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O60266 (ADCY3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 142. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Adenylate cyclase type 3

EC=4.6.1.1
Alternative name(s):
ATP pyrophosphate-lyase 3
Adenylate cyclase type III
Short name=AC-III
Adenylate cyclase, olfactive type
Adenylyl cyclase 3
Short name=AC3
Gene names
Name:ADCY3
Synonyms:KIAA0511
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1144 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration.

Catalytic activity

ATP = 3',5'-cyclic AMP + diphosphate.

Cofactor

Binds 2 magnesium ions per subunit By similarity.

Enzyme regulation

Activated by calcium/calmodulin.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, and skeletal muscle.

Sequence similarities

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Contains 2 guanylate cyclase domains.

Ontologies

Keywords
   Biological processcAMP biosynthesis
Olfaction
Sensory transduction
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainRepeat
Transmembrane
Transmembrane helix
   LigandATP-binding
Calmodulin-binding
Magnesium
Metal-binding
Nucleotide-binding
   Molecular functionLyase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processactivation of phospholipase C activity

Traceable author statement. Source: Reactome

activation of protein kinase A activity

Traceable author statement. Source: Reactome

adenylate cyclase-activating G-protein coupled receptor signaling pathway

Traceable author statement. Source: Reactome

adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway

Traceable author statement. Source: Reactome

cellular response to glucagon stimulus

Traceable author statement. Source: Reactome

energy reserve metabolic process

Traceable author statement. Source: Reactome

epidermal growth factor receptor signaling pathway

Traceable author statement. Source: Reactome

fibroblast growth factor receptor signaling pathway

Traceable author statement. Source: Reactome

innate immune response

Traceable author statement. Source: Reactome

intracellular signal transduction

Inferred from electronic annotation. Source: InterPro

neurotrophin TRK receptor signaling pathway

Traceable author statement. Source: Reactome

sensory perception of smell

Inferred from electronic annotation. Source: UniProtKB-KW

signal transduction

Traceable author statement. Source: Reactome

small molecule metabolic process

Traceable author statement. Source: Reactome

synaptic transmission

Traceable author statement. Source: Reactome

transmembrane transport

Traceable author statement. Source: Reactome

water transport

Traceable author statement. Source: Reactome

   Cellular_componentcilium

Inferred from electronic annotation. Source: Ensembl

cytoplasm

Inferred from direct assay PubMed 11549699. Source: UniProtKB

integral component of plasma membrane

Traceable author statement Ref.1. Source: ProtInc

plasma membrane

Inferred from direct assay PubMed 11549699. Source: UniProtKB

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

adenylate cyclase activity

Traceable author statement Ref.1. Source: ProtInc

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11441144Adenylate cyclase type 3
PRO_0000195687

Regions

Topological domain1 – 7979Cytoplasmic Potential
Transmembrane80 – 10021Helical; Potential
Transmembrane105 – 12521Helical; Potential
Transmembrane139 – 15921Helical; Potential
Transmembrane173 – 19321Helical; Potential
Transmembrane226 – 24621Helical; Potential
Transmembrane381 – 40121Helical; Potential
Topological domain402 – 632231Cytoplasmic Potential
Transmembrane633 – 65321Helical; Potential
Transmembrane664 – 68421Helical; Potential
Transmembrane708 – 72821Helical; Potential
Transmembrane754 – 77421Helical; Potential
Transmembrane775 – 79521Helical; Potential
Transmembrane833 – 85321Helical; Potential
Topological domain854 – 1144291Cytoplasmic Potential

Sites

Metal binding3241Magnesium 1 By similarity
Metal binding3241Magnesium 2 By similarity
Metal binding3251Magnesium 2; via carbonyl oxygen By similarity
Metal binding3681Magnesium 1 By similarity
Metal binding3681Magnesium 2 By similarity

Amino acid modifications

Glycosylation7361N-linked (GlcNAc...) Potential

Natural variations

Natural variant1071S → P. Ref.1
Corresponds to variant rs11676272 [ dbSNP | Ensembl ].
VAR_048248

Sequences

Sequence LengthMass (Da)Tools
O60266 [UniParc].

Last modified November 28, 2006. Version 3.
Checksum: B75D39DD0A8ACA12

FASTA1,144128,960
        10         20         30         40         50         60 
MPRNQGFSEP EYSAEYSAEY SVSLPSDPDR GVGRTHEISV RNSGSCLCLP RFMRLTFVPE 

        70         80         90        100        110        120 
SLENLYQTYF KRQRHETLLV LVVFAALFDC YVVVMCAVVF SSDKLASLAV AGIGLVLDII 

       130        140        150        160        170        180 
LFVLCKKGLL PDRVTRRVLP YVLWLLITAQ IFSYLGLNFA RAHAASDTVG WQVFFVFSFF 

       190        200        210        220        230        240 
ITLPLSLSPI VIISVVSCVV HTLVLGVTVA QQQQEELKGM QLLREILANV FLYLCAIAVG 

       250        260        270        280        290        300 
IMSYYMADRK HRKAFLEARQ SLEVKMNLEE QSQQQENLML SILPKHVADE MLKDMKKDES 

       310        320        330        340        350        360 
QKDQQQFNTM YMYRHENVSI LFADIVGFTQ LSSACSAQEL VKLLNELFAR FDKLAAKYHQ 

       370        380        390        400        410        420 
LRIKILGDCY YCICGLPDYR EDHAVCSILM GLAMVEAISY VREKTKTGVD MRVGVHTGTV 

       430        440        450        460        470        480 
LGGVLGQKRW QYDVWSTDVT VANKMEAGGI PGRVHISQST MDCLKGEFDV EPGDGGSRCD 

       490        500        510        520        530        540 
YLEEKGIETY LIIASKPEVK KTATQNGLNG SALPNGAPAS SKSSSPALIE TKEPNGSAHS 

       550        560        570        580        590        600 
SGSTSEKPEE QDAQADNPSF PNPRRRLRLQ DLADRVVDAS EDEHELNQLL NEALLERESA 

       610        620        630        640        650        660 
QVVKKRNTFL LSMRFMDPEM ETRYSVEKEK QSGAAFSCSC VVLLCTALVE ILIDPWLMTN 

       670        680        690        700        710        720 
YVTFMVGEIL LLILTICSLA AIFPRAFPKK LVAFSTWIDR TRWARNTWAM LAIFILVMAN 

       730        740        750        760        770        780 
VVDMLSCLQY YTGPSNATAG METEGSCLEN PKYYNYVAVL SLIATIMLVQ VSHMVKLTLM 

       790        800        810        820        830        840 
LLVAGAVATI NLYAWRPVFD EYDHKRFREH DLPMVALEQM QGFNPGLNGT DRLPLVPSKY 

       850        860        870        880        890        900 
SMTVMVFLMM LSFYYFSRHV EKLARTLFLW KIEVHDQKER VYEMRRWNEA LVTNMLPEHV 

       910        920        930        940        950        960 
ARHFLGSKKR DEELYSQTYD EIGVMFASLP NFADFYTEES INNGGIECLR FLNEIISDFD 

       970        980        990       1000       1010       1020 
SLLDNPKFRV ITKIKTIGST YMAASGVTPD VNTNGFASSN KEDKSERERW QHLADLADFA 

      1030       1040       1050       1060       1070       1080 
LAMKDTLTNI NNQSFNNFML RIGMNKGGVL AGVIGARKPH YDIWGNTVNV ASRMESTGVM 

      1090       1100       1110       1120       1130       1140 
GNIQVVEETQ VILREYGFRF VRRGPIFVKG KGELLTFFLK GRDKLATFPN GPSVTLPHQV 


VDNS 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of a full-length cDNA for human type 3 adenylyl cyclase and its expression in human islets."
Yang B., He B., Abdel-Halim S.M., Tibell A., Brendel M.D., Bretzel R.G., Efendic S., Hillert J.
Biochem. Biophys. Res. Commun. 254:548-551(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PRO-107.
Tissue: Fetal brain.
[2]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 212-1144.
Tissue: Brain.
[5]"A novel adenylyl cyclase sequence cloned from the human erythroleukemia cell line."
Hellevuo K., Yoshimura M., Kao M., Hoffman P.L., Cooper D.M.F., Tabakoff B.
Biochem. Biophys. Res. Commun. 192:311-318(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 984-1060.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF033861 mRNA. Translation: AAD13403.1.
AC012073 Genomic DNA. Translation: AAY14787.1.
BC126235 mRNA. Translation: AAI26236.1.
AB011083 mRNA. Translation: BAA25437.1.
RefSeqNP_004027.2. NM_004036.3.
XP_005264162.1. XM_005264105.1.
UniGeneHs.467898.

3D structure databases

ProteinModelPortalO60266.
SMRO60266. Positions 307-493, 912-1098.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid106623. 2 interactions.
IntActO60266. 1 interaction.
MINTMINT-7290325.
STRING9606.ENSP00000260600.

Chemistry

BindingDBO60266.
ChEMBLCHEMBL2097167.

PTM databases

PhosphoSiteO60266.

Proteomic databases

PaxDbO60266.
PRIDEO60266.

Protocols and materials databases

DNASU109.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000260600; ENSP00000260600; ENSG00000138031.
GeneID109.
KEGGhsa:109.
UCSCuc002rfs.4. human.

Organism-specific databases

CTD109.
GeneCardsGC02M025042.
H-InvDBHIX0001880.
HIX0030389.
HIX0161886.
HGNCHGNC:234. ADCY3.
HPACAB010223.
HPA051172.
MIM600291. gene.
neXtProtNX_O60266.
PharmGKBPA164741137.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2114.
HOVERGENHBG050458.
InParanoidO60266.
KOK08043.
OMAVTLMNIN.
OrthoDBEOG7B8S30.
PhylomeDBO60266.
TreeFamTF313845.

Enzyme and pathway databases

BRENDA4.6.1.1. 2681.
ReactomeREACT_111102. Signal Transduction.
REACT_111217. Metabolism.
REACT_116125. Disease.
REACT_13685. Neuronal System.
REACT_15518. Transmembrane transport of small molecules.
REACT_6900. Immune System.

Gene expression databases

ArrayExpressO60266.
BgeeO60266.
CleanExHS_ADCY3.
GenevestigatorO60266.

Family and domain databases

Gene3D3.30.70.1230. 2 hits.
InterProIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
[Graphical view]
PfamPF00211. Guanylate_cyc. 2 hits.
[Graphical view]
SMARTSM00044. CYCc. 2 hits.
[Graphical view]
SUPFAMSSF55073. SSF55073. 2 hits.
PROSITEPS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiADCY3.
GenomeRNAi109.
NextBio423.
PROO60266.
SOURCESearch...

Entry information

Entry nameADCY3_HUMAN
AccessionPrimary (citable) accession number: O60266
Secondary accession number(s): Q53T54, Q9UDB1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 28, 2006
Last modified: April 16, 2014
This is version 142 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM