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Protein

Sushi domain-containing protein 5

Gene

SUSD5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Sushi domain-containing protein 5
Gene namesi
Name:SUSD5
Synonyms:KIAA0527
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:29061. SUSD5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini36 – 574539ExtracellularSequence analysisAdd
BLAST
Transmembranei575 – 59521HelicalSequence analysisAdd
BLAST
Topological domaini596 – 62934CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485627.

Polymorphism and mutation databases

BioMutaiSUSD5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3535Sequence analysisAdd
BLAST
Chaini36 – 629594Sushi domain-containing protein 5PRO_0000274247Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi61 ↔ 132By similarity
Disulfide bondi140 ↔ 184By similarity
Disulfide bondi167 ↔ 197By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiO60279.
MaxQBiO60279.
PaxDbiO60279.
PRIDEiO60279.

PTM databases

iPTMnetiO60279.
PhosphoSiteiO60279.
SwissPalmiO60279.

Expressioni

Gene expression databases

BgeeiO60279.
CleanExiHS_SUSD5.
ExpressionAtlasiO60279. baseline and differential.
GenevisibleiO60279. HS.

Organism-specific databases

HPAiHPA052788.

Interactioni

Protein-protein interaction databases

BioGridi117498. 9 interactions.
STRINGi9606.ENSP00000308727.

Structurei

3D structure databases

ProteinModelPortaliO60279.
SMRiO60279. Positions 39-135.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 13496LinkPROSITE-ProRule annotationAdd
BLAST
Domaini138 – 19962SushiPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Link domain.PROSITE-ProRule annotation
Contains 1 Sushi (CCP/SCR) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFAC. Eukaryota.
ENOG410YBQZ. LUCA.
GeneTreeiENSGT00390000009163.
HOGENOMiHOG000154451.
HOVERGENiHBG108521.
InParanoidiO60279.
OMAiHLFWFPA.
OrthoDBiEOG7J9VP3.
PhylomeDBiO60279.
TreeFamiTF336259.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR000538. Link_dom.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00193. Xlink. 1 hit.
[Graphical view]
SMARTiSM00445. LINK. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
SSF57535. SSF57535. 1 hit.
PROSITEiPS50963. LINK_2. 1 hit.
PS50923. SUSHI. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O60279-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAEGPSPPA RWHRRLPGLW AAALLLLGLP RLSVRADGKF FVLESQNGSQ
60 70 80 90 100
GLQLEAARLS CKSRGAHLAS ADELRRVVQD CSFAVCTTGW LADGTLGTTV
110 120 130 140 150
CSKGSGEQQI MRAVDVRIES NPVPGGTYSA LCIKDEEKPC GDPPSFPHTI
160 170 180 190 200
LQGRTGLEMG DELLYVCAPG HIMGHRETAF TLLCNSCGEW YGLVQACGKD
210 220 230 240 250
EAEAHIDYED NFPDDRSVSF RELMEDSRTE ADEDRGQGDS SEEAPKQDRL
260 270 280 290 300
VSISVGRENI ARDKVFVPTT GLPGAGSSVP ADSPGSRLLQ KHLFWFPAEA
310 320 330 340 350
FHKPGLEKEV DDDTKKQFSA GDNHSGVKLV PGEPETKVIY GNTDGPSGPF
360 370 380 390 400
VGKNDSKAGD PVVSSSDESW LDGYPVTEGA WRKTEAEEEE DGDRGDGSVG
410 420 430 440 450
LDENVLVTPD QPILVEVKKP KSSTLTPSEG MTHSSVLPSQ MLDVEALALR
460 470 480 490 500
PVNASETEGI GDGDLTKYQS TLPWRFITEE SPMATLSYEL TSSTLEILTV
510 520 530 540 550
NTVKQTPNHI PSTIMATTQP PVETTVPEIQ DSFPYLLSED FFGQEGPGPG
560 570 580 590 600
ASEELHPTLE SCVGDGCPGL SRGPVIATIV TVLCLLLLLA GVGMVWGYRK
610 620
CQHKSSVYKL NVGQRQARHY HQQIEMEKV
Length:629
Mass (Da):68,021
Last modified:April 8, 2008 - v3
Checksum:i51CB3C12D932FD9E
GO

Sequence cautioni

The sequence BAA25453.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti272 – 2721L → S in BAA25453 (PubMed:9628581).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti40 – 401F → L.1 Publication
Corresponds to variant rs9637517 [ dbSNP | Ensembl ].
VAR_051391
Natural varianti52 – 521L → F.
Corresponds to variant rs9637517 [ dbSNP | Ensembl ].
VAR_030217
Natural varianti216 – 2161R → K.
Corresponds to variant rs9872477 [ dbSNP | Ensembl ].
VAR_051392
Natural varianti228 – 2281R → K.
Corresponds to variant rs9872477 [ dbSNP | Ensembl ].
VAR_030218
Natural varianti378 – 3781E → D.1 Publication
Corresponds to variant rs6810039 [ dbSNP | Ensembl ].
VAR_051393

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011099 mRNA. Translation: BAA25453.1. Different initiation.
AC123900 Genomic DNA. No translation available.
CCDSiCCDS46787.1.
PIRiT00073.
RefSeqiNP_056366.1. NM_015551.1.
UniGeneiHs.196647.

Genome annotation databases

EnsembliENST00000309558; ENSP00000308727; ENSG00000173705.
GeneIDi26032.
KEGGihsa:26032.
UCSCiuc003cfo.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011099 mRNA. Translation: BAA25453.1. Different initiation.
AC123900 Genomic DNA. No translation available.
CCDSiCCDS46787.1.
PIRiT00073.
RefSeqiNP_056366.1. NM_015551.1.
UniGeneiHs.196647.

3D structure databases

ProteinModelPortaliO60279.
SMRiO60279. Positions 39-135.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117498. 9 interactions.
STRINGi9606.ENSP00000308727.

PTM databases

iPTMnetiO60279.
PhosphoSiteiO60279.
SwissPalmiO60279.

Polymorphism and mutation databases

BioMutaiSUSD5.

Proteomic databases

EPDiO60279.
MaxQBiO60279.
PaxDbiO60279.
PRIDEiO60279.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309558; ENSP00000308727; ENSG00000173705.
GeneIDi26032.
KEGGihsa:26032.
UCSCiuc003cfo.2. human.

Organism-specific databases

CTDi26032.
GeneCardsiSUSD5.
H-InvDBHIX0003154.
HGNCiHGNC:29061. SUSD5.
HPAiHPA052788.
neXtProtiNX_O60279.
PharmGKBiPA143485627.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFAC. Eukaryota.
ENOG410YBQZ. LUCA.
GeneTreeiENSGT00390000009163.
HOGENOMiHOG000154451.
HOVERGENiHBG108521.
InParanoidiO60279.
OMAiHLFWFPA.
OrthoDBiEOG7J9VP3.
PhylomeDBiO60279.
TreeFamiTF336259.

Miscellaneous databases

GenomeRNAii26032.
NextBioi47834.
PROiO60279.

Gene expression databases

BgeeiO60279.
CleanExiHS_SUSD5.
ExpressionAtlasiO60279. baseline and differential.
GenevisibleiO60279. HS.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR000538. Link_dom.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00193. Xlink. 1 hit.
[Graphical view]
SMARTiSM00445. LINK. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
SSF57535. SSF57535. 1 hit.
PROSITEiPS50963. LINK_2. 1 hit.
PS50923. SUSHI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS LEU-40 AND ASP-378.
    Tissue: Brain.
  2. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSUSD5_HUMAN
AccessioniPrimary (citable) accession number: O60279
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: April 8, 2008
Last modified: May 11, 2016
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.