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O60318

- GANP_HUMAN

UniProt

O60318 - GANP_HUMAN

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Protein

Germinal-center associated nuclear protein

Gene

MCM3AP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Isoform GANP: Essential for the generation of high-affinity B-cells against T-cell-dependent antigens by affecting somatic hypermutation at the IgV-regions. May have stimulation-dependent DNA primase activity that would generate extra RNA primers in very rapidely proliferating cells and would support clonal expansion of differentiating B-cells (By similarity). Involved in the nuclear export of poly(A)-containing mRNAs by acting as a scaffold for the TREX-2 complex. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.By similarity1 Publication
Isoform MCM3AP: Acetyltransferase targeting MCM3. Inhibits initiation of DNA replication, but not elongation.1 Publication

GO - Molecular functioni

  1. DNA binding Source: ProtInc
  2. transferase activity, transferring acyl groups Source: UniProtKB-KW

GO - Biological processi

  1. DNA replication Source: ProtInc
  2. immune system process Source: UniProtKB-KW
  3. mRNA transport Source: UniProtKB-KW
  4. protein import into nucleus Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Immunity, mRNA transport, Protein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Germinal-center associated nuclear protein
Short name:
GANP
Alternative name(s):
80 kDa MCM3-associated protein
MCM3 acetylating protein (EC:2.3.1.-)
Short name:
MCM3AP
MCM3 acetyltransferase
Gene namesi
Name:MCM3AP
Synonyms:GANP, KIAA0572, MAP80
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 21

Organism-specific databases

HGNCiHGNC:6946. MCM3AP.

Subcellular locationi

Isoform GANP : Cytoplasm. Nucleus envelope. Nucleusnuclear pore complex
Note: In B-cells nuclear import depends on interaction with AICDA/AID, and GANP is selectively targeted to the IgV-region gene.By similarity
Isoform MCM3AP : Cytoplasm 1 Publication. Nucleusnucleoplasm 1 Publication
Note: Binding to MCM3 is required for nuclear import, associates with chromatin.

GO - Cellular componenti

  1. cytosol Source: UniProtKB
  2. nuclear pore Source: UniProtKB-KW
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nuclear pore complex, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi1730 – 17334HGAG → AAAA: Severely decreased MCM3 acetylating activity. 1 Publication

Organism-specific databases

PharmGKBiPA30692.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19801980Germinal-center associated nuclear proteinPRO_0000096284Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei489 – 4891N6-acetyllysineBy similarity
Modified residuei490 – 4901N6-acetyllysineBy similarity
Modified residuei508 – 5081PhosphoserineBy similarity
Modified residuei538 – 5381Phosphoserine3 Publications

Post-translational modificationi

Phosphorylation at Ser-508 by CDKs is required for DNA primase activity.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO60318.
PaxDbiO60318.
PeptideAtlasiO60318.
PRIDEiO60318.

PTM databases

PhosphoSiteiO60318.

Expressioni

Gene expression databases

BgeeiO60318.
CleanExiHS_MCM3AP.
ExpressionAtlasiO60318. baseline and differential.
GenevestigatoriO60318.

Organism-specific databases

HPAiHPA021527.

Interactioni

Subunit structurei

Interacts with AICDA/AID (By similarity). Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least GANP, two copies of ENY2, PCID2, DSS1, and either centrin CETN2 or CETN3. Isoform MCM3AP interacts with MCM3. Interacts with NXF1 (By via FG-repeats).By similarity3 Publications

Protein-protein interaction databases

BioGridi114406. 25 interactions.
DIPiDIP-31696N.
IntActiO60318. 26 interactions.
MINTiMINT-1180375.
STRINGi9606.ENSP00000291688.

Structurei

Secondary structure

1
1980
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi1168 – 123265Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4DHXX-ray2.10A/D1163-1235[»]
ProteinModelPortaliO60318.
SMRiO60318. Positions 688-969, 1163-1234.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni33 – 340308FG-repeatsAdd
BLAST
Regioni421 – 557137DNA primaseAdd
BLAST
Regioni636 – 990355SAC3 homologyAdd
BLAST
Regioni1162 – 125695CIDAdd
BLAST
Regioni1658 – 1790133AcetyltransferaseAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1133 – 117038Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the SAC3 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5079.
GeneTreeiENSGT00530000063781.
HOGENOMiHOG000113500.
HOVERGENiHBG052431.
InParanoidiO60318.
OMAiAHQMKVQ.
OrthoDBiEOG78D7JB.
PhylomeDBiO60318.
TreeFamiTF105948.

Family and domain databases

InterProiIPR005062. SAC3/GANP/Nin1/mts3/eIF-3-p25.
[Graphical view]
PfamiPF03399. SAC3_GANP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative promoter usage. Align

Isoform GANP (identifier: O60318-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNPTNPFSGQ QPSAFSASSS NVGTLPSKPP FRFGQPSLFG QNSTLSGKSS
60 70 80 90 100
GFSQVSSFPA SSGVSHSSSV QTLGFTQTSS VGPFSGLEHT STFVATSGPS
110 120 130 140 150
SSSVLGNTGF SFKSPTSVGA FPSTSAFGQE AGEIVNSGFG KTEFSFKPLE
160 170 180 190 200
NAVFKPILGA ESEPEKTQSQ IASGFFTFSH PISSAPGGLA PFSFPQVTSS
210 220 230 240 250
SATTSNFTFS KPVSSNNSLS AFTPALSNQN VEEEKRGPKS IFGSSNNSFS
260 270 280 290 300
SFPVSSAVLG EPFQASKAGV RQGCEEAVSQ VEPLPSLMKG LKRKEDQDRS
310 320 330 340 350
PRRHGHEPAE DSDPLSRGDH PPDKRPVRLN RPRGGTLFGR TIQDVFKSNK
360 370 380 390 400
EVGRLGNKEA KKETGFVESA ESDHMAIPGG NQSVLAPSRI PGVNKEEETE
410 420 430 440 450
SREKKEDSLR GTPARQSNRS ESTDSLGGLS PSEVTAIQCK NIPDYLNDRT
460 470 480 490 500
ILENHFGKIA KVQRIFTRRS KKLAVVHFFD HASAALARKK GKSLHKDMAI
510 520 530 540 550
FWHRKKISPN KKPFSLKEKK PGDGEVSPST EDAPFQHSPL GKAAGRTGAS
560 570 580 590 600
SLLNKSSPVK KPSLLKAHQF EGDSFDSASE GSEGLGPCVL SLSTLIGTVA
610 620 630 640 650
ETSKEKYRLL DQRDRIMRQA RVKRTDLDKA RTFVGTCLDM CPEKERYMRE
660 670 680 690 700
TRSQLSVFEV VPGTDQVDHA AAVKEYSRSS ADQEEPLPHE LRPLPVLSRT
710 720 730 740 750
MDYLVTQIMD QKEGSLRDWY DFVWNRTRGI RKDITQQHLC DPLTVSLIEK
760 770 780 790 800
CTRFHIHCAH FMCEEPMSSF DAKINNENMT KCLQSLKEMY QDLRNKGVFC
810 820 830 840 850
ASEAEFQGYN VLLSLNKGDI LREVQQFHPA VRNSSEVKFA VQAFAALNSN
860 870 880 890 900
NFVRFFKLVQ SASYLNACLL HCYFSQIRKD ALRALNFAYT VSTQRSTIFP
910 920 930 940 950
LDGVVRMLLF RDCEEATDFL TCHGLTVSDG CVELNRSAFL EPEGLSKTRK
960 970 980 990 1000
SVFITRKLTV SVGEIVNGGP LPPVPRHTPV CSFNSQNKYI GESLAAELPV
1010 1020 1030 1040 1050
STQRPGSDTV GGGRGEECGV EPDAPLSSLP QSLPAPAPSP VPLPPVLALT
1060 1070 1080 1090 1100
PSVAPSLFQL SVQPEPPPPE PVPMYSDEDL AQVVDELIQE ALQRDCEEVG
1110 1120 1130 1140 1150
SAGAAYAAAA LGVSNAAMED LLTAATTGIL RHIAAEEVSK ERERREQERQ
1160 1170 1180 1190 1200
RAEEERLKQE RELVLSELSQ GLAVELMERV MMEFVRETCS QELKNAVETD
1210 1220 1230 1240 1250
QRVRVARCCE DVCAHLVDLF LVEEIFQTAK ETLQELQCFC KYLQRWREAV
1260 1270 1280 1290 1300
TARKKLRRQM RAFPAAPCCV DVSDRLRALA PSAECPIAEE NLARGLLDLG
1310 1320 1330 1340 1350
HAGRLGISCT RLRRLRNKTA HQMKVQHFYQ QLLSDVAWAS LDLPSLVAEH
1360 1370 1380 1390 1400
LPGRQEHVFW KLVLVLPDVE EQSPESCGRI LANWLKVKFM GDEGSVDDTS
1410 1420 1430 1440 1450
SDAGGIQTLS LFNSLSSKGD QMISVNVCIK VAHGALSDGA IDAVETQKDL
1460 1470 1480 1490 1500
LGASGLMLLL PPKMKSEDMA EEDVYWLSAL LQLKQLLQAK PFQPALPLVV
1510 1520 1530 1540 1550
LVPSPGGDAV EKEVEDGLML QDLVSAKLIS DYTVTEIPDT INDLQGSTKV
1560 1570 1580 1590 1600
LQAVQWLVSH CPHSLDLCCQ TLIQYVEDGI GHEFSGRFFH DRRERRLGGL
1610 1620 1630 1640 1650
ASQEPGAIIE LFNSVLQFLA SVVSSEQLCD LSWPVTEFAE AGGSRLLPHL
1660 1670 1680 1690 1700
HWNAPEHLAW LKQAVLGFQL PQMDLPPLGA PWLPVCSMVV QYASQIPSSR
1710 1720 1730 1740 1750
QTQPVLQSQV ENLLHRTYCR WKSKSPSPVH GAGPSVMEIP WDDLIALCIN
1760 1770 1780 1790 1800
HKLRDWTPPR LPVTSEALSE DGQICVYFFK NDLKKYDVPL SWEQARLQTQ
1810 1820 1830 1840 1850
KELQLREGRL AIKPFHPSAN NFPIPLLHMH RNWKRSTECA QEGRIPSTED
1860 1870 1880 1890 1900
LMRGASAEEL LAQCLSSSLL LEKEENKRFE DQLQQWLSED SGAFTDLTSL
1910 1920 1930 1940 1950
PLYLPQTLVS LSHTIEPVMK TSVTTSPQSD MMREQLQLSE ATGTCLGERL
1960 1970 1980
KHLERLIRSS REEEVASELH LSALLDMVDI
Length:1,980
Mass (Da):218,405
Last modified:May 30, 2000 - v2
Checksum:i503D192686FC38A8
GO
Isoform MCM3AP (identifier: O60318-2) [UniParc]FASTAAdd to Basket

Also known as: 80 kDa MCM3-associated protein

The sequence of this isoform differs from the canonical sequence as follows:
     1-1259: Missing.

Note: Produced via an alternative promoter within an intron of GANP. MCM3AP promoter elements are poorly conserved in mice, suggesting that the regulation of MCM3AP may be human specific.

Show »
Length:721
Mass (Da):80,292
Checksum:i6D50E6EEBB6257C1
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti102 – 1021S → L.2 Publications
Corresponds to variant rs9975588 [ dbSNP | Ensembl ].
VAR_019240
Natural varianti288 – 2881M → V.1 Publication
Corresponds to variant rs17182545 [ dbSNP | Ensembl ].
VAR_019241
Natural varianti333 – 3331R → L.1 Publication
Corresponds to variant rs17182552 [ dbSNP | Ensembl ].
VAR_019242
Natural varianti409 – 4091L → V in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035472
Natural varianti413 – 4131P → L.1 Publication
Corresponds to variant rs17182566 [ dbSNP | Ensembl ].
VAR_019243
Natural varianti915 – 9151E → K Found in a patient with border-line to mild intellectual disability, progressive polyneuropathy and ptosis; unknown pathological significance. 1 Publication
VAR_070560
Natural varianti1051 – 10511P → L.1 Publication
Corresponds to variant rs17182850 [ dbSNP | Ensembl ].
VAR_019244
Natural varianti1062 – 10621V → M.1 Publication
Corresponds to variant rs17182857 [ dbSNP | Ensembl ].
VAR_019245
Natural varianti1314 – 13141R → W.1 Publication
Corresponds to variant rs17176709 [ dbSNP | Ensembl ].
VAR_019246
Natural varianti1449 – 14491D → E.1 Publication
Corresponds to variant rs17183220 [ dbSNP | Ensembl ].
VAR_019247
Natural varianti1576 – 15761V → I.2 Publications
Corresponds to variant rs17183248 [ dbSNP | Ensembl ].
VAR_019248
Natural varianti1795 – 17951A → T.1 Publication
Corresponds to variant rs17183290 [ dbSNP | Ensembl ].
VAR_019249
Natural varianti1831 – 18311R → C.
Corresponds to variant rs2298697 [ dbSNP | Ensembl ].
VAR_053973
Natural varianti1870 – 18701L → R.1 Publication
Corresponds to variant rs17176933 [ dbSNP | Ensembl ].
VAR_019250
Natural varianti1941 – 19411A → V.1 Publication
Corresponds to variant rs17183403 [ dbSNP | Ensembl ].
VAR_019251

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 12591259Missing in isoform MCM3AP. CuratedVSP_053438Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010089 mRNA. Translation: CAB52687.1.
AY590469 Genomic DNA. Translation: AAS89300.1.
AP000471 Genomic DNA. No translation available.
AP001469 Genomic DNA. No translation available.
BC013285 mRNA. Translation: AAH13285.2.
BC004497 mRNA. Translation: AAH04497.2.
BC104958 mRNA. Translation: AAI04959.1.
BC104960 mRNA. Translation: AAI04961.1.
AB011144 mRNA. Translation: BAA25498.1.
AB005543 mRNA. Translation: BAA25170.1.
CCDSiCCDS13734.1. [O60318-1]
PIRiT00339.
RefSeqiNP_003897.2. NM_003906.4. [O60318-1]
XP_005261260.1. XM_005261203.2. [O60318-1]
XP_005261261.1. XM_005261204.2. [O60318-1]
XP_005261262.1. XM_005261205.1. [O60318-1]
XP_005261263.1. XM_005261206.2. [O60318-1]
XP_006724127.1. XM_006724064.1. [O60318-1]
UniGeneiHs.389037.
Hs.592438.

Genome annotation databases

EnsembliENST00000291688; ENSP00000291688; ENSG00000160294. [O60318-1]
ENST00000397708; ENSP00000380820; ENSG00000160294. [O60318-1]
GeneIDi8888.
KEGGihsa:8888.
UCSCiuc002zir.1. human. [O60318-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010089 mRNA. Translation: CAB52687.1 .
AY590469 Genomic DNA. Translation: AAS89300.1 .
AP000471 Genomic DNA. No translation available.
AP001469 Genomic DNA. No translation available.
BC013285 mRNA. Translation: AAH13285.2 .
BC004497 mRNA. Translation: AAH04497.2 .
BC104958 mRNA. Translation: AAI04959.1 .
BC104960 mRNA. Translation: AAI04961.1 .
AB011144 mRNA. Translation: BAA25498.1 .
AB005543 mRNA. Translation: BAA25170.1 .
CCDSi CCDS13734.1. [O60318-1 ]
PIRi T00339.
RefSeqi NP_003897.2. NM_003906.4. [O60318-1 ]
XP_005261260.1. XM_005261203.2. [O60318-1 ]
XP_005261261.1. XM_005261204.2. [O60318-1 ]
XP_005261262.1. XM_005261205.1. [O60318-1 ]
XP_005261263.1. XM_005261206.2. [O60318-1 ]
XP_006724127.1. XM_006724064.1. [O60318-1 ]
UniGenei Hs.389037.
Hs.592438.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4DHX X-ray 2.10 A/D 1163-1235 [» ]
ProteinModelPortali O60318.
SMRi O60318. Positions 688-969, 1163-1234.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114406. 25 interactions.
DIPi DIP-31696N.
IntActi O60318. 26 interactions.
MINTi MINT-1180375.
STRINGi 9606.ENSP00000291688.

PTM databases

PhosphoSitei O60318.

Proteomic databases

MaxQBi O60318.
PaxDbi O60318.
PeptideAtlasi O60318.
PRIDEi O60318.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000291688 ; ENSP00000291688 ; ENSG00000160294 . [O60318-1 ]
ENST00000397708 ; ENSP00000380820 ; ENSG00000160294 . [O60318-1 ]
GeneIDi 8888.
KEGGi hsa:8888.
UCSCi uc002zir.1. human. [O60318-1 ]

Organism-specific databases

CTDi 8888.
GeneCardsi GC21M047655.
H-InvDB HIX0016189.
HGNCi HGNC:6946. MCM3AP.
HPAi HPA021527.
MIMi 603294. gene.
neXtProti NX_O60318.
PharmGKBi PA30692.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5079.
GeneTreei ENSGT00530000063781.
HOGENOMi HOG000113500.
HOVERGENi HBG052431.
InParanoidi O60318.
OMAi AHQMKVQ.
OrthoDBi EOG78D7JB.
PhylomeDBi O60318.
TreeFami TF105948.

Miscellaneous databases

ChiTaRSi MCM3AP. human.
GeneWikii MCM3AP.
GenomeRNAii 8888.
NextBioi 33379.
PROi O60318.
SOURCEi Search...

Gene expression databases

Bgeei O60318.
CleanExi HS_MCM3AP.
ExpressionAtlasi O60318. baseline and differential.
Genevestigatori O60318.

Family and domain databases

InterProi IPR005062. SAC3/GANP/Nin1/mts3/eIF-3-p25.
[Graphical view ]
Pfami PF03399. SAC3_GANP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure, expression, and chromosomal localization of the human gene encoding a germinal center-associated nuclear protein (GANP) that associates with MCM3 involved in the initiation of DNA replication."
    Abe E., Kuwahara K., Yoshida M., Suzuki M., Terasaki H., Matsuo Y., Takahashi E., Sakaguchi N.
    Gene 255:219-227(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. NIEHS SNPs program
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS LEU-102; VAL-288; LEU-333; LEU-413; LEU-1051; MET-1062; TRP-1314; GLU-1449; ILE-1576; THR-1795; ARG-1870 AND VAL-1941.
  3. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-102.
    Tissue: Brain.
  5. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 109-1980.
    Tissue: Brain.
  6. "Identification of a novel MCM3-associated protein that facilitates MCM3 nuclear localization."
    Takei Y., Tsujimoto G.
    J. Biol. Chem. 273:22177-22180(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1260-1980.
  7. "MCM3AP, a novel acetyltransferase that acetylates replication protein MCM3."
    Takei Y., Swietlik M., Tanoue A., Tsujimoto G., Kouzarides T., Laskey R.
    EMBO Rep. 2:119-123(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION (ISOFORM MCM3AP), SUBCELLULAR LOCATION (ISOFORM MCM3AP), INTERACTION WITH MCM3, MUTAGENESIS OF 1730-HIS--GLY-1733.
  8. "The MCM3 acetylase MCM3AP inhibits initiation, but not elongation, of DNA replication via interaction with MCM3."
    Takei Y., Assenberg M., Tsujimoto G., Laskey R.
    J. Biol. Chem. 277:43121-43125(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION (ISOFORM MCM3AP).
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-538, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-538, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  12. Cited for: FUNCTION (ISOFORM GANP), SUBCELLULAR LOCATION, FG-REPEATS, INTERACTION WITH NXF1.
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-538, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. "MCM3AP is transcribed from a promoter within an intron of the overlapping gene for GANP."
    Wickramasinghe V.O., McMurtrie P.I., Marr J., Amagase Y., Main S., Mills A.D., Laskey R.A., Takei Y.
    J. Mol. Biol. 406:355-361(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE PROMOTER USAGE, SUBCELLULAR LOCATION.
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "Functional and structural characterization of the mammalian TREX-2 complex that links transcription with nuclear messenger RNA export."
    Jani D., Lutz S., Hurt E., Laskey R.A., Stewart M., Wickramasinghe V.O.
    Nucleic Acids Res. 40:4562-4573(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 1163-1235 IN COMPLEX WITH ENY2, FUNCTION, SUBUNIT, IDENTIFICATION IN THE TREX-2 COMPLEX, SUBCELLULAR LOCATION.
  17. Cited for: VARIANTS [LARGE SCALE ANALYSIS] VAL-409 AND ILE-1576.
  18. Cited for: VARIANT LYS-915.

Entry informationi

Entry nameiGANP_HUMAN
AccessioniPrimary (citable) accession number: O60318
Secondary accession number(s): C9JL56
, Q2M3C1, Q6PJP6, Q9BSY5, Q9UMT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: November 26, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3