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Reviewed, UniProtKB/Swiss-Prot O60262 (GBG7_HUMAN)

Last modified November 25, 2008. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
Gene names
Name: GNG7
Synonyms: GNGT7
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length68 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Subunit structure

G proteins are composed of 3 units, alpha, beta and gamma.

Subcellular location

Cell membrane; Lipid-anchor; Cytoplasmic sidePotential.

Tissue specificity

Expressed in a variety of tissues. Down-regulated in pancreatic cancer.

Sequence similarities

Belongs to the G protein gamma family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 6564Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
PRO_0000012635
Propeptide66 – 683Removed in mature form By similarity
PRO_0000012636

Amino acid modifications

Lipidation651S-geranylgeranyl cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
O60262-1 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 704133C7BEC7FD72

FASTA687,522
        10         20         30         40         50         60 
MSATNNIAQA RKLVEQLRIE AGIERIKVSK AASDLMSYCE QHARNDPLLV GVPASENPFK 


DKKPCIIL 

« Hide

References

« Hide 'large scale' references
[1]"Identification and cloning of human G-protein gamma 7, down-regulated in pancreatic cancer."
Shibata K., Mori M., Tanaka S., Kitano S., Akiyoshi T.
Biochem. Biophys. Res. Commun. 246:205-209(1998) [PubMed: 9600093] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Puhl H.L. III, Ikeda S.R., Aronstam R.S.
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed: 15057824] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skin and Uterus.
+Additional computationally mapped references.

Cross-references

Sequence databases

AB010414 mRNA. Translation: BAA28348.1.
AF493874 mRNA. Translation: AAM12588.1.
AC005512 Genomic DNA. Translation: AAC32595.1.
BC014466 mRNA. Translation: AAH14466.1.
BC053630 mRNA. Translation: AAH53630.1.
PIRJW0050.
RefSeqNP_443079.1.
UniGeneHs.515544

3D structure databases

HSSPHSSP built from PDB template 1GG2 based on UniProtKB P16874.
SMRO60262. Positions 4-63.
ModBaseSearch...

Protein-protein interaction databases

IntActO60262.

Proteomic databases

PeptideAtlasO60262.

Genome annotation databases

EnsemblENSG00000213611. Homo sapiens. [Contig view]
GeneID2788.
KEGGhsa:2788.

Organism-specific databases

H-InvDBHIX0020378.
HGNCHGNC:4410. GNG7.
MIM604430. gene.
PharmGKBPA28789.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOVERGENO60262.

Enzyme and pathway databases

ReactomeREACT_1505. Integration of energy metabolism.

Gene expression databases

CleanExHS_GNG7.
GermOnlineENSG00000176533. Homo sapiens.

Family and domain databases

InterProIPR015898. G-protein_gamma-like.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERPTHR13809. Gprotein-gamma. 1 hit.
PfamPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSPR00321. GPROTEING.
ProDomPD003783. G-gamma. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00224. GGL. 1 hit.
[Graphical view]
PROSITEPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

LinkHubO60262.
NextBio10987.
SOURCESearch...

Entry information

Entry nameGBG7_HUMAN
AccessionPrimary (citable) accession number: O60262
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: November 25, 2008
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents