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Protein

Leucine zipper putative tumor suppressor 3

Gene

LZTS3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000088899-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine zipper putative tumor suppressor 3Curated
Alternative name(s):
ProSAP-interacting protein 1By similarity
Short name:
ProSAPiP1By similarity
Gene namesi
Name:LZTS3Imported
Synonyms:KIAA0552Imported, PROSAPIP1By similarity
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:30139. LZTS3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000088899.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000507601 – 673Leucine zipper putative tumor suppressor 3Add BLAST673

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei316PhosphoserineBy similarity1
Modified residuei318PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO60299.
PaxDbiO60299.
PeptideAtlasiO60299.
PRIDEiO60299.

PTM databases

iPTMnetiO60299.
PhosphoSitePlusiO60299.

Expressioni

Gene expression databases

BgeeiENSG00000088899.
GenevisibleiO60299. HS.

Organism-specific databases

HPAiHPA031008.
HPA031009.

Interactioni

Subunit structurei

Interacts (via C-terminus) with SHANK3 (via PDZ domain). Interacts (via coiled coil) with SIPA1L1. Can form homooligomers (By similarity).By similarity

Protein-protein interaction databases

BioGridi115109. 6 interactors.
IntActiO60299. 5 interactors.
STRINGi9606.ENSP00000332123.

Structurei

3D structure databases

ProteinModelPortaliO60299.
SMRiO60299.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili317 – 496Sequence analysisAdd BLAST180
Coiled coili571 – 639Sequence analysisAdd BLAST69

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi60 – 63Poly-Gly4
Compositional biasi122 – 125Poly-Ser4
Compositional biasi282 – 290Poly-Ser9
Compositional biasi298 – 306Poly-Gly9
Compositional biasi550 – 553Poly-Ala4

Sequence similaritiesi

Belongs to the LZTS3 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFZY. Eukaryota.
ENOG410Z2V9. LUCA.
GeneTreeiENSGT00510000046769.
HOGENOMiHOG000230889.
HOVERGENiHBG052381.
InParanoidiO60299.
OMAiMQESRQR.
OrthoDBiEOG091G03L2.
PhylomeDBiO60299.

Family and domain databases

InterProiIPR033295. LZTS3.
[Graphical view]
PANTHERiPTHR19354:SF6. PTHR19354:SF6. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O60299-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKLETLPVR ADPGRDPLLA FAPRPSELGP PDPRLAMGSV GSGVAHAQEF
60 70 80 90 100
AMKSVGTRTG GGGSQGSFPG PRGSGSGASR ERPGRYPSED KGLANSLYLN
110 120 130 140 150
GELRGSDHTD VCGNVVGSSG GSSSSGGSDK APPQYREPSH PPKLLATSGK
160 170 180 190 200
LDQCSEPLVR PSAFKPVVPK NFHSMQNLCP PQTNGTPEGR QGPGGLKGGL
210 220 230 240 250
DKSRTMTPAG GSGSGLSDSG RNSLTSLPTY SSSYSQHLAP LSASTSHINR
260 270 280 290 300
IGTASYGSGS GGSSGGGSGY QDLGTSDSGR ASSKSGSSSS MGRPGHLGSG
310 320 330 340 350
EGGGGGLPFA ACSPPSPSAL IQELEERLWE KEQEVAALRR SLEQSEAAVA
360 370 380 390 400
QVLEERQKAW ERELAELRQG CSGKLQQVAR RAQRAQQGLQ LQVLRLQQDK
410 420 430 440 450
KQLQEEAARL MRQREELEDK VAACQKEQAD FLPRIEETKW EVCQKAGEIS
460 470 480 490 500
LLKQQLKDSQ ADVSQKLSEI VGLRSQLREG RASLREKEEQ LLSLRDSFSS
510 520 530 540 550
KQASLELGEG ELPAACLKPA LTPVDPAEPQ DALATCESDE AKMRRQAGVA
560 570 580 590 600
AAASLVSVDG EAEAGGESGT RALRREVGRL QAELAAERRA RERQGASFAE
610 620 630 640 650
ERRVWLEEKE KVIEYQKQLQ LSYVEMYQRN QQLERRLRER GAAGGASTPT
660 670
PQHGEEKKAW TPSRLERIES TEI
Length:673
Mass (Da):71,791
Last modified:August 1, 1998 - v1
Checksum:i3E548EC03A01F770
GO
Isoform 2 (identifier: O60299-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     351-396: Missing.

Show »
Length:627
Mass (Da):66,409
Checksum:i5747A212FD997D81
GO

Sequence cautioni

The sequence BAA25478 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti557S → Y in AAH38860 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_039202351 – 396Missing in isoform 2. 1 PublicationAdd BLAST46

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011124 mRNA. Translation: BAA25478.2. Different initiation.
AL121891 Genomic DNA. Translation: CAC09910.1.
AL121891 Genomic DNA. Translation: CAM27675.1.
CH471133 Genomic DNA. Translation: EAX10545.1.
CH471133 Genomic DNA. Translation: EAX10546.1.
CH471133 Genomic DNA. Translation: EAX10547.1.
BC038860 mRNA. Translation: AAH38860.1.
CCDSiCCDS63218.1. [O60299-2]
PIRiT00328.
RefSeqiNP_001269462.1. NM_001282533.1. [O60299-2]
XP_005260949.1. XM_005260892.1. [O60299-1]
XP_005260950.1. XM_005260893.2. [O60299-1]
UniGeneiHs.90232.

Genome annotation databases

EnsembliENST00000329152; ENSP00000332123; ENSG00000088899. [O60299-1]
ENST00000337576; ENSP00000338166; ENSG00000088899. [O60299-1]
ENST00000360342; ENSP00000353496; ENSG00000088899. [O60299-2]
GeneIDi9762.
KEGGihsa:9762.
UCSCiuc002wia.3. human. [O60299-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011124 mRNA. Translation: BAA25478.2. Different initiation.
AL121891 Genomic DNA. Translation: CAC09910.1.
AL121891 Genomic DNA. Translation: CAM27675.1.
CH471133 Genomic DNA. Translation: EAX10545.1.
CH471133 Genomic DNA. Translation: EAX10546.1.
CH471133 Genomic DNA. Translation: EAX10547.1.
BC038860 mRNA. Translation: AAH38860.1.
CCDSiCCDS63218.1. [O60299-2]
PIRiT00328.
RefSeqiNP_001269462.1. NM_001282533.1. [O60299-2]
XP_005260949.1. XM_005260892.1. [O60299-1]
XP_005260950.1. XM_005260893.2. [O60299-1]
UniGeneiHs.90232.

3D structure databases

ProteinModelPortaliO60299.
SMRiO60299.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115109. 6 interactors.
IntActiO60299. 5 interactors.
STRINGi9606.ENSP00000332123.

PTM databases

iPTMnetiO60299.
PhosphoSitePlusiO60299.

Proteomic databases

MaxQBiO60299.
PaxDbiO60299.
PeptideAtlasiO60299.
PRIDEiO60299.

Protocols and materials databases

DNASUi9762.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329152; ENSP00000332123; ENSG00000088899. [O60299-1]
ENST00000337576; ENSP00000338166; ENSG00000088899. [O60299-1]
ENST00000360342; ENSP00000353496; ENSG00000088899. [O60299-2]
GeneIDi9762.
KEGGihsa:9762.
UCSCiuc002wia.3. human. [O60299-1]

Organism-specific databases

CTDi9762.
GeneCardsiLZTS3.
H-InvDBHIX0015590.
HGNCiHGNC:30139. LZTS3.
HPAiHPA031008.
HPA031009.
MIMi610484. gene.
neXtProtiNX_O60299.
OpenTargetsiENSG00000088899.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFZY. Eukaryota.
ENOG410Z2V9. LUCA.
GeneTreeiENSGT00510000046769.
HOGENOMiHOG000230889.
HOVERGENiHBG052381.
InParanoidiO60299.
OMAiMQESRQR.
OrthoDBiEOG091G03L2.
PhylomeDBiO60299.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000088899-MONOMER.

Miscellaneous databases

GenomeRNAii9762.
PROiO60299.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000088899.
GenevisibleiO60299. HS.

Family and domain databases

InterProiIPR033295. LZTS3.
[Graphical view]
PANTHERiPTHR19354:SF6. PTHR19354:SF6. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLZTS3_HUMAN
AccessioniPrimary (citable) accession number: O60299
Secondary accession number(s): A2A2Q7, D3DVX6, Q8IXX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: November 30, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.