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O60318

- GANP_HUMAN

UniProt

O60318 - GANP_HUMAN

Protein

Germinal-center associated nuclear protein

Gene

MCM3AP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 2 (30 May 2000)
      Previous versions | rss
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    Functioni

    Isoform GANP: Essential for the generation of high-affinity B-cells against T-cell-dependent antigens by affecting somatic hypermutation at the IgV-regions. May have stimulation-dependent DNA primase activity that would generate extra RNA primers in very rapidely proliferating cells and would support clonal expansion of differentiating B-cells By similarity. Involved in the nuclear export of poly(A)-containing mRNAs by acting as a scaffold for the TREX-2 complex. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.By similarity1 Publication
    Isoform MCM3AP: Acetyltransferase targeting MCM3. Inhibits initiation of DNA replication, but not elongation.1 Publication

    GO - Molecular functioni

    1. DNA binding Source: ProtInc
    2. transferase activity, transferring acyl groups Source: UniProtKB-KW

    GO - Biological processi

    1. DNA replication Source: ProtInc
    2. immune system process Source: UniProtKB-KW
    3. mRNA transport Source: UniProtKB-KW
    4. protein import into nucleus Source: ProtInc

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Immunity, mRNA transport, Protein transport, Translocation, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Germinal-center associated nuclear protein
    Short name:
    GANP
    Alternative name(s):
    80 kDa MCM3-associated protein
    MCM3 acetylating protein (EC:2.3.1.-)
    Short name:
    MCM3AP
    MCM3 acetyltransferase
    Gene namesi
    Name:MCM3AP
    Synonyms:GANP, KIAA0572, MAP80
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 21

    Organism-specific databases

    HGNCiHGNC:6946. MCM3AP.

    Subcellular locationi

    Isoform GANP : Cytoplasm. Nucleus envelope. Nucleusnuclear pore complex
    Note: In B-cells nuclear import depends on interaction with AICDA/AID, and GANP is selectively targeted to the IgV-region gene.By similarity
    Isoform MCM3AP : Cytoplasm 1 Publication. Nucleusnucleoplasm 1 Publication
    Note: Binding to MCM3 is required for nuclear import, associates with chromatin.

    GO - Cellular componenti

    1. cytosol Source: UniProtKB
    2. nuclear pore Source: UniProtKB-SubCell
    3. nucleoplasm Source: UniProtKB-SubCell
    4. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nuclear pore complex, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi1730 – 17334HGAG → AAAA: Severely decreased MCM3 acetylating activity. 1 Publication

    Organism-specific databases

    PharmGKBiPA30692.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 19801980Germinal-center associated nuclear proteinPRO_0000096284Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei489 – 4891N6-acetyllysineBy similarity
    Modified residuei490 – 4901N6-acetyllysineBy similarity
    Modified residuei508 – 5081PhosphoserineBy similarity
    Modified residuei538 – 5381Phosphoserine3 Publications

    Post-translational modificationi

    Phosphorylation at Ser-508 by CDKs is required for DNA primase activity.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiO60318.
    PaxDbiO60318.
    PeptideAtlasiO60318.
    PRIDEiO60318.

    PTM databases

    PhosphoSiteiO60318.

    Expressioni

    Gene expression databases

    ArrayExpressiO60318.
    BgeeiO60318.
    CleanExiHS_MCM3AP.
    GenevestigatoriO60318.

    Organism-specific databases

    HPAiHPA021527.

    Interactioni

    Subunit structurei

    Interacts with AICDA/AID By similarity. Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least GANP, two copies of ENY2, PCID2, DSS1, and either centrin CETN2 or CETN3. Isoform MCM3AP interacts with MCM3. Interacts with NXF1 (By via FG-repeats).By similarity3 Publications

    Protein-protein interaction databases

    BioGridi114406. 23 interactions.
    DIPiDIP-31696N.
    IntActiO60318. 26 interactions.
    MINTiMINT-1180375.
    STRINGi9606.ENSP00000291688.

    Structurei

    Secondary structure

    1
    1980
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi1168 – 123265

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4DHXX-ray2.10A/D1163-1235[»]
    ProteinModelPortaliO60318.
    SMRiO60318. Positions 688-969, 1163-1234.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni33 – 340308FG-repeatsAdd
    BLAST
    Regioni421 – 557137DNA primaseAdd
    BLAST
    Regioni636 – 990355SAC3 homologyAdd
    BLAST
    Regioni1162 – 125695CIDAdd
    BLAST
    Regioni1658 – 1790133AcetyltransferaseAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili1133 – 117038Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SAC3 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG5079.
    HOGENOMiHOG000113500.
    HOVERGENiHBG052431.
    InParanoidiO60318.
    OMAiAHQMKVQ.
    OrthoDBiEOG78D7JB.
    PhylomeDBiO60318.
    TreeFamiTF105948.

    Family and domain databases

    InterProiIPR005062. SAC3/GANP/Nin1/mts3/eIF-3-p25.
    [Graphical view]
    PfamiPF03399. SAC3_GANP. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative promoter usage. Align

    Isoform GANP (identifier: O60318-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNPTNPFSGQ QPSAFSASSS NVGTLPSKPP FRFGQPSLFG QNSTLSGKSS     50
    GFSQVSSFPA SSGVSHSSSV QTLGFTQTSS VGPFSGLEHT STFVATSGPS 100
    SSSVLGNTGF SFKSPTSVGA FPSTSAFGQE AGEIVNSGFG KTEFSFKPLE 150
    NAVFKPILGA ESEPEKTQSQ IASGFFTFSH PISSAPGGLA PFSFPQVTSS 200
    SATTSNFTFS KPVSSNNSLS AFTPALSNQN VEEEKRGPKS IFGSSNNSFS 250
    SFPVSSAVLG EPFQASKAGV RQGCEEAVSQ VEPLPSLMKG LKRKEDQDRS 300
    PRRHGHEPAE DSDPLSRGDH PPDKRPVRLN RPRGGTLFGR TIQDVFKSNK 350
    EVGRLGNKEA KKETGFVESA ESDHMAIPGG NQSVLAPSRI PGVNKEEETE 400
    SREKKEDSLR GTPARQSNRS ESTDSLGGLS PSEVTAIQCK NIPDYLNDRT 450
    ILENHFGKIA KVQRIFTRRS KKLAVVHFFD HASAALARKK GKSLHKDMAI 500
    FWHRKKISPN KKPFSLKEKK PGDGEVSPST EDAPFQHSPL GKAAGRTGAS 550
    SLLNKSSPVK KPSLLKAHQF EGDSFDSASE GSEGLGPCVL SLSTLIGTVA 600
    ETSKEKYRLL DQRDRIMRQA RVKRTDLDKA RTFVGTCLDM CPEKERYMRE 650
    TRSQLSVFEV VPGTDQVDHA AAVKEYSRSS ADQEEPLPHE LRPLPVLSRT 700
    MDYLVTQIMD QKEGSLRDWY DFVWNRTRGI RKDITQQHLC DPLTVSLIEK 750
    CTRFHIHCAH FMCEEPMSSF DAKINNENMT KCLQSLKEMY QDLRNKGVFC 800
    ASEAEFQGYN VLLSLNKGDI LREVQQFHPA VRNSSEVKFA VQAFAALNSN 850
    NFVRFFKLVQ SASYLNACLL HCYFSQIRKD ALRALNFAYT VSTQRSTIFP 900
    LDGVVRMLLF RDCEEATDFL TCHGLTVSDG CVELNRSAFL EPEGLSKTRK 950
    SVFITRKLTV SVGEIVNGGP LPPVPRHTPV CSFNSQNKYI GESLAAELPV 1000
    STQRPGSDTV GGGRGEECGV EPDAPLSSLP QSLPAPAPSP VPLPPVLALT 1050
    PSVAPSLFQL SVQPEPPPPE PVPMYSDEDL AQVVDELIQE ALQRDCEEVG 1100
    SAGAAYAAAA LGVSNAAMED LLTAATTGIL RHIAAEEVSK ERERREQERQ 1150
    RAEEERLKQE RELVLSELSQ GLAVELMERV MMEFVRETCS QELKNAVETD 1200
    QRVRVARCCE DVCAHLVDLF LVEEIFQTAK ETLQELQCFC KYLQRWREAV 1250
    TARKKLRRQM RAFPAAPCCV DVSDRLRALA PSAECPIAEE NLARGLLDLG 1300
    HAGRLGISCT RLRRLRNKTA HQMKVQHFYQ QLLSDVAWAS LDLPSLVAEH 1350
    LPGRQEHVFW KLVLVLPDVE EQSPESCGRI LANWLKVKFM GDEGSVDDTS 1400
    SDAGGIQTLS LFNSLSSKGD QMISVNVCIK VAHGALSDGA IDAVETQKDL 1450
    LGASGLMLLL PPKMKSEDMA EEDVYWLSAL LQLKQLLQAK PFQPALPLVV 1500
    LVPSPGGDAV EKEVEDGLML QDLVSAKLIS DYTVTEIPDT INDLQGSTKV 1550
    LQAVQWLVSH CPHSLDLCCQ TLIQYVEDGI GHEFSGRFFH DRRERRLGGL 1600
    ASQEPGAIIE LFNSVLQFLA SVVSSEQLCD LSWPVTEFAE AGGSRLLPHL 1650
    HWNAPEHLAW LKQAVLGFQL PQMDLPPLGA PWLPVCSMVV QYASQIPSSR 1700
    QTQPVLQSQV ENLLHRTYCR WKSKSPSPVH GAGPSVMEIP WDDLIALCIN 1750
    HKLRDWTPPR LPVTSEALSE DGQICVYFFK NDLKKYDVPL SWEQARLQTQ 1800
    KELQLREGRL AIKPFHPSAN NFPIPLLHMH RNWKRSTECA QEGRIPSTED 1850
    LMRGASAEEL LAQCLSSSLL LEKEENKRFE DQLQQWLSED SGAFTDLTSL 1900
    PLYLPQTLVS LSHTIEPVMK TSVTTSPQSD MMREQLQLSE ATGTCLGERL 1950
    KHLERLIRSS REEEVASELH LSALLDMVDI 1980
    Length:1,980
    Mass (Da):218,405
    Last modified:May 30, 2000 - v2
    Checksum:i503D192686FC38A8
    GO
    Isoform MCM3AP (identifier: O60318-2) [UniParc]FASTAAdd to Basket

    Also known as: 80 kDa MCM3-associated protein

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1259: Missing.

    Note: Produced via an alternative promoter within an intron of GANP. MCM3AP promoter elements are poorly conserved in mice, suggesting that the regulation of MCM3AP may be human specific.

    Show »
    Length:721
    Mass (Da):80,292
    Checksum:i6D50E6EEBB6257C1
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti102 – 1021S → L.2 Publications
    Corresponds to variant rs9975588 [ dbSNP | Ensembl ].
    VAR_019240
    Natural varianti288 – 2881M → V.1 Publication
    Corresponds to variant rs17182545 [ dbSNP | Ensembl ].
    VAR_019241
    Natural varianti333 – 3331R → L.1 Publication
    Corresponds to variant rs17182552 [ dbSNP | Ensembl ].
    VAR_019242
    Natural varianti409 – 4091L → V in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_035472
    Natural varianti413 – 4131P → L.1 Publication
    Corresponds to variant rs17182566 [ dbSNP | Ensembl ].
    VAR_019243
    Natural varianti915 – 9151E → K Found in a patient with border-line to mild intellectual disability, progressive polyneuropathy and ptosis; unknown pathological significance. 1 Publication
    VAR_070560
    Natural varianti1051 – 10511P → L.1 Publication
    Corresponds to variant rs17182850 [ dbSNP | Ensembl ].
    VAR_019244
    Natural varianti1062 – 10621V → M.1 Publication
    Corresponds to variant rs17182857 [ dbSNP | Ensembl ].
    VAR_019245
    Natural varianti1314 – 13141R → W.1 Publication
    Corresponds to variant rs17176709 [ dbSNP | Ensembl ].
    VAR_019246
    Natural varianti1449 – 14491D → E.1 Publication
    Corresponds to variant rs17183220 [ dbSNP | Ensembl ].
    VAR_019247
    Natural varianti1576 – 15761V → I.2 Publications
    Corresponds to variant rs17183248 [ dbSNP | Ensembl ].
    VAR_019248
    Natural varianti1795 – 17951A → T.1 Publication
    Corresponds to variant rs17183290 [ dbSNP | Ensembl ].
    VAR_019249
    Natural varianti1831 – 18311R → C.
    Corresponds to variant rs2298697 [ dbSNP | Ensembl ].
    VAR_053973
    Natural varianti1870 – 18701L → R.1 Publication
    Corresponds to variant rs17176933 [ dbSNP | Ensembl ].
    VAR_019250
    Natural varianti1941 – 19411A → V.1 Publication
    Corresponds to variant rs17183403 [ dbSNP | Ensembl ].
    VAR_019251

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 12591259Missing in isoform MCM3AP. CuratedVSP_053438Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ010089 mRNA. Translation: CAB52687.1.
    AY590469 Genomic DNA. Translation: AAS89300.1.
    AP000471 Genomic DNA. No translation available.
    AP001469 Genomic DNA. No translation available.
    BC013285 mRNA. Translation: AAH13285.2.
    BC004497 mRNA. Translation: AAH04497.2.
    BC104958 mRNA. Translation: AAI04959.1.
    BC104960 mRNA. Translation: AAI04961.1.
    AB011144 mRNA. Translation: BAA25498.1.
    AB005543 mRNA. Translation: BAA25170.1.
    CCDSiCCDS13734.1. [O60318-1]
    PIRiT00339.
    RefSeqiNP_003897.2. NM_003906.4. [O60318-1]
    XP_005261260.1. XM_005261203.2. [O60318-1]
    XP_005261261.1. XM_005261204.2. [O60318-1]
    XP_005261262.1. XM_005261205.1. [O60318-1]
    XP_005261263.1. XM_005261206.2. [O60318-1]
    XP_006724127.1. XM_006724064.1. [O60318-1]
    UniGeneiHs.389037.
    Hs.592438.

    Genome annotation databases

    EnsembliENST00000291688; ENSP00000291688; ENSG00000160294. [O60318-1]
    ENST00000397708; ENSP00000380820; ENSG00000160294. [O60318-1]
    GeneIDi8888.
    KEGGihsa:8888.
    UCSCiuc002zir.1. human. [O60318-1]

    Keywords - Coding sequence diversityi

    Alternative promoter usage, Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ010089 mRNA. Translation: CAB52687.1 .
    AY590469 Genomic DNA. Translation: AAS89300.1 .
    AP000471 Genomic DNA. No translation available.
    AP001469 Genomic DNA. No translation available.
    BC013285 mRNA. Translation: AAH13285.2 .
    BC004497 mRNA. Translation: AAH04497.2 .
    BC104958 mRNA. Translation: AAI04959.1 .
    BC104960 mRNA. Translation: AAI04961.1 .
    AB011144 mRNA. Translation: BAA25498.1 .
    AB005543 mRNA. Translation: BAA25170.1 .
    CCDSi CCDS13734.1. [O60318-1 ]
    PIRi T00339.
    RefSeqi NP_003897.2. NM_003906.4. [O60318-1 ]
    XP_005261260.1. XM_005261203.2. [O60318-1 ]
    XP_005261261.1. XM_005261204.2. [O60318-1 ]
    XP_005261262.1. XM_005261205.1. [O60318-1 ]
    XP_005261263.1. XM_005261206.2. [O60318-1 ]
    XP_006724127.1. XM_006724064.1. [O60318-1 ]
    UniGenei Hs.389037.
    Hs.592438.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4DHX X-ray 2.10 A/D 1163-1235 [» ]
    ProteinModelPortali O60318.
    SMRi O60318. Positions 688-969, 1163-1234.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114406. 23 interactions.
    DIPi DIP-31696N.
    IntActi O60318. 26 interactions.
    MINTi MINT-1180375.
    STRINGi 9606.ENSP00000291688.

    PTM databases

    PhosphoSitei O60318.

    Proteomic databases

    MaxQBi O60318.
    PaxDbi O60318.
    PeptideAtlasi O60318.
    PRIDEi O60318.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000291688 ; ENSP00000291688 ; ENSG00000160294 . [O60318-1 ]
    ENST00000397708 ; ENSP00000380820 ; ENSG00000160294 . [O60318-1 ]
    GeneIDi 8888.
    KEGGi hsa:8888.
    UCSCi uc002zir.1. human. [O60318-1 ]

    Organism-specific databases

    CTDi 8888.
    GeneCardsi GC21M047655.
    H-InvDB HIX0016189.
    HGNCi HGNC:6946. MCM3AP.
    HPAi HPA021527.
    MIMi 603294. gene.
    neXtProti NX_O60318.
    PharmGKBi PA30692.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5079.
    HOGENOMi HOG000113500.
    HOVERGENi HBG052431.
    InParanoidi O60318.
    OMAi AHQMKVQ.
    OrthoDBi EOG78D7JB.
    PhylomeDBi O60318.
    TreeFami TF105948.

    Miscellaneous databases

    ChiTaRSi MCM3AP. human.
    GeneWikii MCM3AP.
    GenomeRNAii 8888.
    NextBioi 33379.
    PROi O60318.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O60318.
    Bgeei O60318.
    CleanExi HS_MCM3AP.
    Genevestigatori O60318.

    Family and domain databases

    InterProi IPR005062. SAC3/GANP/Nin1/mts3/eIF-3-p25.
    [Graphical view ]
    Pfami PF03399. SAC3_GANP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure, expression, and chromosomal localization of the human gene encoding a germinal center-associated nuclear protein (GANP) that associates with MCM3 involved in the initiation of DNA replication."
      Abe E., Kuwahara K., Yoshida M., Suzuki M., Terasaki H., Matsuo Y., Takahashi E., Sakaguchi N.
      Gene 255:219-227(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. NIEHS SNPs program
      Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS LEU-102; VAL-288; LEU-333; LEU-413; LEU-1051; MET-1062; TRP-1314; GLU-1449; ILE-1576; THR-1795; ARG-1870 AND VAL-1941.
    3. "The DNA sequence of human chromosome 21."
      Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
      , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
      Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-102.
      Tissue: Brain.
    5. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 109-1980.
      Tissue: Brain.
    6. "Identification of a novel MCM3-associated protein that facilitates MCM3 nuclear localization."
      Takei Y., Tsujimoto G.
      J. Biol. Chem. 273:22177-22180(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1260-1980.
    7. "MCM3AP, a novel acetyltransferase that acetylates replication protein MCM3."
      Takei Y., Swietlik M., Tanoue A., Tsujimoto G., Kouzarides T., Laskey R.
      EMBO Rep. 2:119-123(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION (ISOFORM MCM3AP), SUBCELLULAR LOCATION (ISOFORM MCM3AP), INTERACTION WITH MCM3, MUTAGENESIS OF 1730-HIS--GLY-1733.
    8. "The MCM3 acetylase MCM3AP inhibits initiation, but not elongation, of DNA replication via interaction with MCM3."
      Takei Y., Assenberg M., Tsujimoto G., Laskey R.
      J. Biol. Chem. 277:43121-43125(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION (ISOFORM MCM3AP).
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-538, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-538, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    12. Cited for: FUNCTION (ISOFORM GANP), SUBCELLULAR LOCATION, FG-REPEATS, INTERACTION WITH NXF1.
    13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-538, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. "MCM3AP is transcribed from a promoter within an intron of the overlapping gene for GANP."
      Wickramasinghe V.O., McMurtrie P.I., Marr J., Amagase Y., Main S., Mills A.D., Laskey R.A., Takei Y.
      J. Mol. Biol. 406:355-361(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE PROMOTER USAGE, SUBCELLULAR LOCATION.
    15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. "Functional and structural characterization of the mammalian TREX-2 complex that links transcription with nuclear messenger RNA export."
      Jani D., Lutz S., Hurt E., Laskey R.A., Stewart M., Wickramasinghe V.O.
      Nucleic Acids Res. 40:4562-4573(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 1163-1235 IN COMPLEX WITH ENY2, FUNCTION, SUBUNIT, IDENTIFICATION IN THE TREX-2 COMPLEX, SUBCELLULAR LOCATION.
    17. Cited for: VARIANTS [LARGE SCALE ANALYSIS] VAL-409 AND ILE-1576.
    18. Cited for: VARIANT LYS-915.

    Entry informationi

    Entry nameiGANP_HUMAN
    AccessioniPrimary (citable) accession number: O60318
    Secondary accession number(s): C9JL56
    , Q2M3C1, Q6PJP6, Q9BSY5, Q9UMT4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 122 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 21
      Human chromosome 21: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3