Reviewed,
UniProtKB/Swiss-Prot O60282 (KIF5C_HUMAN)
Last modified
February 9, 2010.
Version 84.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Kinesin heavy chain isoform 5C Alternative name(s): Kinesin heavy chain neuron-specific 2 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 957 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. |
| Subunit structure | Oligomer composed of two heavy chains and two light chains. Interacts with GRIP1 and KLC3 By similarity. |
| Tissue specificity | Highest expression in brain, prostate and testis, and moderate expression in kidney, small intestine and ovary. |
| Domain | Composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles. |
| Sequence similarities | Belongs to the kinesin-like protein family. Kinesin subfamily. Contains 1 kinesin-motor domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Microtubule |
| Coding sequence diversity | Alternative splicing |
| Domain | Coiled coil |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Motor protein |
| PTM | Phosphoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | microtubule-based movement Inferred from electronic annotation. Source: InterPro organelle organizationTraceable author statement. Source: ProtInc |
| Cellular component | kinesin complex Traceable author statement. Source: ProtInc microtubuleInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW microtubule motor activityTraceable author statement. Source: ProtInc protein bindingInferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| RHOT1 | Q8IXI2 | 2 | EBI-717170,EBI-1396430 | |
| YWHAG | P61981 | 1 | EBI-717170,EBI-359832 | |
| YWHAQ | P27348 | 1 | EBI-717170,EBI-359854 |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: O60282-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: O60282-2) The sequence of this isoform differs from the canonical sequence as follows: 1-232: Missing. 233-238: LAGSEK → MATYIH |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 957 | 957 | Kinesin heavy chain isoform 5C | PRO_0000125355 | |||||
Regions | |||||||||
| Domain | 1 – 386 | 386 | Kinesin-motor | ||||||
| Nucleotide binding | 86 – 93 | 8 | ATP By similarity | ||||||
| Region | 174 – 315 | 142 | Microtubule-binding | ||||||
| Region | 859 – 956 | 98 | Globular | ||||||
| Coiled coil | 406 – 923 | 518 | |||||||
Amino acid modifications | |||||||||
| Modified residue | 338 | 1 | Phosphothreonine By similarity | ||||||
| Modified residue | 797 | 1 | Phosphothreonine By similarity | ||||||
Natural variations | |||||||||
| Alternative sequence | 1 – 232 | 232 | Missing in isoform 2. | VSP_035715 | |||||
| Alternative sequence | 233 – 238 | 6 | LAGSEK → MATYIH in isoform 2. | VSP_035716 | |||||
Experimental info | |||||||||
| Sequence conflict | 355 – 360 | 6 | TLKNVI → STHASV in AAD01436. Ref.4 | ||||||
| Sequence conflict | 583 – 585 | 3 | EFT → DRV in AAD01436. Ref.4 | ||||||
Sequences
| ||||||||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:31-39(1998) [PubMed: 9628581] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain. |
| [2] | "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. Wilson R.K.Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain. |
| [4] | "Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin." Engelender S., Sharp A.H., Colomer V., Tokito M.K., Lanahan A., Worley P., Holzbaur E.L.F., Ross C.A. Hum. Mol. Genet. 6:2205-2212(1997) [PubMed: 9361024] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 355-585 (ISOFORMS 1/2). |
| [5] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AB011103 mRNA. Translation: BAA25457.2. Different initiation. AC105402 Genomic DNA. No translation available. AC108512 Genomic DNA. No translation available. AC144443 Genomic DNA. No translation available. AC144611 Genomic DNA. No translation available. BC110287 mRNA. Translation: AAI10288.1. AF010146 mRNA. Translation: AAD01436.1. |
| IPI | IPI00028561. IPI00889664. |
| RefSeq | NP_004513.1. |
| UniGene | Hs.435557 Hs.660699 |
3D structure databases | |
| SMR | O60282. Positions 3-327, 256-372. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | O60282. 7 interactions. |
| STRING | O60282. |
Proteomic databases | |
| PRIDE | O60282. |
Genome annotation databases | |
| Ensembl | ENST00000435030; ENSP00000393379; ENSG00000168280; Homo sapiens. [Genome view] |
| GeneID | 3800. |
| KEGG | hsa:3800. |
| UCSC | uc002twr.1. human. |
Organism-specific databases | |
| CTD | 3800. |
| GeneCards | GC02P149349. |
| H-InvDB | HIX0002499. |
| HGNC | HGNC:6325. KIF5C. |
| MIM | 604593. gene. |
| PharmGKB | PA30109. |
| HUGE | Search... |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | HBG381775. |
| HOVERGEN | O60282. |
| InParanoid | O60282. |
| OMA | RWRNGEA. |
| OrthoDB | EOG9J13TB. |
| PhylomeDB | O60282. |
Gene expression databases | |
| ArrayExpress | O60282. |
| Bgee | O60282. |
| CleanEx | HS_KIF5C. |
| Genevestigator | O60282. |
| GermOnline | ENSG00000168280. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR019821. Kinesin_motor_CS. IPR001752. Kinesin_motor_dom. [Graphical view] |
| Gene3D | G3DSA:3.40.850.10. kinesin_motor. 1 hit. |
| Pfam | PF00225. Kinesin. 1 hit. [Graphical view] |
| PRINTS | PR00380. KINESINHEAVY. |
| SMART | SM00129. KISc. 1 hit. [Graphical view] |
| PROSITE | PS00411. KINESIN_MOTOR_DOMAIN1. 1 hit. PS50067. KINESIN_MOTOR_DOMAIN2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 14921. |
| SOURCE | Search... |
Entry information
| Entry name | KIF5C_HUMAN | ||||||||
| Accession | Primary (citable) accession number: O60282 Secondary accession number(s): O95079, Q2YDC5 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 2 Human chromosome 2: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


