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Protein

TBC1 domain family member 4

Gene

TBC1D4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake.3 Publications

GO - Molecular functioni

GO - Biological processi

  • activation of GTPase activity Source: GO_Central
  • cellular response to insulin stimulus Source: UniProtKB
  • intracellular protein transport Source: GO_Central
  • membrane organization Source: Reactome
  • negative regulation of vesicle fusion Source: Ensembl
  • regulation of vesicle fusion Source: GO_Central
  • vesicle-mediated transport Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000136111-MONOMER.
ReactomeiR-HSA-1445148. Translocation of GLUT4 to the plasma membrane.
SIGNORiO60343.

Names & Taxonomyi

Protein namesi
Recommended name:
TBC1 domain family member 4
Alternative name(s):
Akt substrate of 160 kDa
Short name:
AS160
Gene namesi
Name:TBC1D4
Synonyms:AS160, KIAA0603
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:19165. TBC1D4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

Diabetes mellitus, non-insulin-dependent, 5 (NIDDM5)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
See also OMIM:616087

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi318S → A: 80% reduction of insulin-stimulated GLUT4 translocation; when associated with A-588; A-642 and A-751. 1 Publication1
Mutagenesisi588S → A: 80% reduction of insulin-stimulated GLUT4 translocation; when associated with A-318; A-642 and A-751. 1 Publication1
Mutagenesisi642T → A: 80% reduction of insulin-stimulated GLUT4 translocation; when associated with A-318; A-588 and A-751. 1 Publication1
Mutagenesisi751S → A: 80% reduction of insulin-stimulated GLUT4 translocation; when associated with A-318; A-588 and A-642. 1 Publication1
Mutagenesisi972R → K: Loss of Rab GTPase activation. Only 20% reduction of GLUT4 translocation; even when associated with A-318; A-588; A-642 and A-751. 2 Publications1

Keywords - Diseasei

Diabetes mellitus

Organism-specific databases

DisGeNETi9882.
MalaCardsiTBC1D4.
MIMi616087. phenotype.
OpenTargetsiENSG00000136111.
PharmGKBiPA38807.

Polymorphism and mutation databases

BioMutaiTBC1D4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002080261 – 1298TBC1 domain family member 4Add BLAST1298

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei262PhosphoserineCombined sources1
Modified residuei314PhosphoserineCombined sources1
Modified residuei318Phosphoserine; by PKB/AKT1By similarity1
Modified residuei341PhosphoserineCombined sources1
Modified residuei344PhosphoserineCombined sources1
Modified residuei477N6-acetyllysineCombined sources1
Modified residuei566PhosphoserineCombined sources1
Modified residuei568PhosphothreonineCombined sources1
Modified residuei570PhosphoserineCombined sources1
Modified residuei577Omega-N-methylarginineBy similarity1
Modified residuei588Phosphoserine; by PKB/AKT1Combined sources1 Publication1
Modified residuei591PhosphoserineCombined sources1
Modified residuei609PhosphoserineBy similarity1
Modified residuei613PhosphothreonineBy similarity1
Modified residuei617PhosphoserineBy similarity1
Modified residuei642Phosphothreonine; by PKB/AKT12 Publications1
Modified residuei666PhosphoserineCombined sources1
Modified residuei751Phosphoserine; by PKB/AKT1By similarity1
Modified residuei754PhosphoserineCombined sources1
Modified residuei757PhosphoserineBy similarity1
Modified residuei763PhosphothreonineBy similarity1
Isoform 2 (identifier: O60343-2)
Modified residuei666PhosphoserineCombined sources1
Modified residuei672PhosphoserineCombined sources1
Modified residuei678PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by AKT1; insulin-induced. Also phosphorylated by AMPK in response to insulin. Insulin-stimulated phosphorylation is required for SLC2A4/GLUT4 translocation. Has no effect on SLC2A4/GLUT4 internalization. Physiological hyperinsulinemia increases phosphorylation in skeletal muscle. Insulin-stimulated phosphorylation is reduced by 39% in type 2 diabetic patients.3 Publications

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiO60343.
MaxQBiO60343.
PaxDbiO60343.
PeptideAtlasiO60343.
PRIDEiO60343.

PTM databases

iPTMnetiO60343.
PhosphoSitePlusiO60343.

Miscellaneous databases

PMAP-CutDBO60343.

Expressioni

Tissue specificityi

Widely expressed. Isoform 2 is the highest overexpressed in most tissues. Isoform 1 is highly expressed in skeletal muscle and heart, but was not detectable in the liver nor in adipose tissue. Isoform 2 is strongly expressed in adrenal and thyroid gland, and also in lung, kidney, colon, brain and adipose tissue. Isoform 2 is moderately expressed in skeletal muscle. Expressed in pancreatic Langerhans islets, including beta cells (at protein level). Expression is decreased by twofold in pancreatic islets in type 2 diabetes patients compared to control subjects. Up-regulated in T-cells from patients with atopic dermatitis.3 Publications

Gene expression databases

BgeeiENSG00000136111.
CleanExiHS_TBC1D4.
ExpressionAtlasiO60343. baseline and differential.
GenevisibleiO60343. HS.

Organism-specific databases

HPAiHPA040145.
HPA059885.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115213. 49 interactors.
IntActiO60343. 27 interactors.
MINTiMINT-5005871.
STRINGi9606.ENSP00000366863.

Structurei

Secondary structure

11298
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni874 – 877Combined sources4
Helixi887 – 896Combined sources10
Helixi908 – 917Combined sources10
Turni921 – 923Combined sources3
Helixi924 – 937Combined sources14
Beta strandi943 – 946Combined sources4
Helixi952 – 956Combined sources5
Helixi963 – 970Combined sources8
Helixi978 – 981Combined sources4
Helixi986 – 1001Combined sources16
Turni1002 – 1005Combined sources4
Helixi1011 – 1019Combined sources9
Helixi1024 – 1035Combined sources12
Turni1036 – 1039Combined sources4
Turni1041 – 1044Combined sources4
Helixi1049 – 1063Combined sources15
Helixi1067 – 1075Combined sources9
Helixi1080 – 1083Combined sources4
Helixi1085 – 1090Combined sources6
Turni1091 – 1095Combined sources5
Helixi1098 – 1108Combined sources11
Turni1109 – 1111Combined sources3
Helixi1115 – 1124Combined sources10
Turni1128 – 1133Combined sources6
Helixi1137 – 1144Combined sources8
Turni1145 – 1149Combined sources5
Helixi1153 – 1164Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3QYBX-ray3.50A874-1170[»]
ProteinModelPortaliO60343.
SMRiO60343.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO60343.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 209PID 1PROSITE-ProRule annotationAdd BLAST157
Domaini312 – 468PID 2PROSITE-ProRule annotationAdd BLAST157
Domaini918 – 1112Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST195

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi672 – 759Ser-richAdd BLAST88

Sequence similaritiesi

Contains 2 PID domains.PROSITE-ProRule annotation
Contains 1 Rab-GAP TBC domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4436. Eukaryota.
ENOG410YWJY. LUCA.
GeneTreeiENSGT00750000117238.
HOVERGENiHBG059376.
InParanoidiO60343.
KOiK17902.
OMAiFPHPLEP.
OrthoDBiEOG091G01QW.
PhylomeDBiO60343.
TreeFamiTF317184.

Family and domain databases

Gene3Di2.30.29.30. 3 hits.
InterProiIPR021785. DUF3350.
IPR011993. PH_dom-like.
IPR006020. PTB/PI_dom.
IPR000195. Rab-GTPase-TBC_dom.
IPR033564. TBC1D4.
[Graphical view]
PANTHERiPTHR22957:SF195. PTHR22957:SF195. 1 hit.
PfamiPF11830. DUF3350. 1 hit.
PF00640. PID. 2 hits.
PF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00462. PTB. 2 hits.
SM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
SSF50729. SSF50729. 3 hits.
PROSITEiPS01179. PID. 1 hit.
PS50086. TBC_RABGAP. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O60343-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPPSCIQDE PFPHPLEPEP GVSAQPGPGK PSDKRFRLWY VGGSCLDHRT
60 70 80 90 100
TLPMLPWLMA EIRRRSQKPE AGGCGAPAAR EVILVLSAPF LRCVPAPGAG
110 120 130 140 150
ASGGTSPSAT QPNPAVFIFE HKAQHISRFI HNSHDLTYFA YLIKAQPDDP
160 170 180 190 200
ESQMACHVFR ATDPSQVPDV ISSIRQLSKA AMKEDAKPSK DNEDAFYNSQ
210 220 230 240 250
KFEVLYCGKV TVTHKKAPSS LIDDCMEKFS LHEQQRLKIQ GEQRGPDPGE
260 270 280 290 300
DLADLEVVVP GSPGDCLPEE ADGTDTHLGL PAGASQPALT SSRVCFPERI
310 320 330 340 350
LEDSGFDEQQ EFRSRCSSVT GVQRRVHEGS QKSQPRRRHA SAPSHVQPSD
360 370 380 390 400
SEKNRTMLFQ VGRFEINLIS PDTKSVVLEK NFKDISSCSQ GIKHVDHFGF
410 420 430 440 450
ICRESPEPGL SQYICYVFQC ASESLVDEVM LTLKQAFSTA AALQSAKTQI
460 470 480 490 500
KLCEACPMHS LHKLCERIEG LYPPRAKLVI QRHLSSLTDN EQADIFERVQ
510 520 530 540 550
KMKPVSDQEE NELVILHLRQ LCEAKQKTHV HIGEGPSTIS NSTIPENATS
560 570 580 590 600
SGRFKLDILK NKAKRSLTSS LENIFSRGAN RMRGRLGSVD SFERSNSLAS
610 620 630 640 650
EKDYSPGDSP PGTPPASPPS SAWQTFPEED SDSPQFRRRA HTFSHPPSST
660 670 680 690 700
KRKLNLQDGR AQGVRSPLLR QSSSEQCSNL SSVRRMYKES NSSSSLPSLH
710 720 730 740 750
TSFSAPSFTA PSFLKSFYQN SGRLSPQYEN EIRQDTASES SDGEGRKRTS
760 770 780 790 800
STCSNESLSV GGTSVTPRRI SWRQRIFLRV ASPMNKSPSA MQQQDGLDRN
810 820 830 840 850
ELLPLSPLSP TMEEEPLVVF LSGEDDPEKI EERKKSKELR SLWRKAIHQQ
860 870 880 890 900
ILLLRMEKEN QKLEASRDEL QSRKVKLDYE EVGACQKEVL ITWDKKLLNC
910 920 930 940 950
RAKIRCDMED IHTLLKEGVP KSRRGEIWQF LALQYRLRHR LPNKQQPPDI
960 970 980 990 1000
SYKELLKQLT AQQHAILVDL GRTFPTHPYF SVQLGPGQLS LFNLLKAYSL
1010 1020 1030 1040 1050
LDKEVGYCQG ISFVAGVLLL HMSEEQAFEM LKFLMYDLGF RKQYRPDMMS
1060 1070 1080 1090 1100
LQIQMYQLSR LLHDYHRDLY NHLEENEISP SLYAAPWFLT LFASQFSLGF
1110 1120 1130 1140 1150
VARVFDIIFL QGTEVIFKVA LSLLSSQETL IMECESFENI VEFLKNTLPD
1160 1170 1180 1190 1200
MNTSEMEKII TQVFEMDISK QLHAYEVEYH VLQDELQESS YSCEDSETLE
1210 1220 1230 1240 1250
KLERANSQLK RQNMDLLEKL QVAHTKIQAL ESNLENLLTR ETKMKSLIRT
1260 1270 1280 1290
LEQEKMAYQK TVEQLRKLLP ADALVNCDLL LRDLNCNPNN KAKIGNKP
Length:1,298
Mass (Da):146,563
Last modified:June 7, 2005 - v2
Checksum:i8DC70CE887C0B311
GO
Isoform 2 (identifier: O60343-2) [UniParc]FASTAAdd to basket
Also known as: AS160_tv2

The sequence of this isoform differs from the canonical sequence as follows:
     678-740: Missing.

Show »
Length:1,235
Mass (Da):139,556
Checksum:i2A688BE2C17FD422
GO
Isoform 3 (identifier: O60343-3) [UniParc]FASTAAdd to basket
Also known as: AS160_tv3

The sequence of this isoform differs from the canonical sequence as follows:
     733-740: Missing.

Show »
Length:1,290
Mass (Da):145,689
Checksum:i38A0D7A205A0D252
GO
Isoform 4 (identifier: O60343-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-783: Missing.
     865-917: Missing.

Note: No experimental confirmation available.
Show »
Length:462
Mass (Da):53,850
Checksum:iB063DE6885C060DA
GO
Isoform 5 (identifier: O60343-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-783: Missing.

Note: No experimental confirmation available.
Show »
Length:515
Mass (Da):60,095
Checksum:i18CDA70728CE1CBB
GO

Sequence cautioni

The sequence BAA25529 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti644S → G in CAH18416 (PubMed:17974005).Curated1
Sequence conflicti845K → E in CAH18416 (PubMed:17974005).Curated1
Sequence conflicti864E → EG in BAH16628 (PubMed:19077034).Curated1
Sequence conflicti864E → EG in BAA25529 (PubMed:9628581).Curated1
Sequence conflicti864E → EG in AAI51240 (PubMed:15489334).Curated1
Sequence conflicti867R → G in CAH18416 (PubMed:17974005).Curated1
Sequence conflicti1137F → L in CAH18416 (PubMed:17974005).Curated1
Sequence conflicti1178E → G in BAG62187 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061891619P → L.Corresponds to variant rs56223054dbSNPEnsembl.1
Natural variantiVAR_059855819V → I.Combined sources4 PublicationsCorresponds to variant rs1062087dbSNPEnsembl.1
Natural variantiVAR_0618921119V → A.Corresponds to variant rs58232698dbSNPEnsembl.1
Natural variantiVAR_0525341147T → M.Corresponds to variant rs9600455dbSNPEnsembl.1
Natural variantiVAR_0525351275V → A.3 PublicationsCorresponds to variant rs557337dbSNPEnsembl.1
Natural variantiVAR_0548621284L → I.Corresponds to variant rs11616741dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0368681 – 783Missing in isoform 4 and isoform 5. 1 PublicationAdd BLAST783
Alternative sequenceiVSP_036869678 – 740Missing in isoform 2. 1 PublicationAdd BLAST63
Alternative sequenceiVSP_036870733 – 740Missing in isoform 3. 2 Publications8
Alternative sequenceiVSP_036871865 – 917Missing in isoform 4. 1 PublicationAdd BLAST53

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM207106 mRNA. Translation: CAR62509.1.
FM207107 mRNA. Translation: CAR62510.1.
AB449885 mRNA. Translation: BAH16628.1.
AB011175 mRNA. Translation: BAA25529.2. Different initiation.
AK300468 mRNA. Translation: BAG62187.1.
AK304091 mRNA. Translation: BAG64997.1.
AL139230, AL162571 Genomic DNA. Translation: CAH70991.1.
AL162571, AL139230 Genomic DNA. Translation: CAI39591.1.
BC151239 mRNA. Translation: AAI51240.1.
CR749622 mRNA. Translation: CAH18416.1.
CCDSiCCDS41901.1. [O60343-1]
CCDS66563.1. [O60343-2]
CCDS66564.1. [O60343-3]
PIRiT00261.
RefSeqiNP_001273587.1. NM_001286658.2. [O60343-3]
NP_001273588.1. NM_001286659.2. [O60343-2]
NP_055647.2. NM_014832.4. [O60343-1]
UniGeneiHs.210891.

Genome annotation databases

EnsembliENST00000377625; ENSP00000366852; ENSG00000136111. [O60343-2]
ENST00000377636; ENSP00000366863; ENSG00000136111. [O60343-1]
ENST00000431480; ENSP00000395986; ENSG00000136111. [O60343-3]
GeneIDi9882.
KEGGihsa:9882.
UCSCiuc001vjl.3. human. [O60343-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM207106 mRNA. Translation: CAR62509.1.
FM207107 mRNA. Translation: CAR62510.1.
AB449885 mRNA. Translation: BAH16628.1.
AB011175 mRNA. Translation: BAA25529.2. Different initiation.
AK300468 mRNA. Translation: BAG62187.1.
AK304091 mRNA. Translation: BAG64997.1.
AL139230, AL162571 Genomic DNA. Translation: CAH70991.1.
AL162571, AL139230 Genomic DNA. Translation: CAI39591.1.
BC151239 mRNA. Translation: AAI51240.1.
CR749622 mRNA. Translation: CAH18416.1.
CCDSiCCDS41901.1. [O60343-1]
CCDS66563.1. [O60343-2]
CCDS66564.1. [O60343-3]
PIRiT00261.
RefSeqiNP_001273587.1. NM_001286658.2. [O60343-3]
NP_001273588.1. NM_001286659.2. [O60343-2]
NP_055647.2. NM_014832.4. [O60343-1]
UniGeneiHs.210891.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3QYBX-ray3.50A874-1170[»]
ProteinModelPortaliO60343.
SMRiO60343.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115213. 49 interactors.
IntActiO60343. 27 interactors.
MINTiMINT-5005871.
STRINGi9606.ENSP00000366863.

PTM databases

iPTMnetiO60343.
PhosphoSitePlusiO60343.

Polymorphism and mutation databases

BioMutaiTBC1D4.

Proteomic databases

EPDiO60343.
MaxQBiO60343.
PaxDbiO60343.
PeptideAtlasiO60343.
PRIDEiO60343.

Protocols and materials databases

DNASUi9882.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377625; ENSP00000366852; ENSG00000136111. [O60343-2]
ENST00000377636; ENSP00000366863; ENSG00000136111. [O60343-1]
ENST00000431480; ENSP00000395986; ENSG00000136111. [O60343-3]
GeneIDi9882.
KEGGihsa:9882.
UCSCiuc001vjl.3. human. [O60343-1]

Organism-specific databases

CTDi9882.
DisGeNETi9882.
GeneCardsiTBC1D4.
H-InvDBHIX0017963.
HGNCiHGNC:19165. TBC1D4.
HPAiHPA040145.
HPA059885.
MalaCardsiTBC1D4.
MIMi612465. gene.
616087. phenotype.
neXtProtiNX_O60343.
OpenTargetsiENSG00000136111.
PharmGKBiPA38807.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4436. Eukaryota.
ENOG410YWJY. LUCA.
GeneTreeiENSGT00750000117238.
HOVERGENiHBG059376.
InParanoidiO60343.
KOiK17902.
OMAiFPHPLEP.
OrthoDBiEOG091G01QW.
PhylomeDBiO60343.
TreeFamiTF317184.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000136111-MONOMER.
ReactomeiR-HSA-1445148. Translocation of GLUT4 to the plasma membrane.
SIGNORiO60343.

Miscellaneous databases

ChiTaRSiTBC1D4. human.
EvolutionaryTraceiO60343.
GeneWikiiTBC1D4.
GenomeRNAii9882.
PMAP-CutDBO60343.
PROiO60343.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136111.
CleanExiHS_TBC1D4.
ExpressionAtlasiO60343. baseline and differential.
GenevisibleiO60343. HS.

Family and domain databases

Gene3Di2.30.29.30. 3 hits.
InterProiIPR021785. DUF3350.
IPR011993. PH_dom-like.
IPR006020. PTB/PI_dom.
IPR000195. Rab-GTPase-TBC_dom.
IPR033564. TBC1D4.
[Graphical view]
PANTHERiPTHR22957:SF195. PTHR22957:SF195. 1 hit.
PfamiPF11830. DUF3350. 1 hit.
PF00640. PID. 2 hits.
PF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00462. PTB. 2 hits.
SM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
SSF50729. SSF50729. 3 hits.
PROSITEiPS01179. PID. 1 hit.
PS50086. TBC_RABGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTBCD4_HUMAN
AccessioniPrimary (citable) accession number: O60343
Secondary accession number(s): A7E2X8
, B4DU25, B4E235, B6ETN8, B6ETN9, Q5W0B9, Q68D14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: June 7, 2005
Last modified: November 2, 2016
This is version 150 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.