Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7

Gene

GNG7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000129962-MONOMER.
ReactomeiR-HSA-1296041. Activation of G protein gated Potassium channels.
R-HSA-163359. Glucagon signaling in metabolic regulation.
R-HSA-202040. G-protein activation.
R-HSA-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-HSA-392170. ADP signalling through P2Y purinoceptor 12.
R-HSA-392451. G beta:gamma signalling through PI3Kgamma.
R-HSA-392851. Prostacyclin signalling through prostacyclin receptor.
R-HSA-400042. Adrenaline,noradrenaline inhibits insulin secretion.
R-HSA-4086398. Ca2+ pathway.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-416482. G alpha (12/13) signalling events.
R-HSA-418217. G beta:gamma signalling through PLC beta.
R-HSA-418555. G alpha (s) signalling events.
R-HSA-418592. ADP signalling through P2Y purinoceptor 1.
R-HSA-418594. G alpha (i) signalling events.
R-HSA-418597. G alpha (z) signalling events.
R-HSA-420092. Glucagon-type ligand receptors.
R-HSA-428930. Thromboxane signalling through TP receptor.
R-HSA-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-HSA-456926. Thrombin signalling through proteinase activated receptors (PARs).
R-HSA-500657. Presynaptic function of Kainate receptors.
R-HSA-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.
R-HSA-997272. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
SignaLinkiO60262.
SIGNORiO60262.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
Gene namesi
Name:GNG7
Synonyms:GNGT7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:4410. GNG7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2788.
OpenTargetsiENSG00000176533.
PharmGKBiPA28789.

Polymorphism and mutation databases

BioMutaiGNG7.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000126352 – 65Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7Add BLAST64
PropeptideiPRO_000001263666 – 68Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei65Cysteine methyl esterBy similarity1
Lipidationi65S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiO60262.
PaxDbiO60262.
PeptideAtlasiO60262.
PRIDEiO60262.

PTM databases

iPTMnetiO60262.
PhosphoSitePlusiO60262.

Expressioni

Tissue specificityi

Expressed in a variety of tissues. Down-regulated in pancreatic and esophageal cancer.1 Publication

Gene expression databases

BgeeiENSG00000176533.
CleanExiHS_GNG7.
ExpressionAtlasiO60262. baseline and differential.
GenevisibleiO60262. HS.

Organism-specific databases

HPAiHPA057790.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

Protein-protein interaction databases

BioGridi109050. 13 interactors.
IntActiO60262. 3 interactors.
MINTiMINT-1422081.
STRINGi9606.ENSP00000371594.

Structurei

3D structure databases

ProteinModelPortaliO60262.
SMRiO60262.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiKOG4119. Eukaryota.
ENOG41122JF. LUCA.
GeneTreeiENSGT00760000119218.
HOGENOMiHOG000231034.
HOVERGENiHBG014983.
InParanoidiO60262.
KOiK04543.
OMAiSELMNYC.
OrthoDBiEOG091G17J0.
PhylomeDBiO60262.
TreeFamiTF319909.

Family and domain databases

CDDicd00068. GGL. 1 hit.
Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O60262-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSATNNIAQA RKLVEQLRIE AGIERIKVSK AASDLMSYCE QHARNDPLLV
60
GVPASENPFK DKKPCIIL
Length:68
Mass (Da):7,522
Last modified:August 1, 1998 - v1
Checksum:i704133C7BEC7FD72
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010414 mRNA. Translation: BAA28348.1.
AF493874 mRNA. Translation: AAM12588.1.
AK311750 mRNA. Translation: BAG34693.1.
AC005512 Genomic DNA. Translation: AAC32595.1.
BC014466 mRNA. Translation: AAH14466.1.
BC053630 mRNA. Translation: AAH53630.1.
CCDSiCCDS12091.1.
PIRiJW0050.
RefSeqiNP_443079.1. NM_052847.2.
XP_016882095.1. XM_017026606.1.
UniGeneiHs.515544.
Hs.735237.

Genome annotation databases

EnsembliENST00000382159; ENSP00000371594; ENSG00000176533.
GeneIDi2788.
KEGGihsa:2788.
UCSCiuc002lwd.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010414 mRNA. Translation: BAA28348.1.
AF493874 mRNA. Translation: AAM12588.1.
AK311750 mRNA. Translation: BAG34693.1.
AC005512 Genomic DNA. Translation: AAC32595.1.
BC014466 mRNA. Translation: AAH14466.1.
BC053630 mRNA. Translation: AAH53630.1.
CCDSiCCDS12091.1.
PIRiJW0050.
RefSeqiNP_443079.1. NM_052847.2.
XP_016882095.1. XM_017026606.1.
UniGeneiHs.515544.
Hs.735237.

3D structure databases

ProteinModelPortaliO60262.
SMRiO60262.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109050. 13 interactors.
IntActiO60262. 3 interactors.
MINTiMINT-1422081.
STRINGi9606.ENSP00000371594.

PTM databases

iPTMnetiO60262.
PhosphoSitePlusiO60262.

Polymorphism and mutation databases

BioMutaiGNG7.

Proteomic databases

MaxQBiO60262.
PaxDbiO60262.
PeptideAtlasiO60262.
PRIDEiO60262.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382159; ENSP00000371594; ENSG00000176533.
GeneIDi2788.
KEGGihsa:2788.
UCSCiuc002lwd.3. human.

Organism-specific databases

CTDi2788.
DisGeNETi2788.
GeneCardsiGNG7.
HGNCiHGNC:4410. GNG7.
HPAiHPA057790.
MIMi604430. gene.
neXtProtiNX_O60262.
OpenTargetsiENSG00000176533.
PharmGKBiPA28789.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4119. Eukaryota.
ENOG41122JF. LUCA.
GeneTreeiENSGT00760000119218.
HOGENOMiHOG000231034.
HOVERGENiHBG014983.
InParanoidiO60262.
KOiK04543.
OMAiSELMNYC.
OrthoDBiEOG091G17J0.
PhylomeDBiO60262.
TreeFamiTF319909.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000129962-MONOMER.
ReactomeiR-HSA-1296041. Activation of G protein gated Potassium channels.
R-HSA-163359. Glucagon signaling in metabolic regulation.
R-HSA-202040. G-protein activation.
R-HSA-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-HSA-392170. ADP signalling through P2Y purinoceptor 12.
R-HSA-392451. G beta:gamma signalling through PI3Kgamma.
R-HSA-392851. Prostacyclin signalling through prostacyclin receptor.
R-HSA-400042. Adrenaline,noradrenaline inhibits insulin secretion.
R-HSA-4086398. Ca2+ pathway.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-416482. G alpha (12/13) signalling events.
R-HSA-418217. G beta:gamma signalling through PLC beta.
R-HSA-418555. G alpha (s) signalling events.
R-HSA-418592. ADP signalling through P2Y purinoceptor 1.
R-HSA-418594. G alpha (i) signalling events.
R-HSA-418597. G alpha (z) signalling events.
R-HSA-420092. Glucagon-type ligand receptors.
R-HSA-428930. Thromboxane signalling through TP receptor.
R-HSA-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-HSA-456926. Thrombin signalling through proteinase activated receptors (PARs).
R-HSA-500657. Presynaptic function of Kainate receptors.
R-HSA-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.
R-HSA-997272. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
SignaLinkiO60262.
SIGNORiO60262.

Miscellaneous databases

ChiTaRSiGNG7. human.
GeneWikiiGNG7.
GenomeRNAii2788.
PROiO60262.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000176533.
CleanExiHS_GNG7.
ExpressionAtlasiO60262. baseline and differential.
GenevisibleiO60262. HS.

Family and domain databases

CDDicd00068. GGL. 1 hit.
Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGBG7_HUMAN
AccessioniPrimary (citable) accession number: O60262
Secondary accession number(s): B2R496
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: November 2, 2016
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.