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O60245

- PCDH7_HUMAN

UniProt

O60245 - PCDH7_HUMAN

Protein

Protocadherin-7

Gene

PCDH7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 2 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. homophilic cell adhesion Source: InterPro

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protocadherin-7
    Alternative name(s):
    Brain-heart protocadherin
    Short name:
    BH-Pcdh
    Gene namesi
    Name:PCDH7
    Synonyms:BHPCDH
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:8659. PCDH7.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33006.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2828Sequence AnalysisAdd
    BLAST
    Chaini29 – 10691041Protocadherin-7PRO_0000003992Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi79 – 791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi689 – 6891N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi747 – 7471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi780 – 7801N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi822 – 8221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi840 – 8401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi845 – 8451N-linked (GlcNAc...)Sequence Analysis
    Modified residuei989 – 9891Phosphoserine2 Publications
    Modified residuei1011 – 10111Phosphoserine1 Publication

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiO60245.
    PaxDbiO60245.
    PRIDEiO60245.

    PTM databases

    PhosphoSiteiO60245.

    Expressioni

    Tissue specificityi

    Expressed predominantly in brain and heart and at lower levels in various other tissues.

    Gene expression databases

    ArrayExpressiO60245.
    BgeeiO60245.
    CleanExiHS_PCDH7.
    GenevestigatoriO60245.

    Organism-specific databases

    HPAiHPA011866.

    Interactioni

    Protein-protein interaction databases

    BioGridi111132. 5 interactions.
    STRINGi9606.ENSP00000330302.

    Structurei

    Secondary structure

    1
    1069
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi309 – 31810
    Beta strandi326 – 3294
    Beta strandi335 – 3384
    Helixi354 – 3574
    Beta strandi358 – 3603
    Turni362 – 3643
    Beta strandi366 – 3694
    Turni375 – 3773
    Beta strandi379 – 3879
    Turni391 – 3944
    Beta strandi397 – 40610

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2YSTNMR-A302-413[»]
    ProteinModelPortaliO60245.
    SMRiO60245. Positions 259-860.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO60245.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini29 – 879851ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini901 – 1069169CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei880 – 90021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini29 – 143115Cadherin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini144 – 308165Cadherin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini309 – 415107Cadherin 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini424 – 535112Cadherin 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini536 – 639104Cadherin 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini640 – 742103Cadherin 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini745 – 862118Cadherin 7PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 7 cadherin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG148296.
    HOGENOMiHOG000234535.
    HOVERGENiHBG053523.
    KOiK16498.
    OrthoDBiEOG7WMCHN.
    PhylomeDBiO60245.

    Family and domain databases

    Gene3Di2.60.40.60. 8 hits.
    InterProiIPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR013164. Cadherin_N.
    IPR013585. Protocadherin.
    [Graphical view]
    PfamiPF00028. Cadherin. 6 hits.
    PF08266. Cadherin_2. 1 hit.
    PF08374. Protocadherin. 1 hit.
    [Graphical view]
    PRINTSiPR00205. CADHERIN.
    SMARTiSM00112. CA. 7 hits.
    [Graphical view]
    SUPFAMiSSF49313. SSF49313. 8 hits.
    PROSITEiPS00232. CADHERIN_1. 6 hits.
    PS50268. CADHERIN_2. 7 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform A (identifier: O60245-1) [UniParc]FASTAAdd to Basket

    Also known as: BH-Pcdh-a

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLRMRTAGWA RGWCLGCCLL LPLSLSLAAA KQLLRYRLAE EGPADVRIGN     50
    VASDLGIVTG SGEVTFSLES GSEYLKIDNL TGELSTSERR IDREKLPQCQ 100
    MIFDENECFL DFEVSVIGPS QSWVDLFEGQ VIVLDINDNT PTFPSPVLTL 150
    TVEENRPVGT LYLLPTATDR DFGRNGIERY ELLQEPGGGG SGGESRRAGA 200
    ADSAPYPGGG GNGASGGGSG GSKRRLDASE GGGGTNPGGR SSVFELQVAD 250
    TPDGEKQPQL IVKGALDREQ RDSYELTLRV RDGGDPPRSS QAILRVLITD 300
    VNDNSPRFEK SVYEADLAEN SAPGTPILQL RAADLDVGVN GQIEYVFGAA 350
    TESVRRLLRL DETSGWLSVL HRIDREEVNQ LRFTVMARDR GQPPKTDKAT 400
    VVLNIKDEND NVPSIEIRKI GRIPLKDGVA NVAEDVLVDT PIALVQVSDR 450
    DQGENGVVTC TVVGDVPFQL KPASDTEGDQ NKKKYFLHTS TPLDYEATRE 500
    FNVVIVAVDS GSPSLSSNNS LIVKVGDTND NPPMFGQSVV EVYFPENNIP 550
    GERVATVLAT DADSGKNAEI AYSLDSSVMG IFAIDPDSGD ILVNTVLDRE 600
    QTDRYEFKVN AKDKGIPVLQ GSTTVIVQVA DKNDNDPKFM QDVFTFYVKE 650
    NLQPNSPVGM VTVMDADKGR NAEMSLYIEE NNNIFSIEND TGTIYSTMSF 700
    DREHQTTYTF RVKAVDGGDP PRSATATVSL FVMDENDNAP TVTLPKNISY 750
    TLLPPSSNVR TVVATVLATD SDDGINADLN YSIVGGNPFK LFEIDPTSGV 800
    VSLVGKLTQK HYGLHRLVVQ VNDSGQPSQS TTTLVHVFVN ESVSNATAID 850
    SQIARSLHIP LTQDIAGDPS YEISKQRLSI VIGVVAGIMT VILIILIVVM 900
    ARYCRSKNKN GYEAGKKDHE DFFTPQQHDK SKKPKKDKKN KKSKQPLYSS 950
    IVTVEASKPN GQRYDSVNEK LSDSPSMGRY RSVNGGPGSP DLARHYKSSS 1000
    PLPTVQLHPQ SPTAGKKHQA VQDLPPANTF VGAGDNISIG SDHCSEYSCQ 1050
    TNNKYSKQMR LHPYITVFG 1069
    Length:1,069
    Mass (Da):116,071
    Last modified:July 28, 2009 - v2
    Checksum:i6150CAF0599D5DAF
    GO
    Isoform B (identifier: O60245-2) [UniParc]FASTAAdd to Basket

    Also known as: BH-Pcdh-b

    The sequence of this isoform differs from the canonical sequence as follows:
         1059-1069: MRLHPYITVFG → VRCIPNIFKYPREG

    Show »
    Length:1,072
    Mass (Da):116,429
    Checksum:iB37D12C7A156AF39
    GO

    Sequence cautioni

    The sequence BAA25196.1 differs from that shown. Reason: Aberrant splicing.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti25 – 251L → F in BAA25194. (PubMed:9615233)Curated
    Sequence conflicti25 – 251L → F in BAA25195. (PubMed:9615233)Curated
    Sequence conflicti25 – 251L → F in BAA25196. (PubMed:9615233)Curated
    Sequence conflicti518 – 5181N → K in BAA25194. (PubMed:9615233)Curated
    Sequence conflicti518 – 5181N → K in BAA25195. (PubMed:9615233)Curated
    Sequence conflicti518 – 5181N → K in BAA25196. (PubMed:9615233)Curated
    Sequence conflicti834 – 8341L → V in BAA25194. (PubMed:9615233)Curated
    Sequence conflicti834 – 8341L → V in BAA25195. (PubMed:9615233)Curated
    Sequence conflicti834 – 8341L → V in BAA25196. (PubMed:9615233)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1059 – 106911MRLHPYITVFG → VRCIPNIFKYPREG in isoform B. 1 PublicationVSP_000704Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB006755 mRNA. Translation: BAA25194.1.
    AB006756 mRNA. Translation: BAA25195.1.
    AB006757 mRNA. Translation: BAA25196.1. Sequence problems.
    AC097716 Genomic DNA. No translation available.
    AC098595 Genomic DNA. No translation available.
    AC107394 Genomic DNA. No translation available.
    AC110766 Genomic DNA. Translation: AAY40944.1.
    AC112239 Genomic DNA. No translation available.
    CCDSiCCDS33971.1. [O60245-1]
    PIRiT00041.
    T00042.
    RefSeqiNP_002580.2. NM_002589.2. [O60245-1]
    NP_115832.1. NM_032456.2. [O60245-2]
    UniGeneiHs.479439.

    Genome annotation databases

    EnsembliENST00000361762; ENSP00000355243; ENSG00000169851. [O60245-1]
    GeneIDi5099.
    KEGGihsa:5099.
    UCSCiuc003gsk.1. human. [O60245-1]
    uc021xnc.1. human. [O60245-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB006755 mRNA. Translation: BAA25194.1 .
    AB006756 mRNA. Translation: BAA25195.1 .
    AB006757 mRNA. Translation: BAA25196.1 . Sequence problems.
    AC097716 Genomic DNA. No translation available.
    AC098595 Genomic DNA. No translation available.
    AC107394 Genomic DNA. No translation available.
    AC110766 Genomic DNA. Translation: AAY40944.1 .
    AC112239 Genomic DNA. No translation available.
    CCDSi CCDS33971.1. [O60245-1 ]
    PIRi T00041.
    T00042.
    RefSeqi NP_002580.2. NM_002589.2. [O60245-1 ]
    NP_115832.1. NM_032456.2. [O60245-2 ]
    UniGenei Hs.479439.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2YST NMR - A 302-413 [» ]
    ProteinModelPortali O60245.
    SMRi O60245. Positions 259-860.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111132. 5 interactions.
    STRINGi 9606.ENSP00000330302.

    PTM databases

    PhosphoSitei O60245.

    Proteomic databases

    MaxQBi O60245.
    PaxDbi O60245.
    PRIDEi O60245.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000361762 ; ENSP00000355243 ; ENSG00000169851 . [O60245-1 ]
    GeneIDi 5099.
    KEGGi hsa:5099.
    UCSCi uc003gsk.1. human. [O60245-1 ]
    uc021xnc.1. human. [O60245-2 ]

    Organism-specific databases

    CTDi 5099.
    GeneCardsi GC04P030722.
    H-InvDB HIX0024543.
    HGNCi HGNC:8659. PCDH7.
    HPAi HPA011866.
    MIMi 602988. gene.
    neXtProti NX_O60245.
    PharmGKBi PA33006.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG148296.
    HOGENOMi HOG000234535.
    HOVERGENi HBG053523.
    KOi K16498.
    OrthoDBi EOG7WMCHN.
    PhylomeDBi O60245.

    Miscellaneous databases

    ChiTaRSi PCDH7. human.
    EvolutionaryTracei O60245.
    GeneWikii PCDH7.
    GenomeRNAii 5099.
    NextBioi 19678.
    PROi O60245.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O60245.
    Bgeei O60245.
    CleanExi HS_PCDH7.
    Genevestigatori O60245.

    Family and domain databases

    Gene3Di 2.60.40.60. 8 hits.
    InterProi IPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR013164. Cadherin_N.
    IPR013585. Protocadherin.
    [Graphical view ]
    Pfami PF00028. Cadherin. 6 hits.
    PF08266. Cadherin_2. 1 hit.
    PF08374. Protocadherin. 1 hit.
    [Graphical view ]
    PRINTSi PR00205. CADHERIN.
    SMARTi SM00112. CA. 7 hits.
    [Graphical view ]
    SUPFAMi SSF49313. SSF49313. 8 hits.
    PROSITEi PS00232. CADHERIN_1. 6 hits.
    PS50268. CADHERIN_2. 7 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, expression analysis, and chromosomal localization of BH-protocadherin (PCDH7), a novel member of the cadherin superfamily."
      Yoshida K., Yoshitomo-Nakagawa K., Seki N., Sasaki M., Sugano S.
      Genomics 49:458-461(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B).
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-989 AND SER-1011, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    4. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-989, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. "Solution structure of the third cadherin domain from human protocadherin 7."
      RIKEN structural genomics initiative (RSGI)
      Submitted (OCT-2007) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 302-413.

    Entry informationi

    Entry nameiPCDH7_HUMAN
    AccessioniPrimary (citable) accession number: O60245
    Secondary accession number(s): O60246, O60247, Q4W5C4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 5, 2001
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 130 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3