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O60312

- AT10A_HUMAN

UniProt

O60312 - AT10A_HUMAN

Protein

Probable phospholipid-transporting ATPase VA

Gene

ATP10A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 143 (01 Oct 2014)
      Sequence version 2 (13 Aug 2002)
      Previous versions | rss
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    Functioni

    Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules Probable.Curated

    Catalytic activityi

    ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei427 – 42714-aspartylphosphate intermediateBy similarity
    Metal bindingi1031 – 10311MagnesiumBy similarity
    Metal bindingi1035 – 10351MagnesiumBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cation-transporting ATPase activity Source: InterPro
    3. magnesium ion binding Source: InterPro
    4. phospholipid-translocating ATPase activity Source: UniProtKB
    5. protein binding Source: UniProtKB

    GO - Biological processi

    1. ion transmembrane transport Source: Reactome
    2. phospholipid translocation Source: UniProtKB
    3. regulation of cell shape Source: UniProtKB
    4. transmembrane transport Source: Reactome

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid transport, Transport

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_25149. Ion transport by P-type ATPases.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable phospholipid-transporting ATPase VA (EC:3.6.3.1)
    Alternative name(s):
    ATPase class V type 10A
    Aminophospholipid translocase VA
    P4-ATPase flippase complex alpha subunit ATP10A
    Gene namesi
    Name:ATP10A
    Synonyms:ATP10C, ATPVA, ATPVC, KIAA0566
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:13542. ATP10A.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication. Endoplasmic reticulum membrane 1 Publication
    Note: Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not that of TMEM30B.

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB
    2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB
    4. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Angelman syndrome (AS) [MIM:105830]: A neurodevelopmental disorder characterized by severe motor and intellectual retardation, ataxia, frequent jerky limb movements and flapping of the arms and hands, hypotonia, seizures, absence of speech, frequent smiling and episodes of paroxysmal laughter, open-mouthed expression revealing the tongue.
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Organism-specific databases

    MIMi105830. phenotype.
    Orphaneti72. Angelman syndrome.
    PharmGKBiPA25097.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14991499Probable phospholipid-transporting ATPase VAPRO_0000046379Add
    BLAST

    Proteomic databases

    PaxDbiO60312.
    PRIDEiO60312.

    PTM databases

    PhosphoSiteiO60312.

    Expressioni

    Tissue specificityi

    Widely expressed, with highest levels in kidney, followed by lung, brain, prostate, testis, ovary and small intestine.

    Gene expression databases

    ArrayExpressiO60312.
    BgeeiO60312.
    CleanExiHS_ATP10A.
    GenevestigatoriO60312.

    Organism-specific databases

    HPAiHPA041496.
    HPA042509.

    Interactioni

    Subunit structurei

    Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit and an accessory beta subunit.Curated

    Protein-protein interaction databases

    STRINGi9606.ENSP00000349325.

    Structurei

    3D structure databases

    ProteinModelPortaliO60312.
    SMRiO60312. Positions 1010-1066.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 8686CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini107 – 1104Exoplasmic loopSequence Analysis
    Topological domaini129 – 309181CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini333 – 36230Exoplasmic loopSequence AnalysisAdd
    BLAST
    Topological domaini385 – 1087703CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1109 – 111911Exoplasmic loopSequence AnalysisAdd
    BLAST
    Topological domaini1141 – 117030CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1193 – 11997Exoplasmic loopSequence Analysis
    Topological domaini1223 – 12286CytoplasmicSequence Analysis
    Topological domaini1250 – 126718Exoplasmic loopSequence AnalysisAdd
    BLAST
    Topological domaini1293 – 1499207CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei87 – 10620HelicalSequence AnalysisAdd
    BLAST
    Transmembranei111 – 12818HelicalSequence AnalysisAdd
    BLAST
    Transmembranei310 – 33223HelicalSequence AnalysisAdd
    BLAST
    Transmembranei363 – 38422HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1088 – 110821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1120 – 114021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1171 – 119222HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1200 – 122223HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1229 – 124921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1268 – 129225HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi467 – 4704Poly-Glu

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0474.
    HOGENOMiHOG000202528.
    HOVERGENiHBG107129.
    InParanoidiO60312.
    KOiK01530.
    OMAiWRYQEKK.
    OrthoDBiEOG76471S.
    PhylomeDBiO60312.
    TreeFamiTF354252.

    Family and domain databases

    Gene3Di2.70.150.10. 2 hits.
    3.40.1110.10. 3 hits.
    3.40.50.1000. 2 hits.
    InterProiIPR023299. ATPase_P-typ_cyto_domN.
    IPR018303. ATPase_P-typ_P_site.
    IPR006539. ATPase_P-typ_Plipid-transp.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view]
    PANTHERiPTHR24092. PTHR24092. 1 hit.
    PfamiPF00122. E1-E2_ATPase. 1 hit.
    [Graphical view]
    PRINTSiPR00119. CATATPASE.
    SUPFAMiSSF56784. SSF56784. 2 hits.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsiTIGR01652. ATPase-Plipid. 2 hits.
    TIGR01494. ATPase_P-type. 2 hits.
    PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O60312-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEREPAGTEE PGPPGRRRRR EGRTRTVRSN LLPPPGAEDP AAGAAKGERR     50
    RRRGCAQHLA DNRLKTTKYT LLSFLPKNLF EQFHRPANVY FVFIALLNFV 100
    PAVNAFQPGL ALAPVLFILA ITAFRDLWED YSRHRSDHKI NHLGCLVFSR 150
    EEKKYVNRFW KEIHVGDFVR LRCNEIFPAD ILLLSSSDPD GLCHIETANL 200
    DGETNLKRRQ VVRGFSELVS EFNPLTFTSV IECEKPNNDL SRFRGCIIHD 250
    NGKKAGLYKE NLLLRGCTLR NTDAVVGIVI YAGHETKALL NNSGPRYKRS 300
    KLERQMNCDV LWCVLLLVCM SLFSAVGHGL WIWRYQEKKS LFYVPKSDGS 350
    SLSPVTAAVY SFLTMIIVLQ VLIPISLYVS IEIVKACQVY FINQDMQLYD 400
    EETDSQLQCR ALNITEDLGQ IQYIFSDKTG TLTENKMVFR RCTVSGVEYS 450
    HDANAQRLAR YQEADSEEEE VVPRGGSVSQ RGSIGSHQSV RVVHRTQSTK 500
    SHRRTGSRAE AKRASMLSKH TAFSSPMEKD ITPDPKLLEK VSECDKSLAV 550
    ARHQEHLLAH LSPELSDVFD FFIALTICNT VVVTSPDQPR TKVRVRFELK 600
    SPVKTIEDFL RRFTPSCLTS GCSSIGSLAA NKSSHKLGSS FPSTPSSDGM 650
    LLRLEERLGQ PTSAIASNGY SSQADNWASE LAQEQESERE LRYEAESPDE 700
    AALVYAARAY NCVLVERLHD QVSVELPHLG RLTFELLHTL GFDSVRKRMS 750
    VVIRHPLTDE INVYTKGADS VVMDLLQPCS SVDARGRHQK KIRSKTQNYL 800
    NVYAAEGLRT LCIAKRVLSK EEYACWLQSH LEAESSLENS EELLFQSAIR 850
    LETNLHLLGA TGIEDRLQDG VPETISKLRQ AGLQIWVLTG DKQETAVNIA 900
    YACKLLDHDE EVITLNATSQ EACAALLDQC LCYVQSRGLQ RAPEKTKGKV 950
    SMRFSSLCPP STSTASGRRP SLVIDGRSLA YALEKNLEDK FLFLAKQCRS 1000
    VLCCRSTPLQ KSMVVKLVRS KLKAMTLAIG DGANDVSMIQ VADVGVGISG 1050
    QEGMQAVMAS DFAVPKFRYL ERLLILHGHW CYSRLANMVL YFFYKNTMFV 1100
    GLLFWFQFFC GFSASTMIDQ WYLIFFNLLF SSLPPLVTGV LDRDVPANVL 1150
    LTNPQLYKSG QNMEEYRPRT FWFNMADAAF QSLVCFSIPY LAYYDSNVDL 1200
    FTWGTPIVTI ALLTFLLHLG IETKTWTWLN WITCGFSVLL FFTVALIYNA 1250
    SCATCYPPSN PYWTMQALLG DPVFYLTCLM TPVAALLPRL FFRSLQGRVF 1300
    PTQLQLARQL TRKSPRRCSA PKETFAQGRL PKDSGTEHSS GRTVKTSVPL 1350
    SQPSWHTQQP VCSLEASGEP STVDMSMPVR EHTLLEGLSA PAPMSSAPGE 1400
    AVLRSPGGCP EESKVRAAST GRVTPLSSLF SLPTFSLLNW ISSWSLVSRL 1450
    GSVLQFSRTE QLADGQAGRG LPVQPHSGRS GLQGPDHRLL IGASSRRSQ 1499
    Length:1,499
    Mass (Da):167,688
    Last modified:August 13, 2002 - v2
    Checksum:iD4996A4D0635A68D
    GO
    Isoform 2 (identifier: O60312-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         150-155: REEKKY → SRSHLK
         156-1499: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:155
    Mass (Da):17,610
    Checksum:i687DF574B01D70F2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti388 – 3881Q → R in BAA25492. (PubMed:9628581)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti353 – 3531S → Y.
    Corresponds to variant rs17116056 [ dbSNP | Ensembl ].
    VAR_048380
    Natural varianti504 – 5041R → H.
    Corresponds to variant rs56724944 [ dbSNP | Ensembl ].
    VAR_061038
    Natural varianti532 – 5321T → M.
    Corresponds to variant rs2066703 [ dbSNP | Ensembl ].
    VAR_022004
    Natural varianti784 – 7841A → T.
    Corresponds to variant rs2066704 [ dbSNP | Ensembl ].
    VAR_022005
    Natural varianti834 – 8341E → K.
    Corresponds to variant rs17555920 [ dbSNP | Ensembl ].
    VAR_048381
    Natural varianti1172 – 11721W → C.
    Corresponds to variant rs2076742 [ dbSNP | Ensembl ].
    VAR_022006
    Natural varianti1179 – 11791A → T.
    Corresponds to variant rs2076744 [ dbSNP | Ensembl ].
    VAR_022007
    Natural varianti1188 – 11881I → V.
    Corresponds to variant rs2076745 [ dbSNP | Ensembl ].
    VAR_022008
    Natural varianti1198 – 11981V → M.
    Corresponds to variant rs2076746 [ dbSNP | Ensembl ].
    VAR_048382
    Natural varianti1298 – 12981R → S.
    Corresponds to variant rs3816800 [ dbSNP | Ensembl ].
    VAR_022009
    Natural varianti1397 – 13971A → V.
    Corresponds to variant rs9324127 [ dbSNP | Ensembl ].
    VAR_048383

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei150 – 1556REEKKY → SRSHLK in isoform 2. 1 PublicationVSP_056604
    Alternative sequencei156 – 14991344Missing in isoform 2. 1 PublicationVSP_056605Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB051358 mRNA. Translation: BAB47392.1.
    AY029504
    , AY029487, AY029488, AY029489, AY029490, AY029491, AY029492, AY029493, AY029494, AY029495, AY029496, AY029497, AY029498, AY029499, AY029500, AY029501, AY029502, AY029503 Genomic DNA. Translation: AAK33100.1.
    AC016266 Genomic DNA. No translation available.
    AC023449 Genomic DNA. No translation available.
    AC109512 Genomic DNA. No translation available.
    BC052251 mRNA. Translation: AAH52251.1.
    BC038712 mRNA. Translation: AAH38712.1.
    AB011138 mRNA. Translation: BAA25492.1.
    CCDSiCCDS32178.1.
    RefSeqiNP_077816.1. NM_024490.3.
    XP_005268318.1. XM_005268261.2.
    UniGeneiHs.659258.

    Genome annotation databases

    EnsembliENST00000356865; ENSP00000349325; ENSG00000206190.
    ENST00000389967; ENSP00000374617; ENSG00000206190.
    GeneIDi57194.
    KEGGihsa:57194.
    UCSCiuc010ayu.3. human.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB051358 mRNA. Translation: BAB47392.1 .
    AY029504
    , AY029487 , AY029488 , AY029489 , AY029490 , AY029491 , AY029492 , AY029493 , AY029494 , AY029495 , AY029496 , AY029497 , AY029498 , AY029499 , AY029500 , AY029501 , AY029502 , AY029503 Genomic DNA. Translation: AAK33100.1 .
    AC016266 Genomic DNA. No translation available.
    AC023449 Genomic DNA. No translation available.
    AC109512 Genomic DNA. No translation available.
    BC052251 mRNA. Translation: AAH52251.1 .
    BC038712 mRNA. Translation: AAH38712.1 .
    AB011138 mRNA. Translation: BAA25492.1 .
    CCDSi CCDS32178.1.
    RefSeqi NP_077816.1. NM_024490.3.
    XP_005268318.1. XM_005268261.2.
    UniGenei Hs.659258.

    3D structure databases

    ProteinModelPortali O60312.
    SMRi O60312. Positions 1010-1066.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000349325.

    PTM databases

    PhosphoSitei O60312.

    Proteomic databases

    PaxDbi O60312.
    PRIDEi O60312.

    Protocols and materials databases

    DNASUi 57194.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000356865 ; ENSP00000349325 ; ENSG00000206190 .
    ENST00000389967 ; ENSP00000374617 ; ENSG00000206190 .
    GeneIDi 57194.
    KEGGi hsa:57194.
    UCSCi uc010ayu.3. human.

    Organism-specific databases

    CTDi 57194.
    GeneCardsi GC15M025923.
    GeneReviewsi ATP10A.
    HGNCi HGNC:13542. ATP10A.
    HPAi HPA041496.
    HPA042509.
    MIMi 105830. phenotype.
    605855. gene.
    neXtProti NX_O60312.
    Orphaneti 72. Angelman syndrome.
    PharmGKBi PA25097.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0474.
    HOGENOMi HOG000202528.
    HOVERGENi HBG107129.
    InParanoidi O60312.
    KOi K01530.
    OMAi WRYQEKK.
    OrthoDBi EOG76471S.
    PhylomeDBi O60312.
    TreeFami TF354252.

    Enzyme and pathway databases

    Reactomei REACT_25149. Ion transport by P-type ATPases.

    Miscellaneous databases

    GeneWikii ATP10A.
    GenomeRNAii 57194.
    NextBioi 63284.
    PROi O60312.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O60312.
    Bgeei O60312.
    CleanExi HS_ATP10A.
    Genevestigatori O60312.

    Family and domain databases

    Gene3Di 2.70.150.10. 2 hits.
    3.40.1110.10. 3 hits.
    3.40.50.1000. 2 hits.
    InterProi IPR023299. ATPase_P-typ_cyto_domN.
    IPR018303. ATPase_P-typ_P_site.
    IPR006539. ATPase_P-typ_Plipid-transp.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view ]
    PANTHERi PTHR24092. PTHR24092. 1 hit.
    Pfami PF00122. E1-E2_ATPase. 1 hit.
    [Graphical view ]
    PRINTSi PR00119. CATATPASE.
    SUPFAMi SSF56784. SSF56784. 2 hits.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsi TIGR01652. ATPase-Plipid. 2 hits.
    TIGR01494. ATPase_P-type. 2 hits.
    PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel maternally expressed gene, ATP10C, encodes a putative aminophospholipid translocase associated with Angelman syndrome."
      Meguro M., Kashiwagi A., Mitsuya K., Nakao M., Kondo I., Saitoh S., Oshimura M.
      Nat. Genet. 28:19-20(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "The human aminophospholipid-transporting ATPase gene ATP10C maps adjacent to UBE3A and exhibits similar imprinted expression."
      Herzing L.B.K., Kim S.-J., Cook E.H. Jr., Ledbetter D.H.
      Am. J. Hum. Genet. 68:1501-1505(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Skin and Testis.
    5. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 337-1499 (ISOFORM 1).
      Tissue: Brain.
    6. "ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner."
      Takatsu H., Baba K., Shima T., Umino H., Kato U., Umeda M., Nakayama K., Shin H.W.
      J. Biol. Chem. 286:38159-38167(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiAT10A_HUMAN
    AccessioniPrimary (citable) accession number: O60312
    Secondary accession number(s): Q4G0S9, Q969I4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: August 13, 2002
    Last modified: October 1, 2014
    This is version 143 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3