O60259 (KLK8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kallikrein-8
Short name=hK8
EC=3.4.21.118

Alternative name(s):
Neuropsin
Short name=NP
Ovasin
Serine protease 19
Serine protease TADG-14
Tumor-associated differentially expressed gene 14 protein

Gene names

Name:	KLK8
Synonyms:	NRPN, PRSS19, TADG14
ORF Names:	UNQ283/PRO322

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	260 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury. Ref.16
Catalytic activity	Cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys. Ref.16
Enzyme regulation	Inhibited by a range of serine protease inhibitors including antipain, aprotinin, leupeptin, benzamidine and soybean trypsin inhibitor. Ref.16
Subunit structure	Interacts with SPINK9. Ref.19
Subcellular location	Secreted. Cytoplasm. Note: Shows a cytoplasmic distribution in the keratinocytes. Ref.18
Tissue specificity	Isoform 1 is predominantly expressed in the pancreas. Isoform 2 is expressed in adult brain and hippocampus. Isoform 1 and isoform 2 are found in fetal brain and placenta. Detected in salivary gland, uterus, thymus, breast, testis and kidney but not in spleen, liver, lung or normal ovarian tissue. Displays an 11.5-fold increase in Alzheimer disease hippocampus compared to controls and is overexpressed in some ovarian carcinomas. Expressed at low levels in normal skin while high levels are found in psoriasis vulgaris, seborrheic keratosis, lichen planus and squamous cell carcinoma skin samples. Expressed in the keratinocytes. Ref.5 Ref.13 Ref.14 Ref.18
Miscellaneous	Expressed at high levels in serum, ascites fluid and tumor cytosol of advanced stage ovarian cancer patients and may serve as a marker of ovarian cancer.
Sequence similarities	Belongs to the peptidase S1 family. Kallikrein subfamily. Contains 1 peptidase S1 domain.
Biophysicochemical properties	Kinetic parameters: KM=0.07 mM for Pro-Phe-Arg-MCA Ref.16 KM=0.07 mM for Z-Val-Val-Arg-MCA KM=0.07 mM for Boc-Val-Pro-Arg-MCA KM=0.10 mM for Boc-Leu-Lys-Arg-MCA KM=0.10 mM for Boc-Val-Leu-Lys-MCA KM=0.07 mM for Boc-Phe-Ser-Arg-MCA Vmax=7.1 µmol/min/mg enzyme toward Pro-Phe-Arg-MCA Vmax=5.4 µmol/min/mg enzyme toward Z-Val-Val-Arg-MCA Vmax=3.9 µmol/min/mg enzyme toward Boc-Val-Pro-Arg-MCA Vmax=2.6 µmol/min/mg enzyme toward Boc-Leu-Lys-Arg-MCA Vmax=1.9 µmol/min/mg enzyme toward Boc-Val-Leu-Lys-MCA Vmax=1.6 µmol/min/mg enzyme toward Boc-Phe-Ser-Arg-MCA pH dependence: Optimum pH is 8.5. Active from pH 7-10.

Ontologies

Keywords
Cellular component	Cytoplasm Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal
Molecular function	Hydrolase Protease Serine protease
PTM	Disulfide bond Glycoprotein Zymogen
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell death Inferred from sequence or structural similarity. Source: UniProtKB keratinocyte proliferation Inferred from sequence or structural similarity. Source: UniProtKB memory Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of axon regeneration Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of myelination Inferred from sequence or structural similarity. Source: UniProtKB neuron projection morphogenesis Inferred from sequence or structural similarity. Source: UniProtKB proteolysis Inferred from electronic annotation. Source: UniProtKB-KW regulation of synapse organization Inferred from sequence or structural similarity. Source: UniProtKB response to wounding Inferred from sequence or structural similarity. Source: UniProtKB synapse organization Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from direct assay Ref.18. Source: UniProtKB extracellular space Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	serine-type endopeptidase activity Inferred from direct assay Ref.16. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O60259-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O60259-2)

The sequence of this isoform differs from the canonical sequence as follows:
     23-23: A → AACGSLDLLTKLYAENLPCVHLNPQWPSQPSHCPRGWRSNPLPPAA

Note: Produced as a result of a human-specific mutation which is not found in other primates.

Isoform 3 (identifier: O60259-3)

The sequence of this isoform differs from the canonical sequence as follows:
     24-164: Missing.

Isoform 4 (identifier: O60259-4)

The sequence of this isoform differs from the canonical sequence as follows:
     25-32: HSRAQEDK → RFWRPPGV
     33-260: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 28	28	Potential
	Propeptide	29 – 32	4	By similarity		PRO_0000027946
	Chain	33 – 260	228	Kallikrein-8		PRO_0000027947
Regions
	Domain	33 – 257	225	Peptidase S1
Sites
	Active site	73	1	Charge relay system By similarity
	Active site	120	1	Charge relay system By similarity
	Active site	212	1	Charge relay system By similarity
Amino acid modifications
	Glycosylation	110	1	N-linked (GlcNAc...) Potential
	Disulfide bond	39 ↔ 173		By similarity
	Disulfide bond	58 ↔ 74		By similarity
	Disulfide bond	145 ↔ 246		By similarity
	Disulfide bond	152 ↔ 218		By similarity
	Disulfide bond	184 ↔ 198		By similarity
	Disulfide bond	208 ↔ 233		By similarity
Natural variations
	Alternative sequence	23	1	A → AACGSLDLLTKLYAENLPCV HLNPQWPSQPSHCPRGWRSN PLPPAA in isoform 2.		VSP_005401
	Alternative sequence	24 – 164	141	Missing in isoform 3.		VSP_030350
	Alternative sequence	25 – 32	8	HSRAQEDK → RFWRPPGV in isoform 4.		VSP_030351
	Alternative sequence	33 – 260	228	Missing in isoform 4.		VSP_030352
	Natural variant	154	1	V → I. Corresponds to variant rs16988799 [ dbSNP | Ensembl ].		VAR_051855
Experimental info
	Sequence conflict	195	1	G → V in AAH40887. Ref.11

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: EF439E5B8C83E660	FASTA	260	28,048
	10 20 30 40 50 60 MGRPRPRAAK TWMFLLLLGG AWAGHSRAQE DKVLGGHECQ PHSQPWQAAL FQGQQLLCGG 70 80 90 100 110 120 VLVGGNWVLT AAHCKKPKYT VRLGDHSLQN KDGPEQEIPV VQSIPHPCYN SSDVEDHNHD 130 140 150 160 170 180 LMLLQLRDQA SLGSKVKPIS LADHCTQPGQ KCTVSGWGTV TSPRENFPDT LNCAEVKIFP 190 200 210 220 230 240 QKKCEDAYPG QITDGMVCAG SSKGADTCQG DSGGPLVCDG ALQGITSWGS DPCGRSDKPG 250 260 VYTNICRYLD WIKKIIGSKG
	Isoform 2 [UniParc]. Checksum: 2972CED7B2706AF0	FASTA	305	32,966
	10 20 30 40 50 60 MGRPRPRAAK TWMFLLLLGG AWAACGSLDL LTKLYAENLP CVHLNPQWPS QPSHCPRGWR 70 80 90 100 110 120 SNPLPPAAGH SRAQEDKVLG GHECQPHSQP WQAALFQGQQ LLCGGVLVGG NWVLTAAHCK 130 140 150 160 170 180 KPKYTVRLGD HSLQNKDGPE QEIPVVQSIP HPCYNSSDVE DHNHDLMLLQ LRDQASLGSK 190 200 210 220 230 240 VKPISLADHC TQPGQKCTVS GWGTVTSPRE NFPDTLNCAE VKIFPQKKCE DAYPGQITDG 250 260 270 280 290 300 MVCAGSSKGA DTCQGDSGGP LVCDGALQGI TSWGSDPCGR SDKPGVYTNI CRYLDWIKKI IGSKG
	Isoform 3 [UniParc]. Checksum: 2FD8164DF1641FFF	FASTA	119	12,719
	10 20 30 40 50 60 MGRPRPRAAK TWMFLLLLGG AWAENFPDTL NCAEVKIFPQ KKCEDAYPGQ ITDGMVCAGS 70 80 90 100 110 SKGADTCQGD SGGPLVCDGA LQGITSWGSD PCGRSDKPGV YTNICRYLDW IKKIIGSKG
	Isoform 4 [UniParc]. Checksum: 905DA8F5F9C8A664	FASTA	32	3,653
	10 20 30 MGRPRPRAAK TWMFLLLLGG AWAGRFWRPP GV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence analysis and expression of human neuropsin cDNA and gene." Yoshida S., Taniguchi M., Hirata A., Shiosaka S. Gene 213:9-16(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1). Tissue: Hippocampus.
[2]	"Cloning of tumor-associated differentially expressed gene-14, a novel serine protease overexpressed by ovarian carcinoma." Underwood L.J., Tanimoto H., Wang Y., Shigemasa K., Parmley T.H., O'Brien T.J. Cancer Res. 59:4435-4439(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Ovary.
[3]	"A novel form of human neuropsin, a brain-related serine protease, is generated by alternative splicing and is expressed preferentially in human adult brain." Mitsui S., Tsuruoka N., Yamashiro K., Nakazato H., Yamaguchi N. Eur. J. Biochem. 260:627-634(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2). Tissue: Brain.
[4]	"Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region." Gan L., Lee I., Smith R., Argonza-Barrett R., Lei H., McCuaig J., Moss P., Paeper B., Wang K. Gene 257:119-130(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]	"The human KLK8 (neuropsin/ovasin) gene: identification of two novel splice variants and its prognostic value in ovarian cancer." Magklara A., Scorilas A., Katsaros D., Massobrio M., Yousef G.M., Fracchioli S., Danese S., Diamandis E.P. Clin. Cancer Res. 7:806-811(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 3 AND 4), TISSUE SPECIFICITY.
[6]	"Molecular cloning and characterization of a novel serine protease, ovasin, a potential molecular marker for ovarian carcinomas." Gan L., Gelinas R., Gown A.M., Moss P., Smith R., Wang K. Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
[7]	"Human kallikrein 8 and human kallikrein 9 are organized as a bicistronic operon." Michael I.P., Diamandis E.P. Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
[8]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[9]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[10]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[11]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[12]	"Recent origin of a hominoid-specific splice form of neuropsin, a gene involved in learning and memory." Li Y., Qian Y.-P., Yu X.-J., Wang Y.-Q., Dong D.-G., Sun W., Ma R.-M., Su B. Mol. Biol. Evol. 21:2111-2115(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 2).
[13]	"Expression of the kallikrein gene family in normal and Alzheimer's disease brain." Shimizu-Okabe C., Yousef G.M., Diamandis E.P., Yoshida S., Shiosaka S., Fahnestock M. NeuroReport 12:2747-2751(2001) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[14]	"Epidermal expression of serine protease, neuropsin (KLK8) in normal and pathological skin samples." Kuwae K., Matsumoto-Miyai K., Yoshida S., Sadayama T., Yoshikawa K., Hosokawa K., Shiosaka S. Mol. Pathol. 55:235-241(2002) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[15]	"Human kallikrein 8, a novel biomarker for ovarian carcinoma." Kishi T., Grass L., Soosaipillai A., Scorilas A., Harbeck N., Schmalfeldt B., Dorn J., Mysliwiec M., Schmitt M., Diamandis E.P. Cancer Res. 63:2771-2774(2003) [PubMed] [Europe PMC] [Abstract] Cited for: USE AS A MARKER FOR OVARIAN CANCER.
[16]	"Biochemical characterization of human kallikrein 8 and its possible involvement in the degradation of extracellular matrix proteins." Rajapakse S., Ogiwara K., Takano N., Moriyama A., Takahashi T. FEBS Lett. 579:6879-6884(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, CATALYTIC ACTIVITY, ENZYME REGULATION, BIOPHYSICOCHEMICAL PROPERTIES.
[17]	"A human-specific mutation leads to the origin of a novel splice form of neuropsin (KLK8), a gene involved in learning and memory." Lu Z.-X., Peng J., Su B. Hum. Mutat. 28:978-984(2007) [PubMed] [Europe PMC] [Abstract] Cited for: ALTERNATIVE SPLICING (ISOFORM 2).
[18]	"SerpinB6 is an inhibitor of kallikrein-8 in keratinocytes." Scott F.L., Sun J., Whisstock J.C., Kato K., Bird P.I. J. Biochem. 142:435-442(2007) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[19]	"SPINK9: a selective, skin-specific Kazal-type serine protease inhibitor." Brattsand M., Stefansson K., Hubiche T., Nilsson S.K., Egelrud T. J. Invest. Dermatol. 129:1656-1665(2009) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH SPINK9.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB009849 mRNA. Translation: BAA28673.1. AB012761 Genomic DNA. Translation: BAA28676.1. AF055982 mRNA. Translation: AAD56050.1. AB008390 mRNA. Translation: BAA82665.1. AB008927 mRNA. Translation: BAA82666.1. AB010780 Genomic DNA. Translation: BAA88684.1. AF243527 Genomic DNA. Translation: AAG33361.1. AF251125 Genomic DNA. Translation: AAF79144.1. AF251125 Genomic DNA. Translation: AAF79145.1. AF095742 mRNA. Translation: AAD25979.1. AF095743 Genomic DNA. Translation: AAD29574.1. DQ267420 mRNA. Translation: ABB83339.1. AY359036 mRNA. Translation: AAQ89395.1. AC011473 Genomic DNA. Translation: AAG23254.1. AC011483 Genomic DNA. No translation available. CH471135 Genomic DNA. Translation: EAW71962.1. BC040887 mRNA. Translation: AAH40887.1. AY563055 Genomic DNA. Translation: AAT76913.1. AY563055 Genomic DNA. Translation: AAT76914.1. AY563056 Genomic DNA. Translation: AAT76915.1. AY563056 Genomic DNA. Translation: AAT76916.1. AY563057 Genomic DNA. Translation: AAT76917.1. AY563057 Genomic DNA. Translation: AAT76918.1. AY563058 Genomic DNA. Translation: AAT76919.1. AY563058 Genomic DNA. Translation: AAT76920.1. AY563059 Genomic DNA. Translation: AAT76921.1. AY563059 Genomic DNA. Translation: AAT76922.1. AY563060 Genomic DNA. Translation: AAT76923.1. AY563060 Genomic DNA. Translation: AAT76924.1. AY563061 Genomic DNA. Translation: AAT76925.1. AY563061 Genomic DNA. Translation: AAT76926.1. AY563062 Genomic DNA. Translation: AAT76927.1. AY563062 Genomic DNA. Translation: AAT76928.1. AY563063 Genomic DNA. Translation: AAT76929.1. AY563063 Genomic DNA. Translation: AAT76930.1. AY563064 Genomic DNA. Translation: AAT76931.1. AY563064 Genomic DNA. Translation: AAT76932.1. AY563065 Genomic DNA. Translation: AAT76933.1. AY563065 Genomic DNA. Translation: AAT76934.1. AY563066 Genomic DNA. Translation: AAT76935.1. AY563066 Genomic DNA. Translation: AAT76936.1. AY563067 Genomic DNA. Translation: AAT76937.1. AY563067 Genomic DNA. Translation: AAT76938.1.
IPI	IPI00016000. IPI00016041. IPI00028484. IPI00219892.
RefSeq	NP_009127.1. NM_007196.2. NP_653088.1. NM_144505.1. NP_653089.1. NM_144506.1. NP_653090.1. NM_144507.1.
UniGene	Hs.104570.
3D structure databases
ProteinModelPortal	O60259.
ModBase	Search...
Protein-protein interaction databases
IntAct	O60259. 1 interaction.
Protein family/group databases
MEROPS	S01.244.
PTM databases
PhosphoSite	O60259.
Proteomic databases
PaxDb	O60259.
PRIDE	O60259.
Protocols and materials databases
DNASU	11202.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000291726; ENSP00000291726; ENSG00000129455. ENST00000320838; ENSP00000325072; ENSG00000129455. ENST00000347619; ENSP00000341555; ENSG00000129455. ENST00000391806; ENSP00000375682; ENSG00000129455. ENST00000593490; ENSP00000469278; ENSG00000129455. ENST00000600767; ENSP00000472016; ENSG00000129455.
GeneID	11202.
KEGG	hsa:11202.
UCSC	uc002puq.1. human. uc002pur.1. human. uc002pus.1. human. uc002put.1. human.
Organism-specific databases
CTD	11202.
GeneCards	GC19M051499.
HGNC	HGNC:6369. KLK8.
HPA	CAB019393.
MIM	605644. gene.
neXtProt	NX_O60259.
PharmGKB	PA30158.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5640.
HOVERGEN	HBG013304.
KO	K08650.
OMA	TKLYAEN.
PhylomeDB	O60259.
Enzyme and pathway databases
BRENDA	3.4.21.118. 2681.
Gene expression databases
ArrayExpress	O60259.
Bgee	O60259.
Genevestigator	O60259.
GermOnline	ENSG00000129455. Homo sapiens.
Family and domain databases
InterPro	IPR001254. Peptidase_S1. IPR018114. Peptidase_S1_AS. IPR001314. Peptidase_S1A. IPR009003. Trypsin-like_Pept_dom. [Graphical view]
Pfam	PF00089. Trypsin. 1 hit. [Graphical view]
PRINTS	PR00722. CHYMOTRYPSIN.
SMART	SM00020. Tryp_SPc. 1 hit. [Graphical view]
SUPFAM	SSF50494. Pept_Ser_Cys. 1 hit.
PROSITE	PS50240. TRYPSIN_DOM. 1 hit. PS00134. TRYPSIN_HIS. 1 hit. PS00135. TRYPSIN_SER. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	O60259.
ChEMBL	CHEMBL4812.
GenomeRNAi	11202.
NextBio	42641.
SOURCE	Search...

Entry information

Entry name

KLK8_HUMAN

Accession

Primary (citable) accession number: O60259
Secondary accession number(s): Q5V9X1 , Q5V9X2, Q8IW69, Q9HCB3, Q9NR68, Q9NR69, Q9UIL9, Q9UQ47

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	August 1, 1998
Last modified:	May 1, 2013
This is version 123 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.