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Protein

Zinc finger protein 292

Gene

ZNF292

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri569 – 59123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri681 – 70525C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri722 – 74423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri750 – 77425C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri779 – 80325C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri807 – 83125C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1098 – 112326C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1375 – 139723C2H2-type 8; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1902 – 192726C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1947 – 197226C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri2114 – 213926C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri2172 – 219726C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri2216 – 224126C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri2256 – 228126C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri2386 – 241025C2H2-type 15PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 292
Gene namesi
Name:ZNF292
Synonyms:KIAA0530
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:18410. ZNF292.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134945416.

Polymorphism and mutation databases

BioMutaiZNF292.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 27232723Zinc finger protein 292PRO_0000047514Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei654 – 6541PhosphoserineBy similarity
Modified residuei1117 – 11171N6-acetyllysineBy similarity
Modified residuei1159 – 11591PhosphoserineCombined sources
Modified residuei2042 – 20421N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO60281.
MaxQBiO60281.
PaxDbiO60281.
PeptideAtlasiO60281.
PRIDEiO60281.

PTM databases

iPTMnetiO60281.
PhosphoSiteiO60281.

Expressioni

Gene expression databases

BgeeiENSG00000188994.
CleanExiHS_ZNF292.
ExpressionAtlasiO60281. baseline and differential.
GenevisibleiO60281. HS.

Organism-specific databases

HPAiHPA032154.

Interactioni

Protein-protein interaction databases

BioGridi116675. 8 interactions.
IntActiO60281. 9 interactions.
STRINGi9606.ENSP00000358590.

Structurei

Secondary structure

1
2723
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2105 – 21084Combined sources
Helixi2128 – 213811Combined sources
Beta strandi2139 – 21413Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1X3CNMR-A2094-2153[»]
ProteinModelPortaliO60281.
SMRiO60281. Positions 2094-2154.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO60281.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1827 – 185428Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 15 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri569 – 59123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri681 – 70525C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri722 – 74423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri750 – 77425C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri779 – 80325C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri807 – 83125C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1098 – 112326C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1375 – 139723C2H2-type 8; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1902 – 192726C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1947 – 197226C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri2114 – 213926C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri2172 – 219726C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri2216 – 224126C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri2256 – 228126C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri2386 – 241025C2H2-type 15PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129803.
HOGENOMiHOG000049278.
HOVERGENiHBG057856.
InParanoidiO60281.
OMAiGKEGIKM.
OrthoDBiEOG091G0032.
PhylomeDBiO60281.
TreeFamiTF350813.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 16 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O60281-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADEEAEQER LSCGEGGCVA ELQRLGERLQ ELELQLRESR VPAVEAATDY
60 70 80 90 100
CQQLCQTLLE YAEKWKTSED PLPLLEVYTV AIQSYVKARP YLTSECENVA
110 120 130 140 150
LVLERLALSC VELLLCLPVE LSDKQWEQFQ TLVQVAHEKL MENGSCELHF
160 170 180 190 200
LATLAQETGV WKNPVLCTIL SQEPLDKDKV NEFLAFEGPI LLDMRIKHLI
210 220 230 240 250
KTNQLSQATA LAKLCSDHPE IGIKGSFKQT YLVCLCTSSP NGKLIEEISE
260 270 280 290 300
VDCKDALEMI CNLESEGDEK SALVLCTAFL SRQLQQGDMY CAWELTLFWS
310 320 330 340 350
KLQQRVEPSI QVYLERCRQL SLLTKTVYHI FFLIKVINSE TEGAGLATCI
360 370 380 390 400
ELCVKALRLE STENTEVKIS ICKTISCLLP DDLEVKRACQ LSEFLIEPTV
410 420 430 440 450
DAYYAVEMLY NQPDQKYDEE NLPIPNSLRC ELLLVLKTQW PFDPEFWDWK
460 470 480 490 500
TLKRQCLALM GEEASIVSSI DELNDSEVYE KVVDYQEESK ETSMNGLSGG
510 520 530 540 550
VGANSGLLKD IGDEKQKKRE IKQLRERGFI SARFRNWQAY MQYCVLCDKE
560 570 580 590 600
FLGHRIVRHA QKHYKDGIYS CPICAKNFNS KETFVPHVTL HVKQSSKERL
610 620 630 640 650
AAMKPLRRLG RPPKITTTNE NQKTNTVAKQ EQRPIKKNSL YSTDFIVFND
660 670 680 690 700
NDGSDDENDD KDKSYEPEVI PVQKPVPVNE FNCPVTFCKK GFKYFKNLIA
710 720 730 740 750
HVKGHKDNED AKRFLEMQSK KVICQYCRRH FVSVTHLNDH LQMHCGSKPY
760 770 780 790 800
ICIQMKCKAG FNSYAELLTH RKEHQVFRAK CMFPKCGRIF SEAYLLYDHE
810 820 830 840 850
AQHYNTYTCK FTGCGKVYRS QGELEKHLDD HSTPPEKVLP PEAQLNSSGD
860 870 880 890 900
SIQPSEVNQN TAENIEKERS MLPSENNIEN SLLADRSDAW DKSKAESAVT
910 920 930 940 950
KQDQISASEL RQANGPLSNG LENPATTPLL QSSEVAVSIK VSLNQGIEDN
960 970 980 990 1000
FGKQENSTVE GSGEALVTDL HTPVEDTCND LCHPGFQERK EQDCFNDAHV
1010 1020 1030 1040 1050
TQNSLVNSET LKIGDLTPQN LERQVNNLMT FSVQNQAAFQ NNLPTSKFEC
1060 1070 1080 1090 1100
GDNVKTSSNL YNLPLKTLES IAFVPPQSDL SNSLGTPSVP PKAPVQKFSC
1110 1120 1130 1140 1150
QVEGCTRTYN SSQSIGKHMK TAHPDQYAAF KMQRKSKKGQ KANNLNTPNN
1160 1170 1180 1190 1200
GKFVYFLPSP VNSSNPFFTS QTKANGNPAC SAQLQHVSPP IFPAHLASVS
1210 1220 1230 1240 1250
TPLLSSMESV INPNITSQDK NEQGGMLCSQ MENLPSTALP AQMEDLTKTV
1260 1270 1280 1290 1300
LPLNIDSGSD PFLPLPAESS SMSLFPSPAD SGTNSVFSQL ENNTNHYSSQ
1310 1320 1330 1340 1350
IEGNTNSSFL KGGNGENAVF PSQVNVANNF SSTNAQQSAP EKVKKDRGRG
1360 1370 1380 1390 1400
PNGKERKPKH NKRAKWPAII RDGKFICSRC YRAFTNPRSL GGHLSKRSYC
1410 1420 1430 1440 1450
KPLDGAEIAQ ELLQSNGQPS LLASMILSTN AVNLQQPQQS TFNPEACFKD
1460 1470 1480 1490 1500
PSFLQLLAEN RSPAFLPNTF PRSGVTNFNT SVSQEGSEII KQALETAGIP
1510 1520 1530 1540 1550
STFEGAEMLS HVSTGCVSDA SQVNATVMPN PTVPPLLHTV CHPNTLLTNQ
1560 1570 1580 1590 1600
NRTSNSKTSS IEECSSLPVF PTNDLLLKTV ENGLCSSSFP NSGGPSQNFT
1610 1620 1630 1640 1650
SNSSRVSVIS GPQNTRSSHL NKKGNSASKR RKKVAPPLIA PNASQNLVTS
1660 1670 1680 1690 1700
DLTTMGLIAK SVEIPTTNLH SNVIPTCEPQ SLVENLTQKL NNVNNQLFMT
1710 1720 1730 1740 1750
DVKENFKTSL ESHTVLAPLT LKTENGDSQM MALNSCTTSI NSDLQISEDN
1760 1770 1780 1790 1800
VIQNFEKTLE IIKTAMNSQI LEVKSGSQGA GETSQNAQIN YNIQLPSVNT
1810 1820 1830 1840 1850
VQNNKLPDSS PFSSFISVMP TKSNIPQSEV SHKEDQIQEI LEGLQKLKLE
1860 1870 1880 1890 1900
NDLSTPASQC VLINTSVTLT PTPVKSTADI TVIQPVSEMI NIQFNDKVNK
1910 1920 1930 1940 1950
PFVCQNQGCN YSAMTKDALF KHYGKIHQYT PEMILEIKKN QLKFAPFKCV
1960 1970 1980 1990 2000
VPTCTKTFTR NSNLRAHCQL VHHFTTEEMV KLKIKRPYGR KSQSENVPAS
2010 2020 2030 2040 2050
RSTQVKKQLA MTEENKKESQ PALELRAETQ NTHSNVAVIP EKQLVEKKSP
2060 2070 2080 2090 2100
DKTESSLQVI TVTSEQCNTN ALTNTQTKGR KIRRHKKEKE EKKRKKPVSQ
2110 2120 2130 2140 2150
SLEFPTRYSP YRPYRCVHQG CFAAFTIQQN LILHYQAVHK SDLPAFSAEV
2160 2170 2180 2190 2200
EEESEAGKES EETETKQTLK EFRCQVSDCS RIFQAITGLI QHYMKLHEMT
2210 2220 2230 2240 2250
PEEIESMTAS VDVGKFPCDQ LECKSSFTTY LNYVVHLEAD HGIGLRASKT
2260 2270 2280 2290 2300
EEDGVYKCDC EGCDRIYATR SNLLRHIFNK HNDKHKAHLI RPRRLTPGQE
2310 2320 2330 2340 2350
NMSSKANQEK SKSKHRGTKH SRCGKEGIKM PKTKRKKKNN LENKNAKIVQ
2360 2370 2380 2390 2400
IEENKPYSLK RGKHVYSIKA RNDALSECTS RFVTQYPCMI KGCTSVVTSE
2410 2420 2430 2440 2450
SNIIRHYKCH KLSKAFTSQH RNLLIVFKRC CNSQVKETSE QEGAKNDVKD
2460 2470 2480 2490 2500
SDTCVSESND NSRTTATVSQ KEVEKNEKDE MDELTELFIT KLINEDSTSV
2510 2520 2530 2540 2550
ETQANTSSNV SNDFQEDNLC QSERQKASNL KRVNKEKNVS QNKKRKVEKA
2560 2570 2580 2590 2600
EPASAAELSS VRKEEETAVA IQTIEEHPAS FDWSSFKPMG FEVSFLKFLE
2610 2620 2630 2640 2650
ESAVKQKKNT DKDHPNTGNK KGSHSNSRKN IDKTAVTSGN HVCPCKESET
2660 2670 2680 2690 2700
FVQFANPSQL QCSDNVKIVL DKNLKDCTEL VLKQLQEMKP TVSLKKLEVH
2710 2720
SNDPDMSVMK DISIGKATGR GQY
Length:2,723
Mass (Da):304,816
Last modified:March 23, 2010 - v3
Checksum:iA9E05072E9B64303
GO
Isoform 2 (identifier: O60281-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-140: Missing.
     180-184: Missing.

Note: Gene prediction based on EST data.
Show »
Length:2,578
Mass (Da):288,286
Checksum:i503D04918A8F8F34
GO

Sequence cautioni

The sequence BAB14622 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB14654 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAD97823 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated
The sequence CAD97823 differs from that shown. Reason: Frameshift at position 637. Curated
The sequence CAD97823 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti896 – 8961E → V in BAB14622 (PubMed:14702039).Curated
Sequence conflicti1003 – 10031N → D in BAB14622 (PubMed:14702039).Curated
Sequence conflicti1217 – 12171S → P in CAD97823 (Ref. 2) Curated
Sequence conflicti1355 – 13551E → K in BAB14622 (PubMed:14702039).Curated
Sequence conflicti1530 – 15301N → S in BAB14622 (PubMed:14702039).Curated
Sequence conflicti1846 – 18461K → E in CAD97823 (Ref. 2) Curated
Sequence conflicti1953 – 19531T → A in CAD97823 (Ref. 2) Curated
Sequence conflicti2162 – 21621E → K in BAB14654 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1740 – 17401I → V.2 Publications
Corresponds to variant rs9362415 [ dbSNP | Ensembl ].
VAR_062972
Natural varianti2045 – 20451V → I.1 Publication
Corresponds to variant rs6910541 [ dbSNP | Ensembl ].
VAR_062973

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 140140Missing in isoform 2. CuratedVSP_038857Add
BLAST
Alternative sequencei180 – 1845Missing in isoform 2. CuratedVSP_038858

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139274 Genomic DNA. Translation: CAH73308.1.
BX537746 mRNA. Translation: CAD97823.1. Sequence problems.
AK023626 mRNA. Translation: BAB14622.1. Different initiation.
AK023712 mRNA. Translation: BAB14654.1. Different initiation.
AB011102 mRNA. Translation: BAA25456.1.
CCDSiCCDS47457.1. [O60281-1]
RefSeqiNP_055836.1. NM_015021.1. [O60281-1]
UniGeneiHs.485892.
Hs.656621.

Genome annotation databases

EnsembliENST00000369577; ENSP00000358590; ENSG00000188994. [O60281-1]
GeneIDi23036.
KEGGihsa:23036.
UCSCiuc003plm.5. human. [O60281-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139274 Genomic DNA. Translation: CAH73308.1.
BX537746 mRNA. Translation: CAD97823.1. Sequence problems.
AK023626 mRNA. Translation: BAB14622.1. Different initiation.
AK023712 mRNA. Translation: BAB14654.1. Different initiation.
AB011102 mRNA. Translation: BAA25456.1.
CCDSiCCDS47457.1. [O60281-1]
RefSeqiNP_055836.1. NM_015021.1. [O60281-1]
UniGeneiHs.485892.
Hs.656621.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1X3CNMR-A2094-2153[»]
ProteinModelPortaliO60281.
SMRiO60281. Positions 2094-2154.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116675. 8 interactions.
IntActiO60281. 9 interactions.
STRINGi9606.ENSP00000358590.

PTM databases

iPTMnetiO60281.
PhosphoSiteiO60281.

Polymorphism and mutation databases

BioMutaiZNF292.

Proteomic databases

EPDiO60281.
MaxQBiO60281.
PaxDbiO60281.
PeptideAtlasiO60281.
PRIDEiO60281.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369577; ENSP00000358590; ENSG00000188994. [O60281-1]
GeneIDi23036.
KEGGihsa:23036.
UCSCiuc003plm.5. human. [O60281-1]

Organism-specific databases

CTDi23036.
GeneCardsiZNF292.
HGNCiHGNC:18410. ZNF292.
HPAiHPA032154.
neXtProtiNX_O60281.
PharmGKBiPA134945416.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129803.
HOGENOMiHOG000049278.
HOVERGENiHBG057856.
InParanoidiO60281.
OMAiGKEGIKM.
OrthoDBiEOG091G0032.
PhylomeDBiO60281.
TreeFamiTF350813.

Miscellaneous databases

EvolutionaryTraceiO60281.
GenomeRNAii23036.
PROiO60281.

Gene expression databases

BgeeiENSG00000188994.
CleanExiHS_ZNF292.
ExpressionAtlasiO60281. baseline and differential.
GenevisibleiO60281. HS.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 16 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN292_HUMAN
AccessioniPrimary (citable) accession number: O60281
Secondary accession number(s): Q5W0B2
, Q7Z3L7, Q9H8G3, Q9H8J4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: March 23, 2010
Last modified: September 7, 2016
This is version 152 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.