##gff-version 3 O60312 UniProtKB Chain 1 1499 . . . ID=PRO_0000046379;Note=Phospholipid-transporting ATPase VA O60312 UniProtKB Topological domain 1 86 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 O60312 UniProtKB Transmembrane 87 106 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 O60312 UniProtKB Topological domain 107 110 . . . Note=Exoplasmic loop;Ontology_term=ECO:0000255;evidence=ECO:0000255 O60312 UniProtKB Transmembrane 111 128 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 O60312 UniProtKB Topological domain 129 309 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 O60312 UniProtKB Transmembrane 310 332 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 O60312 UniProtKB Topological domain 333 362 . . . Note=Exoplasmic loop;Ontology_term=ECO:0000255;evidence=ECO:0000255 O60312 UniProtKB Transmembrane 363 384 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 O60312 UniProtKB Topological domain 385 1087 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 O60312 UniProtKB Transmembrane 1088 1108 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 O60312 UniProtKB Topological domain 1109 1119 . . . Note=Exoplasmic loop;Ontology_term=ECO:0000255;evidence=ECO:0000255 O60312 UniProtKB Transmembrane 1120 1140 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 O60312 UniProtKB Topological domain 1141 1170 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 O60312 UniProtKB Transmembrane 1171 1192 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 O60312 UniProtKB Topological domain 1193 1199 . . . Note=Exoplasmic loop;Ontology_term=ECO:0000255;evidence=ECO:0000255 O60312 UniProtKB Transmembrane 1200 1222 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 O60312 UniProtKB Topological domain 1223 1228 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 O60312 UniProtKB Transmembrane 1229 1249 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 O60312 UniProtKB Topological domain 1250 1267 . . . Note=Exoplasmic loop;Ontology_term=ECO:0000255;evidence=ECO:0000255 O60312 UniProtKB Transmembrane 1268 1292 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 O60312 UniProtKB Topological domain 1293 1499 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 O60312 UniProtKB Region 1 53 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O60312 UniProtKB Region 464 531 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O60312 UniProtKB Region 1311 1356 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O60312 UniProtKB Region 1464 1499 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O60312 UniProtKB Compositional bias 1 17 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O60312 UniProtKB Compositional bias 479 495 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O60312 UniProtKB Compositional bias 1340 1356 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O60312 UniProtKB Active site 427 427 . . . Note=4-aspartylphosphate intermediate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9HD20 O60312 UniProtKB Binding site 427 427 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Y2Q0 O60312 UniProtKB Binding site 427 427 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Y2Q0 O60312 UniProtKB Binding site 428 428 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Y2Q0 O60312 UniProtKB Binding site 429 429 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Y2Q0 O60312 UniProtKB Binding site 429 429 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Y2Q0 O60312 UniProtKB Binding site 700 700 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04191 O60312 UniProtKB Binding site 742 742 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Y2Q0 O60312 UniProtKB Binding site 766 766 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04191 O60312 UniProtKB Binding site 809 809 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04191 O60312 UniProtKB Binding site 889 889 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04191 O60312 UniProtKB Binding site 890 890 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04191 O60312 UniProtKB Binding site 891 891 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04191 O60312 UniProtKB Binding site 1005 1005 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04191 O60312 UniProtKB Binding site 1011 1011 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04191 O60312 UniProtKB Binding site 1031 1031 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8NB49 O60312 UniProtKB Binding site 1034 1034 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Y2Q0 O60312 UniProtKB Binding site 1035 1035 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Y2Q0 O60312 UniProtKB Binding site 1035 1035 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8NB49 O60312 UniProtKB Modified residue 466 466 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O54827 O60312 UniProtKB Alternative sequence 150 155 . . . ID=VSP_056604;Note=In isoform 2. REEKKY->SRSHLK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 O60312 UniProtKB Alternative sequence 156 1499 . . . ID=VSP_056605;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 O60312 UniProtKB Natural variant 208 208 . . . ID=VAR_078700;Note=Found in a patient with autism and Parkinson's disease%3B uncertain significance. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26637798;Dbxref=dbSNP:rs763246380,PMID:26637798 O60312 UniProtKB Natural variant 353 353 . . . ID=VAR_048380;Note=S->Y;Dbxref=dbSNP:rs17116056 O60312 UniProtKB Natural variant 504 504 . . . ID=VAR_061038;Note=R->H;Dbxref=dbSNP:rs56724944 O60312 UniProtKB Natural variant 532 532 . . . ID=VAR_022004;Note=T->M;Dbxref=dbSNP:rs2066703 O60312 UniProtKB Natural variant 784 784 . . . ID=VAR_022005;Note=A->T;Dbxref=dbSNP:rs2066704 O60312 UniProtKB Natural variant 834 834 . . . ID=VAR_048381;Note=E->K;Dbxref=dbSNP:rs17555920 O60312 UniProtKB Natural variant 1172 1172 . . . ID=VAR_022006;Note=W->C;Dbxref=dbSNP:rs2076742 O60312 UniProtKB Natural variant 1179 1179 . . . ID=VAR_022007;Note=A->T;Dbxref=dbSNP:rs2076744 O60312 UniProtKB Natural variant 1188 1188 . . . ID=VAR_022008;Note=I->V;Dbxref=dbSNP:rs2076745 O60312 UniProtKB Natural variant 1198 1198 . . . ID=VAR_048382;Note=V->M;Dbxref=dbSNP:rs2076746 O60312 UniProtKB Natural variant 1298 1298 . . . ID=VAR_022009;Note=R->S;Dbxref=dbSNP:rs3816800 O60312 UniProtKB Natural variant 1397 1397 . . . ID=VAR_048383;Note=A->V;Dbxref=dbSNP:rs9324127 O60312 UniProtKB Mutagenesis 98 99 . . . Note=Decreases PC-flipping activity. NF->QA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30530492;Dbxref=PMID:30530492 O60312 UniProtKB Mutagenesis 203 203 . . . Note=Impairs PC-flipping activity. E->Q;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:25947375,ECO:0000269|PubMed:29599178,ECO:0000269|PubMed:30530492;Dbxref=PMID:25947375,PMID:29599178,PMID:30530492 O60312 UniProtKB Sequence conflict 388 388 . . . Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305