O60293 (ZC3H1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger C3H1 domain-containing protein

Alternative name(s):
Coiled-coil domain-containing protein 131
Proline/serine-rich coiled-coil protein 2

Gene names

Name:	ZFC3H1
Synonyms:	CCDC131, KIAA0546, PSRC2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1989 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities	Contains 1 C3H1-type zinc finger. Contains 6 HAT repeats. Contains 5 TPR repeats.
Sequence caution	The sequence BAA25472.2 differs from that shown. Reason: Erroneous initiation. The sequence BAC86028.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Repeat TPR repeat Zinc-finger
Ligand	Metal-binding Zinc
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	RNA processing Inferred from electronic annotation. Source: InterPro
Cellular_component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
MYB	P10242	2	EBI-746701,EBI-298355

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O60293-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O60293-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1910-1989: IAIAAEIVLK...NSNKTESKNH → M

Note: No experimental confirmation available.

Isoform 4 (identifier: O60293-4)

The sequence of this isoform differs from the canonical sequence as follows:
     340-346: LQDKEQN → NGIKYFS
     347-1989: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.7
	Chain	2 – 1989	1988	Zinc finger C3H1 domain-containing protein		PRO_0000286103
Regions
	Repeat	1361 – 1400	40	TPR 1
	Repeat	1381 – 1413	33	HAT 1
	Repeat	1401 – 1434	34	TPR 2
	Repeat	1415 – 1446	32	HAT 2
	Repeat	1503 – 1535	33	HAT 3
	Repeat	1602 – 1635	34	TPR 3
	Repeat	1636 – 1669	34	TPR 4
	Repeat	1745 – 1778	34	TPR 5
	Repeat	1759 – 1794	36	HAT 4
	Repeat	1804 – 1843	40	HAT 5
	Repeat	1919 – 1951	33	HAT 6
	Zinc finger	1185 – 1206	22	C3H1-type
	Coiled coil	219 – 259	41	Potential
	Coiled coil	358 – 389	32	Potential
	Coiled coil	432 – 487	56	Potential
	Coiled coil	847 – 909	63	Potential
	Coiled coil	965 – 989	25	Potential
	Compositional bias	34 – 132	99	Ser-rich
	Compositional bias	542 – 616	75	Pro-rich
Amino acid modifications
	Modified residue	2	1	N-acetylalanine Ref.7
	Modified residue	15	1	Phosphoserine Ref.7
	Modified residue	28	1	Phosphoserine Ref.4 Ref.5 Ref.7 Ref.9
	Modified residue	34	1	Phosphoserine Ref.4
	Modified residue	352	1	Phosphoserine Ref.5 Ref.7 Ref.9
	Modified residue	714	1	Phosphoserine Ref.5 Ref.9
	Modified residue	717	1	Phosphoserine Ref.5 Ref.9
	Modified residue	719	1	Phosphoserine Ref.5 Ref.9
	Modified residue	809	1	Phosphoserine Ref.5 Ref.6
	Modified residue	949	1	Phosphoserine Ref.5 Ref.7
	Modified residue	953	1	Phosphoserine Ref.5
	Modified residue	998	1	Phosphoserine Ref.5
	Modified residue	1046	1	Phosphoserine Ref.5
	Modified residue	1303	1	Phosphoserine Ref.5 Ref.7 Ref.9
	Modified residue	1304	1	Phosphoserine Ref.5 Ref.7 Ref.9
Natural variations
	Alternative sequence	340 – 346	7	LQDKEQN → NGIKYFS in isoform 4.		VSP_024992
	Alternative sequence	347 – 1989	1643	Missing in isoform 4.		VSP_024993
	Alternative sequence	1910 – 1989	80	IAIAA…ESKNH → M in isoform 2.		VSP_024995
	Natural variant	1006	1	E → K. Corresponds to variant rs1011332 [ dbSNP | Ensembl ].		VAR_032070
	Natural variant	1807	1	K → R. Corresponds to variant rs11541286 [ dbSNP | Ensembl ].		VAR_032071

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 1, 2007. Version 3. Checksum: E5FED04FAE866FDB	FASTA	1,989	226,356
	10 20 30 40 50 60 MATADTPAPA SSGLSPKEEG ELEDGEISDD DNNSQIRSRS SSSSSGGGLL PYPRRRPPHS 70 80 90 100 110 120 ARGGGSGGGG GSSSSSSSSQ QQLRNFSRSR HASERGHLRG PSSYRPKEPF RSHPPSVRMP 130 140 150 160 170 180 SSSLSESSPR PSFWERSHLA LDRFRFRGRP YRGGSRWSRG RGVGERGGKP GCRPPLGGGA 190 200 210 220 230 240 GSGFSSSQSW REPSPPRKSS KSFGRSPSRK QNYSSKNENC VEETFEDLLL KYKQIQLELE 250 260 270 280 290 300 CINKDEKLAL SSKEENVQED PKTLNFEDQT STDNVSITKD SSKEVAPEEK TQVKTFQAFE 310 320 330 340 350 360 LKPLRQKLTL PGDKNRLKKV KDGAKPLSLK SDTTDSSQGL QDKEQNLTRR ISTSDILSEK 370 380 390 400 410 420 KLGEDEEELS ELQLRLLALQ SASKKWQQKE QQVMKESKEK LTKTKTVQQK VKTSTKTHSA 430 440 450 460 470 480 KKVSTTAKQA LRKQQTKAWK KLQQQKEQER QKEEDQRKQA EEEERRKREE EIRKIRDLSN 490 500 510 520 530 540 QEEQYNRFMK LVGGKRRSRS KSSDPDLRRS LDKQPTDSGG GIYQYDNYEE VAMDTDSETS 550 560 570 580 590 600 SPAPSPVQPP FFSECSLGYF SPAPSLSLPP PPQVSSLPPL SQPYVEGLCV SLEPLPPLPP 610 620 630 640 650 660 LPPLPPEDPE QPPKPPFADE EEEEEMLLRE ELLKSLANKR AFKPEETSSN SDPPSPPVLN 670 680 690 700 710 720 NSHPVPRSNL SIVSINTVSQ PRIQNPKFHR GPRLPRTVIS LPKHKSVVVT LNDSDDSESD 730 740 750 760 770 780 GEASKSTNSV FGGLESMIKE ARRTAEQASK PKVPPKSEKE NDPLRTPEAL PEEKKIEYRL 790 800 810 820 830 840 LKEEIANREK QRLIKSDQLK TSSSSPANSD VEIDGIGRIA MVTKQVTDAE SKLKKHRILL 850 860 870 880 890 900 MKDESVLKNL VQQEAKKKES VRNAEAKITK LTEQLQATEK ILNVNRMFLK KLQEQIHRVQ 910 920 930 940 950 960 QRVTIKKALT LKYGEELARA KAVASKEIGK RKLEQDRFGP NKMMRLDSSP VSSPRKHSAE 970 980 990 1000 1010 1020 LIAMEKRRLQ KLEYEYALKI QKLKEARALK AKEQQNISPV VEEEPEFSLP QPSLHDLTQD 1030 1040 1050 1060 1070 1080 KLTLDTEEND VDDEILSGSS RERRRSFLES NYFTKPNLKH TDTANKECIN KLNKNTVEKP 1090 1100 1110 1120 1130 1140 ELFLGLKIGE LQKLYSKADS LKQLILKTTT GITEKVLHGQ EISVDVDFVT AQSKTMEVKP 1150 1160 1170 1180 1190 1200 CPFRPYHSPL LVFKSYRFSP YYRTKEKLPL SSVSYSNMIE PDQCFCRFDL TGTCNDDDCQ 1210 1220 1230 1240 1250 1260 WQHIQDYTLS RKQLFQDILS YNLSLIGCAE TSTNEEITAS AEKYVEKLFG VNKDRMSMDQ 1270 1280 1290 1300 1310 1320 MAVLLVSNIN ESKGHTPPFT TYKDKRKWKP KFWRKPISDN SFSSDEEQST GPIKYAFQPE 1330 1340 1350 1360 1370 1380 NQINVPALDT VVTPDDVRYF TNETDDIANL EASVLENPSH VQLWLKLAYK YLNQNEGECS 1390 1400 1410 1420 1430 1440 ESLDSALNVL ARALENNKDN PEIWCHYLRL FSKRGTKDEV QEMCETAVEY APDYQSFWTF 1450 1460 1470 1480 1490 1500 LHLESTFEEK DYVCERMLEF LMGAAKQETS NILSFQLLEA LLFRVQLHIF TGRCQSALAI 1510 1520 1530 1540 1550 1560 LQNALKSAND GIVAEYLKTS DRCLAWLAYI HLIEFNILPS KFYDPSNDNP SRIVNTESFV 1570 1580 1590 1600 1610 1620 MPWQAVQDVK TNPDMLLAVF EDAVKACTDE SLAVEERIEA CLPLYTNMIA LHQLLERYEA 1630 1640 1650 1660 1670 1680 AMELCKSLLE SCPINCQLLE ALVALYLQTN QHDKARAVWL TAFEKNPQNA EVFYHMCKFF 1690 1700 1710 1720 1730 1740 ILQNRGDNLL PFLRKFIASF FKPGFEKYNN LDLFRYLLNI PGPIDIPSRL CKGNFDDDMF 1750 1760 1770 1780 1790 1800 NHQVPYLWLI YCLCHPLQSS IKETVEAYEA ALGVAMRCDI VQKIWMDYLV FANNRAAGSR 1810 1820 1830 1840 1850 1860 NKVQEFKFFT DLVNRCLVTV PARYPIPFSS ADYWSNYEFH NRVIFFYLSC VPKTQHSKTL 1870 1880 1890 1900 1910 1920 ERFCSVMPAN SGLALRLLQH EWEESNVQIL KLQAKMFTYN IPTCLATWKI AIAAEIVLKG 1930 1940 1950 1960 1970 1980 QREVHRLYQR ALQKLPLCAS LWKDQLLFEA SEGGKTDNLR KLVSKCQEIG VSLNELLNLN SNKTESKNH
	Isoform 2 [UniParc]. Checksum: 3C18D0452FB02D65	FASTA	1,910	217,490
	10 20 30 40 50 60 MATADTPAPA SSGLSPKEEG ELEDGEISDD DNNSQIRSRS SSSSSGGGLL PYPRRRPPHS 70 80 90 100 110 120 ARGGGSGGGG GSSSSSSSSQ QQLRNFSRSR HASERGHLRG PSSYRPKEPF RSHPPSVRMP 130 140 150 160 170 180 SSSLSESSPR PSFWERSHLA LDRFRFRGRP YRGGSRWSRG RGVGERGGKP GCRPPLGGGA 190 200 210 220 230 240 GSGFSSSQSW REPSPPRKSS KSFGRSPSRK QNYSSKNENC VEETFEDLLL KYKQIQLELE 250 260 270 280 290 300 CINKDEKLAL SSKEENVQED PKTLNFEDQT STDNVSITKD SSKEVAPEEK TQVKTFQAFE 310 320 330 340 350 360 LKPLRQKLTL PGDKNRLKKV KDGAKPLSLK SDTTDSSQGL QDKEQNLTRR ISTSDILSEK 370 380 390 400 410 420 KLGEDEEELS ELQLRLLALQ SASKKWQQKE QQVMKESKEK LTKTKTVQQK VKTSTKTHSA 430 440 450 460 470 480 KKVSTTAKQA LRKQQTKAWK KLQQQKEQER QKEEDQRKQA EEEERRKREE EIRKIRDLSN 490 500 510 520 530 540 QEEQYNRFMK LVGGKRRSRS KSSDPDLRRS LDKQPTDSGG GIYQYDNYEE VAMDTDSETS 550 560 570 580 590 600 SPAPSPVQPP FFSECSLGYF SPAPSLSLPP PPQVSSLPPL SQPYVEGLCV SLEPLPPLPP 610 620 630 640 650 660 LPPLPPEDPE QPPKPPFADE EEEEEMLLRE ELLKSLANKR AFKPEETSSN SDPPSPPVLN 670 680 690 700 710 720 NSHPVPRSNL SIVSINTVSQ PRIQNPKFHR GPRLPRTVIS LPKHKSVVVT LNDSDDSESD 730 740 750 760 770 780 GEASKSTNSV FGGLESMIKE ARRTAEQASK PKVPPKSEKE NDPLRTPEAL PEEKKIEYRL 790 800 810 820 830 840 LKEEIANREK QRLIKSDQLK TSSSSPANSD VEIDGIGRIA MVTKQVTDAE SKLKKHRILL 850 860 870 880 890 900 MKDESVLKNL VQQEAKKKES VRNAEAKITK LTEQLQATEK ILNVNRMFLK KLQEQIHRVQ 910 920 930 940 950 960 QRVTIKKALT LKYGEELARA KAVASKEIGK RKLEQDRFGP NKMMRLDSSP VSSPRKHSAE 970 980 990 1000 1010 1020 LIAMEKRRLQ KLEYEYALKI QKLKEARALK AKEQQNISPV VEEEPEFSLP QPSLHDLTQD 1030 1040 1050 1060 1070 1080 KLTLDTEEND VDDEILSGSS RERRRSFLES NYFTKPNLKH TDTANKECIN KLNKNTVEKP 1090 1100 1110 1120 1130 1140 ELFLGLKIGE LQKLYSKADS LKQLILKTTT GITEKVLHGQ EISVDVDFVT AQSKTMEVKP 1150 1160 1170 1180 1190 1200 CPFRPYHSPL LVFKSYRFSP YYRTKEKLPL SSVSYSNMIE PDQCFCRFDL TGTCNDDDCQ 1210 1220 1230 1240 1250 1260 WQHIQDYTLS RKQLFQDILS YNLSLIGCAE TSTNEEITAS AEKYVEKLFG VNKDRMSMDQ 1270 1280 1290 1300 1310 1320 MAVLLVSNIN ESKGHTPPFT TYKDKRKWKP KFWRKPISDN SFSSDEEQST GPIKYAFQPE 1330 1340 1350 1360 1370 1380 NQINVPALDT VVTPDDVRYF TNETDDIANL EASVLENPSH VQLWLKLAYK YLNQNEGECS 1390 1400 1410 1420 1430 1440 ESLDSALNVL ARALENNKDN PEIWCHYLRL FSKRGTKDEV QEMCETAVEY APDYQSFWTF 1450 1460 1470 1480 1490 1500 LHLESTFEEK DYVCERMLEF LMGAAKQETS NILSFQLLEA LLFRVQLHIF TGRCQSALAI 1510 1520 1530 1540 1550 1560 LQNALKSAND GIVAEYLKTS DRCLAWLAYI HLIEFNILPS KFYDPSNDNP SRIVNTESFV 1570 1580 1590 1600 1610 1620 MPWQAVQDVK TNPDMLLAVF EDAVKACTDE SLAVEERIEA CLPLYTNMIA LHQLLERYEA 1630 1640 1650 1660 1670 1680 AMELCKSLLE SCPINCQLLE ALVALYLQTN QHDKARAVWL TAFEKNPQNA EVFYHMCKFF 1690 1700 1710 1720 1730 1740 ILQNRGDNLL PFLRKFIASF FKPGFEKYNN LDLFRYLLNI PGPIDIPSRL CKGNFDDDMF 1750 1760 1770 1780 1790 1800 NHQVPYLWLI YCLCHPLQSS IKETVEAYEA ALGVAMRCDI VQKIWMDYLV FANNRAAGSR 1810 1820 1830 1840 1850 1860 NKVQEFKFFT DLVNRCLVTV PARYPIPFSS ADYWSNYEFH NRVIFFYLSC VPKTQHSKTL 1870 1880 1890 1900 1910 ERFCSVMPAN SGLALRLLQH EWEESNVQIL KLQAKMFTYN IPTCLATWKM
	Isoform 4 [UniParc]. Checksum: 1451AF85D85AB236	FASTA	346	37,841
	10 20 30 40 50 60 MATADTPAPA SSGLSPKEEG ELEDGEISDD DNNSQIRSRS SSSSSGGGLL PYPRRRPPHS 70 80 90 100 110 120 ARGGGSGGGG GSSSSSSSSQ QQLRNFSRSR HASERGHLRG PSSYRPKEPF RSHPPSVRMP 130 140 150 160 170 180 SSSLSESSPR PSFWERSHLA LDRFRFRGRP YRGGSRWSRG RGVGERGGKP GCRPPLGGGA 190 200 210 220 230 240 GSGFSSSQSW REPSPPRKSS KSFGRSPSRK QNYSSKNENC VEETFEDLLL KYKQIQLELE 250 260 270 280 290 300 CINKDEKLAL SSKEENVQED PKTLNFEDQT STDNVSITKD SSKEVAPEEK TQVKTFQAFE 310 320 330 340 LKPLRQKLTL PGDKNRLKKV KDGAKPLSLK SDTTDSSQGN GIKYFS

References

[1]	"Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-396 (ISOFORMS 1/2). Tissue: Blood and Lymph.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 730-1989 (ISOFORM 1). Tissue: Thalamus.
[4]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-28 AND SER-34, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[5]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-28; SER-352; SER-714; SER-717; SER-719; SER-809; SER-949; SER-953; SER-998; SER-1046; SER-1303 AND SER-1304, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[6]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-809, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[7]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15; SER-28; SER-352; SER-949; SER-1303 AND SER-1304, MASS SPECTROMETRY, CLEAVAGE OF INITIATOR METHIONINE. Tissue: Cervix carcinoma.
[8]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-28; SER-352; SER-714; SER-717; SER-719; SER-1303 AND SER-1304, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB011118 mRNA. Translation: BAA25472.2. Different initiation. BC064336 mRNA. Translation: AAH64336.1. Different termination. BC073843 mRNA. Translation: AAH73843.1. AK125035 mRNA. Translation: BAC86028.1. Different initiation.
IPI	IPI00059925. IPI00175146. IPI00743894.
PIR	T00325.
RefSeq	NP_659419.3. NM_144982.4.
UniGene	Hs.527874.
3D structure databases
ProteinModelPortal	O60293.
ModBase	Search...
Protein-protein interaction databases
IntAct	O60293. 5 interactions.
MINT	MINT-1481977.
STRING	9606.ENSP00000368017.
PTM databases
PhosphoSite	O60293.
Proteomic databases
PaxDb	O60293.
PRIDE	O60293.
Protocols and materials databases
DNASU	196441.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000378743; ENSP00000368017; ENSG00000133858. ENST00000548100; ENSP00000450044; ENSG00000133858. ENST00000552994; ENSP00000446995; ENSG00000133858.
GeneID	196441.
KEGG	hsa:196441.
UCSC	uc001swo.2. human. uc001swp.3. human.
Organism-specific databases
CTD	196441.
GeneCards	GC12M072003.
H-InvDB	HIX0010820.
HGNC	HGNC:28328. ZFC3H1.
HPA	HPA007072. HPA007151.
neXtProt	NX_O60293.
PharmGKB	PA164727644.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG274922.
HOGENOM	HOG000060198.
HOVERGEN	HBG095534.
InParanoid	O60293.
OMA	PKTLNFE.
OrthoDB	EOG4CNQQ7.
Gene expression databases
ArrayExpress	O60293.
Bgee	O60293.
CleanEx	HS_ZFC3H1.
Genevestigator	O60293.
Family and domain databases
InterPro	IPR003107. HAT. IPR019607. Putative_zinc-finger_domain. IPR013026. TPR-contain_dom. [Graphical view]
Pfam	PF10650. zf-C3H1. 1 hit. [Graphical view]
SMART	SM00386. HAT. 5 hits. [Graphical view]
PROSITE	PS50005. TPR. False negative. PS50293. TPR_REGION. 2 hits. PS50103. ZF_C3H1. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	196441.
NextBio	89476.

Entry information

Entry name

ZC3H1_HUMAN

Accession

Primary (citable) accession number: O60293
Secondary accession number(s): Q6GMU1 , Q6P2S9, Q6ZV36, Q96BE7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 2007
Last sequence update:	May 1, 2007
Last modified:	May 1, 2013
This is version 100 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.