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O60296

- TRAK2_HUMAN

UniProt

O60296 - TRAK2_HUMAN

Protein

Trafficking kinesin-binding protein 2

Gene

TRAK2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 2 (25 Oct 2002)
      Previous versions | rss
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    Functioni

    May regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR.By similarity

    GO - Molecular functioni

    1. GABA receptor binding Source: HGNC
    2. protein binding Source: HGNC
    3. receptor binding Source: UniProtKB

    GO - Biological processi

    1. protein O-linked glycosylation Source: Ensembl
    2. protein targeting Source: Ensembl
    3. regulation of transcription from RNA polymerase II promoter Source: Ensembl

    Keywords - Biological processi

    Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Trafficking kinesin-binding protein 2
    Alternative name(s):
    Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein
    Gene namesi
    Name:TRAK2
    Synonyms:ALS2CR3, KIAA0549
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:13206. TRAK2.

    Subcellular locationi

    Cytoplasm By similarity. Early endosome By similarity. Mitochondrion By similarity
    Note: Colocalizes with MGARP at the mitochondria. Translocates from the cytoplasm to the mitochondria in a MGARP-dependent manner By similarity.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. early endosome Source: UniProtKB-SubCell
    3. mitochondrion Source: UniProtKB
    4. nucleus Source: Ensembl
    5. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Endosome, Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24744.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 914914Trafficking kinesin-binding protein 2PRO_0000064538Add
    BLAST

    Post-translational modificationi

    O-glycosylated.By similarity

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiO60296.
    PaxDbiO60296.
    PRIDEiO60296.

    PTM databases

    PhosphoSiteiO60296.

    Expressioni

    Tissue specificityi

    Widely expressed, with highest expression in heart.

    Gene expression databases

    ArrayExpressiO60296.
    BgeeiO60296.
    CleanExiHS_TRAK2.
    GenevestigatoriO60296.

    Organism-specific databases

    HPAiHPA015827.

    Interactioni

    Subunit structurei

    Interacts with GABA-A receptor and O-GlcNAc transferase. Interacts with HGS By similarity. Interacts with RHOT1/Miro-1 and RHOT2/Miro-2.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi122452. 4 interactions.
    IntActiO60296. 1 interaction.
    STRINGi9606.ENSP00000328875.

    Structurei

    3D structure databases

    ProteinModelPortaliO60296.
    SMRiO60296. Positions 259-297.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini48 – 353306HAP1 N-terminalAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni359 – 509151Interaction with HGSBy similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili134 – 354221Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 HAP1 N-terminal domain.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG246318.
    HOGENOMiHOG000143414.
    HOVERGENiHBG069248.
    InParanoidiO60296.
    KOiK15374.
    OMAiEETFRYM.
    OrthoDBiEOG7CRTSM.
    PhylomeDBiO60296.
    TreeFamiTF323495.

    Family and domain databases

    InterProiIPR006933. HAP1_N.
    IPR022154. Traffickng_kinesin-bd_prot_dom.
    [Graphical view]
    PfamiPF04849. HAP1_N. 1 hit.
    PF12448. Milton. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O60296-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSQSQNAIFT SPTGEENLMN SNHRDSESIT DVCSNEDLPE VELVSLLEEQ    50
    LPQYRLKVDT LFLYENQDWT QSPHQRQHAS DALSPVLAEE TFRYMILGTD 100
    RVEQMTKTYN DIDMVTHLLA ERDRDLELAA RIGQALLKRN HVLSEQNESL 150
    EEQLGQAFDQ VNQLQHELCK KDELLRIVSI ASEESETDSS CSTPLRFNES 200
    FSLSQGLLQL EMLQEKLKEL EEENMALRSK ACHIKTETVT YEEKEQQLVS 250
    DCVKELRETN AQMSRMTEEL SGKSDELIRY QEELSSLLSQ IVDLQHKLKE 300
    HVIEKEELKL HLQASKDAQR QLTMELHELQ DRNMECLGML HESQEEIKEL 350
    RSRSGPTAHL YFSQSYGAFT GESLAAEIEG TMRKKLSLDE ESSLFKQKAQ 400
    QKRVFDTVRI ANDTRGRSIS FPALLPIPGS NRSSVIMTAK PFESGLQQTE 450
    DKSLLNQGSS SEEVAGSSQK MGQPGPSGDS DLATALHRLS LRRQNYLSEK 500
    QFFAEEWQRK IQVLADQKEG VSGCVTPTES LASLCTTQSE ITDLSSASCL 550
    RGFMPEKLQI VKPLEGSQTL YHWQQLAQPN LGTILDPRPG VITKGFTQLP 600
    GDAIYHISDL EEDEEEGITF QVQQPLEVEE KLSTSKPVTG IFLPPITSAG 650
    GPVTVATANP GKCLSCTNST FTFTTCRILH PSDITQVTPS SGFPSLSCGS 700
    SGSSSSNTAV NSPALSYRLS IGESITNRRD STTTFSSTMS LAKLLQERGI 750
    SAKVYHSPIS ENPLQPLPKS LAIPSTPPNS PSHSPCPSPL PFEPRVHLSE 800
    NFLASRPAET FLQEMYGLRP SRNPPDVGQL KMNLVDRLKR LGIARVVKNP 850
    GAQENGRCQE AEIGPQKPDS AVYLNSGSSL LGGLRRNQSL PVIMGSFAAP 900
    VCTSSPKMGV LKED 914
    Length:914
    Mass (Da):101,419
    Last modified:October 25, 2002 - v2
    Checksum:iC26525C223A70D6D
    GO
    Isoform 2 (identifier: O60296-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         301-311: HVIEKEELKLH → VGLFIHSTDIC
         312-914: Missing.

    Show »
    Length:311
    Mass (Da):35,815
    Checksum:iBD6C40048A0FFEEB
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti142 – 1421V → I.2 Publications
    Corresponds to variant rs13022344 [ dbSNP | Ensembl ].
    VAR_014201
    Natural varianti528 – 5281T → I.1 Publication
    Corresponds to variant rs2244438 [ dbSNP | Ensembl ].
    VAR_014434
    Natural varianti863 – 8631I → N.1 Publication
    Corresponds to variant rs34594680 [ dbSNP | Ensembl ].
    VAR_051458

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei301 – 31111HVIEKEELKLH → VGLFIHSTDIC in isoform 2. 1 PublicationVSP_053418Add
    BLAST
    Alternative sequencei312 – 914603Missing in isoform 2. 1 PublicationVSP_053419Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB038964 Genomic DNA. Translation: BAB32550.1.
    AB038951 mRNA. Translation: BAB32501.1.
    AK054763 mRNA. Translation: BAB70803.1.
    AC007256 Genomic DNA. No translation available.
    AC007282 Genomic DNA. No translation available.
    AC080069 Genomic DNA. No translation available.
    AB011121 mRNA. Translation: BAA25475.1.
    BC017999 mRNA. Translation: AAH17999.1.
    CCDSiCCDS2347.1. [O60296-1]
    RefSeqiNP_055864.2. NM_015049.2. [O60296-1]
    UniGeneiHs.152774.

    Genome annotation databases

    EnsembliENST00000332624; ENSP00000328875; ENSG00000115993. [O60296-1]
    ENST00000430254; ENSP00000409333; ENSG00000115993. [O60296-2]
    GeneIDi66008.
    KEGGihsa:66008.
    UCSCiuc002uyb.4. human. [O60296-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB038964 Genomic DNA. Translation: BAB32550.1 .
    AB038951 mRNA. Translation: BAB32501.1 .
    AK054763 mRNA. Translation: BAB70803.1 .
    AC007256 Genomic DNA. No translation available.
    AC007282 Genomic DNA. No translation available.
    AC080069 Genomic DNA. No translation available.
    AB011121 mRNA. Translation: BAA25475.1 .
    BC017999 mRNA. Translation: AAH17999.1 .
    CCDSi CCDS2347.1. [O60296-1 ]
    RefSeqi NP_055864.2. NM_015049.2. [O60296-1 ]
    UniGenei Hs.152774.

    3D structure databases

    ProteinModelPortali O60296.
    SMRi O60296. Positions 259-297.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122452. 4 interactions.
    IntActi O60296. 1 interaction.
    STRINGi 9606.ENSP00000328875.

    PTM databases

    PhosphoSitei O60296.

    Proteomic databases

    MaxQBi O60296.
    PaxDbi O60296.
    PRIDEi O60296.

    Protocols and materials databases

    DNASUi 66008.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000332624 ; ENSP00000328875 ; ENSG00000115993 . [O60296-1 ]
    ENST00000430254 ; ENSP00000409333 ; ENSG00000115993 . [O60296-2 ]
    GeneIDi 66008.
    KEGGi hsa:66008.
    UCSCi uc002uyb.4. human. [O60296-1 ]

    Organism-specific databases

    CTDi 66008.
    GeneCardsi GC02M202241.
    H-InvDB HIX0002738.
    HGNCi HGNC:13206. TRAK2.
    HPAi HPA015827.
    MIMi 607334. gene.
    neXtProti NX_O60296.
    PharmGKBi PA24744.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG246318.
    HOGENOMi HOG000143414.
    HOVERGENi HBG069248.
    InParanoidi O60296.
    KOi K15374.
    OMAi EETFRYM.
    OrthoDBi EOG7CRTSM.
    PhylomeDBi O60296.
    TreeFami TF323495.

    Miscellaneous databases

    ChiTaRSi TRAK2. human.
    GeneWikii TRAK2.
    GenomeRNAii 66008.
    NextBioi 35500578.
    PROi O60296.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O60296.
    Bgeei O60296.
    CleanExi HS_TRAK2.
    Genevestigatori O60296.

    Family and domain databases

    InterProi IPR006933. HAP1_N.
    IPR022154. Traffickng_kinesin-bd_prot_dom.
    [Graphical view ]
    Pfami PF04849. HAP1_N. 1 hit.
    PF12448. Milton. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2."
      Hadano S., Yanagisawa Y., Skaug J., Fichter K., Nasir J., Martindale D., Koop B.F., Scherer S.W., Nicholson D.W., Rouleau G.A., Ikeda J.-E., Hayden M.R.
      Genomics 71:200-213(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS ILE-142 AND ILE-528.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ILE-142.
      Tissue: Cerebellum.
    3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 446-914 (ISOFORM 1).
      Tissue: Brain.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 798-914 (ISOFORM 1), VARIANT ASN-863.
      Tissue: Skin.
    6. "The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking."
      Fransson S., Ruusala A., Aspenstroem P.
      Biochem. Biophys. Res. Commun. 344:500-510(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RHOT1 AND RHOT2.

    Entry informationi

    Entry nameiTRAK2_HUMAN
    AccessioniPrimary (citable) accession number: O60296
    Secondary accession number(s): E7EV21
    , Q8WVH7, Q96NS2, Q9C0K5, Q9C0K6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: October 25, 2002
    Last modified: October 1, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3