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Protein

Nucleolar pre-ribosomal-associated protein 1

Gene

URB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar pre-ribosomal-associated protein 1
Alternative name(s):
Nucleolar protein 254 kDa
URB1 ribosome biogenesis 1 homolog
Gene namesi
Name:URB1
Synonyms:C21orf108, KIAA0539, NOP254, NPA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:17344. URB1.

Subcellular locationi

GO - Cellular componenti

  • nucleolus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162408676.

Polymorphism and mutation databases

BioMutaiURB1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 22712271Nucleolar pre-ribosomal-associated protein 1PRO_0000057939Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei17 – 171PhosphoserineBy similarity
Modified residuei1143 – 11431PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO60287.
MaxQBiO60287.
PaxDbiO60287.
PRIDEiO60287.

2D gel databases

SWISS-2DPAGEO60287.

PTM databases

iPTMnetiO60287.
PhosphoSiteiO60287.

Expressioni

Gene expression databases

BgeeiO60287.
CleanExiHS_URB1.
GenevisibleiO60287. HS.

Organism-specific databases

HPAiHPA018334.

Interactioni

Protein-protein interaction databases

BioGridi115207. 40 interactions.
IntActiO60287. 21 interactions.
MINTiMINT-4104004.
STRINGi9606.ENSP00000372199.

Structurei

3D structure databases

ProteinModelPortaliO60287.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG1791. Eukaryota.
ENOG410XR9W. LUCA.
GeneTreeiENSGT00390000014210.
HOGENOMiHOG000113835.
HOVERGENiHBG108197.
InParanoidiO60287.
KOiK14861.
OMAiMCPSVCE.
OrthoDBiEOG7XDBDX.
PhylomeDBiO60287.
TreeFamiTF313756.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR032436. NopRA1_C.
IPR021714. Npa1_N.
[Graphical view]
PfamiPF16201. NopRA1. 1 hit.
PF11707. Npa1. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.

Sequencei

Sequence statusi: Complete.

O60287-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVPKRKASG GQDGAASSAG AAKRARKEEL TGVRFKAQLK DPQGPGPGLE
60 70 80 90 100
AFVSAAKKLP REDVYDVVEG YIKISVECVE IFQLLSGEKR PESETMLIFQ
110 120 130 140 150
VFEAILLRTA SDLSHFHVVG TNIVKKLMNN HMKLICESLY ASGYRLARAC
160 170 180 190 200
LSLMTAMVTQ GPEAARDVCS HFDLNKKTLY TLVTKRDSKG VYDVRQAYVQ
210 220 230 240 250
FALSFLIAGD DSTIVQVLEV KEFIPCIFSS GIKEDRISTI NILLSTLKTK
260 270 280 290 300
VVHNKNITKT QKVRFFTGQL LNHIASLYNW NGITDVNPEN VKVSAEEAGK
310 320 330 340 350
TMVRELVHNF LMDLCCSLKH GINFYDASLG TFGRGGNLTL LHFLLGLKTA
360 370 380 390 400
ADDDLVADLV VNILKVCPDL LNKYFKEVTF SFIPRAKSTW LNNIKLLNKI
410 420 430 440 450
YEAQPEISRA FQTREFIPLP RLLAMVMVTT VPLVCNKSMF TQALNLDSTS
460 470 480 490 500
VRHTALSLIS VILKRALKTV DHCLNKEVWQ ESGVYTAVMM EEFVQLFREA
510 520 530 540 550
LSKILPDLNT VVWVWQSLKK QETKQDDKKG QKRSDGPPAA CDAHQCDDAE
560 570 580 590 600
TILLKAVLLQ VICLYQKVVP HVVMQYNFDF SKLLKGVISE QGLREEVPPI
610 620 630 640 650
LQHHMLKVAL ELPASKFLWL KAQEGPDAEI IGGERSVFYL LMKMFVTSSH
660 670 680 690 700
LQLKSLTKLL IMKILRDTGV FEHTWKELEL WLEHLENTME EDKETVIQFL
710 720 730 740 750
ERILLTLVAN PYSYTDKASD FVQEASMLQA TMTKQEADDM SIPISHIDDV
760 770 780 790 800
LDMVDVLVEG SEGLDEEIGF TLSEDMILLT FPFSAVVPAA LEARNKLLLG
810 820 830 840 850
TGNEAAENVV TYLTAVLTDL LHTQRDPLAL CLLLQAYDKL EPPCLVPCCQ
860 870 880 890 900
QLSRFNRYYS LWIPEQAREA WLLQAQGSPS PPALPLASSF TALLQAAYES
910 920 930 940 950
QALRDEHIQV QLQATMPHLS MQQVLLAAKQ VLLYLRSTVE NFGQLGRSVG
960 970 980 990 1000
PPLLQLFLDL LRRLVVHCEQ LDAQNQQRCE AARAEADLFL DMESVASLEL
1010 1020 1030 1040 1050
ANDQTLEEVL VAILRHPTLE GWFLALEQQA LPPHTLSPVL VKLLATHFSA
1060 1070 1080 1090 1100
GVLQLLAASA PILQNIGQLG LLARYSEAIT QSVLKELQNR RAGPATSPPK
1110 1120 1130 1140 1150
TPPQLEALQE LHPYMEGAQL REVTLALLSL PETHLVTQQP TKSPGKERHL
1160 1170 1180 1190 1200
NALGKTLVQL LTCSPQDQLQ SGELLWSSEY VRGLGALLPT LAVDELDTVL
1210 1220 1230 1240 1250
LHTLQRDPVL APAVGADLLD YCLARRTQAA LSIAALLLQE SCTHLLWFEQ
1260 1270 1280 1290 1300
WCLQAGPGLG LQGDLDDFLP LIHVYLQCRT RSHFTRPAGV SSAVIPVLRK
1310 1320 1330 1340 1350
TLWRQLQSRL LSTDSPPASG LYQEILAQLV PFARAKDLSV LMDRLPSLLH
1360 1370 1380 1390 1400
TPSSHKRWIV ADSISAALEG SAEELCAWRR TLLESCVKWL IVSFSGGQQD
1410 1420 1430 1440 1450
DDNTQNQEKE MLLRLNALLH ALNEVDPGDW QKFVKKGLKF RYQDHTFLKM
1460 1470 1480 1490 1500
LLTAVQLLYS PESSVRTKLI QLPVVYVMLM QHSLFLPTLL TSDGEESPDS
1510 1520 1530 1540 1550
QVKEALVDLM LTVVEMCPSV CESSHFAVLL GAYGATLSVL DQKILLLLRA
1560 1570 1580 1590 1600
YEQNKLSLIN FRVLLWGPAA VEHHKTCRSL GRSLWQQPSV GDILRLLDRD
1610 1620 1630 1640 1650
RMMQTILHFP QNRRLLPPED TQELIFKDKS RVDLDGLYDP CFLLQLFSEL
1660 1670 1680 1690 1700
TRPEFVVDCR KFLDSNALGL TVTALSSYDP QMRAIAYHVL AAYYSHLEGA
1710 1720 1730 1740 1750
RFQEQSQLLY LLDVVRNGIR TQDMRLTFTL ALFIAKAALQ ILKPEEHMYL
1760 1770 1780 1790 1800
KVSNFLLSHE YLNMDKVPGF YQFFYSSDFE QKTEQKWVFG VLRQGIRDKQ
1810 1820 1830 1840 1850
CYELCARRGI FHIILSFFHS PLCDEAAQNW ILEILQNAAQ VARSAYEIIR
1860 1870 1880 1890 1900
DYSLLTWILH ILESKFLETP LLSNVISLLH TLWVTNLGDK AVEWESQRLC
1910 1920 1930 1940 1950
QPSSQEPAKR LALHLVNEFL YVLIVLMKHL RPTLAPVQLT NFFGTLDSVL
1960 1970 1980 1990 2000
RYRATVIQAF RDMNRFTVNE TVLSTKDVLV LLHKWSLIER DLKLQEDLRA
2010 2020 2030 2040 2050
AIEKAQAREL MKMLKDKNKP VMPARAKGPR GRKRRPGEAE EMADPELMAS
2060 2070 2080 2090 2100
TLETCKGLLR SILTYWRPVI PGPDPTQEPV DSASPESDAP GPVYAAASLA
2110 2120 2130 2140 2150
VSWVLRSVAE HPLSRAEAAG LIGWLKSHIL PHPVVVADLL KDSAVRSSIF
2160 2170 2180 2190 2200
RLYSRLCGAE GLAGPVQEVA CLFNTVMLQL VAAQGRAGSP FHPAMEALSL
2210 2220 2230 2240 2250
SSLSEKDEAT QASAAFLVSL YIKDIWLGAQ RPDTLLTHVR MVCEAADDAP
2260 2270
SSEEEAIVVL CKDAASAASD A
Length:2,271
Mass (Da):254,389
Last modified:November 24, 2009 - v4
Checksum:i1217E7A724E816D8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti368 – 3681P → S in BAA25465 (PubMed:9628581).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1791 – 17911V → L.2 Publications
Corresponds to variant rs3761342 [ dbSNP | Ensembl ].
VAR_060586
Natural varianti2071 – 20711P → R.
Corresponds to variant rs762225 [ dbSNP | Ensembl ].
VAR_059705

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000266 Genomic DNA. No translation available.
AP000267 Genomic DNA. No translation available.
AP000268 Genomic DNA. No translation available.
AP000269 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09876.1.
CH471079 Genomic DNA. Translation: EAX09877.1.
CT001610 mRNA. No translation available.
AF231919 mRNA. Translation: AAF72943.1.
AB011111 mRNA. Translation: BAA25465.2.
AF432264 mRNA. Translation: AAL28110.1.
CCDSiCCDS46645.1.
PIRiT00269.
RefSeqiNP_055640.2. NM_014825.2.
UniGeneiHs.473611.

Genome annotation databases

EnsembliENST00000382751; ENSP00000372199; ENSG00000142207.
GeneIDi9875.
KEGGihsa:9875.
UCSCiuc002ypn.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000266 Genomic DNA. No translation available.
AP000267 Genomic DNA. No translation available.
AP000268 Genomic DNA. No translation available.
AP000269 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09876.1.
CH471079 Genomic DNA. Translation: EAX09877.1.
CT001610 mRNA. No translation available.
AF231919 mRNA. Translation: AAF72943.1.
AB011111 mRNA. Translation: BAA25465.2.
AF432264 mRNA. Translation: AAL28110.1.
CCDSiCCDS46645.1.
PIRiT00269.
RefSeqiNP_055640.2. NM_014825.2.
UniGeneiHs.473611.

3D structure databases

ProteinModelPortaliO60287.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115207. 40 interactions.
IntActiO60287. 21 interactions.
MINTiMINT-4104004.
STRINGi9606.ENSP00000372199.

PTM databases

iPTMnetiO60287.
PhosphoSiteiO60287.

Polymorphism and mutation databases

BioMutaiURB1.

2D gel databases

SWISS-2DPAGEO60287.

Proteomic databases

EPDiO60287.
MaxQBiO60287.
PaxDbiO60287.
PRIDEiO60287.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382751; ENSP00000372199; ENSG00000142207.
GeneIDi9875.
KEGGihsa:9875.
UCSCiuc002ypn.3. human.

Organism-specific databases

CTDi9875.
GeneCardsiURB1.
H-InvDBHIX0016060.
HGNCiHGNC:17344. URB1.
HPAiHPA018334.
MIMi608865. gene.
neXtProtiNX_O60287.
PharmGKBiPA162408676.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1791. Eukaryota.
ENOG410XR9W. LUCA.
GeneTreeiENSGT00390000014210.
HOGENOMiHOG000113835.
HOVERGENiHBG108197.
InParanoidiO60287.
KOiK14861.
OMAiMCPSVCE.
OrthoDBiEOG7XDBDX.
PhylomeDBiO60287.
TreeFamiTF313756.

Miscellaneous databases

GenomeRNAii9875.
NextBioi37223.
PROiO60287.
SOURCEiSearch...

Gene expression databases

BgeeiO60287.
CleanExiHS_URB1.
GenevisibleiO60287. HS.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR032436. NopRA1_C.
IPR021714. Npa1_N.
[Graphical view]
PfamiPF16201. NopRA1. 1 hit.
PF11707. Npa1. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-186.
    Tissue: T-cell.
  4. "Criteria for gene identification and features of genome organization: analysis of 6.5 Mb of DNA sequence from human chromosome 21."
    Slavov D., Hattori M., Sakaki Y., Rosenthal A., Shimizu N., Minoshima S., Kudoh J., Yaspo M.-L., Ramser J., Reinhardt R., Reimer C., Clancy K., Rynditch A., Gardiner K.
    Gene 247:215-232(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 24-2271, VARIANT LEU-1791.
  5. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 226-2271, VARIANT LEU-1791.
    Tissue: Brain.
  6. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  7. "Homo sapiens KIAA0539 mRNA."
    Casadei R., Strippoli P., D'Addabbo P., Canaider S., Lenzi L., Vitale L., Giannone S., Carinci P., Zannotti M.
    Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1297-1538.
    Tissue: Placenta.
  8. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "NOP132 is required for proper nucleolus localization of DEAD-box RNA helicase DDX47."
    Sekiguchi T., Hayano T., Yanagida M., Takahashi N., Nishimoto T.
    Nucleic Acids Res. 34:4593-4608(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1143, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiNPA1P_HUMAN
AccessioniPrimary (citable) accession number: O60287
Secondary accession number(s): D3DSE5, Q96NX1, Q9NYQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 24, 2009
Last modified: April 13, 2016
This is version 130 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.