O60336 (MABP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mitogen-activated protein kinase-binding protein 1

Alternative name(s):
JNK-binding protein 1
Short name=JNKBP-1

Gene names

Name:	MAPKBP1
Synonyms:	JNKBP1, KIAA0596

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1514 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in JNK signaling pathway By similarity.
Subunit structure	Interacts with MAPK10 By similarity.
Sequence similarities	Contains 12 WD repeats.
Sequence caution	The sequence BAA25522.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat WD repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O60336-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O60336-2)

The sequence of this isoform differs from the canonical sequence as follows:
     274-279: Missing.
     1134-1410: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: O60336-3)

The sequence of this isoform differs from the canonical sequence as follows:
     274-396: Missing.
     1411-1412: Missing.

Isoform 4 (identifier: O60336-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-499: Missing.

Note: No experimental confirmation available.

Isoform 5 (identifier: O60336-5)

The sequence of this isoform differs from the canonical sequence as follows:
     214-215: NA → RC
     216-1514: Missing.

Note: No experimental confirmation available.

Isoform 6 (identifier: O60336-6)

The sequence of this isoform differs from the canonical sequence as follows:
     274-279: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1514	1514	Mitogen-activated protein kinase-binding protein 1		PRO_0000334158
Regions
	Repeat	88 – 129	42	WD 1
	Repeat	132 – 173	42	WD 2
	Repeat	175 – 213	39	WD 3
	Repeat	276 – 315	40	WD 4
	Repeat	342 – 381	40	WD 5
	Repeat	387 – 436	50	WD 6
	Repeat	477 – 516	40	WD 7
	Repeat	519 – 561	43	WD 8
	Repeat	565 – 606	42	WD 9
	Repeat	614 – 653	40	WD 10
	Repeat	659 – 698	40	WD 11
	Repeat	701 – 740	40	WD 12
	Compositional bias	1041 – 1047	7	Poly-Glu
	Compositional bias	1114 – 1119	6	Poly-Ser
	Compositional bias	1387 – 1390	4	Poly-Pro
Natural variations
	Alternative sequence	1 – 499	499	Missing in isoform 4.		VSP_033629
	Alternative sequence	214 – 215	2	NA → RC in isoform 5.		VSP_033630
	Alternative sequence	216 – 1514	1299	Missing in isoform 5.		VSP_033631
	Alternative sequence	274 – 396	123	Missing in isoform 3.		VSP_033632
	Alternative sequence	274 – 279	6	Missing in isoform 2 and isoform 6.		VSP_033633
	Alternative sequence	1134 – 1410	277	Missing in isoform 2.		VSP_033634
	Alternative sequence	1411 – 1412	2	Missing in isoform 3.		VSP_033635
	Natural variant	204	1	Y → S. Corresponds to variant rs4354909 [ dbSNP | Ensembl ].		VAR_043343
	Natural variant	313	1	L → V. Corresponds to variant rs1201689 [ dbSNP | Ensembl ].		VAR_043344
	Natural variant	1240	1	R → P. Ref.1 Ref.2 Ref.5 Ref.8 Corresponds to variant rs3959569 [ dbSNP | Ensembl ].		VAR_043345
Experimental info
	Sequence conflict	843	1	P → S in AAH36660. Ref.8
	Sequence conflict	1444	1	K → R in AL833267. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 25, 2008. Version 4. Checksum: 13FD125E44CABBFD	FASTA	1,514	163,818
	10 20 30 40 50 60 MAVEGSTITS RIKNLLRSPS IKLRRSKAGN RREDLSSKVT LEKVLGITVS GGRGLACDPR 70 80 90 100 110 120 SGLVAYPAGC VVVLFNPRKH KQHHILNSSR KTITALAFSP DGKYLVTGES GHMPAVRVWD 130 140 150 160 170 180 VAEHSQVAEL QEHKYGVACV AFSPSAKYIV SVGYQHDMIV NVWAWKKNIV VASNKVSSRV 190 200 210 220 230 240 TAVSFSEDCS YFVTAGNRHI KFWYLDDSKT SKVNATVPLL GRSGLLGELR NNLFTDVACG 250 260 270 280 290 300 RGKKADSTFC ITSSGLLCEF SDRRLLDKWV ELRNIDSFTT TVAHCISVSQ DYIFCGCADG 310 320 330 340 350 360 TVRLFNPSNL HFLSTLPRPH ALGTDIASVT EASRLFSGVA NARYPDTIAL TFDPTNQWLS 370 380 390 400 410 420 CVYNDHSIYV WDVRDPKKVG KVYSALYHSS CVWSVEVYPE VKDSNQACLP PSSFITCSSD 430 440 450 460 470 480 NTIRLWNTES SGVHGSTLHR NILSSDLIKI IYVDGNTQAL LDTELPGGDK ADASLLDPRV 490 500 510 520 530 540 GIRSVCVSPN GQHLASGDRM GTLRVHELQS LSEMLKVEAH DSEILCLEYS KPDTGLKLLA 550 560 570 580 590 600 SASRDRLIHV LDAGREYSLQ QTLDEHSSSI TAVKFAASDG QVRMISCGAD KSIYFRTAQK 610 620 630 640 650 660 SGDGVQFTRT HHVVRKTTLY DMDVEPSWKY TAIGCQDRNI RIFNISSGKQ KKLFKGSQGE 670 680 690 700 710 720 DGTLIKVQTD PSGIYIATSC SDKNLSIFDF SSGECVATMF GHSEIVTGMK FSNDCKHLIS 730 740 750 760 770 780 VSGDSCIFVW RLSSEMTISM RQRLAELRQR QRGGKQQGPS SPQRASGPNR HQAPSMLSPG 790 800 810 820 830 840 PALSSDSDKE GEDEGTEEEL PALPVLAKST KKALASVPSP ALPRSLSHWE MSRAQESVGF 850 860 870 880 890 900 LDPAPAANPG PRRRGRWVQP GVELSVRSML DLRQLETLAP SLQDPSQDSL AIIPSGPRKH 910 920 930 940 950 960 GQEALETSLT SQNEKPPRPQ ASQPCSYPHI IRLLSQEEGV FAQDLEPAPI EDGIVYPEPS 970 980 990 1000 1010 1020 DNPTMDTSEF QVQAPARGTL GRVYPGSRSS EKHSPDSACS VDYSSSCLSS PEHPTEDSES 1030 1040 1050 1060 1070 1080 TEPLSVDGIS SDLEEPAEGD EEEEEEEGGM GPYGLQEGSP QTPDQEQFLK QHFETLASGA 1090 1100 1110 1120 1130 1140 APGAPVQVPE RSESRSISSR FLLQVQTRPL REPSPSSSSL ALMSRPAQVP QASGEQPRGN 1150 1160 1170 1180 1190 1200 GANPPGAPPE VEPSSGNPSP QQAASVLLPR CRLNPDSSWA PKRVATASPF SGLQKAQSVH 1210 1220 1230 1240 1250 1260 SLVPQERHEA SLQAPSPGAL LSREIEAQDG LGSLPPADGR PSRPHSYQNP TTSSMAKISR 1270 1280 1290 1300 1310 1320 SISVGENLGL VAEPQAHAPI RVSPLSKLAL PSRAHLVLDI PKPLPDRPTL AAFSPVTKGR 1330 1340 1350 1360 1370 1380 APGEAEKPGF PVGLGKAHST TERWACLGEG TTPKPRTECQ AHPGPSSPCA QQLPVSSLFQ 1390 1400 1410 1420 1430 1440 GPENLQPPPP EKTPNPMECT KPGAALSQDS EPAVSLEQCE QLVAELRGSV RQAVRLYHSV 1450 1460 1470 1480 1490 1500 AGCKMPSAEQ SRIAQLLRDT FSSVRQELEA VAGAVLSSPG SSPGAVGAEQ TQALLEQYSE 1510 LLLRAVERRM ERKL
	Isoform 2 [UniParc]. Checksum: 562B680D20C616B0	FASTA	1,231	134,309
	10 20 30 40 50 60 MAVEGSTITS RIKNLLRSPS IKLRRSKAGN RREDLSSKVT LEKVLGITVS GGRGLACDPR 70 80 90 100 110 120 SGLVAYPAGC VVVLFNPRKH KQHHILNSSR KTITALAFSP DGKYLVTGES GHMPAVRVWD 130 140 150 160 170 180 VAEHSQVAEL QEHKYGVACV AFSPSAKYIV SVGYQHDMIV NVWAWKKNIV VASNKVSSRV 190 200 210 220 230 240 TAVSFSEDCS YFVTAGNRHI KFWYLDDSKT SKVNATVPLL GRSGLLGELR NNLFTDVACG 250 260 270 280 290 300 RGKKADSTFC ITSSGLLCEF SDRRLLDKWV ELRTTVAHCI SVSQDYIFCG CADGTVRLFN 310 320 330 340 350 360 PSNLHFLSTL PRPHALGTDI ASVTEASRLF SGVANARYPD TIALTFDPTN QWLSCVYNDH 370 380 390 400 410 420 SIYVWDVRDP KKVGKVYSAL YHSSCVWSVE VYPEVKDSNQ ACLPPSSFIT CSSDNTIRLW 430 440 450 460 470 480 NTESSGVHGS TLHRNILSSD LIKIIYVDGN TQALLDTELP GGDKADASLL DPRVGIRSVC 490 500 510 520 530 540 VSPNGQHLAS GDRMGTLRVH ELQSLSEMLK VEAHDSEILC LEYSKPDTGL KLLASASRDR 550 560 570 580 590 600 LIHVLDAGRE YSLQQTLDEH SSSITAVKFA ASDGQVRMIS CGADKSIYFR TAQKSGDGVQ 610 620 630 640 650 660 FTRTHHVVRK TTLYDMDVEP SWKYTAIGCQ DRNIRIFNIS SGKQKKLFKG SQGEDGTLIK 670 680 690 700 710 720 VQTDPSGIYI ATSCSDKNLS IFDFSSGECV ATMFGHSEIV TGMKFSNDCK HLISVSGDSC 730 740 750 760 770 780 IFVWRLSSEM TISMRQRLAE LRQRQRGGKQ QGPSSPQRAS GPNRHQAPSM LSPGPALSSD 790 800 810 820 830 840 SDKEGEDEGT EEELPALPVL AKSTKKALAS VPSPALPRSL SHWEMSRAQE SVGFLDPAPA 850 860 870 880 890 900 ANPGPRRRGR WVQPGVELSV RSMLDLRQLE TLAPSLQDPS QDSLAIIPSG PRKHGQEALE 910 920 930 940 950 960 TSLTSQNEKP PRPQASQPCS YPHIIRLLSQ EEGVFAQDLE PAPIEDGIVY PEPSDNPTMD 970 980 990 1000 1010 1020 TSEFQVQAPA RGTLGRVYPG SRSSEKHSPD SACSVDYSSS CLSSPEHPTE DSESTEPLSV 1030 1040 1050 1060 1070 1080 DGISSDLEEP AEGDEEEEEE EGGMGPYGLQ EGSPQTPDQE QFLKQHFETL ASGAAPGAPV 1090 1100 1110 1120 1130 1140 QVPERSESRS ISSRFLLQVQ TRPLREPSPS SSSLALMSRP AQVPQASEPA VSLEQCEQLV 1150 1160 1170 1180 1190 1200 AELRGSVRQA VRLYHSVAGC KMPSAEQSRI AQLLRDTFSS VRQELEAVAG AVLSSPGSSP 1210 1220 1230 GAVGAEQTQA LLEQYSELLL RAVERRMERK L
	Isoform 3 [UniParc]. Checksum: 3AD9E18431DA7614	FASTA	1,389	149,945
	10 20 30 40 50 60 MAVEGSTITS RIKNLLRSPS IKLRRSKAGN RREDLSSKVT LEKVLGITVS GGRGLACDPR 70 80 90 100 110 120 SGLVAYPAGC VVVLFNPRKH KQHHILNSSR KTITALAFSP DGKYLVTGES GHMPAVRVWD 130 140 150 160 170 180 VAEHSQVAEL QEHKYGVACV AFSPSAKYIV SVGYQHDMIV NVWAWKKNIV VASNKVSSRV 190 200 210 220 230 240 TAVSFSEDCS YFVTAGNRHI KFWYLDDSKT SKVNATVPLL GRSGLLGELR NNLFTDVACG 250 260 270 280 290 300 RGKKADSTFC ITSSGLLCEF SDRRLLDKWV ELRVYPEVKD SNQACLPPSS FITCSSDNTI 310 320 330 340 350 360 RLWNTESSGV HGSTLHRNIL SSDLIKIIYV DGNTQALLDT ELPGGDKADA SLLDPRVGIR 370 380 390 400 410 420 SVCVSPNGQH LASGDRMGTL RVHELQSLSE MLKVEAHDSE ILCLEYSKPD TGLKLLASAS 430 440 450 460 470 480 RDRLIHVLDA GREYSLQQTL DEHSSSITAV KFAASDGQVR MISCGADKSI YFRTAQKSGD 490 500 510 520 530 540 GVQFTRTHHV VRKTTLYDMD VEPSWKYTAI GCQDRNIRIF NISSGKQKKL FKGSQGEDGT 550 560 570 580 590 600 LIKVQTDPSG IYIATSCSDK NLSIFDFSSG ECVATMFGHS EIVTGMKFSN DCKHLISVSG 610 620 630 640 650 660 DSCIFVWRLS SEMTISMRQR LAELRQRQRG GKQQGPSSPQ RASGPNRHQA PSMLSPGPAL 670 680 690 700 710 720 SSDSDKEGED EGTEEELPAL PVLAKSTKKA LASVPSPALP RSLSHWEMSR AQESVGFLDP 730 740 750 760 770 780 APAANPGPRR RGRWVQPGVE LSVRSMLDLR QLETLAPSLQ DPSQDSLAII PSGPRKHGQE 790 800 810 820 830 840 ALETSLTSQN EKPPRPQASQ PCSYPHIIRL LSQEEGVFAQ DLEPAPIEDG IVYPEPSDNP 850 860 870 880 890 900 TMDTSEFQVQ APARGTLGRV YPGSRSSEKH SPDSACSVDY SSSCLSSPEH PTEDSESTEP 910 920 930 940 950 960 LSVDGISSDL EEPAEGDEEE EEEEGGMGPY GLQEGSPQTP DQEQFLKQHF ETLASGAAPG 970 980 990 1000 1010 1020 APVQVPERSE SRSISSRFLL QVQTRPLREP SPSSSSLALM SRPAQVPQAS GEQPRGNGAN 1030 1040 1050 1060 1070 1080 PPGAPPEVEP SSGNPSPQQA ASVLLPRCRL NPDSSWAPKR VATASPFSGL QKAQSVHSLV 1090 1100 1110 1120 1130 1140 PQERHEASLQ APSPGALLSR EIEAQDGLGS LPPADGRPSR PHSYQNPTTS SMAKISRSIS 1150 1160 1170 1180 1190 1200 VGENLGLVAE PQAHAPIRVS PLSKLALPSR AHLVLDIPKP LPDRPTLAAF SPVTKGRAPG 1210 1220 1230 1240 1250 1260 EAEKPGFPVG LGKAHSTTER WACLGEGTTP KPRTECQAHP GPSSPCAQQL PVSSLFQGPE 1270 1280 1290 1300 1310 1320 NLQPPPPEKT PNPMECTKPG AALSQDSAVS LEQCEQLVAE LRGSVRQAVR LYHSVAGCKM 1330 1340 1350 1360 1370 1380 PSAEQSRIAQ LLRDTFSSVR QELEAVAGAV LSSPGSSPGA VGAEQTQALL EQYSELLLRA VERRMERKL
	Isoform 4 [UniParc]. Checksum: 2E47B6DD20087E6E	FASTA	1,015	109,155
	10 20 30 40 50 60 MGTLRVHELQ SLSEMLKVEA HDSEILCLEY SKPDTGLKLL ASASRDRLIH VLDAGREYSL 70 80 90 100 110 120 QQTLDEHSSS ITAVKFAASD GQVRMISCGA DKSIYFRTAQ KSGDGVQFTR THHVVRKTTL 130 140 150 160 170 180 YDMDVEPSWK YTAIGCQDRN IRIFNISSGK QKKLFKGSQG EDGTLIKVQT DPSGIYIATS 190 200 210 220 230 240 CSDKNLSIFD FSSGECVATM FGHSEIVTGM KFSNDCKHLI SVSGDSCIFV WRLSSEMTIS 250 260 270 280 290 300 MRQRLAELRQ RQRGGKQQGP SSPQRASGPN RHQAPSMLSP GPALSSDSDK EGEDEGTEEE 310 320 330 340 350 360 LPALPVLAKS TKKALASVPS PALPRSLSHW EMSRAQESVG FLDPAPAANP GPRRRGRWVQ 370 380 390 400 410 420 PGVELSVRSM LDLRQLETLA PSLQDPSQDS LAIIPSGPRK HGQEALETSL TSQNEKPPRP 430 440 450 460 470 480 QASQPCSYPH IIRLLSQEEG VFAQDLEPAP IEDGIVYPEP SDNPTMDTSE FQVQAPARGT 490 500 510 520 530 540 LGRVYPGSRS SEKHSPDSAC SVDYSSSCLS SPEHPTEDSE STEPLSVDGI SSDLEEPAEG 550 560 570 580 590 600 DEEEEEEEGG MGPYGLQEGS PQTPDQEQFL KQHFETLASG AAPGAPVQVP ERSESRSISS 610 620 630 640 650 660 RFLLQVQTRP LREPSPSSSS LALMSRPAQV PQASGEQPRG NGANPPGAPP EVEPSSGNPS 670 680 690 700 710 720 PQQAASVLLP RCRLNPDSSW APKRVATASP FSGLQKAQSV HSLVPQERHE ASLQAPSPGA 730 740 750 760 770 780 LLSREIEAQD GLGSLPPADG RPSRPHSYQN PTTSSMAKIS RSISVGENLG LVAEPQAHAP 790 800 810 820 830 840 IRVSPLSKLA LPSRAHLVLD IPKPLPDRPT LAAFSPVTKG RAPGEAEKPG FPVGLGKAHS 850 860 870 880 890 900 TTERWACLGE GTTPKPRTEC QAHPGPSSPC AQQLPVSSLF QGPENLQPPP PEKTPNPMEC 910 920 930 940 950 960 TKPGAALSQD SEPAVSLEQC EQLVAELRGS VRQAVRLYHS VAGCKMPSAE QSRIAQLLRD 970 980 990 1000 1010 TFSSVRQELE AVAGAVLSSP GSSPGAVGAE QTQALLEQYS ELLLRAVERR MERKL
	Isoform 5 [UniParc]. Checksum: 5FFAA575381E3C07	FASTA	215	23,707
	10 20 30 40 50 60 MAVEGSTITS RIKNLLRSPS IKLRRSKAGN RREDLSSKVT LEKVLGITVS GGRGLACDPR 70 80 90 100 110 120 SGLVAYPAGC VVVLFNPRKH KQHHILNSSR KTITALAFSP DGKYLVTGES GHMPAVRVWD 130 140 150 160 170 180 VAEHSQVAEL QEHKYGVACV AFSPSAKYIV SVGYQHDMIV NVWAWKKNIV VASNKVSSRV 190 200 210 TAVSFSEDCS YFVTAGNRHI KFWYLDDSKT SKVRC
	Isoform 6 [UniParc]. Checksum: 332C0E0E9ABD2B91	FASTA	1,508	163,141
	10 20 30 40 50 60 MAVEGSTITS RIKNLLRSPS IKLRRSKAGN RREDLSSKVT LEKVLGITVS GGRGLACDPR 70 80 90 100 110 120 SGLVAYPAGC VVVLFNPRKH KQHHILNSSR KTITALAFSP DGKYLVTGES GHMPAVRVWD 130 140 150 160 170 180 VAEHSQVAEL QEHKYGVACV AFSPSAKYIV SVGYQHDMIV NVWAWKKNIV VASNKVSSRV 190 200 210 220 230 240 TAVSFSEDCS YFVTAGNRHI KFWYLDDSKT SKVNATVPLL GRSGLLGELR NNLFTDVACG 250 260 270 280 290 300 RGKKADSTFC ITSSGLLCEF SDRRLLDKWV ELRTTVAHCI SVSQDYIFCG CADGTVRLFN 310 320 330 340 350 360 PSNLHFLSTL PRPHALGTDI ASVTEASRLF SGVANARYPD TIALTFDPTN QWLSCVYNDH 370 380 390 400 410 420 SIYVWDVRDP KKVGKVYSAL YHSSCVWSVE VYPEVKDSNQ ACLPPSSFIT CSSDNTIRLW 430 440 450 460 470 480 NTESSGVHGS TLHRNILSSD LIKIIYVDGN TQALLDTELP GGDKADASLL DPRVGIRSVC 490 500 510 520 530 540 VSPNGQHLAS GDRMGTLRVH ELQSLSEMLK VEAHDSEILC LEYSKPDTGL KLLASASRDR 550 560 570 580 590 600 LIHVLDAGRE YSLQQTLDEH SSSITAVKFA ASDGQVRMIS CGADKSIYFR TAQKSGDGVQ 610 620 630 640 650 660 FTRTHHVVRK TTLYDMDVEP SWKYTAIGCQ DRNIRIFNIS SGKQKKLFKG SQGEDGTLIK 670 680 690 700 710 720 VQTDPSGIYI ATSCSDKNLS IFDFSSGECV ATMFGHSEIV TGMKFSNDCK HLISVSGDSC 730 740 750 760 770 780 IFVWRLSSEM TISMRQRLAE LRQRQRGGKQ QGPSSPQRAS GPNRHQAPSM LSPGPALSSD 790 800 810 820 830 840 SDKEGEDEGT EEELPALPVL AKSTKKALAS VPSPALPRSL SHWEMSRAQE SVGFLDPAPA 850 860 870 880 890 900 ANPGPRRRGR WVQPGVELSV RSMLDLRQLE TLAPSLQDPS QDSLAIIPSG PRKHGQEALE 910 920 930 940 950 960 TSLTSQNEKP PRPQASQPCS YPHIIRLLSQ EEGVFAQDLE PAPIEDGIVY PEPSDNPTMD 970 980 990 1000 1010 1020 TSEFQVQAPA RGTLGRVYPG SRSSEKHSPD SACSVDYSSS CLSSPEHPTE DSESTEPLSV 1030 1040 1050 1060 1070 1080 DGISSDLEEP AEGDEEEEEE EGGMGPYGLQ EGSPQTPDQE QFLKQHFETL ASGAAPGAPV 1090 1100 1110 1120 1130 1140 QVPERSESRS ISSRFLLQVQ TRPLREPSPS SSSLALMSRP AQVPQASGEQ PRGNGANPPG 1150 1160 1170 1180 1190 1200 APPEVEPSSG NPSPQQAASV LLPRCRLNPD SSWAPKRVAT ASPFSGLQKA QSVHSLVPQE 1210 1220 1230 1240 1250 1260 RHEASLQAPS PGALLSREIE AQDGLGSLPP ADGRPSRPHS YQNPTTSSMA KISRSISVGE 1270 1280 1290 1300 1310 1320 NLGLVAEPQA HAPIRVSPLS KLALPSRAHL VLDIPKPLPD RPTLAAFSPV TKGRAPGEAE 1330 1340 1350 1360 1370 1380 KPGFPVGLGK AHSTTERWAC LGEGTTPKPR TECQAHPGPS SPCAQQLPVS SLFQGPENLQ 1390 1400 1410 1420 1430 1440 PPPPEKTPNP MECTKPGAAL SQDSEPAVSL EQCEQLVAEL RGSVRQAVRL YHSVAGCKMP 1450 1460 1470 1480 1490 1500 SAEQSRIAQL LRDTFSSVRQ ELEAVAGAVL SSPGSSPGAV GAEQTQALLE QYSELLLRAV ERRMERKL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Alternative splice variants encoding unstable protein domains exist in the human brain." Homma K., Kikuno R.F., Nagase T., Ohara O., Nishikawa K. J. Mol. Biol. 343:1207-1220(2004) [PubMed: 15491607] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), VARIANT PRO-1240. Tissue: Brain.
[2]	"Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:31-39(1998) [PubMed: 9628581] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT PRO-1240. Tissue: Brain.
[3]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed: 12168954] [Abstract] Cited for: SEQUENCE REVISION.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5). Tissue: Testis.
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6), VARIANT PRO-1240. Tissue: Skeletal muscle.
[6]	"Analysis of the DNA sequence and duplication history of human chromosome 15." Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C. Nature 440:671-675(2006) [PubMed: 16572171] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4), VARIANT PRO-1240. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB177850 mRNA. Translation: BAD66828.1. AB011168 mRNA. Translation: BAA25522.2. Different initiation. AK292414 mRNA. Translation: BAF85103.1. AL833267 mRNA. No translation available. AC020659 Genomic DNA. No translation available. AC073657 Genomic DNA. No translation available. CH471125 Genomic DNA. Translation: EAW92516.1. BC036660 mRNA. Translation: AAH36660.1. BC113983 mRNA. Translation: AAI13984.1. BC114493 mRNA. Translation: AAI14494.1.
IPI	IPI00167154. IPI00479587. IPI00782945. IPI00783044. IPI00943806. IPI00963846.
PIR	T00270.
RefSeq	NP_001122080.1. NM_001128608.1. NP_055809.2. NM_014994.2.
UniGene	Hs.513661.
3D structure databases
ProteinModelPortal	O60336.
SMR	O60336. Positions 39-208, 349-374, 387-430, 473-734.
ModBase	Search...
Protein-protein interaction databases
IntAct	O60336. 1 interaction.
MINT	MINT-2870106.
STRING	O60336.
PTM databases
PhosphoSite	O60336.
Proteomic databases
PRIDE	O60336.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000389931; ENSP00000374581; ENSG00000137802. ENST00000456763; ENSP00000393099; ENSG00000137802.
GeneID	23005.
KEGG	hsa:23005.
UCSC	uc001zok.2. human. uc010bci.1. human. uc010bcj.1. human.
Organism-specific databases
CTD	23005.
GeneCards	GC15P042067.
H-InvDB	HIX0022002.
HGNC	HGNC:29536. MAPKBP1.
HPA	HPA030832.
neXtProt	NX_O60336.
PharmGKB	PA142671479.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG14910.
GeneTree	ENSGT00530000063072.
HOVERGEN	HBG108669.
InParanoid	O60336.
OMA	GNRREDL.
PhylomeDB	O60336.
Gene expression databases
ArrayExpress	O60336.
Bgee	O60336.
CleanEx	HS_MAPKBP1.
Genevestigator	O60336.
Family and domain databases
InterPro	IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR011046. WD40_repeat-like_dom. IPR017986. WD40_repeat_dom. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 5 hits.
Pfam	PF00400. WD40. 10 hits. [Graphical view]
SMART	SM00320. WD40. 12 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 2 hits.
PROSITE	PS00678. WD_REPEATS_1. False negative. PS50082. WD_REPEATS_2. 1 hit. PS50294. WD_REPEATS_REGION. 3 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MABP1_HUMAN

Accession

Primary (citable) accession number: O60336
Secondary accession number(s): A6NM93 , A8K8P9, Q14CB5, Q14CD8, Q49AJ8, Q5W9G9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	November 25, 2008
Last modified:	January 25, 2012
This is version 87 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.