ID   FGF17_HUMAN             Reviewed;         216 AA.
AC   O60258; B7ZLG4; Q2M2W1;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   25-JAN-2012, entry version 104.
DE   RecName: Full=Fibroblast growth factor 17;
DE            Short=FGF-17;
DE   Flags: Precursor;
GN   Name=FGF17; ORFNames=UNQ161/PRO187;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   TISSUE=Fetal brain;
RX   MEDLINE=98183421; PubMed=9514906; DOI=10.1006/bbrc.1998.8239;
RA   Hoshikawa M., Ohbayashi N., Yonamine A., Konishi M., Ozaki K.,
RA   Fukui S., Itoh N.;
RT   "Structure and expression of a novel fibroblast growth factor, FGF-17,
RT   preferentially expressed in the embryonic brain.";
RL   Biochem. Biophys. Res. Commun. 244:187-191(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX   MEDLINE=22887296; PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA   Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA   Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA   Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA   Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA   Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA   Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale
RT   effort to identify novel human secreted and transmembrane proteins: a
RT   bioinformatics assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RG   NIEHS SNPs program;
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   INTERACTION WITH FGFR3 AND FGFR4, AND FUNCTION IN STIMULATION OF CELL
RP   PROLIFERATION.
RX   PubMed=16597617; DOI=10.1074/jbc.M601252200;
RA   Zhang X., Ibrahimi O.A., Olsen S.K., Umemori H., Mohammadi M.,
RA   Ornitz D.M.;
RT   "Receptor specificity of the fibroblast growth factor family. The
RT   complete mammalian FGF family.";
RL   J. Biol. Chem. 281:15694-15700(2006).
RN   [7]
RP   REVIEW.
RX   PubMed=20094046; DOI=10.1038/nrc2780;
RA   Turner N., Grose R.;
RT   "Fibroblast growth factor signalling: from development to cancer.";
RL   Nat. Rev. Cancer 10:116-129(2010).
CC   -!- FUNCTION: Plays an important role in the regulation of embryonic
CC       development and as signaling molecule in the induction and
CC       patterning of the embryonic brain. Required for normal brain
CC       development.
CC   -!- SUBUNIT: Interacts with FGFR3 and FGFR4.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=O60258-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=O60258-2; Sequence=VSP_008715;
CC         Note=No experimental confirmation available;
CC   -!- TISSUE SPECIFICITY: Preferentially expressed in the embryonic
CC       brain.
CC   -!- DEVELOPMENTAL STAGE: Detected in embryos at E14.5, but not at
CC       E10.5 and E19.5. Preferentially expressed in the neuroepithelia of
CC       the isthmus and septum of the embryonic brain at E14.5.
CC   -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC   -!- WEB RESOURCE: Name=NIEHS-SNPs;
CC       URL="http://egp.gs.washington.edu/data/fgf17/";
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DR   EMBL; AB009249; BAA25429.1; -; mRNA.
DR   EMBL; AY358869; AAQ89228.1; -; mRNA.
DR   EMBL; AF497475; AAM09570.1; -; Genomic_DNA.
DR   EMBL; CH471080; EAW63729.1; -; Genomic_DNA.
DR   EMBL; BC069475; AAH69475.1; -; mRNA.
DR   EMBL; BC105131; AAI05132.1; -; mRNA.
DR   EMBL; BC113489; AAI13490.1; -; mRNA.
DR   EMBL; BC143789; AAI43790.1; -; mRNA.
DR   IPI; IPI00028483; -.
DR   IPI; IPI00385645; -.
DR   RefSeq; NP_003858.1; NM_003867.2.
DR   UniGene; Hs.248192; -.
DR   ProteinModelPortal; O60258; -.
DR   SMR; O60258; 33-178.
DR   STRING; O60258; -.
DR   PRIDE; O60258; -.
DR   Ensembl; ENST00000359441; ENSP00000352414; ENSG00000158815.
DR   GeneID; 8822; -.
DR   KEGG; hsa:8822; -.
DR   UCSC; uc003xag.1; human.
DR   UCSC; uc003xah.1; human.
DR   CTD; 8822; -.
DR   GeneCards; GC08P021899; -.
DR   H-InvDB; HIX0201292; -.
DR   HGNC; HGNC:3673; FGF17.
DR   MIM; 603725; gene.
DR   neXtProt; NX_O60258; -.
DR   PharmGKB; PA28112; -.
DR   eggNOG; prNOG14177; -.
DR   GeneTree; ENSGT00570000079132; -.
DR   HOGENOM; HBG714373; -.
DR   HOVERGEN; HBG005659; -.
DR   InParanoid; O60258; -.
DR   OMA; LCCQTQV; -.
DR   OrthoDB; EOG441QCG; -.
DR   PhylomeDB; O60258; -.
DR   Pathway_Interaction_DB; fgf_pathway; FGF signaling pathway.
DR   Reactome; REACT_111102; Signal Transduction.
DR   NextBio; 33096; -.
DR   ArrayExpress; O60258; -.
DR   Bgee; O60258; -.
DR   CleanEx; HS_FGF17; -.
DR   Genevestigator; O60258; -.
DR   GermOnline; ENSG00000158815; Homo sapiens.
DR   GO; GO:0005615; C:extracellular space; TAS:ProtInc.
DR   GO; GO:0008083; F:growth factor activity; TAS:ProtInc.
DR   GO; GO:0004713; F:protein tyrosine kinase activity; TAS:Reactome.
DR   GO; GO:0005105; F:type 1 fibroblast growth factor receptor binding; IDA:UniProtKB.
DR   GO; GO:0005111; F:type 2 fibroblast growth factor receptor binding; IDA:UniProtKB.
DR   GO; GO:0007267; P:cell-cell signaling; TAS:ProtInc.
DR   GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.
DR   GO; GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome.
DR   GO; GO:0007399; P:nervous system development; TAS:ProtInc.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR002348; IL1_HBGF.
DR   KO; K04358; -.
DR   PANTHER; PTHR11486; IL1_HBGF; 1.
DR   Pfam; PF00167; FGF; 1.
DR   PRINTS; PR00262; IL1HBGF.
DR   SMART; SM00442; FGF; 1.
DR   SUPFAM; SSF50353; Cytok_IL1_like; 1.
DR   PROSITE; PS00247; HBGF_FGF; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Complete proteome; Developmental protein;
KW   Glycoprotein; Growth factor; Reference proteome; Secreted; Signal.
FT   SIGNAL        1     22       Potential.
FT   CHAIN        23    216       Fibroblast growth factor 17.
FT                                /FTId=PRO_0000008985.
FT   CARBOHYD    137    137       N-linked (GlcNAc...) (Potential).
FT   VAR_SEQ      25     35       Missing (in isoform 2).
FT                                /FTId=VSP_008715.
SQ   SEQUENCE   216 AA;  24891 MW;  2EE0288675220F4C CRC64;
     MGAARLLPNL TLCLQLLILC CQTQGENHPS PNFNQYVRDQ GAMTDQLSRR QIREYQLYSR
     TSGKHVQVTG RRISATAEDG NKFAKLIVET DTFGSRVRIK GAESEKYICM NKRGKLIGKP
     SGKSKDCVFT EIVLENNYTA FQNARHEGWF MAFTRQGRPR QASRSRQNQR EAHFIKRLYQ
     GQLPFPNHAE KQKQFEFVGS APTRRTKRTR RPQPLT
//