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Protein

Intron-binding protein aquarius

Gene

AQR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing.1 Publication

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  • mRNA splicing, via spliceosome Source: UniProtKB
  • transcription-coupled nucleotide-excision repair Source: Reactome
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000021776-MONOMER.
ReactomeiR-HSA-6781823. Formation of TC-NER Pre-Incision Complex.
R-HSA-6781827. Transcription-Coupled Nucleotide Excision Repair (TC-NER).
R-HSA-6782135. Dual incision in TC-NER.
R-HSA-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-HSA-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Intron-binding protein aquarius
Alternative name(s):
Intron-binding protein of 160 kDa
Short name:
IBP160
Gene namesi
Name:AQR
Synonyms:KIAA0560
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:29513. AQR.

Subcellular locationi

  • Nucleus 1 Publication

  • Note: Localizes to speckle-like regions of the nucleoplasm.1 Publication

GO - Cellular componenti

  • catalytic step 2 spliceosome Source: UniProtKB
  • membrane Source: UniProtKB
  • nucleoplasm Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi9716.
OpenTargetsiENSG00000021776.
PharmGKBiPA134869224.

Polymorphism and mutation databases

BioMutaiAQR.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002523891 – 1485Intron-binding protein aquariusAdd BLAST1485

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1051N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO60306.
MaxQBiO60306.
PaxDbiO60306.
PeptideAtlasiO60306.
PRIDEiO60306.

PTM databases

iPTMnetiO60306.
PhosphoSitePlusiO60306.

Expressioni

Gene expression databases

BgeeiENSG00000021776.
CleanExiHS_AQR.
ExpressionAtlasiO60306. baseline and differential.
GenevisibleiO60306. HS.

Interactioni

Subunit structurei

Identified in the spliceosome C complex. Component of the XAB2 complex, a multimeric protein complex composed of XAB2, PRPF19, AQR, ZNF830, ISY1, and PPIE.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ZNF830Q96NB32EBI-2512328,EBI-3920997

Protein-protein interaction databases

BioGridi115065. 56 interactors.
DIPiDIP-53576N.
IntActiO60306. 23 interactors.
MINTiMINT-5005864.
STRINGi9606.ENSP00000156471.

Structurei

Secondary structure

11485
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi20 – 30Combined sources11
Helixi43 – 52Combined sources10
Turni53 – 58Combined sources6
Helixi61 – 69Combined sources9
Helixi72 – 75Combined sources4
Helixi78 – 80Combined sources3
Turni83 – 85Combined sources3
Helixi88 – 103Combined sources16
Helixi110 – 114Combined sources5
Helixi119 – 131Combined sources13
Beta strandi136 – 138Combined sources3
Helixi140 – 154Combined sources15
Turni155 – 158Combined sources4
Helixi160 – 170Combined sources11
Helixi172 – 177Combined sources6
Helixi180 – 189Combined sources10
Helixi193 – 205Combined sources13
Helixi209 – 219Combined sources11
Helixi221 – 234Combined sources14
Beta strandi238 – 240Combined sources3
Helixi244 – 261Combined sources18
Helixi264 – 276Combined sources13
Helixi279 – 284Combined sources6
Helixi287 – 290Combined sources4
Turni292 – 295Combined sources4
Helixi296 – 309Combined sources14
Turni315 – 317Combined sources3
Helixi323 – 344Combined sources22
Helixi346 – 348Combined sources3
Helixi349 – 353Combined sources5
Helixi356 – 359Combined sources4
Helixi362 – 369Combined sources8
Helixi374 – 383Combined sources10
Helixi400 – 411Combined sources12
Helixi417 – 422Combined sources6
Helixi430 – 433Combined sources4
Turni436 – 438Combined sources3
Beta strandi446 – 448Combined sources3
Helixi462 – 491Combined sources30
Beta strandi494 – 496Combined sources3
Beta strandi502 – 506Combined sources5
Beta strandi509 – 522Combined sources14
Beta strandi535 – 542Combined sources8
Helixi547 – 553Combined sources7
Beta strandi561 – 567Combined sources7
Helixi583 – 587Combined sources5
Beta strandi589 – 601Combined sources13
Beta strandi620 – 629Combined sources10
Helixi631 – 644Combined sources14
Helixi649 – 651Combined sources3
Beta strandi655 – 657Combined sources3
Helixi661 – 663Combined sources3
Helixi666 – 678Combined sources13
Helixi685 – 691Combined sources7
Turni697 – 700Combined sources4
Helixi702 – 704Combined sources3
Beta strandi710 – 715Combined sources6
Helixi721 – 727Combined sources7
Beta strandi731 – 736Combined sources6
Turni740 – 742Combined sources3
Beta strandi745 – 750Combined sources6
Beta strandi775 – 781Combined sources7
Helixi791 – 793Combined sources3
Helixi804 – 814Combined sources11
Beta strandi815 – 822Combined sources8
Helixi829 – 843Combined sources15
Beta strandi849 – 854Combined sources6
Helixi856 – 866Combined sources11
Helixi873 – 875Combined sources3
Beta strandi876 – 878Combined sources3
Beta strandi888 – 890Combined sources3
Helixi894 – 918Combined sources25
Helixi929 – 938Combined sources10
Helixi940 – 951Combined sources12
Helixi961 – 966Combined sources6
Turni969 – 976Combined sources8
Beta strandi977 – 979Combined sources3
Helixi987 – 1011Combined sources25
Helixi1013 – 1016Combined sources4
Helixi1020 – 1029Combined sources10
Beta strandi1033 – 1038Combined sources6
Helixi1039 – 1052Combined sources14
Beta strandi1057 – 1063Combined sources7
Helixi1064 – 1066Combined sources3
Helixi1069 – 1073Combined sources5
Helixi1074 – 1077Combined sources4
Beta strandi1090 – 1095Combined sources6
Helixi1108 – 1113Combined sources6
Helixi1119 – 1126Combined sources8
Helixi1141 – 1148Combined sources8
Beta strandi1151 – 1153Combined sources3
Helixi1158 – 1162Combined sources5
Helixi1164 – 1166Combined sources3
Beta strandi1173 – 1181Combined sources9
Beta strandi1188 – 1191Combined sources4
Helixi1201 – 1217Combined sources17
Helixi1221 – 1223Combined sources3
Beta strandi1224 – 1229Combined sources6
Helixi1231 – 1244Combined sources14
Beta strandi1257 – 1259Combined sources3
Helixi1260 – 1263Combined sources4
Beta strandi1268 – 1274Combined sources7
Helixi1282 – 1285Combined sources4
Helixi1287 – 1293Combined sources7
Beta strandi1296 – 1305Combined sources10
Helixi1307 – 1311Combined sources5
Helixi1314 – 1316Combined sources3
Helixi1317 – 1323Combined sources7
Beta strandi1328 – 1332Combined sources5
Beta strandi1343 – 1346Combined sources4
Beta strandi1353 – 1355Combined sources3
Helixi1358 – 1375Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4PJ3X-ray2.30A19-1485[»]
ProteinModelPortaliO60306.
SMRiO60306.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CWF11 family.Curated

Phylogenomic databases

eggNOGiKOG1806. Eukaryota.
ENOG410XPV8. LUCA.
GeneTreeiENSGT00810000125415.
HOGENOMiHOG000170551.
HOVERGENiHBG080430.
InParanoidiO60306.
KOiK12874.
OMAiIIWDENV.
OrthoDBiEOG091G09WT.
PhylomeDBiO60306.
TreeFamiTF105711.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR032464. Aquarius.
IPR032174. Aquarius_N.
IPR026300. CWF11_fam.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10887:SF5. PTHR10887:SF5. 1 hit.
PfamiPF16399. Aquarius_N. 1 hit.
[Graphical view]
PIRSFiPIRSF038901. AQR_cwf11. 1 hit.
SUPFAMiSSF52540. SSF52540. 3 hits.

Sequencei

Sequence statusi: Complete.

O60306-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPAQPKKI VAPTVSQINA EFVTQLACKY WAPHIKKKSP FDIKVIEDIY
60 70 80 90 100
EKEIVKSRFA IRKIMLLEFS QYLENYLWMN YSPEVSSKAY LMSICCMVNE
110 120 130 140 150
KFRENVPAWE IFKKKPDHFP FFFKHILKAA LAETDGEFSL HEQTVLLLFL
160 170 180 190 200
DHCFNSLEVD LIRSQVQQLI SLPMWMGLQL ARLELELKKT PKLRKFWNLI
210 220 230 240 250
KKNDEKMDPE AREQAYQERR FLSQLIQKFI SVLKSVPLSE PVTMDKVHYC
260 270 280 290 300
ERFIELMIDL EALLPTRRWF NTILDDSHLL VHCYLSNLVR REEDGHLFSQ
310 320 330 340 350
LLDMLKFYTG FEINDQTGNA LTENEMTTIH YDRITSLQRA AFAHFPELYD
360 370 380 390 400
FALSNVAEVD TRESLVKFFG PLSSNTLHQV ASYLCLLPTL PKNEDTTFDK
410 420 430 440 450
EFLLELLVSR HERRISQIQQ LNQMPLYPTE KIIWDENIVP TEYYSGEGCL
460 470 480 490 500
ALPKLNLQFL TLHDYLLRNF NLFRLESTYE IRQDIEDSVS RMKPWQSEYG
510 520 530 540 550
GVVFGGWARM AQPIVAFTVV EVAKPNIGEN WPTRVRADVT INLNVRDHIK
560 570 580 590 600
DEWEGLRKHD VCFLITVRPT KPYGTKFDRR RPFIEQVGLV YVRGCEIQGM
610 620 630 640 650
LDDKGRVIED GPEPRPNLRG ESRTFRVFLD PNQYQQDMTN TIQNGAEDVY
660 670 680 690 700
ETFNIIMRRK PKENNFKAVL ETIRNLMNTD CVVPDWLHDI ILGYGDPSSA
710 720 730 740 750
HYSKMPNQIA TLDFNDTFLS IEHLKASFPG HNVKVTVEDP ALQIPPFRIT
760 770 780 790 800
FPVRSGKGKK RKDADVEDED TEEAKTLIVE PHVIPNRGPY PYNQPKRNTI
810 820 830 840 850
QFTHTQIEAI RAGMQPGLTM VVGPPGTGKT DVAVQIISNI YHNFPEQRTL
860 870 880 890 900
IVTHSNQALN QLFEKIMALD IDERHLLRLG HGEEELETEK DFSRYGRVNY
910 920 930 940 950
VLARRIELLE EVKRLQKSLG VPGDASYTCE TAGYFFLYQV MSRWEEYISK
960 970 980 990 1000
VKNKGSTLPD VTEVSTFFPF HEYFANAPQP IFKGRSYEED MEIAEGCFRH
1010 1020 1030 1040 1050
IKKIFTQLEE FRASELLRSG LDRSKYLLVK EAKIIAMTCT HAALKRHDLV
1060 1070 1080 1090 1100
KLGFKYDNIL MEEAAQILEI ETFIPLLLQN PQDGFSRLKR WIMIGDHHQL
1110 1120 1130 1140 1150
PPVIKNMAFQ KYSNMEQSLF TRFVRVGVPT VDLDAQGRAR ASLCNLYNWR
1160 1170 1180 1190 1200
YKNLGNLPHV QLLPEFSTAN AGLLYDFQLI NVEDFQGVGE SEPNPYFYQN
1210 1220 1230 1240 1250
LGEAEYVVAL FMYMCLLGYP ADKISILTTY NGQKHLIRDI INRRCGNNPL
1260 1270 1280 1290 1300
IGRPNKVTTV DRFQGQQNDY ILLSLVRTRA VGHLRDVRRL VVAMSRARLG
1310 1320 1330 1340 1350
LYIFARVSLF QNCFELTPAF SQLTARPLHL HIIPTEPFPT TRKNGERPSH
1360 1370 1380 1390 1400
EVQIIKNMPQ MANFVYNMYM HLIQTTHHYH QTLLQLPPAM VEEGEEVQNQ
1410 1420 1430 1440 1450
ETELETEEEA MTVQADIIPS PTDTSCRQET PAFQTDTTPS ETGATSTPEA
1460 1470 1480
IPALSETTPT VVGAVSAPAE ANTPQDATSA PEETK
Length:1,485
Mass (Da):171,295
Last modified:October 17, 2006 - v4
Checksum:iD0ADDA621A9418FD
GO

Sequence cautioni

The sequence BAA25486 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti242V → A in ABQ66265 (PubMed:17974005).Curated1
Sequence conflicti1026Y → F in ABQ66265 (PubMed:17974005).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011132 mRNA. Translation: BAA25486.3. Different initiation.
EF553519 mRNA. Translation: ABQ66265.1.
BC036913 mRNA. Translation: AAH36913.1.
BC070379 mRNA. Translation: AAH70379.1.
BC108262 mRNA. Translation: AAI08263.1.
BC127111 mRNA. Translation: AAI27112.1.
BC127112 mRNA. Translation: AAI27113.1.
CCDSiCCDS42013.1.
PIRiT00333.
RefSeqiNP_055506.1. NM_014691.2.
UniGeneiHs.510958.

Genome annotation databases

EnsembliENST00000156471; ENSP00000156471; ENSG00000021776.
GeneIDi9716.
KEGGihsa:9716.
UCSCiuc001ziv.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011132 mRNA. Translation: BAA25486.3. Different initiation.
EF553519 mRNA. Translation: ABQ66265.1.
BC036913 mRNA. Translation: AAH36913.1.
BC070379 mRNA. Translation: AAH70379.1.
BC108262 mRNA. Translation: AAI08263.1.
BC127111 mRNA. Translation: AAI27112.1.
BC127112 mRNA. Translation: AAI27113.1.
CCDSiCCDS42013.1.
PIRiT00333.
RefSeqiNP_055506.1. NM_014691.2.
UniGeneiHs.510958.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4PJ3X-ray2.30A19-1485[»]
ProteinModelPortaliO60306.
SMRiO60306.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115065. 56 interactors.
DIPiDIP-53576N.
IntActiO60306. 23 interactors.
MINTiMINT-5005864.
STRINGi9606.ENSP00000156471.

PTM databases

iPTMnetiO60306.
PhosphoSitePlusiO60306.

Polymorphism and mutation databases

BioMutaiAQR.

Proteomic databases

EPDiO60306.
MaxQBiO60306.
PaxDbiO60306.
PeptideAtlasiO60306.
PRIDEiO60306.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000156471; ENSP00000156471; ENSG00000021776.
GeneIDi9716.
KEGGihsa:9716.
UCSCiuc001ziv.4. human.

Organism-specific databases

CTDi9716.
DisGeNETi9716.
GeneCardsiAQR.
HGNCiHGNC:29513. AQR.
MIMi610548. gene.
neXtProtiNX_O60306.
OpenTargetsiENSG00000021776.
PharmGKBiPA134869224.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1806. Eukaryota.
ENOG410XPV8. LUCA.
GeneTreeiENSGT00810000125415.
HOGENOMiHOG000170551.
HOVERGENiHBG080430.
InParanoidiO60306.
KOiK12874.
OMAiIIWDENV.
OrthoDBiEOG091G09WT.
PhylomeDBiO60306.
TreeFamiTF105711.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000021776-MONOMER.
ReactomeiR-HSA-6781823. Formation of TC-NER Pre-Incision Complex.
R-HSA-6781827. Transcription-Coupled Nucleotide Excision Repair (TC-NER).
R-HSA-6782135. Dual incision in TC-NER.
R-HSA-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-HSA-72163. mRNA Splicing - Major Pathway.

Miscellaneous databases

ChiTaRSiAQR. human.
GenomeRNAii9716.
PROiO60306.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000021776.
CleanExiHS_AQR.
ExpressionAtlasiO60306. baseline and differential.
GenevisibleiO60306. HS.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR032464. Aquarius.
IPR032174. Aquarius_N.
IPR026300. CWF11_fam.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10887:SF5. PTHR10887:SF5. 1 hit.
PfamiPF16399. Aquarius_N. 1 hit.
[Graphical view]
PIRSFiPIRSF038901. AQR_cwf11. 1 hit.
SUPFAMiSSF52540. SSF52540. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiAQR_HUMAN
AccessioniPrimary (citable) accession number: O60306
Secondary accession number(s): A0JP17
, A5YKK3, Q2YDX9, Q6IRU8, Q6PIC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 17, 2006
Last modified: November 2, 2016
This is version 121 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.