Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O60293 (ZC3H1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger C3H1 domain-containing protein
Alternative name(s):
Coiled-coil domain-containing protein 131
Proline/serine-rich coiled-coil protein 2
Gene names
Name:ZFC3H1
Synonyms:CCDC131, KIAA0546, PSRC2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1989 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Contains 1 C3H1-type zinc finger.

Contains 6 HAT repeats.

Contains 5 TPR repeats.

Sequence caution

The sequence BAA25472.2 differs from that shown. Reason: Erroneous initiation.

The sequence BAC86028.1 differs from that shown. Reason: Erroneous initiation.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

MYBP102422EBI-746701,EBI-298355

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O60293-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O60293-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1910-1989: IAIAAEIVLK...NSNKTESKNH → M
Note: No experimental confirmation available.
Isoform 4 (identifier: O60293-4)

The sequence of this isoform differs from the canonical sequence as follows:
     340-346: LQDKEQN → NGIKYFS
     347-1989: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.8
Chain2 – 19891988Zinc finger C3H1 domain-containing protein
PRO_0000286103

Regions

Repeat1361 – 140040TPR 1
Repeat1381 – 141333HAT 1
Repeat1401 – 143434TPR 2
Repeat1415 – 144632HAT 2
Repeat1503 – 153533HAT 3
Repeat1602 – 163534TPR 3
Repeat1636 – 166934TPR 4
Repeat1745 – 177834TPR 5
Repeat1759 – 179436HAT 4
Repeat1804 – 184340HAT 5
Repeat1919 – 195133HAT 6
Zinc finger1185 – 120622C3H1-type
Coiled coil219 – 25941 Potential
Coiled coil358 – 38932 Potential
Coiled coil432 – 48756 Potential
Coiled coil847 – 90963 Potential
Coiled coil965 – 98925 Potential
Compositional bias34 – 13299Ser-rich
Compositional bias542 – 61675Pro-rich

Amino acid modifications

Modified residue21N-acetylalanine Ref.8
Modified residue151Phosphoserine Ref.8
Modified residue281Phosphoserine Ref.4 Ref.5 Ref.8 Ref.10
Modified residue341Phosphoserine Ref.4
Modified residue3521Phosphoserine Ref.5 Ref.8 Ref.10
Modified residue7141Phosphoserine Ref.5 Ref.10
Modified residue7171Phosphoserine Ref.5 Ref.10
Modified residue7191Phosphoserine Ref.5 Ref.10
Modified residue8091Phosphoserine Ref.5 Ref.7
Modified residue9491Phosphoserine Ref.5 Ref.8
Modified residue9531Phosphoserine Ref.5
Modified residue9981Phosphoserine Ref.5
Modified residue10461Phosphoserine Ref.5
Modified residue13031Phosphoserine Ref.5 Ref.8 Ref.10
Modified residue13041Phosphoserine Ref.5 Ref.8 Ref.10

Natural variations

Alternative sequence340 – 3467LQDKEQN → NGIKYFS in isoform 4.
VSP_024992
Alternative sequence347 – 19891643Missing in isoform 4.
VSP_024993
Alternative sequence1910 – 198980IAIAA…ESKNH → M in isoform 2.
VSP_024995
Natural variant10061E → K.
Corresponds to variant rs1011332 [ dbSNP | Ensembl ].
VAR_032070
Natural variant18071K → R.
Corresponds to variant rs11541286 [ dbSNP | Ensembl ].
VAR_032071

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 1, 2007. Version 3.
Checksum: E5FED04FAE866FDB

FASTA1,989226,356
        10         20         30         40         50         60 
MATADTPAPA SSGLSPKEEG ELEDGEISDD DNNSQIRSRS SSSSSGGGLL PYPRRRPPHS 

        70         80         90        100        110        120 
ARGGGSGGGG GSSSSSSSSQ QQLRNFSRSR HASERGHLRG PSSYRPKEPF RSHPPSVRMP 

       130        140        150        160        170        180 
SSSLSESSPR PSFWERSHLA LDRFRFRGRP YRGGSRWSRG RGVGERGGKP GCRPPLGGGA 

       190        200        210        220        230        240 
GSGFSSSQSW REPSPPRKSS KSFGRSPSRK QNYSSKNENC VEETFEDLLL KYKQIQLELE 

       250        260        270        280        290        300 
CINKDEKLAL SSKEENVQED PKTLNFEDQT STDNVSITKD SSKEVAPEEK TQVKTFQAFE 

       310        320        330        340        350        360 
LKPLRQKLTL PGDKNRLKKV KDGAKPLSLK SDTTDSSQGL QDKEQNLTRR ISTSDILSEK 

       370        380        390        400        410        420 
KLGEDEEELS ELQLRLLALQ SASKKWQQKE QQVMKESKEK LTKTKTVQQK VKTSTKTHSA 

       430        440        450        460        470        480 
KKVSTTAKQA LRKQQTKAWK KLQQQKEQER QKEEDQRKQA EEEERRKREE EIRKIRDLSN 

       490        500        510        520        530        540 
QEEQYNRFMK LVGGKRRSRS KSSDPDLRRS LDKQPTDSGG GIYQYDNYEE VAMDTDSETS 

       550        560        570        580        590        600 
SPAPSPVQPP FFSECSLGYF SPAPSLSLPP PPQVSSLPPL SQPYVEGLCV SLEPLPPLPP 

       610        620        630        640        650        660 
LPPLPPEDPE QPPKPPFADE EEEEEMLLRE ELLKSLANKR AFKPEETSSN SDPPSPPVLN 

       670        680        690        700        710        720 
NSHPVPRSNL SIVSINTVSQ PRIQNPKFHR GPRLPRTVIS LPKHKSVVVT LNDSDDSESD 

       730        740        750        760        770        780 
GEASKSTNSV FGGLESMIKE ARRTAEQASK PKVPPKSEKE NDPLRTPEAL PEEKKIEYRL 

       790        800        810        820        830        840 
LKEEIANREK QRLIKSDQLK TSSSSPANSD VEIDGIGRIA MVTKQVTDAE SKLKKHRILL 

       850        860        870        880        890        900 
MKDESVLKNL VQQEAKKKES VRNAEAKITK LTEQLQATEK ILNVNRMFLK KLQEQIHRVQ 

       910        920        930        940        950        960 
QRVTIKKALT LKYGEELARA KAVASKEIGK RKLEQDRFGP NKMMRLDSSP VSSPRKHSAE 

       970        980        990       1000       1010       1020 
LIAMEKRRLQ KLEYEYALKI QKLKEARALK AKEQQNISPV VEEEPEFSLP QPSLHDLTQD 

      1030       1040       1050       1060       1070       1080 
KLTLDTEEND VDDEILSGSS RERRRSFLES NYFTKPNLKH TDTANKECIN KLNKNTVEKP 

      1090       1100       1110       1120       1130       1140 
ELFLGLKIGE LQKLYSKADS LKQLILKTTT GITEKVLHGQ EISVDVDFVT AQSKTMEVKP 

      1150       1160       1170       1180       1190       1200 
CPFRPYHSPL LVFKSYRFSP YYRTKEKLPL SSVSYSNMIE PDQCFCRFDL TGTCNDDDCQ 

      1210       1220       1230       1240       1250       1260 
WQHIQDYTLS RKQLFQDILS YNLSLIGCAE TSTNEEITAS AEKYVEKLFG VNKDRMSMDQ 

      1270       1280       1290       1300       1310       1320 
MAVLLVSNIN ESKGHTPPFT TYKDKRKWKP KFWRKPISDN SFSSDEEQST GPIKYAFQPE 

      1330       1340       1350       1360       1370       1380 
NQINVPALDT VVTPDDVRYF TNETDDIANL EASVLENPSH VQLWLKLAYK YLNQNEGECS 

      1390       1400       1410       1420       1430       1440 
ESLDSALNVL ARALENNKDN PEIWCHYLRL FSKRGTKDEV QEMCETAVEY APDYQSFWTF 

      1450       1460       1470       1480       1490       1500 
LHLESTFEEK DYVCERMLEF LMGAAKQETS NILSFQLLEA LLFRVQLHIF TGRCQSALAI 

      1510       1520       1530       1540       1550       1560 
LQNALKSAND GIVAEYLKTS DRCLAWLAYI HLIEFNILPS KFYDPSNDNP SRIVNTESFV 

      1570       1580       1590       1600       1610       1620 
MPWQAVQDVK TNPDMLLAVF EDAVKACTDE SLAVEERIEA CLPLYTNMIA LHQLLERYEA 

      1630       1640       1650       1660       1670       1680 
AMELCKSLLE SCPINCQLLE ALVALYLQTN QHDKARAVWL TAFEKNPQNA EVFYHMCKFF 

      1690       1700       1710       1720       1730       1740 
ILQNRGDNLL PFLRKFIASF FKPGFEKYNN LDLFRYLLNI PGPIDIPSRL CKGNFDDDMF 

      1750       1760       1770       1780       1790       1800 
NHQVPYLWLI YCLCHPLQSS IKETVEAYEA ALGVAMRCDI VQKIWMDYLV FANNRAAGSR 

      1810       1820       1830       1840       1850       1860 
NKVQEFKFFT DLVNRCLVTV PARYPIPFSS ADYWSNYEFH NRVIFFYLSC VPKTQHSKTL 

      1870       1880       1890       1900       1910       1920 
ERFCSVMPAN SGLALRLLQH EWEESNVQIL KLQAKMFTYN IPTCLATWKI AIAAEIVLKG 

      1930       1940       1950       1960       1970       1980 
QREVHRLYQR ALQKLPLCAS LWKDQLLFEA SEGGKTDNLR KLVSKCQEIG VSLNELLNLN 


SNKTESKNH 

« Hide

Isoform 2 [UniParc].

Checksum: 3C18D0452FB02D65
Show »

FASTA1,910217,490
Isoform 4 [UniParc].

Checksum: 1451AF85D85AB236
Show »

FASTA34637,841

References

[1]"Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-396 (ISOFORMS 1/2).
Tissue: Blood and Lymph.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 730-1989 (ISOFORM 1).
Tissue: Thalamus.
[4]"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.
Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-28 AND SER-34, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic kidney.
[5]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-28; SER-352; SER-714; SER-717; SER-719; SER-809; SER-949; SER-953; SER-998; SER-1046; SER-1303 AND SER-1304, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[6]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-809, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[8]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15; SER-28; SER-352; SER-949; SER-1303 AND SER-1304, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[9]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-28; SER-352; SER-714; SER-717; SER-719; SER-1303 AND SER-1304, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB011118 mRNA. Translation: BAA25472.2. Different initiation.
BC064336 mRNA. Translation: AAH64336.1. Different termination.
BC073843 mRNA. Translation: AAH73843.1.
AK125035 mRNA. Translation: BAC86028.1. Different initiation.
CCDSCCDS41813.1. [O60293-1]
PIRT00325.
RefSeqNP_659419.3. NM_144982.4. [O60293-1]
UniGeneHs.245798.
Hs.527874.

3D structure databases

ProteinModelPortalO60293.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid128206. 9 interactions.
IntActO60293. 5 interactions.
MINTMINT-1481977.
STRING9606.ENSP00000368017.

PTM databases

PhosphoSiteO60293.

Proteomic databases

MaxQBO60293.
PaxDbO60293.
PRIDEO60293.

Protocols and materials databases

DNASU196441.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000378743; ENSP00000368017; ENSG00000133858. [O60293-1]
ENST00000548100; ENSP00000450044; ENSG00000133858. [O60293-4]
ENST00000552994; ENSP00000446995; ENSG00000133858. [O60293-2]
GeneID196441.
KEGGhsa:196441.
UCSCuc001swo.2. human. [O60293-1]
uc001swp.3. human. [O60293-4]

Organism-specific databases

CTD196441.
GeneCardsGC12M072003.
H-InvDBHIX0010820.
HGNCHGNC:28328. ZFC3H1.
HPAHPA007072.
HPA007151.
neXtProtNX_O60293.
PharmGKBPA164727644.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG274922.
HOGENOMHOG000060198.
HOVERGENHBG095534.
InParanoidO60293.
OMAKFWRKPV.
OrthoDBEOG74FDZZ.
PhylomeDBO60293.
TreeFamTF331613.

Gene expression databases

ArrayExpressO60293.
BgeeO60293.
CleanExHS_ZFC3H1.
GenevestigatorO60293.

Family and domain databases

InterProIPR003107. HAT.
IPR019607. Putative_zinc-finger_domain.
IPR013026. TPR-contain_dom.
[Graphical view]
PfamPF10650. zf-C3H1. 1 hit.
[Graphical view]
SMARTSM00386. HAT. 5 hits.
[Graphical view]
PROSITEPS50293. TPR_REGION. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi196441.
NextBio89476.
PROO60293.

Entry information

Entry nameZC3H1_HUMAN
AccessionPrimary (citable) accession number: O60293
Secondary accession number(s): Q6GMU1 expand/collapse secondary AC list , Q6P2S9, Q6ZV36, Q96BE7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: July 9, 2014
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM