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Protein

Protocadherin gamma-A12

Gene

PCDHGA12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin gamma-A12
Short name:
PCDH-gamma-A12
Alternative name(s):
Cadherin-21
Fibroblast cadherin-3
Gene namesi
Name:PCDHGA12
Synonyms:CDH21, FIB3, KIAA0588
ORF Names:UNQ371/PRO707
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:8699. PCDHGA12.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 692ExtracellularSequence analysisAdd BLAST663
Transmembranei693 – 713HelicalSequence analysisAdd BLAST21
Topological domaini714 – 932CytoplasmicSequence analysisAdd BLAST219

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000253159.
PharmGKBiPA33047.

Polymorphism and mutation databases

BioMutaiPCDHGA12.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000000397030 – 932Protocadherin gamma-A12Add BLAST903

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi265N-linked (GlcNAc...)Sequence analysis1
Glycosylationi419N-linked (GlcNAc...)Sequence analysis1
Glycosylationi545N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiO60330.
MaxQBiO60330.
PaxDbiO60330.
PeptideAtlasiO60330.
PRIDEiO60330.

PTM databases

iPTMnetiO60330.
PhosphoSitePlusiO60330.

Expressioni

Gene expression databases

BgeeiENSG00000253159.
GenevisibleiO60330. HS.

Organism-specific databases

HPAiHPA008755.

Interactioni

Protein-protein interaction databases

BioGridi117494. 2 interactors.
STRINGi9606.ENSP00000252085.

Structurei

3D structure databases

ProteinModelPortaliO60330.
SMRiO60330.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 133Cadherin 1PROSITE-ProRule annotationAdd BLAST104
Domaini134 – 242Cadherin 2PROSITE-ProRule annotationAdd BLAST109
Domaini243 – 347Cadherin 3PROSITE-ProRule annotationAdd BLAST105
Domaini348 – 452Cadherin 4PROSITE-ProRule annotationAdd BLAST105
Domaini453 – 562Cadherin 5PROSITE-ProRule annotationAdd BLAST110
Domaini570 – 683Cadherin 6PROSITE-ProRule annotationAdd BLAST114

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129690.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiO60330.
KOiK16495.
OMAiIGELNHE.
OrthoDBiEOG091G024L.
PhylomeDBiO60330.
TreeFamiTF332299.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O60330-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIPARLHRDY KGLVLLGILL GTLWETGCTQ IRYSVPEELE KGSRVGDISR
60 70 80 90 100
DLGLEPRELA ERGVRIIPRG RTQLFALNPR SGSLVTAGRI DREELCMGAI
110 120 130 140 150
KCQLNLDILM EDKVKIYGVE VEVRDINDNA PYFRESELEI KISENAATEM
160 170 180 190 200
RFPLPHAWDP DIGKNSLQSY ELSPNTHFSL IVQNGADGSK YPELVLKRAL
210 220 230 240 250
DREEKAAHHL VLTASDGGDP VRTGTARIRV MVLDANDNAP AFAQPEYRAS
260 270 280 290 300
VPENLALGTQ LLVVNATDPD EGVNAEVRYS FRYVDDKAAQ VFKLDCNSGT
310 320 330 340 350
ISTIGELDHE ESGFYQMEVQ AMDNAGYSAR AKVLITVLDV NDNAPEVVLT
360 370 380 390 400
SLASSVPENS PRGTLIALLN VNDQDSEENG QVICFIQGNL PFKLEKSYGN
410 420 430 440 450
YYSLVTDIVL DREQVPSYNI TVTATDRGTP PLSTETHISL NVADTNDNPP
460 470 480 490 500
VFPQASYSAY IPENNPRGVS LVSVTAHDPD CEENAQITYS LAENTIQGAS
510 520 530 540 550
LSSYVSINSD TGVLYALSSF DYEQFRDLQV KVMARDNGHP PLSSNVSLSL
560 570 580 590 600
FVLDQNDNAP EILYPALPTD GSTGVELAPR SAEPGYLVTK VVAVDRDSGQ
610 620 630 640 650
NAWLSYRLLK ASEPGLFSVG LHTGEVRTAR ALLDRDALKQ SLVVAVQDHG
660 670 680 690 700
QPPLSATVTL TVAVADSIPQ VLADLGSLES PANSETSDLT LYLVVAVAAV
710 720 730 740 750
SCVFLAFVIL LLALRLRRWH KSRLLQASGG GLTGAPASHF VGVDGVQAFL
760 770 780 790 800
QTYSHEVSLT TDSRKSHLIF PQPNYADMLV SQESFEKSEP LLLSGDSVFS
810 820 830 840 850
KDSHGLIEQA PPNTDWRFSQ AQRPGTSGSQ NGDDTGTWPN NQFDTEMLQA
860 870 880 890 900
MILASASEAA DGSSTLGGGA GTMGLSARYG PQFTLQHVPD YRQNVYIPGS
910 920 930
NATLTNAAGK RDGKAPAGGN GNKKKSGKKE KK
Length:932
Mass (Da):100,955
Last modified:August 1, 1998 - v1
Checksum:i8BDA90084785D746
GO
Isoform 2 (identifier: O60330-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     809-820: QAPPNTDWRFSQ → VSLYQIFFLFFF
     821-932: Missing.

Show »
Length:820
Mass (Da):89,582
Checksum:i5ED08F61B9BA30FB
GO

Sequence cautioni

The sequence AAQ89305 differs from that shown. Probable cloning artifact.Curated
The sequence BAA25514 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti331A → P in BAA21135 (PubMed:9199196).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_008682809 – 820QAPPN…WRFSQ → VSLYQIFFLFFF in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_008683821 – 932Missing in isoform 2. 1 PublicationAdd BLAST112

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152321 mRNA. Translation: AAD43715.1.
AF152506 mRNA. Translation: AAD43767.1.
AB011160 mRNA. Translation: BAA25514.2. Different initiation.
AY358946 mRNA. Translation: AAQ89305.1. Sequence problems.
AB000897 mRNA. Translation: BAA21135.1.
CCDSiCCDS4260.1. [O60330-1]
CCDS75346.1. [O60330-2]
PIRiPC4299.
RefSeqiNP_003726.1. NM_003735.2. [O60330-1]
NP_115265.1. NM_032094.1. [O60330-2]
UniGeneiHs.368160.

Genome annotation databases

EnsembliENST00000252085; ENSP00000252085; ENSG00000253159. [O60330-1]
ENST00000613314; ENSP00000481438; ENSG00000253159. [O60330-2]
GeneIDi26025.
KEGGihsa:26025.
UCSCiuc003lkt.3. human. [O60330-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152321 mRNA. Translation: AAD43715.1.
AF152506 mRNA. Translation: AAD43767.1.
AB011160 mRNA. Translation: BAA25514.2. Different initiation.
AY358946 mRNA. Translation: AAQ89305.1. Sequence problems.
AB000897 mRNA. Translation: BAA21135.1.
CCDSiCCDS4260.1. [O60330-1]
CCDS75346.1. [O60330-2]
PIRiPC4299.
RefSeqiNP_003726.1. NM_003735.2. [O60330-1]
NP_115265.1. NM_032094.1. [O60330-2]
UniGeneiHs.368160.

3D structure databases

ProteinModelPortaliO60330.
SMRiO60330.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117494. 2 interactors.
STRINGi9606.ENSP00000252085.

PTM databases

iPTMnetiO60330.
PhosphoSitePlusiO60330.

Polymorphism and mutation databases

BioMutaiPCDHGA12.

Proteomic databases

EPDiO60330.
MaxQBiO60330.
PaxDbiO60330.
PeptideAtlasiO60330.
PRIDEiO60330.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252085; ENSP00000252085; ENSG00000253159. [O60330-1]
ENST00000613314; ENSP00000481438; ENSG00000253159. [O60330-2]
GeneIDi26025.
KEGGihsa:26025.
UCSCiuc003lkt.3. human. [O60330-1]

Organism-specific databases

CTDi26025.
GeneCardsiPCDHGA12.
HGNCiHGNC:8699. PCDHGA12.
HPAiHPA008755.
MIMi603059. gene.
604968. gene.
neXtProtiNX_O60330.
OpenTargetsiENSG00000253159.
PharmGKBiPA33047.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129690.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiO60330.
KOiK16495.
OMAiIGELNHE.
OrthoDBiEOG091G024L.
PhylomeDBiO60330.
TreeFamiTF332299.

Miscellaneous databases

GeneWikiiPCDHGA12.
GenomeRNAii26025.
PROiO60330.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000253159.
GenevisibleiO60330. HS.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCDGC_HUMAN
AccessioniPrimary (citable) accession number: O60330
Secondary accession number(s): O15100, Q6UW70, Q9Y5D7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: August 1, 1998
Last modified: November 30, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.