Kinesin-like protein KIF1B - Homo sapiens (Human)

Names and origin

Protein names

Recommended name:
Kinesin-like protein KIF1B
Short name=Klp

Gene names

Name:	KIF1B
Synonyms:	KIAA0591, KIAA1448

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	1816 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Motor for anterograde transport of mitochondria. Has a microtubule plus end-directed motility.
Subunit structure	Interacts with KBP.
Subcellular location	Cytoplasmic vesicleBy similarity. Cytoplasm › cytoskeletonBy similarity. Mitochondrion.
Tissue specificity	Isoform 3 is abundant in the skeletal muscle. It is also expressed in fetal brain, lung and kidney, and adult heart, placenta, testis, ovary and small intestine. Isoform 2 is abundant in the brain and also expressed in fetal heart, lung, liver and kidney, and adult skeletal muscle, placenta, liver, kidney, heart, spleen, thymus, prostate, testis, ovary, small intestine, colon and pancreas.
Involvement in disease	Defects in KIF1B are the cause of Charcot-Marie-Tooth disease type 2A1 (CMT2A1) [MIM:118210]. CMT2A1 is a form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy or CMT1, and primary peripheral axonal neuropathy or CMT2. Neuropathies of the CMT2 group are characterized by signs of axonal regeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy.
Sequence similarities	Belongs to the kinesin-like protein family. Unc-104 subfamily. Contains 1 FHA domain. Contains 1 kinesin-motor domain. Contains 1 PH domain.

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Ontologies

Keywords
Cellular component	Cytoplasm Cytoplasmic vesicle Cytoskeleton Microtubule Mitochondrion
Coding sequence diversity	Alternative splicing
Disease	Charcot-Marie-Tooth disease Disease mutation
Domain	Coiled coil
Ligand	ATP-binding Nucleotide-binding
Molecular function	Motor protein
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	anterograde axon cargo transport Inferred from sequence or structural similarity. Source: UniProtKB nerve-nerve synaptic transmission Inferred from sequence or structural similarity. Source: UniProtKB neuromuscular synaptic transmission Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	cytoplasmic vesicle membrane Inferred from sequence or structural similarity. Source: UniProtKB microtubule Inferred from electronic annotation. Source: UniProtKB-KW microtubule associated complex Inferred from sequence or structural similarity. Source: UniProtKB mitochondrion Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro ATPase activity Inferred from sequence or structural similarity. Source: UniProtKB kinesin binding Traceable author statement. Source: UniProtKB microtubule motor activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

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Binary interactions

With	Entry	#Exp.	IntAct
DLG1	Q12959	1	EBI-465669,EBI-357481
DLG4	P78352	1	EBI-465669,EBI-80389
MAGI1	Q96QZ7	1	EBI-465669,EBI-924464

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Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O60333-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O60333-2) Also known as: Beta; The sequence of this isoform differs from the canonical sequence as follows: 289-294: Missing. 394-434: IDPLIDDYSGSGSKYLKDFQNNKHRYLLASENQRPGHFSTA → T

Isoform 3 (identifier: O60333-3) Also known as: Alpha; The sequence of this isoform differs from the canonical sequence as follows: 289-294: Missing. 394-434: IDPLIDDYSGSGSKYLKDFQNNKHRYLLASENQRPGHFSTA → T 707-1196: YESKLQALQK...KPIVFEVFGH → ADSDSGDDSD...NLKAGRETTV 1197-1816: Missing.

Isoform 4 (identifier: O60333-4) The sequence of this isoform differs from the canonical sequence as follows: 1804-1816: SKLSRRCPSQSKY → PGHLASEIIREDKSVSFSCQ

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1816

1816

Kinesin-like protein KIF1B

PRO_0000125407

Regions

Domain

1 – 361

361

Kinesin-motor

Domain

556 – 612

57

FHA

Domain

1702 – 1799

98

PH

Nucleotide binding

97 – 104

8

ATP By similarity

Region

270 – 350

81

Interaction with KBP

Coiled coil

365 – 386

22

Potential

Coiled coil

470 – 502

33

Potential

Coiled coil

668 – 737

70

Potential

Coiled coil

841 – 869

29

Potential

Amino acid modifications

Modified residue

1057

1

Phosphoserine

Modified residue

1454

1

Phosphoserine

Modified residue

1487

1

Phosphoserine

Natural variations

Alternative sequence

289 – 294

6

Missing in isoform 2 and isoform 3.

VSP_002858

Alternative sequence

394 – 434

41

IDPLI…HFSTA → T in isoform 2 and isoform 3.

VSP_002859

Alternative sequence

707 – 1196

490

YESKL…EVFGH → ADSDSGDDSDKRSCEESWKL ITSLREKLPPSKLQTIVKKC GLPSSGKKREPIKMYQIPQR RRLSKDSKWVTISDLKIQAV KEICYEVALNDFRHSRQEIE ALAIVKMKELCAMYGKKDPN ERDSWRAVARDVWDTVGVGD EKIEDVMATGKGSTDVDDLK VHIDKLEDILQEVKKQNNMK DEEIKVLRNKMLKMEKVLPL IGSQEQKSPGSHKAKEPVGA GVSSTSENNVSKGDNGELAK EERVSQLMNGDPAFRRGRLR WMRQEQIRFKNLQQQEITKQ LRRQNVPHRFIPPENRKPRF PFKSNPKHRNSWSPGTHIII TEDEVIELRIPKDDEARKGN KEESQEKGGKGAFKDPQFPW GSQGMRSQDHIQVSKQHINN QQQPPQLRWRSNSLNNGQPK STRCQASASAESLNSHSGHP TADVQTFQAKRHIHQHRQSY CNYNTGGQLEGNAATSYQKQ TDKPSHCSQFVTPPRMRRQF SAPNLKAGRETTV in isoform 3.

VSP_002860

Alternative sequence

1197 – 1816

620

Missing in isoform 3.

VSP_002861

Alternative sequence

1804 – 1816

13

SKLSR…SQSKY → PGHLASEIIREDKSVSFSCQ in isoform 4.

VSP_009381

Natural variant

98

1

Q → L in CMT2A1.

VAR_011515

Experimental info

Sequence conflict

87

1

E → G in BAA25517. Ref.7

Sequence conflict

129 – 131

3

KIN → TNH in AAK49332. Ref.3

Sequence conflict

129 – 131

3

KIN → TNH in AAK85155. Ref.4

Sequence conflict

129 – 131

3

KIN → TNH in AAN17742. Ref.5

Sequence conflict

170

1

E → D in AAK49332. Ref.3

Sequence conflict

170

1

E → D in AAK85155. Ref.4

Sequence conflict

170

1

E → D in AAN17742. Ref.5

Sequence conflict

174

1

L → R in AAK49332. Ref.3

Sequence conflict

174

1

L → R in AAK85155. Ref.4

Sequence conflict

174

1

L → R in AAN17742. Ref.5

Sequence conflict

219 – 221

3

AVF → VVY in AAK49332. Ref.3

Sequence conflict

219 – 221

3

AVF → VVY in AAK85155. Ref.4

Sequence conflict

219 – 221

3

AVF → VVY in AAN17742. Ref.5

Sequence conflict

235 – 239

5

NLSTE → ILATV in AAK49332. Ref.3

Sequence conflict

235 – 239

5

NLSTE → ILATV in AAK85155. Ref.4

Sequence conflict

235 – 239

5

NLSTE → ILATV in AAN17742. Ref.5

Sequence conflict

244

1

I → T in AAK49332. Ref.3

Sequence conflict

244

1

I → T in AAK85155. Ref.4

Sequence conflict

244

1

I → T in AAN17742. Ref.5

Sequence conflict

253

1

E → D in AAK49332. Ref.3

Sequence conflict

253

1

E → D in AAK85155. Ref.4

Sequence conflict

253

1

E → D in AAN17742. Ref.5

Sequence conflict

256

1

D → A in AAK49332. Ref.3

Sequence conflict

256

1

D → A in AAK85155. Ref.4

Sequence conflict

256

1

D → A in AAN17742. Ref.5

Sequence conflict

270

1

N → I in AAK49332. Ref.3

Sequence conflict

270

1

N → I in AAK85155. Ref.4

Sequence conflict

270

1

N → I in AAN17742. Ref.5

Sequence conflict

363

1

D → G in BAB69038. Ref.2

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Sequences

Sequence		Length	Mass (Da)
Isoform 1 [UniParc]. Last modified October 17, 2006. Version 5. Checksum: AD62F0515978C783 Show »	FASTA	1,816	204,476
10 20 30 40 50 60 MSGASVKVAV RVRPFNSRET SKESKCIIQM QGNSTSIINP KNPKEAPKSF SFDYSYWSHT 70 80 90 100 110 120 SPEDPCFASQ NRVYNDIGKE MLLHAFEGYN VCIFAYGQTG AGKSYTMMGK QEESQAGIIP 130 140 150 160 170 180 QLCEELFEKI NDNCNEEMSY SVEVSYMEIY CERVRDLLNP KNKGNLRVRE HPLLGPYVED 190 200 210 220 230 240 LSKLAVTSYT DIADLMDAGN KARTVAATNM NETSSRSHAV FTIVFTQKKH DNETNLSTEK 250 260 270 280 290 300 VSKISLVDLA GSERADSTGA KGTRLKEGAN INKSLTTLGK VISALAEVDN CTSKSKKKKK 310 320 330 340 350 360 TDFIPYRDSV LTWLLRENLG GNSRTAMVAA LSPADINYDE TLSTLRYADR AKQIKCNAVI 370 380 390 400 410 420 NEDPNAKLVR ELKEEVTRLK DLLRAQGLGD IIDIDPLIDD YSGSGSKYLK DFQNNKHRYL 430 440 450 460 470 480 LASENQRPGH FSTASMGSLT SSPSSCSLSS QVGLTSVTSI QERIMSTPGG EEAIERLKES 490 500 510 520 530 540 EKIIAELNET WEEKLRKTEA IRMEREALLA EMGVAIREDG GTLGVFSPKK TPHLVNLNED 550 560 570 580 590 600 PLMSECLLYY IKDGITRVGQ ADAERRQDIV LSGAHIKEEH CIFRSERSNS GEVIVTLEPC 610 620 630 640 650 660 ERSETYVNGK RVSQPVQLRS GNRIIMGKNH VFRFNHPEQA RAEREKTPSA ETPSEPVDWT 670 680 690 700 710 720 FAQRELLEKQ GIDMKQEMEK RLQEMEILYK KEKEEADLLL EQQRLDYESK LQALQKQVET 730 740 750 760 770 780 RSLAAETTEE EEEEEEVPWT QHEFELAQWA FRKWKSHQFT SLRDLLWGNA VYLKEANAIS 790 800 810 820 830 840 VELKKKVQFQ FVLLTDTLYS PLPPELLPTE MEKTHEDRPF PRTVVAVEVQ DLKNGATHYW 850 860 870 880 890 900 SLEKLKQRLD LMREMYDRAG EMASSAQDES ETTVTGSDPF YDRFHWFKLV GSSPIFHGCV 910 920 930 940 950 960 NERLADRTPS PTFSTADSDI TELADEQQDE MEDFDDEAFV DDAGSDAGTE EGSDLFSDGH 970 980 990 1000 1010 1020 DPFYDRSPWF ILVGRAFVYL SNLLYPVPLI HRVAIVSEKG EVRGFLRVAV QAIAADEEAP 1030 1040 1050 1060 1070 1080 DYGSGIRQSG TAKISFDNEY FNQSDFSSVA MTRSGLSLEE LRIVEGQGQS SEVITPPEEI 1090 1100 1110 1120 1130 1140 SRINDLDLKS STLLDGKMVM EGFSEEIGNH LKLGSAFTFR VTVLQASGIL PEYADIFCQF 1150 1160 1170 1180 1190 1200 NFLHRHDEAF STEPLKNNGR GSPLAFYHVQ NIAVEITESF VDYIKTKPIV FEVFGHYQQH 1210 1220 1230 1240 1250 1260 PLHLQGQELN SPPQPCRRFF PPPMPLSKPV PATKLNTMSK TSLGQSMSKY DLLVWFEISE 1270 1280 1290 1300 1310 1320 LEPTGEYIPA VVDHTAGLPC QGTFLLHQGI QRRITVTIIH EKGSELHWKD VRELVVGRIR 1330 1340 1350 1360 1370 1380 NKPEVDEAAV DAILSLNIIS AKYLKSSHNS SRTFYRFEAV WDSSLHNSLL LNRVTPYGEK 1390 1400 1410 1420 1430 1440 IYMTLSAYLE LDHCIQPAVI TKDVCMVFYS RDAKISPPRS LRSLFGSGYS KSPDSNRVTG 1450 1460 1470 1480 1490 1500 IYELSLCKMS DTGSPGMQRR RRKILDTSVA YVRGEENLAG WRPRGDSLIL EHQWELEKLE 1510 1520 1530 1540 1550 1560 LLHEVEKTRH FLLLRERLGD SIPKSLSDSL SPSLSSGTLS TSTSISSQIS TTTFESAITP 1570 1580 1590 1600 1610 1620 SESSGYDSGD IESLVDREKE LATKCLQLLT HTFNREFSQV HGSVSDCKLS DISPIGRDPS 1630 1640 1650 1660 1670 1680 ESSFSSATLT PSSTCPSLVD SRSNSLDQKT PEANSRASSP CPEFEQFQIV PAVETPYLAR 1690 1700 1710 1720 1730 1740 AGKNEFLNLV PDIEEIRPSS VVSKKGYLHF KEPLYSNWAK HFVVVRRPYV FIYNSDKDPV 1750 1760 1770 1780 1790 1800 ERGIINLSTA QVEYSEDQQA MVKTPNTFAV CTKHRGVLLQ ALNDKDMNDW LYAFNPLLAG 1810 TIRSKLSRRC PSQSKY « Hide
Isoform 2 (Beta) [UniParc]. Checksum: 8AE6BB2665AF702C Show »		1,770	199,263
10 20 30 40 50 60 MSGASVKVAV RVRPFNSRET SKESKCIIQM QGNSTSIINP KNPKEAPKSF SFDYSYWSHT 70 80 90 100 110 120 SPEDPCFASQ NRVYNDIGKE MLLHAFEGYN VCIFAYGQTG AGKSYTMMGK QEESQAGIIP 130 140 150 160 170 180 QLCEELFEKI NDNCNEEMSY SVEVSYMEIY CERVRDLLNP KNKGNLRVRE HPLLGPYVED 190 200 210 220 230 240 LSKLAVTSYT DIADLMDAGN KARTVAATNM NETSSRSHAV FTIVFTQKKH DNETNLSTEK 250 260 270 280 290 300 VSKISLVDLA GSERADSTGA KGTRLKEGAN INKSLTTLGK VISALAEVSK KKKKTDFIPY 310 320 330 340 350 360 RDSVLTWLLR ENLGGNSRTA MVAALSPADI NYDETLSTLR YADRAKQIKC NAVINEDPNA 370 380 390 400 410 420 KLVRELKEEV TRLKDLLRAQ GLGDIIDTSM GSLTSSPSSC SLSSQVGLTS VTSIQERIMS 430 440 450 460 470 480 TPGGEEAIER LKESEKIIAE LNETWEEKLR KTEAIRMERE ALLAEMGVAI REDGGTLGVF 490 500 510 520 530 540 SPKKTPHLVN LNEDPLMSEC LLYYIKDGIT RVGQADAERR QDIVLSGAHI KEEHCIFRSE 550 560 570 580 590 600 RSNSGEVIVT LEPCERSETY VNGKRVSQPV QLRSGNRIIM GKNHVFRFNH PEQARAEREK 610 620 630 640 650 660 TPSAETPSEP VDWTFAQREL LEKQGIDMKQ EMEKRLQEME ILYKKEKEEA DLLLEQQRLD 670 680 690 700 710 720 YESKLQALQK QVETRSLAAE TTEEEEEEEE VPWTQHEFEL AQWAFRKWKS HQFTSLRDLL 730 740 750 760 770 780 WGNAVYLKEA NAISVELKKK VQFQFVLLTD TLYSPLPPEL LPTEMEKTHE DRPFPRTVVA 790 800 810 820 830 840 VEVQDLKNGA THYWSLEKLK QRLDLMREMY DRAGEMASSA QDESETTVTG SDPFYDRFHW 850 860 870 880 890 900 FKLVGSSPIF HGCVNERLAD RTPSPTFSTA DSDITELADE QQDEMEDFDD EAFVDDAGSD 910 920 930 940 950 960 AGTEEGSDLF SDGHDPFYDR SPWFILVGRA FVYLSNLLYP VPLIHRVAIV SEKGEVRGFL 970 980 990 1000 1010 1020 RVAVQAIAAD EEAPDYGSGI RQSGTAKISF DNEYFNQSDF SSVAMTRSGL SLEELRIVEG 1030 1040 1050 1060 1070 1080 QGQSSEVITP PEEISRINDL DLKSSTLLDG KMVMEGFSEE IGNHLKLGSA FTFRVTVLQA 1090 1100 1110 1120 1130 1140 SGILPEYADI FCQFNFLHRH DEAFSTEPLK NNGRGSPLAF YHVQNIAVEI TESFVDYIKT 1150 1160 1170 1180 1190 1200 KPIVFEVFGH YQQHPLHLQG QELNSPPQPC RRFFPPPMPL SKPVPATKLN TMSKTSLGQS 1210 1220 1230 1240 1250 1260 MSKYDLLVWF EISELEPTGE YIPAVVDHTA GLPCQGTFLL HQGIQRRITV TIIHEKGSEL 1270 1280 1290 1300 1310 1320 HWKDVRELVV GRIRNKPEVD EAAVDAILSL NIISAKYLKS SHNSSRTFYR FEAVWDSSLH 1330 1340 1350 1360 1370 1380 NSLLLNRVTP YGEKIYMTLS AYLELDHCIQ PAVITKDVCM VFYSRDAKIS PPRSLRSLFG 1390 1400 1410 1420 1430 1440 SGYSKSPDSN RVTGIYELSL CKMSDTGSPG MQRRRRKILD TSVAYVRGEE NLAGWRPRGD 1450 1460 1470 1480 1490 1500 SLILEHQWEL EKLELLHEVE KTRHFLLLRE RLGDSIPKSL SDSLSPSLSS GTLSTSTSIS 1510 1520 1530 1540 1550 1560 SQISTTTFES AITPSESSGY DSGDIESLVD REKELATKCL QLLTHTFNRE FSQVHGSVSD 1570 1580 1590 1600 1610 1620 CKLSDISPIG RDPSESSFSS ATLTPSSTCP SLVDSRSNSL DQKTPEANSR ASSPCPEFEQ 1630 1640 1650 1660 1670 1680 FQIVPAVETP YLARAGKNEF LNLVPDIEEI RPSSVVSKKG YLHFKEPLYS NWAKHFVVVR 1690 1700 1710 1720 1730 1740 RPYVFIYNSD KDPVERGIIN LSTAQVEYSE DQQAMVKTPN TFAVCTKHRG VLLQALNDKD 1750 1760 1770 MNDWLYAFNP LLAGTIRSKL SRRCPSQSKY « Hide
Isoform 3 (Alpha) [UniParc]. Checksum: 6F0D8846CD283811 Show »		1,153	130,363
10 20 30 40 50 60 MSGASVKVAV RVRPFNSRET SKESKCIIQM QGNSTSIINP KNPKEAPKSF SFDYSYWSHT 70 80 90 100 110 120 SPEDPCFASQ NRVYNDIGKE MLLHAFEGYN VCIFAYGQTG AGKSYTMMGK QEESQAGIIP 130 140 150 160 170 180 QLCEELFEKI NDNCNEEMSY SVEVSYMEIY CERVRDLLNP KNKGNLRVRE HPLLGPYVED 190 200 210 220 230 240 LSKLAVTSYT DIADLMDAGN KARTVAATNM NETSSRSHAV FTIVFTQKKH DNETNLSTEK 250 260 270 280 290 300 VSKISLVDLA GSERADSTGA KGTRLKEGAN INKSLTTLGK VISALAEVSK KKKKTDFIPY 310 320 330 340 350 360 RDSVLTWLLR ENLGGNSRTA MVAALSPADI NYDETLSTLR YADRAKQIKC NAVINEDPNA 370 380 390 400 410 420 KLVRELKEEV TRLKDLLRAQ GLGDIIDTSM GSLTSSPSSC SLSSQVGLTS VTSIQERIMS 430 440 450 460 470 480 TPGGEEAIER LKESEKIIAE LNETWEEKLR KTEAIRMERE ALLAEMGVAI REDGGTLGVF 490 500 510 520 530 540 SPKKTPHLVN LNEDPLMSEC LLYYIKDGIT RVGQADAERR QDIVLSGAHI KEEHCIFRSE 550 560 570 580 590 600 RSNSGEVIVT LEPCERSETY VNGKRVSQPV QLRSGNRIIM GKNHVFRFNH PEQARAEREK 610 620 630 640 650 660 TPSAETPSEP VDWTFAQREL LEKQGIDMKQ EMEKRLQEME ILYKKEKEEA DLLLEQQRLD 670 680 690 700 710 720 ADSDSGDDSD KRSCEESWKL ITSLREKLPP SKLQTIVKKC GLPSSGKKRE PIKMYQIPQR 730 740 750 760 770 780 RRLSKDSKWV TISDLKIQAV KEICYEVALN DFRHSRQEIE ALAIVKMKEL CAMYGKKDPN 790 800 810 820 830 840 ERDSWRAVAR DVWDTVGVGD EKIEDVMATG KGSTDVDDLK VHIDKLEDIL QEVKKQNNMK 850 860 870 880 890 900 DEEIKVLRNK MLKMEKVLPL IGSQEQKSPG SHKAKEPVGA GVSSTSENNV SKGDNGELAK 910 920 930 940 950 960 EERVSQLMNG DPAFRRGRLR WMRQEQIRFK NLQQQEITKQ LRRQNVPHRF IPPENRKPRF 970 980 990 1000 1010 1020 PFKSNPKHRN SWSPGTHIII TEDEVIELRI PKDDEARKGN KEESQEKGGK GAFKDPQFPW 1030 1040 1050 1060 1070 1080 GSQGMRSQDH IQVSKQHINN QQQPPQLRWR SNSLNNGQPK STRCQASASA ESLNSHSGHP 1090 1100 1110 1120 1130 1140 TADVQTFQAK RHIHQHRQSY CNYNTGGQLE GNAATSYQKQ TDKPSHCSQF VTPPRMRRQF 1150 SAPNLKAGRE TTV « Hide
Isoform 4 [UniParc]. Checksum: A53CAAD5693880E7 Show »		1,823	205,140
10 20 30 40 50 60 MSGASVKVAV RVRPFNSRET SKESKCIIQM QGNSTSIINP KNPKEAPKSF SFDYSYWSHT 70 80 90 100 110 120 SPEDPCFASQ NRVYNDIGKE MLLHAFEGYN VCIFAYGQTG AGKSYTMMGK QEESQAGIIP 130 140 150 160 170 180 QLCEELFEKI NDNCNEEMSY SVEVSYMEIY CERVRDLLNP KNKGNLRVRE HPLLGPYVED 190 200 210 220 230 240 LSKLAVTSYT DIADLMDAGN KARTVAATNM NETSSRSHAV FTIVFTQKKH DNETNLSTEK 250 260 270 280 290 300 VSKISLVDLA GSERADSTGA KGTRLKEGAN INKSLTTLGK VISALAEVDN CTSKSKKKKK 310 320 330 340 350 360 TDFIPYRDSV LTWLLRENLG GNSRTAMVAA LSPADINYDE TLSTLRYADR AKQIKCNAVI 370 380 390 400 410 420 NEDPNAKLVR ELKEEVTRLK DLLRAQGLGD IIDIDPLIDD YSGSGSKYLK DFQNNKHRYL 430 440 450 460 470 480 LASENQRPGH FSTASMGSLT SSPSSCSLSS QVGLTSVTSI QERIMSTPGG EEAIERLKES 490 500 510 520 530 540 EKIIAELNET WEEKLRKTEA IRMEREALLA EMGVAIREDG GTLGVFSPKK TPHLVNLNED 550 560 570 580 590 600 PLMSECLLYY IKDGITRVGQ ADAERRQDIV LSGAHIKEEH CIFRSERSNS GEVIVTLEPC 610 620 630 640 650 660 ERSETYVNGK RVSQPVQLRS GNRIIMGKNH VFRFNHPEQA RAEREKTPSA ETPSEPVDWT 670 680 690 700 710 720 FAQRELLEKQ GIDMKQEMEK RLQEMEILYK KEKEEADLLL EQQRLDYESK LQALQKQVET 730 740 750 760 770 780 RSLAAETTEE EEEEEEVPWT QHEFELAQWA FRKWKSHQFT SLRDLLWGNA VYLKEANAIS 790 800 810 820 830 840 VELKKKVQFQ FVLLTDTLYS PLPPELLPTE MEKTHEDRPF PRTVVAVEVQ DLKNGATHYW 850 860 870 880 890 900 SLEKLKQRLD LMREMYDRAG EMASSAQDES ETTVTGSDPF YDRFHWFKLV GSSPIFHGCV 910 920 930 940 950 960 NERLADRTPS PTFSTADSDI TELADEQQDE MEDFDDEAFV DDAGSDAGTE EGSDLFSDGH 970 980 990 1000 1010 1020 DPFYDRSPWF ILVGRAFVYL SNLLYPVPLI HRVAIVSEKG EVRGFLRVAV QAIAADEEAP 1030 1040 1050 1060 1070 1080 DYGSGIRQSG TAKISFDNEY FNQSDFSSVA MTRSGLSLEE LRIVEGQGQS SEVITPPEEI 1090 1100 1110 1120 1130 1140 SRINDLDLKS STLLDGKMVM EGFSEEIGNH LKLGSAFTFR VTVLQASGIL PEYADIFCQF 1150 1160 1170 1180 1190 1200 NFLHRHDEAF STEPLKNNGR GSPLAFYHVQ NIAVEITESF VDYIKTKPIV FEVFGHYQQH 1210 1220 1230 1240 1250 1260 PLHLQGQELN SPPQPCRRFF PPPMPLSKPV PATKLNTMSK TSLGQSMSKY DLLVWFEISE 1270 1280 1290 1300 1310 1320 LEPTGEYIPA VVDHTAGLPC QGTFLLHQGI QRRITVTIIH EKGSELHWKD VRELVVGRIR 1330 1340 1350 1360 1370 1380 NKPEVDEAAV DAILSLNIIS AKYLKSSHNS SRTFYRFEAV WDSSLHNSLL LNRVTPYGEK 1390 1400 1410 1420 1430 1440 IYMTLSAYLE LDHCIQPAVI TKDVCMVFYS RDAKISPPRS LRSLFGSGYS KSPDSNRVTG 1450 1460 1470 1480 1490 1500 IYELSLCKMS DTGSPGMQRR RRKILDTSVA YVRGEENLAG WRPRGDSLIL EHQWELEKLE 1510 1520 1530 1540 1550 1560 LLHEVEKTRH FLLLRERLGD SIPKSLSDSL SPSLSSGTLS TSTSISSQIS TTTFESAITP 1570 1580 1590 1600 1610 1620 SESSGYDSGD IESLVDREKE LATKCLQLLT HTFNREFSQV HGSVSDCKLS DISPIGRDPS 1630 1640 1650 1660 1670 1680 ESSFSSATLT PSSTCPSLVD SRSNSLDQKT PEANSRASSP CPEFEQFQIV PAVETPYLAR 1690 1700 1710 1720 1730 1740 AGKNEFLNLV PDIEEIRPSS VVSKKGYLHF KEPLYSNWAK HFVVVRRPYV FIYNSDKDPV 1750 1760 1770 1780 1790 1800 ERGIINLSTA QVEYSEDQQA MVKTPNTFAV CTKHRGVLLQ ALNDKDMNDW LYAFNPLLAG 1810 1820 TIRPGHLASE IIREDKSVSF SCQ « Hide

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DNA encoding a kinesin-like protein (hklp) comprising biallelic markers." Bougueleret L., Dufaure-Gare I., Grel P. Patent number WO0063375, 26-OCT-2000 Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
[2]	"Identification of the full-length KIAA0591 gene encoding a novel kinesin-related protein which is mapped to the neuroblastoma suppressor gene locus at 1p36.2." Nagai M., Ichimiya S., Ozaki T., Seki N., Mihara M., Furuta S., Ohira M., Tomioka N., Nomura N., Sakiyama S., Kubo O., Takakura K., Hori T., Nakagawara A. Int. J. Oncol. 16:907-916(2000) [PubMed: 10762626] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), TISSUE SPECIFICITY. Tissue: Substantia nigra.
[3]	"Genomic structure and mutational analysis of the human KIF1B gene which is homozygously deleted in neuroblastoma at chromosome 1p36.2." Yang H.W., Chen Y.Z., Takita J., Soeda E., Piao H.Y., Hayashi Y. Oncogene 20:5075-5083(2001) [PubMed: 11526494] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2), TISSUE SPECIFICITY.
[4]	"Identification of the human ortholog of mouse Kif1B, a kinesin superfamily motor protein." Park M., Shin H., Lee Y.M., Moon E., Choi W.<

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Keywords

Gene Ontology (GO)

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Experimental info

Sequences

References