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Protein

Leucine-rich repeat-containing protein 37A3

Gene

LRRC37A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 37A3
Gene namesi
Name:LRRC37A3
Synonyms:KIAA0563
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:32427. LRRC37A3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini36 – 15811546ExtracellularSequence analysisAdd
BLAST
Transmembranei1582 – 160221HelicalSequence analysisAdd
BLAST
Topological domaini1603 – 163432CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162394563.

Polymorphism and mutation databases

BioMutaiLRRC37A3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3535Sequence analysisAdd
BLAST
Chaini36 – 16341599Leucine-rich repeat-containing protein 37A3PRO_0000076244Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi296 – 2961N-linked (GlcNAc...)Sequence analysis
Glycosylationi1079 – 10791N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiO60309.
PaxDbiO60309.
PRIDEiO60309.

PTM databases

iPTMnetiO60309.
PhosphoSiteiO60309.

Expressioni

Gene expression databases

BgeeiO60309.
CleanExiHS_LRRC37A3.
ExpressionAtlasiO60309. baseline and differential.
GenevisibleiO60309. HS.

Organism-specific databases

HPAiHPA042121.
HPA042701.
HPA043056.
HPA045090.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000325713.

Structurei

3D structure databases

ProteinModelPortaliO60309.
SMRiO60309. Positions 834-1044.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati137 – 16024LRR 1Add
BLAST
Repeati230 – 25324LRR 2Add
BLAST
Repeati267 – 29024LRR 3Add
BLAST
Repeati864 – 88724LRR 4Add
BLAST
Repeati888 – 91124LRR 5Add
BLAST
Repeati912 – 93524LRR 6Add
BLAST
Repeati937 – 95923LRR 7Add
BLAST
Repeati963 – 98725LRR 8Add
BLAST
Repeati1002 – 102726LRR 9Add
BLAST
Repeati1124 – 114623LRR 10Add
BLAST
Repeati1151 – 117626LRR 11Add
BLAST
Repeati1359 – 138426LRR 12Add
BLAST

Sequence similaritiesi

Belongs to the LRRC37A family.Curated
Contains 12 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJNR. Eukaryota.
ENOG410YV94. LUCA.
GeneTreeiENSGT00530000063282.
HOGENOMiHOG000113269.
HOVERGENiHBG100009.
InParanoidiO60309.
OMAiVILMEAP.
PhylomeDBiO60309.
TreeFamiTF341959.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR032754. LRRC37_N.
IPR015753. LRRC37A/B-like.
IPR029423. LRRC37AB_C.
[Graphical view]
PANTHERiPTHR23045. PTHR23045. 1 hit.
PfamiPF13855. LRR_8. 1 hit.
PF15779. LRRC37. 6 hits.
PF14914. LRRC37AB_C. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O60309-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSAQCPALA CVMSPLRFWG PWPLLMWQLL WLLVKEAQPL EWVKDPLQLT
60 70 80 90 100
SNPLGPPEPW SSHSSHFPRE SPHAPTLPAD PWDFDHLGPS ASSEMPAPPQ
110 120 130 140 150
ESTENLVPFL DTWDSAGELP LEPEQFLASQ QDLKDKLSPQ ERLPVSPKKL
160 170 180 190 200
KKDPAQRWSL AEIIGIIHQL STPQSQKQTL QNEYSSTDTP YPGSLPPELR
210 220 230 240 250
VKSDEPPGPS EQVGPSQFHL EPETQNPETL EDIQSSSLQQ EAPAQLPQLL
260 270 280 290 300
EEEPSSMQQE APALPPESSM ESLTLPNHEV SVQPPGEDQA YYHLPNITVK
310 320 330 340 350
PADVEVTITS EPTNETESSQ AQQETPIQFP EEVEPSATQQ EAPIEPPVPP
360 370 380 390 400
MEHELSISEQ QQPVQPSESS REVESSPTQQ ETPGQPPEHH EVTVSPPGHH
410 420 430 440 450
QTHHLASPSV SVKPPDVQLT IAAEPSAEVG TSLVHQEATT RLSGSGNDVE
460 470 480 490 500
PPAIQHGGPP LLPESSEEAG PLAVQQETSF QSPEPINNEN PSPTQQEAAA
510 520 530 540 550
EHPQTAEEGE SSLTHQEAPA QTPEFPNVVV AQPPEHSHLT QATVQPLDLG
560 570 580 590 600
FTITPESMTE VELSPTMKET PTQPPKKVVP QLRVYQGVTN PTPGQDQAQH
610 620 630 640 650
PVSPSVTVQL LDLGLTITPE PTTEVGHSTP PKRTIVSPKH PEVTLPHPDQ
660 670 680 690 700
VQTQHSHLTR ATVQPLDLGF TITPKSMTEV EPSTALMTTA PPPGHPEVTL
710 720 730 740 750
PPSDKGQAQH SHLTQATVQP LDLELTITTK PTTEVKPSPT TEETSTQLPD
760 770 780 790 800
LGLAIIPEPT TETGHSTALE KTTAPRPDRV QTLHRSLTEV TGPPTELEPA
810 820 830 840 850
QDSLVQSESY TQNKALTAPE EHKASTSTNI CELCTCGDEM LSCIDLNPEQ
860 870 880 890 900
RLRQVPVPEP NTHNGTFTIL NFQGNYISYI DGNVWKAYSW TEKLILRENN
910 920 930 940 950
LTELHKDSFE GLLSLQYLDL SCNKIQSIER HTFEPLPFLK FINLSCNVIT
960 970 980 990 1000
ELSFGTFQAW HGMQFLHKLI LNHNPLTTVE DPYLFKLPAL KYLDMGTTLV
1010 1020 1030 1040 1050
PLTTLKNILM MTVELEKLIV PSHMACCLCQ FKNSIEAVCK TVKLHCNSAC
1060 1070 1080 1090 1100
LTNTTHCPEE ASVGNPEGAF MKVLQARKNY TSTELIIEPE EPSDSSGINL
1110 1120 1130 1140 1150
SGFGSEQLDT NDESDVTSTL SYILPYFSAV NLDVKSLLLP FIKLPTTGNS
1160 1170 1180 1190 1200
LAKIQTVGKN RQRLNRVLMG PRSIQKRHFK EVGRQSIRRE QGAQASVENT
1210 1220 1230 1240 1250
AEEKRLGSPA PRELKQPHTQ QGPEKLAGNA VYTKPSFTQE HKAAVSVLKP
1260 1270 1280 1290 1300
FSKGAPSTSS PAKALPQVRD RWKDLTHAIS ILESAKARVT NMKTSKPIVH
1310 1320 1330 1340 1350
SRKKYRFHKT RSRMTHRTPK VKKSPKVRKK SYLSRLMLSN RLPFSAAKSL
1360 1370 1380 1390 1400
INSPSQGAFS SLRDLSPQEN PFLEVSAPSE HFIENNNTKD TTARNAFEEN
1410 1420 1430 1440 1450
VFMENTNMPE GTISENTNYN HPPEADSAGT AFNLGPTVKQ TETKWEYNNV
1460 1470 1480 1490 1500
GTDLSPEPKS FNYPLLSSPG DQFEIQLTQQ LQSVIPNNNV RRLIAHVIRT
1510 1520 1530 1540 1550
LKMDCSGAHV QVTCAKLVSR TGHLMKLLSG QQEVKASKIE WDTDQWKTEN
1560 1570 1580 1590 1600
YINESTEAQS EQKEKSLEFT KELPGYGYTK KLILALIVTG ILTILIILLC
1610 1620 1630
LIEICCHRRS LQEDEEGFSR DSEAPTEEES EALP
Length:1,634
Mass (Da):180,621
Last modified:December 6, 2005 - v2
Checksum:i84C8F93290B29EB1
GO

Sequence cautioni

The sequence BAA25489.3 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC03710.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti51 – 511S → P in AAH43145 (PubMed:15489334).Curated
Sequence conflicti1086 – 10861I → T in AAH43145 (PubMed:15489334).Curated
Sequence conflicti1417 – 14171T → A in AAH43145 (PubMed:15489334).Curated
Sequence conflicti1419 – 14191Y → H in BAC03710 (PubMed:14702039).Curated
Sequence conflicti1619 – 16191S → P in BAC03710 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1215 – 12151K → E.
Corresponds to variant rs9893710 [ dbSNP | Ensembl ].
VAR_051088
Natural varianti1590 – 15901G → A.
Corresponds to variant rs28532307 [ dbSNP | Ensembl ].
VAR_061672

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011135 mRNA. Translation: BAA25489.3. Different initiation.
BC043145 mRNA. Translation: AAH43145.1.
AK091625 mRNA. Translation: BAC03710.1. Different initiation.
CCDSiCCDS32708.1.
RefSeqiNP_955372.2. NM_199340.3.
XP_011523071.1. XM_011524769.1.
UniGeneiHs.551962.
Hs.744157.
Hs.744758.

Genome annotation databases

EnsembliENST00000319651; ENSP00000325713; ENSG00000176809.
ENST00000584306; ENSP00000464535; ENSG00000176809.
GeneIDi374819.
KEGGihsa:374819.
UCSCiuc002jey.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011135 mRNA. Translation: BAA25489.3. Different initiation.
BC043145 mRNA. Translation: AAH43145.1.
AK091625 mRNA. Translation: BAC03710.1. Different initiation.
CCDSiCCDS32708.1.
RefSeqiNP_955372.2. NM_199340.3.
XP_011523071.1. XM_011524769.1.
UniGeneiHs.551962.
Hs.744157.
Hs.744758.

3D structure databases

ProteinModelPortaliO60309.
SMRiO60309. Positions 834-1044.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000325713.

PTM databases

iPTMnetiO60309.
PhosphoSiteiO60309.

Polymorphism and mutation databases

BioMutaiLRRC37A3.

Proteomic databases

EPDiO60309.
PaxDbiO60309.
PRIDEiO60309.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319651; ENSP00000325713; ENSG00000176809.
ENST00000584306; ENSP00000464535; ENSG00000176809.
GeneIDi374819.
KEGGihsa:374819.
UCSCiuc002jey.3. human.

Organism-specific databases

CTDi374819.
GeneCardsiLRRC37A3.
H-InvDBHIX0026017.
HIX0027304.
HIX0027323.
HGNCiHGNC:32427. LRRC37A3.
HPAiHPA042121.
HPA042701.
HPA043056.
HPA045090.
MIMi616557. gene.
neXtProtiNX_O60309.
PharmGKBiPA162394563.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJNR. Eukaryota.
ENOG410YV94. LUCA.
GeneTreeiENSGT00530000063282.
HOGENOMiHOG000113269.
HOVERGENiHBG100009.
InParanoidiO60309.
OMAiVILMEAP.
PhylomeDBiO60309.
TreeFamiTF341959.

Miscellaneous databases

GenomeRNAii374819.
PROiO60309.
SOURCEiSearch...

Gene expression databases

BgeeiO60309.
CleanExiHS_LRRC37A3.
ExpressionAtlasiO60309. baseline and differential.
GenevisibleiO60309. HS.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR032754. LRRC37_N.
IPR015753. LRRC37A/B-like.
IPR029423. LRRC37AB_C.
[Graphical view]
PANTHERiPTHR23045. PTHR23045. 1 hit.
PfamiPF13855. LRR_8. 1 hit.
PF15779. LRRC37. 6 hits.
PF14914. LRRC37AB_C. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. Ohara O., Nagase T., Kikuno R., Ishikawa K.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1019-1634.
    Tissue: Fetal brain.

Entry informationi

Entry nameiL37A3_HUMAN
AccessioniPrimary (citable) accession number: O60309
Secondary accession number(s): Q49A01, Q49A80, Q8NB33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: December 6, 2005
Last modified: June 8, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.