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Protein

Protocadherin-7

Gene

PCDH7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion
LigandCalcium

Enzyme and pathway databases

ReactomeiR-HSA-114608. Platelet degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin-7
Alternative name(s):
Brain-heart protocadherin
Short name:
BH-Pcdh
Gene namesi
Name:PCDH7
Synonyms:BHPCDH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000169851.15.
HGNCiHGNC:8659. PCDH7.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 879ExtracellularSequence analysisAdd BLAST851
Transmembranei880 – 900HelicalSequence analysisAdd BLAST21
Topological domaini901 – 1069CytoplasmicSequence analysisAdd BLAST169

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5099.
OpenTargetsiENSG00000169851.
PharmGKBiPA33006.

Polymorphism and mutation databases

BioMutaiPCDH7.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000000399229 – 1069Protocadherin-7Add BLAST1041

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi79N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi689N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi747N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi780N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi822N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi840N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi845N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei989PhosphoserineCombined sources1
Modified residuei1011PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiO60245.
MaxQBiO60245.
PaxDbiO60245.
PeptideAtlasiO60245.
PRIDEiO60245.

PTM databases

iPTMnetiO60245.
PhosphoSitePlusiO60245.

Expressioni

Tissue specificityi

Expressed predominantly in brain and heart and at lower levels in various other tissues.

Gene expression databases

BgeeiENSG00000169851.
CleanExiHS_PCDH7.
ExpressionAtlasiO60245. baseline and differential.
GenevisibleiO60245. HS.

Organism-specific databases

HPAiHPA011866.
HPA046521.

Interactioni

Protein-protein interaction databases

BioGridi111132. 45 interactors.
IntActiO60245. 15 interactors.
STRINGi9606.ENSP00000441802.

Structurei

Secondary structure

11069
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi309 – 318Combined sources10
Beta strandi326 – 329Combined sources4
Beta strandi335 – 338Combined sources4
Helixi354 – 357Combined sources4
Beta strandi358 – 360Combined sources3
Turni362 – 364Combined sources3
Beta strandi366 – 369Combined sources4
Turni375 – 377Combined sources3
Beta strandi379 – 387Combined sources9
Turni391 – 394Combined sources4
Beta strandi397 – 406Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YSTNMR-A302-413[»]
ProteinModelPortaliO60245.
SMRiO60245.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO60245.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 143Cadherin 1PROSITE-ProRule annotationAdd BLAST115
Domaini144 – 308Cadherin 2PROSITE-ProRule annotationAdd BLAST165
Domaini309 – 415Cadherin 3PROSITE-ProRule annotationAdd BLAST107
Domaini424 – 535Cadherin 4PROSITE-ProRule annotationAdd BLAST112
Domaini536 – 639Cadherin 5PROSITE-ProRule annotationAdd BLAST104
Domaini640 – 742Cadherin 6PROSITE-ProRule annotationAdd BLAST103
Domaini745 – 862Cadherin 7PROSITE-ProRule annotationAdd BLAST118

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II7Q. Eukaryota.
ENOG410XPHP. LUCA.
GeneTreeiENSGT00890000139339.
HOGENOMiHOG000234535.
HOVERGENiHBG053523.
InParanoidiO60245.
KOiK16498.
OMAiPRSSQAI.
OrthoDBiEOG091G011P.
PhylomeDBiO60245.

Family and domain databases

InterProiView protein in InterPro
IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
IPR013585. Protocadherin.
PfamiView protein in Pfam
PF00028. Cadherin. 6 hits.
PF08266. Cadherin_2. 1 hit.
PF08374. Protocadherin. 1 hit.
PRINTSiPR00205. CADHERIN.
SMARTiView protein in SMART
SM00112. CA. 7 hits.
SUPFAMiSSF49313. SSF49313. 8 hits.
PROSITEiView protein in PROSITE
PS00232. CADHERIN_1. 6 hits.
PS50268. CADHERIN_2. 7 hits.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: O60245-1) [UniParc]FASTAAdd to basket
Also known as: BH-Pcdh-a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLRMRTAGWA RGWCLGCCLL LPLSLSLAAA KQLLRYRLAE EGPADVRIGN
60 70 80 90 100
VASDLGIVTG SGEVTFSLES GSEYLKIDNL TGELSTSERR IDREKLPQCQ
110 120 130 140 150
MIFDENECFL DFEVSVIGPS QSWVDLFEGQ VIVLDINDNT PTFPSPVLTL
160 170 180 190 200
TVEENRPVGT LYLLPTATDR DFGRNGIERY ELLQEPGGGG SGGESRRAGA
210 220 230 240 250
ADSAPYPGGG GNGASGGGSG GSKRRLDASE GGGGTNPGGR SSVFELQVAD
260 270 280 290 300
TPDGEKQPQL IVKGALDREQ RDSYELTLRV RDGGDPPRSS QAILRVLITD
310 320 330 340 350
VNDNSPRFEK SVYEADLAEN SAPGTPILQL RAADLDVGVN GQIEYVFGAA
360 370 380 390 400
TESVRRLLRL DETSGWLSVL HRIDREEVNQ LRFTVMARDR GQPPKTDKAT
410 420 430 440 450
VVLNIKDEND NVPSIEIRKI GRIPLKDGVA NVAEDVLVDT PIALVQVSDR
460 470 480 490 500
DQGENGVVTC TVVGDVPFQL KPASDTEGDQ NKKKYFLHTS TPLDYEATRE
510 520 530 540 550
FNVVIVAVDS GSPSLSSNNS LIVKVGDTND NPPMFGQSVV EVYFPENNIP
560 570 580 590 600
GERVATVLAT DADSGKNAEI AYSLDSSVMG IFAIDPDSGD ILVNTVLDRE
610 620 630 640 650
QTDRYEFKVN AKDKGIPVLQ GSTTVIVQVA DKNDNDPKFM QDVFTFYVKE
660 670 680 690 700
NLQPNSPVGM VTVMDADKGR NAEMSLYIEE NNNIFSIEND TGTIYSTMSF
710 720 730 740 750
DREHQTTYTF RVKAVDGGDP PRSATATVSL FVMDENDNAP TVTLPKNISY
760 770 780 790 800
TLLPPSSNVR TVVATVLATD SDDGINADLN YSIVGGNPFK LFEIDPTSGV
810 820 830 840 850
VSLVGKLTQK HYGLHRLVVQ VNDSGQPSQS TTTLVHVFVN ESVSNATAID
860 870 880 890 900
SQIARSLHIP LTQDIAGDPS YEISKQRLSI VIGVVAGIMT VILIILIVVM
910 920 930 940 950
ARYCRSKNKN GYEAGKKDHE DFFTPQQHDK SKKPKKDKKN KKSKQPLYSS
960 970 980 990 1000
IVTVEASKPN GQRYDSVNEK LSDSPSMGRY RSVNGGPGSP DLARHYKSSS
1010 1020 1030 1040 1050
PLPTVQLHPQ SPTAGKKHQA VQDLPPANTF VGAGDNISIG SDHCSEYSCQ
1060
TNNKYSKQMR LHPYITVFG
Length:1,069
Mass (Da):116,071
Last modified:July 28, 2009 - v2
Checksum:i6150CAF0599D5DAF
GO
Isoform B (identifier: O60245-2) [UniParc]FASTAAdd to basket
Also known as: BH-Pcdh-b

The sequence of this isoform differs from the canonical sequence as follows:
     1059-1069: MRLHPYITVFG → VRCIPNIFKYPREG

Show »
Length:1,072
Mass (Da):116,429
Checksum:iB37D12C7A156AF39
GO

Sequence cautioni

The sequence BAA25196 differs from that shown. Aberrant splicing.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25L → F in BAA25194 (PubMed:9615233).Curated1
Sequence conflicti25L → F in BAA25195 (PubMed:9615233).Curated1
Sequence conflicti25L → F in BAA25196 (PubMed:9615233).Curated1
Sequence conflicti518N → K in BAA25194 (PubMed:9615233).Curated1
Sequence conflicti518N → K in BAA25195 (PubMed:9615233).Curated1
Sequence conflicti518N → K in BAA25196 (PubMed:9615233).Curated1
Sequence conflicti834L → V in BAA25194 (PubMed:9615233).Curated1
Sequence conflicti834L → V in BAA25195 (PubMed:9615233).Curated1
Sequence conflicti834L → V in BAA25196 (PubMed:9615233).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0007041059 – 1069MRLHPYITVFG → VRCIPNIFKYPREG in isoform B. 1 PublicationAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006755 mRNA. Translation: BAA25194.1.
AB006756 mRNA. Translation: BAA25195.1.
AB006757 mRNA. Translation: BAA25196.1. Sequence problems.
AC097716 Genomic DNA. No translation available.
AC098595 Genomic DNA. No translation available.
AC107394 Genomic DNA. No translation available.
AC110766 Genomic DNA. Translation: AAY40944.1.
AC112239 Genomic DNA. No translation available.
CCDSiCCDS33971.1. [O60245-1]
CCDS75116.1. [O60245-2]
PIRiT00041.
T00042.
RefSeqiNP_002580.2. NM_002589.2. [O60245-1]
NP_115832.1. NM_032456.2. [O60245-2]
UniGeneiHs.479439.

Genome annotation databases

EnsembliENST00000361762; ENSP00000355243; ENSG00000169851. [O60245-1]
ENST00000543491; ENSP00000441802; ENSG00000169851. [O60245-2]
GeneIDi5099.
KEGGihsa:5099.
UCSCiuc003gsk.2. human. [O60245-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPCDH7_HUMAN
AccessioniPrimary (citable) accession number: O60245
Secondary accession number(s): O60246, O60247, Q4W5C4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: July 28, 2009
Last modified: September 27, 2017
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references