family member 12

Gene

TBC1D12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May act as a GTPase-activating protein for Rab family protein(s).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
TBC1 domain family member 12
Gene namesi
Name:TBC1D12
Synonyms:KIAA0608
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:29082. TBC1D12.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134891743.

Polymorphism and mutation databases

BioMutaiTBC1D12.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 775775TBC1 domain family member 12PRO_0000208037Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources
Modified residuei284 – 2841PhosphoserineBy similarity
Modified residuei315 – 3151PhosphoserineCombined sources
Modified residuei747 – 7471PhosphoserineCombined sources
Modified residuei748 – 7481PhosphothreonineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO60347.
MaxQBiO60347.
PaxDbiO60347.
PeptideAtlasiO60347.
PRIDEiO60347.

PTM databases

iPTMnetiO60347.
PhosphoSiteiO60347.

Expressioni

Gene expression databases

BgeeiO60347.
CleanExiHS_TBC1D12.
GenevisibleiO60347. HS.

Organism-specific databases

HPAiHPA038277.
HPA038645.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116837. 1 interaction.
IntActiO60347. 1 interaction.
STRINGi9606.ENSP00000225235.

Structurei

3D structure databases

ProteinModelPortaliO60347.
SMRiO60347. Positions 454-760.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini484 – 692209Rab-GAP TBCPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili409 – 45244Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 Rab-GAP TBC domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2223. Eukaryota.
COG5210. LUCA.
GeneTreeiENSGT00750000117238.
HOGENOMiHOG000016604.
HOVERGENiHBG061665.
InParanoidiO60347.
OMAiEDPLRSC.
OrthoDBiEOG786H3R.
PhylomeDBiO60347.
TreeFamiTF313318.

Family and domain databases

InterProiIPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
PROSITEiPS50086. TBC_RABGAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O60347-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGPEDAGAC SGRNPKLLPV PAPDPVGQDR KVIRATGGFG GGVGAVEPPE
60 70 80 90 100
EADEEEEADE EEETPPRQLL QRYLAAAGEQ LEPGLCYCPL PAGQAGAPPP
110 120 130 140 150
SAAPRSDACL LGSGSKHRGA EVADGRAPRH EGMTNGDSGF LPGRDCRDLE
160 170 180 190 200
EARGLARAGG RESRRRRPYG RLRLEGPGDE DADGAGSPSD WASPLEDPLR
210 220 230 240 250
SCCLVAADAQ EPEGAGSDSG DSPASSCSSS EDSEQRGVGA GGPEEGAPPA
260 270 280 290 300
TSAERTNGGA EPRLGFSDIH FNSRNTFQVS RGQSARDHLP PAGPPVPLPA
310 320 330 340 350
AEQGPAGASA RARRSGGFAD FFTRNLFPKR TKELKSVVHS APGWKLFGKV
360 370 380 390 400
PPRENLQKTS KIIQQEYEAR TGRTCKPPPQ SSRRKNFEFE PLSTTALILE
410 420 430 440 450
DRPSNLPAKS VEEALRHRQE YDEMVAEAKK REIKEAHKRK RIMKERFKQE
460 470 480 490 500
ENIASAMVIW INEILPNWEV MRSTRRVREL WWQGLPPSVR GKVWSLAVGN
510 520 530 540 550
ELNITPELYE IFLSRAKERW KSFSETSSEN DTEGVSVADR EASLELIKLD
560 570 580 590 600
ISRTFPSLYI FQKGGPYHDV LHSILGAYTC YRPDVGYVQG MSFIAAVLIL
610 620 630 640 650
NLEEADAFIA FANLLNKPCQ LAFFRVDHSM MLKYFATFEV FFEENLSKLF
660 670 680 690 700
LHFKSYSLTP DIYLIDWIFT LYSKSLPLDL ACRVWDVFCR DGEEFLFRTG
710 720 730 740 750
LGILRLYEDI LLQMDFIHIA QFLTKLPEDI TSEKLFSCIA AIQMQNSTKK
760 770
WTQVFASVMK DIKEGDKNSS PALKS
Length:775
Mass (Da):85,626
Last modified:October 3, 2006 - v3
Checksum:i106CD6E788C4C44E
GO

Sequence cautioni

The sequence BAA25534.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAB43225.2 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti51 – 566Missing in BAA25534 (PubMed:9628581).Curated
Sequence conflicti357 – 3571Q → G in CAB43225 (PubMed:17974005).Curated
Sequence conflicti447 – 4471F → Y in CAB43225 (PubMed:17974005).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011180 mRNA. Translation: BAA25534.1. Different initiation.
AL138759, AL355341 Genomic DNA. Translation: CAH70223.2.
AL355341, AL138759 Genomic DNA. Translation: CAH70583.2.
AL049956 mRNA. Translation: CAB43225.2. Different initiation.
CCDSiCCDS41553.1.
PIRiT08683.
RefSeqiNP_056003.1. NM_015188.1.
UniGeneiHs.500598.

Genome annotation databases

EnsembliENST00000225235; ENSP00000225235; ENSG00000108239.
GeneIDi23232.
KEGGihsa:23232.
UCSCiuc001kjr.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011180 mRNA. Translation: BAA25534.1. Different initiation.
AL138759, AL355341 Genomic DNA. Translation: CAH70223.2.
AL355341, AL138759 Genomic DNA. Translation: CAH70583.2.
AL049956 mRNA. Translation: CAB43225.2. Different initiation.
CCDSiCCDS41553.1.
PIRiT08683.
RefSeqiNP_056003.1. NM_015188.1.
UniGeneiHs.500598.

3D structure databases

ProteinModelPortaliO60347.
SMRiO60347. Positions 454-760.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116837. 1 interaction.
IntActiO60347. 1 interaction.
STRINGi9606.ENSP00000225235.

PTM databases

iPTMnetiO60347.
PhosphoSiteiO60347.

Polymorphism and mutation databases

BioMutaiTBC1D12.

Proteomic databases

EPDiO60347.
MaxQBiO60347.
PaxDbiO60347.
PeptideAtlasiO60347.
PRIDEiO60347.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000225235; ENSP00000225235; ENSG00000108239.
GeneIDi23232.
KEGGihsa:23232.
UCSCiuc001kjr.3. human.

Organism-specific databases

CTDi23232.
GeneCardsiTBC1D12.
HGNCiHGNC:29082. TBC1D12.
HPAiHPA038277.
HPA038645.
neXtProtiNX_O60347.
PharmGKBiPA134891743.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2223. Eukaryota.
COG5210. LUCA.
GeneTreeiENSGT00750000117238.
HOGENOMiHOG000016604.
HOVERGENiHBG061665.
InParanoidiO60347.
OMAiEDPLRSC.
OrthoDBiEOG786H3R.
PhylomeDBiO60347.
TreeFamiTF313318.

Miscellaneous databases

ChiTaRSiTBC1D12. human.
GenomeRNAii23232.
PROiO60347.

Gene expression databases

BgeeiO60347.
CleanExiHS_TBC1D12.
GenevisibleiO60347. HS.

Family and domain databases

InterProiIPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
PROSITEiPS50086. TBC_RABGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 357-775.
    Tissue: Fetal brain.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-315, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-747 AND THR-748, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-315, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma and Erythroleukemia.

Entry informationi

Entry nameiTBC12_HUMAN
AccessioniPrimary (citable) accession number: O60347
Secondary accession number(s): Q5VYA6
, Q8WX26, Q8WX59, Q9UG83
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2004
Last sequence update: October 3, 2006
Last modified: July 6, 2016
This is version 119 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.