O60258 (FGF17_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 117.
History...
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Fibroblast growth factor 17 Short name=FGF-17 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) [Reference proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo![]() |
Protein attributes
| Sequence length | 216 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development. Ref.6 |
| Subunit structure | Interacts with FGFR3 and FGFR4. Ref.6 |
| Subcellular location | |
| Tissue specificity | Preferentially expressed in the embryonic brain. |
| Developmental stage | Detected in embryos at E14.5, but not at E10.5 and E19.5. Preferentially expressed in the neuroepithelia of the isthmus and septum of the embryonic brain at E14.5. |
| Sequence similarities | Belongs to the heparin-binding growth factors family. |
Ontologies
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: O60258-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: O60258-2) The sequence of this isoform differs from the canonical sequence as follows: 25-35: Missing. | ||||||
| Note: No experimental confirmation available. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 22 | 22 | Potential | ||||||
| Chain | 23 – 216 | 194 | Fibroblast growth factor 17 | PRO_0000008985 | |||||
Amino acid modifications | |||||||||
| Glycosylation | 137 | 1 | N-linked (GlcNAc...) Potential | ||||||
Natural variations | |||||||||
| Alternative sequence | 25 – 35 | 11 | Missing in isoform 2. | VSP_008715 | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Structure and expression of a novel fibroblast growth factor, FGF-17, preferentially expressed in the embryonic brain." Hoshikawa M., Ohbayashi N., Yonamine A., Konishi M., Ozaki K., Fukui S., Itoh N. Biochem. Biophys. Res. Commun. 244:187-191(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Fetal brain. |
| [2] | "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. Gray A.M.Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). |
| [3] | NIEHS SNPs program Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [4] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). |
| [6] | "Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family." Zhang X., Ibrahimi O.A., Olsen S.K., Umemori H., Mohammadi M., Ornitz D.M. J. Biol. Chem. 281:15694-15700(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH FGFR3 AND FGFR4, FUNCTION IN STIMULATION OF CELL PROLIFERATION. |
| [7] | "Fibroblast growth factor signalling: from development to cancer." Turner N., Grose R. Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW. |
| + | Additional computationally mapped references. |
Web resources
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AB009249 mRNA. Translation: BAA25429.1. AY358869 mRNA. Translation: AAQ89228.1. AF497475 Genomic DNA. Translation: AAM09570.1. CH471080 Genomic DNA. Translation: EAW63729.1. BC069475 mRNA. Translation: AAH69475.1. BC105131 mRNA. Translation: AAI05132.1. BC113489 mRNA. Translation: AAI13490.1. BC143789 mRNA. Translation: AAI43790.1. |
| IPI | IPI00028483. IPI00385645. |
| RefSeq | NP_003858.1. NM_003867.2. |
| UniGene | Hs.248192. |
3D structure databases | |
| ProteinModelPortal | O60258. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 9606.ENSP00000352414. |
PTM databases | |
| PhosphoSite | O60258. |
Proteomic databases | |
| PaxDb | O60258. |
| PRIDE | O60258. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000359441; ENSP00000352414; ENSG00000158815. ENST00000518533; ENSP00000431041; ENSG00000158815. |
| GeneID | 8822. |
| KEGG | hsa:8822. |
| UCSC | uc003xag.3. human. uc003xah.3. human. |
Organism-specific databases | |
| CTD | 8822. |
| GeneCards | GC08P021899. |
| HGNC | HGNC:3673. FGF17. |
| HPA | HPA052600. |
| MIM | 603725. gene. |
| neXtProt | NX_O60258. |
| PharmGKB | PA28112. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | NOG327940. |
| HOGENOM | HOG000115986. |
| HOVERGEN | HBG005659. |
| InParanoid | O60258. |
| KO | K04358. |
| OMA | CQTQVTA. |
| OrthoDB | EOG441QCG. |
| PhylomeDB | O60258. |
Enzyme and pathway databases | |
| Pathway_Interaction_DB | fgf_pathway. FGF signaling pathway. |
| Reactome | REACT_111102. Signal Transduction. REACT_116125. Disease. REACT_6900. Immune System. |
Gene expression databases | |
| Bgee | O60258. |
| CleanEx | HS_FGF17. |
| Genevestigator | O60258. |
| GermOnline | ENSG00000158815. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR008996. Cytokine_IL1-like. IPR002348. IL1_HBGF. [Graphical view] |
| PANTHER | PTHR11486. PTHR11486. 1 hit. |
| Pfam | PF00167. FGF. 1 hit. [Graphical view] |
| PRINTS | PR00262. IL1HBGF. |
| SMART | SM00442. FGF. 1 hit. [Graphical view] |
| SUPFAM | SSF50353. Cytok_IL1_like. 1 hit. |
| PROSITE | PS00247. HBGF_FGF. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| GenomeRNAi | 8822. |
| NextBio | 33096. |
| SOURCE | Search... |
Entry information
| Entry name | FGF17_HUMAN | ||||||||
| Accession | Primary (citable) accession number: O60258 Secondary accession number(s): B7ZLG4, Q2M2W1 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 8 Human chromosome 8: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with
