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O60330 (PCDGC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protocadherin gamma-A12

Short name=PCDH-gamma-A12
Alternative name(s):
Cadherin-21
Fibroblast cadherin-3
Gene names
Name:PCDHGA12
Synonyms:CDH21, FIB3, KIAA0588
ORF Names:UNQ371/PRO707
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length932 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

Subcellular location

Cell membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Contains 6 cadherin domains.

Sequence caution

The sequence AAQ89305.1 differs from that shown. Reason: Probable cloning artifact.

The sequence BAA25514.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentCell membrane
Membrane
   Coding sequence diversityAlternative splicing
   DomainRepeat
Signal
Transmembrane
Transmembrane helix
   LigandCalcium
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processhomophilic cell adhesion

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O60330-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O60330-2)

Also known as: Short;

The sequence of this isoform differs from the canonical sequence as follows:
     809-820: QAPPNTDWRFSQ → VSLYQIFFLFFF
     821-932: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Chain30 – 932903Protocadherin gamma-A12
PRO_0000003970

Regions

Topological domain30 – 692663Extracellular Potential
Transmembrane693 – 71321Helical; Potential
Topological domain714 – 932219Cytoplasmic Potential
Domain30 – 133104Cadherin 1
Domain134 – 242109Cadherin 2
Domain243 – 347105Cadherin 3
Domain348 – 452105Cadherin 4
Domain453 – 562110Cadherin 5
Domain570 – 683114Cadherin 6

Amino acid modifications

Glycosylation2651N-linked (GlcNAc...) Potential
Glycosylation4191N-linked (GlcNAc...) Potential
Glycosylation5451N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence809 – 82012QAPPN…WRFSQ → VSLYQIFFLFFF in isoform 2.
VSP_008682
Alternative sequence821 – 932112Missing in isoform 2.
VSP_008683

Experimental info

Sequence conflict3311A → P in BAA21135. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 8BDA90084785D746

FASTA932100,955
        10         20         30         40         50         60 
MIPARLHRDY KGLVLLGILL GTLWETGCTQ IRYSVPEELE KGSRVGDISR DLGLEPRELA 

        70         80         90        100        110        120 
ERGVRIIPRG RTQLFALNPR SGSLVTAGRI DREELCMGAI KCQLNLDILM EDKVKIYGVE 

       130        140        150        160        170        180 
VEVRDINDNA PYFRESELEI KISENAATEM RFPLPHAWDP DIGKNSLQSY ELSPNTHFSL 

       190        200        210        220        230        240 
IVQNGADGSK YPELVLKRAL DREEKAAHHL VLTASDGGDP VRTGTARIRV MVLDANDNAP 

       250        260        270        280        290        300 
AFAQPEYRAS VPENLALGTQ LLVVNATDPD EGVNAEVRYS FRYVDDKAAQ VFKLDCNSGT 

       310        320        330        340        350        360 
ISTIGELDHE ESGFYQMEVQ AMDNAGYSAR AKVLITVLDV NDNAPEVVLT SLASSVPENS 

       370        380        390        400        410        420 
PRGTLIALLN VNDQDSEENG QVICFIQGNL PFKLEKSYGN YYSLVTDIVL DREQVPSYNI 

       430        440        450        460        470        480 
TVTATDRGTP PLSTETHISL NVADTNDNPP VFPQASYSAY IPENNPRGVS LVSVTAHDPD 

       490        500        510        520        530        540 
CEENAQITYS LAENTIQGAS LSSYVSINSD TGVLYALSSF DYEQFRDLQV KVMARDNGHP 

       550        560        570        580        590        600 
PLSSNVSLSL FVLDQNDNAP EILYPALPTD GSTGVELAPR SAEPGYLVTK VVAVDRDSGQ 

       610        620        630        640        650        660 
NAWLSYRLLK ASEPGLFSVG LHTGEVRTAR ALLDRDALKQ SLVVAVQDHG QPPLSATVTL 

       670        680        690        700        710        720 
TVAVADSIPQ VLADLGSLES PANSETSDLT LYLVVAVAAV SCVFLAFVIL LLALRLRRWH 

       730        740        750        760        770        780 
KSRLLQASGG GLTGAPASHF VGVDGVQAFL QTYSHEVSLT TDSRKSHLIF PQPNYADMLV 

       790        800        810        820        830        840 
SQESFEKSEP LLLSGDSVFS KDSHGLIEQA PPNTDWRFSQ AQRPGTSGSQ NGDDTGTWPN 

       850        860        870        880        890        900 
NQFDTEMLQA MILASASEAA DGSSTLGGGA GTMGLSARYG PQFTLQHVPD YRQNVYIPGS 

       910        920        930 
NATLTNAAGK RDGKAPAGGN GNKKKSGKKE KK 

« Hide

Isoform 2 (Short) [UniParc].

Checksum: 5ED08F61B9BA30FB
Show »

FASTA82089,582

References

« Hide 'large scale' references
[1]"A striking organization of a large family of human neural cadherin-like cell adhesion genes."
Wu Q., Maniatis T.
Cell 97:779-790(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
Tissue: Brain.
[2]"Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[3]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-808.
[4]"Multiple cadherins are expressed in human fibroblasts."
Matsuyoshi N., Imamura S.
Biochem. Biophys. Res. Commun. 235:355-358(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 311-444.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF152321 mRNA. Translation: AAD43715.1.
AF152506 mRNA. Translation: AAD43767.1.
AB011160 mRNA. Translation: BAA25514.2. Different initiation.
AY358946 mRNA. Translation: AAQ89305.1. Sequence problems.
AB000897 mRNA. Translation: BAA21135.1.
CCDSCCDS4260.1. [O60330-1]
PIRPC4299.
RefSeqNP_003726.1. NM_003735.2. [O60330-1]
NP_115265.1. NM_032094.1. [O60330-2]
UniGeneHs.368160.

3D structure databases

ProteinModelPortalO60330.
SMRO60330. Positions 27-666.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117494. 1 interaction.
STRING9606.ENSP00000252085.

PTM databases

PhosphoSiteO60330.

Proteomic databases

PaxDbO60330.
PRIDEO60330.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000252085; ENSP00000252085; ENSG00000253159. [O60330-1]
GeneID26025.
KEGGhsa:26025.
UCSCuc003lkt.2. human. [O60330-1]
uc011dba.2. human. [O60330-2]

Organism-specific databases

CTD26025.
GeneCardsGC05P141298.
HGNCHGNC:8699. PCDHGA12.
HPAHPA008755.
MIM603059. gene.
604968. gene.
neXtProtNX_O60330.
PharmGKBPA33047.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG256872.
HOGENOMHOG000220892.
HOVERGENHBG054878.
KOK16495.
OMAREEKAIH.
OrthoDBEOG7KSX80.
PhylomeDBO60330.
TreeFamTF332299.

Gene expression databases

BgeeO60330.
GenevestigatorO60330.

Family and domain databases

Gene3D2.60.40.60. 6 hits.
InterProIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view]
PRINTSPR00205. CADHERIN.
SMARTSM00112. CA. 6 hits.
[Graphical view]
SUPFAMSSF49313. SSF49313. 6 hits.
PROSITEPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiPCDHGA12.
GenomeRNAi26025.
NextBio47808.
PROO60330.
SOURCESearch...

Entry information

Entry namePCDGC_HUMAN
AccessionPrimary (citable) accession number: O60330
Secondary accession number(s): O15100, Q6UW70, Q9Y5D7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: August 1, 1998
Last modified: July 9, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM