Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Suppression of tumorigenicity 18 protein

Gene

ST18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Repressor that binds to DNA sequences containing a bipartite element consisting of a direct repeat of the sequence 5'-AAAGTTT-3' separated by 2-9 nucleotides. Represses basal transcription activity from target promoters (By similarity). Inhibits colony formation in cultured breast cancer cells.By similarity1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri365 – 39531C2HC-type 1Add
BLAST
Zinc fingeri409 – 43931C2HC-type 2Add
BLAST
Zinc fingeri721 – 75131C2HC-type 3Add
BLAST
Zinc fingeri765 – 79531C2HC-type 4Add
BLAST
Zinc fingeri813 – 84331C2HC-type 5Add
BLAST
Zinc fingeri866 – 89631C2HC-type 6Add
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Suppression of tumorigenicity 18 protein
Alternative name(s):
Zinc finger protein 387
Gene namesi
Name:ST18
Synonyms:KIAA0535, ZNF387
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:18695. ST18.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38642.

Polymorphism and mutation databases

BioMutaiST18.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10471047Suppression of tumorigenicity 18 proteinPRO_0000234030Add
BLAST

Proteomic databases

MaxQBiO60284.
PaxDbiO60284.
PRIDEiO60284.

PTM databases

iPTMnetiO60284.
PhosphoSiteiO60284.

Expressioni

Tissue specificityi

Detected at low levels in heart, liver, kidney, skeletal muscle, pancreas, testis, ovary and prostate. Detected at even lower levels in mammary epithelial cells and breast cancer cells.1 Publication

Gene expression databases

BgeeiO60284.
CleanExiHS_ST18.
ExpressionAtlasiO60284. baseline and differential.
GenevisibleiO60284. HS.

Organism-specific databases

HPAiHPA044919.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000276480.

Structurei

Secondary structure

1
1047
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi823 – 8253Combined sources
Beta strandi827 – 8304Combined sources
Beta strandi835 – 8373Combined sources
Helixi841 – 8477Combined sources
Turni890 – 8923Combined sources
Helixi894 – 8996Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CS8NMR-A812-906[»]
ProteinModelPortaliO60284.
SMRiO60284. Positions 364-468, 721-906.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO60284.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili920 – 99273Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 6 C2HC-type zinc fingers.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri365 – 39531C2HC-type 1Add
BLAST
Zinc fingeri409 – 43931C2HC-type 2Add
BLAST
Zinc fingeri721 – 75131C2HC-type 3Add
BLAST
Zinc fingeri765 – 79531C2HC-type 4Add
BLAST
Zinc fingeri813 – 84331C2HC-type 5Add
BLAST
Zinc fingeri866 – 89631C2HC-type 6Add
BLAST

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IQ4N. Eukaryota.
ENOG410XNSU. LUCA.
GeneTreeiENSGT00440000038465.
HOGENOMiHOG000234099.
HOVERGENiHBG006433.
InParanoidiO60284.
OMAiVNAAFYQ.
OrthoDBiEOG7060Q4.
PhylomeDBiO60284.
TreeFamiTF317299.

Family and domain databases

InterProiIPR013681. Myelin_TF.
IPR002515. Znf_C2HC.
[Graphical view]
PfamiPF08474. MYT1. 1 hit.
PF01530. zf-C2HC. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O60284-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAEAEDKTL RTRSKGTEVP MDSLIQELSV AYDCSMAKKR TAEDQALGVP
60 70 80 90 100
VNKRKSLLMK PRHYSPKADC QEDRSDRTED DGPLETHGHS TAEEIMIKPM
110 120 130 140 150
DESLLSTAQE NSSRKEDRYS CYQELMVKSL MHLGKFEKNV SVQTVSENLN
160 170 180 190 200
DSGIQSLKAE SDEADECFLI HSDDGRDKID DSQPPFCSSD DNESNSESAE
210 220 230 240 250
NGWDSGSNFS EETKPPRVPK YVLTDHKKDL LEVPEIKTEG DKFIPCENRC
260 270 280 290 300
DSETERKDPQ NALAEPLDGN AQPSFPDVEE EDSESLAVMT EEGSDLEKAK
310 320 330 340 350
GNLSLLEQAI ALQAERGCVF HNTYKELDRF LLEHLAGERR QTKVIDMGGR
360 370 380 390 400
QIFNNKHSPR PEKRETKCPI PGCDGTGHVT GLYPHHRSLS GCPHKVRVPL
410 420 430 440 450
EILAMHENVL KCPTPGCTGR GHVNSNRNTH RSLSGCPIAA AEKLAMSQDK
460 470 480 490 500
NQLDSPQTGQ CPDQAHRTSL VKQIEFNFPS QAITSPRATV SKEQEKFGKV
510 520 530 540 550
PFDYASFDAQ VFGKRPLIQT VQGRKTPPFP ESKHFPNPVK FPNRLPSAGA
560 570 580 590 600
HTQSPGRASS YSYGQCSEDT HIAAAAAILN LSTRCREATD ILSNKPQSLH
610 620 630 640 650
AKGAEIEVDE NGTLDLSMKK NRILDKSAPL TSSNTSIPTP SSSPFKTSSI
660 670 680 690 700
LVNAAFYQAL CDQEGWDTPI NYSKTHGKTE EEKEKDPVSS LENLEEKKFP
710 720 730 740 750
GEASIPSPKP KLHARDLKKE LITCPTPGCD GSGHVTGNYA SHRSVSGCPL
760 770 780 790 800
ADKTLKSLMA ANSQELKCPT PGCDGSGHVT GNYASHRSLS GCPRARKGGV
810 820 830 840 850
KMTPTKEEKE DPELKCPVIG CDGQGHISGK YTSHRTASGC PLAAKRQKEN
860 870 880 890 900
PLNGASLSWK LNKQELPHCP LPGCNGLGHV NNVFVTHRSL SGCPLNAQVI
910 920 930 940 950
KKGKVSEELM TIKLKATGGI ESDEEIRHLD EEIKELNESN LKIEADMMKL
960 970 980 990 1000
QTQITSMESN LKTIEEENKL IEQNNESLLK ELAGLSQALI SSLADIQLPQ
1010 1020 1030 1040
MGPISEQNFE AYVNTLTDMY SNLERDYSPE CKALLESIKQ AVKGIHV
Length:1,047
Mass (Da):115,155
Last modified:August 1, 1998 - v1
Checksum:i4EE28F09AE7C106B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti515 – 5151R → C.
Corresponds to variant rs2303460 [ dbSNP | Ensembl ].
VAR_052732

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011107 mRNA. Translation: BAA25461.1.
BC117147 mRNA. Translation: AAI17148.1.
BC117149 mRNA. Translation: AAI17150.1.
CCDSiCCDS6149.1.
RefSeqiNP_055497.1. NM_014682.2.
XP_006716550.1. XM_006716487.1.
XP_011515931.1. XM_011517629.1.
XP_011515932.1. XM_011517630.1.
XP_011515933.1. XM_011517631.1.
XP_011515934.1. XM_011517632.1.
XP_011515935.1. XM_011517633.1.
XP_011515936.1. XM_011517634.1.
XP_011515937.1. XM_011517635.1.
XP_011515938.1. XM_011517636.1.
XP_011515939.1. XM_011517637.1.
XP_011515940.1. XM_011517638.1.
UniGeneiHs.655499.

Genome annotation databases

EnsembliENST00000276480; ENSP00000276480; ENSG00000147488.
GeneIDi9705.
KEGGihsa:9705.
UCSCiuc003xra.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011107 mRNA. Translation: BAA25461.1.
BC117147 mRNA. Translation: AAI17148.1.
BC117149 mRNA. Translation: AAI17150.1.
CCDSiCCDS6149.1.
RefSeqiNP_055497.1. NM_014682.2.
XP_006716550.1. XM_006716487.1.
XP_011515931.1. XM_011517629.1.
XP_011515932.1. XM_011517630.1.
XP_011515933.1. XM_011517631.1.
XP_011515934.1. XM_011517632.1.
XP_011515935.1. XM_011517633.1.
XP_011515936.1. XM_011517634.1.
XP_011515937.1. XM_011517635.1.
XP_011515938.1. XM_011517636.1.
XP_011515939.1. XM_011517637.1.
XP_011515940.1. XM_011517638.1.
UniGeneiHs.655499.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CS8NMR-A812-906[»]
ProteinModelPortaliO60284.
SMRiO60284. Positions 364-468, 721-906.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000276480.

PTM databases

iPTMnetiO60284.
PhosphoSiteiO60284.

Polymorphism and mutation databases

BioMutaiST18.

Proteomic databases

MaxQBiO60284.
PaxDbiO60284.
PRIDEiO60284.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000276480; ENSP00000276480; ENSG00000147488.
GeneIDi9705.
KEGGihsa:9705.
UCSCiuc003xra.3. human.

Organism-specific databases

CTDi9705.
GeneCardsiST18.
HGNCiHGNC:18695. ST18.
HPAiHPA044919.
neXtProtiNX_O60284.
PharmGKBiPA38642.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQ4N. Eukaryota.
ENOG410XNSU. LUCA.
GeneTreeiENSGT00440000038465.
HOGENOMiHOG000234099.
HOVERGENiHBG006433.
InParanoidiO60284.
OMAiVNAAFYQ.
OrthoDBiEOG7060Q4.
PhylomeDBiO60284.
TreeFamiTF317299.

Miscellaneous databases

EvolutionaryTraceiO60284.
GenomeRNAii9705.
PROiO60284.

Gene expression databases

BgeeiO60284.
CleanExiHS_ST18.
ExpressionAtlasiO60284. baseline and differential.
GenevisibleiO60284. HS.

Family and domain databases

InterProiIPR013681. Myelin_TF.
IPR002515. Znf_C2HC.
[Graphical view]
PfamiPF08474. MYT1. 1 hit.
PF01530. zf-C2HC. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  4. "Solution structure of tandem repeat of the fifth and sixth zinc-finger C2HC domains from human ST18."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2005) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 812-906 IN COMPLEX WITH ZINC IONS.

Entry informationi

Entry nameiST18_HUMAN
AccessioniPrimary (citable) accession number: O60284
Secondary accession number(s): Q17RY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: August 1, 1998
Last modified: June 8, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.