O60258 (FGF17_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fibroblast growth factor 17
Short name=FGF-17

Gene names

Name:	FGF17
ORF Names:	UNQ161/PRO187

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	216 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development. Ref.6
Subunit structure	Interacts with FGFR3 and FGFR4. Ref.6
Subcellular location	Secreted.
Tissue specificity	Preferentially expressed in the embryonic brain.
Developmental stage	Detected in embryos at E14.5, but not at E10.5 and E19.5. Preferentially expressed in the neuroepithelia of the isthmus and septum of the embryonic brain at E14.5.
Sequence similarities	Belongs to the heparin-binding growth factors family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing
Domain	Signal
Molecular function	Developmental protein Growth factor
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell-cell signaling Traceable author statement Ref.1. Source: ProtInc fibroblast growth factor receptor signaling pathway Traceable author statement. Source: Reactome insulin receptor signaling pathway Traceable author statement. Source: Reactome nervous system development Traceable author statement Ref.1. Source: ProtInc positive regulation of cell proliferation Inferred from electronic annotation. Source: Compara
Cellular_component	extracellular space Traceable author statement Ref.1. Source: ProtInc
Molecular_function	growth factor activity Traceable author statement Ref.1. Source: ProtInc type 1 fibroblast growth factor receptor binding Inferred from direct assay PubMed 16384934. Source: UniProtKB type 2 fibroblast growth factor receptor binding Inferred from direct assay PubMed 16384934. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O60258-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O60258-2)

The sequence of this isoform differs from the canonical sequence as follows:
     25-35: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 216	194	Fibroblast growth factor 17		PRO_0000008985
Amino acid modifications
	Glycosylation	137	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	25 – 35	11	Missing in isoform 2.		VSP_008715

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 2EE0288675220F4C	FASTA	216	24,891
	10 20 30 40 50 60 MGAARLLPNL TLCLQLLILC CQTQGENHPS PNFNQYVRDQ GAMTDQLSRR QIREYQLYSR 70 80 90 100 110 120 TSGKHVQVTG RRISATAEDG NKFAKLIVET DTFGSRVRIK GAESEKYICM NKRGKLIGKP 130 140 150 160 170 180 SGKSKDCVFT EIVLENNYTA FQNARHEGWF MAFTRQGRPR QASRSRQNQR EAHFIKRLYQ 190 200 210 GQLPFPNHAE KQKQFEFVGS APTRRTKRTR RPQPLT
	Isoform 2 [UniParc]. Checksum: 7DCA34B12D3602A7	FASTA	205	23,669
	10 20 30 40 50 60 MGAARLLPNL TLCLQLLILC CQTQYVRDQG AMTDQLSRRQ IREYQLYSRT SGKHVQVTGR 70 80 90 100 110 120 RISATAEDGN KFAKLIVETD TFGSRVRIKG AESEKYICMN KRGKLIGKPS GKSKDCVFTE 130 140 150 160 170 180 IVLENNYTAF QNARHEGWFM AFTRQGRPRQ ASRSRQNQRE AHFIKRLYQG QLPFPNHAEK 190 200 QKQFEFVGSA PTRRTKRTRR PQPLT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structure and expression of a novel fibroblast growth factor, FGF-17, preferentially expressed in the embryonic brain." Hoshikawa M., Ohbayashi N., Yonamine A., Konishi M., Ozaki K., Fukui S., Itoh N. Biochem. Biophys. Res. Commun. 244:187-191(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Fetal brain.
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[3]	NIEHS SNPs program Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
[6]	"Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family." Zhang X., Ibrahimi O.A., Olsen S.K., Umemori H., Mohammadi M., Ornitz D.M. J. Biol. Chem. 281:15694-15700(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH FGFR3 AND FGFR4, FUNCTION IN STIMULATION OF CELL PROLIFERATION.
[7]	"Fibroblast growth factor signalling: from development to cancer." Turner N., Grose R. Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
+	Additional computationally mapped references.

Web resources

NIEHS-SNPs

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB009249 mRNA. Translation: BAA25429.1. AY358869 mRNA. Translation: AAQ89228.1. AF497475 Genomic DNA. Translation: AAM09570.1. CH471080 Genomic DNA. Translation: EAW63729.1. BC069475 mRNA. Translation: AAH69475.1. BC105131 mRNA. Translation: AAI05132.1. BC113489 mRNA. Translation: AAI13490.1. BC143789 mRNA. Translation: AAI43790.1.
IPI	IPI00028483. IPI00385645.
RefSeq	NP_003858.1. NM_003867.2.
UniGene	Hs.248192.
3D structure databases
ProteinModelPortal	O60258.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000352414.
PTM databases
PhosphoSite	O60258.
Proteomic databases
PaxDb	O60258.
PRIDE	O60258.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000359441; ENSP00000352414; ENSG00000158815. ENST00000518533; ENSP00000431041; ENSG00000158815.
GeneID	8822.
KEGG	hsa:8822.
UCSC	uc003xag.3. human. uc003xah.3. human.
Organism-specific databases
CTD	8822.
GeneCards	GC08P021899.
HGNC	HGNC:3673. FGF17.
HPA	HPA052600.
MIM	603725. gene.
neXtProt	NX_O60258.
PharmGKB	PA28112.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG327940.
HOGENOM	HOG000115986.
HOVERGEN	HBG005659.
InParanoid	O60258.
KO	K04358.
OMA	CQTQVTA.
OrthoDB	EOG441QCG.
PhylomeDB	O60258.
Enzyme and pathway databases
Pathway_Interaction_DB	fgf_pathway. FGF signaling pathway.
Reactome	REACT_111102. Signal Transduction. REACT_116125. Disease. REACT_6900. Immune System.
Gene expression databases
Bgee	O60258.
CleanEx	HS_FGF17.
Genevestigator	O60258.
GermOnline	ENSG00000158815. Homo sapiens.
Family and domain databases
InterPro	IPR008996. Cytokine_IL1-like. IPR002348. IL1_HBGF. [Graphical view]
PANTHER	PTHR11486. PTHR11486. 1 hit.
Pfam	PF00167. FGF. 1 hit. [Graphical view]
PRINTS	PR00262. IL1HBGF.
SMART	SM00442. FGF. 1 hit. [Graphical view]
SUPFAM	SSF50353. Cytok_IL1_like. 1 hit.
PROSITE	PS00247. HBGF_FGF. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	8822.
NextBio	33096.
SOURCE	Search...

Entry information

Entry name

FGF17_HUMAN

Accession

Primary (citable) accession number: O60258
Secondary accession number(s): B7ZLG4, Q2M2W1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	August 1, 1998
Last modified:	May 1, 2013
This is version 117 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.