##gff-version 3 O60346 UniProtKB Chain 1 1717 . . . ID=PRO_0000057781;Note=PH domain leucine-rich repeat-containing protein phosphatase 1 O60346 UniProtKB Domain 536 636 . . . Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145 O60346 UniProtKB Repeat 638 659 . . . Note=LRR 1 O60346 UniProtKB Repeat 661 682 . . . Note=LRR 2 O60346 UniProtKB Repeat 692 712 . . . Note=LRR 3 O60346 UniProtKB Repeat 715 736 . . . Note=LRR 4 O60346 UniProtKB Repeat 738 760 . . . Note=LRR 5 O60346 UniProtKB Repeat 761 783 . . . Note=LRR 6 O60346 UniProtKB Repeat 784 804 . . . Note=LRR 7 O60346 UniProtKB Repeat 808 831 . . . Note=LRR 8 O60346 UniProtKB Repeat 832 853 . . . Note=LRR 9 O60346 UniProtKB Repeat 873 894 . . . Note=LRR 10 O60346 UniProtKB Repeat 895 916 . . . Note=LRR 11 O60346 UniProtKB Repeat 918 939 . . . Note=LRR 12 O60346 UniProtKB Repeat 941 962 . . . Note=LRR 13 O60346 UniProtKB Repeat 963 984 . . . Note=LRR 14 O60346 UniProtKB Repeat 987 1008 . . . Note=LRR 15 O60346 UniProtKB Repeat 1013 1033 . . . Note=LRR 16 O60346 UniProtKB Repeat 1037 1058 . . . Note=LRR 17 O60346 UniProtKB Repeat 1061 1082 . . . Note=LRR 18 O60346 UniProtKB Repeat 1084 1105 . . . Note=LRR 19 O60346 UniProtKB Repeat 1106 1127 . . . Note=LRR 20 O60346 UniProtKB Repeat 1129 1150 . . . Note=LRR 21 O60346 UniProtKB Domain 1175 1422 . . . Note=PPM-type phosphatase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01082 O60346 UniProtKB Region 1 25 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O60346 UniProtKB Region 41 118 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O60346 UniProtKB Region 136 156 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O60346 UniProtKB Region 252 470 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O60346 UniProtKB Region 1076 1205 . . . Note=Interaction with NHERF1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21804599;Dbxref=PMID:21804599 O60346 UniProtKB Region 1458 1510 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O60346 UniProtKB Region 1673 1717 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O60346 UniProtKB Motif 1715 1717 . . . Note=PDZ-binding%3B required for interaction with NHERF1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21804599;Dbxref=PMID:21804599 O60346 UniProtKB Compositional bias 258 281 . . . Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O60346 UniProtKB Compositional bias 288 305 . . . Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O60346 UniProtKB Compositional bias 346 381 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O60346 UniProtKB Compositional bias 393 410 . . . Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O60346 UniProtKB Compositional bias 1464 1494 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O60346 UniProtKB Binding site 1210 1210 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35813 O60346 UniProtKB Binding site 1210 1210 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35813 O60346 UniProtKB Binding site 1211 1211 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35813 O60346 UniProtKB Binding site 1374 1374 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35813 O60346 UniProtKB Binding site 1413 1413 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35813 O60346 UniProtKB Modified residue 1 1 . . . Note=N-acetylmethionine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22814378;Dbxref=PMID:22814378 O60346 UniProtKB Modified residue 317 317 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 O60346 UniProtKB Modified residue 412 412 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 O60346 UniProtKB Alternative sequence 1 512 . . . ID=VSP_057809;Note=In isoform 2. Missing O60346 UniProtKB Natural variant 1118 1118 . . . ID=VAR_056725;Note=S->T;Dbxref=dbSNP:rs9950585 O60346 UniProtKB Mutagenesis 1715 1717 . . . Note=Loss of function in vivo%2C but does not abolishes intrinsic phosphatase activity. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15808505;Dbxref=PMID:15808505 O60346 UniProtKB Sequence conflict 691 691 . . . Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 O60346 UniProtKB Sequence conflict 1062 1062 . . . Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305 O60346 UniProtKB Sequence conflict 1083 1083 . . . Note=R->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 O60346 UniProtKB Sequence conflict 1227 1227 . . . Note=D->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 O60346 UniProtKB Sequence conflict 1490 1490 . . . Note=V->M;Ontology_term=ECO:0000305;evidence=ECO:0000305 O60346 UniProtKB Sequence conflict 1580 1580 . . . Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305