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Protein

G protein-regulated inducer of neurite outgrowth 2

Gene

GPRIN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in neurite outgrowth.1 Publication

Enzyme and pathway databases

BioCyciZFISH:G66-33557-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
G protein-regulated inducer of neurite outgrowth 2
Short name:
GRIN2
Gene namesi
Name:GPRIN2
Synonyms:KIAA0514
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:23730. GPRIN2.

Pathology & Biotechi

Organism-specific databases

DisGeNETi9721.
OpenTargetsiENSG00000204175.
PharmGKBiPA162390192.

Polymorphism and mutation databases

BioMutaiGPRIN2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000507591 – 458G protein-regulated inducer of neurite outgrowth 2Add BLAST458

Proteomic databases

MaxQBiO60269.
PaxDbiO60269.
PeptideAtlasiO60269.
PRIDEiO60269.

PTM databases

iPTMnetiO60269.
PhosphoSitePlusiO60269.

Expressioni

Tissue specificityi

Expressed specifically in the cerebellum.1 Publication

Gene expression databases

BgeeiENSG00000204175.
CleanExiHS_GPRIN2.
GenevisibleiO60269. HS.

Interactioni

Subunit structurei

Interacts with activated forms of GNAO1 and GNAZ.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SFNP319472EBI-740397,EBI-476295

Protein-protein interaction databases

BioGridi115070. 14 interactors.
IntActiO60269. 9 interactors.
MINTiMINT-1439763.
STRINGi9606.ENSP00000363433.

Structurei

3D structure databases

ProteinModelPortaliO60269.
SMRiO60269.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IYCC. Eukaryota.
ENOG4111KRR. LUCA.
GeneTreeiENSGT00570000079168.
HOGENOMiHOG000112814.
InParanoidiO60269.
OMAiCKAVATS.
OrthoDBiEOG091G04VZ.
PhylomeDBiO60269.
TreeFamiTF337047.

Family and domain databases

InterProiIPR026646. GPRIN2-like/GPRIN3.
IPR032745. GRIN_C.
[Graphical view]
PANTHERiPTHR15718. PTHR15718. 1 hit.
PfamiPF15235. GRIN_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O60269-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSRPEPGP WAPLSPRLQP LSQSSSSLLG EGREQRPELR KTASSTVWQA
60 70 80 90 100
QLGEASTRPQ APEEEGNPPE SMKPARASGP KARPSAGGHW WSSTVGNVST
110 120 130 140 150
MGGSDLCRLR APSAAAMQRS HSDLVRSTQM RGHSGARKAS LSCSALGSSP
160 170 180 190 200
VHRAQLQPGG TSGQGGQAPA GLERDLAPED ETSNSAWMLG ASQLSVPPLD
210 220 230 240 250
LGDTTAHSSS AQAEPKAAEQ LATTTCHALP PAALLCGMRE VRAGGCCHAL
260 270 280 290 300
PATGILAFPK LVASVSESGL QAQHGVKIHC RLSGGLPGHS HCCAHLWGPA
310 320 330 340 350
GLVPEPGSRT KDVWTMTSAN DLAPAEASPL SAQDAGVQAA PVAACKAVAT
360 370 380 390 400
SPSLEAPAAL HVFPEVTLGS SLEEVPSPVR DVRWDAEGMT WEVYGAAVDL
410 420 430 440 450
EVLGVAIQKH LEMQFEQLQR APASEDSLSV EGRRGPLRAV MQSLRRPSCC

GCSGAAPE
Length:458
Mass (Da):47,450
Last modified:May 16, 2006 - v2
Checksum:iD6395C187FAD142D
GO

Sequence cautioni

The sequence BAA25440 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti241 – 242VR → MREVG in BAA25440 (PubMed:9628581).Curated2
Sequence conflicti241 – 242VR → MREVG in AAH11672 (PubMed:15489334).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0596605R → H.2 PublicationsCorresponds to variant rs3127817dbSNPEnsembl.1
Natural variantiVAR_05101739L → V.Corresponds to variant rs4926045dbSNPEnsembl.1
Natural variantiVAR_05966140R → H.2 PublicationsCorresponds to variant rs3127818dbSNPEnsembl.1
Natural variantiVAR_05966247V → M.2 PublicationsCorresponds to variant rs3127819dbSNPEnsembl.1
Natural variantiVAR_05966391W → R.2 PublicationsCorresponds to variant rs3127820dbSNPEnsembl.1
Natural variantiVAR_061656100T → P.Corresponds to variant rs7090312dbSNPEnsembl.1
Natural variantiVAR_051018104S → G.2 PublicationsCorresponds to variant rs3127679dbSNPEnsembl.1
Natural variantiVAR_061657202G → W.Corresponds to variant rs11204658dbSNPEnsembl.1
Natural variantiVAR_061658233A → S.Corresponds to variant rs11204659dbSNPEnsembl.1
Natural variantiVAR_061659241V → M.Corresponds to variant rs9422022dbSNPEnsembl.1
Natural variantiVAR_061660242R → G.Corresponds to variant rs3127683dbSNPEnsembl.1
Natural variantiVAR_061661328S → C.Corresponds to variant rs4445576dbSNPEnsembl.1
Natural variantiVAR_061662375V → A.1 PublicationCorresponds to variant rs3127822dbSNPEnsembl.1
Natural variantiVAR_059664400L → P.2 PublicationsCorresponds to variant rs3127823dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011086 mRNA. Translation: BAA25440.2. Different initiation.
AL645529 Genomic DNA. Translation: CAI14956.1.
BC011672 mRNA. Translation: AAH11672.1.
CCDSiCCDS73101.1.
RefSeqiNP_055511.2. NM_014696.3.
XP_005277723.1. XM_005277666.3.
XP_011538702.1. XM_011540400.2.
UniGeneiHs.523375.

Genome annotation databases

EnsembliENST00000374314; ENSP00000363433; ENSG00000204175.
ENST00000374317; ENSP00000363436; ENSG00000204175.
GeneIDi9721.
KEGGihsa:9721.
UCSCiuc057taj.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011086 mRNA. Translation: BAA25440.2. Different initiation.
AL645529 Genomic DNA. Translation: CAI14956.1.
BC011672 mRNA. Translation: AAH11672.1.
CCDSiCCDS73101.1.
RefSeqiNP_055511.2. NM_014696.3.
XP_005277723.1. XM_005277666.3.
XP_011538702.1. XM_011540400.2.
UniGeneiHs.523375.

3D structure databases

ProteinModelPortaliO60269.
SMRiO60269.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115070. 14 interactors.
IntActiO60269. 9 interactors.
MINTiMINT-1439763.
STRINGi9606.ENSP00000363433.

PTM databases

iPTMnetiO60269.
PhosphoSitePlusiO60269.

Polymorphism and mutation databases

BioMutaiGPRIN2.

Proteomic databases

MaxQBiO60269.
PaxDbiO60269.
PeptideAtlasiO60269.
PRIDEiO60269.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374314; ENSP00000363433; ENSG00000204175.
ENST00000374317; ENSP00000363436; ENSG00000204175.
GeneIDi9721.
KEGGihsa:9721.
UCSCiuc057taj.1. human.

Organism-specific databases

CTDi9721.
DisGeNETi9721.
GeneCardsiGPRIN2.
H-InvDBHIX0008795.
HGNCiHGNC:23730. GPRIN2.
MIMi611240. gene.
neXtProtiNX_O60269.
OpenTargetsiENSG00000204175.
PharmGKBiPA162390192.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYCC. Eukaryota.
ENOG4111KRR. LUCA.
GeneTreeiENSGT00570000079168.
HOGENOMiHOG000112814.
InParanoidiO60269.
OMAiCKAVATS.
OrthoDBiEOG091G04VZ.
PhylomeDBiO60269.
TreeFamiTF337047.

Enzyme and pathway databases

BioCyciZFISH:G66-33557-MONOMER.

Miscellaneous databases

GeneWikiiGPRIN2.
GenomeRNAii9721.
PROiO60269.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204175.
CleanExiHS_GPRIN2.
GenevisibleiO60269. HS.

Family and domain databases

InterProiIPR026646. GPRIN2-like/GPRIN3.
IPR032745. GRIN_C.
[Graphical view]
PANTHERiPTHR15718. PTHR15718. 1 hit.
PfamiPF15235. GRIN_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGRIN2_HUMAN
AccessioniPrimary (citable) accession number: O60269
Secondary accession number(s): Q5SVF0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 16, 2006
Last modified: November 2, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.