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O60248

- SOX15_HUMAN

UniProt

O60248 - SOX15_HUMAN

Protein

Protein SOX-15

Gene

SOX15

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Binds to the 5'-AACAAT-3' sequence.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi49 – 11769HMG boxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: Ensembl
    2. DNA binding Source: UniProtKB
    3. sequence-specific DNA binding transcription factor activity Source: UniProtKB

    GO - Biological processi

    1. cell differentiation Source: BHF-UCL
    2. chromatin organization Source: UniProtKB
    3. male gonad development Source: ProtInc
    4. myoblast development Source: BHF-UCL
    5. negative regulation of striated muscle tissue development Source: BHF-UCL
    6. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    7. positive regulation of G0 to G1 transition Source: BHF-UCL
    8. positive regulation of myoblast proliferation Source: BHF-UCL
    9. positive regulation of satellite cell activation involved in skeletal muscle regeneration Source: BHF-UCL
    10. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    11. regulation of transcription, DNA-templated Source: UniProtKB
    12. regulation of transcription from RNA polymerase II promoter Source: ProtInc
    13. skeletal muscle tissue regeneration Source: Ensembl

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein SOX-15
    Alternative name(s):
    Protein SOX-12
    Protein SOX-20
    Gene namesi
    Name:SOX15
    Synonyms:SOX12, SOX20, SOX26, SOX27
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:11196. SOX15.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36033.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 233233Protein SOX-15PRO_0000048762Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei37 – 371Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiO60248.
    PaxDbiO60248.
    PRIDEiO60248.

    PTM databases

    PhosphoSiteiO60248.

    Expressioni

    Tissue specificityi

    Widely expressed in fetal and adult tissues examined, highest level found in fetal spinal cord and adult brain and testis.2 Publications

    Gene expression databases

    ArrayExpressiO60248.
    BgeeiO60248.
    CleanExiHS_SOX12.
    HS_SOX15.
    GenevestigatoriO60248.

    Interactioni

    Protein-protein interaction databases

    BioGridi112548. 1 interaction.
    STRINGi9606.ENSP00000355354.

    Structurei

    3D structure databases

    ProteinModelPortaliO60248.
    SMRiO60248. Positions 47-123.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG311451.
    HOGENOMiHOG000231647.
    HOVERGENiHBG055512.
    InParanoidiO60248.
    KOiK09271.
    OMAiYGSSHCK.
    OrthoDBiEOG7H793V.
    PhylomeDBiO60248.
    TreeFamiTF351735.

    Family and domain databases

    Gene3Di1.10.30.10. 1 hit.
    InterProiIPR009071. HMG_box_dom.
    [Graphical view]
    PfamiPF00505. HMG_box. 1 hit.
    [Graphical view]
    SMARTiSM00398. HMG. 1 hit.
    [Graphical view]
    SUPFAMiSSF47095. SSF47095. 1 hit.
    PROSITEiPS50118. HMG_BOX_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O60248-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MALPGSSQDQ AWSLEPPAAT AAASSSSGPQ EREGAGSPAA PGTLPLEKVK    50
    RPMNAFMVWS SAQRRQMAQQ NPKMHNSEIS KRLGAQWKLL DEDEKRPFVE 100
    EAKRLRARHL RDYPDYKYRP RRKAKSSGAG PSRCGQGRGN LASGGPLWGP 150
    GYATTQPSRG FGYRPPSYST AYLPGSYGSS HCKLEAPSPC SLPQSDPRLQ 200
    GELLPTYTHY LPPGSPTPYN PPLAGAPMPL THL 233
    Length:233
    Mass (Da):25,251
    Last modified:August 1, 1998 - v1
    Checksum:i6B52AE455C7C8CCE
    GO
    Isoform 2 (identifier: O60248-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         179-233: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:178
    Mass (Da):19,393
    Checksum:i82400844712B1E2D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti25 – 273SSS → AAA(PubMed:8978787)Curated
    Sequence conflicti69 – 702QQ → HE in CAA51520. (PubMed:8332506)Curated
    Sequence conflicti191 – 1911S → F in BAA78784. 1 PublicationCurated
    Sequence conflicti216 – 2183PTP → STS in BAA78784. 1 PublicationCurated
    Sequence conflicti225 – 2262GA → VP in BAA78784. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei179 – 23355Missing in isoform 2. 1 PublicationVSP_056668Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB006867 mRNA. Translation: BAA25663.1.
    AK301687 mRNA. Translation: BAG63159.1.
    AC016876 Genomic DNA. No translation available.
    CH471108 Genomic DNA. Translation: EAW90156.1.
    CH471108 Genomic DNA. Translation: EAW90157.1.
    BC000985 mRNA. Translation: AAH00985.1.
    BC072003 mRNA. Translation: AAH72003.1.
    X73039 Genomic DNA. Translation: CAA51520.1.
    AJ006222 mRNA. Translation: CAA06920.1.
    AB025355 Genomic DNA. Translation: BAA78784.1.
    CCDSiCCDS32549.1.
    PIRiS34119.
    RefSeqiNP_008873.1. NM_006942.1.
    UniGeneiHs.95582.

    Genome annotation databases

    EnsembliENST00000250055; ENSP00000355354; ENSG00000129194.
    ENST00000538513; ENSP00000439311; ENSG00000129194.
    ENST00000570788; ENSP00000458286; ENSG00000129194.
    GeneIDi6665.
    KEGGihsa:6665.
    UCSCiuc002ghy.1. human.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB006867 mRNA. Translation: BAA25663.1 .
    AK301687 mRNA. Translation: BAG63159.1 .
    AC016876 Genomic DNA. No translation available.
    CH471108 Genomic DNA. Translation: EAW90156.1 .
    CH471108 Genomic DNA. Translation: EAW90157.1 .
    BC000985 mRNA. Translation: AAH00985.1 .
    BC072003 mRNA. Translation: AAH72003.1 .
    X73039 Genomic DNA. Translation: CAA51520.1 .
    AJ006222 mRNA. Translation: CAA06920.1 .
    AB025355 Genomic DNA. Translation: BAA78784.1 .
    CCDSi CCDS32549.1.
    PIRi S34119.
    RefSeqi NP_008873.1. NM_006942.1.
    UniGenei Hs.95582.

    3D structure databases

    ProteinModelPortali O60248.
    SMRi O60248. Positions 47-123.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112548. 1 interaction.
    STRINGi 9606.ENSP00000355354.

    PTM databases

    PhosphoSitei O60248.

    Proteomic databases

    MaxQBi O60248.
    PaxDbi O60248.
    PRIDEi O60248.

    Protocols and materials databases

    DNASUi 6665.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000250055 ; ENSP00000355354 ; ENSG00000129194 .
    ENST00000538513 ; ENSP00000439311 ; ENSG00000129194 .
    ENST00000570788 ; ENSP00000458286 ; ENSG00000129194 .
    GeneIDi 6665.
    KEGGi hsa:6665.
    UCSCi uc002ghy.1. human.

    Organism-specific databases

    CTDi 6665.
    GeneCardsi GC17M007491.
    HGNCi HGNC:11196. SOX15.
    MIMi 601297. gene.
    neXtProti NX_O60248.
    PharmGKBi PA36033.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG311451.
    HOGENOMi HOG000231647.
    HOVERGENi HBG055512.
    InParanoidi O60248.
    KOi K09271.
    OMAi YGSSHCK.
    OrthoDBi EOG7H793V.
    PhylomeDBi O60248.
    TreeFami TF351735.

    Miscellaneous databases

    GeneWikii SOX15.
    GenomeRNAii 6665.
    NextBioi 25987.
    PROi O60248.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O60248.
    Bgeei O60248.
    CleanExi HS_SOX12.
    HS_SOX15.
    Genevestigatori O60248.

    Family and domain databases

    Gene3Di 1.10.30.10. 1 hit.
    InterProi IPR009071. HMG_box_dom.
    [Graphical view ]
    Pfami PF00505. HMG_box. 1 hit.
    [Graphical view ]
    SMARTi SM00398. HMG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47095. SSF47095. 1 hit.
    PROSITEi PS50118. HMG_BOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Esophagus.
    3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Placenta.
    6. "SOX20, a new member of the SOX gene family, is located on chromosome 17p13."
      Meyer J., Wirth J., Held M., Schempp W., Scherer G.
      Cytogenet. Cell Genet. 72:246-249(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 1-178, TISSUE SPECIFICITY.
      Tissue: Fetal brain.
    7. "Partial cloning of SOX-11 and SOX-12, two new human SOX genes."
      Goze C., Poulat F., Berta P.
      Nucleic Acids Res. 21:2943-2943(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 57-115.
    8. "cDNA characterization and high resolution mapping of the human SOX20 gene."
      Vujic M., Rajic T., Goodfellow P.N., Stevanovic M.
      Mamm. Genome 9:1059-1061(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 92-233 (ISOFORM 1), TISSUE SPECIFICITY.
      Tissue: Brain.
    9. "Human SL15 gene, 3'UTR and SOX 20 gene, partial cds."
      Miyashita A., Shimizu N., Odani S., Nakajima T., Kuwano R.
      Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 179-233.
    10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSOX15_HUMAN
    AccessioniPrimary (citable) accession number: O60248
    Secondary accession number(s): B4DWU7
    , D3DTQ0, P35717, Q9Y6W7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 133 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3