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O60330

- PCDGC_HUMAN

UniProt

O60330 - PCDGC_HUMAN

Protein

Protocadherin gamma-A12

Gene

PCDHGA12

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. homophilic cell adhesion Source: InterPro

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protocadherin gamma-A12
    Short name:
    PCDH-gamma-A12
    Alternative name(s):
    Cadherin-21
    Fibroblast cadherin-3
    Gene namesi
    Name:PCDHGA12
    Synonyms:CDH21, FIB3, KIAA0588
    ORF Names:UNQ371/PRO707
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:8699. PCDHGA12.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33047.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Chaini30 – 932903Protocadherin gamma-A12PRO_0000003970Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi265 – 2651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi419 – 4191N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi545 – 5451N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiO60330.
    PRIDEiO60330.

    PTM databases

    PhosphoSiteiO60330.

    Expressioni

    Gene expression databases

    BgeeiO60330.
    GenevestigatoriO60330.

    Organism-specific databases

    HPAiHPA008755.

    Interactioni

    Protein-protein interaction databases

    BioGridi117494. 1 interaction.
    STRINGi9606.ENSP00000252085.

    Structurei

    3D structure databases

    ProteinModelPortaliO60330.
    SMRiO60330. Positions 27-666.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini30 – 692663ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini714 – 932219CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei693 – 71321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 133104Cadherin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini134 – 242109Cadherin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini243 – 347105Cadherin 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini348 – 452105Cadherin 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini453 – 562110Cadherin 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini570 – 683114Cadherin 6PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 6 cadherin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG256872.
    HOGENOMiHOG000220892.
    HOVERGENiHBG054878.
    KOiK16495.
    OMAiREEKAIH.
    OrthoDBiEOG7KSX80.
    PhylomeDBiO60330.
    TreeFamiTF332299.

    Family and domain databases

    Gene3Di2.60.40.60. 6 hits.
    InterProiIPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR013164. Cadherin_N.
    [Graphical view]
    PfamiPF00028. Cadherin. 5 hits.
    PF08266. Cadherin_2. 1 hit.
    [Graphical view]
    PRINTSiPR00205. CADHERIN.
    SMARTiSM00112. CA. 6 hits.
    [Graphical view]
    SUPFAMiSSF49313. SSF49313. 6 hits.
    PROSITEiPS00232. CADHERIN_1. 5 hits.
    PS50268. CADHERIN_2. 6 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O60330-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MIPARLHRDY KGLVLLGILL GTLWETGCTQ IRYSVPEELE KGSRVGDISR    50
    DLGLEPRELA ERGVRIIPRG RTQLFALNPR SGSLVTAGRI DREELCMGAI 100
    KCQLNLDILM EDKVKIYGVE VEVRDINDNA PYFRESELEI KISENAATEM 150
    RFPLPHAWDP DIGKNSLQSY ELSPNTHFSL IVQNGADGSK YPELVLKRAL 200
    DREEKAAHHL VLTASDGGDP VRTGTARIRV MVLDANDNAP AFAQPEYRAS 250
    VPENLALGTQ LLVVNATDPD EGVNAEVRYS FRYVDDKAAQ VFKLDCNSGT 300
    ISTIGELDHE ESGFYQMEVQ AMDNAGYSAR AKVLITVLDV NDNAPEVVLT 350
    SLASSVPENS PRGTLIALLN VNDQDSEENG QVICFIQGNL PFKLEKSYGN 400
    YYSLVTDIVL DREQVPSYNI TVTATDRGTP PLSTETHISL NVADTNDNPP 450
    VFPQASYSAY IPENNPRGVS LVSVTAHDPD CEENAQITYS LAENTIQGAS 500
    LSSYVSINSD TGVLYALSSF DYEQFRDLQV KVMARDNGHP PLSSNVSLSL 550
    FVLDQNDNAP EILYPALPTD GSTGVELAPR SAEPGYLVTK VVAVDRDSGQ 600
    NAWLSYRLLK ASEPGLFSVG LHTGEVRTAR ALLDRDALKQ SLVVAVQDHG 650
    QPPLSATVTL TVAVADSIPQ VLADLGSLES PANSETSDLT LYLVVAVAAV 700
    SCVFLAFVIL LLALRLRRWH KSRLLQASGG GLTGAPASHF VGVDGVQAFL 750
    QTYSHEVSLT TDSRKSHLIF PQPNYADMLV SQESFEKSEP LLLSGDSVFS 800
    KDSHGLIEQA PPNTDWRFSQ AQRPGTSGSQ NGDDTGTWPN NQFDTEMLQA 850
    MILASASEAA DGSSTLGGGA GTMGLSARYG PQFTLQHVPD YRQNVYIPGS 900
    NATLTNAAGK RDGKAPAGGN GNKKKSGKKE KK 932
    Length:932
    Mass (Da):100,955
    Last modified:August 1, 1998 - v1
    Checksum:i8BDA90084785D746
    GO
    Isoform 2 (identifier: O60330-2) [UniParc]FASTAAdd to Basket

    Also known as: Short

    The sequence of this isoform differs from the canonical sequence as follows:
         809-820: QAPPNTDWRFSQ → VSLYQIFFLFFF
         821-932: Missing.

    Show »
    Length:820
    Mass (Da):89,582
    Checksum:i5ED08F61B9BA30FB
    GO

    Sequence cautioni

    The sequence AAQ89305.1 differs from that shown. Reason: Probable cloning artifact.
    The sequence BAA25514.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti331 – 3311A → P in BAA21135. (PubMed:9199196)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei809 – 82012QAPPN…WRFSQ → VSLYQIFFLFFF in isoform 2. 1 PublicationVSP_008682Add
    BLAST
    Alternative sequencei821 – 932112Missing in isoform 2. 1 PublicationVSP_008683Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF152321 mRNA. Translation: AAD43715.1.
    AF152506 mRNA. Translation: AAD43767.1.
    AB011160 mRNA. Translation: BAA25514.2. Different initiation.
    AY358946 mRNA. Translation: AAQ89305.1. Sequence problems.
    AB000897 mRNA. Translation: BAA21135.1.
    CCDSiCCDS4260.1. [O60330-1]
    PIRiPC4299.
    RefSeqiNP_003726.1. NM_003735.2. [O60330-1]
    NP_115265.1. NM_032094.1. [O60330-2]
    UniGeneiHs.368160.

    Genome annotation databases

    EnsembliENST00000252085; ENSP00000252085; ENSG00000253159. [O60330-1]
    GeneIDi26025.
    KEGGihsa:26025.
    UCSCiuc003lkt.2. human. [O60330-1]
    uc011dba.2. human. [O60330-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF152321 mRNA. Translation: AAD43715.1 .
    AF152506 mRNA. Translation: AAD43767.1 .
    AB011160 mRNA. Translation: BAA25514.2 . Different initiation.
    AY358946 mRNA. Translation: AAQ89305.1 . Sequence problems.
    AB000897 mRNA. Translation: BAA21135.1 .
    CCDSi CCDS4260.1. [O60330-1 ]
    PIRi PC4299.
    RefSeqi NP_003726.1. NM_003735.2. [O60330-1 ]
    NP_115265.1. NM_032094.1. [O60330-2 ]
    UniGenei Hs.368160.

    3D structure databases

    ProteinModelPortali O60330.
    SMRi O60330. Positions 27-666.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117494. 1 interaction.
    STRINGi 9606.ENSP00000252085.

    PTM databases

    PhosphoSitei O60330.

    Proteomic databases

    PaxDbi O60330.
    PRIDEi O60330.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000252085 ; ENSP00000252085 ; ENSG00000253159 . [O60330-1 ]
    GeneIDi 26025.
    KEGGi hsa:26025.
    UCSCi uc003lkt.2. human. [O60330-1 ]
    uc011dba.2. human. [O60330-2 ]

    Organism-specific databases

    CTDi 26025.
    GeneCardsi GC05P141298.
    HGNCi HGNC:8699. PCDHGA12.
    HPAi HPA008755.
    MIMi 603059. gene.
    604968. gene.
    neXtProti NX_O60330.
    PharmGKBi PA33047.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG256872.
    HOGENOMi HOG000220892.
    HOVERGENi HBG054878.
    KOi K16495.
    OMAi REEKAIH.
    OrthoDBi EOG7KSX80.
    PhylomeDBi O60330.
    TreeFami TF332299.

    Miscellaneous databases

    GeneWikii PCDHGA12.
    GenomeRNAii 26025.
    NextBioi 47808.
    PROi O60330.
    SOURCEi Search...

    Gene expression databases

    Bgeei O60330.
    Genevestigatori O60330.

    Family and domain databases

    Gene3Di 2.60.40.60. 6 hits.
    InterProi IPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR013164. Cadherin_N.
    [Graphical view ]
    Pfami PF00028. Cadherin. 5 hits.
    PF08266. Cadherin_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00205. CADHERIN.
    SMARTi SM00112. CA. 6 hits.
    [Graphical view ]
    SUPFAMi SSF49313. SSF49313. 6 hits.
    PROSITEi PS00232. CADHERIN_1. 5 hits.
    PS50268. CADHERIN_2. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A striking organization of a large family of human neural cadherin-like cell adhesion genes."
      Wu Q., Maniatis T.
      Cell 97:779-790(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain.
    2. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-808.
    4. "Multiple cadherins are expressed in human fibroblasts."
      Matsuyoshi N., Imamura S.
      Biochem. Biophys. Res. Commun. 235:355-358(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 311-444.

    Entry informationi

    Entry nameiPCDGC_HUMAN
    AccessioniPrimary (citable) accession number: O60330
    Secondary accession number(s): O15100, Q6UW70, Q9Y5D7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 24, 2003
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3