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Protein

PH domain leucine-rich repeat-containing protein phosphatase 1

Gene

PHLPP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA (PubMed:15808505, PubMed:17386267, PubMed:18162466). Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation (PubMed:18162466). Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor (PubMed:19079341). Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). May act as a negative regulator of K-Ras signaling in membrane rafts (By similarity). Involved in the hippocampus-dependent long-term memory formation (By similarity). Involved in circadian control by regulating the consolidation of circadian periodicity after resetting (By similarity). Involved in development and function of regulatory T-cells (By similarity).By similarity6 Publications

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.2 Publications

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit (By similarity). Mn2+ is inhibitory below pH 8 and activating above pH 8 (PubMed:24892992).By similarity1 Publication

Enzyme regulationi

Insensitive to okadaic acid.1 Publication

Kineticsi

  1. KM=1.5 mM for p-nitrophenyl phosphate1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Metal bindingi1210Manganese 1By similarity1
    Metal bindingi1210Manganese 2By similarity1
    Metal bindingi1211Manganese 1; via carbonyl oxygenBy similarity1
    Metal bindingi1374Manganese 2By similarity1
    Metal bindingi1413Manganese 2By similarity1

    GO - Molecular functioni

    GO - Biological processi

    • apoptotic process Source: UniProtKB-KW
    • entrainment of circadian clock Source: Ensembl
    • negative regulation of protein kinase B signaling Source: UniProtKB
    • regulation of apoptotic process Source: UniProtKB
    • regulation of JNK cascade Source: UniProtKB
    • regulation of MAPK cascade Source: UniProtKB
    • regulation of p38MAPK cascade Source: UniProtKB
    • regulation of T cell anergy Source: Ensembl
    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    Apoptosis

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciZFISH:HS01406-MONOMER.
    ReactomeiR-HSA-199418. Negative regulation of the PI3K/AKT network.
    SIGNORiO60346.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    PH domain leucine-rich repeat-containing protein phosphatase 1 (EC:3.1.3.16)
    Alternative name(s):
    Pleckstrin homology domain-containing family E member 1
    Short name:
    PH domain-containing family E member 1
    Suprachiasmatic nucleus circadian oscillatory protein
    Short name:
    hSCOP
    Gene namesi
    Name:PHLPP1
    Synonyms:KIAA0606, PHLPP, PLEKHE1, SCOP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:20610. PHLPP1.

    Subcellular locationi

    Isoform 2 :

    GO - Cellular componenti

    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Mutagenesisi1715 – 1717Missing : Loss of function in vivo, but does not abolishes intrinsic phosphatase activity. 1 Publication3

    Keywords - Diseasei

    Tumor suppressor

    Organism-specific databases

    DisGeNETi23239.
    OpenTargetsiENSG00000081913.
    PharmGKBiPA165429055.

    Chemistry databases

    ChEMBLiCHEMBL3414405.

    Polymorphism and mutation databases

    BioMutaiPHLPP1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00000577811 – 1717PH domain leucine-rich repeat-containing protein phosphatase 1Add BLAST1717

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Modified residuei1N-acetylmethionineCombined sources1
    Modified residuei317PhosphoserineCombined sources1
    Modified residuei412PhosphoserineCombined sources1

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    EPDiO60346.
    MaxQBiO60346.
    PaxDbiO60346.
    PeptideAtlasiO60346.
    PRIDEiO60346.

    PTM databases

    DEPODiO60346.
    iPTMnetiO60346.
    PhosphoSitePlusiO60346.

    Expressioni

    Tissue specificityi

    In colorectal cancer tissue, expression is highest in the surface epithelium of normal colonic mucosa adjacent to the cancer tissue but is largely excluded from the crypt bases. Expression is lost or significantly decreased in 78% of tested tumors (at protein level). Ubiquitously expressed in non-cancerous tissues.2 Publications

    Gene expression databases

    BgeeiENSG00000081913.
    CleanExiHS_PHLPP.
    ExpressionAtlasiO60346. baseline and differential.
    GenevisibleiO60346. HS.

    Organism-specific databases

    HPAiHPA020200.

    Interactioni

    Subunit structurei

    Interacts with the nucleotide free form of K-Ras (KRAS) via its LRR repeats (By similarity). Interacts with AKT2, AKT3, PRKCB isoform beta-II, STK4, RPS6KB1, RAF1 (PubMed:17386267, PubMed:18162466, PubMed:19732725, PubMed:21986499, PubMed:24530606). Isoform 1 (predominantly) and isoform 2 interact with BRAP (PubMed:25820252). Interacts with FKBP5; FKBP5 acts as a scaffold for PHLPP1 and Akt (PubMed:19732725). Interacts with SCRIB; SCRIB acts as a scaffold for PHLPP1 and Akt (PubMed:21701506). Interacts with SLC9A3R1; SLC9A3R1 scaffolds a heterotrimeric complex with PTEN at the plasma membrane (PubMed:21804599).By similarity9 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PRKCBP05771-25EBI-2511516,EBI-5774511
    SCRIBQ141602EBI-2511516,EBI-357345
    ScribQ80U722EBI-2511516,EBI-1766028From a different organism.
    SLC9A3R1O147455EBI-11165225,EBI-349787

    Protein-protein interaction databases

    BioGridi116843. 33 interactors.
    IntActiO60346. 31 interactors.
    MINTiMINT-2796653.
    STRINGi9606.ENSP00000262719.

    Chemistry databases

    BindingDBiO60346.

    Structurei

    3D structure databases

    ProteinModelPortaliO60346.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Domaini536 – 636PHPROSITE-ProRule annotationAdd BLAST101
    Repeati638 – 659LRR 1Add BLAST22
    Repeati661 – 682LRR 2Add BLAST22
    Repeati692 – 712LRR 3Add BLAST21
    Repeati715 – 736LRR 4Add BLAST22
    Repeati738 – 760LRR 5Add BLAST23
    Repeati761 – 783LRR 6Add BLAST23
    Repeati784 – 804LRR 7Add BLAST21
    Repeati808 – 831LRR 8Add BLAST24
    Repeati832 – 853LRR 9Add BLAST22
    Repeati873 – 894LRR 10Add BLAST22
    Repeati895 – 916LRR 11Add BLAST22
    Repeati918 – 939LRR 12Add BLAST22
    Repeati941 – 962LRR 13Add BLAST22
    Repeati963 – 984LRR 14Add BLAST22
    Repeati987 – 1008LRR 15Add BLAST22
    Repeati1013 – 1033LRR 16Add BLAST21
    Repeati1037 – 1058LRR 17Add BLAST22
    Repeati1061 – 1082LRR 18Add BLAST22
    Repeati1084 – 1105LRR 19Add BLAST22
    Repeati1106 – 1127LRR 20Add BLAST22
    Repeati1129 – 1150LRR 21Add BLAST22
    Domaini1175 – 1422PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST248

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Regioni1076 – 1205Interaction with SLC9A3R11 PublicationAdd BLAST130

    Motif

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Motifi1715 – 1717PDZ-binding; required for interaction with SLC9A3R11 Publication3

    Compositional bias

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Compositional biasi4 – 7Poly-Ala4
    Compositional biasi21 – 45Poly-AlaAdd BLAST25
    Compositional biasi132 – 137Poly-Ala6
    Compositional biasi138 – 144Poly-Ser7
    Compositional biasi145 – 148Poly-Ala4
    Compositional biasi254 – 257Poly-Ala4
    Compositional biasi463 – 469Poly-Pro7
    Compositional biasi1682 – 1689Poly-Gln8

    Domaini

    The PH domain is required for interaction with PRKCB and its dephosphorylation.

    Sequence similaritiesi

    Contains 21 LRR (leucine-rich) repeats.Curated
    Contains 1 PH domain.PROSITE-ProRule annotation
    Contains 1 PPM-type phosphatase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Leucine-rich repeat, Repeat

    Phylogenomic databases

    eggNOGiKOG0619. Eukaryota.
    COG0631. LUCA.
    COG4886. LUCA.
    GeneTreeiENSGT00440000037833.
    InParanoidiO60346.
    KOiK16340.
    OMAiFTNGSRV.
    OrthoDBiEOG091G03A3.
    PhylomeDBiO60346.
    TreeFamiTF315993.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    3.60.40.10. 1 hit.
    3.80.10.10. 4 hits.
    InterProiIPR032675. L_dom-like.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR011993. PH_dom-like.
    IPR001849. PH_domain.
    IPR001932. PPM-type_phosphatase_dom.
    [Graphical view]
    PfamiPF13516. LRR_6. 2 hits.
    PF13855. LRR_8. 2 hits.
    PF00169. PH. 1 hit.
    PF00481. PP2C. 1 hit.
    [Graphical view]
    SMARTiSM00369. LRR_TYP. 10 hits.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50729. SSF50729. 2 hits.
    SSF52058. SSF52058. 2 hits.
    SSF81606. SSF81606. 1 hit.
    PROSITEiPS51450. LRR. 17 hits.
    PS50003. PH_DOMAIN. 1 hit.
    PS51746. PPM_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

    Isoform 1 (identifier: O60346-1) [UniParc]FASTAAdd to basket
    Also known as: beta

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

            10         20         30         40         50
    MEPAAAATVQ RLPELGREDR ASAPAAAAAA AAAAAAAAAA LAAAAGGGRS
    60 70 80 90 100
    PEPALTPAAP SGGNGSGSGA REEAPGEAPP GPLPGRAGGA GRRRRRGAPQ
    110 120 130 140 150
    PIAGGAAPVP GAGGGANSLL LRRGRLKRNL SAAAAAASSS SSSSAAAASH
    160 170 180 190 200
    SPGAAGLPAS CSASASLCTR SLDRKTLLLK HRQTLQLQPS DRDWVRHQLQ
    210 220 230 240 250
    RGCVHVFDRH MASTYLRPVL CTLDTTAGEV AARLLQLGHK GGGVVKVLGQ
    260 270 280 290 300
    GPGAAAAREP AEPPPEAGPR LAPPEPRDSE VPPARSAPGA FGGPPRAPPA
    310 320 330 340 350
    DLPLPVGGPG GWSRRASPAP SDSSPGEPFV GGPVSSPRAP RPVVSDTESF
    360 370 380 390 400
    SLSPSAESVS DRLDPYSSGG GSSSSSEELE ADAASAPTGV PGQPRRPGHP
    410 420 430 440 450
    AQPLPLPQTA SSPQPQQKAP RAIDSPGGAV REGSCEEKAA AAVAPGGLQS
    460 470 480 490 500
    TPGRSGVTAE KAPPPPPPPT LYVQLHGETT RRLEAEEKPL QIQNDYLFQL
    510 520 530 540 550
    GFGELWRVQE EGMDSEIGCL IRFYAGKPHS TGSSERIQLS GMYNVRKGKM
    560 570 580 590 600
    QLPVNRWTRR QVILCGTCLI VSSVKDSLTG KMHVLPLIGG KVEEVKKHQH
    610 620 630 640 650
    CLAFSSSGPQ SQTYYICFDT FTEYLRWLRQ VSKVASQRIS SVDLSCCSLE
    660 670 680 690 700
    HLPANLFYSQ DLTHLNLKQN FLRQNPSLPA ARGLNELQRF TKLKSLNLSN
    710 720 730 740 750
    NHLGDFPLAV CSIPTLAELN VSCNALRSVP AAVGVMHNLQ TFLLDGNFLQ
    760 770 780 790 800
    SLPAELENMK QLSYLGLSFN EFTDIPEVLE KLTAVDKLCM SGNCVETLRL
    810 820 830 840 850
    QALRKMPHIK HVDLRLNVIR KLIADEVDFL QHVTQLDLRD NKLGDLDAMI
    860 870 880 890 900
    FNNIEVLHCE RNQLVTLDIC GYFLKALYAS SNELVQLDVY PVPNYLSYMD
    910 920 930 940 950
    VSRNRLENVP EWVCESRKLE VLDIGHNQIC ELPARLFCNS SLRKLLAGHN
    960 970 980 990 1000
    QLARLPERLE RTSVEVLDVQ HNQLLELPPN LLMKADSLRF LNASANKLES
    1010 1020 1030 1040 1050
    LPPATLSEET NSILQELYLT NNSLTDKCVP LLTGHPHLKI LHMAYNRLQS
    1060 1070 1080 1090 1100
    FPASKMAKLE ELEEIDLSGN KLKAIPTTIM NCRRMHTVIA HSNCIEVFPE
    1110 1120 1130 1140 1150
    VMQLPEIKCV DLSCNELSEV TLPENLPPKL QELDLTGNPR LVLDHKTLEL
    1160 1170 1180 1190 1200
    LNNIRCFKID QPSTGDASGA PAVWSHGYTE ASGVKNKLCV AALSVNNFCD
    1210 1220 1230 1240 1250
    NREALYGVFD GDRNVEVPYL LQCTMSDILA EELQKTKNEE EYMVNTFIVM
    1260 1270 1280 1290 1300
    QRKLGTAGQK LGGAAVLCHI KHDPVDPGGS FTLTSANVGK CQTVLCRNGK
    1310 1320 1330 1340 1350
    PLPLSRSYIM SCEEELKRIK QHKAIITEDG KVNGVTESTR ILGYTFLHPS
    1360 1370 1380 1390 1400
    VVPRPHVQSV LLTPQDEFFI LGSKGLWDSL SVEEAVEAVR NVPDALAAAK
    1410 1420 1430 1440 1450
    KLCTLAQSYG CHDSISAVVV QLSVTEDSFC CCELSAGGAV PPPSPGIFPP
    1460 1470 1480 1490 1500
    SVNMVIKDRP SDGLGVPSSS SGMASEISSE LSTSEMSSEV GSTASDEPPP
    1510 1520 1530 1540 1550
    GALSENSPAY PSEQRCMLHP ICLSNSFQRQ LSSATFSSAF SDNGLDSDDE
    1560 1570 1580 1590 1600
    EPIEGVFTNG SRVEVEVDIH CSRAKEKEKQ QHLLQVPAEA SDEGIVISAN
    1610 1620 1630 1640 1650
    EDEPGLPRKA DFSAVGTIGR RRANGSVAPQ ERSHNVIEVA TDAPLRKPGG
    1660 1670 1680 1690 1700
    YFAAPAQPDP DDQFIIPPEL EEEVKEIMKH HQEQQQQQQP PPPPQLQPQL
    1710
    PRHYQLDQLP DYYDTPL
    Length:1,717
    Mass (Da):184,672
    Last modified:June 7, 2005 - v3
    Checksum:iA4AB53F334EA8AB6
    GO
    Isoform 2 (identifier: O60346-2) [UniParc]FASTAAdd to basket
    Also known as: alpha

    The sequence of this isoform differs from the canonical sequence as follows:
         1-512: Missing.

    Show »
    Length:1,205
    Mass (Da):133,565
    Checksum:iCDBECB2FDA9C7064
    GO

    Sequence cautioni

    The sequence AAH14927 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
    The sequence AAH82244 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
    The sequence AAI26278 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
    The sequence BAA91980 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sequence conflicti691T → A in BAA91980 (PubMed:14702039).Curated1
    Sequence conflicti1062L → F in AAH47653 (PubMed:15489334).Curated1
    Sequence conflicti1083R → S in BAA25532 (PubMed:9628581).Curated1
    Sequence conflicti1227D → V in BAA91980 (PubMed:14702039).Curated1
    Sequence conflicti1490V → M in AAH47653 (PubMed:15489334).Curated1
    Sequence conflicti1580Missing in AAH63519 (PubMed:15489334).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_0567251118S → T.Corresponds to variant rs9950585dbSNPEnsembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Alternative sequenceiVSP_0578091 – 512Missing in isoform 2. Add BLAST512

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AC015989 Genomic DNA. No translation available.
    AC022046 Genomic DNA. No translation available.
    AC027553 Genomic DNA. No translation available.
    AB011178 mRNA. Translation: BAA25532.2.
    BC010706 mRNA. Translation: AAH10706.1.
    BC014927 mRNA. Translation: AAH14927.3. Different initiation.
    BC047653 mRNA. Translation: AAH47653.1.
    BC063519 mRNA. Translation: AAH63519.1.
    BC082244 mRNA. Translation: AAH82244.1. Sequence problems.
    BC126277 mRNA. Translation: AAI26278.1. Different initiation.
    AK001924 mRNA. Translation: BAA91980.1. Different initiation.
    CCDSiCCDS45881.2. [O60346-1]
    PIRiT00258.
    RefSeqiNP_919431.2. NM_194449.3. [O60346-1]
    UniGeneiHs.465337.

    Genome annotation databases

    EnsembliENST00000262719; ENSP00000262719; ENSG00000081913. [O60346-1]
    GeneIDi23239.
    KEGGihsa:23239.
    UCSCiuc021ule.2. human. [O60346-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AC015989 Genomic DNA. No translation available.
    AC022046 Genomic DNA. No translation available.
    AC027553 Genomic DNA. No translation available.
    AB011178 mRNA. Translation: BAA25532.2.
    BC010706 mRNA. Translation: AAH10706.1.
    BC014927 mRNA. Translation: AAH14927.3. Different initiation.
    BC047653 mRNA. Translation: AAH47653.1.
    BC063519 mRNA. Translation: AAH63519.1.
    BC082244 mRNA. Translation: AAH82244.1. Sequence problems.
    BC126277 mRNA. Translation: AAI26278.1. Different initiation.
    AK001924 mRNA. Translation: BAA91980.1. Different initiation.
    CCDSiCCDS45881.2. [O60346-1]
    PIRiT00258.
    RefSeqiNP_919431.2. NM_194449.3. [O60346-1]
    UniGeneiHs.465337.

    3D structure databases

    ProteinModelPortaliO60346.
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi116843. 33 interactors.
    IntActiO60346. 31 interactors.
    MINTiMINT-2796653.
    STRINGi9606.ENSP00000262719.

    Chemistry databases

    BindingDBiO60346.
    ChEMBLiCHEMBL3414405.

    PTM databases

    DEPODiO60346.
    iPTMnetiO60346.
    PhosphoSitePlusiO60346.

    Polymorphism and mutation databases

    BioMutaiPHLPP1.

    Proteomic databases

    EPDiO60346.
    MaxQBiO60346.
    PaxDbiO60346.
    PeptideAtlasiO60346.
    PRIDEiO60346.

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000262719; ENSP00000262719; ENSG00000081913. [O60346-1]
    GeneIDi23239.
    KEGGihsa:23239.
    UCSCiuc021ule.2. human. [O60346-1]

    Organism-specific databases

    CTDi23239.
    DisGeNETi23239.
    GeneCardsiPHLPP1.
    H-InvDBHIX0014494.
    HIX0174202.
    HGNCiHGNC:20610. PHLPP1.
    HPAiHPA020200.
    MIMi609396. gene.
    neXtProtiNX_O60346.
    OpenTargetsiENSG00000081913.
    PharmGKBiPA165429055.
    HUGEiSearch...
    GenAtlasiSearch...

    Phylogenomic databases

    eggNOGiKOG0619. Eukaryota.
    COG0631. LUCA.
    COG4886. LUCA.
    GeneTreeiENSGT00440000037833.
    InParanoidiO60346.
    KOiK16340.
    OMAiFTNGSRV.
    OrthoDBiEOG091G03A3.
    PhylomeDBiO60346.
    TreeFamiTF315993.

    Enzyme and pathway databases

    BioCyciZFISH:HS01406-MONOMER.
    ReactomeiR-HSA-199418. Negative regulation of the PI3K/AKT network.
    SIGNORiO60346.

    Miscellaneous databases

    ChiTaRSiPHLPP1. human.
    GeneWikiiPHLPP_(gene).
    GenomeRNAii23239.
    PROiO60346.
    SOURCEiSearch...

    Gene expression databases

    BgeeiENSG00000081913.
    CleanExiHS_PHLPP.
    ExpressionAtlasiO60346. baseline and differential.
    GenevisibleiO60346. HS.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    3.60.40.10. 1 hit.
    3.80.10.10. 4 hits.
    InterProiIPR032675. L_dom-like.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR011993. PH_dom-like.
    IPR001849. PH_domain.
    IPR001932. PPM-type_phosphatase_dom.
    [Graphical view]
    PfamiPF13516. LRR_6. 2 hits.
    PF13855. LRR_8. 2 hits.
    PF00169. PH. 1 hit.
    PF00481. PP2C. 1 hit.
    [Graphical view]
    SMARTiSM00369. LRR_TYP. 10 hits.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50729. SSF50729. 2 hits.
    SSF52058. SSF52058. 2 hits.
    SSF81606. SSF81606. 1 hit.
    PROSITEiPS51450. LRR. 17 hits.
    PS50003. PH_DOMAIN. 1 hit.
    PS51746. PPM_2. 1 hit.
    [Graphical view]
    ProtoNetiSearch...

    Entry informationi

    Entry nameiPHLP1_HUMAN
    AccessioniPrimary (citable) accession number: O60346
    Secondary accession number(s): A1A4F5
    , Q641Q7, Q6P4C4, Q6PJI6, Q86TN6, Q96FK2, Q9NUY1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2005
    Last sequence update: June 7, 2005
    Last modified: November 30, 2016
    This is version 159 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.