Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O60245 (PCDH7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 126. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protocadherin-7
Alternative name(s):
Brain-heart protocadherin
Short name=BH-Pcdh
Gene names
Name:PCDH7
Synonyms:BHPCDH
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1069 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Cell membrane; Single-pass type I membrane protein.

Tissue specificity

Expressed predominantly in brain and heart and at lower levels in various other tissues.

Sequence similarities

Contains 7 cadherin domains.

Sequence caution

The sequence BAA25196.1 differs from that shown. Reason: Aberrant splicing.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentCell membrane
Membrane
   Coding sequence diversityAlternative splicing
   DomainRepeat
Signal
Transmembrane
Transmembrane helix
   LigandCalcium
   PTMGlycoprotein
Phosphoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processhomophilic cell adhesion

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral component of plasma membrane

Traceable author statement Ref.1. Source: ProtInc

plasma membrane

Traceable author statement Ref.1. Source: ProtInc

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform A (identifier: O60245-1)

Also known as: BH-Pcdh-a;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform B (identifier: O60245-2)

Also known as: BH-Pcdh-b;

The sequence of this isoform differs from the canonical sequence as follows:
     1059-1069: MRLHPYITVFG → VRCIPNIFKYPREG

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828 Potential
Chain29 – 10691041Protocadherin-7
PRO_0000003992

Regions

Topological domain29 – 879851Extracellular Potential
Transmembrane880 – 90021Helical; Potential
Topological domain901 – 1069169Cytoplasmic Potential
Domain29 – 143115Cadherin 1
Domain144 – 308165Cadherin 2
Domain309 – 415107Cadherin 3
Domain424 – 535112Cadherin 4
Domain536 – 639104Cadherin 5
Domain640 – 742103Cadherin 6
Domain745 – 862118Cadherin 7

Amino acid modifications

Modified residue9891Phosphoserine Ref.3 Ref.5
Modified residue10111Phosphoserine Ref.3
Glycosylation791N-linked (GlcNAc...) Potential
Glycosylation6891N-linked (GlcNAc...) Potential
Glycosylation7471N-linked (GlcNAc...) Potential
Glycosylation7801N-linked (GlcNAc...) Potential
Glycosylation8221N-linked (GlcNAc...) Potential
Glycosylation8401N-linked (GlcNAc...) Potential
Glycosylation8451N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence1059 – 106911MRLHPYITVFG → VRCIPNIFKYPREG in isoform B.
VSP_000704

Experimental info

Sequence conflict251L → F in BAA25194. Ref.1
Sequence conflict251L → F in BAA25195. Ref.1
Sequence conflict251L → F in BAA25196. Ref.1
Sequence conflict5181N → K in BAA25194. Ref.1
Sequence conflict5181N → K in BAA25195. Ref.1
Sequence conflict5181N → K in BAA25196. Ref.1
Sequence conflict8341L → V in BAA25194. Ref.1
Sequence conflict8341L → V in BAA25195. Ref.1
Sequence conflict8341L → V in BAA25196. Ref.1

Secondary structure

...................... 1069
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform A (BH-Pcdh-a) [UniParc].

Last modified July 28, 2009. Version 2.
Checksum: 6150CAF0599D5DAF

FASTA1,069116,071
        10         20         30         40         50         60 
MLRMRTAGWA RGWCLGCCLL LPLSLSLAAA KQLLRYRLAE EGPADVRIGN VASDLGIVTG 

        70         80         90        100        110        120 
SGEVTFSLES GSEYLKIDNL TGELSTSERR IDREKLPQCQ MIFDENECFL DFEVSVIGPS 

       130        140        150        160        170        180 
QSWVDLFEGQ VIVLDINDNT PTFPSPVLTL TVEENRPVGT LYLLPTATDR DFGRNGIERY 

       190        200        210        220        230        240 
ELLQEPGGGG SGGESRRAGA ADSAPYPGGG GNGASGGGSG GSKRRLDASE GGGGTNPGGR 

       250        260        270        280        290        300 
SSVFELQVAD TPDGEKQPQL IVKGALDREQ RDSYELTLRV RDGGDPPRSS QAILRVLITD 

       310        320        330        340        350        360 
VNDNSPRFEK SVYEADLAEN SAPGTPILQL RAADLDVGVN GQIEYVFGAA TESVRRLLRL 

       370        380        390        400        410        420 
DETSGWLSVL HRIDREEVNQ LRFTVMARDR GQPPKTDKAT VVLNIKDEND NVPSIEIRKI 

       430        440        450        460        470        480 
GRIPLKDGVA NVAEDVLVDT PIALVQVSDR DQGENGVVTC TVVGDVPFQL KPASDTEGDQ 

       490        500        510        520        530        540 
NKKKYFLHTS TPLDYEATRE FNVVIVAVDS GSPSLSSNNS LIVKVGDTND NPPMFGQSVV 

       550        560        570        580        590        600 
EVYFPENNIP GERVATVLAT DADSGKNAEI AYSLDSSVMG IFAIDPDSGD ILVNTVLDRE 

       610        620        630        640        650        660 
QTDRYEFKVN AKDKGIPVLQ GSTTVIVQVA DKNDNDPKFM QDVFTFYVKE NLQPNSPVGM 

       670        680        690        700        710        720 
VTVMDADKGR NAEMSLYIEE NNNIFSIEND TGTIYSTMSF DREHQTTYTF RVKAVDGGDP 

       730        740        750        760        770        780 
PRSATATVSL FVMDENDNAP TVTLPKNISY TLLPPSSNVR TVVATVLATD SDDGINADLN 

       790        800        810        820        830        840 
YSIVGGNPFK LFEIDPTSGV VSLVGKLTQK HYGLHRLVVQ VNDSGQPSQS TTTLVHVFVN 

       850        860        870        880        890        900 
ESVSNATAID SQIARSLHIP LTQDIAGDPS YEISKQRLSI VIGVVAGIMT VILIILIVVM 

       910        920        930        940        950        960 
ARYCRSKNKN GYEAGKKDHE DFFTPQQHDK SKKPKKDKKN KKSKQPLYSS IVTVEASKPN 

       970        980        990       1000       1010       1020 
GQRYDSVNEK LSDSPSMGRY RSVNGGPGSP DLARHYKSSS PLPTVQLHPQ SPTAGKKHQA 

      1030       1040       1050       1060 
VQDLPPANTF VGAGDNISIG SDHCSEYSCQ TNNKYSKQMR LHPYITVFG 

« Hide

Isoform B (BH-Pcdh-b) [UniParc].

Checksum: B37D12C7A156AF39
Show »

FASTA1,072116,429

References

« Hide 'large scale' references
[1]"Cloning, expression analysis, and chromosomal localization of BH-protocadherin (PCDH7), a novel member of the cadherin superfamily."
Yoshida K., Yoshitomo-Nakagawa K., Seki N., Sasaki M., Sugano S.
Genomics 49:458-461(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B).
[2]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-989 AND SER-1011, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[4]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[5]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-989, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[6]"Solution structure of the third cadherin domain from human protocadherin 7."
RIKEN structural genomics initiative (RSGI)
Submitted (OCT-2007) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 302-413.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB006755 mRNA. Translation: BAA25194.1.
AB006756 mRNA. Translation: BAA25195.1.
AB006757 mRNA. Translation: BAA25196.1. Sequence problems.
AC097716 Genomic DNA. No translation available.
AC098595 Genomic DNA. No translation available.
AC107394 Genomic DNA. No translation available.
AC110766 Genomic DNA. Translation: AAY40944.1.
AC112239 Genomic DNA. No translation available.
PIRT00041.
T00042.
RefSeqNP_002580.2. NM_002589.2.
NP_115832.1. NM_032456.2.
UniGeneHs.479439.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2YSTNMR-A302-413[»]
ProteinModelPortalO60245.
SMRO60245. Positions 30-860.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid111132. 5 interactions.
STRING9606.ENSP00000330302.

PTM databases

PhosphoSiteO60245.

Proteomic databases

PaxDbO60245.
PRIDEO60245.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000361762; ENSP00000355243; ENSG00000169851. [O60245-1]
GeneID5099.
KEGGhsa:5099.
UCSCuc003gsk.1. human. [O60245-1]
uc021xnc.1. human. [O60245-2]

Organism-specific databases

CTD5099.
GeneCardsGC04P030722.
H-InvDBHIX0024543.
HGNCHGNC:8659. PCDH7.
HPAHPA011866.
MIM602988. gene.
neXtProtNX_O60245.
PharmGKBPA33006.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG148296.
HOGENOMHOG000234535.
HOVERGENHBG053523.
KOK16498.
OrthoDBEOG7WMCHN.
PhylomeDBO60245.

Gene expression databases

ArrayExpressO60245.
BgeeO60245.
CleanExHS_PCDH7.
GenevestigatorO60245.

Family and domain databases

Gene3D2.60.40.60. 8 hits.
InterProIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
IPR013585. Protocadherin.
[Graphical view]
PfamPF00028. Cadherin. 6 hits.
PF08266. Cadherin_2. 1 hit.
PF08374. Protocadherin. 1 hit.
[Graphical view]
PRINTSPR00205. CADHERIN.
SMARTSM00112. CA. 7 hits.
[Graphical view]
SUPFAMSSF49313. SSF49313. 8 hits.
PROSITEPS00232. CADHERIN_1. 6 hits.
PS50268. CADHERIN_2. 7 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPCDH7. human.
EvolutionaryTraceO60245.
GeneWikiPCDH7.
GenomeRNAi5099.
NextBio19678.
PROO60245.
SOURCESearch...

Entry information

Entry namePCDH7_HUMAN
AccessionPrimary (citable) accession number: O60245
Secondary accession number(s): O60246, O60247, Q4W5C4
Entry history
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: July 28, 2009
Last modified: April 16, 2014
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM