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O60248 (SOX15_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 132. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein SOX-15
Alternative name(s):
Protein SOX-12
Protein SOX-20
Gene names
Name:SOX15
Synonyms:SOX12, SOX20, SOX26, SOX27
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length233 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds to the 5'-AACAAT-3' sequence.

Subcellular location

Nucleus Potential.

Tissue specificity

Widely expressed in fetal and adult tissues examined, highest level found in fetal spinal cord and adult brain and testis. Ref.4 Ref.6

Sequence similarities

Contains 1 HMG box DNA-binding domain.

Ontologies

Keywords
   Cellular componentNucleus
   LigandDNA-binding
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell differentiation

Inferred from sequence or structural similarity PubMed 16759287. Source: BHF-UCL

chromatin organization

Non-traceable author statement Ref.5. Source: UniProtKB

male gonad development

Traceable author statement Ref.1. Source: ProtInc

myoblast development

Inferred from sequence or structural similarity PubMed 15367664. Source: BHF-UCL

negative regulation of striated muscle tissue development

Inferred from sequence or structural similarity PubMed 10821863. Source: BHF-UCL

negative regulation of transcription from RNA polymerase II promoter

Inferred from sequence or structural similarity PubMed 17363903. Source: BHF-UCL

positive regulation of G0 to G1 transition

Inferred from sequence or structural similarity PubMed 17363903. Source: BHF-UCL

positive regulation of myoblast proliferation

Inferred from sequence or structural similarity PubMed 17363903. Source: BHF-UCL

positive regulation of satellite cell activation involved in skeletal muscle regeneration

Inferred from sequence or structural similarity PubMed 17363903. Source: BHF-UCL

positive regulation of transcription from RNA polymerase II promoter

Inferred from sequence or structural similarity PubMed 17363903. Source: BHF-UCL

regulation of transcription from RNA polymerase II promoter

Traceable author statement Ref.1. Source: ProtInc

regulation of transcription, DNA-templated

Non-traceable author statement Ref.5. Source: UniProtKB

skeletal muscle tissue regeneration

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: Ensembl

nucleus

Non-traceable author statement Ref.5. Source: UniProtKB

   Molecular_functionDNA binding

Non-traceable author statement Ref.5. Source: UniProtKB

chromatin binding

Inferred from electronic annotation. Source: Ensembl

sequence-specific DNA binding transcription factor activity

Non-traceable author statement Ref.5. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 233233Protein SOX-15
PRO_0000048762

Regions

DNA binding49 – 11769HMG box

Amino acid modifications

Modified residue371Phosphoserine Ref.8

Experimental info

Sequence conflict25 – 273SSS → AAA Ref.4
Sequence conflict69 – 702QQ → HE in CAA51520. Ref.5
Sequence conflict1911S → F in BAA78784. Ref.7
Sequence conflict216 – 2183PTP → STS in BAA78784. Ref.7
Sequence conflict225 – 2262GA → VP in BAA78784. Ref.7

Sequences

Sequence LengthMass (Da)Tools
O60248 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 6B52AE455C7C8CCE

FASTA23325,251
        10         20         30         40         50         60 
MALPGSSQDQ AWSLEPPAAT AAASSSSGPQ EREGAGSPAA PGTLPLEKVK RPMNAFMVWS 

        70         80         90        100        110        120 
SAQRRQMAQQ NPKMHNSEIS KRLGAQWKLL DEDEKRPFVE EAKRLRARHL RDYPDYKYRP 

       130        140        150        160        170        180 
RRKAKSSGAG PSRCGQGRGN LASGGPLWGP GYATTQPSRG FGYRPPSYST AYLPGSYGSS 

       190        200        210        220        230 
HCKLEAPSPC SLPQSDPRLQ GELLPTYTHY LPPGSPTPYN PPLAGAPMPL THL 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and expression of a human SRY-related cDNA hSOX20."
Hiraoka Y., Ogawa M., Sakai Y., Taniguchi K., Fujii T., Umezawa A., Hata J., Aiso S.
Biochim. Biophys. Acta 1396:132-137(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[4]"SOX20, a new member of the SOX gene family, is located on chromosome 17p13."
Meyer J., Wirth J., Held M., Schempp W., Scherer G.
Cytogenet. Cell Genet. 72:246-249(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 1-178, TISSUE SPECIFICITY.
Tissue: Fetal brain.
[5]"Partial cloning of SOX-11 and SOX-12, two new human SOX genes."
Goze C., Poulat F., Berta P.
Nucleic Acids Res. 21:2943-2943(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 57-115.
[6]"cDNA characterization and high resolution mapping of the human SOX20 gene."
Vujic M., Rajic T., Goodfellow P.N., Stevanovic M.
Mamm. Genome 9:1059-1061(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 92-233, TISSUE SPECIFICITY.
Tissue: Brain.
[7]"Human SL15 gene, 3'UTR and SOX 20 gene, partial cds."
Miyashita A., Shimizu N., Odani S., Nakajima T., Kuwano R.
Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 179-233.
[8]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB006867 mRNA. Translation: BAA25663.1.
CH471108 Genomic DNA. Translation: EAW90156.1.
CH471108 Genomic DNA. Translation: EAW90157.1.
BC000985 mRNA. Translation: AAH00985.1.
BC072003 mRNA. Translation: AAH72003.1.
X73039 Genomic DNA. Translation: CAA51520.1.
AJ006222 mRNA. Translation: CAA06920.1.
AB025355 Genomic DNA. Translation: BAA78784.1.
CCDSCCDS32549.1.
PIRS34119.
RefSeqNP_008873.1. NM_006942.1.
UniGeneHs.95582.

3D structure databases

ProteinModelPortalO60248.
SMRO60248. Positions 47-123.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112548. 1 interaction.
STRING9606.ENSP00000355354.

PTM databases

PhosphoSiteO60248.

Proteomic databases

MaxQBO60248.
PaxDbO60248.
PRIDEO60248.

Protocols and materials databases

DNASU6665.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000250055; ENSP00000355354; ENSG00000129194.
ENST00000538513; ENSP00000439311; ENSG00000129194.
GeneID6665.
KEGGhsa:6665.
UCSCuc002ghy.1. human.

Organism-specific databases

CTD6665.
GeneCardsGC17M007491.
HGNCHGNC:11196. SOX15.
MIM601297. gene.
neXtProtNX_O60248.
PharmGKBPA36033.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG311451.
HOGENOMHOG000231647.
HOVERGENHBG055512.
InParanoidO60248.
KOK09271.
OMAYGSSHCK.
OrthoDBEOG7H793V.
PhylomeDBO60248.
TreeFamTF351735.

Gene expression databases

ArrayExpressO60248.
BgeeO60248.
CleanExHS_SOX12.
HS_SOX15.
GenevestigatorO60248.

Family and domain databases

Gene3D1.10.30.10. 1 hit.
InterProIPR009071. HMG_box_dom.
[Graphical view]
PfamPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMSSF47095. SSF47095. 1 hit.
PROSITEPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSOX15.
GenomeRNAi6665.
NextBio25987.
PROO60248.
SOURCESearch...

Entry information

Entry nameSOX15_HUMAN
AccessionPrimary (citable) accession number: O60248
Secondary accession number(s): D3DTQ0, P35717, Q9Y6W7
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: July 9, 2014
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM