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O60336 (MABP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitogen-activated protein kinase-binding protein 1
Alternative name(s):
JNK-binding protein 1
Short name=JNKBP-1
Gene names
Name:MAPKBP1
Synonyms:JNKBP1, KIAA0596
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1514 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in JNK signaling pathway By similarity.

Subunit structure

Interacts with MAPK10 By similarity.

Sequence similarities

Contains 12 WD repeats.

Sequence caution

The sequence BAA25522.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
WD repeat
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O60336-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O60336-2)

The sequence of this isoform differs from the canonical sequence as follows:
     274-279: Missing.
     1134-1410: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: O60336-3)

The sequence of this isoform differs from the canonical sequence as follows:
     274-396: Missing.
     1411-1412: Missing.
Isoform 4 (identifier: O60336-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-499: Missing.
Note: No experimental confirmation available.
Isoform 5 (identifier: O60336-5)

The sequence of this isoform differs from the canonical sequence as follows:
     214-215: NA → RC
     216-1514: Missing.
Note: No experimental confirmation available.
Isoform 6 (identifier: O60336-6)

The sequence of this isoform differs from the canonical sequence as follows:
     274-279: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.9
Chain2 – 15141513Mitogen-activated protein kinase-binding protein 1
PRO_0000334158

Regions

Repeat88 – 12942WD 1
Repeat132 – 17342WD 2
Repeat175 – 21339WD 3
Repeat276 – 31540WD 4
Repeat342 – 38140WD 5
Repeat387 – 43650WD 6
Repeat477 – 51640WD 7
Repeat519 – 56143WD 8
Repeat565 – 60642WD 9
Repeat614 – 65340WD 10
Repeat659 – 69840WD 11
Repeat701 – 74040WD 12
Compositional bias1041 – 10477Poly-Glu
Compositional bias1114 – 11196Poly-Ser
Compositional bias1387 – 13904Poly-Pro

Amino acid modifications

Modified residue21N-acetylalanine Ref.9

Natural variations

Alternative sequence1 – 499499Missing in isoform 4.
VSP_033629
Alternative sequence214 – 2152NA → RC in isoform 5.
VSP_033630
Alternative sequence216 – 15141299Missing in isoform 5.
VSP_033631
Alternative sequence274 – 396123Missing in isoform 3.
VSP_033632
Alternative sequence274 – 2796Missing in isoform 2 and isoform 6.
VSP_033633
Alternative sequence1134 – 1410277Missing in isoform 2.
VSP_033634
Alternative sequence1411 – 14122Missing in isoform 3.
VSP_033635
Natural variant2041Y → S.
Corresponds to variant rs4354909 [ dbSNP | Ensembl ].
VAR_043343
Natural variant3131L → V.
Corresponds to variant rs1201689 [ dbSNP | Ensembl ].
VAR_043344
Natural variant12401R → P. Ref.1 Ref.2 Ref.5 Ref.8
Corresponds to variant rs3959569 [ dbSNP | Ensembl ].
VAR_043345

Experimental info

Sequence conflict8431P → S in AAH36660. Ref.8
Sequence conflict14441K → R in AL833267. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 25, 2008. Version 4.
Checksum: 13FD125E44CABBFD

FASTA1,514163,818
        10         20         30         40         50         60 
MAVEGSTITS RIKNLLRSPS IKLRRSKAGN RREDLSSKVT LEKVLGITVS GGRGLACDPR 

        70         80         90        100        110        120 
SGLVAYPAGC VVVLFNPRKH KQHHILNSSR KTITALAFSP DGKYLVTGES GHMPAVRVWD 

       130        140        150        160        170        180 
VAEHSQVAEL QEHKYGVACV AFSPSAKYIV SVGYQHDMIV NVWAWKKNIV VASNKVSSRV 

       190        200        210        220        230        240 
TAVSFSEDCS YFVTAGNRHI KFWYLDDSKT SKVNATVPLL GRSGLLGELR NNLFTDVACG 

       250        260        270        280        290        300 
RGKKADSTFC ITSSGLLCEF SDRRLLDKWV ELRNIDSFTT TVAHCISVSQ DYIFCGCADG 

       310        320        330        340        350        360 
TVRLFNPSNL HFLSTLPRPH ALGTDIASVT EASRLFSGVA NARYPDTIAL TFDPTNQWLS 

       370        380        390        400        410        420 
CVYNDHSIYV WDVRDPKKVG KVYSALYHSS CVWSVEVYPE VKDSNQACLP PSSFITCSSD 

       430        440        450        460        470        480 
NTIRLWNTES SGVHGSTLHR NILSSDLIKI IYVDGNTQAL LDTELPGGDK ADASLLDPRV 

       490        500        510        520        530        540 
GIRSVCVSPN GQHLASGDRM GTLRVHELQS LSEMLKVEAH DSEILCLEYS KPDTGLKLLA 

       550        560        570        580        590        600 
SASRDRLIHV LDAGREYSLQ QTLDEHSSSI TAVKFAASDG QVRMISCGAD KSIYFRTAQK 

       610        620        630        640        650        660 
SGDGVQFTRT HHVVRKTTLY DMDVEPSWKY TAIGCQDRNI RIFNISSGKQ KKLFKGSQGE 

       670        680        690        700        710        720 
DGTLIKVQTD PSGIYIATSC SDKNLSIFDF SSGECVATMF GHSEIVTGMK FSNDCKHLIS 

       730        740        750        760        770        780 
VSGDSCIFVW RLSSEMTISM RQRLAELRQR QRGGKQQGPS SPQRASGPNR HQAPSMLSPG 

       790        800        810        820        830        840 
PALSSDSDKE GEDEGTEEEL PALPVLAKST KKALASVPSP ALPRSLSHWE MSRAQESVGF 

       850        860        870        880        890        900 
LDPAPAANPG PRRRGRWVQP GVELSVRSML DLRQLETLAP SLQDPSQDSL AIIPSGPRKH 

       910        920        930        940        950        960 
GQEALETSLT SQNEKPPRPQ ASQPCSYPHI IRLLSQEEGV FAQDLEPAPI EDGIVYPEPS 

       970        980        990       1000       1010       1020 
DNPTMDTSEF QVQAPARGTL GRVYPGSRSS EKHSPDSACS VDYSSSCLSS PEHPTEDSES 

      1030       1040       1050       1060       1070       1080 
TEPLSVDGIS SDLEEPAEGD EEEEEEEGGM GPYGLQEGSP QTPDQEQFLK QHFETLASGA 

      1090       1100       1110       1120       1130       1140 
APGAPVQVPE RSESRSISSR FLLQVQTRPL REPSPSSSSL ALMSRPAQVP QASGEQPRGN 

      1150       1160       1170       1180       1190       1200 
GANPPGAPPE VEPSSGNPSP QQAASVLLPR CRLNPDSSWA PKRVATASPF SGLQKAQSVH 

      1210       1220       1230       1240       1250       1260 
SLVPQERHEA SLQAPSPGAL LSREIEAQDG LGSLPPADGR PSRPHSYQNP TTSSMAKISR 

      1270       1280       1290       1300       1310       1320 
SISVGENLGL VAEPQAHAPI RVSPLSKLAL PSRAHLVLDI PKPLPDRPTL AAFSPVTKGR 

      1330       1340       1350       1360       1370       1380 
APGEAEKPGF PVGLGKAHST TERWACLGEG TTPKPRTECQ AHPGPSSPCA QQLPVSSLFQ 

      1390       1400       1410       1420       1430       1440 
GPENLQPPPP EKTPNPMECT KPGAALSQDS EPAVSLEQCE QLVAELRGSV RQAVRLYHSV 

      1450       1460       1470       1480       1490       1500 
AGCKMPSAEQ SRIAQLLRDT FSSVRQELEA VAGAVLSSPG SSPGAVGAEQ TQALLEQYSE 

      1510 
LLLRAVERRM ERKL 

« Hide

Isoform 2 [UniParc].

Checksum: 562B680D20C616B0
Show »

FASTA1,231134,309
Isoform 3 [UniParc].

Checksum: 3AD9E18431DA7614
Show »

FASTA1,389149,945
Isoform 4 [UniParc].

Checksum: 2E47B6DD20087E6E
Show »

FASTA1,015109,155
Isoform 5 [UniParc].

Checksum: 5FFAA575381E3C07
Show »

FASTA21523,707
Isoform 6 [UniParc].

Checksum: 332C0E0E9ABD2B91
Show »

FASTA1,508163,141

References

« Hide 'large scale' references
[1]"Alternative splice variants encoding unstable protein domains exist in the human brain."
Homma K., Kikuno R.F., Nagase T., Ohara O., Nishikawa K.
J. Mol. Biol. 343:1207-1220(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), VARIANT PRO-1240.
Tissue: Brain.
[2]"Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT PRO-1240.
Tissue: Brain.
[3]"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
Tissue: Testis.
[5]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6), VARIANT PRO-1240.
Tissue: Skeletal muscle.
[6]"Analysis of the DNA sequence and duplication history of human chromosome 15."
Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. expand/collapse author list , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4), VARIANT PRO-1240.
Tissue: Testis.
[9]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB177850 mRNA. Translation: BAD66828.1.
AB011168 mRNA. Translation: BAA25522.2. Different initiation.
AK292414 mRNA. Translation: BAF85103.1.
AL833267 mRNA. No translation available.
AC020659 Genomic DNA. No translation available.
AC073657 Genomic DNA. No translation available.
CH471125 Genomic DNA. Translation: EAW92516.1.
BC036660 mRNA. Translation: AAH36660.1.
BC113983 mRNA. Translation: AAI13984.1.
BC114493 mRNA. Translation: AAI14494.1.
PIRT00270.
RefSeqNP_001122080.1. NM_001128608.1.
NP_001252540.1. NM_001265611.1.
NP_055809.2. NM_014994.2.
UniGeneHs.513661.

3D structure databases

ProteinModelPortalO60336.
SMRO60336. Positions 84-208, 371-748.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116650. 1 interaction.
IntActO60336. 1 interaction.
MINTMINT-2870106.
STRING9606.ENSP00000374581.

PTM databases

PhosphoSiteO60336.

Proteomic databases

PaxDbO60336.
PRIDEO60336.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000456763; ENSP00000393099; ENSG00000137802. [O60336-1]
ENST00000457542; ENSP00000397570; ENSG00000137802. [O60336-6]
ENST00000514566; ENSP00000426154; ENSG00000137802. [O60336-2]
GeneID23005.
KEGGhsa:23005.
UCSCuc001zoj.4. human. [O60336-6]
uc001zok.4. human. [O60336-1]
uc010bci.3. human. [O60336-2]
uc010bck.3. human. [O60336-4]
uc010bcl.3. human. [O60336-3]

Organism-specific databases

CTD23005.
GeneCardsGC15P042067.
H-InvDBHIX0022002.
HGNCHGNC:29536. MAPKBP1.
HPAHPA030832.
neXtProtNX_O60336.
PharmGKBPA142671479.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2319.
HOVERGENHBG108669.
InParanoidO60336.
OMAPEHPNED.
OrthoDBEOG74N5FW.
PhylomeDBO60336.
TreeFamTF323254.

Enzyme and pathway databases

SignaLinkO60336.

Gene expression databases

ArrayExpressO60336.
BgeeO60336.
CleanExHS_MAPKBP1.
GenevestigatorO60336.

Family and domain databases

Gene3D2.130.10.10. 5 hits.
InterProIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamPF00400. WD40. 9 hits.
[Graphical view]
SMARTSM00320. WD40. 12 hits.
[Graphical view]
SUPFAMSSF50978. SSF50978. 4 hits.
PROSITEPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSMAPKBP1. human.
GenomeRNAi23005.
NextBio43917.
PROO60336.

Entry information

Entry nameMABP1_HUMAN
AccessionPrimary (citable) accession number: O60336
Secondary accession number(s): A6NM93 expand/collapse secondary AC list , A8K8P9, Q14CB5, Q14CD8, Q49AJ8, Q5W9G9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 25, 2008
Last modified: April 16, 2014
This is version 107 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM