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O60299 (LZTS3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine zipper putative tumor suppressor 3
Alternative name(s):
ProSAP-interacting protein 1
Short name=ProSAPiP1
Gene names
Name:LZTS3
Synonyms:KIAA0552, PROSAPIP1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length673 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subunit structure

Interacts (via C-terminus) with SHANK3 (via PDZ domain). Interacts (via coiled coil) with SIPA1L1. Can form homooligomers By similarity.

Subcellular location

Cell junctionsynapsepostsynaptic cell membranepostsynaptic density By similarity. Cytoplasmcytoskeleton By similarity. Note: Detected at synapses, postsynaptic density, synaptic spines and dendrites By similarity.

Sequence similarities

Belongs to the LZTS3 family.

Sequence caution

The sequence BAA25478.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O60299-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O60299-2)

The sequence of this isoform differs from the canonical sequence as follows:
     351-396: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 673673Leucine zipper putative tumor suppressor 3
PRO_0000050760

Regions

Coiled coil317 – 496180 Potential
Coiled coil571 – 63969 Potential
Compositional bias60 – 634Poly-Gly
Compositional bias122 – 1254Poly-Ser
Compositional bias282 – 2909Poly-Ser
Compositional bias298 – 3069Poly-Gly
Compositional bias550 – 5534Poly-Ala

Natural variations

Alternative sequence351 – 39646Missing in isoform 2.
VSP_039202

Experimental info

Sequence conflict5571S → Y in AAH38860. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 3E548EC03A01F770

FASTA67371,791
        10         20         30         40         50         60 
MAKLETLPVR ADPGRDPLLA FAPRPSELGP PDPRLAMGSV GSGVAHAQEF AMKSVGTRTG 

        70         80         90        100        110        120 
GGGSQGSFPG PRGSGSGASR ERPGRYPSED KGLANSLYLN GELRGSDHTD VCGNVVGSSG 

       130        140        150        160        170        180 
GSSSSGGSDK APPQYREPSH PPKLLATSGK LDQCSEPLVR PSAFKPVVPK NFHSMQNLCP 

       190        200        210        220        230        240 
PQTNGTPEGR QGPGGLKGGL DKSRTMTPAG GSGSGLSDSG RNSLTSLPTY SSSYSQHLAP 

       250        260        270        280        290        300 
LSASTSHINR IGTASYGSGS GGSSGGGSGY QDLGTSDSGR ASSKSGSSSS MGRPGHLGSG 

       310        320        330        340        350        360 
EGGGGGLPFA ACSPPSPSAL IQELEERLWE KEQEVAALRR SLEQSEAAVA QVLEERQKAW 

       370        380        390        400        410        420 
ERELAELRQG CSGKLQQVAR RAQRAQQGLQ LQVLRLQQDK KQLQEEAARL MRQREELEDK 

       430        440        450        460        470        480 
VAACQKEQAD FLPRIEETKW EVCQKAGEIS LLKQQLKDSQ ADVSQKLSEI VGLRSQLREG 

       490        500        510        520        530        540 
RASLREKEEQ LLSLRDSFSS KQASLELGEG ELPAACLKPA LTPVDPAEPQ DALATCESDE 

       550        560        570        580        590        600 
AKMRRQAGVA AAASLVSVDG EAEAGGESGT RALRREVGRL QAELAAERRA RERQGASFAE 

       610        620        630        640        650        660 
ERRVWLEEKE KVIEYQKQLQ LSYVEMYQRN QQLERRLRER GAAGGASTPT PQHGEEKKAW 

       670 
TPSRLERIES TEI 

« Hide

Isoform 2 [UniParc].

Checksum: 5747A212FD997D81
Show »

FASTA62766,409

References

[1]"Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[2]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB011124 mRNA. Translation: BAA25478.2. Different initiation.
AL121891 Genomic DNA. Translation: CAC09910.1.
AL121891 Genomic DNA. Translation: CAM27675.1.
CH471133 Genomic DNA. Translation: EAX10545.1.
CH471133 Genomic DNA. Translation: EAX10546.1.
CH471133 Genomic DNA. Translation: EAX10547.1.
BC038860 mRNA. Translation: AAH38860.1.
PIRT00328.
RefSeqNP_001269462.1. NM_001282533.1.
XP_005260949.1. XM_005260892.1.
XP_005260950.1. XM_005260893.1.
UniGeneHs.90232.

3D structure databases

ProteinModelPortalO60299.
SMRO60299. Positions 320-351.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115109. 2 interactions.
IntActO60299. 1 interaction.
STRING9606.ENSP00000332123.

PTM databases

PhosphoSiteO60299.

Proteomic databases

PaxDbO60299.
PRIDEO60299.

Protocols and materials databases

DNASU9762.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID9762.
KEGGhsa:9762.
UCSCuc002wia.1. human. [O60299-1]
uc002wib.1. human. [O60299-2]

Organism-specific databases

CTD9762.
GeneCardsGC20M003146.
H-InvDBHIX0015590.
HPAHPA031008.
HPA031009.
MIM610484. gene.
neXtProtNX_O60299.
HUGESearch...

Phylogenomic databases

eggNOGNOG137465.
HOGENOMHOG000230889.
HOVERGENHBG052381.
InParanoidO60299.
OMANYVEMYQ.
OrthoDBEOG7F7W8K.
PhylomeDBO60299.

Gene expression databases

BgeeO60299.
GenevestigatorO60299.

Family and domain databases

ProtoNetSearch...

Other

ChiTaRSProSAPiP1. human.
GenomeRNAi9762.
NextBio36745.
SOURCESearch...

Entry information

Entry nameLZTS3_HUMAN
AccessionPrimary (citable) accession number: O60299
Secondary accession number(s): A2A2Q7, D3DVX6, Q8IXX8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: March 19, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM