Reviewed, UniProtKB/Swiss-Prot O60262 (GBG7_HUMAN)

Names and origin

Protein names

Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7

Gene names

Name:	GNG7
Synonyms:	GNGT7

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	68 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Subunit structure	G proteins are composed of 3 units, alpha, beta and gamma.
Subcellular location	Cell membrane; Lipid-anchor; Cytoplasmic side Potential.
Tissue specificity	Expressed in a variety of tissues. Down-regulated in pancreatic cancer.
Sequence similarities	Belongs to the G protein gamma family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Molecular function	Transducer
PTM	Acetylation Lipoprotein Methylation Prenylation
Gene Ontology (GO)
Biological process	G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: InterPro hormone-mediated signaling Inferred from Experiment. Source: Reactome regulation of G-protein coupled receptor protein signaling pathway Ref.1 Traceable author statement. Source: ProtInc
Cellular component	heterotrimeric G-protein complex Inferred from electronic annotation. Source: InterPro
Molecular function	signal transducer activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 65	64	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7		PRO_0000012635
	Propeptide	66 – 68	3	Removed in mature form By similarity		PRO_0000012636
Amino acid modifications
	Modified residue	2	1	N-acetylserine By similarity
	Modified residue	65	1	Cysteine methyl ester By similarity
	Lipidation	65	1	S-geranylgeranyl cysteine By similarity

Sequences

	Sequence		Length	Mass (Da)
	O60262-1 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 704133C7BEC7FD72	FASTA	68	7,522
	10 20 30 40 50 60 MSATNNIAQA RKLVEQLRIE AGIERIKVSK AASDLMSYCE QHARNDPLLV GVPASENPFK DKKPCIIL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and cloning of human G-protein gamma 7, down-regulated in pancreatic cancer." Shibata K., Mori M., Tanaka S., Kitano S., Akiyoshi T. Biochem. Biophys. Res. Commun. 246:205-209(1998) [PubMed: 9600093] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Puhl H.L. III, Ikeda S.R., Aronstam R.S. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Amygdala.
[4]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed: 15057824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin and Uterus.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB010414 mRNA. Translation: BAA28348.1. AF493874 mRNA. Translation: AAM12588.1. AK311750 mRNA. Translation: BAG34693.1. AC005512 Genomic DNA. Translation: AAC32595.1. BC014466 mRNA. Translation: AAH14466.1. BC053630 mRNA. Translation: AAH53630.1.
IPI	IPI00028509.
PIR	JW0050.
RefSeq	NP_443079.1.
UniGene	Hs.515544
3D structure databases
HSSP	HSSP built from PDB template 1GG2 based on UniProtKB P16874.
SMR	O60262. Positions 4-63.
ModBase	Search...
Protein-protein interaction databases
IntAct	O60262. 2 interactions.
Proteomic databases
PeptideAtlas	O60262.
PRIDE	O60262.
Genome annotation databases
Ensembl	ENSG00000213611. Homo sapiens. [Contig view]
GeneID	2788.
KEGG	hsa:2788.
Organism-specific databases
GeneCards	GC19M002465.
H-InvDB	HIX0020378.
HGNC	HGNC:4410. GNG7.
MIM	604430. gene.
PharmGKB	PA28789.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	O60262.
OMA	O60262. NNVAQAR.
Enzyme and pathway databases
Reactome	REACT_1505. Integration of energy metabolism.
Gene expression databases
CleanEx	HS_GNG7.
GermOnline	ENSG00000176533. Homo sapiens.
Family and domain databases
InterPro	IPR015898. G-protein_gamma-like. IPR001770. Gprotein-gamma. [Graphical view]
PANTHER	PTHR13809. Gprotein-gamma. 1 hit.
Pfam	PF00631. G-gamma. 1 hit. [Graphical view]
PRINTS	PR00321. GPROTEING.
ProDom	PD003783. G-gamma. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00224. GGL. 1 hit. [Graphical view]
PROSITE	PS50058. G_PROTEIN_GAMMA. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	10987.
SOURCE	Search...

Entry information

Entry name

GBG7_HUMAN

Accession

Primary (citable) accession number: O60262
Secondary accession number(s): B2R496

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	August 1, 1998
Last modified:	June 16, 2009
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)