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O60315 (ZEB2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 151. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger E-box-binding homeobox 2
Alternative name(s):
Smad-interacting protein 1
Short name=SMADIP1
Zinc finger homeobox protein 1b
Gene names
Name:ZEB2
Synonyms:KIAA0569, SIP1, ZFHX1B, ZFX1B
ORF Names:HRIHFB2411
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1214 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters. Represses transcription of E-cadherin. Ref.8

Subunit structure

Binds activated SMAD1, activated SMAD2 and activated SMAD3; binding with SMAD4 is not detected By similarity. Interacts with CBX4 and CTBP1. Ref.8

Subcellular location

Nucleus Ref.7 Ref.8.

Post-translational modification

Sumoylation on Lys-391 and Lys-866 is promoted by the E3 SUMO-protein ligase CBX4, and impairs interaction with CTBP1 and transcription repression activity. Ref.8

Involvement in disease

Mowat-Wilson syndrome (MOWS) [MIM:235730]: A complex developmental disorder characterized by mental retardation, delayed motor development, epilepsy, microcephaly and a wide spectrum of clinically heterogeneous features suggestive of neurocristopathies at the cephalic, cardiac, and vagal levels. Affected patients show an easily recognizable facial appearance with deep set eyes and hypertelorism, medially divergent, broad eyebrows, prominent columella, pointed chin and uplifted, notched ear lobes. Some patients manifest Hirschsprung disease.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.1 Ref.11 Ref.12 Ref.13

Sequence similarities

Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.

Contains 7 C2H2-type zinc fingers.

Contains 1 homeobox DNA-binding domain.

Sequence caution

The sequence BAA25495.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   DiseaseDisease mutation
Epilepsy
Hirschsprung disease
Mental retardation
   DomainHomeobox
Repeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Molecular functionRepressor
   PTMAcetylation
Isopeptide bond
Ubl conjugation
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell proliferation in forebrain

Inferred from electronic annotation. Source: Ensembl

hippocampus development

Inferred from electronic annotation. Source: Ensembl

nervous system development

Non-traceable author statement Ref.2. Source: UniProtKB

neural crest cell migration

Inferred from electronic annotation. Source: Ensembl

neural tube closure

Inferred from electronic annotation. Source: Ensembl

positive regulation of JUN kinase activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of Wnt signaling pathway

Inferred from electronic annotation. Source: Ensembl

somitogenesis

Inferred from electronic annotation. Source: Ensembl

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphatase regulator activity

Non-traceable author statement PubMed 11477103. Source: UniProtKB

sequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O60315-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O60315-2)

The sequence of this isoform differs from the canonical sequence as follows:
     111-134: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12141214Zinc finger E-box-binding homeobox 2
PRO_0000047236

Regions

Zinc finger211 – 23424C2H2-type 1
Zinc finger241 – 26323C2H2-type 2
Zinc finger282 – 30423C2H2-type 3
Zinc finger310 – 33425C2H2-type 4; atypical
DNA binding644 – 70360Homeobox; atypical
Zinc finger999 – 102123C2H2-type 5
Zinc finger1027 – 104923C2H2-type 6
Zinc finger1055 – 107622C2H2-type 7; atypical
Region437 – 48751SMAD-MH2 binding domain By similarity
Compositional bias1084 – 1214131Glu-rich (acidic)

Amino acid modifications

Modified residue3771N6-acetyllysine Ref.9
Cross-link391Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) Ref.8
Cross-link866Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) Ref.8

Natural variations

Alternative sequence111 – 13424Missing in isoform 2.
VSP_044797
Natural variant991Missing in MOWS. Ref.11
VAR_027016
Natural variant9531R → G in MOWS. Ref.12
VAR_027017
Natural variant9831D → N in a colorectal cancer sample; somatic mutation. Ref.14
VAR_035563
Natural variant11191Q → R in MOWS. Ref.13
VAR_027018

Experimental info

Sequence conflict11551D → G in BAH11928. Ref.4

Secondary structure

....... 1214
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: B578FD91339C3FDD

FASTA1,214136,447
        10         20         30         40         50         60 
MKQPIMADGP RCKRRKQANP RRKNVVNYDN VVDTGSETDE EDKLHIAEDD GIANPLDQET 

        70         80         90        100        110        120 
SPASVPNHES SPHVSQALLP REEEEDEIRE GGVEHPWHNN EILQASVDGP EEMKEDYDTM 

       130        140        150        160        170        180 
GPEATIQTAI NNGTVKNANC TSDFEEYFAK RKLEERDGHA VSIEEYLQRS DTAIIYPEAP 

       190        200        210        220        230        240 
EELSRLGTPE ANGQEENDLP PGTPDAFAQL LTCPYCDRGY KRLTSLKEHI KYRHEKNEEN 

       250        260        270        280        290        300 
FSCPLCSYTF AYRTQLERHM VTHKPGTDQH QMLTQGAGNR KFKCTECGKA FKYKHHLKEH 

       310        320        330        340        350        360 
LRIHSGEKPY ECPNCKKRFS HSGSYSSHIS SKKCIGLISV NGRMRNNIKT GSSPNSVSSS 

       370        380        390        400        410        420 
PTNSAITQLR NKLENGKPLS MSEQTGLLKI KTEPLDFNDY KVLMATHGFS GTSPFMNGGL 

       430        440        450        460        470        480 
GATSPLGVHP SAQSPMQHLG VGMEAPLLGF PTMNSNLSEV QKVLQIVDNT VSRQKMDCKA 

       490        500        510        520        530        540 
EEISKLKGYH MKDPCSQPEE QGVTSPNIPP VGLPVVSHNG ATKSIIDYTL EKVNEAKACL 

       550        560        570        580        590        600 
QSLTTDSRRQ ISNIKKEKLR TLIDLVTDDK MIENHNISTP FSCQFCKESF PGPIPLHQHE 

       610        620        630        640        650        660 
RYLCKMNEEI KAVLQPHENI VPNKAGVFVD NKALLLSSVL SEKGMTSPIN PYKDHMSVLK 

       670        680        690        700        710        720 
AYYAMNMEPN SDELLKISIA VGLPQEFVKE WFEQRKVYQY SNSRSPSLER SSKPLAPNSN 

       730        740        750        760        770        780 
PPTKDSLLPR SPVKPMDSIT SPSIAELHNS VTNCDPPLRL TKPSHFTNIK PVEKLDHSRS 

       790        800        810        820        830        840 
NTPSPLNLSS TSSKNSHSSS YTPNSFSSEE LQAEPLDLSL PKQMKEPKSI IATKNKTKAS 

       850        860        870        880        890        900 
SISLDHNSVS SSSENSDEPL NLTFIKKEFS NSNNLDNKST NPVFSMNPFS AKPLYTALPP 

       910        920        930        940        950        960 
QSAFPPATFM PPVQTSIPGL RPYPGLDQMS FLPHMAYTYP TGAATFADMQ QRRKYQRKQG 

       970        980        990       1000       1010       1020 
FQGELLDGAQ DYMSGLDDMT DSDSCLSRKK IKKTESGMYA CDLCDKTFQK SSSLLRHKYE 

      1030       1040       1050       1060       1070       1080 
HTGKRPHQCQ ICKKAFKHKH HLIEHSRLHS GEKPYQCDKC GKRFSHSGSY SQHMNHRYSY 

      1090       1100       1110       1120       1130       1140 
CKREAEEREA AEREAREKGH LEPTELLMNR AYLQSITPQG YSDSEERESM PRDGESEKEH 

      1150       1160       1170       1180       1190       1200 
EKEGEDGYGK LGRQDGDEEF EEEEEESENK SMDTDPETIR DEEETGDHSM DDSSEDGKME 

      1210 
TKSDHEEDNM EDGM 

« Hide

Isoform 2 [UniParc].

Checksum: B9E3278A9EEF8AAC
Show »

FASTA1,190133,806

References

« Hide 'large scale' references
[1]"Loss-of-function mutations in SIP1 Smad interacting protein 1 result in a syndromic Hirschsprung disease."
Cacheux V., Dastot-Le Moal F., Kaeaeriaeinen H., Bondurand N., Rintala R., Boissier B., Wilson M., Mowat D., Goossens M.
Hum. Mol. Genet. 10:1503-1510(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INVOLVEMENT IN MOWS.
[2]"Mutations in SIP1, encoding Smad interacting protein 1, cause a form of Hirschsprung disease."
Wakamatsu N., Yamada Y., Yamada K., Ono T., Nomura N., Taniguchi H., Kitoh H., Mutoh N., Yamanaka T., Mushiake K., Kato K., Sonta S., Nagaya M.
Nat. Genet. 27:369-370(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]"Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[5]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[7]"Selection system for genes encoding nuclear-targeted proteins."
Ueki N., Oda T., Kondo M., Yano K., Noguchi T., Muramatsu M.-A.
Nat. Biotechnol. 16:1338-1342(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1161-1214 (ISOFORM 1), SUBCELLULAR LOCATION.
Tissue: Fetal brain.
[8]"Pc2-mediated sumoylation of Smad-interacting protein 1 attenuates transcriptional repression of E-cadherin."
Long J., Zuo D., Park M.
J. Biol. Chem. 280:35477-35489(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUMOYLATION AT LYS-391 AND LYS-866, INTERACTION WITH CBX4 AND CTBP1, SUBCELLULAR LOCATION.
[9]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-377, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]"Solution structure of the homeobox domain of zinc finger homeobox protein 1B (SMAD interacting protein 1)."
RIKEN structural genomics initiative (RSGI)
Submitted (DEC-2006) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 647-705.
[11]"Late infantile Hirschsprung disease-mental retardation syndrome with a 3-bp deletion in ZFHX1B."
Yoneda M., Fujita T., Yamada Y., Yamada K., Fujii A., Inagaki T., Nakagawa H., Shimada A., Kishikawa M., Nagaya M., Azuma T., Kuriyama M., Wakamatsu N.
Neurology 59:1637-1640(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT MOWS ASN-99 DEL.
[12]"Ocular coloboma and high myopia with Hirschsprung disease associated with a novel ZFHX1B missense mutation and trisomy 21."
Gregory-Evans C.Y., Vieira H., Dalton R., Adams G.G.W., Salt A., Gregory-Evans K.
Am. J. Med. Genet. A 131:86-90(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT MOWS GLY-953.
[13]"A missense mutation in the ZFHX1B gene associated with an atypical Mowat-Wilson syndrome phenotype."
Heinritz W., Zweier C., Froster U.G., Strenge S., Kujat A., Syrbe S., Rauch A., Schuster V.
Am. J. Med. Genet. A 140:1223-1227(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT MOWS ARG-1119.
[14]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-983.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY029472 Genomic DNA. Translation: AAK52081.1.
AB056507 mRNA. Translation: BAB40819.1.
AB011141 mRNA. Translation: BAA25495.2. Different initiation.
AK294928 mRNA. Translation: BAH11928.1.
AC009951 Genomic DNA. No translation available.
AC010130 Genomic DNA. No translation available.
BC127102 mRNA. Translation: AAI27103.1.
AB015341 mRNA. Translation: BAA34798.1.
RefSeqNP_001165124.1. NM_001171653.1.
NP_055610.1. NM_014795.3.
UniGeneHs.34871.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2DA7NMR-A647-704[»]
ProteinModelPortalO60315.
SMRO60315. Positions 132-366, 648-705, 959-1090.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115175. 21 interactions.
IntActO60315. 11 interactions.
MINTMINT-1181379.
STRING9606.ENSP00000302501.

PTM databases

PhosphoSiteO60315.

Proteomic databases

PaxDbO60315.
PRIDEO60315.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000303660; ENSP00000302501; ENSG00000169554. [O60315-1]
ENST00000409487; ENSP00000386854; ENSG00000169554. [O60315-1]
ENST00000539609; ENSP00000443792; ENSG00000169554. [O60315-2]
ENST00000558170; ENSP00000454157; ENSG00000169554. [O60315-1]
GeneID9839.
KEGGhsa:9839.
UCSCuc002tvu.3. human. [O60315-1]

Organism-specific databases

CTD9839.
GeneCardsGC02M145121.
HGNCHGNC:14881. ZEB2.
HPAHPA003456.
MIM235730. phenotype.
605802. gene.
neXtProtNX_O60315.
Orphanet261552. Mowat-Wilson syndrome due to a point mutation.
261537. Mowat-Wilson syndrome due to monosomy 2q22.
PharmGKBPA162409612.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000264256.
HOVERGENHBG004697.
InParanoidO60315.
KOK09299.
OMAEKLDHSR.
OrthoDBEOG790G0D.
PhylomeDBO60315.
TreeFamTF331759.

Enzyme and pathway databases

SignaLinkO60315.

Gene expression databases

ArrayExpressO60315.
BgeeO60315.
CleanExHS_SIP1.
HS_ZEB2.
GenevestigatorO60315.

Family and domain databases

Gene3D3.30.160.60. 5 hits.
InterProIPR008598. Di19_Zn_binding.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF05605. zf-Di19. 1 hit.
[Graphical view]
SMARTSM00389. HOX. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSZEB2. human.
EvolutionaryTraceO60315.
GeneWikiZEB2.
GenomeRNAi9839.
NextBio37070.
PROO60315.
SOURCESearch...

Entry information

Entry nameZEB2_HUMAN
AccessionPrimary (citable) accession number: O60315
Secondary accession number(s): A0JP09 expand/collapse secondary AC list , B7Z2P2, F5H814, Q9UED1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: August 1, 1998
Last modified: April 16, 2014
This is version 151 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM