O60333 (KIF1B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kinesin-like protein KIF1B
Short name=Klp

Gene names

Name:	KIF1B
Synonyms:	KIAA0591, KIAA1448

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1816 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Motor for anterograde transport of mitochondria. Has a microtubule plus end-directed motility. Isoform 2 is required for induction of neuronal apoptosis. Ref.14
Subunit structure	Interacts (via C-terminus end of the kinesin-motor domain) with CHP1; the interaction occurs in a calcium-dependent manner By similarity. Interacts with KBP. Ref.13
Subcellular location	Cytoplasmic vesicle By similarity. Cytoplasm › cytoskeleton By similarity. Mitochondrion. Note: Colocalizes with synaptophysin at synaptic cytoplasmic transport vesicles in the neurites of hippocampal neurons By similarity. Ref.13
Tissue specificity	Isoform 3 is abundant in the skeletal muscle. It is also expressed in fetal brain, lung and kidney, and adult heart, placenta, testis, ovary and small intestine. Isoform 2 is abundant in the brain and also expressed in fetal heart, lung, liver and kidney, and adult skeletal muscle, placenta, liver, kidney, heart, spleen, thymus, prostate, testis, ovary, small intestine, colon and pancreas. Ref.2 Ref.3 Ref.6
Involvement in disease	Charcot-Marie-Tooth disease 2A1 (CMT2A1) [MIM:118210]: A dominant axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal regeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. Nerve conduction velocities are normal or slightly reduced. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.20 Neuroblastoma 1 (NBLST1) [MIM:256700]: A common neoplasm of early childhood arising from embryonic cells that form the primitive neural crest and give rise to the adrenal medulla and the sympathetic nervous system. Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Pheochromocytoma (PCC) [MIM:171300]: A catecholamine-producing tumor of chromaffin tissue of the adrenal medulla or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of epinephrine and norepinephrine, is hypertension, which may be persistent or intermittent. Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.
Sequence similarities	Belongs to the kinesin-like protein family. Unc-104 subfamily. Contains 1 FHA domain. Contains 1 kinesin-motor domain. Contains 1 PH domain.
Sequence caution	The sequence AAH01415.1 differs from that shown. Reason: Erroneous initiation. The sequence AAP35838.1 differs from that shown. Reason: Erroneous initiation. The sequence BAA25517.2 differs from that shown. Reason: Erroneous initiation. The sequence BAA95972.2 differs from that shown. Reason: Erroneous initiation. The sequence BAB69038.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Cytoplasm Cytoplasmic vesicle Cytoskeleton Microtubule Mitochondrion
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Charcot-Marie-Tooth disease Disease mutation Neuropathy
Domain	Coiled coil
Ligand	ATP-binding Nucleotide-binding
Molecular function	Motor protein
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	anterograde axon cargo transport Inferred from sequence or structural similarity. Source: UniProtKB apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW mitochondrion transport along microtubule Inferred from electronic annotation. Source: Compara neuromuscular synaptic transmission Inferred from sequence or structural similarity. Source: UniProtKB neuron-neuron synaptic transmission Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	cytoplasmic vesicle membrane Inferred from sequence or structural similarity. Source: UniProtKB microtubule Inferred from electronic annotation. Source: UniProtKB-KW microtubule associated complex Inferred from sequence or structural similarity. Source: UniProtKB mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell neuron projection Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity Inferred from sequence or structural similarity. Source: UniProtKB kinesin binding Traceable author statement PubMed 10341097. Source: UniProtKB microtubule motor activity Inferred from sequence or structural similarity. Source: UniProtKB phospholipid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
DLG1	Q12959	4	EBI-465669,EBI-357481
Dlg2	Q63622	3	EBI-465669,EBI-396947	From a different organism.
DLG4	P78352	4	EBI-465669,EBI-80389
MAGI1	Q96QZ7	3	EBI-465669,EBI-924464

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O60333-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O60333-2)

Also known as: Beta;

The sequence of this isoform differs from the canonical sequence as follows:
     289-294: Missing.
     394-434: IDPLIDDYSGSGSKYLKDFQNNKHRYLLASENQRPGHFSTA → T

Isoform 3 (identifier: O60333-3)

Also known as: Alpha;

The sequence of this isoform differs from the canonical sequence as follows:
     289-294: Missing.
     394-434: IDPLIDDYSGSGSKYLKDFQNNKHRYLLASENQRPGHFSTA → T
     707-1196: YESKLQALQK...KPIVFEVFGH → ADSDSGDDSD...NLKAGRETTV
     1197-1816: Missing.

Note: Contains a phosphoserine at position 1141. Contains a phosphoserine at position 663. Contains a phosphoserine at position 665.

Isoform 4 (identifier: O60333-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1804-1816: SKLSRRCPSQSKY → PGHLASEIIREDKSVSFSCQ

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1816

1816

Kinesin-like protein KIF1B

PRO_0000125407

Regions

Domain

1 – 361

361

Kinesin-motor

Domain

556 – 612

57

FHA

Domain

1702 – 1799

98

PH

Nucleotide binding

97 – 104

8

ATP By similarity

Region

270 – 350

81

Interaction with KBP

Coiled coil

365 – 386

22

Potential

Coiled coil

470 – 502

33

Potential

Coiled coil

668 – 737

70

Potential

Coiled coil

841 – 869

29

Potential

Amino acid modifications

Modified residue

1057

1

Phosphoserine Ref.15 Ref.17

Modified residue

1075

1

Phosphothreonine Ref.16

Modified residue

1454

1

Phosphoserine Ref.17

Modified residue

1487

1

Phosphoserine Ref.16 Ref.17

Modified residue

1610

1

Phosphoserine Ref.17

Modified residue

1613

1

Phosphoserine Ref.17

Natural variations

Alternative sequence

289 – 294

6

Missing in isoform 2 and isoform 3.

VSP_002858

Alternative sequence

394 – 434

41

IDPLI…HFSTA → T in isoform 2 and isoform 3.

VSP_002859

Alternative sequence

707 – 1196

490

YESKL…EVFGH → ADSDSGDDSDKRSCEESWKL ITSLREKLPPSKLQTIVKKC GLPSSGKKREPIKMYQIPQR RRLSKDSKWVTISDLKIQAV KEICYEVALNDFRHSRQEIE ALAIVKMKELCAMYGKKDPN ERDSWRAVARDVWDTVGVGD EKIEDVMATGKGSTDVDDLK VHIDKLEDILQEVKKQNNMK DEEIKVLRNKMLKMEKVLPL IGSQEQKSPGSHKAKEPVGA GVSSTSENNVSKGDNGELAK EERVSQLMNGDPAFRRGRLR WMRQEQIRFKNLQQQEITKQ LRRQNVPHRFIPPENRKPRF PFKSNPKHRNSWSPGTHIII TEDEVIELRIPKDDEARKGN KEESQEKGGKGAFKDPQFPW GSQGMRSQDHIQVSKQHINN QQQPPQLRWRSNSLNNGQPK STRCQASASAESLNSHSGHP TADVQTFQAKRHIHQHRQSY CNYNTGGQLEGNAATSYQKQ TDKPSHCSQFVTPPRMRRQF SAPNLKAGRETTV in isoform 3.

VSP_002860

Alternative sequence

1197 – 1816

620

Missing in isoform 3.

VSP_002861

Alternative sequence

1804 – 1816

13

SKLSR…SQSKY → PGHLASEIIREDKSVSFSCQ in isoform 4.

VSP_009381

Natural variant

34

1

S → L in a medulloblastoma sample; somatic mutation; loss of ability to induce apoptosis. Ref.14

VAR_063531

Natural variant

98

1

Q → L in CMT2A1. Ref.20

VAR_011515

Natural variant

692

1

E → V Confers susceptibility to neuroblastoma; found as germline mutation in a neuroblastoma patient; loss of ability to induce apoptosis. Ref.14

VAR_063532

Natural variant

873

1

T → I Confers susceptibility to neuroblastoma; found as germline mutation in a neuroblastoma patient; loss of ability to induce apoptosis. Ref.14

VAR_063533

Natural variant

1133

1

Y → C. Ref.14

VAR_063534

Natural variant

1263

1

P → S Confers susceptibility to neuroblastoma; found as germline mutation in a neuroblastoma patient; loss of ability to induce apoptosis. Ref.14

VAR_063535

Natural variant

1527

1

S → N Confers susceptibility to pheochromocytoma; found as germline mutation in a pheochromocytoma family; loss of ability to induce apoptosis. Ref.14

VAR_063536

Natural variant

1600

1

V → M. Ref.14

VAR_063537

Natural variant

1674

1

E → K in a pheochromocytoma sample; loss of ability to induce apoptosis. Ref.14

VAR_063538

Experimental info

Sequence conflict

87

1

E → G in BAA25517. Ref.8

Sequence conflict

129 – 131

3

KIN → TNH in AAK49332. Ref.3

Sequence conflict

129 – 131

3

KIN → TNH in AAK85155. Ref.4

Sequence conflict

129 – 131

3

KIN → TNH in AAN17742. Ref.5

Sequence conflict

170

1

E → D in AAK49332. Ref.3

Sequence conflict

170

1

E → D in AAK85155. Ref.4

Sequence conflict

170

1

E → D in AAN17742. Ref.5

Sequence conflict

174

1

L → R in AAK49332. Ref.3

Sequence conflict

174

1

L → R in AAK85155. Ref.4

Sequence conflict

174

1

L → R in AAN17742. Ref.5

Sequence conflict

219 – 221

3

AVF → VVY in AAK49332. Ref.3

Sequence conflict

219 – 221

3

AVF → VVY in AAK85155. Ref.4

Sequence conflict

219 – 221

3

AVF → VVY in AAN17742. Ref.5

Sequence conflict

235 – 239

5

NLSTE → ILATV in AAK49332. Ref.3

Sequence conflict

235 – 239

5

NLSTE → ILATV in AAK85155. Ref.4

Sequence conflict

235 – 239

5

NLSTE → ILATV in AAN17742. Ref.5

Sequence conflict

244

1

I → T in AAK49332. Ref.3

Sequence conflict

244

1

I → T in AAK85155. Ref.4

Sequence conflict

244

1

I → T in AAN17742. Ref.5

Sequence conflict

253

1

E → D in AAK49332. Ref.3

Sequence conflict

253

1

E → D in AAK85155. Ref.4

Sequence conflict

253

1

E → D in AAN17742. Ref.5

Sequence conflict

256

1

D → A in AAK49332. Ref.3

Sequence conflict

256

1

D → A in AAK85155. Ref.4

Sequence conflict

256

1

D → A in AAN17742. Ref.5

Sequence conflict

270

1

N → I in AAK49332. Ref.3

Sequence conflict

270

1

N → I in AAK85155. Ref.4

Sequence conflict

270

1

N → I in AAN17742. Ref.5

Sequence conflict

363

1

D → G in BAB69038. Ref.2

Secondary structure

1

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1816

Helix Strand Turn

Details...

Beta strand

533 – 535

3

Beta strand

547 – 550

4

Beta strand

553 – 559

7

Beta strand

563 – 565

3

Beta strand

568 – 570

3

Beta strand

573 – 575

3

Beta strand

580 – 587

8

Beta strand

593 – 597

5

Beta strand

601 – 603

3

Beta strand

605 – 607

3

Beta strand

625 – 629

5

Beta strand

633 – 635

3

Helix

637 – 640

4

Turn

641 – 645

5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 17, 2006. Version 5. Checksum: AD62F0515978C783	FASTA	1,816	204,476
	10 20 30 40 50 60 MSGASVKVAV RVRPFNSRET SKESKCIIQM QGNSTSIINP KNPKEAPKSF SFDYSYWSHT 70 80 90 100 110 120 SPEDPCFASQ NRVYNDIGKE MLLHAFEGYN VCIFAYGQTG AGKSYTMMGK QEESQAGIIP 130 140 150 160 170 180 QLCEELFEKI NDNCNEEMSY SVEVSYMEIY CERVRDLLNP KNKGNLRVRE HPLLGPYVED 190 200 210 220 230 240 LSKLAVTSYT DIADLMDAGN KARTVAATNM NETSSRSHAV FTIVFTQKKH DNETNLSTEK 250 260 270 280 290 300 VSKISLVDLA GSERADSTGA KGTRLKEGAN INKSLTTLGK VISALAEVDN CTSKSKKKKK 310 320 330 340 350 360 TDFIPYRDSV LTWLLRENLG GNSRTAMVAA LSPADINYDE TLSTLRYADR AKQIKCNAVI 370 380 390 400 410 420 NEDPNAKLVR ELKEEVTRLK DLLRAQGLGD IIDIDPLIDD YSGSGSKYLK DFQNNKHRYL 430 440 450 460 470 480 LASENQRPGH FSTASMGSLT SSPSSCSLSS QVGLTSVTSI QERIMSTPGG EEAIERLKES 490 500 510 520 530 540 EKIIAELNET WEEKLRKTEA IRMEREALLA EMGVAIREDG GTLGVFSPKK TPHLVNLNED 550 560 570 580 590 600 PLMSECLLYY IKDGITRVGQ ADAERRQDIV LSGAHIKEEH CIFRSERSNS GEVIVTLEPC 610 620 630 640 650 660 ERSETYVNGK RVSQPVQLRS GNRIIMGKNH VFRFNHPEQA RAEREKTPSA ETPSEPVDWT 670 680 690 700 710 720 FAQRELLEKQ GIDMKQEMEK RLQEMEILYK KEKEEADLLL EQQRLDYESK LQALQKQVET 730 740 750 760 770 780 RSLAAETTEE EEEEEEVPWT QHEFELAQWA FRKWKSHQFT SLRDLLWGNA VYLKEANAIS 790 800 810 820 830 840 VELKKKVQFQ FVLLTDTLYS PLPPELLPTE MEKTHEDRPF PRTVVAVEVQ DLKNGATHYW 850 860 870 880 890 900 SLEKLKQRLD LMREMYDRAG EMASSAQDES ETTVTGSDPF YDRFHWFKLV GSSPIFHGCV 910 920 930 940 950 960 NERLADRTPS PTFSTADSDI TELADEQQDE MEDFDDEAFV DDAGSDAGTE EGSDLFSDGH 970 980 990 1000 1010 1020 DPFYDRSPWF ILVGRAFVYL SNLLYPVPLI HRVAIVSEKG EVRGFLRVAV QAIAADEEAP 1030 1040 1050 1060 1070 1080 DYGSGIRQSG TAKISFDNEY FNQSDFSSVA MTRSGLSLEE LRIVEGQGQS SEVITPPEEI 1090 1100 1110 1120 1130 1140 SRINDLDLKS STLLDGKMVM EGFSEEIGNH LKLGSAFTFR VTVLQASGIL PEYADIFCQF 1150 1160 1170 1180 1190 1200 NFLHRHDEAF STEPLKNNGR GSPLAFYHVQ NIAVEITESF VDYIKTKPIV FEVFGHYQQH 1210 1220 1230 1240 1250 1260 PLHLQGQELN SPPQPCRRFF PPPMPLSKPV PATKLNTMSK TSLGQSMSKY DLLVWFEISE 1270 1280 1290 1300 1310 1320 LEPTGEYIPA VVDHTAGLPC QGTFLLHQGI QRRITVTIIH EKGSELHWKD VRELVVGRIR 1330 1340 1350 1360 1370 1380 NKPEVDEAAV DAILSLNIIS AKYLKSSHNS SRTFYRFEAV WDSSLHNSLL LNRVTPYGEK 1390 1400 1410 1420 1430 1440 IYMTLSAYLE LDHCIQPAVI TKDVCMVFYS RDAKISPPRS LRSLFGSGYS KSPDSNRVTG 1450 1460 1470 1480 1490 1500 IYELSLCKMS DTGSPGMQRR RRKILDTSVA YVRGEENLAG WRPRGDSLIL EHQWELEKLE 1510 1520 1530 1540 1550 1560 LLHEVEKTRH FLLLRERLGD SIPKSLSDSL SPSLSSGTLS TSTSISSQIS TTTFESAITP 1570 1580 1590 1600 1610 1620 SESSGYDSGD IESLVDREKE LATKCLQLLT HTFNREFSQV HGSVSDCKLS DISPIGRDPS 1630 1640 1650 1660 1670 1680 ESSFSSATLT PSSTCPSLVD SRSNSLDQKT PEANSRASSP CPEFEQFQIV PAVETPYLAR 1690 1700 1710 1720 1730 1740 AGKNEFLNLV PDIEEIRPSS VVSKKGYLHF KEPLYSNWAK HFVVVRRPYV FIYNSDKDPV 1750 1760 1770 1780 1790 1800 ERGIINLSTA QVEYSEDQQA MVKTPNTFAV CTKHRGVLLQ ALNDKDMNDW LYAFNPLLAG 1810 TIRSKLSRRC PSQSKY
	Isoform 2 (Beta) [UniParc]. Checksum: 8AE6BB2665AF702C	FASTA	1,770	199,263
	10 20 30 40 50 60 MSGASVKVAV RVRPFNSRET SKESKCIIQM QGNSTSIINP KNPKEAPKSF SFDYSYWSHT 70 80 90 100 110 120 SPEDPCFASQ NRVYNDIGKE MLLHAFEGYN VCIFAYGQTG AGKSYTMMGK QEESQAGIIP 130 140 150 160 170 180 QLCEELFEKI NDNCNEEMSY SVEVSYMEIY CERVRDLLNP KNKGNLRVRE HPLLGPYVED 190 200 210 220 230 240 LSKLAVTSYT DIADLMDAGN KARTVAATNM NETSSRSHAV FTIVFTQKKH DNETNLSTEK 250 260 270 280 290 300 VSKISLVDLA GSERADSTGA KGTRLKEGAN INKSLTTLGK VISALAEVSK KKKKTDFIPY 310 320 330 340 350 360 RDSVLTWLLR ENLGGNSRTA MVAALSPADI NYDETLSTLR YADRAKQIKC NAVINEDPNA 370 380 390 400 410 420 KLVRELKEEV TRLKDLLRAQ GLGDIIDTSM GSLTSSPSSC SLSSQVGLTS VTSIQERIMS 430 440 450 460 470 480 TPGGEEAIER LKESEKIIAE LNETWEEKLR KTEAIRMERE ALLAEMGVAI REDGGTLGVF 490 500 510 520 530 540 SPKKTPHLVN LNEDPLMSEC LLYYIKDGIT RVGQADAERR QDIVLSGAHI KEEHCIFRSE 550 560 570 580 590 600 RSNSGEVIVT LEPCERSETY VNGKRVSQPV QLRSGNRIIM GKNHVFRFNH PEQARAEREK 610 620 630 640 650 660 TPSAETPSEP VDWTFAQREL LEKQGIDMKQ EMEKRLQEME ILYKKEKEEA DLLLEQQRLD 670 680 690 700 710 720 YESKLQALQK QVETRSLAAE TTEEEEEEEE VPWTQHEFEL AQWAFRKWKS HQFTSLRDLL 730 740 750 760 770 780 WGNAVYLKEA NAISVELKKK VQFQFVLLTD TLYSPLPPEL LPTEMEKTHE DRPFPRTVVA 790 800 810 820 830 840 VEVQDLKNGA THYWSLEKLK QRLDLMREMY DRAGEMASSA QDESETTVTG SDPFYDRFHW 850 860 870 880 890 900 FKLVGSSPIF HGCVNERLAD RTPSPTFSTA DSDITELADE QQDEMEDFDD EAFVDDAGSD 910 920 930 940 950 960 AGTEEGSDLF SDGHDPFYDR SPWFILVGRA FVYLSNLLYP VPLIHRVAIV SEKGEVRGFL 970 980 990 1000 1010 1020 RVAVQAIAAD EEAPDYGSGI RQSGTAKISF DNEYFNQSDF SSVAMTRSGL SLEELRIVEG 1030 1040 1050 1060 1070 1080 QGQSSEVITP PEEISRINDL DLKSSTLLDG KMVMEGFSEE IGNHLKLGSA FTFRVTVLQA 1090 1100 1110 1120 1130 1140 SGILPEYADI FCQFNFLHRH DEAFSTEPLK NNGRGSPLAF YHVQNIAVEI TESFVDYIKT 1150 1160 1170 1180 1190 1200 KPIVFEVFGH YQQHPLHLQG QELNSPPQPC RRFFPPPMPL SKPVPATKLN TMSKTSLGQS 1210 1220 1230 1240 1250 1260 MSKYDLLVWF EISELEPTGE YIPAVVDHTA GLPCQGTFLL HQGIQRRITV TIIHEKGSEL 1270 1280 1290 1300 1310 1320 HWKDVRELVV GRIRNKPEVD EAAVDAILSL NIISAKYLKS SHNSSRTFYR FEAVWDSSLH 1330 1340 1350 1360 1370 1380 NSLLLNRVTP YGEKIYMTLS AYLELDHCIQ PAVITKDVCM VFYSRDAKIS PPRSLRSLFG 1390 1400 1410 1420 1430 1440 SGYSKSPDSN RVTGIYELSL CKMSDTGSPG MQRRRRKILD TSVAYVRGEE NLAGWRPRGD 1450 1460 1470 1480 1490 1500 SLILEHQWEL EKLELLHEVE KTRHFLLLRE RLGDSIPKSL SDSLSPSLSS GTLSTSTSIS 1510 1520 1530 1540 1550 1560 SQISTTTFES AITPSESSGY DSGDIESLVD REKELATKCL QLLTHTFNRE FSQVHGSVSD 1570 1580 1590 1600 1610 1620 CKLSDISPIG RDPSESSFSS ATLTPSSTCP SLVDSRSNSL DQKTPEANSR ASSPCPEFEQ 1630 1640 1650 1660 1670 1680 FQIVPAVETP YLARAGKNEF LNLVPDIEEI RPSSVVSKKG YLHFKEPLYS NWAKHFVVVR 1690 1700 1710 1720 1730 1740 RPYVFIYNSD KDPVERGIIN LSTAQVEYSE DQQAMVKTPN TFAVCTKHRG VLLQALNDKD 1750 1760 1770 MNDWLYAFNP LLAGTIRSKL SRRCPSQSKY
	Isoform 3 (Alpha) [UniParc]. Checksum: 6F0D8846CD283811	FASTA	1,153	130,363
	10 20 30 40 50 60 MSGASVKVAV RVRPFNSRET SKESKCIIQM QGNSTSIINP KNPKEAPKSF SFDYSYWSHT 70 80 90 100 110 120 SPEDPCFASQ NRVYNDIGKE MLLHAFEGYN VCIFAYGQTG AGKSYTMMGK QEESQAGIIP 130 140 150 160 170 180 QLCEELFEKI NDNCNEEMSY SVEVSYMEIY CERVRDLLNP KNKGNLRVRE HPLLGPYVED 190 200 210 220 230 240 LSKLAVTSYT DIADLMDAGN KARTVAATNM NETSSRSHAV FTIVFTQKKH DNETNLSTEK 250 260 270 280 290 300 VSKISLVDLA GSERADSTGA KGTRLKEGAN INKSLTTLGK VISALAEVSK KKKKTDFIPY 310 320 330 340 350 360 RDSVLTWLLR ENLGGNSRTA MVAALSPADI NYDETLSTLR YADRAKQIKC NAVINEDPNA 370 380 390 400 410 420 KLVRELKEEV TRLKDLLRAQ GLGDIIDTSM GSLTSSPSSC SLSSQVGLTS VTSIQERIMS 430 440 450 460 470 480 TPGGEEAIER LKESEKIIAE LNETWEEKLR KTEAIRMERE ALLAEMGVAI REDGGTLGVF 490 500 510 520 530 540 SPKKTPHLVN LNEDPLMSEC LLYYIKDGIT RVGQADAERR QDIVLSGAHI KEEHCIFRSE 550 560 570 580 590 600 RSNSGEVIVT LEPCERSETY VNGKRVSQPV QLRSGNRIIM GKNHVFRFNH PEQARAEREK 610 620 630 640 650 660 TPSAETPSEP VDWTFAQREL LEKQGIDMKQ EMEKRLQEME ILYKKEKEEA DLLLEQQRLD 670 680 690 700 710 720 ADSDSGDDSD KRSCEESWKL ITSLREKLPP SKLQTIVKKC GLPSSGKKRE PIKMYQIPQR 730 740 750 760 770 780 RRLSKDSKWV TISDLKIQAV KEICYEVALN DFRHSRQEIE ALAIVKMKEL CAMYGKKDPN 790 800 810 820 830 840 ERDSWRAVAR DVWDTVGVGD EKIEDVMATG KGSTDVDDLK VHIDKLEDIL QEVKKQNNMK 850 860 870 880 890 900 DEEIKVLRNK MLKMEKVLPL IGSQEQKSPG SHKAKEPVGA GVSSTSENNV SKGDNGELAK 910 920 930 940 950 960 EERVSQLMNG DPAFRRGRLR WMRQEQIRFK NLQQQEITKQ LRRQNVPHRF IPPENRKPRF 970 980 990 1000 1010 1020 PFKSNPKHRN SWSPGTHIII TEDEVIELRI PKDDEARKGN KEESQEKGGK GAFKDPQFPW 1030 1040 1050 1060 1070 1080 GSQGMRSQDH IQVSKQHINN QQQPPQLRWR SNSLNNGQPK STRCQASASA ESLNSHSGHP 1090 1100 1110 1120 1130 1140 TADVQTFQAK RHIHQHRQSY CNYNTGGQLE GNAATSYQKQ TDKPSHCSQF VTPPRMRRQF 1150 SAPNLKAGRE TTV
	Isoform 4 [UniParc]. Checksum: A53CAAD5693880E7	FASTA	1,823	205,140
	10 20 30 40 50 60 MSGASVKVAV RVRPFNSRET SKESKCIIQM QGNSTSIINP KNPKEAPKSF SFDYSYWSHT 70 80 90 100 110 120 SPEDPCFASQ NRVYNDIGKE MLLHAFEGYN VCIFAYGQTG AGKSYTMMGK QEESQAGIIP 130 140 150 160 170 180 QLCEELFEKI NDNCNEEMSY SVEVSYMEIY CERVRDLLNP KNKGNLRVRE HPLLGPYVED 190 200 210 220 230 240 LSKLAVTSYT DIADLMDAGN KARTVAATNM NETSSRSHAV FTIVFTQKKH DNETNLSTEK 250 260 270 280 290 300 VSKISLVDLA GSERADSTGA KGTRLKEGAN INKSLTTLGK VISALAEVDN CTSKSKKKKK 310 320 330 340 350 360 TDFIPYRDSV LTWLLRENLG GNSRTAMVAA LSPADINYDE TLSTLRYADR AKQIKCNAVI 370 380 390 400 410 420 NEDPNAKLVR ELKEEVTRLK DLLRAQGLGD IIDIDPLIDD YSGSGSKYLK DFQNNKHRYL 430 440 450 460 470 480 LASENQRPGH FSTASMGSLT SSPSSCSLSS QVGLTSVTSI QERIMSTPGG EEAIERLKES 490 500 510 520 530 540 EKIIAELNET WEEKLRKTEA IRMEREALLA EMGVAIREDG GTLGVFSPKK TPHLVNLNED 550 560 570 580 590 600 PLMSECLLYY IKDGITRVGQ ADAERRQDIV LSGAHIKEEH CIFRSERSNS GEVIVTLEPC 610 620 630 640 650 660 ERSETYVNGK RVSQPVQLRS GNRIIMGKNH VFRFNHPEQA RAEREKTPSA ETPSEPVDWT 670 680 690 700 710 720 FAQRELLEKQ GIDMKQEMEK RLQEMEILYK KEKEEADLLL EQQRLDYESK LQALQKQVET 730 740 750 760 770 780 RSLAAETTEE EEEEEEVPWT QHEFELAQWA FRKWKSHQFT SLRDLLWGNA VYLKEANAIS 790 800 810 820 830 840 VELKKKVQFQ FVLLTDTLYS PLPPELLPTE MEKTHEDRPF PRTVVAVEVQ DLKNGATHYW 850 860 870 880 890 900 SLEKLKQRLD LMREMYDRAG EMASSAQDES ETTVTGSDPF YDRFHWFKLV GSSPIFHGCV 910 920 930 940 950 960 NERLADRTPS PTFSTADSDI TELADEQQDE MEDFDDEAFV DDAGSDAGTE EGSDLFSDGH 970 980 990 1000 1010 1020 DPFYDRSPWF ILVGRAFVYL SNLLYPVPLI HRVAIVSEKG EVRGFLRVAV QAIAADEEAP 1030 1040 1050 1060 1070 1080 DYGSGIRQSG TAKISFDNEY FNQSDFSSVA MTRSGLSLEE LRIVEGQGQS SEVITPPEEI 1090 1100 1110 1120 1130 1140 SRINDLDLKS STLLDGKMVM EGFSEEIGNH LKLGSAFTFR VTVLQASGIL PEYADIFCQF 1150 1160 1170 1180 1190 1200 NFLHRHDEAF STEPLKNNGR GSPLAFYHVQ NIAVEITESF VDYIKTKPIV FEVFGHYQQH 1210 1220 1230 1240 1250 1260 PLHLQGQELN SPPQPCRRFF PPPMPLSKPV PATKLNTMSK TSLGQSMSKY DLLVWFEISE 1270 1280 1290 1300 1310 1320 LEPTGEYIPA VVDHTAGLPC QGTFLLHQGI QRRITVTIIH EKGSELHWKD VRELVVGRIR 1330 1340 1350 1360 1370 1380 NKPEVDEAAV DAILSLNIIS AKYLKSSHNS SRTFYRFEAV WDSSLHNSLL LNRVTPYGEK 1390 1400 1410 1420 1430 1440 IYMTLSAYLE LDHCIQPAVI TKDVCMVFYS RDAKISPPRS LRSLFGSGYS KSPDSNRVTG 1450 1460 1470 1480 1490 1500 IYELSLCKMS DTGSPGMQRR RRKILDTSVA YVRGEENLAG WRPRGDSLIL EHQWELEKLE 1510 1520 1530 1540 1550 1560 LLHEVEKTRH FLLLRERLGD SIPKSLSDSL SPSLSSGTLS TSTSISSQIS TTTFESAITP 1570 1580 1590 1600 1610 1620 SESSGYDSGD IESLVDREKE LATKCLQLLT HTFNREFSQV HGSVSDCKLS DISPIGRDPS 1630 1640 1650 1660 1670 1680 ESSFSSATLT PSSTCPSLVD SRSNSLDQKT PEANSRASSP CPEFEQFQIV PAVETPYLAR 1690 1700 1710 1720 1730 1740 AGKNEFLNLV PDIEEIRPSS VVSKKGYLHF KEPLYSNWAK HFVVVRRPYV FIYNSDKDPV 1750 1760 1770 1780 1790 1800 ERGIINLSTA QVEYSEDQQA MVKTPNTFAV CTKHRGVLLQ ALNDKDMNDW LYAFNPLLAG 1810 1820 TIRPGHLASE IIREDKSVSF SCQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DNA encoding a kinesin-like protein (hklp) comprising biallelic markers." Bougueleret L., Dufaure-Gare I., Grel P. Patent number WO0063375, 26-OCT-2000 Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
[2]	"Identification of the full-length KIAA0591 gene encoding a novel kinesin-related protein which is mapped to the neuroblastoma suppressor gene locus at 1p36.2." Nagai M., Ichimiya S., Ozaki T., Seki N., Mihara M., Furuta S., Ohira M., Tomioka N., Nomura N., Sakiyama S., Kubo O., Takakura K., Hori T., Nakagawara A. Int. J. Oncol. 16:907-916(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), TISSUE SPECIFICITY. Tissue: Substantia nigra.
[3]	"Genomic structure and mutational analysis of the human KIF1B gene which is homozygously deleted in neuroblastoma at chromosome 1p36.2." Yang H.W., Chen Y.Z., Takita J., Soeda E., Piao H.Y., Hayashi Y. Oncogene 20:5075-5083(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2), TISSUE SPECIFICITY.
[4]	"Identification of the human ortholog of mouse Kif1B, a kinesin superfamily motor protein." Park M., Shin H., Lee Y.M., Moon E., Choi W., Kim W. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
[5]	"Identification of splicing variants of KIF1Bbeta." Munirajan A.K., Ohira M., Nakagawara A. Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
[6]	"Genomic structure and mutational analysis of the human KIF1Balpha gene located at 1p36.2 in neuroblastoma." Chen Y.Y., Takita J., Chen Y.Z., Yang H.W., Hanada R., Yamamoto K., Hayashi Y. Int. J. Oncol. 23:737-744(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY. Tissue: Neuroblastoma.
[7]	"Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[8]	"Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Brain.
[9]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[10]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1238-1816 (ISOFORMS 1/2). Tissue: Placenta.
[11]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1238-1816 (ISOFORMS 1/2).
[12]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1449-1816 (ISOFORMS 1/2).
[13]	"The novel protein KBP regulates mitochondria localization by interaction with a kinesin-like protein." Wozniak M.J., Melzer M., Dorner C., Haring H.U., Lammers R. BMC Cell Biol. 6:35-35(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH KBP, SUBCELLULAR LOCATION.
[14]	"The kinesin KIF1Bbeta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor." Schlisio S., Kenchappa R.S., Vredeveld L.C., George R.E., Stewart R., Greulich H., Shahriari K., Nguyen N.V., Pigny P., Dahia P.L., Pomeroy S.L., Maris J.M., Look A.T., Meyerson M., Peeper D.S., Carter B.D., Kaelin W.G. Jr. Genes Dev. 22:884-893(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INVOLVEMENT IN NEUROBLASTOMA AND PHEOCHROMOCYTOMA, VARIANTS LEU-34; VAL-692; ILE-873; CYS-1133; SER-1263; ASN-1527; MET-1600 AND LYS-1674.
[15]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1057, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[16]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1075 AND SER-1487, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[17]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1057; SER-1454; SER-1487; SER-1610 AND SER-1613, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1141 (ISOFORM 3), MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[18]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[19]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-663 AND SER-665 (ISOFORM 3), MASS SPECTROMETRY.
[20]	"Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1B-beta." Zhao C., Takita J., Tanaka Y., Setou M., Nakagawa T., Takeda S., Yang H.W., Terada S., Nakata T., Takei Y., Saito M., Tsuji S., Hayashi Y., Hirokawa N. Cell 105:587-597(2001) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT CMT2A1 LEU-98.
+	Additional computationally mapped references.

Web resources

Inherited peripheral neuropathies mutation db

GeneReviews

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AX039604 Genomic DNA. Translation: CAC16629.1.
AB017133 mRNA. Translation: BAB69038.1. Different initiation.
AF257176 mRNA. Translation: AAK49332.1.
AY043362 mRNA. Translation: AAK85155.1.
AB088210 mRNA. Translation: BAE02543.1.
AY139835 mRNA. Translation: AAN17742.1.
AB011163 mRNA. Translation: BAA25517.2. Different initiation.
AB040881 mRNA. Translation: BAA95972.2. Different initiation.
AL139424, AL358013 Genomic DNA. Translation: CAI95752.1.
AL139424, AL358013 Genomic DNA. Translation: CAI95753.1.
AL358013, AL139424 Genomic DNA. Translation: CAI95219.1.
AL358013, AL139424 Genomic DNA. Translation: CAI95220.1.
AL358013, AL139424 Genomic DNA. Translation: CAI95221.1.
AL358013 Genomic DNA. Translation: CAI95222.1.
AL139424, AL358013 Genomic DNA. Translation: CAI95754.1.
BC001415 mRNA. Translation: AAH01415.1. Different initiation.
BC115395 mRNA. Translation: AAI15396.1.
BT007174 mRNA. Translation: AAP35838.1. Different initiation.
AK022977 mRNA. Translation: BAB14341.1.

IPI

IPI00029011.
IPI00216252.
IPI00397383.
IPI00411763.

RefSeq

NP_055889.2. NM_015074.3.
NP_904325.2. NM_183416.3.

UniGene

Hs.97858.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2EH0	NMR	-	A	531-647	[»]

ProteinModelPortal

O60333.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-33015N.

IntAct

O60333. 19 interactions.

MINT

MINT-1682229.

PTM databases

PhosphoSite

O60333.

Proteomic databases

PaxDb

O60333.

PRIDE

O60333.

Protocols and materials databases

DNASU

23095.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000263934; ENSP00000263934; ENSG00000054523.
ENST00000377081; ENSP00000366284; ENSG00000054523.
ENST00000377083; ENSP00000366287; ENSG00000054523.
ENST00000377086; ENSP00000366290; ENSG00000054523.
ENST00000377093; ENSP00000366297; ENSG00000054523.

GeneID

23095.

KEGG

hsa:23095.

UCSC

uc001aqv.4. human.
uc001aqw.4. human.
uc001aqx.4. human.

Organism-specific databases

CTD

23095.

GeneCards

GC01P010270.

HGNC

HGNC:16636. KIF1B.

HPA

CAB015177.
HPA026434.

MIM

118210. phenotype.
171300. phenotype.
256700. phenotype.
605995. gene.

neXtProt

NX_O60333.

Orphanet

99946. Autosomal dominant Charcot-Marie-Tooth disease type 2A1.

PharmGKB

PA38176.

HUGE

Search...
Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG5059.

HOVERGEN

HBG052251.

KO

K10392.

OMA

GQSMSKY.

Gene expression databases

ArrayExpress

O60333.

Bgee

O60333.

CleanEx

HS_KIF1B.

Genevestigator

O60333.

GermOnline

ENSG00000054523. Homo sapiens.

Family and domain databases

Gene3D

2.30.29.30. 1 hit.
2.60.200.20. 1 hit.
3.40.850.10. 1 hit.

InterPro

IPR000253. FHA_dom.
IPR022140. KIF1B.
IPR022164. Kinesin-like.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR011993. PH_like_dom.
IPR001849. Pleckstrin_homology.
IPR008984. SMAD_FHA_domain.
[Graphical view]

Pfam

PF12473. DUF3694. 1 hit.
PF00498. FHA. 1 hit.
PF12423. KIF1B. 1 hit.
PF00225. Kinesin. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]

PRINTS

PR00380. KINESINHEAVY.

SMART

SM00240. FHA. 1 hit.
SM00129. KISc. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]

SUPFAM

SSF49879. SMAD_FHA. 1 hit.

PROSITE

PS50006. FHA_DOMAIN. 1 hit.
PS00411. KINESIN_MOTOR_DOMAIN1. 1 hit.
PS50067. KINESIN_MOTOR_DOMAIN2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

BindingDB

O60333.

ChEMBL

CHEMBL5889.

ChiTaRS

KIF1B. human.

EvolutionaryTrace

O60333.

GenomeRNAi

23095.

NextBio

44259.

SOURCE

Search...

Entry information

Entry name

KIF1B_HUMAN

Accession

Primary (citable) accession number: O60333
Secondary accession number(s): A6NFS8 , A6NKQ4, Q4VXC3, Q4VXC4, Q4VXC5, Q4VXC6, Q96Q94, Q9BV80, Q9P280

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	October 17, 2006
Last modified:	May 1, 2013
This is version 143 of the entry and version 5 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.