Reviewed, UniProtKB/Swiss-Prot O60266 (ADCY3_HUMAN)

Names and origin

Protein names

Recommended name:
    Adenylate cyclase type 3
    EC=4.6.1.1
Alternative name(s):
    Adenylate cyclase type III
      Short name=AC-III
    ATP pyrophosphate-lyase 3
    Adenylyl cyclase 3
      Short name=AC3
    Adenylate cyclase, olfactive type

Gene names

Name:	ADCY3
Synonyms:	KIAA0511

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1144 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration.
Catalytic activity	ATP = 3',5'-cyclic AMP + diphosphate.
Cofactor	Binds 2 magnesium ions per subunit By similarity.
Enzyme regulation	Activated by calcium/calmodulin.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, and skeletal muscle.
Sequence similarities	Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Contains 2 guanylate cyclase domains.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction cAMP biosynthesis
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Repeat Transmembrane
Ligand	ATP-binding Calmodulin-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Lyase
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	activation of adenylate cyclase activity by G-protein signaling pathway Inferred from Experiment. Source: Reactome activation of protein kinase A activity Inferred from Experiment. Source: Reactome cAMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW hormone-mediated signaling pathway Inferred from Experiment. Source: Reactome inhibition of adenylate cyclase activity by G-protein signaling pathway Inferred from Experiment. Source: Reactome sensory perception of smell Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to plasma membrane Ref.1 Traceable author statement. Source: ProtInc
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW calmodulin binding Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1144	1144	Adenylate cyclase type 3		PRO_0000195687
Regions
	Topological domain	1 – 79	79	Cytoplasmic Potential
	Transmembrane	80 – 100	21	Potential
	Transmembrane	105 – 125	21	Potential
	Transmembrane	139 – 159	21	Potential
	Transmembrane	173 – 193	21	Potential
	Transmembrane	226 – 246	21	Potential
	Transmembrane	381 – 401	21	Potential
	Topological domain	402 – 632	231	Cytoplasmic Potential
	Transmembrane	633 – 653	21	Potential
	Transmembrane	664 – 684	21	Potential
	Transmembrane	708 – 728	21	Potential
	Transmembrane	754 – 774	21	Potential
	Transmembrane	775 – 795	21	Potential
	Transmembrane	833 – 853	21	Potential
	Topological domain	854 – 1144	291	Cytoplasmic Potential
Sites
	Metal binding	324	1	Magnesium 1 By similarity
	Metal binding	324	1	Magnesium 2 By similarity
	Metal binding	325	1	Magnesium 2; via carbonyl oxygen By similarity
	Metal binding	368	1	Magnesium 1 By similarity
	Metal binding	368	1	Magnesium 2 By similarity
Amino acid modifications
	Glycosylation	736	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	107	1	S → P: dbSNP rs11676272. Ref.1		VAR_048248

Sequences

	Sequence		Length	Mass (Da)
	O60266-1 [UniParc]. Last modified November 28, 2006. Version 3. Checksum: B75D39DD0A8ACA12	FASTA	1,144	128,960
	10 20 30 40 50 60 MPRNQGFSEP EYSAEYSAEY SVSLPSDPDR GVGRTHEISV RNSGSCLCLP RFMRLTFVPE 70 80 90 100 110 120 SLENLYQTYF KRQRHETLLV LVVFAALFDC YVVVMCAVVF SSDKLASLAV AGIGLVLDII 130 140 150 160 170 180 LFVLCKKGLL PDRVTRRVLP YVLWLLITAQ IFSYLGLNFA RAHAASDTVG WQVFFVFSFF 190 200 210 220 230 240 ITLPLSLSPI VIISVVSCVV HTLVLGVTVA QQQQEELKGM QLLREILANV FLYLCAIAVG 250 260 270 280 290 300 IMSYYMADRK HRKAFLEARQ SLEVKMNLEE QSQQQENLML SILPKHVADE MLKDMKKDES 310 320 330 340 350 360 QKDQQQFNTM YMYRHENVSI LFADIVGFTQ LSSACSAQEL VKLLNELFAR FDKLAAKYHQ 370 380 390 400 410 420 LRIKILGDCY YCICGLPDYR EDHAVCSILM GLAMVEAISY VREKTKTGVD MRVGVHTGTV 430 440 450 460 470 480 LGGVLGQKRW QYDVWSTDVT VANKMEAGGI PGRVHISQST MDCLKGEFDV EPGDGGSRCD 490 500 510 520 530 540 YLEEKGIETY LIIASKPEVK KTATQNGLNG SALPNGAPAS SKSSSPALIE TKEPNGSAHS 550 560 570 580 590 600 SGSTSEKPEE QDAQADNPSF PNPRRRLRLQ DLADRVVDAS EDEHELNQLL NEALLERESA 610 620 630 640 650 660 QVVKKRNTFL LSMRFMDPEM ETRYSVEKEK QSGAAFSCSC VVLLCTALVE ILIDPWLMTN 670 680 690 700 710 720 YVTFMVGEIL LLILTICSLA AIFPRAFPKK LVAFSTWIDR TRWARNTWAM LAIFILVMAN 730 740 750 760 770 780 VVDMLSCLQY YTGPSNATAG METEGSCLEN PKYYNYVAVL SLIATIMLVQ VSHMVKLTLM 790 800 810 820 830 840 LLVAGAVATI NLYAWRPVFD EYDHKRFREH DLPMVALEQM QGFNPGLNGT DRLPLVPSKY 850 860 870 880 890 900 SMTVMVFLMM LSFYYFSRHV EKLARTLFLW KIEVHDQKER VYEMRRWNEA LVTNMLPEHV 910 920 930 940 950 960 ARHFLGSKKR DEELYSQTYD EIGVMFASLP NFADFYTEES INNGGIECLR FLNEIISDFD 970 980 990 1000 1010 1020 SLLDNPKFRV ITKIKTIGST YMAASGVTPD VNTNGFASSN KEDKSERERW QHLADLADFA 1030 1040 1050 1060 1070 1080 LAMKDTLTNI NNQSFNNFML RIGMNKGGVL AGVIGARKPH YDIWGNTVNV ASRMESTGVM 1090 1100 1110 1120 1130 1140 GNIQVVEETQ VILREYGFRF VRRGPIFVKG KGELLTFFLK GRDKLATFPN GPSVTLPHQV VDNS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of a full-length cDNA for human type 3 adenylyl cyclase and its expression in human islets." Yang B., He B., Abdel-Halim S.M., Tibell A., Brendel M.D., Bretzel R.G., Efendic S., Hillert J. Biochem. Biophys. Res. Commun. 254:548-551(1999) [PubMed: 9920776] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PRO-107. Tissue: Fetal brain.
[2]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:31-39(1998) [PubMed: 9628581] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 212-1144. Tissue: Brain.
[5]	"A novel adenylyl cyclase sequence cloned from the human erythroleukemia cell line." Hellevuo K., Yoshimura M., Kao M., Hoffman P.L., Cooper D.M.F., Tabakoff B. Biochem. Biophys. Res. Commun. 192:311-318(1993) [PubMed: 8476432] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 984-1060.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF033861 mRNA. Translation: AAD13403.1. AC012073 Genomic DNA. Translation: AAY14787.1. BC126235 mRNA. Translation: AAI26236.1. AB011083 mRNA. Translation: BAA25437.1.
IPI	IPI00028513.
RefSeq	NP_004027.2.
UniGene	Hs.467898
3D structure databases
SMR	O60266. Positions 307-493, 914-1101.
ModBase	Search...
Protein-protein interaction databases
STRING	O60266.
PTM databases
PhosphoSite	O60266.
Proteomic databases
PRIDE	O60266.
Genome annotation databases
Ensembl	ENST00000260600; ENSP00000260600; ENSG00000138031; Homo sapiens. [Genome view]
GeneID	109.
KEGG	hsa:109.
UCSC	uc002rfs.2. human.
Organism-specific databases
CTD	109.
GeneCards	GC02M024953.
H-InvDB	HIX0001880. HIX0030389.
HGNC	HGNC:234. ADCY3.
HPA	CAB010223.
MIM	600291. gene.
PharmGKB	PA26.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG12287.
HOVERGEN	O60266.
InParanoid	O60266.
OMA	ESAQVVK.
OrthoDB	EOG9VMJ0M.
PhylomeDB	O60266.
Enzyme and pathway databases
BRENDA	4.6.1.1. 247.
Pathway_Interaction_DB	endothelinpathway. Endothelins. lysophospholipid_pathway. LPA receptor mediated events. lpa4_pathway. LPA4-mediated signaling events.
Reactome	REACT_11061. Signalling by NGF. REACT_13685. Synaptic Transmission. REACT_14797. Signaling by GPCR. REACT_1505. Integration of energy metabolism. REACT_15295. Opioid Signalling.
Gene expression databases
ArrayExpress	O60266.
Bgee	O60266.
CleanEx	HS_ADCY3.
Genevestigator	O60266.
GermOnline	ENSG00000138031. Homo sapiens.
Family and domain databases
InterPro	IPR001054. A/G_cyclase. IPR018297. A/G_cyclase_CS. [Graphical view]
Gene3D	G3DSA:3.30.70.1230. A/G_cyclase. 2 hits.
Pfam	PF00211. Guanylate_cyc. 2 hits. [Graphical view]
SMART	SM00044. CYCc. 2 hits. [Graphical view]
PROSITE	PS00452. GUANYLATE_CYCLASE_1. 2 hits. PS50125. GUANYLATE_CYCLASE_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	423.
SOURCE	Search...

Entry information

Entry name

ADCY3_HUMAN

Accession

Primary (citable) accession number: O60266
Secondary accession number(s): Q53T54, Q9UDB1

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	November 28, 2006
Last modified:	February 9, 2010
This is version 102 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.