Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O60266

- ADCY3_HUMAN

UniProt

O60266 - ADCY3_HUMAN

Protein

Adenylate cyclase type 3

Gene

ADCY3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 146 (01 Oct 2014)
      Sequence version 3 (28 Nov 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration.

    Catalytic activityi

    ATP = 3',5'-cyclic AMP + diphosphate.

    Cofactori

    Binds 2 magnesium ions per subunit.By similarity

    Enzyme regulationi

    Activated by calcium/calmodulin.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi324 – 3241Magnesium 1PROSITE-ProRule annotation
    Metal bindingi324 – 3241Magnesium 2PROSITE-ProRule annotation
    Metal bindingi325 – 3251Magnesium 2; via carbonyl oxygenPROSITE-ProRule annotation
    Metal bindingi368 – 3681Magnesium 1PROSITE-ProRule annotation
    Metal bindingi368 – 3681Magnesium 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. adenylate cyclase activity Source: ProtInc
    2. ATP binding Source: UniProtKB-KW
    3. metal ion binding Source: UniProtKB-KW
    4. nucleotide binding Source: UniProtKB-KW
    5. phosphorus-oxygen lyase activity Source: InterPro

    GO - Biological processi

    1. activation of phospholipase C activity Source: Reactome
    2. activation of protein kinase A activity Source: Reactome
    3. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: Reactome
    4. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: Reactome
    5. cellular response to glucagon stimulus Source: Reactome
    6. cyclic nucleotide biosynthetic process Source: InterPro
    7. energy reserve metabolic process Source: Reactome
    8. epidermal growth factor receptor signaling pathway Source: Reactome
    9. fibroblast growth factor receptor signaling pathway Source: Reactome
    10. innate immune response Source: Reactome
    11. intracellular signal transduction Source: InterPro
    12. neurotrophin TRK receptor signaling pathway Source: Reactome
    13. sensory perception of smell Source: UniProtKB-KW
    14. signal transduction Source: Reactome
    15. small molecule metabolic process Source: Reactome
    16. synaptic transmission Source: Reactome
    17. transmembrane transport Source: Reactome
    18. water transport Source: Reactome

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    cAMP biosynthesis, Olfaction, Sensory transduction

    Keywords - Ligandi

    ATP-binding, Calmodulin-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi4.6.1.1. 2681.
    ReactomeiREACT_15312. Adenylate cyclase activating pathway.
    REACT_15333. Adenylate cyclase inhibitory pathway.
    REACT_15530. PKA activation.
    REACT_1665. Glucagon signaling in metabolic regulation.
    REACT_19231. G alpha (i) signalling events.
    REACT_19327. G alpha (s) signalling events.
    REACT_19333. G alpha (z) signalling events.
    REACT_1946. PKA activation in glucagon signalling.
    REACT_20625. CREB phosphorylation through the activation of Adenylate Cyclase.
    REACT_24023. Regulation of water balance by renal Aquaporins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adenylate cyclase type 3 (EC:4.6.1.1)
    Alternative name(s):
    ATP pyrophosphate-lyase 3
    Adenylate cyclase type III
    Short name:
    AC-III
    Adenylate cyclase, olfactive type
    Adenylyl cyclase 3
    Short name:
    AC3
    Gene namesi
    Name:ADCY3
    Synonyms:KIAA0511
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:234. ADCY3.

    Subcellular locationi

    GO - Cellular componenti

    1. cilium Source: Ensembl
    2. cytoplasm Source: UniProtKB
    3. integral component of membrane Source: UniProtKB-KW
    4. integral component of plasma membrane Source: ProtInc
    5. membrane Source: UniProtKB
    6. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164741137.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11441144Adenylate cyclase type 3PRO_0000195687Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi736 – 7361N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiO60266.
    PaxDbiO60266.
    PRIDEiO60266.

    PTM databases

    PhosphoSiteiO60266.

    Expressioni

    Tissue specificityi

    Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, and skeletal muscle.

    Gene expression databases

    ArrayExpressiO60266.
    BgeeiO60266.
    CleanExiHS_ADCY3.
    GenevestigatoriO60266.

    Organism-specific databases

    HPAiCAB010223.
    HPA051172.

    Interactioni

    Protein-protein interaction databases

    BioGridi106623. 3 interactions.
    IntActiO60266. 1 interaction.
    MINTiMINT-7290325.
    STRINGi9606.ENSP00000260600.

    Structurei

    3D structure databases

    ProteinModelPortaliO60266.
    SMRiO60266. Positions 307-493, 912-1098.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7979CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini402 – 632231CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini854 – 1144291CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei80 – 10021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei105 – 12521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei139 – 15921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei173 – 19321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei226 – 24621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei381 – 40121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei633 – 65321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei664 – 68421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei708 – 72821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei754 – 77421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei775 – 79521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei833 – 85321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation
    Contains 2 guanylate cyclase domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2114.
    HOVERGENiHBG050458.
    InParanoidiO60266.
    KOiK08043.
    OMAiVTLMNIN.
    OrthoDBiEOG7B8S30.
    PhylomeDBiO60266.
    TreeFamiTF313845.

    Family and domain databases

    Gene3Di3.30.70.1230. 2 hits.
    InterProiIPR001054. A/G_cyclase.
    IPR018297. A/G_cyclase_CS.
    [Graphical view]
    PfamiPF00211. Guanylate_cyc. 2 hits.
    [Graphical view]
    SMARTiSM00044. CYCc. 2 hits.
    [Graphical view]
    SUPFAMiSSF55073. SSF55073. 2 hits.
    PROSITEiPS00452. GUANYLATE_CYCLASE_1. 2 hits.
    PS50125. GUANYLATE_CYCLASE_2. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O60266-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPRNQGFSEP EYSAEYSAEY SVSLPSDPDR GVGRTHEISV RNSGSCLCLP     50
    RFMRLTFVPE SLENLYQTYF KRQRHETLLV LVVFAALFDC YVVVMCAVVF 100
    SSDKLASLAV AGIGLVLDII LFVLCKKGLL PDRVTRRVLP YVLWLLITAQ 150
    IFSYLGLNFA RAHAASDTVG WQVFFVFSFF ITLPLSLSPI VIISVVSCVV 200
    HTLVLGVTVA QQQQEELKGM QLLREILANV FLYLCAIAVG IMSYYMADRK 250
    HRKAFLEARQ SLEVKMNLEE QSQQQENLML SILPKHVADE MLKDMKKDES 300
    QKDQQQFNTM YMYRHENVSI LFADIVGFTQ LSSACSAQEL VKLLNELFAR 350
    FDKLAAKYHQ LRIKILGDCY YCICGLPDYR EDHAVCSILM GLAMVEAISY 400
    VREKTKTGVD MRVGVHTGTV LGGVLGQKRW QYDVWSTDVT VANKMEAGGI 450
    PGRVHISQST MDCLKGEFDV EPGDGGSRCD YLEEKGIETY LIIASKPEVK 500
    KTATQNGLNG SALPNGAPAS SKSSSPALIE TKEPNGSAHS SGSTSEKPEE 550
    QDAQADNPSF PNPRRRLRLQ DLADRVVDAS EDEHELNQLL NEALLERESA 600
    QVVKKRNTFL LSMRFMDPEM ETRYSVEKEK QSGAAFSCSC VVLLCTALVE 650
    ILIDPWLMTN YVTFMVGEIL LLILTICSLA AIFPRAFPKK LVAFSTWIDR 700
    TRWARNTWAM LAIFILVMAN VVDMLSCLQY YTGPSNATAG METEGSCLEN 750
    PKYYNYVAVL SLIATIMLVQ VSHMVKLTLM LLVAGAVATI NLYAWRPVFD 800
    EYDHKRFREH DLPMVALEQM QGFNPGLNGT DRLPLVPSKY SMTVMVFLMM 850
    LSFYYFSRHV EKLARTLFLW KIEVHDQKER VYEMRRWNEA LVTNMLPEHV 900
    ARHFLGSKKR DEELYSQTYD EIGVMFASLP NFADFYTEES INNGGIECLR 950
    FLNEIISDFD SLLDNPKFRV ITKIKTIGST YMAASGVTPD VNTNGFASSN 1000
    KEDKSERERW QHLADLADFA LAMKDTLTNI NNQSFNNFML RIGMNKGGVL 1050
    AGVIGARKPH YDIWGNTVNV ASRMESTGVM GNIQVVEETQ VILREYGFRF 1100
    VRRGPIFVKG KGELLTFFLK GRDKLATFPN GPSVTLPHQV VDNS 1144
    Length:1,144
    Mass (Da):128,960
    Last modified:November 28, 2006 - v3
    Checksum:iB75D39DD0A8ACA12
    GO
    Isoform 2 (identifier: O60266-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-389: Missing.
         452-452: G → GGSKIEERLYSCVVAPTLRLRWE
         725-770: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:731
    Mass (Da):82,289
    Checksum:i960E91B8B64A5C8F
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti107 – 1071S → P.1 Publication
    Corresponds to variant rs11676272 [ dbSNP | Ensembl ].
    VAR_048248

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 389389Missing in isoform 2. 1 PublicationVSP_055813Add
    BLAST
    Alternative sequencei452 – 4521G → GGSKIEERLYSCVVAPTLRL RWE in isoform 2. 1 PublicationVSP_055814
    Alternative sequencei725 – 77046Missing in isoform 2. 1 PublicationVSP_055815Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF033861 mRNA. Translation: AAD13403.1.
    AK095173 mRNA. Translation: BAG52998.1.
    AC012073 Genomic DNA. Translation: AAY14787.1.
    BC126235 mRNA. Translation: AAI26236.1.
    AB011083 mRNA. Translation: BAA25437.1.
    CCDSiCCDS1715.1.
    RefSeqiNP_004027.2. NM_004036.3.
    XP_005264162.1. XM_005264105.1.
    UniGeneiHs.467898.

    Genome annotation databases

    EnsembliENST00000260600; ENSP00000260600; ENSG00000138031. [O60266-1]
    ENST00000405392; ENSP00000384484; ENSG00000138031. [O60266-2]
    GeneIDi109.
    KEGGihsa:109.
    UCSCiuc002rfs.4. human.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF033861 mRNA. Translation: AAD13403.1 .
    AK095173 mRNA. Translation: BAG52998.1 .
    AC012073 Genomic DNA. Translation: AAY14787.1 .
    BC126235 mRNA. Translation: AAI26236.1 .
    AB011083 mRNA. Translation: BAA25437.1 .
    CCDSi CCDS1715.1.
    RefSeqi NP_004027.2. NM_004036.3.
    XP_005264162.1. XM_005264105.1.
    UniGenei Hs.467898.

    3D structure databases

    ProteinModelPortali O60266.
    SMRi O60266. Positions 307-493, 912-1098.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106623. 3 interactions.
    IntActi O60266. 1 interaction.
    MINTi MINT-7290325.
    STRINGi 9606.ENSP00000260600.

    Chemistry

    BindingDBi O60266.
    ChEMBLi CHEMBL2097167.

    PTM databases

    PhosphoSitei O60266.

    Proteomic databases

    MaxQBi O60266.
    PaxDbi O60266.
    PRIDEi O60266.

    Protocols and materials databases

    DNASUi 109.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000260600 ; ENSP00000260600 ; ENSG00000138031 . [O60266-1 ]
    ENST00000405392 ; ENSP00000384484 ; ENSG00000138031 . [O60266-2 ]
    GeneIDi 109.
    KEGGi hsa:109.
    UCSCi uc002rfs.4. human.

    Organism-specific databases

    CTDi 109.
    GeneCardsi GC02M025042.
    H-InvDB HIX0001880.
    HIX0030389.
    HIX0161886.
    HGNCi HGNC:234. ADCY3.
    HPAi CAB010223.
    HPA051172.
    MIMi 600291. gene.
    neXtProti NX_O60266.
    PharmGKBi PA164741137.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2114.
    HOVERGENi HBG050458.
    InParanoidi O60266.
    KOi K08043.
    OMAi VTLMNIN.
    OrthoDBi EOG7B8S30.
    PhylomeDBi O60266.
    TreeFami TF313845.

    Enzyme and pathway databases

    BRENDAi 4.6.1.1. 2681.
    Reactomei REACT_15312. Adenylate cyclase activating pathway.
    REACT_15333. Adenylate cyclase inhibitory pathway.
    REACT_15530. PKA activation.
    REACT_1665. Glucagon signaling in metabolic regulation.
    REACT_19231. G alpha (i) signalling events.
    REACT_19327. G alpha (s) signalling events.
    REACT_19333. G alpha (z) signalling events.
    REACT_1946. PKA activation in glucagon signalling.
    REACT_20625. CREB phosphorylation through the activation of Adenylate Cyclase.
    REACT_24023. Regulation of water balance by renal Aquaporins.

    Miscellaneous databases

    GeneWikii ADCY3.
    GenomeRNAii 109.
    NextBioi 423.
    PROi O60266.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O60266.
    Bgeei O60266.
    CleanExi HS_ADCY3.
    Genevestigatori O60266.

    Family and domain databases

    Gene3Di 3.30.70.1230. 2 hits.
    InterProi IPR001054. A/G_cyclase.
    IPR018297. A/G_cyclase_CS.
    [Graphical view ]
    Pfami PF00211. Guanylate_cyc. 2 hits.
    [Graphical view ]
    SMARTi SM00044. CYCc. 2 hits.
    [Graphical view ]
    SUPFAMi SSF55073. SSF55073. 2 hits.
    PROSITEi PS00452. GUANYLATE_CYCLASE_1. 2 hits.
    PS50125. GUANYLATE_CYCLASE_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of a full-length cDNA for human type 3 adenylyl cyclase and its expression in human islets."
      Yang B., He B., Abdel-Halim S.M., Tibell A., Brendel M.D., Bretzel R.G., Efendic S., Hillert J.
      Biochem. Biophys. Res. Commun. 254:548-551(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT PRO-107.
      Tissue: Fetal brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Substantia nigra.
    3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 212-1144 (ISOFORM 1).
      Tissue: Brain.
    6. "A novel adenylyl cyclase sequence cloned from the human erythroleukemia cell line."
      Hellevuo K., Yoshimura M., Kao M., Hoffman P.L., Cooper D.M.F., Tabakoff B.
      Biochem. Biophys. Res. Commun. 192:311-318(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 984-1060 (ISOFORM 1/2).

    Entry informationi

    Entry nameiADCY3_HUMAN
    AccessioniPrimary (citable) accession number: O60266
    Secondary accession number(s): B3KT86, Q53T54, Q9UDB1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: November 28, 2006
    Last modified: October 1, 2014
    This is version 146 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3