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O60248

- SOX15_HUMAN

UniProt

O60248 - SOX15_HUMAN

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Protein
Protein SOX-15
Gene
SOX15, SOX12, SOX20, SOX26, SOX27
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Binds to the 5'-AACAAT-3' sequence.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi49 – 11769HMG box
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. chromatin binding Source: Ensembl
  3. sequence-specific DNA binding transcription factor activity Source: UniProtKB

GO - Biological processi

  1. cell differentiation Source: BHF-UCL
  2. chromatin organization Source: UniProtKB
  3. male gonad development Source: ProtInc
  4. myoblast development Source: BHF-UCL
  5. negative regulation of striated muscle tissue development Source: BHF-UCL
  6. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  7. positive regulation of G0 to G1 transition Source: BHF-UCL
  8. positive regulation of myoblast proliferation Source: BHF-UCL
  9. positive regulation of satellite cell activation involved in skeletal muscle regeneration Source: BHF-UCL
  10. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  11. regulation of transcription from RNA polymerase II promoter Source: ProtInc
  12. regulation of transcription, DNA-templated Source: UniProtKB
  13. skeletal muscle tissue regeneration Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SOX-15
Alternative name(s):
Protein SOX-12
Protein SOX-20
Gene namesi
Name:SOX15
Synonyms:SOX12, SOX20, SOX26, SOX27
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:11196. SOX15.

Subcellular locationi

Nucleus Reviewed prediction

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36033.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 233233Protein SOX-15
PRO_0000048762Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei37 – 371Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO60248.
PaxDbiO60248.
PRIDEiO60248.

PTM databases

PhosphoSiteiO60248.

Expressioni

Tissue specificityi

Widely expressed in fetal and adult tissues examined, highest level found in fetal spinal cord and adult brain and testis.2 Publications

Gene expression databases

ArrayExpressiO60248.
BgeeiO60248.
CleanExiHS_SOX12.
HS_SOX15.
GenevestigatoriO60248.

Interactioni

Protein-protein interaction databases

BioGridi112548. 1 interaction.
STRINGi9606.ENSP00000355354.

Structurei

3D structure databases

ProteinModelPortaliO60248.
SMRiO60248. Positions 47-123.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG311451.
HOGENOMiHOG000231647.
HOVERGENiHBG055512.
InParanoidiO60248.
KOiK09271.
OMAiYGSSHCK.
OrthoDBiEOG7H793V.
PhylomeDBiO60248.
TreeFamiTF351735.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O60248-1 [UniParc]FASTAAdd to Basket

« Hide

MALPGSSQDQ AWSLEPPAAT AAASSSSGPQ EREGAGSPAA PGTLPLEKVK    50
RPMNAFMVWS SAQRRQMAQQ NPKMHNSEIS KRLGAQWKLL DEDEKRPFVE 100
EAKRLRARHL RDYPDYKYRP RRKAKSSGAG PSRCGQGRGN LASGGPLWGP 150
GYATTQPSRG FGYRPPSYST AYLPGSYGSS HCKLEAPSPC SLPQSDPRLQ 200
GELLPTYTHY LPPGSPTPYN PPLAGAPMPL THL 233
Length:233
Mass (Da):25,251
Last modified:August 1, 1998 - v1
Checksum:i6B52AE455C7C8CCE
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 273SSS → AAA1 Publication
Sequence conflicti69 – 702QQ → HE in CAA51520. 1 Publication
Sequence conflicti191 – 1911S → F in BAA78784. 1 Publication
Sequence conflicti216 – 2183PTP → STS in BAA78784. 1 Publication
Sequence conflicti225 – 2262GA → VP in BAA78784. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB006867 mRNA. Translation: BAA25663.1.
CH471108 Genomic DNA. Translation: EAW90156.1.
CH471108 Genomic DNA. Translation: EAW90157.1.
BC000985 mRNA. Translation: AAH00985.1.
BC072003 mRNA. Translation: AAH72003.1.
X73039 Genomic DNA. Translation: CAA51520.1.
AJ006222 mRNA. Translation: CAA06920.1.
AB025355 Genomic DNA. Translation: BAA78784.1.
CCDSiCCDS32549.1.
PIRiS34119.
RefSeqiNP_008873.1. NM_006942.1.
UniGeneiHs.95582.

Genome annotation databases

EnsembliENST00000250055; ENSP00000355354; ENSG00000129194.
ENST00000538513; ENSP00000439311; ENSG00000129194.
GeneIDi6665.
KEGGihsa:6665.
UCSCiuc002ghy.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB006867 mRNA. Translation: BAA25663.1 .
CH471108 Genomic DNA. Translation: EAW90156.1 .
CH471108 Genomic DNA. Translation: EAW90157.1 .
BC000985 mRNA. Translation: AAH00985.1 .
BC072003 mRNA. Translation: AAH72003.1 .
X73039 Genomic DNA. Translation: CAA51520.1 .
AJ006222 mRNA. Translation: CAA06920.1 .
AB025355 Genomic DNA. Translation: BAA78784.1 .
CCDSi CCDS32549.1.
PIRi S34119.
RefSeqi NP_008873.1. NM_006942.1.
UniGenei Hs.95582.

3D structure databases

ProteinModelPortali O60248.
SMRi O60248. Positions 47-123.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112548. 1 interaction.
STRINGi 9606.ENSP00000355354.

PTM databases

PhosphoSitei O60248.

Proteomic databases

MaxQBi O60248.
PaxDbi O60248.
PRIDEi O60248.

Protocols and materials databases

DNASUi 6665.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000250055 ; ENSP00000355354 ; ENSG00000129194 .
ENST00000538513 ; ENSP00000439311 ; ENSG00000129194 .
GeneIDi 6665.
KEGGi hsa:6665.
UCSCi uc002ghy.1. human.

Organism-specific databases

CTDi 6665.
GeneCardsi GC17M007491.
HGNCi HGNC:11196. SOX15.
MIMi 601297. gene.
neXtProti NX_O60248.
PharmGKBi PA36033.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG311451.
HOGENOMi HOG000231647.
HOVERGENi HBG055512.
InParanoidi O60248.
KOi K09271.
OMAi YGSSHCK.
OrthoDBi EOG7H793V.
PhylomeDBi O60248.
TreeFami TF351735.

Miscellaneous databases

GeneWikii SOX15.
GenomeRNAii 6665.
NextBioi 25987.
PROi O60248.
SOURCEi Search...

Gene expression databases

ArrayExpressi O60248.
Bgeei O60248.
CleanExi HS_SOX12.
HS_SOX15.
Genevestigatori O60248.

Family and domain databases

Gene3Di 1.10.30.10. 1 hit.
InterProi IPR009071. HMG_box_dom.
[Graphical view ]
Pfami PF00505. HMG_box. 1 hit.
[Graphical view ]
SMARTi SM00398. HMG. 1 hit.
[Graphical view ]
SUPFAMi SSF47095. SSF47095. 1 hit.
PROSITEi PS50118. HMG_BOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  4. "SOX20, a new member of the SOX gene family, is located on chromosome 17p13."
    Meyer J., Wirth J., Held M., Schempp W., Scherer G.
    Cytogenet. Cell Genet. 72:246-249(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 1-178, TISSUE SPECIFICITY.
    Tissue: Fetal brain.
  5. "Partial cloning of SOX-11 and SOX-12, two new human SOX genes."
    Goze C., Poulat F., Berta P.
    Nucleic Acids Res. 21:2943-2943(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 57-115.
  6. "cDNA characterization and high resolution mapping of the human SOX20 gene."
    Vujic M., Rajic T., Goodfellow P.N., Stevanovic M.
    Mamm. Genome 9:1059-1061(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 92-233, TISSUE SPECIFICITY.
    Tissue: Brain.
  7. "Human SL15 gene, 3'UTR and SOX 20 gene, partial cds."
    Miyashita A., Shimizu N., Odani S., Nakajima T., Kuwano R.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 179-233.
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSOX15_HUMAN
AccessioniPrimary (citable) accession number: O60248
Secondary accession number(s): D3DTQ0, P35717, Q9Y6W7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: July 9, 2014
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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