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O60299

- LZTS3_HUMAN

UniProt

O60299 - LZTS3_HUMAN

Protein

Leucine zipper putative tumor suppressor 3

Gene

LZTS3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine zipper putative tumor suppressor 3
    Alternative name(s):
    ProSAP-interacting protein 1
    Short name:
    ProSAPiP1
    Gene namesi
    Name:LZTS3
    Synonyms:KIAA0552, PROSAPIP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Subcellular locationi

    Cell junctionsynapsepostsynaptic cell membranepostsynaptic density By similarity. Cytoplasmcytoskeleton By similarity
    Note: Detected at synapses, postsynaptic density, synaptic spines and dendrites.By similarity

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. cytoplasm Source: UniProtKB-KW
    3. postsynaptic density Source: UniProtKB
    4. postsynaptic membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Postsynaptic cell membrane, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 673673Leucine zipper putative tumor suppressor 3PRO_0000050760Add
    BLAST

    Proteomic databases

    PaxDbiO60299.
    PRIDEiO60299.

    PTM databases

    PhosphoSiteiO60299.

    Expressioni

    Gene expression databases

    BgeeiO60299.
    GenevestigatoriO60299.

    Organism-specific databases

    HPAiHPA031008.
    HPA031009.

    Interactioni

    Subunit structurei

    Interacts (via C-terminus) with SHANK3 (via PDZ domain). Interacts (via coiled coil) with SIPA1L1. Can form homooligomers By similarity.By similarity

    Protein-protein interaction databases

    BioGridi115109. 3 interactions.
    IntActiO60299. 1 interaction.
    STRINGi9606.ENSP00000332123.

    Structurei

    3D structure databases

    ProteinModelPortaliO60299.
    SMRiO60299. Positions 320-351.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili317 – 496180Sequence AnalysisAdd
    BLAST
    Coiled coili571 – 63969Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi60 – 634Poly-Gly
    Compositional biasi122 – 1254Poly-Ser
    Compositional biasi282 – 2909Poly-Ser
    Compositional biasi298 – 3069Poly-Gly
    Compositional biasi550 – 5534Poly-Ala

    Sequence similaritiesi

    Belongs to the LZTS3 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG137465.
    HOGENOMiHOG000230889.
    HOVERGENiHBG052381.
    InParanoidiO60299.
    OMAiNYVEMYQ.
    OrthoDBiEOG7F7W8K.
    PhylomeDBiO60299.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O60299-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAKLETLPVR ADPGRDPLLA FAPRPSELGP PDPRLAMGSV GSGVAHAQEF    50
    AMKSVGTRTG GGGSQGSFPG PRGSGSGASR ERPGRYPSED KGLANSLYLN 100
    GELRGSDHTD VCGNVVGSSG GSSSSGGSDK APPQYREPSH PPKLLATSGK 150
    LDQCSEPLVR PSAFKPVVPK NFHSMQNLCP PQTNGTPEGR QGPGGLKGGL 200
    DKSRTMTPAG GSGSGLSDSG RNSLTSLPTY SSSYSQHLAP LSASTSHINR 250
    IGTASYGSGS GGSSGGGSGY QDLGTSDSGR ASSKSGSSSS MGRPGHLGSG 300
    EGGGGGLPFA ACSPPSPSAL IQELEERLWE KEQEVAALRR SLEQSEAAVA 350
    QVLEERQKAW ERELAELRQG CSGKLQQVAR RAQRAQQGLQ LQVLRLQQDK 400
    KQLQEEAARL MRQREELEDK VAACQKEQAD FLPRIEETKW EVCQKAGEIS 450
    LLKQQLKDSQ ADVSQKLSEI VGLRSQLREG RASLREKEEQ LLSLRDSFSS 500
    KQASLELGEG ELPAACLKPA LTPVDPAEPQ DALATCESDE AKMRRQAGVA 550
    AAASLVSVDG EAEAGGESGT RALRREVGRL QAELAAERRA RERQGASFAE 600
    ERRVWLEEKE KVIEYQKQLQ LSYVEMYQRN QQLERRLRER GAAGGASTPT 650
    PQHGEEKKAW TPSRLERIES TEI 673
    Length:673
    Mass (Da):71,791
    Last modified:August 1, 1998 - v1
    Checksum:i3E548EC03A01F770
    GO
    Isoform 2 (identifier: O60299-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         351-396: Missing.

    Show »
    Length:627
    Mass (Da):66,409
    Checksum:i5747A212FD997D81
    GO

    Sequence cautioni

    The sequence BAA25478.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti557 – 5571S → Y in AAH38860. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei351 – 39646Missing in isoform 2. 1 PublicationVSP_039202Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB011124 mRNA. Translation: BAA25478.2. Different initiation.
    AL121891 Genomic DNA. Translation: CAC09910.1.
    AL121891 Genomic DNA. Translation: CAM27675.1.
    CH471133 Genomic DNA. Translation: EAX10545.1.
    CH471133 Genomic DNA. Translation: EAX10546.1.
    CH471133 Genomic DNA. Translation: EAX10547.1.
    BC038860 mRNA. Translation: AAH38860.1.
    CCDSiCCDS63218.1. [O60299-2]
    PIRiT00328.
    RefSeqiNP_001269462.1. NM_001282533.1. [O60299-2]
    XP_005260949.1. XM_005260892.1. [O60299-1]
    XP_005260950.1. XM_005260893.1. [O60299-1]
    UniGeneiHs.90232.

    Genome annotation databases

    GeneIDi9762.
    KEGGihsa:9762.
    UCSCiuc002wia.1. human. [O60299-1]
    uc002wib.1. human. [O60299-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB011124 mRNA. Translation: BAA25478.2 . Different initiation.
    AL121891 Genomic DNA. Translation: CAC09910.1 .
    AL121891 Genomic DNA. Translation: CAM27675.1 .
    CH471133 Genomic DNA. Translation: EAX10545.1 .
    CH471133 Genomic DNA. Translation: EAX10546.1 .
    CH471133 Genomic DNA. Translation: EAX10547.1 .
    BC038860 mRNA. Translation: AAH38860.1 .
    CCDSi CCDS63218.1. [O60299-2 ]
    PIRi T00328.
    RefSeqi NP_001269462.1. NM_001282533.1. [O60299-2 ]
    XP_005260949.1. XM_005260892.1. [O60299-1 ]
    XP_005260950.1. XM_005260893.1. [O60299-1 ]
    UniGenei Hs.90232.

    3D structure databases

    ProteinModelPortali O60299.
    SMRi O60299. Positions 320-351.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115109. 3 interactions.
    IntActi O60299. 1 interaction.
    STRINGi 9606.ENSP00000332123.

    PTM databases

    PhosphoSitei O60299.

    Proteomic databases

    PaxDbi O60299.
    PRIDEi O60299.

    Protocols and materials databases

    DNASUi 9762.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 9762.
    KEGGi hsa:9762.
    UCSCi uc002wia.1. human. [O60299-1 ]
    uc002wib.1. human. [O60299-2 ]

    Organism-specific databases

    CTDi 9762.
    GeneCardsi GC20M003146.
    H-InvDB HIX0015590.
    HPAi HPA031008.
    HPA031009.
    MIMi 610484. gene.
    neXtProti NX_O60299.
    HUGEi Search...

    Phylogenomic databases

    eggNOGi NOG137465.
    HOGENOMi HOG000230889.
    HOVERGENi HBG052381.
    InParanoidi O60299.
    OMAi NYVEMYQ.
    OrthoDBi EOG7F7W8K.
    PhylomeDBi O60299.

    Miscellaneous databases

    ChiTaRSi ProSAPiP1. human.
    GenomeRNAii 9762.
    NextBioi 36745.
    SOURCEi Search...

    Gene expression databases

    Bgeei O60299.
    Genevestigatori O60299.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.

    Entry informationi

    Entry nameiLZTS3_HUMAN
    AccessioniPrimary (citable) accession number: O60299
    Secondary accession number(s): A2A2Q7, D3DVX6, Q8IXX8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3