O60299 (PRIP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ProSAP-interacting protein 1
Short name=ProSAPiP1

Gene names

Name:	PROSAPIP1
Synonyms:	KIAA0552

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	673 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subunit structure	Interacts (via C-terminus) with SHANK3 (via PDZ domain). Interacts (via coiled coil) with SIPA1L1. Can form homooligomers By similarity.
Subcellular location	Cell junction › synapse › postsynaptic cell membrane › postsynaptic density By similarity. Cytoplasm › cytoskeleton By similarity. Note: Detected at synapses, postsynaptic density, synaptic spines and dendrites By similarity.
Sequence similarities	Belongs to the PROSAPIP1 family.
Sequence caution	The sequence BAA25478.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cell junction Cell membrane Cytoplasm Cytoskeleton Membrane Postsynaptic cell membrane Synapse
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW postsynaptic density Inferred from sequence or structural similarity. Source: UniProtKB postsynaptic membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O60299-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O60299-2)

The sequence of this isoform differs from the canonical sequence as follows:
     351-396: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 673	673	ProSAP-interacting protein 1		PRO_0000050760
Regions
	Coiled coil	317 – 496	180	Potential
	Coiled coil	571 – 639	69	Potential
	Compositional bias	60 – 63	4	Poly-Gly
	Compositional bias	122 – 125	4	Poly-Ser
	Compositional bias	282 – 290	9	Poly-Ser
	Compositional bias	298 – 306	9	Poly-Gly
	Compositional bias	550 – 553	4	Poly-Ala
Natural variations
	Alternative sequence	351 – 396	46	Missing in isoform 2.		VSP_039202
Experimental info
	Sequence conflict	557	1	S → Y in AAH38860. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 3E548EC03A01F770	FASTA	673	71,791
	10 20 30 40 50 60 MAKLETLPVR ADPGRDPLLA FAPRPSELGP PDPRLAMGSV GSGVAHAQEF AMKSVGTRTG 70 80 90 100 110 120 GGGSQGSFPG PRGSGSGASR ERPGRYPSED KGLANSLYLN GELRGSDHTD VCGNVVGSSG 130 140 150 160 170 180 GSSSSGGSDK APPQYREPSH PPKLLATSGK LDQCSEPLVR PSAFKPVVPK NFHSMQNLCP 190 200 210 220 230 240 PQTNGTPEGR QGPGGLKGGL DKSRTMTPAG GSGSGLSDSG RNSLTSLPTY SSSYSQHLAP 250 260 270 280 290 300 LSASTSHINR IGTASYGSGS GGSSGGGSGY QDLGTSDSGR ASSKSGSSSS MGRPGHLGSG 310 320 330 340 350 360 EGGGGGLPFA ACSPPSPSAL IQELEERLWE KEQEVAALRR SLEQSEAAVA QVLEERQKAW 370 380 390 400 410 420 ERELAELRQG CSGKLQQVAR RAQRAQQGLQ LQVLRLQQDK KQLQEEAARL MRQREELEDK 430 440 450 460 470 480 VAACQKEQAD FLPRIEETKW EVCQKAGEIS LLKQQLKDSQ ADVSQKLSEI VGLRSQLREG 490 500 510 520 530 540 RASLREKEEQ LLSLRDSFSS KQASLELGEG ELPAACLKPA LTPVDPAEPQ DALATCESDE 550 560 570 580 590 600 AKMRRQAGVA AAASLVSVDG EAEAGGESGT RALRREVGRL QAELAAERRA RERQGASFAE 610 620 630 640 650 660 ERRVWLEEKE KVIEYQKQLQ LSYVEMYQRN QQLERRLRER GAAGGASTPT PQHGEEKKAW 670 TPSRLERIES TEI
	Isoform 2 [UniParc]. Checksum: 5747A212FD997D81	FASTA	627	66,409
	10 20 30 40 50 60 MAKLETLPVR ADPGRDPLLA FAPRPSELGP PDPRLAMGSV GSGVAHAQEF AMKSVGTRTG 70 80 90 100 110 120 GGGSQGSFPG PRGSGSGASR ERPGRYPSED KGLANSLYLN GELRGSDHTD VCGNVVGSSG 130 140 150 160 170 180 GSSSSGGSDK APPQYREPSH PPKLLATSGK LDQCSEPLVR PSAFKPVVPK NFHSMQNLCP 190 200 210 220 230 240 PQTNGTPEGR QGPGGLKGGL DKSRTMTPAG GSGSGLSDSG RNSLTSLPTY SSSYSQHLAP 250 260 270 280 290 300 LSASTSHINR IGTASYGSGS GGSSGGGSGY QDLGTSDSGR ASSKSGSSSS MGRPGHLGSG 310 320 330 340 350 360 EGGGGGLPFA ACSPPSPSAL IQELEERLWE KEQEVAALRR SLEQSEAAVA QQDKKQLQEE 370 380 390 400 410 420 AARLMRQREE LEDKVAACQK EQADFLPRIE ETKWEVCQKA GEISLLKQQL KDSQADVSQK 430 440 450 460 470 480 LSEIVGLRSQ LREGRASLRE KEEQLLSLRD SFSSKQASLE LGEGELPAAC LKPALTPVDP 490 500 510 520 530 540 AEPQDALATC ESDEAKMRRQ AGVAAAASLV SVDGEAEAGG ESGTRALRRE VGRLQAELAA 550 560 570 580 590 600 ERRARERQGA SFAEERRVWL EEKEKVIEYQ KQLQLSYVEM YQRNQQLERR LRERGAAGGA 610 620 STPTPQHGEE KKAWTPSRLE RIESTEI

References

[1]	"Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[2]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB011124 mRNA. Translation: BAA25478.2. Different initiation. AL121891 Genomic DNA. Translation: CAC09910.1. AL121891 Genomic DNA. Translation: CAM27675.1. CH471133 Genomic DNA. Translation: EAX10545.1. CH471133 Genomic DNA. Translation: EAX10546.1. CH471133 Genomic DNA. Translation: EAX10547.1. BC038860 mRNA. Translation: AAH38860.1.
IPI	IPI00028588. IPI00332777.
PIR	T00328.
RefSeq	NP_055546.1. NM_014731.2.
UniGene	Hs.90232.
3D structure databases
ProteinModelPortal	O60299.
SMR	O60299. Positions 321-351.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000332123.
PTM databases
PhosphoSite	O60299.
Proteomic databases
PaxDb	O60299.
PRIDE	O60299.
Protocols and materials databases
DNASU	9762.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	9762.
KEGG	hsa:9762.
UCSC	uc002wia.1. human. uc002wib.1. human.
Organism-specific databases
CTD	9762.
GeneCards	GC20M003145.
H-InvDB	HIX0015590.
HPA	HPA031008. HPA031009.
MIM	610484. gene.
neXtProt	NX_O60299.
HUGE	Search...
Phylogenomic databases
eggNOG	NOG137465.
HOGENOM	HOG000230889.
HOVERGEN	HBG052381.
InParanoid	O60299.
OMA	NYVEMYQ.
OrthoDB	EOG4G1MGH.
PhylomeDB	O60299.
Gene expression databases
Bgee	O60299.
Genevestigator	O60299.
GermOnline	ENSG00000088899. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
ChiTaRS	ProSAPiP1. human.
GenomeRNAi	9762.
NextBio	36745.
SOURCE	Search...

Entry information

Entry name

PRIP1_HUMAN

Accession

Primary (citable) accession number: O60299
Secondary accession number(s): A2A2Q7, D3DVX6, Q8IXX8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	August 1, 1998
Last modified:	May 1, 2013
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.