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O60330

- PCDGC_HUMAN

UniProt

O60330 - PCDGC_HUMAN

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Protein

Protocadherin gamma-A12

Gene
PCDHGA12, CDH21, FIB3, KIAA0588, UNQ371/PRO707
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. homophilic cell adhesion Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin gamma-A12
Short name:
PCDH-gamma-A12
Alternative name(s):
Cadherin-21
Fibroblast cadherin-3
Gene namesi
Synonyms:CDH21, FIB3, KIAA0588
ORF Names:UNQ371/PRO707
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:8699. PCDHGA12.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 692663Extracellular Reviewed predictionAdd
BLAST
Transmembranei693 – 71321Helical; Reviewed predictionAdd
BLAST
Topological domaini714 – 932219Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33047.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929 Reviewed predictionAdd
BLAST
Chaini30 – 932903Protocadherin gamma-A12PRO_0000003970Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi265 – 2651N-linked (GlcNAc...) Reviewed prediction
Glycosylationi419 – 4191N-linked (GlcNAc...) Reviewed prediction
Glycosylationi545 – 5451N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO60330.
PRIDEiO60330.

PTM databases

PhosphoSiteiO60330.

Expressioni

Gene expression databases

BgeeiO60330.
GenevestigatoriO60330.

Organism-specific databases

HPAiHPA008755.

Interactioni

Protein-protein interaction databases

BioGridi117494. 1 interaction.
STRINGi9606.ENSP00000252085.

Structurei

3D structure databases

ProteinModelPortaliO60330.
SMRiO60330. Positions 27-666.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 133104Cadherin 1Add
BLAST
Domaini134 – 242109Cadherin 2Add
BLAST
Domaini243 – 347105Cadherin 3Add
BLAST
Domaini348 – 452105Cadherin 4Add
BLAST
Domaini453 – 562110Cadherin 5Add
BLAST
Domaini570 – 683114Cadherin 6Add
BLAST

Sequence similaritiesi

Contains 6 cadherin domains.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG256872.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
KOiK16495.
OMAiREEKAIH.
OrthoDBiEOG7KSX80.
PhylomeDBiO60330.
TreeFamiTF332299.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O60330-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MIPARLHRDY KGLVLLGILL GTLWETGCTQ IRYSVPEELE KGSRVGDISR    50
DLGLEPRELA ERGVRIIPRG RTQLFALNPR SGSLVTAGRI DREELCMGAI 100
KCQLNLDILM EDKVKIYGVE VEVRDINDNA PYFRESELEI KISENAATEM 150
RFPLPHAWDP DIGKNSLQSY ELSPNTHFSL IVQNGADGSK YPELVLKRAL 200
DREEKAAHHL VLTASDGGDP VRTGTARIRV MVLDANDNAP AFAQPEYRAS 250
VPENLALGTQ LLVVNATDPD EGVNAEVRYS FRYVDDKAAQ VFKLDCNSGT 300
ISTIGELDHE ESGFYQMEVQ AMDNAGYSAR AKVLITVLDV NDNAPEVVLT 350
SLASSVPENS PRGTLIALLN VNDQDSEENG QVICFIQGNL PFKLEKSYGN 400
YYSLVTDIVL DREQVPSYNI TVTATDRGTP PLSTETHISL NVADTNDNPP 450
VFPQASYSAY IPENNPRGVS LVSVTAHDPD CEENAQITYS LAENTIQGAS 500
LSSYVSINSD TGVLYALSSF DYEQFRDLQV KVMARDNGHP PLSSNVSLSL 550
FVLDQNDNAP EILYPALPTD GSTGVELAPR SAEPGYLVTK VVAVDRDSGQ 600
NAWLSYRLLK ASEPGLFSVG LHTGEVRTAR ALLDRDALKQ SLVVAVQDHG 650
QPPLSATVTL TVAVADSIPQ VLADLGSLES PANSETSDLT LYLVVAVAAV 700
SCVFLAFVIL LLALRLRRWH KSRLLQASGG GLTGAPASHF VGVDGVQAFL 750
QTYSHEVSLT TDSRKSHLIF PQPNYADMLV SQESFEKSEP LLLSGDSVFS 800
KDSHGLIEQA PPNTDWRFSQ AQRPGTSGSQ NGDDTGTWPN NQFDTEMLQA 850
MILASASEAA DGSSTLGGGA GTMGLSARYG PQFTLQHVPD YRQNVYIPGS 900
NATLTNAAGK RDGKAPAGGN GNKKKSGKKE KK 932
Length:932
Mass (Da):100,955
Last modified:August 1, 1998 - v1
Checksum:i8BDA90084785D746
GO
Isoform 2 (identifier: O60330-2) [UniParc]FASTAAdd to Basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     809-820: QAPPNTDWRFSQ → VSLYQIFFLFFF
     821-932: Missing.

Show »
Length:820
Mass (Da):89,582
Checksum:i5ED08F61B9BA30FB
GO

Sequence cautioni

The sequence AAQ89305.1 differs from that shown. Reason: Probable cloning artifact.
The sequence BAA25514.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei809 – 82012QAPPN…WRFSQ → VSLYQIFFLFFF in isoform 2. VSP_008682Add
BLAST
Alternative sequencei821 – 932112Missing in isoform 2. VSP_008683Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti331 – 3311A → P in BAA21135. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF152321 mRNA. Translation: AAD43715.1.
AF152506 mRNA. Translation: AAD43767.1.
AB011160 mRNA. Translation: BAA25514.2. Different initiation.
AY358946 mRNA. Translation: AAQ89305.1. Sequence problems.
AB000897 mRNA. Translation: BAA21135.1.
CCDSiCCDS4260.1. [O60330-1]
PIRiPC4299.
RefSeqiNP_003726.1. NM_003735.2. [O60330-1]
NP_115265.1. NM_032094.1. [O60330-2]
UniGeneiHs.368160.

Genome annotation databases

EnsembliENST00000252085; ENSP00000252085; ENSG00000253159. [O60330-1]
GeneIDi26025.
KEGGihsa:26025.
UCSCiuc003lkt.2. human. [O60330-1]
uc011dba.2. human. [O60330-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF152321 mRNA. Translation: AAD43715.1 .
AF152506 mRNA. Translation: AAD43767.1 .
AB011160 mRNA. Translation: BAA25514.2 . Different initiation.
AY358946 mRNA. Translation: AAQ89305.1 . Sequence problems.
AB000897 mRNA. Translation: BAA21135.1 .
CCDSi CCDS4260.1. [O60330-1 ]
PIRi PC4299.
RefSeqi NP_003726.1. NM_003735.2. [O60330-1 ]
NP_115265.1. NM_032094.1. [O60330-2 ]
UniGenei Hs.368160.

3D structure databases

ProteinModelPortali O60330.
SMRi O60330. Positions 27-666.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117494. 1 interaction.
STRINGi 9606.ENSP00000252085.

PTM databases

PhosphoSitei O60330.

Proteomic databases

PaxDbi O60330.
PRIDEi O60330.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000252085 ; ENSP00000252085 ; ENSG00000253159 . [O60330-1 ]
GeneIDi 26025.
KEGGi hsa:26025.
UCSCi uc003lkt.2. human. [O60330-1 ]
uc011dba.2. human. [O60330-2 ]

Organism-specific databases

CTDi 26025.
GeneCardsi GC05P141298.
HGNCi HGNC:8699. PCDHGA12.
HPAi HPA008755.
MIMi 603059. gene.
604968. gene.
neXtProti NX_O60330.
PharmGKBi PA33047.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG256872.
HOGENOMi HOG000220892.
HOVERGENi HBG054878.
KOi K16495.
OMAi REEKAIH.
OrthoDBi EOG7KSX80.
PhylomeDBi O60330.
TreeFami TF332299.

Miscellaneous databases

GeneWikii PCDHGA12.
GenomeRNAii 26025.
NextBioi 47808.
PROi O60330.
SOURCEi Search...

Gene expression databases

Bgeei O60330.
Genevestigatori O60330.

Family and domain databases

Gene3Di 2.60.40.60. 6 hits.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view ]
Pfami PF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
SMARTi SM00112. CA. 6 hits.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 6 hits.
PROSITEi PS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A striking organization of a large family of human neural cadherin-like cell adhesion genes."
    Wu Q., Maniatis T.
    Cell 97:779-790(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.
  2. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-808.
  4. "Multiple cadherins are expressed in human fibroblasts."
    Matsuyoshi N., Imamura S.
    Biochem. Biophys. Res. Commun. 235:355-358(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 311-444.

Entry informationi

Entry nameiPCDGC_HUMAN
AccessioniPrimary (citable) accession number: O60330
Secondary accession number(s): O15100, Q6UW70, Q9Y5D7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: August 1, 1998
Last modified: July 9, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi