O60245 (PCDH7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protocadherin-7

Alternative name(s):
Brain-heart protocadherin
Short name=BH-Pcdh

Gene names

Name:	PCDH7
Synonyms:	BHPCDH

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1069 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Cell membrane; Single-pass type I membrane protein.
Tissue specificity	Expressed predominantly in brain and heart and at lower levels in various other tissues.
Post-translational modification	Isoform C is phosphorylated upon DNA damage, probably by ATM or ATR.
Sequence similarities	Contains 7 cadherin domains.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing
Domain	Repeat Signal Transmembrane Transmembrane helix
Ligand	Calcium
PTM	Glycoprotein Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	homophilic cell adhesion Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform A (identifier: O60245-1)

Also known as: BH-Pcdh-a;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform B (identifier: O60245-2)

Also known as: BH-Pcdh-b;

The sequence of this isoform differs from the canonical sequence as follows:
     1059-1069: MRLHPYITVFG → VRCIPNIFKYPREG

Isoform C (identifier: O60245-3)

Also known as: BH-Pcdh-c;

The sequence of this isoform differs from the canonical sequence as follows:
     265-311: Missing.
     1059-1069: MRLHPYITVFG → PFRRVTFSVV...NTLTRREVYL

Note: Dubious isoform produced through aberrant splice sites.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 28

28

Potential

Chain

29 – 1069

1041

Protocadherin-7

PRO_0000003992

Regions

Topological domain

29 – 879

851

Extracellular Potential

Transmembrane

880 – 900

21

Helical; Potential

Topological domain

901 – 1069

169

Cytoplasmic Potential

Domain

29 – 143

115

Cadherin 1

Domain

144 – 308

165

Cadherin 2

Domain

309 – 415

107

Cadherin 3

Domain

424 – 535

112

Cadherin 4

Domain

536 – 639

104

Cadherin 5

Domain

640 – 742

103

Cadherin 6

Domain

745 – 862

118

Cadherin 7

Amino acid modifications

Modified residue

989

1

Phosphoserine Ref.3 Ref.4

Modified residue

1011

1

Phosphoserine Ref.3

Glycosylation

79

1

N-linked (GlcNAc...) Potential

Glycosylation

689

1

N-linked (GlcNAc...) Potential

Glycosylation

747

1

N-linked (GlcNAc...) Potential

Glycosylation

780

1

N-linked (GlcNAc...) Potential

Glycosylation

822

1

N-linked (GlcNAc...) Potential

Glycosylation

840

1

N-linked (GlcNAc...) Potential

Glycosylation

845

1

N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence

265 – 311

47

Missing in isoform C.

VSP_000705

Alternative sequence

1059 – 1069

11

MRLHPYITVFG → VRCIPNIFKYPREG in isoform B.

VSP_000704

Alternative sequence

1059 – 1069

11

MRLHPYITVFG → PFRRVTFSVVSQPQDPHQGS LQSCYDSGLEESETPSSKSS SGPRLGALPLPEDNYERTTP DGSVDSRPLPDVALTGKCTR ECDEYGHSDSCWMPVRTSPE RKKSQPKLSTFMPVDERGSQ EKLANGEAAIMGDRNRNLLN KKLTSSYETFSAASFSKNEE ANPEDIPLTKTGEYKPSPVN TLTRREVYL in isoform C.

VSP_000706

Experimental info

Sequence conflict

25

1

L → F in BAA25194. Ref.1

Sequence conflict

25

1

L → F in BAA25195. Ref.1

Sequence conflict

25

1

L → F in BAA25196. Ref.1

Sequence conflict

518

1

N → K in BAA25194. Ref.1

Sequence conflict

518

1

N → K in BAA25195. Ref.1

Sequence conflict

518

1

N → K in BAA25196. Ref.1

Sequence conflict

834

1

L → V in BAA25194. Ref.1

Sequence conflict

834

1

L → V in BAA25195. Ref.1

Sequence conflict

834

1

L → V in BAA25196. Ref.1

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

1069

Helix Strand Turn

Details...

Beta strand

309 – 318

10

Beta strand

326 – 329

4

Beta strand

335 – 338

4

Helix

354 – 357

4

Beta strand

358 – 360

3

Turn

362 – 364

3

Beta strand

366 – 369

4

Turn

375 – 377

3

Beta strand

379 – 387

9

Turn

391 – 394

4

Beta strand

397 – 406

10

Sequences

	Sequence		Length	Mass (Da)
	Isoform A (BH-Pcdh-a) [UniParc]. Last modified July 28, 2009. Version 2. Checksum: 6150CAF0599D5DAF	FASTA	1,069	116,071
	10 20 30 40 50 60 MLRMRTAGWA RGWCLGCCLL LPLSLSLAAA KQLLRYRLAE EGPADVRIGN VASDLGIVTG 70 80 90 100 110 120 SGEVTFSLES GSEYLKIDNL TGELSTSERR IDREKLPQCQ MIFDENECFL DFEVSVIGPS 130 140 150 160 170 180 QSWVDLFEGQ VIVLDINDNT PTFPSPVLTL TVEENRPVGT LYLLPTATDR DFGRNGIERY 190 200 210 220 230 240 ELLQEPGGGG SGGESRRAGA ADSAPYPGGG GNGASGGGSG GSKRRLDASE GGGGTNPGGR 250 260 270 280 290 300 SSVFELQVAD TPDGEKQPQL IVKGALDREQ RDSYELTLRV RDGGDPPRSS QAILRVLITD 310 320 330 340 350 360 VNDNSPRFEK SVYEADLAEN SAPGTPILQL RAADLDVGVN GQIEYVFGAA TESVRRLLRL 370 380 390 400 410 420 DETSGWLSVL HRIDREEVNQ LRFTVMARDR GQPPKTDKAT VVLNIKDEND NVPSIEIRKI 430 440 450 460 470 480 GRIPLKDGVA NVAEDVLVDT PIALVQVSDR DQGENGVVTC TVVGDVPFQL KPASDTEGDQ 490 500 510 520 530 540 NKKKYFLHTS TPLDYEATRE FNVVIVAVDS GSPSLSSNNS LIVKVGDTND NPPMFGQSVV 550 560 570 580 590 600 EVYFPENNIP GERVATVLAT DADSGKNAEI AYSLDSSVMG IFAIDPDSGD ILVNTVLDRE 610 620 630 640 650 660 QTDRYEFKVN AKDKGIPVLQ GSTTVIVQVA DKNDNDPKFM QDVFTFYVKE NLQPNSPVGM 670 680 690 700 710 720 VTVMDADKGR NAEMSLYIEE NNNIFSIEND TGTIYSTMSF DREHQTTYTF RVKAVDGGDP 730 740 750 760 770 780 PRSATATVSL FVMDENDNAP TVTLPKNISY TLLPPSSNVR TVVATVLATD SDDGINADLN 790 800 810 820 830 840 YSIVGGNPFK LFEIDPTSGV VSLVGKLTQK HYGLHRLVVQ VNDSGQPSQS TTTLVHVFVN 850 860 870 880 890 900 ESVSNATAID SQIARSLHIP LTQDIAGDPS YEISKQRLSI VIGVVAGIMT VILIILIVVM 910 920 930 940 950 960 ARYCRSKNKN GYEAGKKDHE DFFTPQQHDK SKKPKKDKKN KKSKQPLYSS IVTVEASKPN 970 980 990 1000 1010 1020 GQRYDSVNEK LSDSPSMGRY RSVNGGPGSP DLARHYKSSS PLPTVQLHPQ SPTAGKKHQA 1030 1040 1050 1060 VQDLPPANTF VGAGDNISIG SDHCSEYSCQ TNNKYSKQMR LHPYITVFG
	Isoform B (BH-Pcdh-b) [UniParc]. Checksum: B37D12C7A156AF39	FASTA	1,072	116,429
	10 20 30 40 50 60 MLRMRTAGWA RGWCLGCCLL LPLSLSLAAA KQLLRYRLAE EGPADVRIGN VASDLGIVTG 70 80 90 100 110 120 SGEVTFSLES GSEYLKIDNL TGELSTSERR IDREKLPQCQ MIFDENECFL DFEVSVIGPS 130 140 150 160 170 180 QSWVDLFEGQ VIVLDINDNT PTFPSPVLTL TVEENRPVGT LYLLPTATDR DFGRNGIERY 190 200 210 220 230 240 ELLQEPGGGG SGGESRRAGA ADSAPYPGGG GNGASGGGSG GSKRRLDASE GGGGTNPGGR 250 260 270 280 290 300 SSVFELQVAD TPDGEKQPQL IVKGALDREQ RDSYELTLRV RDGGDPPRSS QAILRVLITD 310 320 330 340 350 360 VNDNSPRFEK SVYEADLAEN SAPGTPILQL RAADLDVGVN GQIEYVFGAA TESVRRLLRL 370 380 390 400 410 420 DETSGWLSVL HRIDREEVNQ LRFTVMARDR GQPPKTDKAT VVLNIKDEND NVPSIEIRKI 430 440 450 460 470 480 GRIPLKDGVA NVAEDVLVDT PIALVQVSDR DQGENGVVTC TVVGDVPFQL KPASDTEGDQ 490 500 510 520 530 540 NKKKYFLHTS TPLDYEATRE FNVVIVAVDS GSPSLSSNNS LIVKVGDTND NPPMFGQSVV 550 560 570 580 590 600 EVYFPENNIP GERVATVLAT DADSGKNAEI AYSLDSSVMG IFAIDPDSGD ILVNTVLDRE 610 620 630 640 650 660 QTDRYEFKVN AKDKGIPVLQ GSTTVIVQVA DKNDNDPKFM QDVFTFYVKE NLQPNSPVGM 670 680 690 700 710 720 VTVMDADKGR NAEMSLYIEE NNNIFSIEND TGTIYSTMSF DREHQTTYTF RVKAVDGGDP 730 740 750 760 770 780 PRSATATVSL FVMDENDNAP TVTLPKNISY TLLPPSSNVR TVVATVLATD SDDGINADLN 790 800 810 820 830 840 YSIVGGNPFK LFEIDPTSGV VSLVGKLTQK HYGLHRLVVQ VNDSGQPSQS TTTLVHVFVN 850 860 870 880 890 900 ESVSNATAID SQIARSLHIP LTQDIAGDPS YEISKQRLSI VIGVVAGIMT VILIILIVVM 910 920 930 940 950 960 ARYCRSKNKN GYEAGKKDHE DFFTPQQHDK SKKPKKDKKN KKSKQPLYSS IVTVEASKPN 970 980 990 1000 1010 1020 GQRYDSVNEK LSDSPSMGRY RSVNGGPGSP DLARHYKSSS PLPTVQLHPQ SPTAGKKHQA 1030 1040 1050 1060 1070 VQDLPPANTF VGAGDNISIG SDHCSEYSCQ TNNKYSKQVR CIPNIFKYPR EG
	Isoform C (BH-Pcdh-c) [UniParc]. Checksum: EEBCEDC65B42F2E0	FASTA	1,200	130,304
	10 20 30 40 50 60 MLRMRTAGWA RGWCLGCCLL LPLSLSLAAA KQLLRYRLAE EGPADVRIGN VASDLGIVTG 70 80 90 100 110 120 SGEVTFSLES GSEYLKIDNL TGELSTSERR IDREKLPQCQ MIFDENECFL DFEVSVIGPS 130 140 150 160 170 180 QSWVDLFEGQ VIVLDINDNT PTFPSPVLTL TVEENRPVGT LYLLPTATDR DFGRNGIERY 190 200 210 220 230 240 ELLQEPGGGG SGGESRRAGA ADSAPYPGGG GNGASGGGSG GSKRRLDASE GGGGTNPGGR 250 260 270 280 290 300 SSVFELQVAD TPDGEKQPQL IVKGVYEADL AENSAPGTPI LQLRAADLDV GVNGQIEYVF 310 320 330 340 350 360 GAATESVRRL LRLDETSGWL SVLHRIDREE VNQLRFTVMA RDRGQPPKTD KATVVLNIKD 370 380 390 400 410 420 ENDNVPSIEI RKIGRIPLKD GVANVAEDVL VDTPIALVQV SDRDQGENGV VTCTVVGDVP 430 440 450 460 470 480 FQLKPASDTE GDQNKKKYFL HTSTPLDYEA TREFNVVIVA VDSGSPSLSS NNSLIVKVGD 490 500 510 520 530 540 TNDNPPMFGQ SVVEVYFPEN NIPGERVATV LATDADSGKN AEIAYSLDSS VMGIFAIDPD 550 560 570 580 590 600 SGDILVNTVL DREQTDRYEF KVNAKDKGIP VLQGSTTVIV QVADKNDNDP KFMQDVFTFY 610 620 630 640 650 660 VKENLQPNSP VGMVTVMDAD KGRNAEMSLY IEENNNIFSI ENDTGTIYST MSFDREHQTT 670 680 690 700 710 720 YTFRVKAVDG GDPPRSATAT VSLFVMDEND NAPTVTLPKN ISYTLLPPSS NVRTVVATVL 730 740 750 760 770 780 ATDSDDGINA DLNYSIVGGN PFKLFEIDPT SGVVSLVGKL TQKHYGLHRL VVQVNDSGQP 790 800 810 820 830 840 SQSTTTLVHV FVNESVSNAT AIDSQIARSL HIPLTQDIAG DPSYEISKQR LSIVIGVVAG 850 860 870 880 890 900 IMTVILIILI VVMARYCRSK NKNGYEAGKK DHEDFFTPQQ HDKSKKPKKD KKNKKSKQPL 910 920 930 940 950 960 YSSIVTVEAS KPNGQRYDSV NEKLSDSPSM GRYRSVNGGP GSPDLARHYK SSSPLPTVQL 970 980 990 1000 1010 1020 HPQSPTAGKK HQAVQDLPPA NTFVGAGDNI SIGSDHCSEY SCQTNNKYSK QPFRRVTFSV 1030 1040 1050 1060 1070 1080 VSQPQDPHQG SLQSCYDSGL EESETPSSKS SSGPRLGALP LPEDNYERTT PDGSVDSRPL 1090 1100 1110 1120 1130 1140 PDVALTGKCT RECDEYGHSD SCWMPVRTSP ERKKSQPKLS TFMPVDERGS QEKLANGEAA 1150 1160 1170 1180 1190 1200 IMGDRNRNLL NKKLTSSYET FSAASFSKNE EANPEDIPLT KTGEYKPSPV NTLTRREVYL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, expression analysis, and chromosomal localization of BH-protocadherin (PCDH7), a novel member of the cadherin superfamily." Yoshida K., Yoshitomo-Nakagawa K., Seki N., Sasaki M., Sugano S. Genomics 49:458-461(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B AND C).
[2]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-989 AND SER-1011, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[4]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-989, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[5]	"Solution structure of the third cadherin domain from human protocadherin 7." RIKEN structural genomics initiative (RSGI) Submitted (OCT-2007) to the PDB data bank Cited for: STRUCTURE BY NMR OF 302-413.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB006755 mRNA. Translation: BAA25194.1.
AB006756 mRNA. Translation: BAA25195.1.
AB006757 mRNA. Translation: BAA25196.1.
AC097716 Genomic DNA. No translation available.
AC098595 Genomic DNA. No translation available.
AC107394 Genomic DNA. No translation available.
AC110766 Genomic DNA. Translation: AAY40944.1.
AC112239 Genomic DNA. No translation available.

IPI

IPI00001893.
IPI00215946.
IPI00289870.

PIR

T00041.
T00042.

RefSeq

NP_002580.2. NM_002589.2.
NP_115832.1. NM_032456.2.

UniGene

Hs.479439.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2YST	NMR	-	A	302-413	[»]

ProteinModelPortal

O60245.

ModBase

Search...

Protein-protein interaction databases

STRING

9606.ENSP00000330302.

PTM databases

PhosphoSite

O60245.

Proteomic databases

PaxDb

O60245.

PRIDE

O60245.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000361762; ENSP00000355243; ENSG00000169851.

GeneID

5099.

KEGG

hsa:5099.

UCSC

uc003gsk.1. human.
uc021xnc.1. human.

Organism-specific databases

CTD

5099.

GeneCards

GC04P030722.

H-InvDB

HIX0024543.

HGNC

HGNC:8659. PCDH7.

HPA

HPA011866.

MIM

602988. gene.

neXtProt

NX_O60245.

PharmGKB

PA33006.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG148296.

HOGENOM

HOG000234535.

HOVERGEN

HBG053523.

KO

K16498.

OrthoDB

EOG42820V.

Gene expression databases

ArrayExpress

O60245.

Bgee

O60245.

CleanEx

HS_PCDH7.

Genevestigator

O60245.

GermOnline

ENSG00000169851. Homo sapiens.

Family and domain databases

Gene3D

2.60.40.60. 8 hits.

InterPro

IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
IPR013585. Protocadherin.
[Graphical view]

Pfam

PF00028. Cadherin. 6 hits.
PF08266. Cadherin_2. 1 hit.
PF08374. Protocadherin. 1 hit.
[Graphical view]

PRINTS

PR00205. CADHERIN.

SMART

SM00112. CA. 7 hits.
[Graphical view]

SUPFAM

SSF49313. Cadherin. 6 hits.

PROSITE

PS00232. CADHERIN_1. 6 hits.
PS50268. CADHERIN_2. 7 hits.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

PCDH7. human.

EvolutionaryTrace

O60245.

GenomeRNAi

5099.

NextBio

19678.

SOURCE

Search...

Entry information

Entry name

PCDH7_HUMAN

Accession

Primary (citable) accession number: O60245
Secondary accession number(s): O60246, O60247, Q4W5C4

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 5, 2001
Last sequence update:	July 28, 2009
Last modified:	May 1, 2013
This is version 117 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.