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Protein

Zinc finger C3H1 domain-containing protein

Gene

ZFC3H1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1185 – 1206C3H1-typeAdd BLAST22

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000133858-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger C3H1 domain-containing protein
Alternative name(s):
Coiled-coil domain-containing protein 131
Proline/serine-rich coiled-coil protein 2
Gene namesi
Name:ZFC3H1
Synonyms:CCDC131, KIAA0546, PSRC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:28328. ZFC3H1.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi196441.
OpenTargetsiENSG00000133858.
PharmGKBiPA164727644.

Polymorphism and mutation databases

BioMutaiZFC3H1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002861032 – 1989Zinc finger C3H1 domain-containing proteinAdd BLAST1988

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei15PhosphoserineCombined sources1
Modified residuei28PhosphoserineCombined sources1
Modified residuei34PhosphoserineCombined sources1
Modified residuei128PhosphoserineCombined sources1
Modified residuei251PhosphoserineCombined sources1
Modified residuei352PhosphoserineCombined sources1
Modified residuei383PhosphoserineCombined sources1
Modified residuei662PhosphoserineCombined sources1
Modified residuei714PhosphoserineCombined sources1
Modified residuei717PhosphoserineCombined sources1
Modified residuei719PhosphoserineCombined sources1
Modified residuei766PhosphothreonineCombined sources1
Modified residuei805PhosphoserineCombined sources1
Modified residuei809PhosphoserineCombined sources1
Modified residuei948PhosphoserineCombined sources1
Modified residuei949PhosphoserineCombined sources1
Modified residuei953PhosphoserineCombined sources1
Modified residuei998PhosphoserineCombined sources1
Modified residuei1046PhosphoserineCombined sources1
Modified residuei1301PhosphoserineCombined sources1
Modified residuei1303PhosphoserineCombined sources1
Modified residuei1304PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO60293.
MaxQBiO60293.
PaxDbiO60293.
PeptideAtlasiO60293.
PRIDEiO60293.

PTM databases

iPTMnetiO60293.
PhosphoSitePlusiO60293.

Expressioni

Gene expression databases

BgeeiENSG00000133858.
CleanExiHS_ZFC3H1.
ExpressionAtlasiO60293. baseline and differential.
GenevisibleiO60293. HS.

Organism-specific databases

HPAiHPA007072.
HPA007151.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MYBP102422EBI-746701,EBI-298355

Protein-protein interaction databases

BioGridi128206. 87 interactors.
IntActiO60293. 27 interactors.
MINTiMINT-1481977.
STRINGi9606.ENSP00000368017.

Structurei

3D structure databases

ProteinModelPortaliO60293.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati1361 – 1400TPR 1Add BLAST40
Repeati1401 – 1434TPR 2Add BLAST34
Repeati1438 – 1471TPR 3Add BLAST34
Repeati1478 – 1511TPR 4Add BLAST34
Repeati1602 – 1635TPR 5Add BLAST34
Repeati1636 – 1669TPR 6Add BLAST34
Repeati1745 – 1778TPR 7Add BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili219 – 259Sequence analysisAdd BLAST41
Coiled coili358 – 389Sequence analysisAdd BLAST32
Coiled coili432 – 487Sequence analysisAdd BLAST56
Coiled coili847 – 909Sequence analysisAdd BLAST63
Coiled coili965 – 989Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi34 – 132Ser-richAdd BLAST99
Compositional biasi542 – 616Pro-richAdd BLAST75

Sequence similaritiesi

Contains 1 C3H1-type zinc finger.Curated
Contains 7 TPR repeats.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1185 – 1206C3H1-typeAdd BLAST22

Keywords - Domaini

Coiled coil, Repeat, TPR repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG4839. Eukaryota.
ENOG410XQ07. LUCA.
GeneTreeiENSGT00390000001116.
HOGENOMiHOG000060198.
HOVERGENiHBG095534.
InParanoidiO60293.
OMAiVKPCPFR.
OrthoDBiEOG091G00CJ.
PhylomeDBiO60293.
TreeFamiTF331613.

Family and domain databases

InterProiIPR003107. HAT.
IPR019607. Putative_zinc-finger_domain.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF10650. zf-C3H1. 1 hit.
[Graphical view]
SMARTiSM00386. HAT. 5 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
PROSITEiPS50293. TPR_REGION. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O60293-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATADTPAPA SSGLSPKEEG ELEDGEISDD DNNSQIRSRS SSSSSGGGLL
60 70 80 90 100
PYPRRRPPHS ARGGGSGGGG GSSSSSSSSQ QQLRNFSRSR HASERGHLRG
110 120 130 140 150
PSSYRPKEPF RSHPPSVRMP SSSLSESSPR PSFWERSHLA LDRFRFRGRP
160 170 180 190 200
YRGGSRWSRG RGVGERGGKP GCRPPLGGGA GSGFSSSQSW REPSPPRKSS
210 220 230 240 250
KSFGRSPSRK QNYSSKNENC VEETFEDLLL KYKQIQLELE CINKDEKLAL
260 270 280 290 300
SSKEENVQED PKTLNFEDQT STDNVSITKD SSKEVAPEEK TQVKTFQAFE
310 320 330 340 350
LKPLRQKLTL PGDKNRLKKV KDGAKPLSLK SDTTDSSQGL QDKEQNLTRR
360 370 380 390 400
ISTSDILSEK KLGEDEEELS ELQLRLLALQ SASKKWQQKE QQVMKESKEK
410 420 430 440 450
LTKTKTVQQK VKTSTKTHSA KKVSTTAKQA LRKQQTKAWK KLQQQKEQER
460 470 480 490 500
QKEEDQRKQA EEEERRKREE EIRKIRDLSN QEEQYNRFMK LVGGKRRSRS
510 520 530 540 550
KSSDPDLRRS LDKQPTDSGG GIYQYDNYEE VAMDTDSETS SPAPSPVQPP
560 570 580 590 600
FFSECSLGYF SPAPSLSLPP PPQVSSLPPL SQPYVEGLCV SLEPLPPLPP
610 620 630 640 650
LPPLPPEDPE QPPKPPFADE EEEEEMLLRE ELLKSLANKR AFKPEETSSN
660 670 680 690 700
SDPPSPPVLN NSHPVPRSNL SIVSINTVSQ PRIQNPKFHR GPRLPRTVIS
710 720 730 740 750
LPKHKSVVVT LNDSDDSESD GEASKSTNSV FGGLESMIKE ARRTAEQASK
760 770 780 790 800
PKVPPKSEKE NDPLRTPEAL PEEKKIEYRL LKEEIANREK QRLIKSDQLK
810 820 830 840 850
TSSSSPANSD VEIDGIGRIA MVTKQVTDAE SKLKKHRILL MKDESVLKNL
860 870 880 890 900
VQQEAKKKES VRNAEAKITK LTEQLQATEK ILNVNRMFLK KLQEQIHRVQ
910 920 930 940 950
QRVTIKKALT LKYGEELARA KAVASKEIGK RKLEQDRFGP NKMMRLDSSP
960 970 980 990 1000
VSSPRKHSAE LIAMEKRRLQ KLEYEYALKI QKLKEARALK AKEQQNISPV
1010 1020 1030 1040 1050
VEEEPEFSLP QPSLHDLTQD KLTLDTEEND VDDEILSGSS RERRRSFLES
1060 1070 1080 1090 1100
NYFTKPNLKH TDTANKECIN KLNKNTVEKP ELFLGLKIGE LQKLYSKADS
1110 1120 1130 1140 1150
LKQLILKTTT GITEKVLHGQ EISVDVDFVT AQSKTMEVKP CPFRPYHSPL
1160 1170 1180 1190 1200
LVFKSYRFSP YYRTKEKLPL SSVSYSNMIE PDQCFCRFDL TGTCNDDDCQ
1210 1220 1230 1240 1250
WQHIQDYTLS RKQLFQDILS YNLSLIGCAE TSTNEEITAS AEKYVEKLFG
1260 1270 1280 1290 1300
VNKDRMSMDQ MAVLLVSNIN ESKGHTPPFT TYKDKRKWKP KFWRKPISDN
1310 1320 1330 1340 1350
SFSSDEEQST GPIKYAFQPE NQINVPALDT VVTPDDVRYF TNETDDIANL
1360 1370 1380 1390 1400
EASVLENPSH VQLWLKLAYK YLNQNEGECS ESLDSALNVL ARALENNKDN
1410 1420 1430 1440 1450
PEIWCHYLRL FSKRGTKDEV QEMCETAVEY APDYQSFWTF LHLESTFEEK
1460 1470 1480 1490 1500
DYVCERMLEF LMGAAKQETS NILSFQLLEA LLFRVQLHIF TGRCQSALAI
1510 1520 1530 1540 1550
LQNALKSAND GIVAEYLKTS DRCLAWLAYI HLIEFNILPS KFYDPSNDNP
1560 1570 1580 1590 1600
SRIVNTESFV MPWQAVQDVK TNPDMLLAVF EDAVKACTDE SLAVEERIEA
1610 1620 1630 1640 1650
CLPLYTNMIA LHQLLERYEA AMELCKSLLE SCPINCQLLE ALVALYLQTN
1660 1670 1680 1690 1700
QHDKARAVWL TAFEKNPQNA EVFYHMCKFF ILQNRGDNLL PFLRKFIASF
1710 1720 1730 1740 1750
FKPGFEKYNN LDLFRYLLNI PGPIDIPSRL CKGNFDDDMF NHQVPYLWLI
1760 1770 1780 1790 1800
YCLCHPLQSS IKETVEAYEA ALGVAMRCDI VQKIWMDYLV FANNRAAGSR
1810 1820 1830 1840 1850
NKVQEFKFFT DLVNRCLVTV PARYPIPFSS ADYWSNYEFH NRVIFFYLSC
1860 1870 1880 1890 1900
VPKTQHSKTL ERFCSVMPAN SGLALRLLQH EWEESNVQIL KLQAKMFTYN
1910 1920 1930 1940 1950
IPTCLATWKI AIAAEIVLKG QREVHRLYQR ALQKLPLCAS LWKDQLLFEA
1960 1970 1980
SEGGKTDNLR KLVSKCQEIG VSLNELLNLN SNKTESKNH
Length:1,989
Mass (Da):226,356
Last modified:May 1, 2007 - v3
Checksum:iE5FED04FAE866FDB
GO
Isoform 2 (identifier: O60293-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1910-1989: IAIAAEIVLK...NSNKTESKNH → M

Note: No experimental confirmation available.
Show »
Length:1,910
Mass (Da):217,490
Checksum:i3C18D0452FB02D65
GO
Isoform 4 (identifier: O60293-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     340-346: LQDKEQN → NGIKYFS
     347-1989: Missing.

Note: No experimental confirmation available.
Show »
Length:346
Mass (Da):37,841
Checksum:i1451AF85D85AB236
GO

Sequence cautioni

The sequence BAA25472 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC86028 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0320701006E → K.Corresponds to variant rs1011332dbSNPEnsembl.1
Natural variantiVAR_0320711807K → R.Corresponds to variant rs11541286dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_024992340 – 346LQDKEQN → NGIKYFS in isoform 4. 1 Publication7
Alternative sequenceiVSP_024993347 – 1989Missing in isoform 4. 1 PublicationAdd BLAST1643
Alternative sequenceiVSP_0249951910 – 1989IAIAA…ESKNH → M in isoform 2. 1 PublicationAdd BLAST80

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011118 mRNA. Translation: BAA25472.2. Different initiation.
BC064336 mRNA. Translation: AAH64336.1. Different termination.
BC073843 mRNA. Translation: AAH73843.1.
AK125035 mRNA. Translation: BAC86028.1. Different initiation.
CCDSiCCDS41813.1. [O60293-1]
PIRiT00325.
RefSeqiNP_659419.3. NM_144982.4. [O60293-1]
UniGeneiHs.245798.
Hs.527874.

Genome annotation databases

EnsembliENST00000378743; ENSP00000368017; ENSG00000133858. [O60293-1]
ENST00000548100; ENSP00000450044; ENSG00000133858. [O60293-4]
ENST00000552994; ENSP00000446995; ENSG00000133858. [O60293-2]
GeneIDi196441.
KEGGihsa:196441.
UCSCiuc001swo.4. human. [O60293-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011118 mRNA. Translation: BAA25472.2. Different initiation.
BC064336 mRNA. Translation: AAH64336.1. Different termination.
BC073843 mRNA. Translation: AAH73843.1.
AK125035 mRNA. Translation: BAC86028.1. Different initiation.
CCDSiCCDS41813.1. [O60293-1]
PIRiT00325.
RefSeqiNP_659419.3. NM_144982.4. [O60293-1]
UniGeneiHs.245798.
Hs.527874.

3D structure databases

ProteinModelPortaliO60293.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128206. 87 interactors.
IntActiO60293. 27 interactors.
MINTiMINT-1481977.
STRINGi9606.ENSP00000368017.

PTM databases

iPTMnetiO60293.
PhosphoSitePlusiO60293.

Polymorphism and mutation databases

BioMutaiZFC3H1.

Proteomic databases

EPDiO60293.
MaxQBiO60293.
PaxDbiO60293.
PeptideAtlasiO60293.
PRIDEiO60293.

Protocols and materials databases

DNASUi196441.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378743; ENSP00000368017; ENSG00000133858. [O60293-1]
ENST00000548100; ENSP00000450044; ENSG00000133858. [O60293-4]
ENST00000552994; ENSP00000446995; ENSG00000133858. [O60293-2]
GeneIDi196441.
KEGGihsa:196441.
UCSCiuc001swo.4. human. [O60293-1]

Organism-specific databases

CTDi196441.
DisGeNETi196441.
GeneCardsiZFC3H1.
H-InvDBHIX0010820.
HGNCiHGNC:28328. ZFC3H1.
HPAiHPA007072.
HPA007151.
neXtProtiNX_O60293.
OpenTargetsiENSG00000133858.
PharmGKBiPA164727644.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4839. Eukaryota.
ENOG410XQ07. LUCA.
GeneTreeiENSGT00390000001116.
HOGENOMiHOG000060198.
HOVERGENiHBG095534.
InParanoidiO60293.
OMAiVKPCPFR.
OrthoDBiEOG091G00CJ.
PhylomeDBiO60293.
TreeFamiTF331613.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000133858-MONOMER.

Miscellaneous databases

ChiTaRSiZFC3H1. human.
GenomeRNAii196441.
PROiO60293.

Gene expression databases

BgeeiENSG00000133858.
CleanExiHS_ZFC3H1.
ExpressionAtlasiO60293. baseline and differential.
GenevisibleiO60293. HS.

Family and domain databases

InterProiIPR003107. HAT.
IPR019607. Putative_zinc-finger_domain.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF10650. zf-C3H1. 1 hit.
[Graphical view]
SMARTiSM00386. HAT. 5 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
PROSITEiPS50293. TPR_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZC3H1_HUMAN
AccessioniPrimary (citable) accession number: O60293
Secondary accession number(s): Q6GMU1
, Q6P2S9, Q6ZV36, Q96BE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: November 2, 2016
This is version 136 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.