Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Leucine-rich repeat-containing protein 37A3

Gene

LRRC37A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 37A3
Gene namesi
Name:LRRC37A3
Synonyms:KIAA0563
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:32427. LRRC37A3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini36 – 1581ExtracellularSequence analysisAdd BLAST1546
Transmembranei1582 – 1602HelicalSequence analysisAdd BLAST21
Topological domaini1603 – 1634CytoplasmicSequence analysisAdd BLAST32

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000176809.
PharmGKBiPA162394563.

Polymorphism and mutation databases

BioMutaiLRRC37A3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35Sequence analysisAdd BLAST35
ChainiPRO_000007624436 – 1634Leucine-rich repeat-containing protein 37A3Add BLAST1599

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi296N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1079N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiO60309.
PaxDbiO60309.
PeptideAtlasiO60309.
PRIDEiO60309.

PTM databases

iPTMnetiO60309.
PhosphoSitePlusiO60309.

Expressioni

Gene expression databases

BgeeiENSG00000176809.
CleanExiHS_LRRC37A3.
ExpressionAtlasiO60309. baseline and differential.
GenevisibleiO60309. HS.

Organism-specific databases

HPAiHPA042121.
HPA042701.
HPA043056.
HPA045090.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000325713.

Structurei

3D structure databases

ProteinModelPortaliO60309.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati137 – 160LRR 1Add BLAST24
Repeati230 – 253LRR 2Add BLAST24
Repeati267 – 290LRR 3Add BLAST24
Repeati864 – 887LRR 4Add BLAST24
Repeati888 – 911LRR 5Add BLAST24
Repeati912 – 935LRR 6Add BLAST24
Repeati937 – 959LRR 7Add BLAST23
Repeati963 – 987LRR 8Add BLAST25
Repeati1002 – 1027LRR 9Add BLAST26
Repeati1124 – 1146LRR 10Add BLAST23
Repeati1151 – 1176LRR 11Add BLAST26
Repeati1359 – 1384LRR 12Add BLAST26

Sequence similaritiesi

Belongs to the LRRC37A family.Curated
Contains 12 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJNR. Eukaryota.
ENOG410YV94. LUCA.
GeneTreeiENSGT00530000063282.
HOGENOMiHOG000113269.
HOVERGENiHBG100009.
InParanoidiO60309.
OMAiSANICEL.
OrthoDBiEOG091G006W.
PhylomeDBiO60309.
TreeFamiTF341959.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR032754. LRRC37_N.
IPR015753. LRRC37A/B-like.
IPR029423. LRRC37AB_C.
[Graphical view]
PANTHERiPTHR23045. PTHR23045. 1 hit.
PfamiPF13855. LRR_8. 1 hit.
PF15779. LRRC37. 6 hits.
PF14914. LRRC37AB_C. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O60309-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSAQCPALA CVMSPLRFWG PWPLLMWQLL WLLVKEAQPL EWVKDPLQLT
60 70 80 90 100
SNPLGPPEPW SSHSSHFPRE SPHAPTLPAD PWDFDHLGPS ASSEMPAPPQ
110 120 130 140 150
ESTENLVPFL DTWDSAGELP LEPEQFLASQ QDLKDKLSPQ ERLPVSPKKL
160 170 180 190 200
KKDPAQRWSL AEIIGIIHQL STPQSQKQTL QNEYSSTDTP YPGSLPPELR
210 220 230 240 250
VKSDEPPGPS EQVGPSQFHL EPETQNPETL EDIQSSSLQQ EAPAQLPQLL
260 270 280 290 300
EEEPSSMQQE APALPPESSM ESLTLPNHEV SVQPPGEDQA YYHLPNITVK
310 320 330 340 350
PADVEVTITS EPTNETESSQ AQQETPIQFP EEVEPSATQQ EAPIEPPVPP
360 370 380 390 400
MEHELSISEQ QQPVQPSESS REVESSPTQQ ETPGQPPEHH EVTVSPPGHH
410 420 430 440 450
QTHHLASPSV SVKPPDVQLT IAAEPSAEVG TSLVHQEATT RLSGSGNDVE
460 470 480 490 500
PPAIQHGGPP LLPESSEEAG PLAVQQETSF QSPEPINNEN PSPTQQEAAA
510 520 530 540 550
EHPQTAEEGE SSLTHQEAPA QTPEFPNVVV AQPPEHSHLT QATVQPLDLG
560 570 580 590 600
FTITPESMTE VELSPTMKET PTQPPKKVVP QLRVYQGVTN PTPGQDQAQH
610 620 630 640 650
PVSPSVTVQL LDLGLTITPE PTTEVGHSTP PKRTIVSPKH PEVTLPHPDQ
660 670 680 690 700
VQTQHSHLTR ATVQPLDLGF TITPKSMTEV EPSTALMTTA PPPGHPEVTL
710 720 730 740 750
PPSDKGQAQH SHLTQATVQP LDLELTITTK PTTEVKPSPT TEETSTQLPD
760 770 780 790 800
LGLAIIPEPT TETGHSTALE KTTAPRPDRV QTLHRSLTEV TGPPTELEPA
810 820 830 840 850
QDSLVQSESY TQNKALTAPE EHKASTSTNI CELCTCGDEM LSCIDLNPEQ
860 870 880 890 900
RLRQVPVPEP NTHNGTFTIL NFQGNYISYI DGNVWKAYSW TEKLILRENN
910 920 930 940 950
LTELHKDSFE GLLSLQYLDL SCNKIQSIER HTFEPLPFLK FINLSCNVIT
960 970 980 990 1000
ELSFGTFQAW HGMQFLHKLI LNHNPLTTVE DPYLFKLPAL KYLDMGTTLV
1010 1020 1030 1040 1050
PLTTLKNILM MTVELEKLIV PSHMACCLCQ FKNSIEAVCK TVKLHCNSAC
1060 1070 1080 1090 1100
LTNTTHCPEE ASVGNPEGAF MKVLQARKNY TSTELIIEPE EPSDSSGINL
1110 1120 1130 1140 1150
SGFGSEQLDT NDESDVTSTL SYILPYFSAV NLDVKSLLLP FIKLPTTGNS
1160 1170 1180 1190 1200
LAKIQTVGKN RQRLNRVLMG PRSIQKRHFK EVGRQSIRRE QGAQASVENT
1210 1220 1230 1240 1250
AEEKRLGSPA PRELKQPHTQ QGPEKLAGNA VYTKPSFTQE HKAAVSVLKP
1260 1270 1280 1290 1300
FSKGAPSTSS PAKALPQVRD RWKDLTHAIS ILESAKARVT NMKTSKPIVH
1310 1320 1330 1340 1350
SRKKYRFHKT RSRMTHRTPK VKKSPKVRKK SYLSRLMLSN RLPFSAAKSL
1360 1370 1380 1390 1400
INSPSQGAFS SLRDLSPQEN PFLEVSAPSE HFIENNNTKD TTARNAFEEN
1410 1420 1430 1440 1450
VFMENTNMPE GTISENTNYN HPPEADSAGT AFNLGPTVKQ TETKWEYNNV
1460 1470 1480 1490 1500
GTDLSPEPKS FNYPLLSSPG DQFEIQLTQQ LQSVIPNNNV RRLIAHVIRT
1510 1520 1530 1540 1550
LKMDCSGAHV QVTCAKLVSR TGHLMKLLSG QQEVKASKIE WDTDQWKTEN
1560 1570 1580 1590 1600
YINESTEAQS EQKEKSLEFT KELPGYGYTK KLILALIVTG ILTILIILLC
1610 1620 1630
LIEICCHRRS LQEDEEGFSR DSEAPTEEES EALP
Length:1,634
Mass (Da):180,621
Last modified:December 6, 2005 - v2
Checksum:i84C8F93290B29EB1
GO

Sequence cautioni

The sequence BAA25489 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC03710 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti51S → P in AAH43145 (PubMed:15489334).Curated1
Sequence conflicti1086I → T in AAH43145 (PubMed:15489334).Curated1
Sequence conflicti1417T → A in AAH43145 (PubMed:15489334).Curated1
Sequence conflicti1419Y → H in BAC03710 (PubMed:14702039).Curated1
Sequence conflicti1619S → P in BAC03710 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0510881215K → E.Corresponds to variant rs9893710dbSNPEnsembl.1
Natural variantiVAR_0616721590G → A.Corresponds to variant rs28532307dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011135 mRNA. Translation: BAA25489.3. Different initiation.
BC043145 mRNA. Translation: AAH43145.1.
AK091625 mRNA. Translation: BAC03710.1. Different initiation.
CCDSiCCDS32708.1.
RefSeqiNP_955372.2. NM_199340.3.
UniGeneiHs.551962.
Hs.744157.
Hs.744758.

Genome annotation databases

EnsembliENST00000319651; ENSP00000325713; ENSG00000176809.
ENST00000584306; ENSP00000464535; ENSG00000176809.
GeneIDi374819.
KEGGihsa:374819.
UCSCiuc002jey.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011135 mRNA. Translation: BAA25489.3. Different initiation.
BC043145 mRNA. Translation: AAH43145.1.
AK091625 mRNA. Translation: BAC03710.1. Different initiation.
CCDSiCCDS32708.1.
RefSeqiNP_955372.2. NM_199340.3.
UniGeneiHs.551962.
Hs.744157.
Hs.744758.

3D structure databases

ProteinModelPortaliO60309.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000325713.

PTM databases

iPTMnetiO60309.
PhosphoSitePlusiO60309.

Polymorphism and mutation databases

BioMutaiLRRC37A3.

Proteomic databases

EPDiO60309.
PaxDbiO60309.
PeptideAtlasiO60309.
PRIDEiO60309.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319651; ENSP00000325713; ENSG00000176809.
ENST00000584306; ENSP00000464535; ENSG00000176809.
GeneIDi374819.
KEGGihsa:374819.
UCSCiuc002jey.3. human.

Organism-specific databases

CTDi374819.
GeneCardsiLRRC37A3.
H-InvDBHIX0026017.
HIX0027304.
HIX0027323.
HGNCiHGNC:32427. LRRC37A3.
HPAiHPA042121.
HPA042701.
HPA043056.
HPA045090.
MIMi616557. gene.
neXtProtiNX_O60309.
OpenTargetsiENSG00000176809.
PharmGKBiPA162394563.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJNR. Eukaryota.
ENOG410YV94. LUCA.
GeneTreeiENSGT00530000063282.
HOGENOMiHOG000113269.
HOVERGENiHBG100009.
InParanoidiO60309.
OMAiSANICEL.
OrthoDBiEOG091G006W.
PhylomeDBiO60309.
TreeFamiTF341959.

Miscellaneous databases

GenomeRNAii374819.
PROiO60309.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000176809.
CleanExiHS_LRRC37A3.
ExpressionAtlasiO60309. baseline and differential.
GenevisibleiO60309. HS.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR032754. LRRC37_N.
IPR015753. LRRC37A/B-like.
IPR029423. LRRC37AB_C.
[Graphical view]
PANTHERiPTHR23045. PTHR23045. 1 hit.
PfamiPF13855. LRR_8. 1 hit.
PF15779. LRRC37. 6 hits.
PF14914. LRRC37AB_C. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiL37A3_HUMAN
AccessioniPrimary (citable) accession number: O60309
Secondary accession number(s): Q49A01, Q49A80, Q8NB33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: December 6, 2005
Last modified: November 2, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.