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O60245

- PCDH7_HUMAN

UniProt

O60245 - PCDH7_HUMAN

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Protein

Protocadherin-7

Gene

PCDH7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. homophilic cell adhesion Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin-7
Alternative name(s):
Brain-heart protocadherin
Short name:
BH-Pcdh
Gene namesi
Name:PCDH7
Synonyms:BHPCDH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:8659. PCDH7.

Subcellular locationi

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33006.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence AnalysisAdd
BLAST
Chaini29 – 10691041Protocadherin-7PRO_0000003992Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi79 – 791N-linked (GlcNAc...)Sequence Analysis
Glycosylationi689 – 6891N-linked (GlcNAc...)Sequence Analysis
Glycosylationi747 – 7471N-linked (GlcNAc...)Sequence Analysis
Glycosylationi780 – 7801N-linked (GlcNAc...)Sequence Analysis
Glycosylationi822 – 8221N-linked (GlcNAc...)Sequence Analysis
Glycosylationi840 – 8401N-linked (GlcNAc...)Sequence Analysis
Glycosylationi845 – 8451N-linked (GlcNAc...)Sequence Analysis
Modified residuei989 – 9891Phosphoserine2 Publications
Modified residuei1011 – 10111Phosphoserine1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiO60245.
PaxDbiO60245.
PRIDEiO60245.

PTM databases

PhosphoSiteiO60245.

Expressioni

Tissue specificityi

Expressed predominantly in brain and heart and at lower levels in various other tissues.

Gene expression databases

BgeeiO60245.
CleanExiHS_PCDH7.
GenevestigatoriO60245.

Organism-specific databases

HPAiHPA011866.

Interactioni

Protein-protein interaction databases

BioGridi111132. 12 interactions.
STRINGi9606.ENSP00000330302.

Structurei

Secondary structure

1
1069
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi309 – 31810
Beta strandi326 – 3294
Beta strandi335 – 3384
Helixi354 – 3574
Beta strandi358 – 3603
Turni362 – 3643
Beta strandi366 – 3694
Turni375 – 3773
Beta strandi379 – 3879
Turni391 – 3944
Beta strandi397 – 40610

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2YSTNMR-A302-413[»]
ProteinModelPortaliO60245.
SMRiO60245. Positions 259-860.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO60245.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 879851ExtracellularSequence AnalysisAdd
BLAST
Topological domaini901 – 1069169CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei880 – 90021HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 143115Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini144 – 308165Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini309 – 415107Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini424 – 535112Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini536 – 639104Cadherin 5PROSITE-ProRule annotationAdd
BLAST
Domaini640 – 742103Cadherin 6PROSITE-ProRule annotationAdd
BLAST
Domaini745 – 862118Cadherin 7PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 7 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG148296.
GeneTreeiENSGT00760000118822.
HOGENOMiHOG000234535.
HOVERGENiHBG053523.
InParanoidiO60245.
KOiK16498.
OrthoDBiEOG7WMCHN.
PhylomeDBiO60245.

Family and domain databases

Gene3Di2.60.40.60. 8 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
IPR013585. Protocadherin.
[Graphical view]
PfamiPF00028. Cadherin. 6 hits.
PF08266. Cadherin_2. 1 hit.
PF08374. Protocadherin. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 7 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 8 hits.
PROSITEiPS00232. CADHERIN_1. 6 hits.
PS50268. CADHERIN_2. 7 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform A (identifier: O60245-1) [UniParc]FASTAAdd to Basket

Also known as: BH-Pcdh-a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLRMRTAGWA RGWCLGCCLL LPLSLSLAAA KQLLRYRLAE EGPADVRIGN
60 70 80 90 100
VASDLGIVTG SGEVTFSLES GSEYLKIDNL TGELSTSERR IDREKLPQCQ
110 120 130 140 150
MIFDENECFL DFEVSVIGPS QSWVDLFEGQ VIVLDINDNT PTFPSPVLTL
160 170 180 190 200
TVEENRPVGT LYLLPTATDR DFGRNGIERY ELLQEPGGGG SGGESRRAGA
210 220 230 240 250
ADSAPYPGGG GNGASGGGSG GSKRRLDASE GGGGTNPGGR SSVFELQVAD
260 270 280 290 300
TPDGEKQPQL IVKGALDREQ RDSYELTLRV RDGGDPPRSS QAILRVLITD
310 320 330 340 350
VNDNSPRFEK SVYEADLAEN SAPGTPILQL RAADLDVGVN GQIEYVFGAA
360 370 380 390 400
TESVRRLLRL DETSGWLSVL HRIDREEVNQ LRFTVMARDR GQPPKTDKAT
410 420 430 440 450
VVLNIKDEND NVPSIEIRKI GRIPLKDGVA NVAEDVLVDT PIALVQVSDR
460 470 480 490 500
DQGENGVVTC TVVGDVPFQL KPASDTEGDQ NKKKYFLHTS TPLDYEATRE
510 520 530 540 550
FNVVIVAVDS GSPSLSSNNS LIVKVGDTND NPPMFGQSVV EVYFPENNIP
560 570 580 590 600
GERVATVLAT DADSGKNAEI AYSLDSSVMG IFAIDPDSGD ILVNTVLDRE
610 620 630 640 650
QTDRYEFKVN AKDKGIPVLQ GSTTVIVQVA DKNDNDPKFM QDVFTFYVKE
660 670 680 690 700
NLQPNSPVGM VTVMDADKGR NAEMSLYIEE NNNIFSIEND TGTIYSTMSF
710 720 730 740 750
DREHQTTYTF RVKAVDGGDP PRSATATVSL FVMDENDNAP TVTLPKNISY
760 770 780 790 800
TLLPPSSNVR TVVATVLATD SDDGINADLN YSIVGGNPFK LFEIDPTSGV
810 820 830 840 850
VSLVGKLTQK HYGLHRLVVQ VNDSGQPSQS TTTLVHVFVN ESVSNATAID
860 870 880 890 900
SQIARSLHIP LTQDIAGDPS YEISKQRLSI VIGVVAGIMT VILIILIVVM
910 920 930 940 950
ARYCRSKNKN GYEAGKKDHE DFFTPQQHDK SKKPKKDKKN KKSKQPLYSS
960 970 980 990 1000
IVTVEASKPN GQRYDSVNEK LSDSPSMGRY RSVNGGPGSP DLARHYKSSS
1010 1020 1030 1040 1050
PLPTVQLHPQ SPTAGKKHQA VQDLPPANTF VGAGDNISIG SDHCSEYSCQ
1060
TNNKYSKQMR LHPYITVFG
Length:1,069
Mass (Da):116,071
Last modified:July 28, 2009 - v2
Checksum:i6150CAF0599D5DAF
GO
Isoform B (identifier: O60245-2) [UniParc]FASTAAdd to Basket

Also known as: BH-Pcdh-b

The sequence of this isoform differs from the canonical sequence as follows:
     1059-1069: MRLHPYITVFG → VRCIPNIFKYPREG

Show »
Length:1,072
Mass (Da):116,429
Checksum:iB37D12C7A156AF39
GO

Sequence cautioni

The sequence BAA25196.1 differs from that shown. Reason: Aberrant splicing.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 251L → F in BAA25194. (PubMed:9615233)Curated
Sequence conflicti25 – 251L → F in BAA25195. (PubMed:9615233)Curated
Sequence conflicti25 – 251L → F in BAA25196. (PubMed:9615233)Curated
Sequence conflicti518 – 5181N → K in BAA25194. (PubMed:9615233)Curated
Sequence conflicti518 – 5181N → K in BAA25195. (PubMed:9615233)Curated
Sequence conflicti518 – 5181N → K in BAA25196. (PubMed:9615233)Curated
Sequence conflicti834 – 8341L → V in BAA25194. (PubMed:9615233)Curated
Sequence conflicti834 – 8341L → V in BAA25195. (PubMed:9615233)Curated
Sequence conflicti834 – 8341L → V in BAA25196. (PubMed:9615233)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1059 – 106911MRLHPYITVFG → VRCIPNIFKYPREG in isoform B. 1 PublicationVSP_000704Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB006755 mRNA. Translation: BAA25194.1.
AB006756 mRNA. Translation: BAA25195.1.
AB006757 mRNA. Translation: BAA25196.1. Sequence problems.
AC097716 Genomic DNA. No translation available.
AC098595 Genomic DNA. No translation available.
AC107394 Genomic DNA. No translation available.
AC110766 Genomic DNA. Translation: AAY40944.1.
AC112239 Genomic DNA. No translation available.
CCDSiCCDS33971.1. [O60245-1]
CCDS75116.1. [O60245-2]
PIRiT00041.
T00042.
RefSeqiNP_002580.2. NM_002589.2. [O60245-1]
NP_115832.1. NM_032456.2. [O60245-2]
UniGeneiHs.479439.

Genome annotation databases

EnsembliENST00000361762; ENSP00000355243; ENSG00000169851. [O60245-1]
ENST00000543491; ENSP00000441802; ENSG00000169851. [O60245-2]
GeneIDi5099.
KEGGihsa:5099.
UCSCiuc003gsk.1. human. [O60245-1]
uc021xnc.1. human. [O60245-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB006755 mRNA. Translation: BAA25194.1 .
AB006756 mRNA. Translation: BAA25195.1 .
AB006757 mRNA. Translation: BAA25196.1 . Sequence problems.
AC097716 Genomic DNA. No translation available.
AC098595 Genomic DNA. No translation available.
AC107394 Genomic DNA. No translation available.
AC110766 Genomic DNA. Translation: AAY40944.1 .
AC112239 Genomic DNA. No translation available.
CCDSi CCDS33971.1. [O60245-1 ]
CCDS75116.1. [O60245-2 ]
PIRi T00041.
T00042.
RefSeqi NP_002580.2. NM_002589.2. [O60245-1 ]
NP_115832.1. NM_032456.2. [O60245-2 ]
UniGenei Hs.479439.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2YST NMR - A 302-413 [» ]
ProteinModelPortali O60245.
SMRi O60245. Positions 259-860.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111132. 12 interactions.
STRINGi 9606.ENSP00000330302.

PTM databases

PhosphoSitei O60245.

Proteomic databases

MaxQBi O60245.
PaxDbi O60245.
PRIDEi O60245.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000361762 ; ENSP00000355243 ; ENSG00000169851 . [O60245-1 ]
ENST00000543491 ; ENSP00000441802 ; ENSG00000169851 . [O60245-2 ]
GeneIDi 5099.
KEGGi hsa:5099.
UCSCi uc003gsk.1. human. [O60245-1 ]
uc021xnc.1. human. [O60245-2 ]

Organism-specific databases

CTDi 5099.
GeneCardsi GC04P030722.
H-InvDB HIX0024543.
HGNCi HGNC:8659. PCDH7.
HPAi HPA011866.
MIMi 602988. gene.
neXtProti NX_O60245.
PharmGKBi PA33006.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG148296.
GeneTreei ENSGT00760000118822.
HOGENOMi HOG000234535.
HOVERGENi HBG053523.
InParanoidi O60245.
KOi K16498.
OrthoDBi EOG7WMCHN.
PhylomeDBi O60245.

Miscellaneous databases

ChiTaRSi PCDH7. human.
EvolutionaryTracei O60245.
GeneWikii PCDH7.
GenomeRNAii 5099.
NextBioi 19678.
PROi O60245.
SOURCEi Search...

Gene expression databases

Bgeei O60245.
CleanExi HS_PCDH7.
Genevestigatori O60245.

Family and domain databases

Gene3Di 2.60.40.60. 8 hits.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
IPR013585. Protocadherin.
[Graphical view ]
Pfami PF00028. Cadherin. 6 hits.
PF08266. Cadherin_2. 1 hit.
PF08374. Protocadherin. 1 hit.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
SMARTi SM00112. CA. 7 hits.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 8 hits.
PROSITEi PS00232. CADHERIN_1. 6 hits.
PS50268. CADHERIN_2. 7 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, expression analysis, and chromosomal localization of BH-protocadherin (PCDH7), a novel member of the cadherin superfamily."
    Yoshida K., Yoshitomo-Nakagawa K., Seki N., Sasaki M., Sugano S.
    Genomics 49:458-461(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B).
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-989 AND SER-1011, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  4. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-989, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Solution structure of the third cadherin domain from human protocadherin 7."
    RIKEN structural genomics initiative (RSGI)
    Submitted (OCT-2007) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 302-413.

Entry informationi

Entry nameiPCDH7_HUMAN
AccessioniPrimary (citable) accession number: O60245
Secondary accession number(s): O60246, O60247, Q4W5C4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: July 28, 2009
Last modified: October 29, 2014
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3