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O60299

- LZTS3_HUMAN

UniProt

O60299 - LZTS3_HUMAN

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Protein
Leucine zipper putative tumor suppressor 3
Gene
LZTS3, KIAA0552, PROSAPIP1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine zipper putative tumor suppressor 3
Alternative name(s):
ProSAP-interacting protein 1
Short name:
ProSAPiP1
Gene namesi
Name:LZTS3
Synonyms:KIAA0552, PROSAPIP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Subcellular locationi

Cell junctionsynapsepostsynaptic cell membranepostsynaptic density By similarity. Cytoplasmcytoskeleton By similarity
Note: Detected at synapses, postsynaptic density, synaptic spines and dendrites By similarity.

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. cytoplasm Source: UniProtKB-KW
  3. postsynaptic density Source: UniProtKB
  4. postsynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 673673Leucine zipper putative tumor suppressor 3
PRO_0000050760Add
BLAST

Proteomic databases

PaxDbiO60299.
PRIDEiO60299.

PTM databases

PhosphoSiteiO60299.

Expressioni

Gene expression databases

BgeeiO60299.
GenevestigatoriO60299.

Organism-specific databases

HPAiHPA031008.
HPA031009.

Interactioni

Subunit structurei

Interacts (via C-terminus) with SHANK3 (via PDZ domain). Interacts (via coiled coil) with SIPA1L1. Can form homooligomers By similarity.

Protein-protein interaction databases

BioGridi115109. 3 interactions.
IntActiO60299. 1 interaction.
STRINGi9606.ENSP00000332123.

Structurei

3D structure databases

ProteinModelPortaliO60299.
SMRiO60299. Positions 320-351.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili317 – 496180 Reviewed prediction
Add
BLAST
Coiled coili571 – 63969 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi60 – 634Poly-Gly
Compositional biasi122 – 1254Poly-Ser
Compositional biasi282 – 2909Poly-Ser
Compositional biasi298 – 3069Poly-Gly
Compositional biasi550 – 5534Poly-Ala

Sequence similaritiesi

Belongs to the LZTS3 family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG137465.
HOGENOMiHOG000230889.
HOVERGENiHBG052381.
InParanoidiO60299.
OMAiNYVEMYQ.
OrthoDBiEOG7F7W8K.
PhylomeDBiO60299.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O60299-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAKLETLPVR ADPGRDPLLA FAPRPSELGP PDPRLAMGSV GSGVAHAQEF    50
AMKSVGTRTG GGGSQGSFPG PRGSGSGASR ERPGRYPSED KGLANSLYLN 100
GELRGSDHTD VCGNVVGSSG GSSSSGGSDK APPQYREPSH PPKLLATSGK 150
LDQCSEPLVR PSAFKPVVPK NFHSMQNLCP PQTNGTPEGR QGPGGLKGGL 200
DKSRTMTPAG GSGSGLSDSG RNSLTSLPTY SSSYSQHLAP LSASTSHINR 250
IGTASYGSGS GGSSGGGSGY QDLGTSDSGR ASSKSGSSSS MGRPGHLGSG 300
EGGGGGLPFA ACSPPSPSAL IQELEERLWE KEQEVAALRR SLEQSEAAVA 350
QVLEERQKAW ERELAELRQG CSGKLQQVAR RAQRAQQGLQ LQVLRLQQDK 400
KQLQEEAARL MRQREELEDK VAACQKEQAD FLPRIEETKW EVCQKAGEIS 450
LLKQQLKDSQ ADVSQKLSEI VGLRSQLREG RASLREKEEQ LLSLRDSFSS 500
KQASLELGEG ELPAACLKPA LTPVDPAEPQ DALATCESDE AKMRRQAGVA 550
AAASLVSVDG EAEAGGESGT RALRREVGRL QAELAAERRA RERQGASFAE 600
ERRVWLEEKE KVIEYQKQLQ LSYVEMYQRN QQLERRLRER GAAGGASTPT 650
PQHGEEKKAW TPSRLERIES TEI 673
Length:673
Mass (Da):71,791
Last modified:August 1, 1998 - v1
Checksum:i3E548EC03A01F770
GO
Isoform 2 (identifier: O60299-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     351-396: Missing.

Show »
Length:627
Mass (Da):66,409
Checksum:i5747A212FD997D81
GO

Sequence cautioni

The sequence BAA25478.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei351 – 39646Missing in isoform 2.
VSP_039202Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti557 – 5571S → Y in AAH38860. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB011124 mRNA. Translation: BAA25478.2. Different initiation.
AL121891 Genomic DNA. Translation: CAC09910.1.
AL121891 Genomic DNA. Translation: CAM27675.1.
CH471133 Genomic DNA. Translation: EAX10545.1.
CH471133 Genomic DNA. Translation: EAX10546.1.
CH471133 Genomic DNA. Translation: EAX10547.1.
BC038860 mRNA. Translation: AAH38860.1.
CCDSiCCDS63218.1. [O60299-2]
PIRiT00328.
RefSeqiNP_001269462.1. NM_001282533.1. [O60299-2]
XP_005260949.1. XM_005260892.1. [O60299-1]
XP_005260950.1. XM_005260893.1. [O60299-1]
UniGeneiHs.90232.

Genome annotation databases

GeneIDi9762.
KEGGihsa:9762.
UCSCiuc002wia.1. human. [O60299-1]
uc002wib.1. human. [O60299-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB011124 mRNA. Translation: BAA25478.2 . Different initiation.
AL121891 Genomic DNA. Translation: CAC09910.1 .
AL121891 Genomic DNA. Translation: CAM27675.1 .
CH471133 Genomic DNA. Translation: EAX10545.1 .
CH471133 Genomic DNA. Translation: EAX10546.1 .
CH471133 Genomic DNA. Translation: EAX10547.1 .
BC038860 mRNA. Translation: AAH38860.1 .
CCDSi CCDS63218.1. [O60299-2 ]
PIRi T00328.
RefSeqi NP_001269462.1. NM_001282533.1. [O60299-2 ]
XP_005260949.1. XM_005260892.1. [O60299-1 ]
XP_005260950.1. XM_005260893.1. [O60299-1 ]
UniGenei Hs.90232.

3D structure databases

ProteinModelPortali O60299.
SMRi O60299. Positions 320-351.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115109. 3 interactions.
IntActi O60299. 1 interaction.
STRINGi 9606.ENSP00000332123.

PTM databases

PhosphoSitei O60299.

Proteomic databases

PaxDbi O60299.
PRIDEi O60299.

Protocols and materials databases

DNASUi 9762.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 9762.
KEGGi hsa:9762.
UCSCi uc002wia.1. human. [O60299-1 ]
uc002wib.1. human. [O60299-2 ]

Organism-specific databases

CTDi 9762.
GeneCardsi GC20M003146.
H-InvDB HIX0015590.
HPAi HPA031008.
HPA031009.
MIMi 610484. gene.
neXtProti NX_O60299.
HUGEi Search...

Phylogenomic databases

eggNOGi NOG137465.
HOGENOMi HOG000230889.
HOVERGENi HBG052381.
InParanoidi O60299.
OMAi NYVEMYQ.
OrthoDBi EOG7F7W8K.
PhylomeDBi O60299.

Miscellaneous databases

ChiTaRSi ProSAPiP1. human.
GenomeRNAii 9762.
NextBioi 36745.
SOURCEi Search...

Gene expression databases

Bgeei O60299.
Genevestigatori O60299.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.

Entry informationi

Entry nameiLZTS3_HUMAN
AccessioniPrimary (citable) accession number: O60299
Secondary accession number(s): A2A2Q7, D3DVX6, Q8IXX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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