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Protein

Endothelin-converting enzyme 2

Gene

ECE2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May limit beta-amyloid peptide accumulation in brain. May also have methyltransferase activity.1 Publication

Catalytic activityi

Hydrolysis of the 21-Trp-|-Val-22 bond in big endothelin to form endothelin 1.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Kineticsi

  1. KM=0.4 µM for big ET-11 Publication
  2. KM=1.4 µM for peptide E1 Publication
  3. KM=27.4 µM for bradykinin1 Publication
  4. KM=48.4 µM for dynorphin B1 Publication

    pH dependencei

    Optimum pH is 5.0-5.5. Inactive at neutral pH.1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Binding sitei30S-adenosyl-L-homocysteine1 Publication1
    Binding sitei41S-adenosyl-L-homocysteine; via amide nitrogen1 Publication1
    Binding sitei66S-adenosyl-L-homocysteine; via carbonyl oxygen1 Publication1
    Binding sitei130S-adenosyl-L-homocysteine1 Publication1
    Metal bindingi720Zinc; catalyticPROSITE-ProRule annotation1
    Active sitei721PROSITE-ProRule annotation1
    Metal bindingi724Zinc; catalyticPROSITE-ProRule annotation1
    Metal bindingi780Zinc; catalyticPROSITE-ProRule annotation1
    Active sitei784Proton donorPROSITE-ProRule annotation1

    GO - Molecular functioni

    • metal ion binding Source: UniProtKB-KW
    • metalloendopeptidase activity Source: UniProtKB
    • methyltransferase activity Source: UniProtKB-KW

    GO - Biological processi

    • brain development Source: UniProtKB
    • cardioblast differentiation Source: UniProtKB
    • cell-cell signaling Source: UniProtKB
    • heart development Source: UniProtKB
    • peptide hormone processing Source: UniProtKB
    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Methyltransferase, Protease, Transferase

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciZFISH:HS07232-MONOMER.
    SABIO-RKO60344.

    Protein family/group databases

    MEROPSiM13.003.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endothelin-converting enzyme 2
    Short name:
    ECE-2
    Including the following 2 domains:
    Methyltransferase-like region (EC:2.1.1.-)
    Endothelin-converting enzyme 2 region (EC:3.4.24.71)
    Gene namesi
    Name:ECE2
    Synonyms:KIAA0604
    ORF Names:UNQ403/PRO740
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:13275. ECE2.

    Subcellular locationi

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Topological domaini1 – 178CytoplasmicSequence analysisAdd BLAST178
    Transmembranei179 – 199Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
    Topological domaini200 – 883LumenalSequence analysisAdd BLAST684

    GO - Cellular componenti

    • cytoplasmic vesicle membrane Source: UniProtKB
    • Golgi membrane Source: UniProtKB-SubCell
    • integral component of membrane Source: UniProtKB-KW
    Complete GO annotation...

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    DisGeNETi9718.
    OpenTargetsiENSG00000145194.
    PharmGKBiPA134886910.

    Chemistry databases

    ChEMBLiCHEMBL5890.
    GuidetoPHARMACOLOGYi1616.

    Polymorphism and mutation databases

    BioMutaiECE2.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00000782231 – 883Endothelin-converting enzyme 2Add BLAST883

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Modified residuei39PhosphotyrosineCombined sources1
    Glycosylationi324N-linked (GlcNAc...)Sequence analysis1
    Glycosylationi384N-linked (GlcNAc...)Sequence analysis1
    Glycosylationi429N-linked (GlcNAc...)Sequence analysis1

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    EPDiO60344.
    MaxQBiO60344.
    PaxDbiO60344.
    PeptideAtlasiO60344.
    PRIDEiO60344.

    PTM databases

    iPTMnetiO60344.
    PhosphoSitePlusiO60344.

    Expressioni

    Tissue specificityi

    Expressed in brain. Strongly down-regulated in inferior parietal lobe from Alzheimer disease patients (at protein level).1 Publication

    Gene expression databases

    BgeeiENSG00000145194.
    CleanExiHS_ECE2.
    ExpressionAtlasiO60344. baseline and differential.
    GenevisibleiO60344. HS.

    Organism-specific databases

    HPAiHPA043346.
    HPA062215.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    SYNE4Q8N2053EBI-3906484,EBI-7131783

    Protein-protein interaction databases

    BioGridi115067. 14 interactors.
    IntActiO60344. 5 interactors.
    MINTiMINT-8417701.
    STRINGi9606.ENSP00000384223.

    Chemistry databases

    BindingDBiO60344.

    Structurei

    Secondary structure

    1883
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Helixi19 – 21Combined sources3
    Helixi23 – 29Combined sources7
    Turni30 – 35Combined sources6
    Helixi45 – 52Combined sources8
    Helixi53 – 55Combined sources3
    Beta strandi62 – 65Combined sources4
    Helixi72 – 78Combined sources7
    Beta strandi84 – 89Combined sources6
    Helixi91 – 100Combined sources10
    Turni101 – 103Combined sources3
    Beta strandi108 – 111Combined sources4
    Beta strandi124 – 131Combined sources8
    Helixi132 – 136Combined sources5
    Turni137 – 139Combined sources3
    Helixi148 – 161Combined sources14
    Helixi167 – 169Combined sources3
    Beta strandi170 – 181Combined sources12
    Helixi203 – 209Combined sources7
    Helixi212 – 214Combined sources3
    Beta strandi216 – 221Combined sources6
    Beta strandi229 – 231Combined sources3
    Helixi232 – 234Combined sources3
    Beta strandi236 – 243Combined sources8
    Helixi249 – 255Combined sources7

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    2PXXX-ray1.30A19-255[»]
    ProteinModelPortaliO60344.
    SMRiO60344.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO60344.

    Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Regioni1 – 160Methyltransferase-like regionAdd BLAST160
    Regioni88 – 89S-adenosyl-L-homocysteine binding2
    Regioni113 – 114S-adenosyl-L-homocysteine binding2
    Regioni200 – 883Endothelin-converting enzyme 2 regionAdd BLAST684

    Sequence similaritiesi

    In the N-terminal section; belongs to the methyltransferase superfamily.Curated
    In the C-terminal section; belongs to the peptidase M13 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiKOG2352. Eukaryota.
    KOG3624. Eukaryota.
    COG3590. LUCA.
    GeneTreeiENSGT00760000119162.
    HOVERGENiHBG005554.
    InParanoidiO60344.
    KOiK01415.
    OMAiDHRFESA.
    OrthoDBiEOG091G025Y.
    PhylomeDBiO60344.
    TreeFamiTF315192.

    Family and domain databases

    CDDicd08662. M13. 1 hit.
    Gene3Di3.40.390.10. 2 hits.
    3.40.50.150. 1 hit.
    InterProiIPR029733. ECE2.
    IPR024079. MetalloPept_cat_dom.
    IPR000718. Peptidase_M13.
    IPR018497. Peptidase_M13_C.
    IPR008753. Peptidase_M13_N.
    IPR029063. SAM-dependent_MTases.
    [Graphical view]
    PANTHERiPTHR11733. PTHR11733. 1 hit.
    PTHR11733:SF127. PTHR11733:SF127. 1 hit.
    PfamiPF01431. Peptidase_M13. 1 hit.
    PF05649. Peptidase_M13_N. 1 hit.
    [Graphical view]
    PRINTSiPR00786. NEPRILYSIN.
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

    Isoform A (identifier: O60344-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

            10         20         30         40         50
    MASPGAGRAP PELPERNCGY REVEYWDQRY QGAADSAPYD WFGDFSSFRA
    60 70 80 90 100
    LLEPELRPED RILVLGCGNS ALSYELFLGG FPNVTSVDYS SVVVAAMQAR
    110 120 130 140 150
    HAHVPQLRWE TMDVRKLDFP SASFDVVLEK GTLDALLAGE RDPWTVSSEG
    160 170 180 190 200
    VHTVDQVLSE VGFQKGTRQL LGSRTQLELV LAGASLLLAA LLLGCLVALG
    210 220 230 240 250
    VQYHRDPSHS TCLTEACIRV AGKILESLDR GVSPCEDFYQ FSCGGWIRRN
    260 270 280 290 300
    PLPDGRSRWN TFNSLWDQNQ AILKHLLENT TFNSSSEAEQ KTQRFYLSCL
    310 320 330 340 350
    QVERIEELGA QPLRDLIEKI GGWNITGPWD QDNFMEVLKA VAGTYRATPF
    360 370 380 390 400
    FTVYISADSK SSNSNVIQVD QSGLFLPSRD YYLNRTANEK VLTAYLDYME
    410 420 430 440 450
    ELGMLLGGRP TSTREQMQQV LELEIQLANI TVPQDQRRDE EKIYHKMSIS
    460 470 480 490 500
    ELQALAPSMD WLEFLSFLLS PLELSDSEPV VVYGMDYLQQ VSELINRTEP
    510 520 530 540 550
    SILNNYLIWN LVQKTTSSLD RRFESAQEKL LETLYGTKKS CVPRWQTCIS
    560 570 580 590 600
    NTDDALGFAL GSLFVKATFD RQSKEIAEGM ISEIRTAFEE ALGQLVWMDE
    610 620 630 640 650
    KTRQAAKEKA DAIYDMIGFP DFILEPKELD DVYDGYEISE DSFFQNMLNL
    660 670 680 690 700
    YNFSAKVMAD QLRKPPSRDQ WSMTPQTVNA YYLPTKNEIV FPAGILQAPF
    710 720 730 740 750
    YARNHPKALN FGGIGVVMGH ELTHAFDDQG REYDKEGNLR PWWQNESLAA
    760 770 780 790 800
    FRNHTACMEE QYNQYQVNGE RLNGRQTLGE NIADNGGLKA AYNAYKAWLR
    810 820 830 840 850
    KHGEEQQLPA VGLTNHQLFF VGFAQVWCSV RTPESSHEGL VTDPHSPARF
    860 870 880
    RVLGTLSNSR DFLRHFGCPV GSPMNPGQLC EVW
    Length:883
    Mass (Da):99,773
    Last modified:November 25, 2008 - v4
    Checksum:iEE1C0F4AA4C6B225
    GO
    Isoform B (identifier: O60344-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-159: MASPGAGRAP...GVHTVDQVLS → MNVALQELGA...VEGGASPDAM

    Show »
    Length:765
    Mass (Da):86,470
    Checksum:i89D1B831B5628694
    GO
    Isoform C (identifier: O60344-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-160: MASPGAGRAP...VHTVDQVLSE → MNVALQELGAGSN

    Show »
    Length:736
    Mass (Da):83,322
    Checksum:i77F14FE5AC80E187
    GO
    Isoform D (identifier: O60344-4) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         162-261: GFQKGTRQLL...LPDGRSRWNT → SRVLVPGGRF...HEDFLSAIQL
         262-883: Missing.

    Show »
    Length:255
    Mass (Da):28,306
    Checksum:i39389C81C0798805
    GO
    Isoform 2C (identifier: O60344-5) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-160: MASPGAGRAP...VHTVDQVLSE → MNVALQELGA...SISGLCSRTM

    Show »
    Length:811
    Mass (Da):91,211
    Checksum:i7379F7AFEA937FCE
    GO

    Sequence cautioni

    The sequence AAL30386 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
    The sequence BAA25530 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sequence conflicti467F → S in AAI42951 (PubMed:15489334).Curated1
    Sequence conflicti783A → T in AAQ89362 (PubMed:12975309).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_047752101H → Y.2 PublicationsCorresponds to variant rs7633387dbSNPEnsembl.1
    Natural variantiVAR_037085571R → Q.Corresponds to variant rs35875049dbSNPEnsembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Alternative sequenceiVSP_0391761 – 160MASPG…QVLSE → MNVALQELGAGSNMVEYKRA TLRDEDAPETPVEGGASPDA MEVGKGASPFSPGPSPGMTP GTPRSSGLFWRVTCPHLRSI SGLCSRTM in isoform 2C. 1 PublicationAdd BLAST160
    Alternative sequenceiVSP_0055091 – 160MASPG…QVLSE → MNVALQELGAGSN in isoform C. 3 PublicationsAdd BLAST160
    Alternative sequenceiVSP_0055081 – 159MASPG…DQVLS → MNVALQELGAGSNMVEYKRA TLRDEDAPETPVEGGASPDA M in isoform B. 2 PublicationsAdd BLAST159
    Alternative sequenceiVSP_029333162 – 261GFQKG…SRWNT → SRVLVPGGRFISMTSAAPHF RTRHYAQAYYGWSLRHATYG SGFHFHLYLMHKGGKLSVAQ LALGAQILSPPRPPTSPCFL QDSDHEDFLSAIQL in isoform D. 1 PublicationAdd BLAST100
    Alternative sequenceiVSP_029334262 – 883Missing in isoform D. 1 PublicationAdd BLAST622

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF428263 mRNA. Translation: AAL30386.1. Different initiation.
    AF428264 mRNA. Translation: AAL30387.1.
    AF192531 mRNA. Translation: AAG28399.1.
    AF521189 mRNA. Translation: AAM77664.1.
    AB011176 mRNA. Translation: BAA25530.2. Different initiation.
    AY359003 mRNA. Translation: AAQ89362.1.
    AC061705 Genomic DNA. No translation available.
    AC078797 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW78277.1.
    BC005835 mRNA. Translation: AAH05835.1.
    BC012449 mRNA. Translation: AAH12449.1.
    BC069005 mRNA. Translation: AAH69005.1.
    BC142950 mRNA. Translation: AAI42951.1.
    CCDSiCCDS3255.1. [O60344-4]
    CCDS3256.2. [O60344-1]
    CCDS33899.1. [O60344-3]
    CCDS43179.1. [O60344-5]
    CCDS46969.1. [O60344-2]
    RefSeqiNP_001032401.1. NM_001037324.2. [O60344-3]
    NP_001093590.1. NM_001100120.1. [O60344-5]
    NP_001093591.1. NM_001100121.1. [O60344-2]
    NP_055508.3. NM_014693.3. [O60344-1]
    NP_115707.2. NM_032331.3. [O60344-4]
    UniGeneiHs.146161.

    Genome annotation databases

    EnsembliENST00000324557; ENSP00000314295; ENSG00000145194. [O60344-4]
    ENST00000357474; ENSP00000350066; ENSG00000145194. [O60344-5]
    ENST00000359140; ENSP00000352052; ENSG00000145194. [O60344-3]
    ENST00000402825; ENSP00000384223; ENSG00000145194. [O60344-1]
    ENST00000404464; ENSP00000385846; ENSG00000145194. [O60344-2]
    GeneIDi9718.
    KEGGihsa:9718.
    UCSCiuc003fnh.5. human. [O60344-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF428263 mRNA. Translation: AAL30386.1. Different initiation.
    AF428264 mRNA. Translation: AAL30387.1.
    AF192531 mRNA. Translation: AAG28399.1.
    AF521189 mRNA. Translation: AAM77664.1.
    AB011176 mRNA. Translation: BAA25530.2. Different initiation.
    AY359003 mRNA. Translation: AAQ89362.1.
    AC061705 Genomic DNA. No translation available.
    AC078797 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW78277.1.
    BC005835 mRNA. Translation: AAH05835.1.
    BC012449 mRNA. Translation: AAH12449.1.
    BC069005 mRNA. Translation: AAH69005.1.
    BC142950 mRNA. Translation: AAI42951.1.
    CCDSiCCDS3255.1. [O60344-4]
    CCDS3256.2. [O60344-1]
    CCDS33899.1. [O60344-3]
    CCDS43179.1. [O60344-5]
    CCDS46969.1. [O60344-2]
    RefSeqiNP_001032401.1. NM_001037324.2. [O60344-3]
    NP_001093590.1. NM_001100120.1. [O60344-5]
    NP_001093591.1. NM_001100121.1. [O60344-2]
    NP_055508.3. NM_014693.3. [O60344-1]
    NP_115707.2. NM_032331.3. [O60344-4]
    UniGeneiHs.146161.

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    2PXXX-ray1.30A19-255[»]
    ProteinModelPortaliO60344.
    SMRiO60344.
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi115067. 14 interactors.
    IntActiO60344. 5 interactors.
    MINTiMINT-8417701.
    STRINGi9606.ENSP00000384223.

    Chemistry databases

    BindingDBiO60344.
    ChEMBLiCHEMBL5890.
    GuidetoPHARMACOLOGYi1616.

    Protein family/group databases

    MEROPSiM13.003.

    PTM databases

    iPTMnetiO60344.
    PhosphoSitePlusiO60344.

    Polymorphism and mutation databases

    BioMutaiECE2.

    Proteomic databases

    EPDiO60344.
    MaxQBiO60344.
    PaxDbiO60344.
    PeptideAtlasiO60344.
    PRIDEiO60344.

    Protocols and materials databases

    DNASUi9718.
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000324557; ENSP00000314295; ENSG00000145194. [O60344-4]
    ENST00000357474; ENSP00000350066; ENSG00000145194. [O60344-5]
    ENST00000359140; ENSP00000352052; ENSG00000145194. [O60344-3]
    ENST00000402825; ENSP00000384223; ENSG00000145194. [O60344-1]
    ENST00000404464; ENSP00000385846; ENSG00000145194. [O60344-2]
    GeneIDi9718.
    KEGGihsa:9718.
    UCSCiuc003fnh.5. human. [O60344-1]

    Organism-specific databases

    CTDi9718.
    DisGeNETi9718.
    GeneCardsiECE2.
    H-InvDBHIX0003914.
    HGNCiHGNC:13275. ECE2.
    HPAiHPA043346.
    HPA062215.
    MIMi610145. gene.
    neXtProtiNX_O60344.
    OpenTargetsiENSG00000145194.
    PharmGKBiPA134886910.
    HUGEiSearch...
    GenAtlasiSearch...

    Phylogenomic databases

    eggNOGiKOG2352. Eukaryota.
    KOG3624. Eukaryota.
    COG3590. LUCA.
    GeneTreeiENSGT00760000119162.
    HOVERGENiHBG005554.
    InParanoidiO60344.
    KOiK01415.
    OMAiDHRFESA.
    OrthoDBiEOG091G025Y.
    PhylomeDBiO60344.
    TreeFamiTF315192.

    Enzyme and pathway databases

    BioCyciZFISH:HS07232-MONOMER.
    SABIO-RKO60344.

    Miscellaneous databases

    ChiTaRSiECE2. human.
    EvolutionaryTraceiO60344.
    GenomeRNAii9718.
    PROiO60344.
    SOURCEiSearch...

    Gene expression databases

    BgeeiENSG00000145194.
    CleanExiHS_ECE2.
    ExpressionAtlasiO60344. baseline and differential.
    GenevisibleiO60344. HS.

    Family and domain databases

    CDDicd08662. M13. 1 hit.
    Gene3Di3.40.390.10. 2 hits.
    3.40.50.150. 1 hit.
    InterProiIPR029733. ECE2.
    IPR024079. MetalloPept_cat_dom.
    IPR000718. Peptidase_M13.
    IPR018497. Peptidase_M13_C.
    IPR008753. Peptidase_M13_N.
    IPR029063. SAM-dependent_MTases.
    [Graphical view]
    PANTHERiPTHR11733. PTHR11733. 1 hit.
    PTHR11733:SF127. PTHR11733:SF127. 1 hit.
    PfamiPF01431. Peptidase_M13. 1 hit.
    PF05649. Peptidase_M13_N. 1 hit.
    [Graphical view]
    PRINTSiPR00786. NEPRILYSIN.
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]
    ProtoNetiSearch...

    Entry informationi

    Entry nameiECE2_HUMAN
    AccessioniPrimary (citable) accession number: O60344
    Secondary accession number(s): A5PLK8
    , Q6NTG7, Q6UW36, Q8NFD7, Q96NX3, Q96NX4, Q9BRZ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 25, 2008
    Last modified: November 2, 2016
    This is version 162 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. Peptidase families
      Classification of peptidase families and list of entries
    7. SIMILARITY comments
      Index of protein domains and families

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.