O60308 (CE104_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Centrosomal protein of 104 kDa

Gene names

Name:	CEP104
Synonyms:	KIAA0562

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	925 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Cytoplasm › cytoskeleton › centrosome › centriole Ref.5.
Sequence similarities	Contains 2 HEAT repeats.
Sequence caution	The sequence AAH01640.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence. The sequence BAA25488.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Repeat
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	centriole Inferred from direct assay Ref.5. Source: UniProtKB
Molecular function	binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms may exist.

Isoform 1 (identifier: O60308-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O60308-2)

The sequence of this isoform differs from the canonical sequence as follows:
     189-244: RKSDYISPLD...KLKQAIADLQ → SSVRTGGEST...EGTPFQRCLV
     245-925: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: O60308-3)

The sequence of this isoform differs from the canonical sequence as follows:
     554-554: E → V
     555-925: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 925	925	Centrosomal protein of 104 kDa		PRO_0000050763
Regions
	Repeat	529 – 567	39	HEAT 1
	Repeat	604 – 640	37	HEAT 2
	Coiled coil	209 – 289	81	Potential
	Coiled coil	677 – 725	49	Potential
Amino acid modifications
	Modified residue	323	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	189 – 244	56	RKSDY…IADLQ → SSVRTGGESTFGELKGPAVP SSVTLSVLGTSLGQWFPCHL PAVDDNEGTPFQRCLV in isoform 2.		VSP_014364
	Alternative sequence	245 – 925	681	Missing in isoform 2.		VSP_014365
	Alternative sequence	554	1	E → V in isoform 3.		VSP_014366
	Alternative sequence	555 – 925	371	Missing in isoform 3.		VSP_014367
	Natural variant	414	1	L → I. Corresponds to variant rs2275824 [ dbSNP | Ensembl ].		VAR_034036
	Natural variant	686	1	A → V. Corresponds to variant rs2275831 [ dbSNP | Ensembl ].		VAR_020042
Experimental info
	Sequence conflict	51	1	V → L in AAH01640. Ref.4
	Sequence conflict	266	1	Y → F in AAH47450. Ref.4
	Sequence conflict	383	1	P → S in AAH47450. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 6B2BBD5068136887	FASTA	925	104,448
	10 20 30 40 50 60 MPHKIGFVVV SSSGHEDGFS ARELMIHAPT VSGWRSPRFC QFPQEIVLQM VERCRIRKLQ 70 80 90 100 110 120 LLAHQYMISS KIEFYISESL PEYFAPYQAE RFRRLGYVSL CDNEKTGCKA RELKSVYVDA 130 140 150 160 170 180 VGQFLKLIFH QNHVNKYNIY NQVALVAINI IGDPADFSDE SNTASREKLI DHYLGHNSED 190 200 210 220 230 240 PALEGTYARK SDYISPLDDL AFDMYQDPEV AQIIRKLDER KREAVQKERY DYAKKLKQAI 250 260 270 280 290 300 ADLQKVGERL GRYEVEKRCA VEKEDYDLAK EKKQQMEQYR AEVYEQLELH SLLDAELMRR 310 320 330 340 350 360 PFDLPLQPLA RSGSPCHQKP MPSLPQLEER GTENQFAEPF LQEKPSSYSL TISPQHSAVD 370 380 390 400 410 420 PLLPATDPHP KINAESLPYD ERPLPAIRKH YGEAVVEPEM SNADISDARR GGMLGEPEPL 430 440 450 460 470 480 TEKALREASS AIDVLGETLV AEAYCKTWSY REDALLALSK KLMEMPVGTP KEDLKNTLRA 490 500 510 520 530 540 SVFLVRRAIK DIVTSVFQAS LKLLKMIITQ YIPKHKLSKL ETAHCVERTI PVLLTRTGDS 550 560 570 580 590 600 SARLRVTAAN FIQEMALFKE VKSLQIIPSY LVQPLKANSS VHLAMSQMGL LARLLKDLGT 610 620 630 640 650 660 GSSGFTIDNV MKFSVSALEH RVYEVRETAV RIILDMYRQH QASILEYLPP DDSNTRRNIL 670 680 690 700 710 720 YKTIFEGFAK IDGRATDAEM RARRKAATEE AEKQKKEEIK ALQGQLAALK EIQAEVQEKE 730 740 750 760 770 780 SDAVKPKNQD IQGGKAAPAE ALGIPDEHYL DNLCIFCGER SESFTEEGLD LHYWKHCLML 790 800 810 820 830 840 TRCDHCKQVV EISSLTEHLL TECDKKDGFG KCYRCSEAVF KEELPRHIKH KDCNPAKPEK 850 860 870 880 890 900 LANRCPLCHE NFSPGEEAWK AHLMGPAGCT MNLRKTHILQ KAPALQPGKS SAVAASGPLG 910 920 SKAGSKIPTP KGGLSKSSSR TYAKR
	Isoform 2 [UniParc]. Checksum: 91F314638FBB292C	FASTA	244	27,350
	10 20 30 40 50 60 MPHKIGFVVV SSSGHEDGFS ARELMIHAPT VSGWRSPRFC QFPQEIVLQM VERCRIRKLQ 70 80 90 100 110 120 LLAHQYMISS KIEFYISESL PEYFAPYQAE RFRRLGYVSL CDNEKTGCKA RELKSVYVDA 130 140 150 160 170 180 VGQFLKLIFH QNHVNKYNIY NQVALVAINI IGDPADFSDE SNTASREKLI DHYLGHNSED 190 200 210 220 230 240 PALEGTYASS VRTGGESTFG ELKGPAVPSS VTLSVLGTSL GQWFPCHLPA VDDNEGTPFQ RCLV
	Isoform 3 [UniParc]. Checksum: 45407773F3D60E53	FASTA	554	63,187
	10 20 30 40 50 60 MPHKIGFVVV SSSGHEDGFS ARELMIHAPT VSGWRSPRFC QFPQEIVLQM VERCRIRKLQ 70 80 90 100 110 120 LLAHQYMISS KIEFYISESL PEYFAPYQAE RFRRLGYVSL CDNEKTGCKA RELKSVYVDA 130 140 150 160 170 180 VGQFLKLIFH QNHVNKYNIY NQVALVAINI IGDPADFSDE SNTASREKLI DHYLGHNSED 190 200 210 220 230 240 PALEGTYARK SDYISPLDDL AFDMYQDPEV AQIIRKLDER KREAVQKERY DYAKKLKQAI 250 260 270 280 290 300 ADLQKVGERL GRYEVEKRCA VEKEDYDLAK EKKQQMEQYR AEVYEQLELH SLLDAELMRR 310 320 330 340 350 360 PFDLPLQPLA RSGSPCHQKP MPSLPQLEER GTENQFAEPF LQEKPSSYSL TISPQHSAVD 370 380 390 400 410 420 PLLPATDPHP KINAESLPYD ERPLPAIRKH YGEAVVEPEM SNADISDARR GGMLGEPEPL 430 440 450 460 470 480 TEKALREASS AIDVLGETLV AEAYCKTWSY REDALLALSK KLMEMPVGTP KEDLKNTLRA 490 500 510 520 530 540 SVFLVRRAIK DIVTSVFQAS LKLLKMIITQ YIPKHKLSKL ETAHCVERTI PVLLTRTGDS 550 SARLRVTAAN FIQV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:31-39(1998) [PubMed: 9628581] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[2]	Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION TO N-TERMINUS.
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3). Tissue: Kidney, Skin and Testis.
[5]	"Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods." Jakobsen L., Vanselow K., Skogs M., Toyoda Y., Lundberg E., Poser I., Falkenby L.G., Bennetzen M., Westendorf J., Nigg E.A., Uhlen M., Hyman A.A., Andersen J.S. EMBO J. 30:1520-1535(2011) [PubMed: 21399614] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB011134 mRNA. Translation: BAA25488.2. Different initiation. AL691523 Genomic DNA. Translation: CAI17368.1. AL691523, AL365330 Genomic DNA. Translation: CAI17369.1. AL365330, AL691523 Genomic DNA. Translation: CAI42527.1. AL365330 Genomic DNA. Translation: CAI42529.1. BC001640 mRNA. Translation: AAH01640.1. Sequence problems. BC047450 mRNA. Translation: AAH47450.1. BC050721 mRNA. Translation: AAH50721.1.
IPI	IPI00006014. IPI00384358. IPI00607758.
PIR	T00334.
RefSeq	NP_055519.1. NM_014704.3.
UniGene	Hs.133089. Hs.509017.
3D structure databases
ProteinModelPortal	O60308.
SMR	O60308. Positions 767-834.
ModBase	Search...
Protein-protein interaction databases
IntAct	O60308. 1 interaction.
PTM databases
PhosphoSite	O60308.
Proteomic databases
PRIDE	O60308.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000378230; ENSP00000367476; ENSG00000116198.
GeneID	9731.
KEGG	hsa:9731.
UCSC	uc001aky.1. human. uc001akz.2. human.
Organism-specific databases
CTD	9731.
GeneCards	GC01M003728.
HGNC	HGNC:24866. CEP104.
HPA	HPA010126.
neXtProt	NX_O60308.
PharmGKB	PA144596418.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG14085.
GeneTree	ENSGT00390000013405.
HOVERGEN	HBG080375.
InParanoid	O60308.
OMA	YEQLELH.
OrthoDB	EOG4TXBRF.
PhylomeDB	O60308.
Gene expression databases
ArrayExpress	O60308.
Bgee	O60308.
CleanEx	HS_KIAA0562.
Genevestigator	O60308.
GermOnline	ENSG00000116198. Homo sapiens.
Family and domain databases
InterPro	IPR011989. ARM-like. IPR016024. ARM-type_fold. IPR008979. Galactose-bd-like. [Graphical view]
Gene3D	G3DSA:1.25.10.10. ARM-like. 1 hit.
SUPFAM	SSF48371. ARM-type_fold. 1 hit. SSF49785. Gal_bind_like. 1 hit.
PROSITE	PS50077. HEAT_REPEAT. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	36608.

Entry information

Entry name

CE104_HUMAN

Accession

Primary (citable) accession number: O60308
Secondary accession number(s): Q5JSQ3 , Q5SR24, Q5SR25, Q6PKF5, Q86W32, Q86X14

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	August 1, 1998
Last modified:	January 25, 2012
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.