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Protein

Phosphoribosyl pyrophosphate synthase-associated protein 2

Gene

PRPSAP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis.

GO - Molecular functioni

  • enzyme inhibitor activity Source: ProtInc
  • magnesium ion binding Source: InterPro
  • ribose phosphate diphosphokinase activity Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Nucleotide biosynthesis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000141127-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosyl pyrophosphate synthase-associated protein 2
Short name:
PRPP synthase-associated protein 2
Alternative name(s):
41 kDa phosphoribosypyrophosphate synthetase-associated protein
Short name:
PAP41
Gene namesi
Name:PRPSAP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:9467. PRPSAP2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi5636.
OpenTargetsiENSG00000141127.
PharmGKBiPA33822.

Chemistry databases

ChEMBLiCHEMBL2646.

Polymorphism and mutation databases

BioMutaiPRPSAP2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001410821 – 369Phosphoribosyl pyrophosphate synthase-associated protein 2Add BLAST369

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei5PhosphothreonineCombined sources1
Modified residuei219PhosphoserineCombined sources1
Modified residuei227PhosphoserineCombined sources1 Publication1
Modified residuei233PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO60256.
MaxQBiO60256.
PaxDbiO60256.
PeptideAtlasiO60256.
PRIDEiO60256.

PTM databases

iPTMnetiO60256.
PhosphoSitePlusiO60256.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000141127.
CleanExiHS_PRPSAP2.
ExpressionAtlasiO60256. baseline and differential.
GenevisibleiO60256. HS.

Organism-specific databases

HPAiHPA021881.

Interactioni

Subunit structurei

Binds to PRPS1 and PRPS2.

Binary interactionsi

WithEntry#Exp.IntActNotes
PRPS1P608915EBI-724960,EBI-749195
PRPSAP1Q145584EBI-724960,EBI-724449

Protein-protein interaction databases

BioGridi111619. 28 interactors.
IntActiO60256. 10 interactors.
MINTiMINT-5003869.
STRINGi9606.ENSP00000268835.

Chemistry databases

BindingDBiO60256.

Structurei

Secondary structure

1369
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi21 – 24Combined sources4
Helixi29 – 32Combined sources4
Helixi33 – 42Combined sources10
Beta strandi49 – 53Combined sources5
Beta strandi59 – 63Combined sources5
Beta strandi71 – 75Combined sources5
Helixi82 – 98Combined sources17
Beta strandi102 – 107Combined sources6
Helixi126 – 136Combined sources11
Beta strandi141 – 146Combined sources6
Helixi150 – 155Combined sources6
Beta strandi156 – 158Combined sources3
Beta strandi160 – 163Combined sources4
Helixi166 – 176Combined sources11
Helixi180 – 182Combined sources3
Beta strandi183 – 189Combined sources7
Helixi190 – 192Combined sources3
Helixi193 – 202Combined sources10
Beta strandi206 – 210Combined sources5
Beta strandi256 – 258Combined sources3
Beta strandi263 – 272Combined sources10
Helixi276 – 287Combined sources12
Beta strandi292 – 300Combined sources9
Helixi306 – 312Combined sources7
Beta strandi317 – 324Combined sources8
Helixi327 – 331Combined sources5
Beta strandi336 – 339Combined sources4
Helixi342 – 354Combined sources13
Beta strandi362 – 364Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JI4X-ray2.55A13-369[»]
ProteinModelPortaliO60256.
SMRiO60256.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO60256.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1503. Eukaryota.
COG0462. LUCA.
GeneTreeiENSGT00550000074583.
HOGENOMiHOG000210451.
HOVERGENiHBG001520.
InParanoidiO60256.
OMAiMVYACRT.
OrthoDBiEOG091G0ZG8.
PhylomeDBiO60256.
TreeFamiTF106367.

Family and domain databases

CDDicd06223. PRTases_typeI. 1 hit.
Gene3Di3.40.50.2020. 3 hits.
InterProiIPR029099. Pribosyltran_N.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR005946. Rib-P_diPkinase.
[Graphical view]
PfamiPF14572. Pribosyl_synth. 1 hit.
PF13793. Pribosyltran_N. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 2 hits.
TIGRFAMsiTIGR01251. ribP_PPkin. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O60256-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFCVTPPELE TKMNITKGGL VLFSANSNSS CMELSKKIAE RLGVEMGKVQ
60 70 80 90 100
VYQEPNRETR VQIQESVRGK DVFIIQTVSK DVNTTIMELL IMVYACKTSC
110 120 130 140 150
AKSIIGVIPY FPYSKQCKMR KRGSIVSKLL ASMMCKAGLT HLITMDLHQK
160 170 180 190 200
EIQGFFNIPV DNLRASPFLL QYIQEEIPDY RNAVIVAKSP ASAKRAQSFA
210 220 230 240 250
ERLRLGIAVI HGEAQDAESD LVDGRHSPPM VRSVAAIHPS LEIPMLIPKE
260 270 280 290 300
KPPITVVGDV GGRIAIIVDD IIDDVDSFLA AAETLKERGA YKIFVMATHG
310 320 330 340 350
LLSSDAPRRI EESAIDEVVV TNTIPHEVQK LQCPKIKTVD ISMILSEAIR
360
RIHNGESMSY LFRNIGLDD
Length:369
Mass (Da):40,926
Last modified:August 1, 1998 - v1
Checksum:i12A0E46BD4AC55BF
GO
Isoform 2 (identifier: O60256-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     41-80: Missing.

Note: No experimental confirmation available.
Show »
Length:329
Mass (Da):36,297
Checksum:i8920D91D0C8535EF
GO
Isoform 3 (identifier: O60256-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     269-317: Missing.

Note: No experimental confirmation available.
Show »
Length:320
Mass (Da):35,548
Checksum:i4844D7A06BBE45FC
GO
Isoform 4 (identifier: O60256-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-86: Missing.

Note: No experimental confirmation available.
Show »
Length:283
Mass (Da):31,322
Checksum:i25A38F2CDBFC3429
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti121K → R in BAG64840 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0547651 – 86Missing in isoform 4. 1 PublicationAdd BLAST86
Alternative sequenceiVSP_04473141 – 80Missing in isoform 2. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_046462269 – 317Missing in isoform 3. 1 PublicationAdd BLAST49

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007851 mRNA. Translation: BAA25435.1.
AK303911 mRNA. Translation: BAG64840.1.
AK304544 mRNA. Translation: BAG65341.1.
CR457082 mRNA. Translation: CAG33363.1.
AC090286 Genomic DNA. No translation available.
AC107982 Genomic DNA. No translation available.
BC106050 mRNA. Translation: AAI06051.1.
BC101670 mRNA. Translation: AAI01671.1.
BC101672 mRNA. Translation: AAI01673.1.
BC143475 mRNA. Translation: AAI43476.1.
CCDSiCCDS11200.1. [O60256-1]
CCDS58525.1. [O60256-3]
CCDS58526.1. [O60256-2]
CCDS58527.1. [O60256-4]
RefSeqiNP_001230865.1. NM_001243936.1. [O60256-2]
NP_001230869.1. NM_001243940.1. [O60256-3]
NP_001230870.1. NM_001243941.1. [O60256-4]
NP_001230871.1. NM_001243942.1. [O60256-4]
NP_002758.1. NM_002767.3. [O60256-1]
XP_005256782.1. XM_005256725.2. [O60256-1]
XP_005256783.1. XM_005256726.1. [O60256-1]
XP_005256786.1. XM_005256729.4. [O60256-4]
XP_016880354.1. XM_017024865.1. [O60256-1]
XP_016880355.1. XM_017024866.1. [O60256-1]
XP_016880356.1. XM_017024867.1. [O60256-1]
XP_016880360.1. XM_017024871.1. [O60256-4]
XP_016880361.1. XM_017024872.1. [O60256-4]
XP_016880362.1. XM_017024873.1. [O60256-4]
XP_016880363.1. XM_017024874.1. [O60256-4]
XP_016880364.1. XM_017024875.1. [O60256-4]
XP_016880365.1. XM_017024876.1. [O60256-4]
UniGeneiHs.632236.

Genome annotation databases

EnsembliENST00000268835; ENSP00000268835; ENSG00000141127. [O60256-1]
ENST00000419071; ENSP00000392536; ENSG00000141127. [O60256-2]
ENST00000536323; ENSP00000443967; ENSG00000141127. [O60256-4]
ENST00000542013; ENSP00000439129; ENSG00000141127. [O60256-3]
ENST00000610773; ENSP00000481322; ENSG00000141127. [O60256-4]
GeneIDi5636.
KEGGihsa:5636.
UCSCiuc002guo.3. human. [O60256-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007851 mRNA. Translation: BAA25435.1.
AK303911 mRNA. Translation: BAG64840.1.
AK304544 mRNA. Translation: BAG65341.1.
CR457082 mRNA. Translation: CAG33363.1.
AC090286 Genomic DNA. No translation available.
AC107982 Genomic DNA. No translation available.
BC106050 mRNA. Translation: AAI06051.1.
BC101670 mRNA. Translation: AAI01671.1.
BC101672 mRNA. Translation: AAI01673.1.
BC143475 mRNA. Translation: AAI43476.1.
CCDSiCCDS11200.1. [O60256-1]
CCDS58525.1. [O60256-3]
CCDS58526.1. [O60256-2]
CCDS58527.1. [O60256-4]
RefSeqiNP_001230865.1. NM_001243936.1. [O60256-2]
NP_001230869.1. NM_001243940.1. [O60256-3]
NP_001230870.1. NM_001243941.1. [O60256-4]
NP_001230871.1. NM_001243942.1. [O60256-4]
NP_002758.1. NM_002767.3. [O60256-1]
XP_005256782.1. XM_005256725.2. [O60256-1]
XP_005256783.1. XM_005256726.1. [O60256-1]
XP_005256786.1. XM_005256729.4. [O60256-4]
XP_016880354.1. XM_017024865.1. [O60256-1]
XP_016880355.1. XM_017024866.1. [O60256-1]
XP_016880356.1. XM_017024867.1. [O60256-1]
XP_016880360.1. XM_017024871.1. [O60256-4]
XP_016880361.1. XM_017024872.1. [O60256-4]
XP_016880362.1. XM_017024873.1. [O60256-4]
XP_016880363.1. XM_017024874.1. [O60256-4]
XP_016880364.1. XM_017024875.1. [O60256-4]
XP_016880365.1. XM_017024876.1. [O60256-4]
UniGeneiHs.632236.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JI4X-ray2.55A13-369[»]
ProteinModelPortaliO60256.
SMRiO60256.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111619. 28 interactors.
IntActiO60256. 10 interactors.
MINTiMINT-5003869.
STRINGi9606.ENSP00000268835.

Chemistry databases

BindingDBiO60256.
ChEMBLiCHEMBL2646.

PTM databases

iPTMnetiO60256.
PhosphoSitePlusiO60256.

Polymorphism and mutation databases

BioMutaiPRPSAP2.

Proteomic databases

EPDiO60256.
MaxQBiO60256.
PaxDbiO60256.
PeptideAtlasiO60256.
PRIDEiO60256.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000268835; ENSP00000268835; ENSG00000141127. [O60256-1]
ENST00000419071; ENSP00000392536; ENSG00000141127. [O60256-2]
ENST00000536323; ENSP00000443967; ENSG00000141127. [O60256-4]
ENST00000542013; ENSP00000439129; ENSG00000141127. [O60256-3]
ENST00000610773; ENSP00000481322; ENSG00000141127. [O60256-4]
GeneIDi5636.
KEGGihsa:5636.
UCSCiuc002guo.3. human. [O60256-1]

Organism-specific databases

CTDi5636.
DisGeNETi5636.
GeneCardsiPRPSAP2.
HGNCiHGNC:9467. PRPSAP2.
HPAiHPA021881.
MIMi603762. gene.
neXtProtiNX_O60256.
OpenTargetsiENSG00000141127.
PharmGKBiPA33822.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1503. Eukaryota.
COG0462. LUCA.
GeneTreeiENSGT00550000074583.
HOGENOMiHOG000210451.
HOVERGENiHBG001520.
InParanoidiO60256.
OMAiMVYACRT.
OrthoDBiEOG091G0ZG8.
PhylomeDBiO60256.
TreeFamiTF106367.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000141127-MONOMER.

Miscellaneous databases

ChiTaRSiPRPSAP2. human.
EvolutionaryTraceiO60256.
GeneWikiiPRPSAP2.
GenomeRNAii5636.
PROiO60256.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000141127.
CleanExiHS_PRPSAP2.
ExpressionAtlasiO60256. baseline and differential.
GenevisibleiO60256. HS.

Family and domain databases

CDDicd06223. PRTases_typeI. 1 hit.
Gene3Di3.40.50.2020. 3 hits.
InterProiIPR029099. Pribosyltran_N.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR005946. Rib-P_diPkinase.
[Graphical view]
PfamiPF14572. Pribosyl_synth. 1 hit.
PF13793. Pribosyltran_N. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 2 hits.
TIGRFAMsiTIGR01251. ribP_PPkin. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKPRB_HUMAN
AccessioniPrimary (citable) accession number: O60256
Secondary accession number(s): B4E1M8
, B4E329, B7ZKZ1, E7EMY2, Q6IAS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: August 1, 1998
Last modified: November 30, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.