Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O60318 (GANP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Germinal-center associated nuclear protein

Short name=GANP
Alternative name(s):
80 kDa MCM3-associated protein
MCM3 acetylating protein
Short name=MCM3AP
EC=2.3.1.-
MCM3 acetyltransferase
Gene names
Name:MCM3AP
Synonyms:GANP, KIAA0572, MAP80
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1980 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Isoform GANP:Essential for the generation of high-affinity B-cells against T-cell-dependent antigens by affecting somatic hypermutation at the IgV-regions. May have stimulation-dependent DNA primase activity that would generate extra RNA primers in very rapidely proliferating cells and would support clonal expansion of differentiating B-cells By similarity. Involved in the nuclear export of poly(A)-containing mRNAs by acting as a scaffold for the TREX-2 complex. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Ref.7 Ref.8 Ref.12 Ref.16

Isoform MCM3AP:Acetyltransferase targeting MCM3. Inhibits initiation of DNA replication, but not elongation. Ref.7 Ref.8 Ref.12 Ref.16

Subunit structure

Interacts with AICDA/AID By similarity. Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least GANP, two copies of ENY2, PCID2, DSS1, and either centrin CETN2 or CETN3. Isoform MCM3AP interacts with MCM3. Interacts with NXF1 (By via FG-repeats). Ref.7 Ref.12 Ref.16

Subcellular location

Isoform GANP: Cytoplasm. Nucleus envelope. Nucleusnuclear pore complex. Note: In B-cells nuclear import depends on interaction with AICDA/AID, and GANP is selectively targeted to the IgV-region gene By similarity. Ref.7 Ref.12 Ref.14 Ref.16

Isoform MCM3AP: Cytoplasm. Nucleusnucleoplasm. Note: Binding to MCM3 is required for nuclear import, associates with chromatin. Ref.7 Ref.12 Ref.14 Ref.16

Post-translational modification

Phosphorylation at Ser-508 by CDKs is required for DNA primase activity By similarity.

Sequence similarities

Belongs to the SAC3 family.

Alternative products

This entry describes 2 isoforms produced by alternative promoter usage. [Align] [Select]
Isoform GANP (identifier: O60318-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform MCM3AP (identifier: O60318-2)

Also known as: 80 kDa MCM3-associated protein;

The sequence of this isoform differs from the canonical sequence as follows:
     1-1259: Missing.
Note: Produced via an alternative promoter within an intron of GANP. MCM3AP promoter elements are poorly conserved in mice, suggesting that the regulation of MCM3AP may be human specific.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 19801980Germinal-center associated nuclear protein
PRO_0000096284

Regions

Region33 – 340308FG-repeats
Region421 – 557137DNA primase
Region636 – 990355SAC3 homology
Region1162 – 125695CID
Region1658 – 1790133Acetyltransferase
Coiled coil1133 – 117038 Potential

Amino acid modifications

Modified residue4891N6-acetyllysine By similarity
Modified residue4901N6-acetyllysine By similarity
Modified residue5081Phosphoserine By similarity
Modified residue5381Phosphoserine Ref.9 Ref.11 Ref.13

Natural variations

Alternative sequence1 – 12591259Missing in isoform MCM3AP.
VSP_053438
Natural variant1021S → L. Ref.2 Ref.4
Corresponds to variant rs9975588 [ dbSNP | Ensembl ].
VAR_019240
Natural variant2881M → V. Ref.2
Corresponds to variant rs17182545 [ dbSNP | Ensembl ].
VAR_019241
Natural variant3331R → L. Ref.2
Corresponds to variant rs17182552 [ dbSNP | Ensembl ].
VAR_019242
Natural variant4091L → V in a colorectal cancer sample; somatic mutation. Ref.17
VAR_035472
Natural variant4131P → L. Ref.2
Corresponds to variant rs17182566 [ dbSNP | Ensembl ].
VAR_019243
Natural variant9151E → K Found in a patient with border-line to mild intellectual disability, progressive polyneuropathy and ptosis; unknown pathological significance. Ref.18
VAR_070560
Natural variant10511P → L. Ref.2
Corresponds to variant rs17182850 [ dbSNP | Ensembl ].
VAR_019244
Natural variant10621V → M. Ref.2
Corresponds to variant rs17182857 [ dbSNP | Ensembl ].
VAR_019245
Natural variant13141R → W. Ref.2
Corresponds to variant rs17176709 [ dbSNP | Ensembl ].
VAR_019246
Natural variant14491D → E. Ref.2
Corresponds to variant rs17183220 [ dbSNP | Ensembl ].
VAR_019247
Natural variant15761V → I. Ref.2 Ref.17
Corresponds to variant rs17183248 [ dbSNP | Ensembl ].
VAR_019248
Natural variant17951A → T. Ref.2
Corresponds to variant rs17183290 [ dbSNP | Ensembl ].
VAR_019249
Natural variant18311R → C.
Corresponds to variant rs2298697 [ dbSNP | Ensembl ].
VAR_053973
Natural variant18701L → R. Ref.2
Corresponds to variant rs17176933 [ dbSNP | Ensembl ].
VAR_019250
Natural variant19411A → V. Ref.2
Corresponds to variant rs17183403 [ dbSNP | Ensembl ].
VAR_019251

Experimental info

Mutagenesis1730 – 17334HGAG → AAAA: Severely decreased MCM3 acetylating activity. Ref.7

Secondary structure

... 1980
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform GANP [UniParc].

Last modified May 30, 2000. Version 2.
Checksum: 503D192686FC38A8

FASTA1,980218,405
        10         20         30         40         50         60 
MNPTNPFSGQ QPSAFSASSS NVGTLPSKPP FRFGQPSLFG QNSTLSGKSS GFSQVSSFPA 

        70         80         90        100        110        120 
SSGVSHSSSV QTLGFTQTSS VGPFSGLEHT STFVATSGPS SSSVLGNTGF SFKSPTSVGA 

       130        140        150        160        170        180 
FPSTSAFGQE AGEIVNSGFG KTEFSFKPLE NAVFKPILGA ESEPEKTQSQ IASGFFTFSH 

       190        200        210        220        230        240 
PISSAPGGLA PFSFPQVTSS SATTSNFTFS KPVSSNNSLS AFTPALSNQN VEEEKRGPKS 

       250        260        270        280        290        300 
IFGSSNNSFS SFPVSSAVLG EPFQASKAGV RQGCEEAVSQ VEPLPSLMKG LKRKEDQDRS 

       310        320        330        340        350        360 
PRRHGHEPAE DSDPLSRGDH PPDKRPVRLN RPRGGTLFGR TIQDVFKSNK EVGRLGNKEA 

       370        380        390        400        410        420 
KKETGFVESA ESDHMAIPGG NQSVLAPSRI PGVNKEEETE SREKKEDSLR GTPARQSNRS 

       430        440        450        460        470        480 
ESTDSLGGLS PSEVTAIQCK NIPDYLNDRT ILENHFGKIA KVQRIFTRRS KKLAVVHFFD 

       490        500        510        520        530        540 
HASAALARKK GKSLHKDMAI FWHRKKISPN KKPFSLKEKK PGDGEVSPST EDAPFQHSPL 

       550        560        570        580        590        600 
GKAAGRTGAS SLLNKSSPVK KPSLLKAHQF EGDSFDSASE GSEGLGPCVL SLSTLIGTVA 

       610        620        630        640        650        660 
ETSKEKYRLL DQRDRIMRQA RVKRTDLDKA RTFVGTCLDM CPEKERYMRE TRSQLSVFEV 

       670        680        690        700        710        720 
VPGTDQVDHA AAVKEYSRSS ADQEEPLPHE LRPLPVLSRT MDYLVTQIMD QKEGSLRDWY 

       730        740        750        760        770        780 
DFVWNRTRGI RKDITQQHLC DPLTVSLIEK CTRFHIHCAH FMCEEPMSSF DAKINNENMT 

       790        800        810        820        830        840 
KCLQSLKEMY QDLRNKGVFC ASEAEFQGYN VLLSLNKGDI LREVQQFHPA VRNSSEVKFA 

       850        860        870        880        890        900 
VQAFAALNSN NFVRFFKLVQ SASYLNACLL HCYFSQIRKD ALRALNFAYT VSTQRSTIFP 

       910        920        930        940        950        960 
LDGVVRMLLF RDCEEATDFL TCHGLTVSDG CVELNRSAFL EPEGLSKTRK SVFITRKLTV 

       970        980        990       1000       1010       1020 
SVGEIVNGGP LPPVPRHTPV CSFNSQNKYI GESLAAELPV STQRPGSDTV GGGRGEECGV 

      1030       1040       1050       1060       1070       1080 
EPDAPLSSLP QSLPAPAPSP VPLPPVLALT PSVAPSLFQL SVQPEPPPPE PVPMYSDEDL 

      1090       1100       1110       1120       1130       1140 
AQVVDELIQE ALQRDCEEVG SAGAAYAAAA LGVSNAAMED LLTAATTGIL RHIAAEEVSK 

      1150       1160       1170       1180       1190       1200 
ERERREQERQ RAEEERLKQE RELVLSELSQ GLAVELMERV MMEFVRETCS QELKNAVETD 

      1210       1220       1230       1240       1250       1260 
QRVRVARCCE DVCAHLVDLF LVEEIFQTAK ETLQELQCFC KYLQRWREAV TARKKLRRQM 

      1270       1280       1290       1300       1310       1320 
RAFPAAPCCV DVSDRLRALA PSAECPIAEE NLARGLLDLG HAGRLGISCT RLRRLRNKTA 

      1330       1340       1350       1360       1370       1380 
HQMKVQHFYQ QLLSDVAWAS LDLPSLVAEH LPGRQEHVFW KLVLVLPDVE EQSPESCGRI 

      1390       1400       1410       1420       1430       1440 
LANWLKVKFM GDEGSVDDTS SDAGGIQTLS LFNSLSSKGD QMISVNVCIK VAHGALSDGA 

      1450       1460       1470       1480       1490       1500 
IDAVETQKDL LGASGLMLLL PPKMKSEDMA EEDVYWLSAL LQLKQLLQAK PFQPALPLVV 

      1510       1520       1530       1540       1550       1560 
LVPSPGGDAV EKEVEDGLML QDLVSAKLIS DYTVTEIPDT INDLQGSTKV LQAVQWLVSH 

      1570       1580       1590       1600       1610       1620 
CPHSLDLCCQ TLIQYVEDGI GHEFSGRFFH DRRERRLGGL ASQEPGAIIE LFNSVLQFLA 

      1630       1640       1650       1660       1670       1680 
SVVSSEQLCD LSWPVTEFAE AGGSRLLPHL HWNAPEHLAW LKQAVLGFQL PQMDLPPLGA 

      1690       1700       1710       1720       1730       1740 
PWLPVCSMVV QYASQIPSSR QTQPVLQSQV ENLLHRTYCR WKSKSPSPVH GAGPSVMEIP 

      1750       1760       1770       1780       1790       1800 
WDDLIALCIN HKLRDWTPPR LPVTSEALSE DGQICVYFFK NDLKKYDVPL SWEQARLQTQ 

      1810       1820       1830       1840       1850       1860 
KELQLREGRL AIKPFHPSAN NFPIPLLHMH RNWKRSTECA QEGRIPSTED LMRGASAEEL 

      1870       1880       1890       1900       1910       1920 
LAQCLSSSLL LEKEENKRFE DQLQQWLSED SGAFTDLTSL PLYLPQTLVS LSHTIEPVMK 

      1930       1940       1950       1960       1970       1980 
TSVTTSPQSD MMREQLQLSE ATGTCLGERL KHLERLIRSS REEEVASELH LSALLDMVDI 

« Hide

Isoform MCM3AP (80 kDa MCM3-associated protein) [UniParc].

Checksum: 6D50E6EEBB6257C1
Show »

FASTA72180,292

References

« Hide 'large scale' references
[1]"Structure, expression, and chromosomal localization of the human gene encoding a germinal center-associated nuclear protein (GANP) that associates with MCM3 involved in the initiation of DNA replication."
Abe E., Kuwahara K., Yoshida M., Suzuki M., Terasaki H., Matsuo Y., Takahashi E., Sakaguchi N.
Gene 255:219-227(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]NIEHS SNPs program
Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS LEU-102; VAL-288; LEU-333; LEU-413; LEU-1051; MET-1062; TRP-1314; GLU-1449; ILE-1576; THR-1795; ARG-1870 AND VAL-1941.
[3]"The DNA sequence of human chromosome 21."
Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A. expand/collapse author list , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-102.
Tissue: Brain.
[5]"Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 109-1980.
Tissue: Brain.
[6]"Identification of a novel MCM3-associated protein that facilitates MCM3 nuclear localization."
Takei Y., Tsujimoto G.
J. Biol. Chem. 273:22177-22180(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1260-1980.
[7]"MCM3AP, a novel acetyltransferase that acetylates replication protein MCM3."
Takei Y., Swietlik M., Tanoue A., Tsujimoto G., Kouzarides T., Laskey R.
EMBO Rep. 2:119-123(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION (ISOFORM MCM3AP), SUBCELLULAR LOCATION (ISOFORM MCM3AP), INTERACTION WITH MCM3, MUTAGENESIS OF 1730-HIS--GLY-1733.
[8]"The MCM3 acetylase MCM3AP inhibits initiation, but not elongation, of DNA replication via interaction with MCM3."
Takei Y., Assenberg M., Tsujimoto G., Laskey R.
J. Biol. Chem. 277:43121-43125(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION (ISOFORM MCM3AP).
[9]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-538, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[10]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[11]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-538, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[12]"mRNA export from mammalian cell nuclei is dependent on GANP."
Wickramasinghe V.O., McMurtrie P.I., Mills A.D., Takei Y., Penrhyn-Lowe S., Amagase Y., Main S., Marr J., Stewart M., Laskey R.A.
Curr. Biol. 20:25-31(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION (ISOFORM GANP), SUBCELLULAR LOCATION, FG-REPEATS, INTERACTION WITH NXF1.
[13]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-538, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[14]"MCM3AP is transcribed from a promoter within an intron of the overlapping gene for GANP."
Wickramasinghe V.O., McMurtrie P.I., Marr J., Amagase Y., Main S., Mills A.D., Laskey R.A., Takei Y.
J. Mol. Biol. 406:355-361(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: ALTERNATIVE PROMOTER USAGE, SUBCELLULAR LOCATION.
[15]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[16]"Functional and structural characterization of the mammalian TREX-2 complex that links transcription with nuclear messenger RNA export."
Jani D., Lutz S., Hurt E., Laskey R.A., Stewart M., Wickramasinghe V.O.
Nucleic Acids Res. 40:4562-4573(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 1163-1235 IN COMPLEX WITH ENY2, FUNCTION, SUBUNIT, IDENTIFICATION IN THE TREX-2 COMPLEX, SUBCELLULAR LOCATION.
[17]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] VAL-409 AND ILE-1576.
[18]"Identification of pathogenic gene variants in small families with intellectually disabled siblings by exome sequencing."
Schuurs-Hoeijmakers J.H., Vulto-van Silfhout A.T., Vissers L.E., van de Vondervoort I.I., van Bon B.W., de Ligt J., Gilissen C., Hehir-Kwa J.Y., Neveling K., del Rosario M., Hira G., Reitano S., Vitello A., Failla P., Greco D., Fichera M., Galesi O., Kleefstra T. expand/collapse author list , Greally M.T., Ockeloen C.W., Willemsen M.H., Bongers E.M., Janssen I.M., Pfundt R., Veltman J.A., Romano C., Willemsen M.A., van Bokhoven H., Brunner H.G., de Vries B.B., de Brouwer A.P.
J. Med. Genet. 50:802-811(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT LYS-915.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ010089 mRNA. Translation: CAB52687.1.
AY590469 Genomic DNA. Translation: AAS89300.1.
AP000471 Genomic DNA. No translation available.
AP001469 Genomic DNA. No translation available.
BC013285 mRNA. Translation: AAH13285.2.
BC004497 mRNA. Translation: AAH04497.2.
BC104958 mRNA. Translation: AAI04959.1.
BC104960 mRNA. Translation: AAI04961.1.
AB011144 mRNA. Translation: BAA25498.1.
AB005543 mRNA. Translation: BAA25170.1.
PIRT00339.
RefSeqNP_003897.2. NM_003906.4.
XP_005261260.1. XM_005261203.2.
XP_005261261.1. XM_005261204.2.
XP_005261262.1. XM_005261205.1.
XP_005261263.1. XM_005261206.2.
UniGeneHs.389037.
Hs.592438.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4DHXX-ray2.10A/D1163-1235[»]
ProteinModelPortalO60318.
SMRO60318. Positions 688-969, 1163-1234.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114406. 23 interactions.
DIPDIP-31696N.
IntActO60318. 26 interactions.
MINTMINT-1180375.
STRING9606.ENSP00000291688.

PTM databases

PhosphoSiteO60318.

Proteomic databases

PaxDbO60318.
PeptideAtlasO60318.
PRIDEO60318.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000291688; ENSP00000291688; ENSG00000160294. [O60318-1]
ENST00000397708; ENSP00000380820; ENSG00000160294. [O60318-1]
GeneID8888.
KEGGhsa:8888.
UCSCuc002zir.1. human. [O60318-1]

Organism-specific databases

CTD8888.
GeneCardsGC21M047655.
H-InvDBHIX0016189.
HGNCHGNC:6946. MCM3AP.
HPAHPA021527.
MIM603294. gene.
neXtProtNX_O60318.
PharmGKBPA30692.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5079.
HOGENOMHOG000113500.
HOVERGENHBG052431.
InParanoidO60318.
OMAAHQMKVQ.
OrthoDBEOG78D7JB.
PhylomeDBO60318.
TreeFamTF105948.

Gene expression databases

ArrayExpressO60318.
BgeeO60318.
CleanExHS_MCM3AP.
GenevestigatorO60318.

Family and domain databases

InterProIPR005062. SAC3/GANP/Nin1/mts3/eIF-3-p25.
[Graphical view]
PfamPF03399. SAC3_GANP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSMCM3AP. human.
GeneWikiMCM3AP.
GenomeRNAi8888.
NextBio33379.
PROO60318.
SOURCESearch...

Entry information

Entry nameGANP_HUMAN
AccessionPrimary (citable) accession number: O60318
Secondary accession number(s): C9JL56 expand/collapse secondary AC list , Q2M3C1, Q6PJP6, Q9BSY5, Q9UMT4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: April 16, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 21

Human chromosome 21: entries, gene names and cross-references to MIM