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Protein

Protein SOX-15

Gene

SOX15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the 5'-AACAAT-3' sequence.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi49 – 11769HMG boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: Ensembl
  2. DNA binding Source: UniProtKB
  3. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: Ensembl
  4. sequence-specific DNA binding transcription factor activity Source: UniProtKB

GO - Biological processi

  1. cell differentiation Source: BHF-UCL
  2. chromatin organization Source: UniProtKB
  3. male gonad development Source: ProtInc
  4. myoblast development Source: BHF-UCL
  5. negative regulation of striated muscle tissue development Source: BHF-UCL
  6. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  7. positive regulation of G0 to G1 transition Source: BHF-UCL
  8. positive regulation of myoblast proliferation Source: BHF-UCL
  9. positive regulation of satellite cell activation involved in skeletal muscle regeneration Source: BHF-UCL
  10. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  11. regulation of transcription, DNA-templated Source: UniProtKB
  12. regulation of transcription from RNA polymerase II promoter Source: ProtInc
  13. skeletal muscle tissue regeneration Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SOX-15
Alternative name(s):
Protein SOX-12
Protein SOX-20
Gene namesi
Name:SOX15
Synonyms:SOX12, SOX20, SOX26, SOX27
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:11196. SOX15.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nuclear transcription factor complex Source: Ensembl
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36033.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 233233Protein SOX-15PRO_0000048762Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei37 – 371Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO60248.
PaxDbiO60248.
PRIDEiO60248.

PTM databases

PhosphoSiteiO60248.

Expressioni

Tissue specificityi

Widely expressed in fetal and adult tissues examined, highest level found in fetal spinal cord and adult brain and testis.2 Publications

Gene expression databases

BgeeiO60248.
CleanExiHS_SOX12.
HS_SOX15.
GenevestigatoriO60248.

Organism-specific databases

HPAiHPA067196.

Interactioni

Protein-protein interaction databases

BioGridi112548. 3 interactions.
STRINGi9606.ENSP00000355354.

Structurei

3D structure databases

ProteinModelPortaliO60248.
SMRiO60248. Positions 47-123.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG311451.
GeneTreeiENSGT00760000118988.
HOGENOMiHOG000231647.
HOVERGENiHBG055512.
InParanoidiO60248.
KOiK09271.
OMAiYGSSHCK.
OrthoDBiEOG7H793V.
PhylomeDBiO60248.
TreeFamiTF351735.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O60248-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALPGSSQDQ AWSLEPPAAT AAASSSSGPQ EREGAGSPAA PGTLPLEKVK
60 70 80 90 100
RPMNAFMVWS SAQRRQMAQQ NPKMHNSEIS KRLGAQWKLL DEDEKRPFVE
110 120 130 140 150
EAKRLRARHL RDYPDYKYRP RRKAKSSGAG PSRCGQGRGN LASGGPLWGP
160 170 180 190 200
GYATTQPSRG FGYRPPSYST AYLPGSYGSS HCKLEAPSPC SLPQSDPRLQ
210 220 230
GELLPTYTHY LPPGSPTPYN PPLAGAPMPL THL
Length:233
Mass (Da):25,251
Last modified:July 31, 1998 - v1
Checksum:i6B52AE455C7C8CCE
GO
Isoform 2 (identifier: O60248-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     179-233: Missing.

Note: No experimental confirmation available.

Show »
Length:178
Mass (Da):19,393
Checksum:i82400844712B1E2D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 273SSS → AAA (PubMed:8978787).Curated
Sequence conflicti69 – 702QQ → HE in CAA51520 (PubMed:8332506).Curated
Sequence conflicti191 – 1911S → F in BAA78784 (Ref. 9) Curated
Sequence conflicti216 – 2183PTP → STS in BAA78784 (Ref. 9) Curated
Sequence conflicti225 – 2262GA → VP in BAA78784 (Ref. 9) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei179 – 23355Missing in isoform 2. 1 PublicationVSP_056668Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006867 mRNA. Translation: BAA25663.1.
AK301687 mRNA. Translation: BAG63159.1.
AC016876 Genomic DNA. No translation available.
CH471108 Genomic DNA. Translation: EAW90156.1.
CH471108 Genomic DNA. Translation: EAW90157.1.
BC000985 mRNA. Translation: AAH00985.1.
BC072003 mRNA. Translation: AAH72003.1.
X73039 Genomic DNA. Translation: CAA51520.1.
AJ006222 mRNA. Translation: CAA06920.1.
AB025355 Genomic DNA. Translation: BAA78784.1.
CCDSiCCDS32549.1. [O60248-1]
PIRiS34119.
RefSeqiNP_008873.1. NM_006942.1. [O60248-1]
UniGeneiHs.95582.

Genome annotation databases

EnsembliENST00000250055; ENSP00000355354; ENSG00000129194. [O60248-1]
ENST00000538513; ENSP00000439311; ENSG00000129194. [O60248-1]
ENST00000570788; ENSP00000458286; ENSG00000129194. [O60248-2]
GeneIDi6665.
KEGGihsa:6665.
UCSCiuc002ghy.1. human. [O60248-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006867 mRNA. Translation: BAA25663.1.
AK301687 mRNA. Translation: BAG63159.1.
AC016876 Genomic DNA. No translation available.
CH471108 Genomic DNA. Translation: EAW90156.1.
CH471108 Genomic DNA. Translation: EAW90157.1.
BC000985 mRNA. Translation: AAH00985.1.
BC072003 mRNA. Translation: AAH72003.1.
X73039 Genomic DNA. Translation: CAA51520.1.
AJ006222 mRNA. Translation: CAA06920.1.
AB025355 Genomic DNA. Translation: BAA78784.1.
CCDSiCCDS32549.1. [O60248-1]
PIRiS34119.
RefSeqiNP_008873.1. NM_006942.1. [O60248-1]
UniGeneiHs.95582.

3D structure databases

ProteinModelPortaliO60248.
SMRiO60248. Positions 47-123.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112548. 3 interactions.
STRINGi9606.ENSP00000355354.

PTM databases

PhosphoSiteiO60248.

Proteomic databases

MaxQBiO60248.
PaxDbiO60248.
PRIDEiO60248.

Protocols and materials databases

DNASUi6665.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000250055; ENSP00000355354; ENSG00000129194. [O60248-1]
ENST00000538513; ENSP00000439311; ENSG00000129194. [O60248-1]
ENST00000570788; ENSP00000458286; ENSG00000129194. [O60248-2]
GeneIDi6665.
KEGGihsa:6665.
UCSCiuc002ghy.1. human. [O60248-1]

Organism-specific databases

CTDi6665.
GeneCardsiGC17M007491.
HGNCiHGNC:11196. SOX15.
HPAiHPA067196.
MIMi601297. gene.
neXtProtiNX_O60248.
PharmGKBiPA36033.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG311451.
GeneTreeiENSGT00760000118988.
HOGENOMiHOG000231647.
HOVERGENiHBG055512.
InParanoidiO60248.
KOiK09271.
OMAiYGSSHCK.
OrthoDBiEOG7H793V.
PhylomeDBiO60248.
TreeFamiTF351735.

Miscellaneous databases

GeneWikiiSOX15.
GenomeRNAii6665.
NextBioi25987.
PROiO60248.
SOURCEiSearch...

Gene expression databases

BgeeiO60248.
CleanExiHS_SOX12.
HS_SOX15.
GenevestigatoriO60248.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Esophagus.
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  6. "SOX20, a new member of the SOX gene family, is located on chromosome 17p13."
    Meyer J., Wirth J., Held M., Schempp W., Scherer G.
    Cytogenet. Cell Genet. 72:246-249(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 1-178, TISSUE SPECIFICITY.
    Tissue: Fetal brain.
  7. "Partial cloning of SOX-11 and SOX-12, two new human SOX genes."
    Goze C., Poulat F., Berta P.
    Nucleic Acids Res. 21:2943-2943(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 57-115.
  8. "cDNA characterization and high resolution mapping of the human SOX20 gene."
    Vujic M., Rajic T., Goodfellow P.N., Stevanovic M.
    Mamm. Genome 9:1059-1061(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 92-233 (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Brain.
  9. "Human SL15 gene, 3'UTR and SOX 20 gene, partial cds."
    Miyashita A., Shimizu N., Odani S., Nakajima T., Kuwano R.
    Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 179-233.
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSOX15_HUMAN
AccessioniPrimary (citable) accession number: O60248
Secondary accession number(s): B4DWU7
, D3DTQ0, P35717, Q9Y6W7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 14, 1998
Last sequence update: July 31, 1998
Last modified: March 3, 2015
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.